RID: 0U7MNHGY016 Job Title:J3F2B0:RecName: Full=CRISPR-associated endonuclease... Program: BLASTP Query: unnamed protein product ID: lcl|Query_11077403(amino acid) Length: 1101 Database: swissprot Non-redundant UniProtKB/SwissProt sequences Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=CRISPR-associated endonuclease Cas9; AltName:... Actinomyces ... NA 1115803 2270 2270 100% 0.0 100.00 1101 J3F2B0.1 RecName: Full=CRISPR-associated endonuclease Cas9; AltName:... Corynebacter... NA 257309 877 877 99% 0.0 44.02 1084 Q6NKI3.1 RecName: Full=CRISPR-associated endonuclease Cas9 [Pasteurella... Pasteurella ... NA 272843 70.9 70.9 44% 5e-11 23.68 1056 Q9CLT2.1 RecName: Full=CRISPR-associated endonuclease Cas9 [Neisseria... Neisseria me... NA 122587 62.0 62.0 70% 2e-08 22.94 1082 A1IQ68.1 RecName: Full=CRISPR-associated endonuclease Cas9 [Neisseria... Neisseria me... NA 604162 61.6 61.6 30% 4e-08 25.14 1082 C9X1G5.1 RecName: Full=CRISPR-associated endonuclease Cas9; AltName:... Staphylococc... NA 1280 58.2 58.2 31% 4e-07 22.60 1053 J7RUA5.1 RecName: Full=CRISPR-associated endonuclease Cas9 [Campylobact... Campylobacte... NA 192222 53.5 53.5 29% 1e-05 22.61 984 Q0P897.1 RecName: Full=CRISPR-associated endonuclease Cas9 1; AltName:... Streptococcu... NA 322159 44.7 44.7 25% 0.006 27.60 1121 Q03LF7.1 Alignments: >RecName: Full=CRISPR-associated endonuclease Cas9; AltName: Full=AnaCas9 [Actinomyces naeslundii str. Howell 279] Sequence ID: J3F2B0.1 Length: 1101 Range 1: 1 to 1101 Score:2270 bits(5882), Expect:0.0, Method:Compositional matrix adjust., Identities:1101/1101(100%), Positives:1101/1101(100%), Gaps:0/1101(0%) Query 1 MWYASLMSAHHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGVGKEGKKDHD 60 MWYASLMSAHHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGVGKEGKKDHD Sbjct 1 MWYASLMSAHHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGVGKEGKKDHD 60 Query 61 TRKKLSGIARRARRLLHHRRTQLQQLDEVLRDLGFPIPTPGEFLDLNEQTDPYRVWRVRA 120 TRKKLSGIARRARRLLHHRRTQLQQLDEVLRDLGFPIPTPGEFLDLNEQTDPYRVWRVRA Sbjct 61 TRKKLSGIARRARRLLHHRRTQLQQLDEVLRDLGFPIPTPGEFLDLNEQTDPYRVWRVRA 120 Query 121 RLVEEKLPEELRGPAISMAVRHIARHRGWRNPYSKVESLLSPAEESPFMKALRERILATT 180 RLVEEKLPEELRGPAISMAVRHIARHRGWRNPYSKVESLLSPAEESPFMKALRERILATT Sbjct 121 RLVEEKLPEELRGPAISMAVRHIARHRGWRNPYSKVESLLSPAEESPFMKALRERILATT 180 Query 181 GEVLDDGITPGQAMAQVALTHNISMRGPEGILGKLHQSDNANEIRKICARQGVSPDVCKQ 240 GEVLDDGITPGQAMAQVALTHNISMRGPEGILGKLHQSDNANEIRKICARQGVSPDVCKQ Sbjct 181 GEVLDDGITPGQAMAQVALTHNISMRGPEGILGKLHQSDNANEIRKICARQGVSPDVCKQ 240 Query 241 LLRAVFKADSPRGSAVSRVAPDPLPGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGE 300 LLRAVFKADSPRGSAVSRVAPDPLPGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGE Sbjct 241 LLRAVFKADSPRGSAVSRVAPDPLPGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGE 300 Query 301 NRPLTADERRHVVTFLTEDSQADLTWVDVAEKLGVHRRDLRGTAVHTDDGERSAARPPID 360 NRPLTADERRHVVTFLTEDSQADLTWVDVAEKLGVHRRDLRGTAVHTDDGERSAARPPID Sbjct 301 NRPLTADERRHVVTFLTEDSQADLTWVDVAEKLGVHRRDLRGTAVHTDDGERSAARPPID 360 Query 361 ATDRIMRQTKISSLKTWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPEEDQAKLDSL 420 ATDRIMRQTKISSLKTWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPEEDQAKLDSL Sbjct 361 ATDRIMRQTKISSLKTWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPEEDQAKLDSL 420 Query 421 HLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEAINAPVGNPSVDR 480 HLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEAINAPVGNPSVDR Sbjct 421 HLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEAINAPVGNPSVDR 480 Query 481 TLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMADERDKANRRRYNDNQEAMKKIQR 540 TLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMADERDKANRRRYNDNQEAMKKIQR Sbjct 481 TLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMADERDKANRRRYNDNQEAMKKIQR 540 Query 541 DYGKEGYISRGDIVRLDALELQGCACLYCGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVA 600 DYGKEGYISRGDIVRLDALELQGCACLYCGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVA Sbjct 541 DYGKEGYISRGDIVRLDALELQGCACLYCGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVA 600 Query 601 VCERCNRSKSNTPFAVWAQKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIAR 660 VCERCNRSKSNTPFAVWAQKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIAR Sbjct 601 VCERCNRSKSNTPFAVWAQKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIAR 660 Query 661 LRRTQEDPEIDERSMESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSRIN 720 LRRTQEDPEIDERSMESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSRIN Sbjct 661 LRRTQEDPEIDERSMESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSRIN 720 Query 721 LIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGST 780 LIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGST Sbjct 721 LIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGST 780 Query 781 VGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRLRLSDGNAHTVNPSKLVSHRLGD 840 VGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRLRLSDGNAHTVNPSKLVSHRLGD Sbjct 781 VGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRLRLSDGNAHTVNPSKLVSHRLGD 840 Query 841 GLTVQQIDRACTPALWCALTREKDFDEKNGLPAREDRAIRVHGHEIKSSDYIQVFSKRKK 900 GLTVQQIDRACTPALWCALTREKDFDEKNGLPAREDRAIRVHGHEIKSSDYIQVFSKRKK Sbjct 841 GLTVQQIDRACTPALWCALTREKDFDEKNGLPAREDRAIRVHGHEIKSSDYIQVFSKRKK 900 Query 901 TDSDRDETPFGAIAVRGGFVEIGPSIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLF 960 TDSDRDETPFGAIAVRGGFVEIGPSIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLF Sbjct 901 TDSDRDETPFGAIAVRGGFVEIGPSIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLF 960 Query 961 SAVIPPQSISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDFPN 1020 SAVIPPQSISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDFPN Sbjct 961 SAVIPPQSISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDFPN 1020 Query 1021 TTRWRICGYDTNSKLTLKPIVLAAEGLENPSSAVNEIVELKGWRVAINVLTKVHPTVVRR 1080 TTRWRICGYDTNSKLTLKPIVLAAEGLENPSSAVNEIVELKGWRVAINVLTKVHPTVVRR Sbjct 1021 TTRWRICGYDTNSKLTLKPIVLAAEGLENPSSAVNEIVELKGWRVAINVLTKVHPTVVRR 1080 Query 1081 DALGRPRYSSRSNLPTSWTIE 1101 DALGRPRYSSRSNLPTSWTIE Sbjct 1081 DALGRPRYSSRSNLPTSWTIE 1101 >RecName: Full=CRISPR-associated endonuclease Cas9; AltName: Full=SaCas9 [Corynebacterium diphtheriae NCTC 13129] Sequence ID: Q6NKI3.1 Length: 1084 Range 1: 5 to 1084 Score:877 bits(2267), Expect:0.0, Method:Compositional matrix adjust., Identities:486/1104(44%), Positives:679/1104(61%), Gaps:40/1104(3%) Query 14 VGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGVGKEGKKDHDTRKKLSGIARRAR 73 VGIDVGT SVGLA + VDD G PI+ LS +SHIHDSG+ + K TR SGIARR R Sbjct 5 VGIDVGTFSVGLAAIEVDDAGMPIKTLSLVSHIHDSGLDPDEIKSAVTRLASSGIARRTR 64 Query 74 RLLHHRRTQLQQLDEVLRDLGFPIPTPGEFLDLNEQTDPYRVWRVRARLVEEKLPEEL-R 132 RL +R +LQQLD+ ++ G+P+ ++L + +DP W+VRA L + +E R Sbjct 65 RLYRRKRRRLQQLDKFIQRQGWPV------IELEDYSDPLYPWKVRAELAASYIADEKER 118 Query 133 GPAISMAVRHIARHRGWRNPYSKVESLLSPAEESPFMKALRERILATTGEVLDDGITPGQ 192 G +S+A+RHIARHRGWRNPY+KV SL P S KA+RE I +G+ + + T GQ Sbjct 119 GEKLSVALRHIARHRGWRNPYAKVSSLYLPDGPSDAFKAIREEIKRASGQPVPETATVGQ 178 Query 193 AMAQVALTHNISMRGPEGIL-GKLHQSDNANEIRKICARQGVSPDVCKQLLRAVFKADSP 251 M + + +RG G+L +L QSD A EI++IC Q + ++ ++++ VF A+SP Sbjct 179 -MVTLCELGTLKLRGEGGVLSARLQQSDYAREIQEICRMQEIGQELYRKIIDVVFAAESP 237 Query 252 RGSAVSRVAPDPL-PGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGENRPLTADERR 310 +GSA SRV DPL PG+ RA K FQR+RI +++ NLR+ GE R L+ +E+ Sbjct 238 KGSASSRVGKDPLQPGKN---RALKASDAFQRYRIAALIGNLRV-RVDGEKRILSVEEKN 293 Query 311 HVVTFLTEDS-QADLTWVDVAEKLGVHRRDLRGTAVHTDDGERSAARPPIDATDRIMRQT 369 V L + + + WV +AE LG+ R L GTA TDDGER+ ARPP T+R + + Sbjct 294 LVFDHLVNLTPKKEPEWVTIAEILGIDRGQLIGTATMTDDGERAGARPPTHDTNRSIVNS 353 Query 370 KISSLKTWWEEADSEQRGAMIRYL-------YEDPTDSECAEIIAELPEEDQAKLDSLHL 422 +I+ L WW+ A + ++ AM++ L ++ P ++ A+L ++ AKLDSLHL Sbjct 354 RIAPLVDWWKTASALEQHAMVKALSNAEVDDFDSPEGAKVQAFFADLDDDVHAKLDSLHL 413 Query 423 PAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEAINAPVGNPSVDRTL 482 P GRAAYS ++L L+ ML+ DL+ AR + FG++ SW PP I PVGNP+VDR L Sbjct 414 PVGRAAYSEDTLVRLTRRMLSDGVDLYTARLQEFGIEPSWTPPTPRIGEPVGNPAVDRVL 473 Query 483 KIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMADERDKANRRRYNDNQEAMKKIQRDY 542 K V R+L + WG PE + +EHVR+GF +E+ A E D RRR N + +++Q Sbjct 474 KTVSRWLESATKTWGAPERVIIEHVREGFVTEKRAREMDGDMRRRAARNAKLFQEMQEKL 533 Query 543 GKEGYISRGDIVRLDALELQGCACLYCGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVAVC 602 +G SR D+ R +++ Q C C YCG+ I + ++DHIVP+AG GS N R NLVAVC Sbjct 534 NVQGKPSRADLWRYQSVQRQNCQCAYCGSPITFSNSEMDHIVPRAGQGSTNTRENLVAVC 593 Query 603 ERCNRSKSNTPFAVWAQKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLR 662 RCN+SK NTPFA+WA+ I V VKEA+ R R W T S D + K V+ R + Sbjct 594 HRCNQSKGNTPFAIWAKNTSIEGVSVKEAVERTRHWVTDT-GMRSTDFKKFTKAVVERFQ 652 Query 663 RTQEDPEIDERSMESVAWMANELHHRIAAAYPE--TTVMVYRGSITAAARKAAGIDSRIN 720 R D EID RSMESVAWMANEL R+A + TTV VYRGS+TA AR+A+GI ++ Sbjct 653 RATMDEEIDARSMESVAWMANELRSRVAQHFASHGTTVRVYRGSLTAEARRASGISGKLK 712 Query 721 LIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGST 780 G K R+DRRHHA+DA+V+A VA+TLA RS+L+ Q + W+++TG Sbjct 713 FFDGVG-KSRLDRRHHAIDAAVIAFTSDYVAETLAVRSNLKQSQAHRQEAPQWREFTGKD 771 Query 781 VGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRLRLSDGNAHTVNPSKLVSHRLGD 840 R + +W M L+ L E L +D+V V N+RLRL +G+AH KL +L Sbjct 772 AEHRAAWRVWCQKMEKLSALLTEDLRDDRVVVMSNVRLRLGNGSAHKETIGKLSKVKLSS 831 Query 841 GLTVQQIDRACTPALWCALTREKDFDEKNGLPAREDRAIRVHGHEIKSSDYIQVFSKRKK 900 L+V ID+A + ALWCALTRE FD K GLPA +R IRV+G + + D I +F Sbjct 832 QLSVSDIDKASSEALWCALTREPGFDPKEGLPANPERHIRVNGTHVYAGDNIGLFP---- 887 Query 901 TDSDRDETPFGAIAVRGGFVEIGPSIHHARIYRV-EGKKPVYAMLRVFTHDLLSQRHGDL 959 G+IA+RGG+ E+G S HHAR+Y++ GKKP +AMLRV+T DLL R+ DL Sbjct 888 -------VSAGSIALRGGYAELGSSFHHARVYKITSGKKPAFAMLRVYTIDLLPYRNQDL 940 Query 960 FSAVIPPQSISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDFP 1019 FS + PQ++SMR AE KLR A+ TGNA YLGW+VV DEL ++ + + Sbjct 941 FSVELKPQTMSMRQAEKKLRDALATGNAEYLGWLVVDDELVVDTSKIATDQVKAVEAELG 1000 Query 1020 NTTRWRICGYDTNSKLTLKPIVLAAEGLENPSSA-VNEIVELKGWRVAIN-VLTKVHPTV 1077 RWR+ G+ + SKL L+P+ ++ EG++ S+ +++I++ GW A+N + + + TV Sbjct 1001 TIRRWRVDGFFSPSKLRLRPLQMSKEGIKKESAPELSKIIDRPGWLPAVNKLFSDGNVTV 1060 Query 1078 VRRDALGRPRYSSRSNLPTSWTIE 1101 VRRD+LGR R S ++LP +W ++ Sbjct 1061 VRRDSLGRVRLESTAHLPVTWKVQ 1084 >RecName: Full=CRISPR-associated endonuclease Cas9 [Pasteurella multocida subsp. multocida str. Pm70] Sequence ID: Q9CLT2.1 Length: 1056 Range 1: 258 to 733 Score:70.9 bits(172), Expect:5e-11, Method:Compositional matrix adjust., Identities:121/511(24%), Positives:213/511(41%), Gaps:63/511(12%) Query 272 RAPKCDPEFQRFRIISIVANLRISETKGENRPLTADERRHVVTFLTEDSQADLTWVDVAE 331 +A K +RF ++ + NLRI E G R L +ER+ ++ E S+ LT+ V + Sbjct 258 KAAKHTYSAERFVWLTKLNNLRILED-GAERALNEEERQLLINHPYEKSK--LTYAQVRK 314 Query 332 KLGVHRRDLRGTAVHTDDGERSAARPPIDATDRIMRQTKISSLKTWWEEA----DSEQRG 387 LG+ + + ++ + SA + A I + + LK W++ D Sbjct 315 LLGLSEQAIFKHLRYSKENAESATFMELKAWHAIRKALENQGLKDTWQDLAKKPDLLDEI 374 Query 388 AMIRYLYEDPTDSECAEIIA-ELPEEDQAKLDSLHLPAGRAAYSRESLTALSD--HMLAT 444 LY+ TD + + + ++P + +++L + + SL +L ++ Sbjct 375 GTAFSLYK--TDEDIQQYLTNKVP---NSVINALLVSLNFDKFIELSLKSLRKILPLMEQ 429 Query 445 TDDLHEARKRLFG-----VDDSWAPPAEAINAP-VGNPSVDRTLKIVGRYLSAVESMWGT 498 +A + ++G + + AI A + NP V RTL + ++A+ +G+ Sbjct 430 GKRYDQACREIYGHHYGEANQKTSQLLPAIPAQEIRNPVVLRTLSQARKVINAIIRQYGS 489 Query 499 PEVIHVEHVRD---GFTSERMADERDKANRRRYNDNQEAMKKIQRDYGKEGYISRGDIVR 555 P +H+E R+ F R ++ + NR + + K++ D+ E DI++ Sbjct 490 PARVHIETGRELGKSFKERREIQKQQEDNRTKRESAVQKFKELFSDFSSEP--KSKDILK 547 Query 556 LDALELQGCACLYCGTTIGYH------TCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSK 609 E Q CLY G I H ++DH +P + ++ N V V N++K Sbjct 548 FRLYEQQHGKCLYSGKEINIHRLNEKGYVEIDHALPFSRTWDDS-FNNKVLVLASENQNK 606 Query 610 SN-TPFAVWAQKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLRRTQEDP 668 N TP+ W Q I K + V G S+ RL +VI +D Sbjct 607 GNQTPYE-WLQ-GKINSERWKNFVALVLG-----SQCSAAKKQRLLTQVI-------DDN 652 Query 669 EIDERSMESVAWMANELHHRIA-----AAYPETTVMVYRGSITAAARKAAGIDSRINLIG 723 + +R++ ++A L + I + V G ITA R SR LI Sbjct 653 KFIDRNLNDTRYIARFLSNYIQENLLLVGKNKKNVFTPNGQITALLR------SRWGLI- 705 Query 724 EKGRKDRIDRRHHAVDASVVALMEASVAKTL 754 K R++ + RHHA+DA VVA S+ + + Sbjct 706 -KAREN--NNRHHALDAIVVACATPSMQQKI 733 >RecName: Full=CRISPR-associated endonuclease Cas9 [Neisseria meningitidis Z2491] Sequence ID: A1IQ68.1 Length: 1082 Range 1: 13 to 772 Score:62.0 bits(149), Expect:2e-08, Method:Compositional matrix adjust., Identities:189/824(23%), Positives:312/824(37%), Gaps:114/824(13%) Query 14 VGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGVGKEGKKDHDTRKKLSGIARRAR 73 +G+D+G SVG A + +D+ PI L+ + + E K D+ AR Sbjct 13 LGLDIGIASVGWAMVEIDEDENPICLIDLGVRVFERA---EVPKTGDS-------LAMAR 62 Query 74 RLLHHRRTQLQQLDEVLRDLGFPIPTPG--EFLDLNE----QTDPYRVWRVRARLVEEKL 127 RL R ++ L + G + D +E ++ P W++RA ++ KL Sbjct 63 RLARSVRRLTRRRAHRLLRARRLLKREGVLQAADFDENGLIKSLPNTPWQLRAAALDRKL 122 Query 128 -PEELRGPAISMAVRHIARHRGWRNPYSKVESLLSPAEESPFMKALRERILA-TTGEVLD 185 P E S + H+ +HRG+ + K E + E +K + + A TG Sbjct 123 TPLEW-----SAVLLHLIKHRGYLSQ-RKNEGETADKELGALLKGVADNAHALQTG---- 172 Query 186 DGITPGQAMAQVALTHNISMRGPEGILG-KLHQSDNANEIRKICARQGV--SPDVCKQLL 242 D TP + + +R G + D E+ + +Q +P V L Sbjct 173 DFRTPAELALNKFEKESGHIRNQRGDYSHTFSRKDLQAELILLFEKQKEFGNPHVSGGLK 232 Query 243 RAVFKADSPRGSAVSRVAPDPLPGQGSFR----RAPKCDPEFQRFRIISIVANLRISETK 298 + + A+S A + G +F +A K +RF ++ + NLRI E + Sbjct 233 EGIETLLMTQRPALSGDAVQKMLGHCTFEPAEPKAAKNTYTAERFIWLTKLNNLRILE-Q 291 Query 299 GENRPLTADERRHVVTFLTEDS-QADLTWVDVAEKLGVHRRDLRGTAVHTDDGERSAARP 357 G RPLT ER T + E ++ LT+ + LG+ + D ++ Sbjct 292 GSERPLTDTER---ATLMDEPYRKSKLTYAQARKLLGLEDTAFFKGLRYGKDNAEASTLM 348 Query 358 PIDATDRIMRQTKISSLK------TWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPE 411 + A I R + LK E E A + ++ + I PE Sbjct 349 EMKAYHAISRALEKEGLKDKKSPLNLSPELQDEIGTAFSLFKTDEDITGRLKDRIQ--PE 406 Query 412 EDQAKLDSLHLPAGRAAYSRESLTALSD--HMLATTDDLHEARKRLFGVDDSWAPPAEAI 469 +A L + + + SL AL ++ EA ++G E I Sbjct 407 ILEALLKHISFDK----FVQISLKALRRIVPLMEQGKRYDEACAEIYGDHYGKKNTEEKI 462 Query 470 NAP------VGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRD---GFTSERMADER 520 P + NP V R L + ++ V +G+P IH+E R+ F + ++R Sbjct 463 YLPPIPADEIRNPVVLRALSQARKVINGVVRRYGSPARIHIETAREVGKSFKDRKEIEKR 522 Query 521 DKANRRRYNDNQEAMKKIQRDYGKE--GYISRGDIVRLDALELQGCACLYCGTTI----- 573 + NR+ D ++A K R+Y G DI++L E Q CLY G I Sbjct 523 QEENRK---DREKAAAKF-REYFPNFVGEPKSKDILKLRLYEQQHGKCLYSGKEINLGRL 578 Query 574 ---GYHTCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSN-TPFAVWAQKCGIPHVGVK 629 GY ++DH +P + ++ N V V N++K N TP+ + K Sbjct 579 NEKGY--VEIDHALPFSRTWDDS-FNNKVLVLGSENQNKGNQTPYEYFNGK--------- 626 Query 630 EAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLRRTQEDPEIDERSMESVAWMANELHHRI 689 R W++ + R KK+ I L++ ED ER++ ++ L + Sbjct 627 ---DNSREWQEFKARVETSRFPRSKKQRIL-LQKFDEDG-FKERNLNDTRYVNRFLCQFV 681 Query 690 A-----AAYPETTVMVYRGSITAAARKAAGIDSRINLIGEKGRKDRIDR-RHHAVDASVV 743 A + V G IT R G+ RK R + RHHA+DA VV Sbjct 682 ADRMRLTGKGKKRVFASNGQITNLLRGFWGL-----------RKVRAENDRHHALDAVVV 730 Query 744 ALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGSTVGAREHF 787 A ++ + + + GK T + TG + + HF Sbjct 731 ACSTVAMQQKITRFVRYKEMNAFDGK--TIDKETGEVLHQKTHF 772 >RecName: Full=CRISPR-associated endonuclease Cas9 [Neisseria meningitidis 8013] Sequence ID: C9X1G5.1 Length: 1082 Range 1: 463 to 772 Score:61.6 bits(148), Expect:4e-08, Method:Compositional matrix adjust., Identities:87/346(25%), Positives:139/346(40%), Gaps:56/346(16%) Query 462 WAPPAEAINAPVGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRD---GFTSERMAD 518 + PP A + NP V R L + ++ V +G+P IH+E R+ F + + Sbjct 463 YLPPIPA--DEIRNPVVLRALSQARKVINGVVRRYGSPARIHIETAREVGKSFKDRKEIE 520 Query 519 ERDKANRRRYNDNQEAMKKIQRDYGKE--GYISRGDIVRLDALELQGCACLYCGTTI--- 573 +R + NR+ D ++A K R+Y G DI++L E Q CLY G I Sbjct 521 KRQEENRK---DREKAAAKF-REYFPNFVGEPKSKDILKLRLYEQQHGKCLYSGKEINLG 576 Query 574 -----GYHTCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSN-TPFAVWAQKCGIPHVG 627 GY ++DH +P + ++ N V V N++K N TP+ + K Sbjct 577 RLNEKGY--VEIDHALPFSRTWDDS-FNNKVLVLGSENQNKGNQTPYEYFNGK------- 626 Query 628 VKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLRRTQEDPEIDERSMESVAWMANELHH 687 R W++ + R KK+ I L++ ED ER++ ++ L Sbjct 627 -----DNSREWQEFKARVETSRFPRSKKQRIL-LQKFDEDG-FKERNLNDTRYVNRFLCQ 679 Query 688 RIA-----AAYPETTVMVYRGSITAAARKAAGIDSRINLIGEKGRKDRIDR-RHHAVDAS 741 +A + V G IT R G+ RK R + RHHA+DA Sbjct 680 FVADRMRLTGKGKKRVFASNGQITNLLRGFWGL-----------RKVRAENDRHHALDAV 728 Query 742 VVALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGSTVGAREHF 787 VVA ++ + + + GK T + TG + + HF Sbjct 729 VVACSTVAMQQKITRFVRYKEMNAFDGK--TIDKETGEVLHQKTHF 772 >RecName: Full=CRISPR-associated endonuclease Cas9; AltName: Full=SaCas9 [Staphylococcus aureus] Sequence ID: J7RUA5.1 Length: 1053 Range 1: 256 to 593 Score:58.2 bits(139), Expect:4e-07, Method:Compositional matrix adjust., Identities:80/354(23%), Positives:153/354(43%), Gaps:34/354(9%) Query 283 FRIISIVANLRISETKGENRPLTADERRHVVTFLTEDSQADLTWVDVAEKLGVHRRDLRG 342 + ++ + NL I T+ EN L E+ ++ + + + T +A+++ V+ D++G Sbjct 256 YNALNDLNNLVI--TRDENEKLEYYEKFQIIENVFKQKKKP-TLKQIAKEILVNEEDIKG 312 Query 343 TAVHTDDGERSAARPPIDATDRIMRQTKISSLKTWWEEADSEQRGAMIRYLYEDPTD--S 400 V S +P I++ K E A+ + A I +Y+ D Sbjct 313 YRV------TSTGKPEFTNLKVYHDIKDITARKEIIENAELLDQIAKILTIYQSSEDIQE 366 Query 401 ECAEIIAELPEEDQAKLDSLHLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLF---- 456 E + +EL +E+ ++ +L G S +++ + D + T D+ RL Sbjct 367 ELTNLNSELTQEEIEQISNLKGYTGTHNLSLKAINLILDELWHTNDNQIAIFNRLKLVPK 426 Query 457 GVDDSWAP--PAEAINAPVGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRDGFT-- 512 VD S P ++ + +P V R+ + ++A+ +G P I +E R+ + Sbjct 427 KVDLSQQKEIPTTLVDDFILSPVVKRSFIQSIKVINAIIKKYGLPNDIIIELAREKNSKD 486 Query 513 SERMADERDKANRRRYNDNQEAMKKIQRDYGKEGYISRGDIVRLDALELQGCACLYCGTT 572 +++M +E K NR+ E +++I R GKE ++ I ++ ++Q CLY Sbjct 487 AQKMINEMQKRNRQ----TNERIEEIIRTTGKEN--AKYLIEKIKLHDMQEGKCLYSLEA 540 Query 573 IGYH-------TCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSN-TPFAVWA 618 I ++DHI+P++ +N N V V + N K N TPF + Sbjct 541 IPLEDLLNNPFNYEVDHIIPRS-VSFDNSFNNKVLVKQEENSKKGNRTPFQYLS 593 >RecName: Full=CRISPR-associated endonuclease Cas9 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819] Sequence ID: Q0P897.1 Length: 984 Range 1: 447 to 761 Score:53.5 bits(127), Expect:1e-05, Method:Compositional matrix adjust., Identities:78/345(23%), Positives:136/345(39%), Gaps:55/345(15%) Query 473 VGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRD--GFTSERMADERDKANRRRYND 530 V NP V R +K + L+A+ +G I++E R+ S+R E+++ N+ Sbjct 447 VTNPVVLRAIKEYRKVLNALLKKYGKVHKINIELAREVGKNHSQRAKIEKEQ------NE 500 Query 531 NQEAMKKIQRDYGKEGY-ISRGDIVRLDALELQGCACLYCGTTIGYHTCQ------LDHI 583 N +A K + + K G I+ +I++L + Q C Y G I Q +DHI Sbjct 501 NYKAKKDAELECEKLGLKINSKNILKLRLFKEQKEFCAYSGEKIKISDLQDEKMLEIDHI 560 Query 584 VPQAGPGSNNRRGNLVAVCERCNRSKSN-TPFAVWAQKCGIPHVGVKEAIGRVRGWRKQT 642 P + ++ N V V + N+ K N TPF + ++ K Sbjct 561 YPYS-RSFDDSYMNKVLVFTKQNQEKLNQTPFEAFGNDSA--------KWQKIEVLAKNL 611 Query 643 PNTSSEDLTRLKKEVIARLRRTQEDPEIDERSMESVAWMANELHHRIAAAYP-------- 694 P T+ +K ++ + + +E +R++ ++A R+ Y Sbjct 612 P-------TKKQKRILDKNYKDKEQKNFKDRNLNDTRYIA-----RLVLNYTKDYLDFLP 659 Query 695 ----ETTVM--VYRGSITAAARKAAGIDSRINLIGEKGRKDRIDRRHHAVDASVVALMEA 748 E T + +GS K+ + S + KDR + HHA+DA ++A Sbjct 660 LSDDENTKLNDTQKGSKVHVEAKSGMLTSALRHTWGFSAKDRNNHLHHAIDAVIIAYANN 719 Query 749 SVAKTLAERSSLRGEQRLTGKEQTWKQYTG-STVGAREHFEMWRG 792 S+ K S + EQ E K+ + R+ FE + G Sbjct 720 SIVKAF---SDFKKEQESNSAELYAKKISELDYKNKRKFFEPFSG 761 >RecName: Full=CRISPR-associated endonuclease Cas9 1; AltName: Full=Cas9** [Streptococcus thermophilus LMD-9] Sequence ID: Q03LF7.1 Length: 1121 Range 1: 474 to 746 Score:44.7 bits(104), Expect:0.006, Method:Compositional matrix adjust., Identities:85/308(28%), Positives:122/308(39%), Gaps:64/308(20%) Query 466 AEAINAPVGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRD-GFTSERMADER-DKA 523 E I PV SV + +KIV +A +G + I +E R+ E+ A ++ KA Sbjct 474 TEEIYNPVVAKSVRQAIKIV----NAAIKEYGDFDNIVIEMARETNEDDEKKAIQKIQKA 529 Query 524 NRRRYNDNQEAMKKIQRDY-GK--------EGYISRGDIVRLDALELQGCACLYCGTTIG 574 N+ ++ AM K Y GK G+ +RL QG CLY G TI Sbjct 530 NK---DEKDAAMLKAANQYNGKAELPHSVFHGHKQLATKIRL--WHQQGERCLYTGKTIS 584 Query 575 YH-------TCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSN-TPFA-------VWAQ 619 H ++DHI+P ++ N V V N+ K TP+ W+ Sbjct 585 IHDLINNSNQFEVDHILP-LSITFDDSLANKVLVYATANQEKGQRTPYQALDSMDDAWS- 642 Query 620 KCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARL---RRTQEDPEIDERSME 676 +E VR K N E L L +E I++ ++ E +D R Sbjct 643 --------FRELKAFVRE-SKTLSNKKKEYL--LTEEDISKFDVRKKFIERNLVDTRYAS 691 Query 677 SVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSRINLIGEKGRKDRIDRRHH 736 V A + H R A +T V V RG T+ R+ GI+ K R HH Sbjct 692 RVVLNALQEHFR--AHKIDTKVSVVRGQFTSQLRRHWGIE-----------KTRDTYHHH 738 Query 737 AVDASVVA 744 AVDA ++A Sbjct 739 AVDALIIA 746