>tr|A0A127F4Z7|A0A127F4Z7_STEDE/6-740 CRISPR-associated endonuclease/helicase Cas3 OS=Steroidobacter denitrificans OX=465721 GN=ACG33_00095 PE=4 SV=1
PIAHATRD-AD--------GNW-----RPPHDLLEHLHEVGELAADFARRYG---ADWARLAGRWHDLGKFR
PRFQKYIRFVSGFEADAHIKGEAGK----APH---STAGALLACEHFEKAG---FGPAGRVLAYLIAGHHAG
LADW--FG------------GLRERLEDP-----KSRAELDE--SLVEQPPTELLDS---GDFKPDLRA---
-----------VPGGRDGF--ALWIRMLFSALVDADFLDTERYMDPD----RFASRNTW-----PTLEELAP
LFDAHMTKL-----------VAGADPTPVNALRADILRQCHDAA--A-LDA---GLFSLTVPTGGGKTLSGM
AFALEHARGHSKRRIIHVIPYTSIIEQTADVF-----------------RDIFGDA------VVEHHSNAES
EP-------------DKETSASRLACENWDAPIVVTTNVQFFESLFASRTSRCRKLHNIVDSVVILDEAQLL
PPEFLQPILDVLNLLTRHYGVTVVLSTATQPAL-----ASREYFDT----RQNRRGL----DNVREIIS---
-DPDALYVAL-ERVEVRL-P--SDWHQPTDWPQLTEAL--CAHESVLAIVNTRKDARALWEA----------
--MPQ-----GTLHLSALMCGAHRSQVIADIKARL--K-----AGAS---TSVVSTQLVEAGVDVDFPVVYR
ALAGLDSIAQAAGRCNREGR-LKGKGEVVVFVPPE--P-AP-QGL--LRQGENACREVLR--DAADSP----
---LARTRFAAYFERLY----YGC-----------QLD--------K-----------AGI-------RELL
SV--K----DSHELAVDFRTAAE---KFRLIDDEDSLPIVVRYSGKDGRDERIDQWLAMLRR----D---GP
QRWLMRKLQRYTVSLRRRQVLP-LLNRGDIEE------ILPGL----YAQTGDG---------LYDENLGL
>tr|K4LIA0|K4LIA0_THEPS/6-740 CRISPR-associated endonuclease Cas3-HD OS=Thermacetogenium phaeum (strain ATCC BAA-254 / DSM 12270 / PB) OX=1089553 GN=cas3# PE=4 SV=1
VYSHKGKR------------------------LEQHLLETAELAQKIARHFRLELEEGERWALLLHDLAKAH
PLFQKHLL------------QQKGR----FGH---AAPSAALVLGLTGD----------LLCTEAVRRHHSS
LEN---LDE---AKKFWFCWDYQENACGVI----GKIPVWNGAEAVMEALGHQLAKW--GELLPAQADWDEL
IFERVEFF---PPDEEKMEEAWLRLRMLYSLLVTADR------YNAAVG--REMEY--------HPLRIDQK
RVEDFAASL---------------RGRPLAEWRQQVREEVVRKAEEVLKKP---GIYTLTLPTGAGKTLVGL
ELAMLAAERFAATGIIYVLPFISLVEQNADVA-----------------RVLFKDASP----VREDHYLSEV
AG------EEGDPENSSPQERFLSFFRYWQEPVVITTMAKFWEVLYSPKGNDTMSLHRLSRAVVILDEPQAI
PSCYWQGFGKTLNLLSEKLNTTFILMTATQPEI----------------------------AQGLELAP---
--RPYFFPMIRHRFEWRRER--LTVPELLGSPDVISKL--LA-KSALLVFNTHRSALLAYLEL--------Q
SRGVT------SYFLSGWVTPLDRRATLQQIREDE--S-----AGKP---ARLVSTQVVEAGVDLDFQFVYR
DLGPLDSIIQVAGRCNRHGK--REQGEVLVCELCDENG-RSYAGYVYDSTLLVATKAVLK--DSFDER----
---DCPGMVAAYYRKVR----EITAENPLWE----DIS--------------------SGR-------WGEF
HDLIEKEERGEATLVVAYEGVEN---DLDLL-SRQAAP-----------DEDVMRMVEQ-------------
KREASRRLGLHAVSVPVKMLEEWLLRVGGMIYGAESGDILRKVSSGIYLVQGEG------IGRIYSRRTGF
>tr|C4V2W5|C4V2W5_9FIRM/6-802 CRISPR-associated endonuclease Cas3-HD OS=Selenomonas flueggei ATCC 43531 OX=638302 GN=HMPREF0908_0829 PE=4 SV=1
YLAHIRRD-GS-------KE-------QS---MEDHLLRVGNLMKEDAARLG--LSSLAYLIGVLHDLGKCT
AEFAEYLDWCRKHPGDYSRRGE-------VDH---ATAGGQLLLVQYGRKNAD-YRFVAEIASLVIFSHHTG
LLNY--YGQDGKDESS----DFLRRNDKADILSRVDLKYFFS-EVIAEEELNRIFEQSIYEIVDLDAKIACA
VHCSDD-----EMSEAYCFYWGMVHKLLLSMLIDADRLDSAEFELD-----RPLTDEWETA---EIWASFSD
KLECKLAGF---------SLPKEPKAKKIAQLRKKISDDCLKAA--E-EEP---GIFRLCVPTGGGKTLASM
RFALQHAQRYQKKRIIVVIPYTSIIDQNVKEI-----------------RDIFRVDEA----ILEHHSNVIT
EA---------DGEDTESMDWRRILTERWDVPIIFTTQVQFLNTLFAGGNSSIRRMNSLQDSIVIFDEIQTL
PVRCTFLFNAAMNFLKDFCRITAVLCTATQPPL------EKLDVS---------INL----SDNAAMTS---
-DIEKTFEGF-ERVDVENCYRDGGWSAEEIASEICKSV--EEIGDVLCIVNLTKKAKEIYQAV----SEKIQ
LSDKE----IQIVHLSTKMCSAHRKATLKELRRALAER-----KNHPEKRLVCISTQLIEAGVDVSFPVVYR
ALAGFSSIAQAAGRCNRHGE--MEKGIVRVFECADENL-DH-LKD--IRHGKNIARVMLY--DRAANT----
--ILSPSIMQEYFRRFY----AGRTGKEMRY----PLS-------TQNTIFDLLSGNSAGV---------QA
RM--GRGDRISSYFRQAFRDAGR---SFTVI-DSHSEAVLVPY-------AGGKDMIVAFDDRIFDR---KS
IGKQMKSAQQYMVNLFSYEIKE-LAGLGAV-----------WRTESGVMALREE---------YYNEAFGV
>tr|A0A2A4I6Y9|A0A2A4I6Y9_9SPHN/14-761 CRISPR-associated endonuclease Cas3 OS=Sphingomonas adhaesiva OX=28212 GN=COA07_10695 PE=4 SV=1
LYGHSLPG-QP-------ETTW-----EL---LAPHLVAVGDLAAQFAGRFG--ASEAARLAGYLHDIGKAS
REFQRYIK------------DDGKS----PDH---STAGAIVADGLFADGA---DRLIARLVALAIAGHHAG
LADG-------------R--DLGERLG-------REVPAYAG---WRT-LGLELPPS----ILPKLAG----
-----------GSGASNGYRLGFLGRMIFSCLVDADFIATERFYAAADG--RAVARGGH-----APLTELRE
RLDRYLATV------------IAGRSGALSATRAAILAHARAKA--P-LTP---GLFTMTVPTGGGKTLAGL
AFALDHAIAHGLDRVIVVAPYSAIIEQTAQVF-----------------RTALADDDGEAPDVLEHTGTVDW
DA---RERDSRDEGARDAQAKLRRSSENWDVPVVVTTAVQFFESLHADRPSRCRKLHNLAGSVIVLDEAQTL
PVSLLRPCMAAIDELAAGYRASVVLCTATQPAL-----TTDAGFP------RQHGGLEI--PPDRELAP---
-DPQGLYDKL-KRVTVHR-A--GTVSD----SELAARF--AQRDAMLCIVNSRKHAQALFAL----------
IRDLP-----GARHLTTMMCAGHRRVVLAAIRADL--A-----AKRP---TRLVSTSLVEAGVDIDFPEVWR
AETGLDSIAQSAGRANREGR-LADA-PVTIFTSAD--H-AT-PRM--FRQQVDAMDAALR--QYPHDP----
---LGLDAIRAYFNNLY----WTK---G-ID----RLD--------A-----------ARLDGRDYAILPAF
AE--SFAA-GGPRPAPPYASVAR---AFEMI-DETGRAVIVPWRG-DADPQEIDRLVAAIAA----AP--VP
PRAQLRRLQNYTVSVPERAYLA-MVAAGAVQP------IAPDRYGDRFMLVQDV-------G-LYADDTGL
>tr|A0A2E9ANC7|A0A2E9ANC7_9GAMM/2-740 CRISPR-associated helicase/endonuclease Cas3 OS=Salinisphaera sp. OX=1914330 GN=CMN27_15055 PE=4 SV=1
FYAHSTEC-SD-------ARDW-----QG---LADHLQAVADLAAKRAARFG--WENAGRAAGLLHDLGKYS
PAFQRRLS------------GSGER----VDH---STAGALEAKTRFPDG-------LGHLLAYAIAGHHAG
LANG--RDA---GTRT----PLSDRLV-------ADLPTLSR--RWREELV--LPDS----LHPDGAFH---
-----------QRRDRAFFQMAFLTRMLFSCLVDADFIETETFYTVVAGD-APPERGNP-----TSLSTLRD
ALNTHLDEL-----------AAKARKSPVNERRADILHHVRAAA--P-EPP---GHFSLTVPTGGGKTLASL
AFALDHAIAHGMDRVIYVIPFTSIVEQNAAVF-----------------RDALGAFGEDA--VLEHHSAFDE
DS-------RRGRQDRHSRDKLKRASENWDMPIVVTTAVQFFESLFAAKTSKARKLHNIANSVVVLDEAQTM
PLAVLRPSVAALDELALNYRTSIVLCTATQPAL-EETDNPAHSFA---------GGL----RDVRELAP---
-DPNSLAQQF-ERVTVRH-I--GTLDD----DGLTEEL--LDCEQALCIVNNRRHARALYES----------
IGDSP-----GAYHLTTAMCAVHRRQILAEIREVL--A-----SGSP---CRVVSTSLIEAGVDIDFPRVLR
AEAGLDSIAQAAGRCNREGRYKRDISEVRIFATSNEDW-AP-PPE--LKQFAQATREVLR--AHGEAP----
---LAPAAITAYFRLLY----WQK---G-PQ----ELD--------K-----------HDL-------LGQI
ET--A------QLDGLPFDMLEQ---KYRLI-ENTQRSVIIPY------DDRARRAIAGLSH----A---ER
VGGIARALQPYTVQVPIKGFHA-LEQAGVIAA------IEPDRFGDQFVVLIDEHPGELNTN-SYDPNMGL
>tr|A0A1M3GT59|A0A1M3GT59_9PROT/6-739 CRISPR-associated helicase/endonuclease Cas3 OS=Thiobacillus sp. 65-1059 OX=1895860 GN=BGO60_08550 PE=4 SV=1
PIAHAVQN-TD--------GSW-----RDPHDLDEHLTSVADLAAEFACAFG---PEWARLAGRWHDLGKYR
QRFQNYIRLASGFEADAHIRGEVGK----APH---STAGAILACDRFGA--------AGRVLAYLIAGHHAG
LADW--FG------------GLEGRLTTI-----DGRAELDE--ARAENPP---PHILDHGDFKPNLRA---
-----------IPGGRDGF--ALWVRMLFSALVDADFLDTERYMDAE----KFAQRNQW-----PTLDRLVP
RFDAHMAKF-----------AAQADPTPVNTLRADILRQCREKA--A-FAP---GLFSLTVPTGGGKTLSGM
AFALEHARTHSKRRVIHVIPYTSIIEQTADIF-----------------RSIFGEA------VIEHHSNAES
EP-------------SQENTASRLACENWDAPIVVTTNVQFFESLFAARTSRCRKLHNLVDSVVILDEAQLL
PPEFLQPILDVLRLLTRHYGVSVVLSTATQPAL-----STREYFDP----SQNLRGL----DDVREIID---
-DPDALYQAL-ERVNVRL-P--ADWQQPSEWPQVADEL--ARHDSVLAIVNTRKDARALWEQ----------
--LPE-----GTLHLSALLCGAHRSQRIAEIKARL--K-----SSVP---TRVVSTQLVEAGVDVDFPVVYR
ALAGLDSIAQAAGRCNREGR-LTEKGEVIVFIPPK--S-AP-PGL--LRKGENACKSVLY--GVTESP----
---LSRARFEQYFRQLF----AAC-----------KLD--------E-----------HGI-------CGDL
FM--ANDKLDGRELAVNFRTAAD---NFKLIRDEDSAPIIVLYRGTDGQDNSIDKWLATLRL----E---GP
QRWLMRKLQRYTVNIHRREAQA-LLQQGDIVE------LMPGL----YIQVSDW---------LYHPELGL
>tr|A0A2P7STP4|A0A2P7STP4_9RHIZ/3-744 CRISPR-associated helicase/endonuclease Cas3 OS=Mesorhizobium ephedrae OX=2116701 GN=C7I84_01710 PE=4 SV=1
FYAHSGTP-GD-------KSDW-----QP---LPEHLKGVAELAAANARPFG--MEKAVRVLGLFHDLGKYD
PQFQRRLE------------GADIR----VDH---STAGAAKLLELAKGQ----DRGTAELLAYAVLGHHAG
LPDK--------HNEFGH--CFKRRVR-------EYRDRLDP--AWKTQLGFGL-----SGLMPAFVSAR--
-----------VAKATAAFDLSVLTRFLFSCLVDADFKDTEKFYAEREN--RQVDRDWPAL--DRSLPDFIA
RFDAHMAAM--------------PADGTVNRLRRDILAHVRGRA--R-MAP---GLFTLTVPTGGGKTLASL
GFALDHAGAHGHRRIIYAIPFTSIVDQTADIF-----------------RKVLGGEH-----ILEHHSAIDD
EE---DRPRRKGERPPTSRDRLKLAMQDWAAPVVVTTNVQLFESLFAARTSRARKLHNIAGSIIILDEAQTM
PRHLLKPCMRMLDTMARLFGCTIVLCTATQPALGRERPDGRPGFP---------DGLD---LAGRELAP---
-DPEELSRKL-RRTRIER-V--GDMDN----MALVEAL--RSQDQALVIVNSRKHALELYQEA--------K
QAGLD-----GLVHLTTRQCAAHRRQILADVRTRLDPK-----AKHP---CRVIATSLIEAGVDVDFPRVWR
AQAGWDQVMQAAGRCNREGRRERDESVVSVFAPVG--Y-DP-PPE--IKALVKDTVRALD--RHSGDA----
---QSLEAIRSFFEEVY----WRL---G-DM----GLD--------S-----------KYI-------FDDF
IL--SL-----DGSSFAFRAAAE---KFRMI-ESKMEPVIVAI------DDTSRDAVKKLAI----EK--IS
SGNLARELQSYIVQTPPRAREM-LIRNGHVLF------EQPGLREMQFAVLKKD-------S-LYRKEVGL
>tr|A0A1Y4FWN4|A0A1Y4FWN4_9ACTN/4-752 Uncharacterized protein OS=Gordonibacter urolithinfaciens OX=1335613 GN=B5F44_06860 PE=4 SV=1
CYAHTGSDLDD-------ASTW-----QT---LSEHANEVARRAEAFAEKFG--MGLWGRTLGLLHDAGKAS
AGFRKRLE------------GGKP-----VDH---STAGAKIAVDRYGA--------GGWFMAYALIGHHGG
APNGKVWSECSRSQSAFLRIPLKNRLESEI----ESYDAFFE-LMETGEID--LPDIVQLGAPMRPGRTF--
-----------ESTARKAFSVFVLEHFLYSSLVDSDYLDTERFMTPEASEAREAREL-------ANMEELLA
KLESHMADL-----------MEKAGDTSVNRARRSVYEDCLATA--V-QPS---GLYTMTVPTGGGKTLSSM
AFGLRHAVEQGMERVIVAIPYTSIVEQTAATL-----------------KAIFGAEN-----VVEHHSNYDF
HD-----------LDDEEKAKQRLAIQNWDAPIVVTTNVQLFESLFSNKPGKSRKVHNMARSVVILDEAQTL
PDKLLRPSLAMLEELAAGYGSSIVLCTATQPAL---------------------EGLWPFGAEPREIVQ---
-RRDSFDEAFGERVAYES-L--GTIEQ----ADLVERI--AAHHEVLCVVGTRGLARAVYDDVVARAAERGD
LSDVKRAFDEGYFHLSAFMIPAHRSAMLERIRKRL--D-----RKER---CVVVSTQLVEAGVDVDFPEVYR
ELAGLDSVVQAAGRCNREGR-LPGAGTVRVFELSINGE-RQ-KTETWLEKMKGIARDVIR--ENGGK-----
---VEEGLIPAFFKTRY------D-----SE----CLD--------A-----------KGI-------FQKT
AT--R-DLIFDRFETMPFEQCAL---DYRII-EDDSVPVFVPW------GAEGRALLKELLA----S---KN
PAGMAMRLQRFSVGVPIWSIEG-YKQADAVEE------LEP------FLILKED-----GCRSFYREDVGL
>tr|U2KM65|U2KM65_TRELE/6-753 CRISPR-associated endonuclease Cas3-HD OS=Treponema lecithinolyticum ATCC 700332 OX=1321815 GN=HMPREF9193_01150 PE=4 SV=1
IIAHITED-GK-------SQT-----------LLEHAKAVAELASGFAAEFN--NADWAAAAAMWHDLGKAD
PSWQNYIR------------GKGSRT---VNH---AEAGAQYAYCNMQT-----RKPLEKTISYLIAGHHAG
LPDW--YAG---SGKSLK--SIFDRNDY------EEIIKISE---IKDICDFKLPSSVPFGLN---------
-----------KPSPDLFEHLHLWVRMLYSCLVDADFLDTERFMTPD----TFKLRGKF-----VDLTELKK
RFDVYMNEK-----------TAHTQATRLNEIRVGVLASCRKKA--R-CKP---GFFSLNVPTGGGKTLSSM
AFALEHALVHNRRRIIVAIPYTSIIEQTAKVYKYGTDVDALIEEYKKQDKYLFGEEN-----VLEHHSNFDF
DK----------KNEADILQRQKLATENWDAPVIVTTNVQLFESLFNAHSAHCRKLHNIVNSIIILDEVQML
PPDYLKSILSVLRRLVEYFGVTIVLCTATQPAFEGTIGSDAARFD----------GIPR--DLITSIID---
-NPAELTKEL-KRIKINT-D--YVREKIPDWKSLADKL--CDFEQVLCIVSTRKDCRDLHAL----------
--MPV-----GTIHLSALMCPEERSEIISDIKNKL--R-----NGEP---VRVIRTQLVECGVDMDFPVVFR
ALAGMDSIAQAAGRCNREGN-IKDLGVVYVFSPPS--R-IP-FGL--LRKGADATKSILE--KYDYKI----
--ELTPELYKEYFK-LY----FDS-----VN----DFD--------K-----------ADF-------ESAM
KK--E-----SKHENFQFRTLSD---TYHLIDSSYQSSVIIRYTSPKT-GKSNTALIDKLIA----D---GP
DRTVMRKLGRYSVNLPLKEITQ-LLQKGRL--------IQPFDDIAVYVQNQTD-------RNLYQPGLGL
>tr|G4E278|G4E278_9GAMM/4-736 Metal dependent phosphohydrolase OS=Thiorhodospira sibirica ATCC 700588 OX=765914 GN=ThisiDRAFT_0407 PE=4 SV=1
YFAHSTQT-DD-------KADW-----QR---LSEHLITTSKRAGEFAQPFG--AEEFASVAGLLHDLGKYT
QTFQERLK------------GGKLR----VDH---ATRGAMLAVEKFDQ--------LGYLLAYGIAGHHAG
LANG--REG---GERT----ALSDRLKG------TGLPPLHD--AWQGEIS--LPSK--LPWPPLD------
-----------IHKERGNFQLTFFVRMLFSCLVDADYLDTEAFYDRIASPEQTRQRSTARALESPSLEVLRE
QLNSYLCGF--------------SADTHVNRVRAEILSHTRNAA--P-QPP---GLFSLTVPTGGGKTLASL
AFALDHAIEHGLRRVIFVIPFTSIVEQNAAVF-----------------RAALGKYGEAA--VLEHHSAFVT
AQ-----PAHAEAERYQSREKLRLAMENWDAPIIVTTAVQFFESLFAARPSQCRKLHNIAGSVVILDEAQTL
PLKVLRPTVAAIDELARNYRSSIVLCTATQPAL------NAPEFA---------GGL----ENVRELAP---
-KPAQLFRTL-ERVRVRH-V--GTLED----DALTAQL--RALDRVLCIVNNRRHARAVYQS----------
LADLP-----GSRHLTTLMCAKHRSEVLAEVRARL--K-----ADKP---CRLVSTSLIEAGVDISLPTVYR
AEAGLDSIAQAAGRCNRNGERAAELSEVRVFATANSDW-AP-PPE--LRQFAEKAREIMRQPQFRDDP----
---LSPPAIEAYFRLLY----WQK---G-DK----ELD--------A-----------ANL-------LGLC
AG--S------PIDTLPLETLAA---KFRII-ETVQMPVIVPF------NDEARQLINSLRH----A---QS
SGSLARKLQLYLVQLPRDKFDA-LRKAGAVQP------IAPEKWGEQFMELVNQ-------D-LYNQQFGL
>tr|C9P896|C9P896_VIBME/4-747 CRISPR-associated helicase Cas3 OS=Vibrio metschnikovii CIP 69.14 OX=675813 GN=VIB_002738 PE=4 SV=1
YFGHSGNK-ED-------KSDW-----QP---LQDHLCRVALCAELNSKYFK--AAKLSYLAGLLHDLGKYT
PEFQARLE------------GASSK----VDH---ATAGAKIAAEILPDEKFN-NFPFYKFVAYAIAGHHAG
LSNG--TGE---GDGR-R--ALKDRLELQFG---KDLPVLDS-ETWQSELV--LPSI--ESLIPEISPN---
-----------PDADLQGFQYAFLIRMIFSCLVDADFIDTDEFYKRLEG--KPLLRGDY-----PQLSELKI
QFDQKLADK----------IKSTDQTKTVNQLRKEILDTARLKA--K-LTP---GLFTLTVPTGGGKTLSSM
AFALEHALAHNMRRVIYVIPFTSIIEQNAQVF-----------------RDAFGELGEAS--VLEHHSNFDD
RK------IKDKEGAEETRDKLKLAMENWDMPVVVTTAVQFFESLFADRPSRCRKLHNISGSVIILDEAQTL
PLKFLRPVMAVIDELARNYGCSIVLCTATQPAL------CEPDFT---------NGF----TNVREIAP---
-EPKRLFDEL-SLVSVSH-L--GELSD----DELVSRI--QANNQILTIVNNRRHAQSLFRTL--------N
TQQTV-----GVFHLTTLMCPAHRTATLDEIRKRLDPK-----KPQP---CRVISTSLIEAGVDVSFPCVMR
AEAGLDSIAQAAGRCNRERLWGKEDSHVWIFRSPD--W-PI-PPE--LKGLSADMRAVLR--KGHDNL----
---LDQLAIKEYFSNVY----WRK-----GE----ELD--------Q-----------KQL-------LKAC
RI--G-----ASKLDFPFQSIAS---VFRMI-DSFMCPVLIPY------NDEARKLLNELES----T---DD
VSCVLRKLQPYIVQIPQNGFDS-LRLAKVIQT------VAPYRFEEQFWELVNM-------D-IYHPKSGL
>tr|A0A4Y6L053|A0A4Y6L053_9RHOO/11-742 CRISPR-associated helicase/endonuclease Cas3 OS=Azoarcus sp. DD4 OX=2027405 GN=CJ010_02255 PE=4 SV=1
FFAHSTAL-AD-------RSDW-----QP---LAHHLQNVAAMAARFASIFN--AAGLAAPAGLLHDIGKYT
EDFQRRIA------------GEAVR----VDH---ATRGAMLALQQYPD--------LGYLIAYAIAGHHAG
LANG--IES---GERT----SLKERLRG------VGLPPLLP--VWQEEIQ--LPAN--LGELPFKK-----
-----------AGSGGPMFQAAFLVRMLFSCLVDADYLDTEAFYDGVAQPGEPNDRNVLRALEAPRLEALRE
RLDAYLATF--------------TADSEVNRIRVDILAHVRGEA--V-RDP---GLFSLTVPTGGGKTLASL
AFALDHAIRHGLQRVIFVIPFTSIVEQNAAVF-----------------RRALGDLGESA--VLEHHSAFVQ
PP-----PTRDDAERYQSQEKLKLAMENWDAPIVVTTAVQFFESLFAARPSQCRKLHNIAGSVVVLDEAQTL
PLKLLRPAVAAIDELARNYRSSVVLCTATQPAL------KAPEFV---------GGF----ESVRELAP---
-EPPQLFRKL-ERVRVRH-V--GELDD----EALAAHM--RAHEQVLCIVNNRRHARAVFQG----------
MADLP-----GARHLTTLMCASHRSKVLAEARDDL--K-----SGRP---CRLVSTSLIEAGVDVDFPLVLR
AEAGLDSIAQAAGRCNREGRRDAAASEVLVFSTANPDW-AP-PPE--LKQFAQAAATVLR--SHAADP----
---LCPAAIEAYFRELY----WRK---G-ES----ALD--------G-----------GGL-------LGLL
RS--S------RLDSLPLETLAT---RFRMI-DSVQMPVIVPY------DDTARDALKALRY----V---EK
SGGIARSLQSYLVQLPRQGFEA-LRKSGAIQP------VAPERWGEQFMALTVM-------D-IYSKDFGL
>tr|A0A380NP55|A0A380NP55_VIBME/4-747 CRISPR-associated endonuclease Cas3-HD OS=Vibrio metschnikovii OX=28172 GN=NCTC8563_00614 PE=4 SV=1
YFGHSGNK-ED-------KSDW-----QP---LQDHLCRVALCAELNSKYFK--AAKLSYLAGLLHDLGKYT
PEFQARLE------------GASSK----VDH---ATAGAKIAAEILPDEKFN-NFPFYKFVAYAIAGHHAG
LSNG--TGE---GDGR-R--ALKDRLELQFG---KDLPVLDS-ETWQSELV--LPSI--ESLIPEISPN---
-----------PDADLQGFQYAFLIRMIFSCLVDADFIDTDEFYKRLEG--KPLLRGDY-----PQLSELKI
QFDQKLADK----------IKSTDQTKTVNQLRKEILDTARLKA--K-LTP---GLFTLTVPTGGGKTLSSM
AFALEHALAHNMRRVIYVIPFTSIIEQNAQVF-----------------RDAFGELGEAS--VLEHHSNFDD
RK------IKDKEGAEETRDKLKLAMENWDMPVVVTTAVQFFESLFADRPSRCRKLHNISGSVIILDEAQTL
PLKFLRPVMAVIDELARNYGCSIVLCTATQPAL------CEPDFT---------NGF----TNVREIAP---
-EPKRLFDEL-SLVSVSH-L--GELSD----DELVSRI--QANNQILTIVNNRRHAQSLFRTL--------N
TQQTV-----GVFHLTTLMCPAHRTATLDEIRKRLDPK-----KPQP---CRVISTSLIEAGVDVSFPCVMR
AEAGLDSIAQAAGRCNRERLWGKEDSHVWIFRSPD--W-PI-PPE--LKGLSADMRAVLR--KGHDNL----
---LDQLAIKEYFSNVY----WRK-----GE----ELD--------Q-----------KQL-------LKAC
RI--G-----ASKLDFPFQSIAS---VFRMI-DSFMCPVLIPY------NDEARKLLNELES----T---DD
VSCVLRKLQPYIVQIPQNGFDS-LRLAKVIQT------VAPYRFEEQFWELVNM-------D-IYHPKSGL
>tr|A0A3D5EMN6|A0A3D5EMN6_PSEAS/4-749 CRISPR-associated helicase/endonuclease Cas3 OS=Pseudoalteromonas sp. OX=53249 GN=DG048_21590 PE=4 SV=1
YFAHSGNK-SD-------KSDW-----QS---LKDHLAIVAEISEHNGRYFK--ANKLCYLAGLLHDLGKYT
AEFQRRLE------------GNPQK----VDH---ATAGAKIAAELLRDKHFN-QFPFYKFVAYAIAGHHAG
LANG--SAE---GDDR-R--ALKDRMNLKFG---KELPVLDH-EVWKAELE--IPPI--ESLLPKIAVN---
-----------PDAERQGFQFAFLIRMIFSCLVDADYIDTDKFYRSLKN--KALLRGKY-----PQLSELKK
RLDQTLTDM----------LVKCDQAKKVNQLRKEILDNARYKS--K-LSP---GLFTLTVPTGGGKTLSSM
AFALDHALAHGMRRVIYVIPFTSIIEQNAKVF-----------------REAFGDLGDAA--VLEHHSNFDD
RN------ILGKEGAEETRDKLKLAMENWDMPVVVTTAVQFFESLFADRPSCCRKLHNISGSVIILDEAQTL
PLKFLRPTMAVIDELARNYNCSVVLCTATQPAL------CEPDFD---------KGFRE--EDVREIAP---
-DPERLFEEL-SLVSVSH-L--GELTD----DELLSRI--QTNEQILTIVNNRRHAQSLFQTL--------K
KQQTE-----GVYHLTTLMCAAHRTETLELVRERLKPE-----NALP---CRVISTSLIEAGVDVSFPCVMR
AEAGLDSIAQAAGRCNRERIWNKDDSHVWIFKSPD--W-PI-PPE--LKGLSADMRAVLR--KEHGNL----
---LDQAAMKDYFSNVH----WRK-----GE----ELD--------Q-----------KQI-------LKAC
RV--G-----ASKLDFPFQKIAK---DFRII-DSVMQPVFIPY------DDASRSLLEQLKT----T---DD
VSGTLRKLQPYVVQIPQGGFDS-LQVAKVIQP------LAPHRFAEQFWGLINM-------D-IYDSEFGL
>tr|A0A351ZDS1|A0A351ZDS1_9FIRM/2-759 CRISPR-associated helicase/endonuclease Cas3 OS=Ruminococcus sp. OX=41978 GN=DCZ62_02810 PE=4 SV=1
FTAHIRET-DN-------AC-------QT---VGQHSRNVSALAEGYLRPVS--LSQVGRLAGLLHDAGKLR
QLFDDYIH------------KRNSLTRGSIDH---SYAGARILRELAKNGDKQ-LQTAAEAVGHTILSHH-G
LNDW--LDP---DGES----VFRRRTDKDEGFG-EIMGNLSE--VCTMAEAEELLAAAKAEWFQAAKKLMC-
-----------QNKEEFTFYMGMLERLIQSALIDADRTDTADFMSAGE---TPPEPDNS-----ALWQAMDQ
RMEEKLRGF-------------SHLTDKISIQRRSISDRCAKFA--Q-HRV---GACRLIVPTGGGKTLSSL
RFAVKQCRNFGLKRIVYVAPFMSILEQNSDVI-----------------RELAGQEN-----FLEHHSNMIP
EI-----------DDPSALKQYLLYAERWDRPVIATTMVQFLNTLFSAKTSSVRRMHRLCDSVIIIDEVQSV
PIKCTDLFSLAVNFLVKQCGAAVVLCSATQPPF-----DQKGKFP---------LIL----DEEKDMAG---
-DCTKDFQVF-RRTEITPLLKKYGYEMEEAAELCCEKF--RENGDLLLIVNTKAQAREMYRRL------KES
LEGEA-----YLIHLSTNMCPAHRKKRIGTLRRFL--K-----RNKP---VICVTTQLIEAGVDISFRCVIR
AIAGLDNAAQAAGRCNRSGE-YNRICPVYLINFKAENL-RG-LEE--IKTAQRVSRQIID--NCDHDL----
---LSVDVQTSYFTELF----RQY-----SD----KLSYNVSDGSSQ-----------TNLVELLSTDEKRF
IL----RKETEPVLSQAFKTAGE---LFSVI-DSNTKDIIVPY------NKQAEWLISRLES----QISPIE
ARELLRKAQKYTVSIYAGTEKA-LSEKGALHL----------------NTLDKR---------FYNNEFGV
>tr|A0A2A4HPQ3|A0A2A4HPQ3_9GAMM/8-735 CRISPR-associated helicase/endonuclease Cas3 OS=Halomonas nigrificans OX=2042704 GN=CPA45_03215 PE=4 SV=1
FYAHSLPE-TD-------KQAW-----QT---LDDHLQCVAEMAATRAERFG--MADAGYAAGLLHDLGKYS
APFQRRLE------------GSPER----VDH---STAGAIVAKQRFKGG-------IGDLLAYCIAGHHAG
LANG--RDS---GERS----PLSERLK-------ADIPAIDN--AWQEAIT--LPQE----LRPPGTFT---
-----------QRPERGFFQLAFLTRMLFSCLVDADYIDTETFYAQHENG-LARQRGGG-----ASLTHLRE
ALKQHLETF--------------DTEKGINQLRGHILREVRNKA--G-MRP---GCFSLTVPTGGGKTLASL
AFALDHAITHGMDRVIYVIPFTSIVEQNAAVF-----------------RKALSQYGAEA--VLEHHSTFDA
EK--------ASKGDKDSLDKLRRDSENWDAPIVVTTSVQFLESLFAAKTSRCRKLHNIARSVVILDEAQTM
PLPLLRPSVAALDELTLNYHASIVLCTATQPAL-LETNDAARSFT---------GGF----KDVEELAP---
-DPKNLYRKL-KRVTVKH-M--GCLDD----DQLRHEL--LDVDQVLCIVNNRRHARALYES----------
IADQP-----GAFHLTTAMCAVHRRQVLHHIRGTL--K-----EGKP---CRVVSTSLIEAGVDVDFPRVLR
AEAGLDSIAQAAGRCNREGKRTTAESEVRIFATANEEW-AP-PPE--LKQFAQATREVLR--QHGHDP----
---LSLEAIEAYFTLLY----WQQ---G-PD----QLD--------K-----------HQL-------LSLI
EN--G------RLEGLPFETLEK---TFRLI-DNNQRSVIIPR------DADARKAIKELAF----A---TS
PGGIARKLQLYTVQVPHNGFRA-LEKVGAIAP------IEPDKFNDQFMLLVNE-------D-LYHDALGL
>tr|A0A4Y3W7N8|A0A4Y3W7N8_NITWI/2-736 CRISPR-associated helicase/endonuclease Cas3 OS=Nitrobacter winogradskyi OX=913 GN=NWI01_08960 PE=4 SV=1
YYAHSTKN-TD-------GSDW-----QR---LADHLQQVTRLAAARGDKFG--AGRAAALAGWLHDLGKYA
AAFQNYIS----------HRGPGG-----VDH---STAGAKEVIALGLKEG---DGLMAELIAYAIAGHHAG
LPDK-------SGDAS----TLADRFE-------KPLEPLDA--RWRREVD---FDA--TELMPKDFTW---
-----------RRDGRHAFQAALLGRMIFSCLVDADFLETEAFYASVDG--NEIDREWPKL--PDQMDRLIA
AFDAYMADK-----------QRSAALTPLNQLRGEILTHVRARA--A-LPR---GVFTLNVPTGGGKTLASL
GFALDHAKRWGMERIIYSIPFTSIIEQTASIF-----------------REVLGNNV-----ILEHHASIEQ
TS-----SKDDEFRDGISDARLRLAMENWPAPVVVTTNVQLLESLFASRTSRCRKLHNLANAVIILDEAQTI
PLHVLKPCVAVLDELALNYGCTIVLCTATQPAL------IAPSFD---------GGFQIVDPDERELAP---
-DPPRLHREL-KRTTERL-A--GTMTD----DDLVHEM--AAVEQGLVIVNSRQHALMLYQAC--------E
AAGLA-----GLIHLTTRQTAADRRVILADARQRL--T-----HGQL---CRVVATSLVEAGVDIDFPRVWR
AQAGLDQMMQAAGRCNREGRRLVRDSIVTIFEPAE--A-KP-PPE--IAGLIDDTSRILR--EHRSDL----
---FSPRAIEAYFREVY----WRK-----DK----GLD--------K-----------RAV-------MQRF
LI--G----VGDKTDFAYRSVAE---EFRLI-ESGMAPVIIAV------DDQAKATLVALKG----G---MP
PGMAARELQNFVVQVRPRDRRL-LLGNGHVRF--------VEGFGDQFAVLMTE-------S-LYSRETGL
>tr|A0A2M9G0I8|A0A2M9G0I8_9PROT/49-773 CRISPR-associated endonuclease Cas3 OS=Minwuia thermotolerans OX=2056226 GN=CVT23_13105 PE=4 SV=1
FFAHSTPS-AS-------EAEW-----HR---LADHLSSTSRHAENFARHFA---PDAAAVAGLLHDLGKYS
PAFQARLR------------GDPKR----VDH---STAGAIEAMRLYGP--------LGKLIAYAVAGHHAG
LANGAGHE----GERR----PLVDRLA-------DTPPPLDK--TWQSEIG--LPPG--LGEPELAT-----
-----------RSADRAGFQFAFLTRMLFSALVDADYLDTEAYYARIEG--REHVRGGY-----PSLAPLRE
ALDAELAQL--------------SVEGPVNELRQRVLAHVRGQA--A-GKP---GLFSLTVPTGGGKTLTSL
AFALDHALANGLERIVYVAPFTSIIEQTARVF-----------------RTSLGALGEAA--VLEHHSAFED
EK----------IGGREAADKLRLAMENWDAPVVVTTAVQFFESLFADRPSRCRKLHNLAGAVIVLDETQTL
PLAHLRPCVAAIDELALNYRSSVVLCTATQPAL------NESDDPA----RSFAGGL----RGVRELVP---
-DPPALHTSL-RRVTVRM-A--GQLDD----EALAEQL--LAREQVLCIVNNRAHARAVFER----------
LRGEP-----GARHLTTLMYPRHRARILREVRADL--T-----AGRP---CRLVATSLIEAGVDVDFPAVFR
AEAGIDSIAQAAGRCNREGRRHRTDSIVTVFRPVG--W-NP-PPE--LARFAEVAAEVLR--RHKADP----
---LGPDAIDDYFRQLY----WLREL-A-GS----GLD--------T-----------ARI-------IARC
DT--G-----ARSLDFPFESIAK---EFRII-ESAMQPLIVPG------DERACGLVRRLAW----S---ER
PGGIARKLQPYVVQLLPRQIAA-LMANGNILA------LNHEHLGNQYLKLSNM-------A-AYDPECGL
>tr|A0A371WZ41|A0A371WZ41_9RHIZ/3-755 CRISPR-associated helicase Cas3 OS=Fulvimarina endophytica OX=2293836 GN=cas3 PE=4 SV=1
FYAHSIEG-KA-------PERW-----EP---LVDHLEAVAAQARCFGDEIG--IARLCELAARLHDLGKFD
PRFQRYLA------------GARER----VPH---SIAGAAAIVDRGETPG---EKAVAMLIAQAIAGHHAG
LPDR--TG----SDGA----SLAERKAA------FDFASLSG--SWHYFIPQNL-----DGLGMTFAGS---
-----------GSKREEAQRYAMLGRMIFSCLVDADFLETERFYVERGE--RRRDRDWPSL--ADCLPRFQR
RFEARIAGF-------------DPAASEIAGLRHEILTSARERA--RTLEP---GLFTLDVPTGGGKTLASL
GFALDHAEKWGHRRIIYGIPFTSIIDQTAEIF-----------------RDVLGADA-----ILEHHSAIED
ER--LDRSLEDADTRRSGKDKMRLAMENWAAPVIVTTHVQLFESLFAARTSRARKLHNIAKSVIILDEAQVL
PKHLLAPTVRAIDVLARDWGCSIVLCTATQPAF------DASNFPE-----RHPLALD---LEGRELAP---
-DPKRLHAAF-RRNRLVQ-A--GEMDD----EALVAAL--GDEPQALIIVNSRAHALELFTLA--------H
EAGLD-----GLVHLTTRQCAAHRHAILKDVRARL--T-----NGEP---CRLIATSLVEAGVDIDFPKAWR
AEAGLESIIQAAGRVNREMKRDAEACTVTVFKPAG--R-KP-PFE--IAALVRDTQNVAR--RQP-DL----
---FMREAIDDYFGEVY----WRM---G-EE----GLD--------AAPLGPIADGETRGI-------LRQM
AH--T----KVQGLDIVYRTIAE---RYRMI-ENGMAPIVIAR------DEKAKAAVEKLSL----PD--VP
SGAVARELQSYIVQVPPKARAL-LVATGHVVF------GHPELRGDQFAVLRTQ-------T-LYREEIGL
>tr|A0A511WXW9|A0A511WXW9_9BACI/8-799 CRISPR-associated helicase/endonuclease Cas3 OS=Halolactibacillus alkaliphilus OX=442899 GN=HAL01_04280 PE=4 SV=1
YIAHIRST-DR-------QI-------QT---VRQHLIETKEICEKIGNKIH--MKHVAGLAGLLHDMGKFT
TGFKNYIMQAVNDPENAPIRGS-------IDH---STAGGRLLFEKYYNNHSV-NKIMVEIIGNGILSHHGY
LQDY--LNS---NLEL----KFLNRIKD------KELEDYNE--AKINFFLEVMSEKEIENYVNIALNEMNQ
FLNK-------IKEPNYSTTIMLLTKYIFSALIDADRTSTRCFEDNISYNEQFTHHSFE-----KDYEKLLC
EIDALNNNS--------------VNITPINKLRQKMSDECDQVA--S-KAS---DVFTLSIPTGGGKTLSSL
RYALKHAVKYNKKRIIYIVPYTTIIEQNAEVV-----------------RNLLRNTTT----LVEHHSNVFY
EN-NNNSEDEIDEEVMTIENKLLLARDNWDAPVIFSTMVQFLNIFYSSGTRNIRRLHNLSESVIIFDEVQKV
PVKCIALFNATVNFLNNYCDSSIVLCTATQPAL------KDVEHN---------LMI----GKDTEMIS---
-RIDDVNEAF-KRVEICDIATGNQLSTVELADFIEKQT--CEVTSQLVILNTKSVVKKLYHVL--------K
ERLED----TKVYHLSTSMCASHRRDILKNVHKEL--E-----SNQP---VICLSTQLIEAGVDISFQQVVR
SLTGLDSIAQAAGRCNRHGE--CKLGRVYLIDHKEENL-SR-LPE--ISIGKDITKKMLI--DLSKDSNVFK
GNILSRNAMEYFFREYY----SEL-----SF----EIDYNIPSLNVKMTDLLLTNNNKSKW-------YMEF
TN--KFKTGYPLFSHGSFQTAAK---NFNAI-DSVTTSVIVPF-------KEGREIIADING----EKRIED
ISILFKKAQHYSVNLHANEFNL-LRSVGAVMD----------YFEGKLFALAEG---------FYSEEVGL
>tr|A0A0U3ES66|A0A0U3ES66_9RHOB/3-757 CRISPR-associated protein Cas3 OS=Pannonibacter phragmitetus OX=121719 GN=APZ00_20175 PE=4 SV=1
YYAHSAPD-AD-------EAGW-----QE---LPEHSLQTAGLASEFAAVFG--GGKAAYLAGLLHDLGKYN
TEFLAYIR------------GQLHRGGKGPDH---STDGAGVFLRAAAGEANPMDGVILELLAHAVAGHHAG
MPDR--TRSVQSGGAG----ALQERLER------WDDTRLDP--IWKDELNAEF-----GGLFPPDFHMDPR
ITKT-------HPIAARTFQIAFLGRMLFSCLVDADFKDTEAYYNQLKG--ITADREWPDL--QDVLPELQA
RFNREMAAK-------------AGASGPLTSLRGEILAHVRGRA--A-EPA---GVFTLNVPTGGGKTLASL
GFALDHAAHHGHRRIIYAIPFTSIIDQTAAIF-----------------RHVLGDEV-----ILEHHSAIEE
DR----------LQELGQRDKLKLAMEDWAAPVIVTTNVQLFESLFANRPGRCRKLHNIAGSIIILDEAQTL
PLPYLKPSVLALDELARNYGCTIVLCTATQPAL------DRRDFP-----EGSLMGLE---LDNRELAP---
-DPARLAREL-RRTAIRR-A--GVLSD----DDLVRDL--TDHPRALVIVNSRKHALELFSAA--------R
AAGLE-----GLVHLSTRQCAAHRQALLARVRTML--E-----GNSP---CRVVATSLIEAGVDVDFPRVYR
AEAGLDQVLQAAGRCNREGSRAPDDSHVLIFKPEV--A-QP-PEE--LAQFAAAFASIER--RHT-DL----
---FSPEAIRDYFQEIY----WQR---G-ANDGKSGLD--------A-----------KGI-------LAMA
RM--DK-----SGTNIAYRTIAQ---EFRMI-ESGMLPVIIPY------DDHARHWIGQLDV----ES--VP
SGQIARELQRYVVQVPPKVRTD-LIANGAASV------RAAHLRADQFVVLEAS-------CKLYTPDVGL
>tr|A0A0K2D980|A0A0K2D980_9RHIZ/2-758 CRISPR-associated protein Cas3 OS=Chelatococcus sp. CO-6 OX=1702325 GN=AL346_02915 PE=4 SV=1
YYAHSTED-GH-------RGNW-----QP---LREHLEDTAVRAAAYGAAFK--AGKAARLAALLHDLGKYT
PGFAARLD------------GSKVP----VDH---STAGAALVLALAKGD----DRLIGELIAYVIAGHHAG
LPDK----Q---GESL-A--TLSERLKG------FSDASLDP--VWRAEIA---PDA--SGLVPA-FRWEPP
PARGAAPAEADAVRARLAFQFAFLGRMLFSCLVDADFKDTEGFYCRVEG--RQVDRAWPAL--QAILPELLA
RYARRMEAL-------------GSRDTMVNSVRSAVLDHVLSRA--G-EAP---GLFTLTVPTGGGKTLASL
GFALDHARIHGHRRIIYAIPFTSIIDQTAAIF-----------------RELLGGEV-----VLEHHSAIDE
AR-AERAPAAAADSEAASRNKLRLAMEDWAAPVVVTTNVQLFESLLAARPGRCRKLHNIAGSIIILDEAQTL
PRPLLAPAVAALRELATNYGCSIVLCTATQPAL------DAGNFP-----AGHPVGLP---LAGRELAP---
-EPQDLARKL-RRVTLRF-A--GKMDD----AALVAAL--MDQSQGLVVVNSRKHALALYQAG--------Q
EAGLD-----GLVHLSTRQHAADRRAILADVRQRL--K-----DGHP---CRVIATSLVEAGVDLDFPRVWR
AEAGLDNVAQAAGRCNREGRRPVDESIVTIFTAPD--H-PP-PPE--IKSLSGDLGRMAD--KHE-DL----
---LSPQAMEDFFGEVY----WRV---G-PE----GVD--------K-----------KKI-------LADF
RM--HRGE-HGPETIFAYRCVAE---KFRMI-ESGMEPVIVAN------TPEAWSIVERLGS----AA--IP
SGALARELQPYIVQVPPKARAL-LLANGHVVF------RAAEQRGDQFAVLMTG-------S-LYRPDIGL
>tr|A0A0J6S054|A0A0J6S054_9RHIZ/4-741 Uncharacterized protein OS=Methylobacterium aquaticum OX=270351 GN=VP06_27350 PE=4 SV=1
VYAHSVPN-QS-------IAQW-----EL---LADHLARVGDTAARFADVFG--WGELARLAGTLHDVGKMS
EIFQAYLH------------GRASS----CDH---STAGARVATAEYPH-------PVGRMLATIIAGHHAG
LDDG-------------D--GIDRRLDPHQ----TEIPAFEG---WRSHAAA-LPPM--GRLSP-TRRF---
-----------IQSTLPGFTHAFLTRMLFSCLVDADFLETERFYAGS----RPVPRGGY-----PGIAALQV
RLRAHMDGL-----------SAKARPGPVNAVRAEVLAAVRERA--A-LSP---GLFTLTVPTGGGKTLASL
TFALDHAARHGLRRVVHVAPFTAIIEQTAAVF-----------------RTALGDDAG----ILEHHATFDW
QA--AAARTVDDGIGLDPVSRLRRAAENWDAPVVVTTAVQLFESLFANRTSRCRKLHNLAGSVIVLDEAQAM
PLPLLRPCLAAIEELTRNYGASVVLCTATQPAL-----RRIDGFE---------PGLPV--DDARELAP---
-DPPRLYRAL-RRVAVERLP--GPTKD----EAIARRF--AEVPRMLCIVNSRRHAKALFDR----------
IAHLP-----GAVHLSTLMCPRHRKVVLDAARAAL--R-----DGGP---VRIVSTSLIEAGVDIDLPEVWR
ATAGLDAVAQAAGRCNREGA-MAGAGRVVVFDPAD--A-PP-PRE--LEPFRRAAEEVLR---AGGDP----
---LAPDAIRAYFAALY----WRK---G-EH----AFD--------A-----------PRLDEEIWPILPAV
AE--R-----AKTWAFPFASIAR---AFRVI-DDAMEPVIVPWRA-DSDDGRAETLLARIAA----MD--RP
LGDDLRRLQGYVVPVPPTLRAR-WLAVGRLRP-------VHSRLEGALLRLDDM-------A-FYESRSGL
>tr|A0A139SJ86|A0A139SJ86_9GAMM/8-738 CRISPR-associated protein Cas3 OS=Ventosimonas gracilis OX=1680762 GN=AXE65_07000 PE=4 SV=1
FFAHSTNP-AD-------KSDW-----QL---LKGHLSCVGELAARNAAHFD--AAHLARPMGLLHDLGKYT
NAFQKRLS------------GEFPK----VDH---STWGARIAQKEYGE--------LGLLMAYGIAGHHAG
LANG--RRR---KAR--T--TLQERLQ-------NELPKLLP--QWKTEIN--LPDAAEINKLPKDFK----
-----------ICSERVAFQFALLTRMLFSCLVDADFIDTDNFYRRIEG--RPARDGTSR----PSLAQLRE
RLDARLSDF--------------RGDSEVNRLRAGILSHVRGQA--A-HEP---GLFSLTVPTGGGKTLASL
AFALDHAIAHGLRRVIFVIPFTSIVEQNAQVF-----------------REAFGELGESA--VLEHHSAFVD
DP---EKFVDDPEKSAQSREKRQLAMENWDAPVIVTTAVQFFESLFADRPSRCRKLHNIAGSVVILDEAQTL
PLKLLRPCVTLLDELTLNYRTSIVLCTATQPAL-----NDADGFR---------NGL----KGVRELAP---
-DPADLYRRL-RRVNVRH-L--GTLDD----EALAGHL--RQREQVLCIVNNRRHARALFDA----------
IADQP-----GACHLTTLMCAKHRSAVLGEIRQRL--K-----DALP---CRLISTSLIEAGVDIDLPTVLR
AQAGLDSIAQAAGRCNREGRREPADSEVLVFATANPDW-AA-PPE--LKQFAQAFRSVEP--RYRDDL----
---LAPEAIRAYFREIY----WQK---G-DK----ELD--------A-----------CGL-------LDLL
KA--S------REDSLPFENLAS---DFRLI-ETTMRPVIIPW------DDIARDALAKLPF----A---QG
CGAIARRLQPYVVQLPKQAYDA-LSHAHAIQA------VRPDIYGEQFMQLVNP-------R-LYDERFGL
>tr|A0A0M1P0X1|A0A0M1P0X1_9BACL/3-795 CRISPR-associated protein Cas3 OS=Paenibacillus solani OX=1705565 GN=AM231_01250 PE=4 SV=1
YIAHIRES-DH-------QD-------QY---VEDHLHGVQSLAEQYGERIG--IKHIAGLAGMLHDMGKYT
DKFRDYILEAVRNPDAPPRRGS-------VDH---STAGGRLLYQLFHNKE---KGLMAEIVGNAIISHHSY
LHDF--IDP---NLEL----KYLQRVRDK-----QDIEDYDK--SVELFFERVISEKDFNAYVDRAVEELKQ
FRAV-------PSTLSSEAKCMFLSKYIFSALIDADRTNTRQFEEIVTEGMESTVPPD------ELFPVYYG
RLVNEIQSF----------SEQASAQSPIHLLRSQMSEQCDQFA--D-NPS---GIYTLSIPTGGGKTLASL
RYALKHAIKYNKKRIIYVLPYTTIIEQNAAEV-----------------RRILQDEAH----ILEHHSNVIE
ED---DEDDEQNDGIMNVRQKLKLAKDNWDTPIIFTTMVQFLDVFYAKSSKSIRRLHNLSESVIIFDEVQKV
PVSCVSLFNEALNFLSAYCHTSIVLCTATQPAL---------DFV------QHKLNV----SPNAEIIH---
-NLEHMIEAF-KRVEIVDYATNNAYTNDTLAALVTDKI--QEKQSVLVILNTKSVVKNLYKEL--------K
AASPD----IAIFHLSTSMCSAHRKVILDIIRERL--K-----NGEK---LICISTPLIEAGVDVSFECVIR
SLAGLDSIAQAAGRCNRHGE--KELQEVYVIDHAEENL-NH-LKE--IKLGKKITQRMLI--DLQRDPACYG
GHLLSLQAMKSYFQNYY----TDM-----QS----LLDYRIPKIGRSVTSLLFAKPVDNNY-------LQDY
QT--NRNQRPPQFLMNSYRTAAQ---YFHVI-DNPASSVIVPY------GEEGPEIIAELNG----AGRIED
FTRLLRRAQQYTVNLFDYEIQK-LDKNGGIRA----------CLDGQMLVLTDG---------AYHEEFGL
>tr|A0A2R4BRD6|A0A2R4BRD6_THAAR/11-742 CRISPR-associated helicase Cas3 OS=Thauera aromatica K172 OX=44139 GN=Tharo_3018 PE=4 SV=1
MFAHSTTN-SG-------RSDW-----QP---LRSHLENVGRMAKERAAIFG--AHTLAETSGLLHDLGKYT
ADFQRRLA------------GDAIR----VDH---ATRGAMVAIERYGP--------LGYLIAYAIAGHHAG
LANG--LES---GERT----ALRERLRG------TGLPPLLP--QWQDEIR--LPEA--LGELPFTG-----
-----------GAAGGAMFQAAFLIRMLFSCLVDADYLDTEAFYDRIAPPDQRGDRSRLRAVEQPSLEALRE
SLDASLARF--------------SADSDVNRIRADILAHVRNGA--Q-HTP---GLFSLTVPTGGGKTLASL
AFALDHAIRHNLRRVIFVIPFTSIVEQNAAVF-----------------RRALGELGETS--VLEHHSAFIA
PQ-----LSRDDAERYQAQEKLSLSMENWDAPIVVTTAVQFFESLFAARPSQCRKLHNIAGSVVILDEAQTL
PLKLLRPAVAAIDELARNYRSSVVLCTATQPAL------QAPEFV---------GGL----ERVRELAP---
-EPPALFRKL-KRVRVKH-V--GELDD----EALTDRM--RAHEQVLCIVNNRRHARAVFQT----------
MSDLV-----GARHLTTLMCARHRSEVLAGVREDL--R-----QGRS---CRLVSTSLIEAGVDVDFPLVLR
AQAGLDSIAQAAGRCNREGRRAVAASEVLVFSTANPDW-AP-PPE--LKQFAQAASTVLR--SHTNDP----
---LSPAAIQAYFRELY----WQK---G-SA----ALD--------C-----------TDL-------LGLL
QR--S------RPDSLPMETLAA---RFRMI-ESVQMPVIVPF------DKVAREALQALRF----A---DK
SSGLARRLQSYLVQLPRQGFEA-LRKSGAIQP------VAPERWGEQFMELTVM-------D-LYDECFGL
>tr|A0A1V8MAZ3|A0A1V8MAZ3_9GAMM/14-751 Uncharacterized protein OS=Methyloprofundus sedimenti OX=1420851 GN=AU255_06440 PE=4 SV=1
FYAHSTER-SD-------KNDW-----QP---LKQHLVNVGELTEGFAAAFN--CAEYGKIAGLLHDLGKYT
VEFQQRLE------------GKHPR----VDH---ATWGAKIALDKYGN--------GGYFMAYSIAGHHAG
LANGDYRED---KKLT----PLKQRCDN------PNLPILNS--VWQTEIDPLLPQK--LSTPPLKI-----
---------------KNYFQVSFLFRMIFSCLVDADRLDTEKFCQIAENK-PLSARGQY-----PSITELKT
QFDQSLNAF-------------QQNDIDINQKRSAILSTVRHNA--KTFNPSSSGLFSLTVPTGGGKTLTSM
AFALDHAETYQKRRIIYVIPFTSIIEQNAEVF-----------------RKQFGENHQHA--IIEHHSAFND
VD----------IKNPDSRTKLKMAMENWDAPIIVTTAVQFMESLFSNRPSECRKLHRIANSVIILDEAQTL
PLDLLRPCMAAIDELAKNYACSIVLCTATQPAL----LEKEDGFK---------GGF----QNVRELAQSDS
INPEQLYKDF-QRVSVSH-I--GELDD----AAIIQCL--RNEEQILCIVNTRRQAQLLYQG----------
IVDLE-----GSFHLSTYMCAVHRKAVLKIIREAL--D-----AGKP---CRVVSTSLIEAGVDVDFPLVMR
SDAGLDSIAQAAGRCNREGKNKKEDSHVWIFTAKD--H-KP-PNE--LETYASKMKEVMDIAEFKDDL----
---LGISAIKEYFSRVY----WQKET-GQNS----ELD--------K-----------HNI-------LKTL
QD--S------NIKNLPFDWMAQ---KFKMI-STTMKTVIVPY------DDVAKDCIEQLKN----LPEWES
VGKLARNLQVYTISVPQHLTGE-LIKIKALQY------VQPERFGDQFLVLESG-------N-MYDKNIGF
>tr|A0A1Y4HP34|A0A1Y4HP34_9ACTN/16-778 Uncharacterized protein OS=Collinsella sp. An2 OX=1965585 GN=B5F33_04140 PE=4 SV=1
WYAHSPSE-ER-------PGYW-----QN---LDSHLLNVAALAKGFSDKFG--FSVWGDVLGRLHDIGKAT
AAFQERLA------------GSRQH----VDH---ATPGALFAYASFQTPQ---DKIAAAILAYAIAGHHGG
MPNG--LAKGPFAQRV----PLTNRFKA------YDDSDLAWVNARLGELGIALPGVKDLEPLPFLCRMPQS
AQDDK------AFRDSAVFSLSLLCRMLYSCLVDADYLDTEAFMMPSRANVRASSRP-------LALRELSD
RLDHYLDAL-----------TASASPSAVNDARASILGSCRVAA--D-NKP---GVFTLTVPTGGGKTLSSL
SFALRHAIAHGMERVIYAIPYTSIVEQTAQVF-----------------RNVLGAEN-----VLEHHSNYDF
EE------------DAERGEISRLLTQNWNAPIVVTTNVQLFESLFSNRPGKCRKVHNIARSVVVLDEAQTL
PDGLLKPTLAMIEDLCLDFGASVVLCTATQPAL---------------------AGLWPFGTEAREIVT---
-NRNGFDRAFGGRTQFVW-E--TEIDE----QDLASRL--VDERAVLCIVGTKSKAKSIYENVKSLIGVAED
QAECNGCCDFGLFHLSANMTPLHRSRVLEKIRARL--T-----AGER---CIVVSTQLIEAGVDIDFPSVYR
ELAGIDSLFQAAGRCNREGT--RAQGEVHVFELLSDRE-KP-TPHTWLERMKSIARALIE--RNGGV-----
---IDDELVPAFFRQRY----ETD-----GD----GLD--------G-----------KGI-------FREL
TD--R-GLIESELKTLQLESVAN---EYRII-EDDTTPVFVPW------GEDGAKMLCDLQRRIEHG---VE
PAALVMRMQRSSVSVRGYLYEK-LKEAGAI----------DDESYQPLAVLQPD----VGGNRYYSDEVGL
>tr|A0A1M2Z3V3|A0A1M2Z3V3_9RHIZ/3-735 CRISPR-associated protein Cas3 OS=Rhizobium sp. 63-7 OX=1895820 GN=BGN83_01600 PE=4 SV=1
YYAHSGRA-DD-------KGDW-----QG---LKEHLEQVAALAGQMAEALG--LGKAAMLAGLFHDLGKYT
LDFQKRLT------------GAEIS----VDH---STAGAWHILQAVQGE----DRFIAELIAYAILGHHAG
LPDKRGSEA-----------ALTERIAG------FKSALLDK--AWPTEISADL-----SGLMPGFSWA---
-----------NTRERLAFQMAFCGRMLFSCLVDADFKDTEAYYSALEG--RYPDRVWQPL--QTLLPQFIA
GFERSMADK-------------KSKPSDLNTLRSEILAHVREKT--G-EKP---GLFTLTVPTGGGKTLASL
AFALDHAQAHGHSRIIYAIPFTSIIDQTAAIF-----------------RDVLGDEH-----VLEHHSAIDE
EK-------FVSMQGRESRDKLKLAMEDWAAPVVVTTNVQLFESLFAARTSRARKLHNIAGSIIILDEAQTI
PRHLLSPAVRALDELARNYKCTIVLCTATQPAL------DERNFP-----PMHPAGLP---LEGRELAP---
-DPERLARQL-RRVTIQR-A--GEMSN----ADLIGAL--EETPQGLVIVNSRKHALELFREA--------E
AAGLT-----GLVHLTTRQHAAHRREILADIRQRL--R-----GEAP---CRVIATSLVEAGVDVDFPKVWR
AEAGLDSIAQAAGRCNREGRQPVEASIVTVFSAPD--Y-PP-PSE--IKGLIADTARMVD--KHE-DL----
---LSPRAIAAYFEEVY----WRV---G-IK----GLD--------G-----------KSI-------LDRF
RM--DK-----TGTDFAYRSVAA---DFRMI-ESQMVSVIIAR------DEVAKKAVDELGI----PE--IP
SGALATKLQTYVVQIPLKAREL-MRENGHVAF------IHPKIRGDQFAVLQTA-------S-MYEEEIGL
>tr|A0A4R4AGQ3|A0A4R4AGQ3_MARGR/9-735 CRISPR-associated Cas3 family helicase OS=Marichromatium gracile OX=1048 GN=EDC29_102347 PE=4 SV=1
CFAHSTDS-GR-------AADW-----QP---LAEHLHNVARLAAARAAPFG--CETLAETAGLLHDLGKYT
DDFQRRLA------------GEAVR----VDH---ATRGAQLALERYPG--------LGQLLAYAIAGHHGG
LANG--AES---GERT----ALRERLAR------DGLPPLLD--VWRQEIA--LPEA--LERPPLIV-----
-----------HSRERGMFQLSFLVRMLFSCLVDADYLDTEAFYDRVERP-PGVRRETLRAAPSPSLAALCD
RLDAHLQGF--------------AASRPVDRLRGDILDHVRGQA--T-LPP---GLFSLTVPTGGGKTLTSL
AFALDHALVHGLRRVICVIPFTSIVEQTAASF-----------------RAALGELGETA--VLEHHSAFVP
SV---------ADEGAKASDKLRLAMENWDAPIVVTTAVQFFESLFAARPSQCRKLHNVAGSVVILDEAQTL
PLKLLRPTVAAIDELARNYGCTLVLCTATQPAL------NAPAFR---------GGL----DKVRELAP---
-DPPALYRRL-ERVRIGH-L--GEVDD----AALVARL--QGHEQVLCIVNNRRHARALYQA----------
IAEQP-----GACHLSTLMCARHRSAVLAEVRARL--D-----RGAP---CRLVATSLIEAGVDVSFPVVYR
AEAGLDSIAQAAGRCNRHGEDRAEDSPVWVFAPAGEDW-AP-PPE--LKQFAQAGREVLR--RHSEAP----
---LAPAAIDAYFQLLY----WQQ---G-DE----ALD--------R-----------HDL-------LGLL
RC--S------RPDGLPLETLAS---RYRLI-ETTQVAVIVPY------DEAARGALAALEH----V---PR
CGGVARRLQPYLVQVPGRALAE-LRAAGAVQP------VAEARWGEQFLALMNP-------D-LYSPDFGL
>tr|A0A380TSH1|A0A380TSH1_ACTLI/9-747 CRISPR-associated helicase Cas3 OS=Actinobacillus lignieresii OX=720 GN=NCTC4191_00495 PE=4 SV=1
FYAHSGKL-SD-------HSDW-----QT---LLSHANNVGLLAAEFAAPFA--SQEIAHCTGLLHDLGKYS
VRYQKRLH------------GG-ER----VNH---STAGAKIAVERWGP--------LGKMMAFCIAGHHAG
LANG--SGE---GKNR-S--TLTQRLQEQFGHGHKYLPLLDP--IWQQELN--LPEK--LPLPPLK------
-----------PSKYDPFFSYAFFIRMLYSCLVDADFLDTEAFYANLEK--RPLERGNY-----PNLTALHQ
QFNQFIAQFRERIATQTPDTQEAQRKAEVNRLRSEILDYAVSQA--K-QET---GLFSLTVPTGGGKTFTSM
AFALEHAKQHGLHRIIYVIPFTSIIEQNAAEF-----------------RKAFGELGAEA--VLEHHSTFDH
DN----------LSDKSSRDKLKLASENWDAPIVVTTAVQFFESLFADRSSRCRKLHNIAGSVIILDEAQML
PLNLLRPIMAAIDELARNYQCSVVLCTATQPAI-----HQANGFY---------KGF----ENVREIAP---
-NPARLFEKL-KRTTVKH-I--GIQTD----VELQSKL--ADNSQMLIIVNNRRHARSLYDS----------
AKHLD-----GTYHLTTLMCAKHRSQTLEEIRLRL--K-----QNLP---CRVIATSLIEAGVDVDFPLVMR
AEAGLDSVAQAAGRCNREGKQLAETSYVWVFQPEE-QW-KA-PLE--LGLLSGCMRSTVQ--VHADEL----
---LTPQAINHYFQAVY----EAK-----GK----ELD--------K-----------PNI-------LKAC
HD--A-----GQSLNFPFQNIAE---DFRMI-TSHLIPVIIPF------DQEAENLIDRLRY----A---DQ
VGGILRKLQAYTIQIPEKALAE-LYNAGRVEA------INEPNFGKQFYCLIGI-------D-LYDEVAGL
>tr|A0A2Y9B9T6|A0A2Y9B9T6_9FIRM/7-754 CRISPR-associated Cas3 family helicase OS=Faecalicatena orotica OX=1544 GN=A8806_102288 PE=4 SV=1
LLALYNQDKEEFKHKLSGPEMWNMALARRNQLLKTHLSNVSKLARKFGSRFG--MEEILWVAGYLHDYGKGS
PQWQEYLI--------------KRLMYEDVSMVPHSIYGAKYCFTKANF-----FQHIAEMLGNIIMSHHGS
LYDN--ISP---DGET----VLKDVLTNETE---VKIPAEFS-------IDFELLNNEFMNIINS-------
-----------DKQADKPFYMSMLIKLAYSCLVDADRLDALGVENSELY--SPAA---------PEWDVLIS
NLEKKISKL------------QAKEQSEMSILRKRGSEDCKTAG--L-RDI---GIYKLEVATGGGKTFASL
RFALEHARHHKLDRIIYVIPYLSIISQTAKEI-----------------RNALNLDDNM---VLEHHSGFLP
DN----------------EQYYKLHTDRWDATIIITTQVQFLESIFSAKGSDLRKFHNMGNSVLIFDEAQSI
PIKVIHLFNSAINFINKICKSTVLLCTATQPPF------ESALRK---------LRF----SNHPSLTK---
------YREPPKRYEIRNQLKTGGYTY----SELAEFVLKKAQKSTLVILNTKKAVKLLYKEL--------H
NKGIP------VFHLSNNMCSTHLNNEIEKITKRL--E-----KDMP---VLCISSQLIEAGVDISFDCVIR
DLAGLDSIFQAAGRCNRHGK--PEIGNVYVINIRDENL-SK-LPD--IKKGAAITRRLFN--EDKIYD----
--------INLYYNHYF----YTQ-----QS----EMD------------YNIDGGSVYDLLSCNKQGQGAY
LKRKDKQGMKPPGIWSAIRSAAD---EFYVI-DKGRMDIIVHY-------GESTELLEKYNI----ATDIVD
KRNILKKLGGFSISLYQYQLDA-LKRNGAVDD----------QNYKGLTVLKND---------FYDKIIGL
>tr|A0A1T4L5L3|A0A1T4L5L3_9RHIZ/2-764 CRISPR-associated helicase, Cas3 family OS=Consotaella salsifontis OX=1365950 GN=SAMN05428963_10160 PE=4 SV=1
FYAHSNKS-DD-------RSDW-----EP---LADHLNRVADLARRFGAPLK--IAAAARLAGLLHDIGKYH
PAFQARLN------------GARDR----VDH---STAGAAAIMRVARTSD---ERAIAWLIAQGIAGHHAG
LPDR--------NGADLA--NLCARLDG------FDFGRLGG--DWSDFVPDTLQEI------GFGLDWR--
-----------SPKHEAANRLAMLGRMIFSCLVDADFLETERYYVERGE--RAKDRDWPSL--AECLPSFQA
GFQAKIDGF-------------GEPKSEMARHRAAILSTVRERA--VSLEP---GLFTLDVPTGGGKTLASL
GFALDHAATWGHRRIIYGIPFTSIVDQTAEVF-----------------REVLGAEA-----ILEHHSAVED
EQ--PERDVKKADTDEFGRDKMRLAMENWAAPVVITTHVQLFESLFAARTSRARKLHNIAGSVIVLDEAQVL
PKPLLAPTVRAIDALARDWGCSIVLCTATQPAF------DARRFDTHKLGRRHPLALD---LEGRELAP---
-DPDTLHRTF-VRNRLIQ-A--GEMDD----DALVSAL--KDEPQALVIVNSRAHALALFRLA--------Q
AEKLD-----GLVHLTTRQCAAHRKAILKDVRARL--KPADEGGGQP---CRLIATSLIEAGVDVDFPKAWR
AEAGLDQIVQAAGRVNREMRRPPETSTVTVFRPKE--S-KP-PRE--IKALAEAMARTVQ--QHD-DL----
---FSREAIQTYFDEVY----WQT---G-VE----GLD--------AAPLRDLRDGETRGI-------LTQM
SY--T----KVQGVDIAYRTIAE---RYRMI-ETGMLPVIVVL------DDVAKGAVDKLSL----AN--IP
SGALARALQPYIVQVPPRARAL-LVANQHVAF------AAQDIRGDQFAVLKTP-------S-LYDEKVGL
