PMID- 22611248
OWN - NLM
STAT- MEDLINE
DA  - 20120521
DCOM- 20120814
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 188
IP  - 11
DP  - 2012 Jun 1
TI  - Pillars article: the dorsoventral regulatory gene cassette spatzle/Toll/cactus
      controls the potent antifungal response in Drosophila adults. Cell. 1996. 86:
      973-983.
PG  - 5210-20
AB  - The cytokine-induced activation cascade of NF-kappaB in mammals and the
      activation of the morphogen dorsal in Drosophila embryos show striking structural
      and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB).
      Here we demonstrate that these parallels extend to the immune response of
      Drosophila. In particular, the intracellular components of the dorsoventral
      signaling pathway (except for dorsal) and the extracellular Toll ligand, spatzle 
      regulatory gene cassette, control expression of the antifungal peptide gene
      drosomycin in adults. We also show that mutations in the Toll signaling pathway
      dramatically reduce survival after fungal infection. Antibacterial genes are
      induced either by a distinct pathway involving the immune deficiency gene (imd)
      or by combined activation of both imd and dorsoventral pathways.
FAU - Lemaitre, Bruno
AU  - Lemaitre B
FAU - Nicolas, Emmanuelle
AU  - Nicolas E
FAU - Michaut, Lydia
AU  - Michaut L
FAU - Reichhart, Jean-Marc
AU  - Reichhart JM
FAU - Hoffmann, Jules A
AU  - Hoffmann JA
LA  - eng
PT  - Biography
PT  - Classical Article
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antifungal Agents)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Tl protein, Drosophila)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (spatzle protein, Drosophila)
RN  - 149059-01-8 (cactus protein, Drosophila)
SB  - AIM
SB  - IM
CIN - J Immunol. 2012 Jun 1;188(11):5207-9. PMID: 22611247
MH  - Animals
MH  - Antifungal Agents/*metabolism
MH  - DNA-Binding Proteins/*physiology
MH  - Drosophila Proteins/*physiology
MH  - Drosophila melanogaster/growth & development/*immunology/metabolism
MH  - Gene Expression Regulation, Developmental/*immunology
MH  - History, 20th Century
MH  - Multigene Family/genetics
MH  - Mycoses/*immunology/metabolism/*prevention & control
MH  - Phosphoproteins/*physiology
MH  - Toll-Like Receptors/*physiology
EDAT- 2012/05/23 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/05/22 06:00
AID - 188/11/5210 [pii]
PST - ppublish
SO  - J Immunol. 2012 Jun 1;188(11):5210-20.