SMDB

System biology database of Mollicutes: Mycoplasma gallisepticum, Spiroplasma melliferum and Acholeplasma laidlawii

We collected and compared different OMICS data of three bacteria species to understand biology and evolution genome reduces bacteria. Our bacteria belongs to the Mollicutes class — a specialized branch of microorganisms related to Gram-positive bacteria. Mollicutes feature reduced genomes with an average size of 1 Mb, and they lack a cell wall. Consequently, their cell physiology is considerably simplified compared to that of most bacteria, making Mollicutes a good model for systemic studies. These three bacteria have individual features that reflect their different lifestyles. M. gallisepticum is an important pathogen in poultry and wild birds, in which it causes chronic respiratory disease. A. laidlawii is characterized as commensal or saprophyte whereas S. melliferum lives attached to host cells or inside the host eukaryotic cells in plants and insects.

Database includes comprehensive information about genome organization, metabolic pathways, RNA expression and protein abundances data in different conditions. Based on this data we predicted and partially validated transcription regulation networks for our bacteria that also avaliable for downloading.