PMID- 6775685
OWN - NLM
STAT- MEDLINE
DA  - 19810116
DCOM- 19810116
LR  - 20061115
IS  - 0306-5456 (Print)
IS  - 0306-5456 (Linking)
VI  - 87
IP  - 9
DP  - 1980 Sep
TI  - Establishing full-term human pregnancies using cleaving embryos grown in vitro.
PG  - 737-56
AB  - The establishment of human pregnancies by the use of fertilization in vitro and
      placing cleaving embryos into the uterus is described. Preovulatory oocytes were 
      aspirated at laparoscopy from the ovaries of patients soon after the beginning of
      the mid-cycle surge of luteinizing hormone (LH) during the natural cycle. The LH 
      surge was identified by assaying 3-hourly samples of urine, and measurements of
      oestrogens in 24-hour samples were used to assess follicular growth. The surge of
      LH was identified in 68 patients and it showed a diurnal rhythm. Preovulatory
      oocytes were aspirated from most of the patients. Fertilization and cleavage
      occurred in 34 instances, and 32 embryos were put into the mother via the
      cervical canal. Four patients became pregnant. There were indications that a
      diurnal rhythm played a role in establishing cleaving embryos, each of the four
      pregnancies occurring when the embryos were placed in late evening. Each of the
      pregnancies resulted from oocytes which were aspirated from their follicles 24
      hours or longer after the LH surge began. Details are given of three abortive
      pregnancies in patients given gonadotrophins to stimulate the maturation of of
      oocytes used for fertilization in vitro.
FAU - Edwards, R G
AU  - Edwards RG
FAU - Steptoe, P C
AU  - Steptoe PC
FAU - Purdy, J M
AU  - Purdy JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - ENGLAND
TA  - Br J Obstet Gynaecol
JT  - British journal of obstetrics and gynaecology
JID - 7503752
RN  - 0 (Chorionic Gonadotropin)
RN  - 0 (Hormones)
RN  - 61489-71-2 (Menotropins)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - AIM
SB  - IM
MH  - Chorionic Gonadotropin/therapeutic use
MH  - Circadian Rhythm
MH  - Cleavage Stage, Ovum/physiology
MH  - Embryo Transfer/*methods
MH  - Female
MH  - Fertilization in Vitro/*methods
MH  - Hormones/metabolism
MH  - Humans
MH  - Luteinizing Hormone/secretion
MH  - Menotropins/therapeutic use
MH  - Menstruation/drug effects
MH  - Oocytes/physiology
MH  - *Pregnancy
MH  - Suction
EDAT- 1980/09/01
MHDA- 1980/09/01 00:01
CRDT- 1980/09/01 00:00
PST - ppublish
SO  - Br J Obstet Gynaecol. 1980 Sep;87(9):737-56.