RID: 84Y2XMAY016 Job Title:CCE23001:delta(14)-sterol reductase [Methylotuvimicrobium... Program: BLASTP Database: swissprot Non-redundant UniProtKB/SwissProt sequences Query #1: delta(14)-sterol reductase [Methylotuvimicrobium alcaliphilum 20Z] Query ID: emb|CCE23001.1 Length: 427 Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14... Methylotuvim... NA 1091494 878 878 100% 0.0 100.00 427 G4SW86.1 RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14... Dictyosteliu... NA 44689 359 359 99% 1e-119 44.34 462 Q54PP1.1 RecName: Full=Delta(14)-sterol reductase erg24; AltName:... Schizosaccha... NA 284812 310 310 82% 5e-101 46.09 424 Q09195.1 RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-S... Rattus norve... Norway rat 10116 305 305 94% 2e-96 42.54 620 O08984.1 RecName: Full=Delta(14)-sterol reductase TM7SF2;... Homo sapiens human 9606 298 298 80% 2e-96 45.43 418 O76062.3 RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-S... Mus musculus house mouse 10090 303 303 94% 6e-96 41.81 626 Q3U9G9.2 RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-S... Homo sapiens human 9606 295 295 82% 5e-93 43.73 615 Q14739.2 RecName: Full=Delta(14)-sterol reductase TM7SF2;... Mus musculus house mouse 10090 288 288 80% 8e-93 43.68 418 Q71KT5.2 RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-S... Pongo abelii Sumatran ora... 9601 292 292 82% 6e-92 43.45 615 Q5R7H4.1 RecName: Full=Delta(14)-sterol reductase ERG24; AltName:... Candida albi... NA 237561 284 284 94% 9e-91 39.46 448 A0A1D8PIC7.1 RecName: Full=Delta(14)-sterol reductase TM7SF2;... Bos taurus cattle 9913 275 275 80% 2e-87 44.29 418 Q8WMV1.1 RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-S... Gallus gallus chicken 9031 279 279 94% 1e-86 39.23 637 P23913.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Xenopus laevis African claw... 8355 274 274 95% 2e-86 38.72 473 Q7ZXH1.1 RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14... Ascobolus im... NA 5191 272 272 93% 2e-86 40.05 430 P78575.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Mus musculus house mouse 10090 271 271 94% 2e-85 40.09 471 O88455.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Xenopus trop... tropical cla... 8364 271 271 95% 4e-85 38.50 473 Q6P4M0.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Danio rerio zebrafish 7955 270 270 95% 5e-85 38.64 478 Q7SXF1.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Rattus norve... Norway rat 10116 270 270 94% 8e-85 39.86 471 Q9Z2Z8.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Bos taurus cattle 9913 270 270 95% 8e-85 38.72 475 Q5E9J5.1 RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14... Arabidopsis ... thale cress 3702 266 266 84% 1e-84 40.38 369 Q9LDR4.2 RecName: Full=Delta(14)-sterol reductase ERG24; AltName:... Saccharomyce... NA 559292 267 267 85% 2e-84 37.79 438 P32462.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Homo sapiens human 9606 266 266 100% 2e-83 37.61 475 Q9UBM7.1 RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14... Neurospora c... NA 367110 265 265 81% 1e-82 39.11 490 P38670.1 RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14... Fusarium van... NA 2747968 262 262 83% 8e-82 39.02 485 Q01447.1 RecName: Full=Probable 7-dehydrocholesterol reductase;... Acanthamoeba... NA 212035 256 256 93% 1e-79 36.58 447 Q5UQI4.1 RecName: Full=Delta(14)-sterol reductase ERG24A; AltName:... Fusarium gra... NA 229533 253 253 78% 4e-78 38.46 485 I1RR90.1 RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14... Septoria lyc... tomato leaf ... 39703 236 236 78% 2e-71 38.44 512 O13597.1 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC... Arabidopsis ... thale cress 3702 228 228 94% 2e-69 33.65 432 Q9LDU6.1 RecName: Full=Delta(14)-sterol reductase ERG24B; AltName:... Fusarium gra... NA 229533 223 223 97% 1e-66 31.75 481 I1RF79.1 RecName: Full=Delta(24(24(1)))-sterol reductase erg4B; AltName... Aspergillus ... NA 330879 218 218 96% 5e-64 33.64 571 Q4WJ59.2 RecName: Full=Delta(24(24(1)))-sterol reductase; AltName:... Schizosaccha... NA 284812 213 213 96% 3e-63 32.28 453 P36209.2 RecName: Full=Delta(24(24(1)))-sterol reductase; AltName:... Fusarium gra... NA 229533 207 207 95% 7e-60 33.33 596 I1RZZ3.1 RecName: Full=Delta(24(24(1)))-sterol reductase ERG4; AltName:... Saccharomyce... NA 559292 194 194 97% 1e-55 31.00 473 P25340.2 RecName: Full=Delta(24(24(1)))-sterol reductase; AltName:... Candida albi... NA 237561 191 191 99% 7e-55 30.91 469 A0A1D8PJ25.1 RecName: Full=Lamin-B receptor; AltName: Full=dLBR [Drosophila... Drosophila m... fruit fly 7227 66.2 66.2 44% 2e-10 28.80 741 Q8MLV1.1 Alignments: >RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=MaSR1; AltName: Full=Sterol C14-reductase [Methylotuvimicrobium alcaliphilum 20Z] Sequence ID: G4SW86.1 Length: 427 Range 1: 1 to 427 Score:878 bits(2268), Expect:0.0, Method:Compositional matrix adjust., Identities:427/427(100%), Positives:427/427(100%), Gaps:0/427(0%) Query 1 MSEQESRDNAAVDAVRQKYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWR 60 MSEQESRDNAAVDAVRQKYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWR Sbjct 1 MSEQESRDNAAVDAVRQKYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWR 60 Query 61 RFWSHVAPPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFT 120 RFWSHVAPPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFT Sbjct 61 RFWSHVAPPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFT 120 Query 121 LAVVFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWERPTGRPFYD 180 LAVVFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWERPTGRPFYD Sbjct 121 LAVVFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWERPTGRPFYD 180 Query 181 YFMGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSF 240 YFMGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSF Sbjct 181 YFMGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSF 240 Query 241 YLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIA 300 YLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIA Sbjct 241 YLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIA 300 Query 301 IVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNY 360 IVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNY Sbjct 301 IVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNY 360 Query 361 FGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPW 420 FGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPW Sbjct 361 FGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPW 420 Query 421 RIVPKIY 427 RIVPKIY Sbjct 421 RIVPKIY 427 >RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14 sterol reductase; AltName: Full=Sterol C14-reductase [Dictyostelium discoideum] Sequence ID: Q54PP1.1 Length: 462 Range 1: 20 to 461 Score:359 bits(921), Expect:1e-119, Method:Compositional matrix adjust., Identities:196/442(44%), Positives:272/442(61%), Gaps:16/442(3%) Query 1 MSEQESRDNAAVDAVRQKYGFG--FSWLVLMIALPPLVYYLWICVTYYQGELVF--TSDA 56 ++E + ++ A + V FG +L LP +VY++W + + G L+ T Sbjct 20 LTEVQKKELADLQKVHPANEFGGIIGTFLLTFILPVVVYWIWASIEFNNGYLLRPETLSV 79 Query 57 AAWRRFWSHV-------APPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDY 109 + F + + A PT AA +Y +WF QA LQ PG V G LP G+RL+Y Sbjct 80 EGVKAFLAQLYHYVITYAYPTKEAAIIYFSWFGFQAFLQHVVPGRKVLGSPLPGGARLEY 139 Query 110 RMNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQ 169 +NG S+ TL V+ + G AT+L D P++TVVNI++FVF L + Sbjct 140 TLNGWASWWITLIVIPIAIYFGLFKATILIDNYAPMMTVVNIWSFVFTFLLKIHAKLKGE 199 Query 170 WERPTGRPFYDYFMGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTV 229 ER +G FYD++MG A NPRIGS DLKLFCEARPG+I W+LMN S+AAKQ E++G +++ Sbjct 200 EERMSGHFFYDFWMGFARNPRIGSFDLKLFCEARPGLILWVLMNFSIAAKQLEVYGEISL 259 Query 230 PMLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHH 289 ++LV F +Y+ DY+ HEEA+LTT DI EKFG+ML +GDL W+PFTY Q YL H Sbjct 260 SVILVCCFHFWYIADYYYHEEAILTTMDIITEKFGYMLVYGDLSWVPFTYCFQCYYLYKH 319 Query 290 THD-----LPVWGIIAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGS 344 + + + I +V+L G+ +FR N QKH FRR+P VWGKPA++I TK+G+ Sbjct 320 LVNGAPLHISIGYAIFVVSLKCFGFYLFRWVNSQKHDFRRNPEAPVWGKPAEFILTKRGT 379 Query 345 LLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCL 404 LL SG+WGI RH+NY GD++++ +WCLP F S PYF+ +YFT L LHR RD CL Sbjct 380 KLLCSGFWGICRHLNYTGDIILSWAWCLPCQFDSLAPYFYGIYFTSLDLHRCWRDHNACL 439 Query 405 AKYGEDWLQYRKKVPWRIVPKI 426 KYG+DW Y K+VP+ +P + Sbjct 440 VKYGDDWRAYCKRVPYNFIPGL 461 >RecName: Full=Delta(14)-sterol reductase erg24; AltName: Full=C-14 sterol reductase erg24; AltName: Full=Ergosterol biosynthetic protein 24; AltName: Full=Sterol C14-reductase erg24 [Schizosaccharomyces pombe 972h-] Sequence ID: Q09195.1 Length: 424 Range 1: 68 to 424 Score:310 bits(794), Expect:5e-101, Method:Compositional matrix adjust., Identities:165/358(46%), Positives:226/358(63%), Gaps:7/358(1%) Query 76 LYAAWFLGQAALQVWAPGPTVQGMKLPD-GSRLDYRMNGIFSFLFTLAVVF-GLVTMGWL 133 LY WF L G +G + D G+RL Y++NG S L VV + +G Sbjct 68 LYLLWFSTLTLLWKCTNGKWAKGTPIDDKGTRLLYKINGFNSACLILGVVCTSIYLLGAS 127 Query 134 DATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQW---ERPTGRPFYDYFMGTALNPR 190 ++D L+ +F+ V F Y GKQ +G +D+F+G +LNPR Sbjct 128 CMEFIWDNFLQLMFAAYVFSVVLCTFCYVQSFFGKQQLAKGGTSGNILFDWFIGRSLNPR 187 Query 191 IGSLDLKLFCEARPGMIFWLLMNLSMAAKQY-ELHGTVTVPMLLVVGFQSFYLIDYFIHE 249 IG+ D+K FCE RPG+I W++ +++ A QY L G +T M+LV+ F ++Y++D I+E Sbjct 188 IGNFDIKCFCELRPGLILWVVFDIAFACHQYLVLGGRITDSMVLVIIFHTWYVLDSLINE 247 Query 250 EAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGY 309 AVLTT DI + FG+ML +GDLVW+PF Y+LQA+YL H DL + +AI+ L GY Sbjct 248 SAVLTTMDITTDGFGYMLSFGDLVWVPFLYSLQARYLAFHPVDLGLVKTLAILCLQFLGY 307 Query 310 AIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALS 369 IFRGAN QK+ FR +PN K K+I+TK+G+ LLTSGWWG+ARH+NYFGD ++A + Sbjct 308 YIFRGANGQKNRFRSNPNDPKL-KHLKFIQTKRGTKLLTSGWWGMARHINYFGDWIMAWA 366 Query 370 WCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 WCLPA FGSPIPYF++ YF +LL+HR RDD C KYGEDW +Y K V +RI+P +Y Sbjct 367 WCLPAGFGSPIPYFYVAYFGVLLVHRNARDDHKCRVKYGEDWEKYCKAVKYRIIPYVY 424 >RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=Integral nuclear envelope inner membrane protein; AltName: Full=Lamin-B receptor; AltName: Full=NBP60; AltName: Full=Sterol C14-reductase [Rattus norvegicus] Sequence ID: O08984.1 Length: 620 Range 1: 221 to 620 Score:305 bits(780), Expect:2e-96, Method:Compositional matrix adjust., Identities:174/409(43%), Positives:234/409(57%), Gaps:16/409(3%) Query 26 LVLMIALPPLVYYLWI-CVTYYQGELVFTSDAAAWRRFWSHVAPPTWHAAGLYAAWFLGQ 84 L++M+ LP V+ L + C G L F A R W G+Y WF Q Sbjct 221 LLIMLGLPACVFLLLLQCAQKDPGLLQFPPPLPALRELWEA------RVCGVYLLWFFLQ 274 Query 85 AALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLGP 144 A + G V+G L DG RL YR+NG+++F+ T A V G ++ LY Sbjct 275 ALFSLLPVGKVVEGTPLVDGRRLKYRLNGLYAFILTSAAV-GTAVFWDIELYYLYTHFLQ 333 Query 145 LLTVVNIFTFVFAGFLYFWGLNGKQWE---RPTGRPFYDYFMGTALNPRIGSLDLKLFCE 201 +F+ V + +LY L + E +G YD+F+G LNPRIG+ DLK FCE Sbjct 334 FALAAIVFSVVLSVYLYARSLKVPRDELSPASSGNAVYDFFIGRELNPRIGAFDLKFFCE 393 Query 202 ARPGMIFWLLMNLSM--AAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIK 259 RPG+I W+++NL M A + + ++ M LV FQ Y++D EEA+LTT DI Sbjct 394 LRPGLIGWVVINLVMLLAEMKVQERSAPSLAMTLVNSFQLLYVVDALWFEEALLTTMDII 453 Query 260 HEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIA-IVALNLAGYAIFRGANIQ 318 H+ FG+ML +GDLVW+PFTY+LQA YLV+H DL W + + I+AL L GY IFR AN Q Sbjct 454 HDGFGFMLAFGDLVWVPFTYSLQAFYLVNHPQDLS-WPLTSVIIALKLCGYVIFRCANSQ 512 Query 319 KHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGS 378 K+ FR++P K I T LL SGWWG RH NY GDL++AL+W LP F Sbjct 513 KNAFRKNPTDPKLAH-LKTIPTSTWKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNH 571 Query 379 PIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +PYF+++YFT LL+HRE RD+ C KYG W +Y ++VP+RI P IY Sbjct 572 ILPYFYVIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY 620 >RecName: Full=Delta(14)-sterol reductase TM7SF2; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=Another new gene 1 protein; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=Putative sterol reductase SR-1; AltName: Full=Sterol C14-reductase; AltName: Full=Transmembrane 7 superfamily member 2 [Homo sapiens] Sequence ID: O76062.3 Length: 418 Range 1: 73 to 418 Score:298 bits(762), Expect:2e-96, Method:Compositional matrix adjust., Identities:159/350(45%), Positives:217/350(62%), Gaps:10/350(2%) Query 84 QAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLG 143 QAAL + +G +L D SRL Y +NG + + T A++ GL L L + L Sbjct 73 QAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLT-ALLVGLGMSAGLPLGALPEMLL 131 Query 144 PLLTVVNIFTFVFAGFLYFWG----LNGKQWERPTGRPFYDYFMGTALNPRIGSLDLKLF 199 PL V + F+F+ FLY ++ +G P YD+F+G LNPRI D K F Sbjct 132 PLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYF 191 Query 200 CEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIK 259 CE RPG+I W+L+NL++ K+ EL G+ ++ M LV GFQ Y+ D HEEAVLTT DI Sbjct 192 CELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDIT 251 Query 260 HEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRGANIQK 319 H+ FG+ML +GD+ W+PFTY+LQAQ+L+HH L + I +N GY IFRGAN QK Sbjct 252 HDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQK 311 Query 320 HHFRRDPN--RIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFG 377 + FR++P+ R+ + I T G LL SGWWG+ RH NY GDL++AL+W LP Sbjct 312 NTFRKNPSDPRVAG---LETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVS 368 Query 378 SPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +PYF+++YFT LL+HRE RD+ CL KYG W +Y ++VP+RI+P IY Sbjct 369 HLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY 418 >RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=Integral nuclear envelope inner membrane protein; AltName: Full=Lamin-B receptor; AltName: Full=Sterol C14-reductase [Mus musculus] Sequence ID: Q3U9G9.2 Length: 626 Range 1: 227 to 626 Score:303 bits(776), Expect:6e-96, Method:Compositional matrix adjust., Identities:171/409(42%), Positives:235/409(57%), Gaps:16/409(3%) Query 26 LVLMIALPPLVYYLWI-CVTYYQGELVFTSDAAAWRRFWSHVAPPTWHAAGLYAAWFLGQ 84 +++M+ LP V L + C G L F A W G+Y WF Q Sbjct 227 VLIMLGLPACVLLLLLQCRQKDPGLLHFPPPLPALHELWEP------RVCGVYLLWFFVQ 280 Query 85 AALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLGP 144 A + G +G L DG RL YR+NG+++F+ T A + V G ++ LY Sbjct 281 ALFHLLPVGKVAEGTPLVDGRRLQYRLNGLYAFILTSAALGAAVFWG-VELCYLYTHFLQ 339 Query 145 LLTVVNIFTFVFAGFLYFWGLNGKQWE---RPTGRPFYDYFMGTALNPRIGSLDLKLFCE 201 L F+ + + +LY L + E +G YD+F+G LNPR+G+ DLK FCE Sbjct 340 LALAATGFSVLLSAYLYVRSLRAPREELSPASSGNAVYDFFIGRELNPRLGAFDLKFFCE 399 Query 202 ARPGMIFWLLMNLSMAAKQYELH--GTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIK 259 RPG+I W+++NL M + ++ ++ M+LV FQ Y++D +EEA+LT+ DI Sbjct 400 LRPGLIGWVVINLVMLLMEMKIQERAAPSLAMILVNSFQLLYVVDALWNEEALLTSMDIM 459 Query 260 HEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIA-IVALNLAGYAIFRGANIQ 318 H+ FG+ML +GDLVW+PFTY+LQA YLV H HDL W + + I+AL L GY IFR AN Q Sbjct 460 HDGFGFMLAFGDLVWVPFTYSLQAFYLVSHPHDLS-WPLASVIIALKLCGYVIFRCANSQ 518 Query 319 KHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGS 378 K+ FR++P K I T G LL SGWWG RH NY GDL++AL+W LP F Sbjct 519 KNAFRKNPTDPKLAH-LKTIHTSTGKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNH 577 Query 379 PIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +PYF+I+YFT LL+HRE RD+ C KYG W +Y ++VP+RI P IY Sbjct 578 LLPYFYIIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY 626 >RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=Integral nuclear envelope inner membrane protein; AltName: Full=LMN2R; AltName: Full=Lamin-B receptor; AltName: Full=Sterol C14-reductase [Homo sapiens] Sequence ID: Q14739.2 Length: 615 Range 1: 260 to 615 Score:295 bits(755), Expect:5e-93, Method:Compositional matrix adjust., Identities:157/359(44%), Positives:218/359(60%), Gaps:9/359(2%) Query 75 GLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLD 134 G+Y WFL Q + G V+G L DG RL YR+NG ++F+ T AV+ G ++ Sbjct 260 GVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAVI-GTSLFQGVE 318 Query 135 ATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWE---RPTGRPFYDYFMGTALNPRI 191 +Y +F V + +LY L + + +G YD+F+G LNPRI Sbjct 319 FHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRI 378 Query 192 GSLDLKLFCEARPGMIFWLLMNLSM--AAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHE 249 G+ DLK FCE RPG+I W+++NL M A + + ++ M+LV FQ Y++D +E Sbjct 379 GTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNE 438 Query 250 EAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIA-IVALNLAG 308 EA+LTT DI H+ FG+ML +GDLVW+PF Y+ QA YLV H +++ W + + I+ L L G Sbjct 439 EALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVS-WPMASLIIVLKLCG 497 Query 309 YAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIAL 368 Y IFRGAN QK+ FR++P+ K I T G LL SGWWG RH NY GDL++AL Sbjct 498 YVIFRGANSQKNAFRKNPSDPKLAH-LKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMAL 556 Query 369 SWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +W LP F +PYF+I+YFT+LL+HRE RD+ C KYG W +Y ++VP+RI P IY Sbjct 557 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615 >RecName: Full=Delta(14)-sterol reductase TM7SF2; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=Sterol C14-reductase; AltName: Full=Transmembrane 7 superfamily member 2 [Mus musculus] Sequence ID: Q71KT5.2 Length: 418 Range 1: 73 to 418 Score:288 bits(738), Expect:8e-93, Method:Compositional matrix adjust., Identities:152/348(44%), Positives:213/348(61%), Gaps:6/348(1%) Query 84 QAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLG 143 Q AL + +G++L D SRL Y +NG + + T A++ GL L L L Sbjct 73 QVALYLLPARKVAEGLELKDKSRLRYPINGFQALVLT-ALLMGLGVSVGLPLGALPGMLL 131 Query 144 PLLTVVNIFTFVFAGFLYFWGLNGKQWERP----TGRPFYDYFMGTALNPRIGSLDLKLF 199 PL + +F+F+ LY L +G YD+F+G LNPR+GS D K F Sbjct 132 PLAFATTLTSFIFSLLLYAKALVAPASALAPGGNSGNSMYDFFLGRELNPRLGSFDFKYF 191 Query 200 CEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIK 259 CE RPG+I W+ +NL++ ++ EL G+ ++ M LV GFQ Y+ D +EE+VLTT DI Sbjct 192 CELRPGLIGWVFINLALLMQEAELRGSPSLAMWLVNGFQLLYVGDALWYEESVLTTMDII 251 Query 260 HEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRGANIQK 319 H+ FG+ML +GDL W+PFTY+LQAQ+L++H L + + I L + GY IFRGAN QK Sbjct 252 HDGFGFMLVFGDLAWVPFTYSLQAQFLLYHPQPLGLPMALLICLLKVIGYYIFRGANSQK 311 Query 320 HHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSP 379 + FR++P+ + I T G LL SGWWG+ RH NY GDL++AL+W LP Sbjct 312 NTFRKNPSDPSVAG-LETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHL 370 Query 380 IPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +PYF+++YFT LL+HRE RD+ CL KYG W +Y K+VP+RI+P +Y Sbjct 371 LPYFYVLYFTALLVHREARDEQQCLQKYGRAWQEYCKRVPYRIIPYVY 418 >RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=Integral nuclear envelope inner membrane protein; AltName: Full=Lamin-B receptor; AltName: Full=Sterol C14-reductase [Pongo abelii] Sequence ID: Q5R7H4.1 Length: 615 Range 1: 260 to 615 Score:292 bits(748), Expect:6e-92, Method:Compositional matrix adjust., Identities:156/359(43%), Positives:217/359(60%), Gaps:9/359(2%) Query 75 GLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLD 134 G+Y WFL Q + G V+G L DG RL YR+NG ++F+ T AV+ G ++ Sbjct 260 GVYLLWFLIQVVFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAVI-GTSLFQGVE 318 Query 135 ATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWE---RPTGRPFYDYFMGTALNPRI 191 +Y +F V + +LY L + + +G YD+F+G LNPRI Sbjct 319 FHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRI 378 Query 192 GSLDLKLFCEARPGMIFWLLMNLSM--AAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHE 249 G+ DLK FCE RPG+I W+++NL M A + + ++ M+LV FQ Y++D +E Sbjct 379 GTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNE 438 Query 250 EAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIA-IVALNLAG 308 EA+LTT DI H+ FG+ML +GDLVW+PF Y+ QA YLV H +++ W + + I+ L G Sbjct 439 EALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVS-WPMASLIIVLKFCG 497 Query 309 YAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIAL 368 Y IFRGAN QK+ FR++P+ K I T G LL SGWWG ARH NY GDL++AL Sbjct 498 YVIFRGANSQKNAFRKNPSDPKLAH-LKTIHTSTGKNLLVSGWWGFARHPNYLGDLIMAL 556 Query 369 SWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +W L F +PYF+I+YFT+LL+HRE RD+ C KYG W +Y ++VP+RI P IY Sbjct 557 AWSLACGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615 >RecName: Full=Delta(14)-sterol reductase ERG24; AltName: Full=C-14 sterol reductase ERG24; AltName: Full=Sterol C14-reductase ERG24 [Candida albicans SC5314] Sequence ID: A0A1D8PIC7.1 Length: 448 Range 1: 22 to 448 Score:284 bits(727), Expect:9e-91, Method:Compositional matrix adjust., Identities:174/441(39%), Positives:249/441(56%), Gaps:53/441(12%) Query 26 LVLMIALPPL--VYYLWICVTY-----------YQGELVFTSDAAAWRRFWSHVAPPTWH 72 L + I LP L ++YL TY + +L T D W V T Sbjct 22 LGITIGLPTLTVLFYLLCNQTYSIHGINVDFAKIKSQLPITQD-----ELWQLVFDKTCW 76 Query 73 AAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGW 132 +A Y AWF L PG ++ G+KL DG+ L+Y++NG+ + ++ + Sbjct 77 SA--YLAWFFILVILDYLLPGKSLNGVKLRDGTVLNYKINGLSMSSLLIVLLLARLFQSN 134 Query 133 LDATV---------LYDQLGPLLTVVNIFTFVFAGFLYFW---------GLNGKQ----W 170 D+++ +YD L+ + +F+F+ A F+Y G+ K+ Sbjct 135 SDSSLEYYLPELQFIYDNQLQLIIICFLFSFMLAVFVYIISFIPLAKPNGIGTKERILSI 194 Query 171 ERPTGRPFYDYFMGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVP 230 TG PFYD+F+G LNPRIGS D+KLFCE RPGM+ WLL+NLS QY G VT Sbjct 195 NGNTGNPFYDWFIGRELNPRIGSWDIKLFCELRPGMLLWLLINLSCLHYQYHNLGYVTDS 254 Query 231 MLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHT 290 M++V Q+FY+ D ++EE LT DI + FG+ML +GDL W+P+TY+LQA+YL Sbjct 255 MIVVNLLQAFYIFDGVLNEEGCLTMIDITTDGFGFMLSFGDLAWVPWTYSLQARYLSIKG 314 Query 291 HDLPV-WGI-IAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGK--PAKYIKTKQGSLL 346 +++ + W + + IV L G+ IFR AN QK FR+ GK K I+TK GS L Sbjct 315 NEVNLGWTLSLLIVGLQALGFYIFRSANKQKSDFRQ-------GKLPHLKSIQTKTGSKL 367 Query 347 LTSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAK 406 L GWWG+++H+NY GD +I LSWCLP F +P+ YF+++YF LL+HR+ RD+ C AK Sbjct 368 LVEGWWGLSQHINYLGDWLIGLSWCLPTGFQTPLTYFYVIYFASLLIHRQVRDEMKCRAK 427 Query 407 YGEDWLQYRKKVPWRIVPKIY 427 YGEDW +Y K VP++I+P +Y Sbjct 428 YGEDWEKYEKLVPYKIIPYVY 448 >RecName: Full=Delta(14)-sterol reductase TM7SF2; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=C-14 sterol reductase; AltName: Full=Sterol C14-reductase; AltName: Full=Transmembrane 7 superfamily member 2 [Bos taurus] Sequence ID: Q8WMV1.1 Length: 418 Range 1: 73 to 418 Score:275 bits(702), Expect:2e-87, Method:Compositional matrix adjust., Identities:155/350(44%), Positives:212/350(60%), Gaps:10/350(2%) Query 84 QAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLG 143 QAAL + +G +L D SRL Y NG + + T A++ GL L + L + L Sbjct 73 QAALYLLPARKVAEGQELKDKSRLRYPTNGFQALVLT-ALLVGLGVSAGLPLSALPEMLL 131 Query 144 PLLTVVNIFTFVFAGFLYFWGLNGKQWER----PTGRPFYDYFMGTALNPRIGSLDLKLF 199 PL + F+F+ LY L +G YD+F+G LNPRI S D K F Sbjct 132 PLAFAATLTAFIFSLLLYLKALLAPASALAPGGNSGNLIYDFFLGRELNPRICSFDFKYF 191 Query 200 CEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIK 259 CE RPG+I W+L+NL++ ++ EL G+ ++ M LV GFQ Y+ D +EEAVLTT DI Sbjct 192 CELRPGLIGWVLINLALLIQEAELRGSPSLAMWLVNGFQLLYVGDALWYEEAVLTTMDII 251 Query 260 HEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDL--PVWGIIAIVALNLAGYAIFRGANI 317 H+ FG+ML +GDL W+PFTY+LQAQ+L++H L P+ I ++ N GY IFRGAN Sbjct 252 HDGFGFMLAFGDLAWVPFTYSLQAQFLLYHPQPLGWPLASFICLI--NAVGYYIFRGANS 309 Query 318 QKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFG 377 QK+ FR++P+ + I T G LL SGWWG+ RH NY GDL++AL+W LP Sbjct 310 QKNTFRKNPSDPRVAD-LETISTATGRRLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVF 368 Query 378 SPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +PYF+ +YFT LL+HRE RD+ C KYG W +Y ++VP+RIVP +Y Sbjct 369 HLLPYFYFLYFTALLVHREDRDERQCRQKYGLAWHEYCRRVPYRIVPYVY 418 >RecName: Full=Delta(14)-sterol reductase LBR; Short=Delta-14-SR; AltName: Full=3-beta-hydroxysterol Delta (14)-reductase; AltName: Full=C-14 sterol reductase; Short=C14SR; AltName: Full=Integral nuclear envelope inner membrane protein; AltName: Full=Lamin-B receptor; AltName: Full=Sterol C14-reductase [Gallus gallus] Sequence ID: P23913.1 Length: 637 Range 1: 201 to 601 Score:279 bits(714), Expect:1e-86, Method:Compositional matrix adjust., Identities:162/413(39%), Positives:224/413(54%), Gaps:22/413(5%) Query 18 KYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWRRFWSHVAPPTWHAAGLY 77 ++G F +LM LP V YL + L+ A W G++ Sbjct 201 EFGGRFGTFMLMFFLPATVLYLVLMCKQDDPSLMNFPPLPALESLWE------TKVFGVF 254 Query 78 AAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATV 137 WF QA + G V+G+ L + +L YR+NG ++FL T A + G + + Sbjct 255 LLWFFFQALFYLLPIGKVVEGLPLSNPRKLQYRINGFYAFLLTAAAI-GTLLYFQFELHY 313 Query 138 LYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWE-RPTGRP---FYDYFMGTALNPRIGS 193 LYD F+ + +LY L + + P G YD+F G LNPRIGS Sbjct 314 LYDHFVQFAVSAAAFSMALSIYLYIRSLKAPEEDLAPGGNSGYLVYDFFTGHELNPRIGS 373 Query 194 LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTV--TVPMLLVVGFQSFYLIDYFIHEEA 251 DLK FCE RPG+I W+++NL+M + ++H ++ M+LV FQ Y++D +EEA Sbjct 374 FDLKYFCELRPGLIGWVVINLAMLLAEMKIHNQSMPSLSMILVNSFQLLYVVDALWNEEA 433 Query 252 VLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAI 311 VLTT DI H+ FG+ML +GDLVW+PF Y+LQA YLV H + AI LN GY I Sbjct 434 VLTTMDITHDGFGFMLAFGDLVWVPFVYSLQAFYLVGHPIAISWPVAAAITILNCIGYYI 493 Query 312 FRGANIQKHHFRRDPNRIVWGKPA----KYIKTKQGSLLLTSGWWGIARHMNYFGDLMIA 367 FR AN QK++FRR+P P K I T G LL +GWWG RH NY GD+++A Sbjct 494 FRSANSQKNNFRRNP-----ADPKLSYLKVIPTATGKGLLVTGWWGFVRHPNYLGDIIMA 548 Query 368 LSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPW 420 L+W LP F +PYF+++YF LL+HRE RD+ C KYG W +Y ++VP+ Sbjct 549 LAWSLPCGFNHILPYFYVIYFICLLVHREARDEHHCKKKYGLAWERYCQRVPY 601 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Xenopus laevis] Sequence ID: Q7ZXH1.1 Length: 473 Range 1: 36 to 473 Score:274 bits(701), Expect:2e-86, Method:Compositional matrix adjust., Identities:170/439(39%), Positives:234/439(53%), Gaps:33/439(7%) Query 21 FGFSWLVLMIALPPL-VYYLWICVTYYQGELV-----FTSDAAAWRRFWSHVAPPTWHAA 74 F + ++ ++A PL VYY + YQ L S A W TW A Sbjct 36 FSLASVIFLLAFAPLIVYYFVMSCDQYQCALTAPVLDLYSGKARLSDIWDKTPALTWTAV 95 Query 75 GLYAAWFLGQAALQVWAP-----------GPTVQGMKLPDGSRLDYRMNGIFSFLFTLAV 123 +Y AW Q L ++ P G +G + P G Y++NG+ ++ T + Sbjct 96 KIYLAWVSFQVFLYMFLPDILHKFVPGYEGGVQEGARTPAGLINKYQVNGLQAWTITHLL 155 Query 124 VFGLV-TMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLY----FWGLNGKQWERPTGRPF 178 F W T++ D PLL N+ + A F F+ N + TG F Sbjct 156 WFANAYHFHWFSPTIVIDNWIPLLWCANLLGYSVATFALVKANFFPTNANDC-KFTGNFF 214 Query 179 YDYFMGTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGF 237 YDY MG NPRIG D KLF RPG++ W L+NLS AAKQ EL+G VT M+LV Sbjct 215 YDYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGQVTNSMILVNVL 274 Query 238 QSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWG 297 Q+ Y++D+F +E L T DI H+ FGW L WGD VWLP+ YTLQ YLV++ +L Sbjct 275 QAIYVVDFFWNESWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYNPVELSTTA 334 Query 298 IIAIVALNLAGYAIFRGANIQKHHFRR-DPNRIVWGKPAKYIKT--------KQGSLLLT 348 +A++ L L GY IFR N QK FRR + N +WGK K I+ + S L+ Sbjct 335 AVAVLLLGLIGYYIFRMTNHQKDLFRRTNGNCKIWGKKPKSIECFYVSADGKRHYSKLMI 394 Query 349 SGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYG 408 SG+WG+ARH+NY GDLM +L++CL F +PYF+ +Y TILL+HR RD+ C +KYG Sbjct 395 SGFWGVARHLNYTGDLMGSLAYCLACGFDHLLPYFYFIYMTILLVHRCIRDEHRCSSKYG 454 Query 409 EDWLQYRKKVPWRIVPKIY 427 +DW Y VP+R++P ++ Sbjct 455 KDWKLYTSAVPYRLLPGLF 473 >RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14 sterol reductase; AltName: Full=Sterol C14-reductase [Ascobolus immersus] Sequence ID: P78575.1 Length: 430 Range 1: 16 to 430 Score:272 bits(696), Expect:2e-86, Method:Compositional matrix adjust., Identities:173/432(40%), Positives:240/432(55%), Gaps:48/432(11%) Query 27 VLMIALPPLVYYLWICVTYYQGELVFTSDAAAWRRFWS------HVAPPTW------HAA 74 VLM+ LPP+ +YL + T A FWS PT+ HA Sbjct 16 VLMLILPPISHYL---------HFLITPRGAPPPEFWSAPLETLKSVTPTFSSLFSLHAT 66 Query 75 GLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLF------TLAVVFGLV 128 AA++L AL P +G+ L DGSRL YR N +FL T+ V+ G Sbjct 67 LAVAAYYLLLVALMYVLPAEIAEGVVLKDGSRLKYRCNAFTTFLVFFTFLGTMTVLEGPT 126 Query 129 TMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL----NGKQWERP----TGRPFYD 180 W + L D L + +F++ + ++Y GK+ G +D Sbjct 127 WWFW---SYLTDNFAQLQSASIVFSYAMSLWVYIRSYRPMPKGKEVILSPVGFKGNHIHD 183 Query 181 YFMGTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQS 239 ++MG LNPRIG LD+K E RPG++ W+L NL+ KQY HG V+ ++LV F++ Sbjct 184 FWMGRELNPRIGEWLDIKQLHELRPGLMGWILFNLAWTVKQYNTHGFVSDSIVLVNLFET 243 Query 240 FYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGII 299 +Y++D +E VLTT DI + G ML +G+ VW+PF Y LQA+YL L + GI Sbjct 244 WYVVDALWNESKVLTTMDITTDGLGVMLLFGNAVWVPFMYCLQARYLASFPVHLGLLGIA 303 Query 300 AIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPA----KYIKTKQGSLLLTSGWWGIA 355 ++A+ GYAIFRGAN QK+ FR +P PA K++ TK GS LL SGWWG+A Sbjct 304 GVLAVQFTGYAIFRGANNQKNAFRTNP-----ADPAVSHLKFMTTKSGSKLLISGWWGVA 358 Query 356 RHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYR 415 RH+NYFGD ++A S+CL F +P+ YF+++YF ILLLHR++RD+A C KYG+DW +Y Sbjct 359 RHVNYFGDWIMAWSYCLTTGFNTPLTYFYVIYFGILLLHRDRRDEAKCREKYGKDWDRYC 418 Query 416 KKVPWRIVPKIY 427 K V WRI+P IY Sbjct 419 KVVKWRIIPGIY 430 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Mus musculus] Sequence ID: O88455.1 Length: 471 Range 1: 38 to 471 Score:271 bits(693), Expect:2e-85, Method:Compositional matrix adjust., Identities:174/434(40%), Positives:229/434(52%), Gaps:30/434(6%) Query 24 SWLVLMIALPPLVYYLWICVTYYQGELV-----FTSDAAAWRRFWSHVAPPTWHAAGLYA 78 S + L++ P +VYY + Y L + A+ W+ P T AA LYA Sbjct 38 SIIFLLLFAPFIVYYFIMACDQYSCSLTAPALDIATGHASLADIWAKTPPVTAKAAQLYA 97 Query 79 AWFLGQAALQVWAP-----------GPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVF-G 126 W Q L W P G +G P G Y +NG+ ++L T + F Sbjct 98 LWVSFQVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGVVNKYEVNGLQAWLITHILWFVN 157 Query 127 LVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL---NGKQWERPTGRPFYDYFM 183 + W T+++D PLL NI + + F G + + TG FY+Y M Sbjct 158 AYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMM 217 Query 184 GTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYL 242 G NPRIG D KLF RPG++ W L+NLS AAKQ EL+G VT M+LV Q+ Y+ Sbjct 218 GIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYV 277 Query 243 IDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIV 302 +D+F +E L T DI H+ FGW L WGD VWLP+ YTLQ YLV+H L + I+ Sbjct 278 LDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGIL 337 Query 303 ALNLAGYAIFRGANIQKHHFRRDPNR-IVWGKPAKYIKT--------KQGSLLLTSGWWG 353 L L GY IFR N QK FRR R ++WGK K I+ K S LL SG+WG Sbjct 338 LLGLVGYYIFRMTNHQKDLFRRTDGRCLIWGKKPKAIECSYTSADGLKHHSKLLVSGFWG 397 Query 354 IARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQ 413 +ARH NY GDLM +L++CL G +PYF+I+Y TILL HR RD+ C KYG DW + Sbjct 398 VARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWER 457 Query 414 YRKKVPWRIVPKIY 427 Y VP+R++P I+ Sbjct 458 YTAAVPYRLLPGIF 471 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Xenopus tropicalis] Sequence ID: Q6P4M0.1 Length: 473 Range 1: 36 to 473 Score:271 bits(692), Expect:4e-85, Method:Compositional matrix adjust., Identities:169/439(38%), Positives:232/439(52%), Gaps:33/439(7%) Query 21 FGFSWLVLMIALPPL-VYYLWICVTYYQGELVFTSDAAAWRR-----FWSHVAPPTWHAA 74 F + ++ ++A PL VYY + YQ L W + W TW AA Sbjct 36 FSLAAVLFLLAFAPLIVYYFVMSCDQYQCALTAPVLDLYWGKAQLSDIWDKTPALTWGAA 95 Query 75 GLYAAWFLGQAALQVWAP-----------GPTVQGMKLPDGSRLDYRMNGIFSFLFTLAV 123 +Y W Q L + P G +G + P G Y++NG+ ++ T + Sbjct 96 KIYIVWVSFQVFLYMLVPDILHKFVPGYEGGVQEGARTPAGLINKYQVNGLQAWTITHLL 155 Query 124 VFGLV-TMGWLDATVLYDQLGPLLTVVNIFTFVFAGFL----YFWGLNGKQWERPTGRPF 178 F W T++ D PLL N+ + A F YF+ N + TG F Sbjct 156 WFANAYHFHWFSPTIIIDNWVPLLWCANLLGYSVATFALLKAYFFPTNAHD-CKFTGNFF 214 Query 179 YDYFMGTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGF 237 YDY MG NPRIG D KLF RPG++ W L+NLS AAKQ EL+G VT M+LV Sbjct 215 YDYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGQVTNSMILVNVL 274 Query 238 QSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWG 297 Q+ Y++D+F +E L T DI H+ FGW L WGD VWLP+ YTLQ YLV++ +L Sbjct 275 QAIYVVDFFWNESWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYNPVELSTAT 334 Query 298 IIAIVALNLAGYAIFRGANIQKHHFRR-DPNRIVWGKPAKYIKT--------KQGSLLLT 348 + ++ L L GY IFR N QK FRR + N +WGK K I+ + S L+ Sbjct 335 AVGVLLLGLIGYYIFRMTNHQKDLFRRTNGNCKIWGKKPKSIECSYTSADGKRHYSKLMI 394 Query 349 SGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYG 408 SG+WG+ARH+NY GDLM +L++CL F +PYF+ Y TILL+HR RD+ C +KYG Sbjct 395 SGFWGVARHLNYTGDLMGSLAYCLACGFDHLLPYFYFTYMTILLVHRCIRDEHRCSSKYG 454 Query 409 EDWLQYRKKVPWRIVPKIY 427 +DW Y VP+R++P ++ Sbjct 455 KDWKLYTDAVPYRLLPGLF 473 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Danio rerio] Sequence ID: Q7SXF1.1 Length: 478 Range 1: 41 to 478 Score:270 bits(691), Expect:5e-85, Method:Compositional matrix adjust., Identities:170/440(39%), Positives:232/440(52%), Gaps:35/440(7%) Query 21 FGFSWLVLMIALPP-LVYYLWICVTYYQGEL------VFTSDAAAWRRFWSHVAPPTWHA 73 F S ++L++ P LV + + YQ + ++ DA + W+ TW A Sbjct 41 FSLSGVILLLCFAPFLVSFFIMACDQYQCSISHPLLDLYNGDATLFT-IWNRAPSFTWAA 99 Query 74 AGLYAAWFLGQAALQVWAP-----------GPTVQGMKLPDGSRLDYRMNGIFSFLFTLA 122 A +YA W Q L + P G G + P G Y +NG+ +L T Sbjct 100 AKIYAIWVTFQVVLYMCVPDFLHKILPGYVGGVQDGARTPAGLINKYEVNGLQCWLITHV 159 Query 123 V-VFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFL----YFWGLNGKQWERPTGRP 177 + V W T++ D PLL NI + + F Y + N + + TG Sbjct 160 LWVLNAQHFHWFSPTIIIDNWIPLLWCTNILGYAVSTFAFIKAYLFPTNPEDC-KFTGNM 218 Query 178 FYDYFMGTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVG 236 FY+Y MG NPRIG D KLF RPG++ W L+NLS AAKQ EL+G VT M+LV Sbjct 219 FYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGYVTNSMILVNV 278 Query 237 FQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVW 296 Q+ Y++D+F +E L T DI H+ FGW L WGD VWLPF YTLQ YLV++ L Sbjct 279 LQAVYVVDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPFLYTLQGLYLVYNPIQLSTP 338 Query 297 GIIAIVALNLAGYAIFRGANIQKHHFRR-DPNRIVWGKPAKYIKTK--------QGSLLL 347 ++ L L GY IFR N QK FRR + N +WGK +I+ S L+ Sbjct 339 HAAGVLILGLVGYYIFRVTNHQKDLFRRTEGNCSIWGKKPTFIECSYQSADGAIHKSKLM 398 Query 348 TSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKY 407 TSG+WG+ARHMNY GDLM +L++CL +PYF+I+Y TILL+HR RD+ C KY Sbjct 399 TSGFWGVARHMNYTGDLMGSLAYCLACGGNHLLPYFYIIYMTILLVHRCIRDEHRCSNKY 458 Query 408 GEDWLQYRKKVPWRIVPKIY 427 G+DW +Y V +R++P I+ Sbjct 459 GKDWERYTAAVSYRLLPNIF 478 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Rattus norvegicus] Sequence ID: Q9Z2Z8.1 Length: 471 Range 1: 38 to 471 Score:270 bits(690), Expect:8e-85, Method:Compositional matrix adjust., Identities:173/434(40%), Positives:230/434(52%), Gaps:30/434(6%) Query 24 SWLVLMIALPPLVYYLWICVTYYQGELV-----FTSDAAAWRRFWSHVAPPTWHAAGLYA 78 S + L++ P +VYY + Y L + A+ W+ P T AA LYA Sbjct 38 SVIFLLLFAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYA 97 Query 79 AWFLGQAALQVWAP-----------GPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVF-G 126 W Q L W P G +G P G Y +NG+ ++L T + F Sbjct 98 LWVSFQVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVN 157 Query 127 LVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL---NGKQWERPTGRPFYDYFM 183 + W T+++D PLL NI + + F G + + TG FY+Y M Sbjct 158 AYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMM 217 Query 184 GTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYL 242 G NPRIG D KLF RPG++ W L+NLS AAKQ EL+G VT M+LV Q+ Y+ Sbjct 218 GIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYV 277 Query 243 IDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIV 302 +D+F +E L T DI H+ FGW L WGD VWLP+ YTLQ YLV+H L + ++ Sbjct 278 LDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGVL 337 Query 303 ALNLAGYAIFRGANIQKHHFRR-DPNRIVWGKPAKYIKT--------KQGSLLLTSGWWG 353 L L GY IFR N QK FRR D + ++WGK K I+ K S LL SG+WG Sbjct 338 LLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLVSGFWG 397 Query 354 IARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQ 413 +ARH NY GDLM +L++CL G +PYF+I+Y TILL HR RD+ C KYG DW + Sbjct 398 VARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWER 457 Query 414 YRKKVPWRIVPKIY 427 Y VP+R++P I+ Sbjct 458 YVAAVPYRLLPGIF 471 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Bos taurus] Sequence ID: Q5E9J5.1 Length: 475 Range 1: 38 to 475 Score:270 bits(690), Expect:8e-85, Method:Compositional matrix adjust., Identities:170/439(39%), Positives:236/439(53%), Gaps:33/439(7%) Query 21 FGFSWLVLMIALPPLVYYLWI--CVTYYQGELVFTSDAAAWR----RFWSHVAPPTWHAA 74 F + ++ ++ P + Y +I C Y V +D A R W+ P T AA Sbjct 38 FSLASVIFLLLFAPFIVYYFIMACDQYGCSLTVPVADLATGRARLADIWARTPPVTAKAA 97 Query 75 GLYAAWFLGQAALQVWAP-----------GPTVQGMKLPDGSRLDYRMNGIFSFLFTLAV 123 +Y AW Q L + P G +G P G+ Y +NG+ ++L T + Sbjct 98 QIYTAWVTLQVLLYMLLPDFCHKFLPGYVGGVQEGAVTPAGAVNKYEINGLQAWLLTHLL 157 Query 124 VFGLV-TMGWLDATVLYDQLGPLLTVVNIFTFVFAGFL----YFWGLNGKQWERPTGRPF 178 F +GW T+++D PLL NI + + F Y + + ++ + TG F Sbjct 158 WFANAHLLGWFSPTIIFDNWIPLLWCANILGYTVSTFAMVKGYLFPTDARE-CKFTGNFF 216 Query 179 YDYFMGTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGF 237 Y+Y MG NPRIG D KLF RPG++ W L+NLS AAKQ EL+G VT M+LV Sbjct 217 YNYMMGVEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMVLVNIL 276 Query 238 QSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWG 297 Q+ Y++D+F +E L T DI H+ FGW L WGD VWLP+ YTLQ YLV+H LP + Sbjct 277 QAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLPTYY 336 Query 298 IIAIVALNLAGYAIFRGANIQKHHFRRDPNR-IVWGKPAKYIKT--------KQGSLLLT 348 + ++ L L GY IFR N QK FRR R ++WG+ K I+ + S LL Sbjct 337 ALGVLLLGLLGYYIFRMTNHQKDLFRRTDGRCLIWGRKPKAIECSYTSADGQRHHSKLLV 396 Query 349 SGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYG 408 SG+WG+ARH NY GDLM +L++CL G +PYF+I++ ILL HR RD+ C KYG Sbjct 397 SGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIFMAILLTHRCLRDEHRCANKYG 456 Query 409 EDWLQYRKKVPWRIVPKIY 427 DW Y VP+R++P I+ Sbjct 457 RDWEHYTAAVPYRLLPGIF 475 >RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14 sterol reductase; AltName: Full=Protein FACKEL; AltName: Full=Sterol C14-reductase [Arabidopsis thaliana] Sequence ID: Q9LDR4.2 Length: 369 Range 1: 12 to 369 Score:266 bits(680), Expect:1e-84, Method:Compositional matrix adjust., Identities:147/364(40%), Positives:222/364(60%), Gaps:11/364(3%) Query 69 PTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLV 128 P+ + + +F+ A PG ++G+ L DGS+L YR NG+ + + +A++ Sbjct 12 PSLQSVYVLVFYFVYLAVAGEILPGKVIRGVLLSDGSQLRYRCNGLLALILLVAILGICA 71 Query 129 TMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL---NGKQWERP--TGRPFYDYFM 183 +G + V+ D+ LL+ IF + LY G N +P +G +D++ Sbjct 72 KLGIVSPLVVADRGLELLSATFIFCVLVTLALYVTGRSSSNKGSSLKPHVSGNLVHDWWF 131 Query 184 GTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLI 243 G LNP+ S+DLK F R GM+ WLL+NLS+ AK + G+++ M+L F + Y++ Sbjct 132 GIQLNPQFMSIDLKFFF-VRAGMMGWLLINLSILAKSVQ-DGSLSQSMILYQIFCALYIL 189 Query 244 DYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVA 303 DYF+HEE + +TWDI E+ G+ML +GDL+W+PFT+++Q +L+H+ +L V I+ Sbjct 190 DYFVHEEYMTSTWDIIAERLGFMLVFGDLLWIPFTFSIQGWWLLHNKVELTVPAIVVNCL 249 Query 304 LNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGD 363 + L GY +FRGAN QKH F+++P +WGKP + G LL SG+WGIARH NY GD Sbjct 250 VFLIGYMVFRGANKQKHIFKKNPKTPIWGKPPVVV----GGKLLVSGYWGIARHCNYLGD 305 Query 364 LMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIV 423 LM+ALS+ LP SP+PYF+ +Y ILL+ RE+RD+ C KY E W +Y + VPWRI+ Sbjct 306 LMLALSFSLPCGISSPVPYFYPIYLLILLIWRERRDEVRCAEKYKEIWAEYLRLVPWRIL 365 Query 424 PKIY 427 P +Y Sbjct 366 PYVY 369 >RecName: Full=Delta(14)-sterol reductase ERG24; AltName: Full=C-14 sterol reductase ERG24; AltName: Full=Ergosterol biosynthetic protein 24; AltName: Full=Sterol C14-reductase ERG24 [Saccharomyces cerevisiae S288C] Sequence ID: P32462.1 Length: 438 Range 1: 55 to 438 Score:267 bits(683), Expect:2e-84, Method:Compositional matrix adjust., Identities:147/389(38%), Positives:223/389(57%), Gaps:27/389(6%) Query 61 RFWSHVAPPTWHAAG-----LYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGI- 114 W+ + P ++ +Y W+ A L V PG ++G++L DGS+L Y++NGI Sbjct 55 ELWNGIKPLRYYLGNRELWTVYCLWYGILAVLDVILPGRVMKGVQLRDGSKLSYKINGIA 114 Query 115 --FSFLFTLAVVFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL------- 165 + + LA+ + L + LY+ L + +F+F A + Y Sbjct 115 MSTTLVLVLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKK 174 Query 166 --NGKQWE-----RPTGRPFYDYFMGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAA 218 NGK+ + +G YD+F+G LNPR+G LD+K+F E RPGM+ WLL+NLS Sbjct 175 NGNGKREKILALGGNSGNIIYDWFIGRELNPRLGPLDIKMFSELRPGMLLWLLINLSCLH 234 Query 219 KQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFT 278 Y G + ++LV Q FY+ D ++EE VLT DI + FG+ML +GDL +PFT Sbjct 235 HHYLKTGKINDALVLVNFLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFT 294 Query 279 YTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYI 338 Y+LQA+YL +L ++ I+A+ G+ IF AN QK FR+ + K I Sbjct 295 YSLQARYLSVSPVELGWVKVVGILAIMFLGFHIFHSANKQKSEFRQGKL-----ENLKSI 349 Query 339 KTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKR 398 +TK+G+ LL GWW ++H+NYFGD +I+LSWCL F +P+ Y++ +YF LLLHR++R Sbjct 350 QTKRGTKLLCDGWWAKSQHINYFGDWLISLSWCLATWFQTPLTYYYSLYFATLLLHRQQR 409 Query 399 DDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 D+ C KYGE+W +Y +KVP++I+P +Y Sbjct 410 DEHKCRLKYGENWEEYERKVPYKIIPYVY 438 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Delta7-sterol reductase; AltName: Full=Sterol Delta(7)-reductase; AltName: Full=Sterol reductase SR-2 [Homo sapiens] Sequence ID: Q9UBM7.1 Length: 475 Range 1: 9 to 475 Score:266 bits(681), Expect:2e-83, Method:Compositional matrix adjust., Identities:176/468(38%), Positives:240/468(51%), Gaps:42/468(8%) Query 1 MSEQESRDNAAVDAVRQKYGFGFSWLV----------LMIALPPLVYYLWICVTYYQGEL 50 + + +S D D + +G +W V L++ P +VYY + Y L Sbjct 9 IPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCAL 68 Query 51 V-----FTSDAAAWRRFWSHVAPPTWHAAGLYAAWFLGQAALQVWAP-----------GP 94 + A W+ P T AA LY W Q L P G Sbjct 69 TGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGG 128 Query 95 TVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLV-TMGWLDATVLYDQLGPLLTVVNIFT 153 +G P G Y++NG+ ++L T + F + W T+++D PLL NI Sbjct 129 IQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILG 188 Query 154 FVFAGFL----YFWGLNGKQWERPTGRPFYDYFMGTALNPRIGS-LDLKLFCEARPGMIF 208 + + F YF+ + + + TG FY+Y MG NPRIG D KLF RPG++ Sbjct 189 YAVSTFAMVKGYFFPTSARD-CKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVA 247 Query 209 WLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLC 268 W L+NLS AAKQ ELH VT M+LV Q+ Y+ID+F +E L T DI H+ FGW L Sbjct 248 WTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLG 307 Query 269 WGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRGANIQKHHFRRDPNR 328 WGD VWLP+ YTLQ YLV+H L + ++ L L GY IFR AN QK FRR R Sbjct 308 WGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGR 367 Query 329 -IVWGKPAKYIKT--------KQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSP 379 ++WG+ K I+ + S LL SG+WG+ARH NY GDLM +L++CL G Sbjct 368 CLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHL 427 Query 380 IPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +PYF+I+Y ILL HR RD+ C +KYG DW +Y VP+R++P I+ Sbjct 428 LPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 475 >RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14 sterol reductase; AltName: Full=Sterol C14-reductase [Neurospora crassa OR74A] Sequence ID: P38670.1 Length: 490 Range 1: 91 to 490 Score:265 bits(677), Expect:1e-82, Method:Compositional matrix adjust., Identities:158/404(39%), Positives:222/404(54%), Gaps:60/404(14%) Query 80 WFLGQAALQV----WAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVF-GLVTMG--- 131 W LG AL + + PG V+G +L G RL Y++N S + TLA++ G + G Sbjct 91 WTLGYYALSLVQYRFLPGHHVEGTELSTGGRLKYKLNAFNSAMCTLAILAAGTIAQGAEF 150 Query 132 --WLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWERP---------TGRPFYD 180 W T + D +++ +F F A F+Y + K + TG YD Sbjct 151 PVW---TFISDNFAQIISANILFAFALAIFVYVRSFDVKPGNKDMRQLAAGGVTGSLIYD 207 Query 181 YFMGTALNPRI-----GSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVV 235 +++G LNPRI G +D+K F E RPG++ W+++N + AKQY L+G VT +L + Sbjct 208 FYIGRELNPRITLPLIGQVDIKEFMEMRPGLLGWIILNCAFIAKQYRLYGYVTDSILFIT 267 Query 236 GFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPV 295 Q+FY+ D E AVLTT DI + FG+ML +GD+VW+PF Y+ Q +YL H L Sbjct 268 AIQAFYVFDGIYMEPAVLTTMDITTDGFGFMLSFGDVVWVPFMYSTQTRYLSVHPQQLGA 327 Query 296 WGIIAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIA 355 +G+IA+ A+ AGY+IFR +N QK++FR +P K Y++TK GS L+TSGWWGIA Sbjct 328 FGLIAVGAVLAAGYSIFRLSNSQKNNFRTNPEDPSV-KHLTYLQTKTGSRLITSGWWGIA 386 Query 356 RHMNYFGDLMIALSWCLPAAF--------GSPIP------------------------YF 383 RH+NY GD + + + LP GS P YF Sbjct 387 RHINYLGDWLQSWPYSLPTGIAGYQILSAGSNAPGAITMLDGREVVQGEARGWGIVFTYF 446 Query 384 HIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 +I+YF ILL+HR+ RDD C KYG+DW +Y+K V WRIVP IY Sbjct 447 YILYFAILLIHRDLRDDEKCSKKYGDDWEKYKKLVKWRIVPGIY 490 >RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14 sterol reductase; AltName: Full=Sterol C14-reductase [Fusarium vanettenii] Sequence ID: Q01447.1 Length: 485 Range 1: 80 to 485 Score:262 bits(670), Expect:8e-82, Method:Compositional matrix adjust., Identities:160/410(39%), Positives:222/410(54%), Gaps:56/410(13%) Query 70 TWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVF-GLV 128 +W A+ A + L L P V+G +L G RL YR+N ++S FTLA++ G Sbjct 80 SWEASAATAGYILLSLILYRVLPAHEVEGTELRSGGRLKYRLNTLYSSSFTLAILAAGTA 139 Query 129 TMG-----WLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLN---GKQWERP------T 174 G W T + D +LT IF++ A F+Y + G + R T Sbjct 140 AQGAEFPVW---TFISDNFIQILTANTIFSYAVATFVYVRSFSVKPGNKENRELAAGGHT 196 Query 175 GRPFYDYFMGTALNPR-----IGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTV 229 G YD+F+G LNPR IG +DLK + E RPGM+ W++ N S A+QY +G VT Sbjct 197 GNMLYDWFIGRELNPRVVIPLIGEVDLKEWLELRPGMMGWIIFNCSWCAQQYRNYGYVTD 256 Query 230 PMLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHH 289 + + Q+ Y+ D + +E A+LTT DI + FG ML +GD+VW+PF Y+LQ +YL H Sbjct 257 SSICITLVQAVYVFDSWWNEPAILTTMDITTDGFGMMLAFGDIVWVPFVYSLQTRYLAVH 316 Query 290 THDLPVWGIIAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTS 349 L G+ +++L G+ IFR AN +K++FR +PN + KYI+TK+GS LL S Sbjct 317 PVSLGPVGLAVMLSLIGLGFYIFRSANSEKNNFRTNPNDPKVSQ-LKYIQTKKGSKLLIS 375 Query 350 GWWGIARHMNYFGDLMIALSWCLPAAF--------------------------------G 377 GWWGIARH+NY GD + + +CLP G Sbjct 376 GWWGIARHINYLGDWIQSWPYCLPTGLAGYQILNAGAQAEGALVMRDGREVVQGEAKGWG 435 Query 378 SPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 I YF+I+YF ILL+HRE+RDD C KYGEDW +YRK V +RI+P IY Sbjct 436 MLITYFYILYFAILLIHRERRDDDKCHRKYGEDWEKYRKIVRYRIIPGIY 485 >RecName: Full=Probable 7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Acanthamoeba polyphaga mimivirus] Sequence ID: Q5UQI4.1 Length: 447 Range 1: 29 to 447 Score:256 bits(653), Expect:1e-79, Method:Compositional matrix adjust., Identities:154/421(37%), Positives:218/421(51%), Gaps:24/421(5%) Query 29 MIALPPLVYYLWICVTYYQ-----GELVFTSDAAAWRRFWSHVAPPTWHAAGLYAAWFLG 83 M P + ++ +TY + G+ W+ WS++ + G W + Sbjct 29 MFMFCPFIILVFYLITYGEYLGSIGDFYLDIINGDWQTIWSNIPSFKINVLGACLLWIVF 88 Query 84 QAALQV-------WAP---GPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWL 133 Q L + P G G P G+ + Y +NG+ +F+ T +V G Sbjct 89 QLILSKLPDTIHRFVPHYVGGIKAGHITPAGNLVYYNINGLQAFIITHVLVIMSCYYGLF 148 Query 134 DATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQW---ERPTGRPFYDYFMGTALNPR 190 T++ D G + VNI ++ YF L + TG+ FYD MG NP Sbjct 149 SPTIIMDNWGSIFWSVNIIGYLITFLAYFKALTFSSHPSDNKFTGKLFYDIVMGIEFNPE 208 Query 191 IGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEE 250 I DLKLF RPG+I W L+NLS A KQYE G V+ M+LV+ Q Y++D+F +E Sbjct 209 IFGTDLKLFFNGRPGIIAWNLINLSCAMKQYENFGYVSNSMILVIILQLIYIVDFFYNEN 268 Query 251 AVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYA 310 + T DI H+ FGWML WGD VWLPF YTLQA YL+++ DL + + + GY Sbjct 269 WYVHTVDIAHDHFGWMLAWGDTVWLPFGYTLQAGYLMNNPIDLSTGFFNLVFVMGIIGYI 328 Query 311 IFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQG----SLLLTSGWWGIARHMNYFGDLMI 366 IFR AN QK +R + + + P Y +T G S L+ SG WG++RHMNY GD+++ Sbjct 329 IFRTANYQKDKYRSNTQGVKY-IPCTY-QTADGLNRASKLIYSGLWGVSRHMNYTGDIIL 386 Query 367 ALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKI 426 + ++CL F IPYF+ VY TILL+ R RD+ C KYG+ W Y K+VP+R +P I Sbjct 387 STAYCLACGFSHFIPYFYCVYMTILLVTRCLRDEQRCSRKYGKYWKMYTKRVPYRFIPGI 446 Query 427 Y 427 Y Sbjct 447 Y 447 >RecName: Full=Delta(14)-sterol reductase ERG24A; AltName: Full=C-14 sterol reductase ERG24A; AltName: Full=Ergosterol biosynthetic protein 24A; AltName: Full=Sterol C14-reductase ERG24A [Fusarium graminearum PH-1] Sequence ID: I1RR90.1 Length: 485 Range 1: 102 to 485 Score:253 bits(645), Expect:4e-78, Method:Compositional matrix adjust., Identities:150/390(38%), Positives:215/390(55%), Gaps:60/390(15%) Query 92 PGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVF-GLVTMG-----WLDATVLYDQLGPL 145 P V+G +L G RL YR N ++S FTLAV+ G + G W T + + + Sbjct 102 PAIEVEGTQLSSGGRLKYRFNTLYSSTFTLAVLAAGTIAQGAEFPVW---TFMSENFIQI 158 Query 146 LTVVNIFTFVFAGFLYFWGLNGKQWERP---------TGRPFYDYFMGTALNPRI----- 191 L+ I++++ + F+Y + K + +G YD+F+G LNPRI Sbjct 159 LSANIIYSYLVSTFVYVRSFSVKHGNKENRELAAGGHSGNILYDWFIGRELNPRIEIPLI 218 Query 192 GSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEA 251 G +D+K F E RPGM+ W++MN S A+QY +G VT +L+ Q+ Y+ D + +E A Sbjct 219 GEVDIKEFLELRPGMMGWIIMNCSWCAQQYRNYGFVTDSSILITAVQALYVFDSWWNEPA 278 Query 252 VLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAI 311 +LTT DI + FG ML +GD+VW+P+ Y+LQ +YL H L G+ A++ L G+ I Sbjct 279 ILTTMDITTDGFGMMLAFGDIVWVPYVYSLQTRYLSVHPVSLGPLGLAAMLGLIGLGFYI 338 Query 312 FRGANIQKHHFRRDPN--RIVWGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALS 369 FR AN +K+ FR +PN R+ KYI+TK GS LLT+GWWG++RH+NY GD + + Sbjct 339 FRSANNEKNRFRTNPNDPRV---SHLKYIQTKTGSKLLTTGWWGMSRHINYLGDWIQSWP 395 Query 370 WCLPAAF--------------------------------GSPIPYFHIVYFTILLLHREK 397 +CLP G I YF+I+YF ILL+HRE+ Sbjct 396 YCLPTGLAGYQIMSAGANIEGAYVMHDGREVVQGEAQGWGMLITYFYILYFGILLIHRER 455 Query 398 RDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 RDD C KYG+DW +YRK V RIVP +Y Sbjct 456 RDDEKCHRKYGKDWEEYRKIVRSRIVPGLY 485 >RecName: Full=Delta(14)-sterol reductase; AltName: Full=C-14 sterol reductase; AltName: Full=Sterol C14-reductase [Septoria lycopersici] Sequence ID: O13597.1 Length: 512 Range 1: 119 to 512 Score:236 bits(602), Expect:2e-71, Method:Compositional matrix adjust., Identities:153/398(38%), Positives:208/398(52%), Gaps:66/398(16%) Query 92 PGPTVQGMKLPDGSRLDYRMNGIFSFLFT-LAVVFGLVTMG-----WLDATVLYDQLGPL 145 P V+G +L G RL YR N S + +A G + G W Y QL Sbjct 119 PAHEVEGTELRTGGRLKYRFNACLSAVTIFVACAAGTIVRGPDFQVWTFINRNYIQL--- 175 Query 146 LTVVNIFTFVFAGFLYFWGL-----NGKQWERP----TGRPFYDYFMGTALNPRI----- 191 LTV I + A ++Y N +Q E +G YD++MG LNPRI Sbjct 176 LTVNIIIAYALAIYVYLKSFEVKAGNTEQRELAAGGHSGHILYDWYMGRELNPRITIPFI 235 Query 192 GSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVT------VPMLL-----------V 234 G +D+K F E RPGMI W+L++L+ AAKQY+ +G +T P+LL V Sbjct 236 GEVDIKSFMELRPGMIGWVLLDLAFAAKQYKSYGYITDSMRKWTPLLLGIHVLTIHPVIV 295 Query 235 VGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLP 294 + QS Y+ D E A+LTT D+ + FG+ML +GDLVW+PF Y++QA+YL H L Sbjct 296 IISQSVYVFDALYMEPAILTTMDLTTDGFGFMLSFGDLVWVPFIYSIQAKYLSVHPVALG 355 Query 295 VWGIIAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGI 354 + I+ + GY IFR N K+ FR +PN KYI+T GS LLT+GWWG Sbjct 356 PLYVALILTIQATGYYIFRATNNDKNIFRTNPNDPKVAH-LKYIETGTGSRLLTTGWWGT 414 Query 355 ARHMNYFGDLMIALSWCLPA-------------------------AFGSPIPYFHIVYFT 389 ARH+NY GD +++ S+CLP G PI YF+++YF Sbjct 415 ARHINYLGDWLMSWSYCLPTLAAGYKLTPTILFENSRLVSTDGMKGAGIPITYFYMLYFA 474 Query 390 ILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKIY 427 ILL+HRE+RD+A C KYG W +Y + V WRI+P +Y Sbjct 475 ILLIHRERRDEAKCRRKYGAHWEKYCQIVRWRILPGVY 512 >RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Protein DWARF 5; AltName: Full=Sterol Delta(7)-reductase [Arabidopsis thaliana] Sequence ID: Q9LDU6.1 Length: 432 Range 1: 14 to 432 Score:228 bits(582), Expect:2e-69, Method:Compositional matrix adjust., Identities:142/422(34%), Positives:215/422(50%), Gaps:21/422(4%) Query 24 SWLVLMIALPPLVYYLWICVTYYQGELVFT------SDAAAWRRFWSHVAPPTWHAAGLY 77 S L L+ PP V LW + + G + T + W W Y Sbjct 14 SMLSLLAFCPPFVILLWYTMVHQDGSVTQTFGFFWENGVQGLINIWPRPTLIAWKIIFCY 73 Query 78 AAWFLGQAALQVWAPGPTVQGMKLPDGSRLDYRMNGIFSFLFTLAVVFGLVTMGWLDATV 137 A+ +A LQ+ PG V+G P G+R Y+ NG+ ++ TLA GL G + + Sbjct 74 GAF---EAILQLLLPGKRVEGPISPAGNRPVYKANGLAAYFVTLATYLGLWWFGIFNPAI 130 Query 138 LYDQLGPLLTVVNIFTFVFAGFLYFWG--LNGKQWERPTGRPFYDYFMGTALNPRIG-SL 194 +YD LG + + + +F+F LY G G D++ G L PRIG S Sbjct 131 VYDHLGEIFSALIFGSFIFCVLLYIKGHVAPSSSDSGSCGNLIIDFYWGMELYPRIGKSF 190 Query 195 DLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLT 254 D+K+F R GM+ W ++ ++ KQYE++G V+ ML+ Y+ +F E Sbjct 191 DIKVFTNCRFGMMSWAVLAVTYCIKQYEINGKVSDSMLVNTILMLVYVTKFFWWEAGYWN 250 Query 255 TWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRG 314 T DI H++ G+ +CWG LVW+P YT YLV+H +L I I+ + I Sbjct 251 TMDIAHDRAGFYICWGCLVWVPSVYTSPGMYLVNHPVELGTQLAIYILVAGILCIYINYD 310 Query 315 ANIQKHHFRRDPNR-IVWGK-PAKYIKT-------KQGSLLLTSGWWGIARHMNYFGDLM 365 + Q+ FRR + +VWG+ P+K + + + SLLLTSGWWG+ARH +Y +++ Sbjct 311 CDRQRQEFRRTNGKCLVWGRAPSKIVASYTTTSGETKTSLLLTSGWWGLARHFHYVPEIL 370 Query 366 IALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRIVPK 425 A W +PA F + + YF++++ T+LL R KRDD C +KYG+ W Y +KV +RI+P Sbjct 371 SAFFWTVPALFDNFLAYFYVIFLTLLLFDRAKRDDDRCRSKYGKYWKLYCEKVKYRIIPG 430 Query 426 IY 427 IY Sbjct 431 IY 432 >RecName: Full=Delta(14)-sterol reductase ERG24B; AltName: Full=C-14 sterol reductase ERG24B; AltName: Full=Ergosterol biosynthetic protein 24B; AltName: Full=Sterol C14-reductase ERG24B [Fusarium graminearum PH-1] Sequence ID: I1RF79.1 Length: 481 Range 1: 3 to 481 Score:223 bits(568), Expect:1e-66, Method:Compositional matrix adjust., Identities:154/485(32%), Positives:237/485(48%), Gaps:74/485(15%) Query 11 AVDAVRQKYGFGFSWLVLMIALPPLVYYLWICVTYYQG---ELVFTSDAAAWRRFWSHVA 67 A D+ R ++G ++ LP L+ L++ G + +W + S + Sbjct 3 APDSPRYEFGGPLGATGIVFGLPILMQVLYLGCNDVSGCPAPALLDPKTLSWAKLKSQIP 62 Query 68 PPTWHAAG---------LYAAWFLGQAALQVWAPGPTVQGMKLPD-GSRLDYRMNGIFSF 117 P +G L+A +FL ++ P V G KL + G L+YR N SF Sbjct 63 WPQEGLSGFMSWEVTRWLFAYYFLSLMLYRI-MPAQIVLGTKLRESGKPLEYRFN---SF 118 Query 118 LFTLAVVFGLVTMGWLDA------TVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWE 171 T+ + G ++ T + D LLT + T++ + + Y + K Sbjct 119 SATVVQLTGCAIGTYIYGANFPVWTWITDHYIQLLTTSTVLTYIISIWTYLRSFSIKPGN 178 Query 172 RP---------TGRPFYDYFMGTALNPRI-----GSLDLKLFCEARPGMIFWLLMNLSMA 217 TGR YDYF+G LNPR+ G +D+K + E RPG+ W+L+N S Sbjct 179 PELREVAVGGRTGRVIYDYFIGRELNPRVTLPFFGEIDIKAWLEMRPGLTGWILLNCSFI 238 Query 218 AKQYELHGTVTVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPF 277 AKQY +G V+ ++++ Q++Y+++ E +L+ DI + G+ML WGD+VW+PF Sbjct 239 AKQYRTYGFVSDSIVVIALIQAYYVLEGQYSEAGLLSMMDITSDGLGFMLTWGDIVWVPF 298 Query 278 TYTLQAQYL-VHHTHDLPVWGIIAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAK 336 Y+ Q +YL V+ H P+ G+ AI + G IFR +N QK FR+DPN + Sbjct 299 LYSTQCRYLSVYPVHLGPI-GVGAIGTVFCIGLYIFRSSNNQKALFRKDPNNPAFAN-MT 356 Query 337 YIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLP----------------------- 373 YI+TK+G+ LLT GWWG+ARH+NY GD + +L +CLP Sbjct 357 YIQTKRGTKLLTGGWWGMARHVNYLGDWIQSLPFCLPTKAAGYVILPAGTAVAGAEVAKM 416 Query 374 -----------AAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRKKVPWRI 422 A +G Y + +F LL+HRE+RDD C KYG+DW +Y+ KV WR+ Sbjct 417 LDGRLVTPGDAAPWGMLFTYLYSAWFGFLLIHRERRDDYACSEKYGKDWEEYKNKVRWRV 476 Query 423 VPKIY 427 +P +Y Sbjct 477 LPGVY 481 >RecName: Full=Delta(24(24(1)))-sterol reductase erg4B; AltName: Full=C-24(28) sterol reductase erg4B; AltName: Full=Ergosterol biosynthesis protein 4B; AltName: Full=Sterol Delta(24(28))-reductase erg4V [Aspergillus fumigatus Af293] Sequence ID: Q4WJ59.2 Length: 571 Range 1: 132 to 568 Score:218 bits(555), Expect:5e-64, Method:Compositional matrix adjust., Identities:147/437(34%), Positives:222/437(50%), Gaps:27/437(6%) Query 18 KYGFGFSW--LVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWRRFWSHV-------AP 68 ++ FG SW L +MI P L+YY+WI YY G+ S+ + F +H+ A Sbjct 132 EFEFGGSWGVLSMMIGFPLLMYYMWIGAVYYDGKFPRPSEGQSMSEFLAHMGHLVCEGAY 191 Query 69 PTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLP--DGSRLDYRMNGIFSFLFTLAVVFG 126 P+ A +Y +F+ +A V PG TV G LP G +L Y +G++SF ++A+ Sbjct 192 PSLRAWIIYWVFFIFEALCYVLLPGVTVMGRALPHLGGKQLPYYCSGVWSFYTSIALAGV 251 Query 127 LVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGLNGKQWERPTGRPFYDYFMGTA 186 L G + D+ GPLL+V I F+ + YF L R TG YD+FMG Sbjct 252 LHFTGIFKLYTIIDEFGPLLSVAIISGFLVSFVAYFSALARGAQHRMTGYHIYDFFMGAE 311 Query 187 LNPRI-GSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDY 245 LNPR+ G LD K+F E R ++L AA+QYE++G V+ + ++ Y Sbjct 312 LNPRMFGILDFKMFFEVRLPWFILFFISLGAAARQYEVYGYVSGEVGFLLMAHFLYANAC 371 Query 246 FIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALN 305 EE +++TWD+ +EK+G+ML + +L +P +Y YL H W + +V L Sbjct 372 CKGEECIVSTWDMYYEKWGFMLIFWNLAGVPLSYCHCTIYLASHDPATYRWNRVFLVFLY 431 Query 306 LA---GYAIFRGANIQKHHFRRDPN----------RIVWG--KPAKYIKTKQGSLLLTSG 350 A Y ++ N QK+ FR+ ++ W K K I GS +L G Sbjct 432 AAYLFVYWVWDTTNSQKNRFRQQERGTMVSRKTFPQLPWQTLKNPKTITAADGSKILVDG 491 Query 351 WWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGED 410 W+G AR ++Y DL AL+W L F SP P+F+ ++F ++ HR RD C KYGE Sbjct 492 WYGKARKIHYTCDLYFALNWGLITGFSSPFPWFYPIFFACMITHRALRDIQRCRNKYGEA 551 Query 411 WLQYRKKVPWRIVPKIY 427 W++Y ++VP+ +P Y Sbjct 552 WVEYERQVPYLFIPVSY 568 >RecName: Full=Delta(24(24(1)))-sterol reductase; AltName: Full=C-24(28) sterol reductase; AltName: Full=Staurosporine-supersensitivity protein 1; AltName: Full=Sterol Delta(24(28))-reductase [Schizosaccharomyces pombe 972h-] Sequence ID: P36209.2 Length: 453 Range 1: 11 to 453 Score:213 bits(542), Expect:3e-63, Method:Compositional matrix adjust., Identities:143/443(32%), Positives:219/443(49%), Gaps:32/443(7%) Query 17 QKYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSD--AAAWRRFWSHV-------A 67 +++G L +M P L+YYLW C + + + A ++ F+ + A Sbjct 11 REFGGAKGALAIMTGFPCLMYYLWACSKFNDSQFIKPESFTIAGFQNFFRTLGHYIYVGA 70 Query 68 PPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLP--DGSRLDYRMNGIFSFLFTLAVVF 125 PT +A ++ ++ + QA + + PG QG+ L + RL Y N I+SF T+ ++ Sbjct 71 YPTRYAFLVFWSFCIVQAVMYLTLPGVRTQGLPLKHRNNERLPYLCNAIWSFYTTIVILA 130 Query 126 GLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL--NGKQWERP---TGRPFYD 180 L T D GPL++V I FV LY L + +++P +G P YD Sbjct 131 VLHVTHVFPITTFIDMFGPLMSVAIITAFVCTFVLYTGTLLFGDRLFDKPHRLSGNPIYD 190 Query 181 YFMGTALNPRIGSL-DLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQS 239 FMG LNPR+G L D K+F E R +++ A +QYE +GTV+ +L V Sbjct 191 AFMGACLNPRLGKLLDFKMFFEVRIPWFILFFISVGAAVRQYETYGTVSPQVLFVCLGHY 250 Query 240 FYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGI- 298 Y E+ ++ TWD+ +EKFG+ML + ++ +PFTY+ YL H + W Sbjct 251 LYANACSKGEQLIVPTWDMAYEKFGFMLIFWNMAGVPFTYSHCTLYLFSHDPSVYNWSTQ 310 Query 299 --IAIVALNLAGYAIFRGANIQKHHFRR-----DPNRIVWG-------KPAKYIKTKQGS 344 I L L Y IF N QK+HFR + +R + K +I+ G Sbjct 311 YTTGIYVLLLCCYYIFDTCNGQKNHFRNQIYGTEVHRKTFPQLPWLIIKNPTFIRCANGG 370 Query 345 LLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCL 404 LLTSGW+ AR ++Y D +LSW L F SP+PYF+ +F ++L+HR RD C Sbjct 371 TLLTSGWYRYARKIHYTADFFQSLSWALITGFQSPLPYFYPCFFFVVLVHRVSRDIKKCK 430 Query 405 AKYGEDWLQYRKKVPWRIVPKIY 427 AKYG D+ +Y + P+ +P I+ Sbjct 431 AKYGADFDEYCRICPYLFIPYIF 453 >RecName: Full=Delta(24(24(1)))-sterol reductase; AltName: Full=C-24(28) sterol reductase; AltName: Full=Sterol Delta(24(28))-reductase [Fusarium graminearum PH-1] Sequence ID: I1RZZ3.1 Length: 596 Range 1: 163 to 595 Score:207 bits(528), Expect:7e-60, Method:Compositional matrix adjust., Identities:145/435(33%), Positives:225/435(51%), Gaps:28/435(6%) Query 18 KYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWRRFWSHVAPPTWHAA--- 74 ++G F +M P L++Y+WI TYY G+ ++ +W F +H+A + A Sbjct 163 EFGGSFGTAAMMTLFPVLMWYMWIGATYYDGKFPSRTEGQSWSEFGAHLANLVYTGAFPR 222 Query 75 ----GLYAAWFLGQAALQVWAPGPTVQGMKLPD--GSRLDYRMNGIFSFLFTLAVVFGLV 128 Y ++ + + A PG G LP G +L Y N +S TLA + GL Sbjct 223 LQVWAWYWSYLIVEGAFYCLLPGVWGYGKPLPHEGGKQLPYYCNAYWSLYTTLACLAGLH 282 Query 129 TMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL-NGKQWERPTGRPFYDYFMGTAL 187 G D+ GPLL+V + F+ + YF L GKQ R TG P YD+FMG L Sbjct 283 YSGIWPLYTAVDEFGPLLSVAILSGFLVSIVAYFSALWRGKQ-HRMTGYPIYDFFMGAEL 341 Query 188 NPRI-GSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYLIDYF 246 NPR+ G LD K+F E R L+++L AA+Q+E +G V+ + +V Y Sbjct 342 NPRMFGILDFKMFFEVRMPWYILLILSLGTAARQHEQYGYVSGEVWFLVMAHFLYANACA 401 Query 247 IHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVW--GIIAIVAL 304 EE ++TTWD+ +EK+G+ML + +L +P +Y YL +H D+ W GI+A + + Sbjct 402 KGEELIITTWDMYYEKWGFMLIFWNLAGVPLSYCHCTIYLANHHPDVYRWNRGILAAMFV 461 Query 305 N-LAGYAIFRGANIQKHHFRR-DPNRIVWGKP-----------AKYIKTKQGSLLLTSGW 351 L Y ++ N QK+ FR + ++V K I + QG++L+ GW Sbjct 462 GYLFWYWVWDSCNSQKNRFRAMEKGKLVLRNTFPQVPWQTIHNPKTIVSPQGTILV-DGW 520 Query 352 WGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLAKYGEDW 411 +G+AR ++Y D+ A+SW L F SP P+F+ V+F ++ HR RD C KYG+ W Sbjct 521 YGLARKIHYTADVWFAVSWGLITGFESPFPWFYPVFFCCMIAHRAARDIHRCRRKYGDAW 580 Query 412 LQYRKKVPWRIVPKI 426 L+Y ++VP+ +P + Sbjct 581 LEYERRVPYLFIPYV 595 >RecName: Full=Delta(24(24(1)))-sterol reductase ERG4; AltName: Full=C-24(28) sterol reductase ERG4; AltName: Full=Ergosterol biosynthetic protein 4; AltName: Full=Sterol Delta(24(28))-reductase ERG4 [Saccharomyces cerevisiae S288C] Sequence ID: P25340.2 Length: 473 Range 1: 34 to 473 Score:194 bits(492), Expect:1e-55, Method:Compositional matrix adjust., Identities:137/442(31%), Positives:211/442(47%), Gaps:29/442(6%) Query 13 DAVRQKYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWRRFWSHV------ 66 + + ++G + ++I P L+YY+WIC +Y G++ +W F H+ Sbjct 34 NEIEYEFGGTTGVIGMLIGFPLLMYYMWICAEFYHGKVALPKAGESWMHFIKHLYQLVLE 93 Query 67 -APPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLP--DGSRLDYRMNGIFSFLFTLAV 123 P + ++ +++ Q PG +G L G +L Y N +++ T + Sbjct 94 NGIPEKYDWTIFLTFWVFQIIFYYTLPGIWTKGQPLSHLKGKQLPYFCNAMWTLYVTTTL 153 Query 124 VFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL-NGKQWERPTGRPFYDYF 182 V L V+ D+ G ++T I F F+ LY W L + R TG YD+F Sbjct 154 VLVLHFTNLFRLYVIIDRFGRIMTCAIISGFAFSIILYLWTLFISHDYHRMTGNHLYDFF 213 Query 183 MGTALNPRIGSLDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVTVPMLLVVGFQSFYL 242 MG LNPR G LDLK+F E R + L KQ+E +G VT + +V+ Y Sbjct 214 MGAPLNPRWGILDLKMFFEVRLPWFTLYFITLGACLKQWETYGYVTPQLGVVMLAHWLYA 273 Query 243 IDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIV 302 EE ++ TWD+ +EKFG+ML + ++ +P+TY YL +H W + V Sbjct 274 NACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHCTLYLYYHDPSEYHWSTLYNV 333 Query 303 ALN---LAGYAIFRGANIQKHHFRRD--------------PNRIVWGKPAKYIKTKQGSL 345 +L L Y F AN QK+ FR+ P +I+ K KY+ T GS Sbjct 334 SLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTFPFLPYQIL--KNPKYMVTSNGSY 391 Query 346 LLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLLHREKRDDAMCLA 405 LL GW+ +AR ++Y D +L W L F S P+F V+F ++L+HR RD A C Sbjct 392 LLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFFPVFFLVVLIHRAFRDQAKCKR 451 Query 406 KYGEDWLQYRKKVPWRIVPKIY 427 KYG+DW +Y K P+ +P ++ Sbjct 452 KYGKDWDEYCKHCPYVFIPYVF 473 >RecName: Full=Delta(24(24(1)))-sterol reductase; AltName: Full=C-24(28) sterol reductase; AltName: Full=Ergosterol biosynthetic protein 4; AltName: Full=Sterol Delta(24(28))-reductase [Candida albicans SC5314] Sequence ID: A0A1D8PJ25.1 Length: 469 Range 1: 17 to 468 Score:191 bits(486), Expect:7e-55, Method:Compositional matrix adjust., Identities:140/453(31%), Positives:214/453(47%), Gaps:28/453(6%) Query 1 MSEQESRDNAAVDAVRQKYGFGFSWLVLMIALPPLVYYLWICVTYYQGELVFTSDAAAWR 60 + ESR D + ++G L +MI P L++Y+WI +Y G+ S+ +W+ Sbjct 17 VGSDESR-YIPKDQIEYEFGGPIGALGMMIGFPLLMWYMWISAQFYNGQFALPSEGQSWK 75 Query 61 RF--------WSHVAPPTWHAAGLYAAWFLGQAALQVWAPGPTVQGMKLP--DGSRLDYR 110 F W P++ + + L QA V PG +G L + +L Y Sbjct 76 DFIIDDLFSKWVEYGIPSFGNWAFFTGFILIQALFYVTLPGVWTKGQPLTHLNNKQLPYF 135 Query 111 MNGIFSFLFTLAVVFGLVTMGWLDATVLYDQLGPLLTVVNIFTFVFAGFLYFWGL-NGKQ 169 N I+SF ++ + L G L + D +G ++T + + LY + Sbjct 136 CNAIWSFYTSIVLSLVLHFTGVLPVYYMLDNVGGIMTTAIFYGISLSIILYLICIFVTGD 195 Query 170 WERPTGRPFYDYFMGTALNPRIGS-LDLKLFCEARPGMIFWLLMNLSMAAKQYELHGTVT 228 + R TG YD FMG LNPRIG LDLK+F E R ++ + KQYE +G VT Sbjct 196 YHRMTGNHIYDMFMGAPLNPRIGKYLDLKMFFEVRIPWFILFFLSFGLCFKQYETYGYVT 255 Query 229 VPMLLVVGFQSFYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVH 288 ++ Y EE ++ TWD+ +EKFG+ML + ++ +PF+Y Y+ + Sbjct 256 PQACFMLYAHWLYANACAKGEELIVPTWDMAYEKFGFMLLFWNIAGVPFSYCQCILYIAY 315 Query 289 HTHDLPVWGI---IAIVALNLAGYAIFRGANIQKHHFRRD---PNRIVWGKP-------- 334 ++ W I + + L Y F N QK+ FRR +++ P Sbjct 316 QEPEVYQWSIGYNVFLFVLITIAYYFFDTGNRQKNSFRRSVAGNSQLRKTFPYLPYSDLV 375 Query 335 -AKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAAFGSPIPYFHIVYFTILLL 393 KYIK GSLLLT GW+ AR M+Y D + L+W L FGSP P+F ++F I+L+ Sbjct 376 NPKYIKCANGSLLLTDGWYVYARKMHYTADYIQTLTWALMCGFGSPFPWFFPIFFFIVLV 435 Query 394 HREKRDDAMCLAKYGEDWLQYRKKVPWRIVPKI 426 HR RD C KYG+DW +Y + P+ +P + Sbjct 436 HRGYRDQRKCAKKYGKDWDRYLEACPYMFIPYV 468 >RecName: Full=Lamin-B receptor; AltName: Full=dLBR [Drosophila melanogaster] Sequence ID: Q8MLV1.1 Length: 741 Range 1: 554 to 741 Score:66.2 bits(160), Expect:2e-10, Method:Compositional matrix adjust., Identities:55/191(29%), Positives:90/191(47%), Gaps:6/191(3%) Query 240 FYLIDYFIHEEAVLTTWDIKHEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVW-GI 298 FY++D I E + ++++++HE +G +L P+ T +Y + W Sbjct 554 FYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYFYEQRVPISCWYAP 612 Query 299 IAIVALNLAGYAIFRGANIQKHHFRRDPNRIVWGKPAKYIKTKQGSLLLTSGWWGIARHM 358 +A+ AL G + R + K+ +R + ++ + I T QGS LL SG WG R Sbjct 613 LAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFAN-IETIHTYQGSRLLLSGMWGWVRQP 671 Query 359 NYFGDLMIALSWCLPAAFGSPI--PYFHIVYFTILLLHREKRDDAMCLAKYGEDWLQYRK 416 NY GD+ +AL P P + +LLLHR R +A A+Y W +Y Sbjct 672 NYLGDI-VALLALAAPMALRPAWPPVLGLSLIILLLLHRATRANARNQARYHSSWQRYST 730 Query 417 KVPWRIVPKIY 427 +V I+P++Y Sbjct 731 QVRSYILPRVY 741