1: Wu S, Huang R, Xu L, Yan G, Wang Q. Improved hydrogen production with
expression of hemH and lba genes in chloroplast of Chlamydomonas reinhardtii. J
Biotechnol. 2010 Feb 6. [Epub ahead of print] PubMed PMID: 20138927.

2: Whatley SD, Mason NG, Holme SA, Anstey AV, Elder GH, Badminton MN. Molecular
epidemiology of erythropoietic protoporphyria in the United Kingdom. Br J
Dermatol. 2010 Jan 22. [Epub ahead of print] PubMed PMID: 20105171.

3: Hanneken S, Siegesmund M, Bolsen K, Gardlo K, Neumann NJ. The prognostic value
of cord blood analysis in erythropoietic protoporphyria: the 'Duesseldorf Cord
Blood Study'. Photodermatol Photoimmunol Photomed. 2010 Feb;26(1):7-9. PubMed
PMID: 20070832.

4: Crooks DR, Ghosh MC, Haller RG, Tong WH, Rouault TA. Posttranslational
stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron
availability and intact iron-sulfur cluster assembly machinery. Blood. 2010 Jan
28;115(4):860-9. Epub 2009 Nov 25. PubMed PMID: 19965627; PubMed Central PMCID:
PMC2815515.

5: Inoue K, Karashima T, Kamada M, Shuin T, Kurabayashi A, Furihata M, Fujita H, 
Utsumi K, Sasaki J. Regulation of 5-aminolevulinic acid-mediated protoporphyrin
IX accumulation in human urothelial carcinomas. Pathobiology. 2009;76(6):303-14. 
Epub 2009 Nov 30. PubMed PMID: 19955842.

6: Apchelimov AA, Ezhova TA, Shestakov SV. [Evolution aspects of intraspecific
polymorphysm of Arabidopsis thaliana genes coding subunit I of Mg-chelatase
complex]. Mol Biol (Mosk). 2009 Sep-Oct;43(5):931-6. Russian. PubMed PMID:
19899639.

7: Ma J, Xiao S, An J, Wang X, Xu Q, Dong Y, Feng Y, Wang J. A novel splicing
mutation and haplotype analysis of the FECH gene in a Chinese family with
erythropoietic protoporphyria. J Eur Acad Dermatol Venereol. 2009 Nov 2. [Epub
ahead of print] PubMed PMID: 19888946.

8: Wang Y, Shen Y, Ryde U. QM/MM study of the insertion of metal ion into
protoporphyrin IX by ferrochelatase. J Inorg Biochem. 2009 Dec;103(12):1680-6.
Epub 2009 Sep 24. PubMed PMID: 19850353.

9: Huang ML, Becker EM, Whitnall M, Rahmanto YS, Ponka P, Richardson DR.
Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia
by analysis of a mouse mutant. Proc Natl Acad Sci U S A. 2009 Sep
22;106(38):16381-6. Epub 2009 Sep 4. PubMed PMID: 19805308; PubMed Central PMCID:
PMC2752539.

10: Feuerstein T, Schauder A, Malik Z. Silencing of ALA dehydratase affects
ALA-photodynamic therapy efficacy in K562 erythroleukemic cells. Photochem
Photobiol Sci. 2009 Oct;8(10):1461-6. Epub 2009 Aug 17. PubMed PMID: 19789817.

11: Davidson RE, Chesters CJ, Reid JD. Metal ion selectivity and substrate
inhibition in the metal ion chelation catalyzed by human ferrochelatase. J Biol
Chem. 2009 Dec 4;284(49):33795-9. Epub 2009 Sep 19. PubMed PMID: 19767646; PubMed
Central PMCID: PMC2788750.

12: Lecha M, Puy H, Deybach JC. Erythropoietic protoporphyria. Orphanet J Rare
Dis. 2009 Sep 10;4:19. Review. PubMed PMID: 19744342; PubMed Central PMCID:
PMC2747912.

13: Amo T, Kawanishi N, Uchida M, Fujita H, Oyanagi E, Utsumi T, Ogino T, Inoue
K, Shuin T, Utsumi K, Sasaki J. Mechanism of cell death by 5-aminolevulinic
acid-based photodynamic action and its enhancement by ferrochelatase inhibitors
in human histiocytic lymphoma cell line U937. Cell Biochem Funct. 2009
Dec;27(8):503-15. PubMed PMID: 19735078.

14: Parolari G, Benedini R, Toscani T. Color formation in nitrite-free dried hams
as related to Zn-protoporphyrin IX and Zn-chelatase activity. J Food Sci. 2009
Aug;74(6):C413-8. PubMed PMID: 19723176.

15: Taketani T, Kanai R, Fukuda S, Uchida Y, Yasuda K, Mishima S, Suyama T,
Kodama R, Yoshino I, Kunishi H, Yamaguchi S, Masuda J. Pure red cell precursor
toxicity by linezolid in a pediatric case. J Pediatr Hematol Oncol. 2009
Sep;31(9):684-6. PubMed PMID: 19707157.

16: Medlock AE, Carter M, Dailey TA, Dailey HA, Lanzilotta WN. Product release
rather than chelation determines metal specificity for ferrochelatase. J Mol
Biol. 2009 Oct 23;393(2):308-19. Epub 2009 Aug 22. PubMed PMID: 19703464; PubMed 
Central PMCID: PMC2771925.

17: Parera VE, Koole RH, Minderman G, Edixhoven A, Rossetti MV, Batlle A, de
Rooij FW. Novel null-allele mutations and genotype-phenotype correlation in
argentinean patients with erythropoietic protoporphyria. Mol Med. 2009
Nov-Dec;15(11-12):425-31. Epub 2009 Aug 12. PubMed PMID: 19693296; PubMed Central
PMCID: PMC2729100.

18: Sakaino M, Ishigaki M, Ohgari Y, Kitajima S, Masaki R, Yamamoto A, Taketani
S. Dual mitochondrial localization and different roles of the reversible reaction
of mammalian ferrochelatase. FEBS J. 2009 Oct;276(19):5559-70. Epub 2009 Aug 19. 
PubMed PMID: 19691493.

19: Shalygo N, Czarnecki O, Peter E, Grimm B. Expression of chlorophyll synthase 
is also involved in feedback-control of chlorophyll biosynthesis. Plant Mol Biol.
2009 Nov;71(4-5):425-36. Epub 2009 Aug 13. PubMed PMID: 19680747.

20: Holme SA, Anstey AV, Whatley SD, Elder GH, Badminton MN. A homozygous
mutation in the ferrochelatase gene underlies erythropoietic protoporphyria
associated with palmar keratoderma--reply. Br J Dermatol. 2009 Oct;161(4):966-7. 
Epub 2009 Aug 10. PubMed PMID: 19673873.

21: Wahlin S, Harper P. Skin ferrochelatase and photosensitivity in mice and man.
J Invest Dermatol. 2010 Feb;130(2):631-3. Epub 2009 Aug 6. PubMed PMID: 19657351.

22: Park SJ, Chun YS, Park KS, Kim SJ, Choi SO, Kim HL, Park JW. Identification
of subdomains in NADPH oxidase-4 critical for the oxygen-dependent regulation of 
TASK-1 K+ channels. Am J Physiol Cell Physiol. 2009 Oct;297(4):C855-64. Epub 2009
Aug 5. PubMed PMID: 19657056.

23: Martinez Mdel C, Afonso SG, Meiss RP, Buzaleh AM, Batlle A. Hepatic damage
and oxidative stress induced by Griseofulvin in mice. Cell Mol Biol
(Noisy-le-grand). 2009 Jul 1;55(2):127-39. PubMed PMID: 19656461.

24: Elder GH, Gouya L, Whatley SD, Puy H, Badminton MN, Deybach JC. The molecular
genetics of erythropoietic protoporphyria. Cell Mol Biol (Noisy-le-grand). 2009
Jul 1;55(2):118-26. PubMed PMID: 19656460.

25: Schimmel RJ, Van Tuyll Van Serooskerke AM, Bladergroen RS, Van Steensel AM,
van Geel M, Pasmans SG, Frank J. Exclusion of ferrochelatase gene mutations in
patients with seasonal palmoplantar keratoderma. Cell Mol Biol (Noisy-le-grand). 
2009 Jul 1;55(2):111-7. PubMed PMID: 19656459.

26: Barman J, Schneider-Yin X, Mamet R, Schoenfeld N, Minder EI. Variations in
the length of poly-C and poly-T tracts in intron 3 of the human ferrochelatase
gene. Cell Mol Biol (Noisy-le-grand). 2009 Jul 1;55(2):102-10. PubMed PMID:
19656458.

27: Wu B, Novelli J, Foster J, Vaisvila R, Conway L, Ingram J, Ganatra M, Rao AU,
Hamza I, Slatko B. The heme biosynthetic pathway of the obligate Wolbachia
endosymbiont of Brugia malayi as a potential anti-filarial drug target. PLoS Negl
Trop Dis. 2009 Jul 14;3(7):e475. PubMed PMID: 19597542; PubMed Central PMCID:
PMC2703803.

28: Szefczyk B, Cordeiro MN, Franco R, Gomes JA. Molecular dynamics simulations
of mouse ferrochelatase variants: what distorts and orientates the porphyrin? J
Biol Inorg Chem. 2009 Sep;14(7):1119-28. Epub 2009 Jun 20. PubMed PMID: 19543923.

29: Nagaraj VA, Prasad D, Rangarajan PN, Padmanaban G. Mitochondrial localization
of functional ferrochelatase from Plasmodium falciparum. Mol Biochem Parasitol.
2009 Nov;168(1):109-12. Epub 2009 Jun 10. PubMed PMID: 19523497.

30: Seguin A, Bayot A, Dancis A, Rogowska-Wrzesinska A, Auchère F, Camadro JM,
Bulteau AL, Lesuisse E. Overexpression of the yeast frataxin homolog (Yfh1):
contrasting effects on iron-sulfur cluster assembly, heme synthesis and
resistance to oxidative stress. Mitochondrion. 2009 Apr;9(2):130-8. Epub 2009 Jan
22. PubMed PMID: 19460301.

31: Anand S, Honari G, Hasan T, Elson P, Maytin EV. Low-dose methotrexate
enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in
vitro and in vivo. Clin Cancer Res. 2009 May 15;15(10):3333-43. Epub 2009 May 15.
PubMed PMID: 19447864; PubMed Central PMCID: PMC2744072.

32: Schneider-Yin X, Harms J, Minder EI. Porphyria in Switzerland, 15 years
experience. Swiss Med Wkly. 2009 Apr 4;139(13-14):198-206. PubMed PMID: 19350426.

33: Miyake M, Ishii M, Kawashima K, Kodama T, Sugano K, Fujimoto K, Hirao Y.
siRNA-mediated knockdown of the heme synthesis and degradation pathways:
modulation of treatment effect of 5-aminolevulinic acid-based photodynamic
therapy in urothelial cancer cell lines. Photochem Photobiol. 2009
Jul-Aug;85(4):1020-7. Epub 2009 Mar 20. PubMed PMID: 19320847.

34: Méndez M, Poblete-Gutiérrez P, Morán-Jiménez MJ, Rodriguez ME, Garrido-Astray
MC, Fontanellas A, Frank J, de Salamanca RE. A homozygous mutation in the
ferrochelatase gene underlies erythropoietic protoporphyria associated with
palmar keratoderma. Br J Dermatol. 2009 Jun;160(6):1330-4. Epub 2009 Mar 9.
PubMed PMID: 19298273.

35: Delaby C, Lyoumi S, Ducamp S, Martin-Schmitt C, Gouya L, Deybach JC, Beaumont
C, Puy H. Excessive erythrocyte PPIX influences the hematologic status and iron
metabolism in patients with dominant erythropoietic protoporphyria. Cell Mol Biol
(Noisy-le-grand). 2009 Feb 16;55(1):45-52. PubMed PMID: 19268001.

36: Buzaleh AM, Morán-Jiménez MJ, Garcia-Bravo M, Sampedro A, Batlle AM, Enriquez
de Salamanca R, Fontanellas A. Induction of hepatic aminolevulinate acid
synthetase activity by isoflurane in a genetic model for erythropoietic
protoporphyria. Cell Mol Biol (Noisy-le-grand). 2009 Feb 16;55(1):38-44. PubMed
PMID: 19268000.

37: Lobo SA, Brindley A, Warren MJ, Saraiva LM. Functional characterization of
the early steps of tetrapyrrole biosynthesis and modification in Desulfovibrio
vulgaris Hildenborough. Biochem J. 2009 May 13;420(2):317-25. PubMed PMID:
19267692.

38: Sakaino M, Kataoka T, Taketani S. Post-transcriptional regulation of the
expression of ferrochelatase by its variant mRNA. J Biochem. 2009
Jun;145(6):733-8. Epub 2009 Feb 27. PubMed PMID: 19251765.

39: Sperl J, Procházková J, Martásek P, Subhanová I, Franková S, Trunecka P,
Jirsa M. N-acetyl cysteine averted liver transplantation in a patient with liver 
failure caused by erythropoietic protoporphyria. Liver Transpl. 2009
Mar;15(3):352-4. PubMed PMID: 19243001.

40: Shi J, Mei W, Yang J. Heme metabolism enzymes are dynamically expressed
during Xenopus embryonic development. Biocell. 2008 Dec;32(3):259-63. PubMed
PMID: 19181189.

41: Lau KC, Lam CW. Automated imaging of circulating fluorocytes for the
diagnosis of erythropoietic protoporphyria: a pilot study for population
screening. J Med Screen. 2008;15(4):199-203. PubMed PMID: 19106260.

42: Small SK, Puri S, O'Brian MR. Heme-dependent metalloregulation by the iron
response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria.
Biometals. 2009 Feb;22(1):89-97. Epub 2008 Dec 18. PubMed PMID: 19093075; PubMed 
Central PMCID: PMC2659648.

43: Li C, Di Pierro E, Brancaleoni V, Cappellini MD, Steensma DP. A novel large
deletion and three polymorphisms in the FECH gene associated with erythropoietic 
protoporphyria. Clin Chem Lab Med. 2009;47(1):44-6. PubMed PMID: 19055472.

44: Masoumi A, Heinemann IU, Rohde M, Koch M, Jahn M, Jahn D. Complex formation
between protoporphyrinogen IX oxidase and ferrochelatase during haem biosynthesis
in Thermosynechococcus elongatus. Microbiology. 2008 Dec;154(Pt 12):3707-14.
PubMed PMID: 19047738.

45: Lyoumi S, Martin-Schmitt C, Touitou Y, Puy H, Djeridane Y. Melatonin and
environmental lighting regulate ALA-S gene expression and So porphyrin
biosynthesis in the rat harderian gland. Chronobiol Int. 2008 Nov;25(6):851-67.
PubMed PMID: 19005892.

46: Gatta LB, Vitali M, Verardi R, Arosio P, Finazzi D. Inhibition of heme
synthesis alters Amyloid Precursor Protein processing. J Neural Transm. 2009
Jan;116(1):79-88. Epub 2008 Nov 11. PubMed PMID: 19002554.

47: Lau KC, Lam CW, Fong B, Siu TS, Tam S. DNA-based diagnosis of erythropoietic 
protoporphyria in two families and the frequency of a low-expression FECH allele 
in a Chinese population. Clin Chim Acta. 2009 Feb;400(1-2):132-4. Epub 2008 Oct
10. PubMed PMID: 18976643.

48: Brancaleoni V, Di Pierro E, Besana V, Ausenda S, Cappellini MD. Gene symbol: 
FECH. Disease: Porphyria, erythropoietic. Hum Genet. 2008 Oct;124(3):296. PubMed 
PMID: 18846614.

49: Brancaleoni V, Di Pierro E, Besana V, Ausenda S, Cappellini MD. Gene symbol: 
FECH. Disease: Porphyria, erythropoietic. Hum Genet. 2008 Oct;124(3):296. PubMed 
PMID: 18846613.

50: Stephenson PG, Terry MJ. Light signalling pathways regulating the
Mg-chelatase branchpoint of chlorophyll synthesis during de-etiolation in
Arabidopsis thaliana. Photochem Photobiol Sci. 2008 Oct;7(10):1243-52. Epub 2008 
Jul 23. PubMed PMID: 18846290.

51: Nakazawa F, Alev C, Shin M, Nakaya Y, Jakt LM, Sheng G. PBRL, a putative
peripheral benzodiazepine receptor, in primitive erythropoiesis. Gene Expr
Patterns. 2009 Feb;9(2):114-21. Epub 2008 Sep 25. PubMed PMID: 18845277.

52: Holme SA, Whatley SD, Roberts AG, Anstey AV, Elder GH, Ead RD, Stewart MF,
Farr PM, Lewis HM, Davies N, White MI, Ackroyd RS, Badminton MN. Seasonal palmar 
keratoderma in erythropoietic protoporphyria indicates autosomal recessive
inheritance. J Invest Dermatol. 2009 Mar;129(3):599-605. Epub 2008 Sep 11. PubMed
PMID: 18787536.

53: Schneider-Yin X, Mamet R, Minder EI, Schoenfeld N. Biochemical and molecular 
diagnosis of erythropoietic protoporphyria in an Ashkenazi Jewish family. J
Inherit Metab Dis. 2008 Aug 31. [Epub ahead of print] PubMed PMID: 18758989.

54: Caudill JS, Imran H, Porcher JC, Steensma DP. Congenital sideroblastic anemia
associated with germline polymorphisms reducing expression of FECH.
Haematologica. 2008 Oct;93(10):1582-4. Epub 2008 Aug 12. PubMed PMID: 18698088.

55: Okimura Y, Fujita H, Ogino T, Inoue K, Shuin T, Yano H, Yasuda T, Inoue M,
Utsumi K, Sasaki J. Regulation of 5-aminolevulinic acid-dependent protoporphyrin 
IX accumulations in human histiocytic lymphoma U937 cells. Physiol Chem Phys Med 
NMR. 2007;39(1):69-82. PubMed PMID: 18613640.

56: Hunter GA, Sampson MP, Ferreira GC. Metal ion substrate inhibition of
ferrochelatase. J Biol Chem. 2008 Aug 29;283(35):23685-91. Epub 2008 Jul 1.
PubMed PMID: 18593702.

57: Moon J, Zhu L, Shen H, Huq E. PIF1 directly and indirectly regulates
chlorophyll biosynthesis to optimize the greening process in Arabidopsis. Proc
Natl Acad Sci U S A. 2008 Jul 8;105(27):9433-8. Epub 2008 Jun 30. PubMed PMID:
18591656; PubMed Central PMCID: PMC2453699.

58: Zhang F, Lu L, Qian X, Pu LY, Li GQ, Wang XH. Liver transplantation for
erythropoietic protoporphyria with hepatic failure: a case report. Transplant
Proc. 2008 Jun;40(5):1774-6. PubMed PMID: 18589193.

59: Parker M, Corrigall AV, Hift RJ, Meissner PN. Molecular characterization of
erythropoietic protoporphyria in South Africa. Br J Dermatol. 2008
Jul;159(1):182-91. Epub 2008 Jul 1. PubMed PMID: 18460026.

60: Karlberg T, Hansson MD, Yengo RK, Johansson R, Thorvaldsen HO, Ferreira GC,
Hansson M, Al-Karadaghi S. Porphyrin binding and distortion and substrate
specificity in the ferrochelatase reaction: the role of active site residues. J
Mol Biol. 2008 May 16;378(5):1074-83. Epub 2008 Mar 28. PubMed PMID: 18423489.

61: Dam C, Bathum L, Sommerlund M, Bygum A. [Erythropoietic protoporphyria. A
rare inherited metabolic disorder with skin symptoms.]. Ugeskr Laeger. 2008 Jan
28;170(5):352. Danish. PubMed PMID: 18252165.

62: Sobotka R, McLean S, Zuberova M, Hunter CN, Tichy M. The C-terminal extension
of ferrochelatase is critical for enzyme activity and for functioning of the
tetrapyrrole pathway in Synechocystis strain PCC 6803. J Bacteriol. 2008
Mar;190(6):2086-95. Epub 2008 Jan 11. PubMed PMID: 18192382; PubMed Central
PMCID: PMC2258870.

63: Bloomer J, Wang Y, Chen D. Level of Expression of the Nonmutant
Ferrochelatase Allele is a Determinant of Biochemical Phenotype in a Mouse Model 
of Erythropoietic Protoporphyria. Gene Regul Syst Bio. 2008 May 29;2:233-41.
PubMed PMID: 19787086; PubMed Central PMCID: PMC2733089.

64: Kong XF, Ye J, Gao DY, Gong QM, Zhang DH, Lu ZM, Lu YM, Zhang XX.
Identification of a ferrochelatase mutation in a Chinese family with
erythropoietic protoporphyria. J Hepatol. 2008 Feb;48(2):375-9. Epub 2007 Nov 26.
PubMed PMID: 18160121.

65: Taketani S, Ishigaki M, Mizutani A, Uebayashi M, Numata M, Ohgari Y, Kitajima
S. Heme synthase (ferrochelatase) catalyzes the removal of iron from heme and
demetalation of metalloporphyrins. Biochemistry. 2007 Dec 25;46(51):15054-61.
Epub 2007 Nov 29. PubMed PMID: 18044970.

66: Lelli SM, Mazzetti MB, San Martín de Viale LC. Hepatic alteration of
tryptophan metabolism in an acute porphyria model Its relation with gluconeogenic
blockage. Biochem Pharmacol. 2008 Feb 1;75(3):704-12. Epub 2007 Oct 2. PubMed
PMID: 17996218.

67: Jaschke PR, Beatty JT. The photosystem of Rhodobacter sphaeroides assembles
with zinc bacteriochlorophyll in a bchD (magnesium chelatase) mutant.
Biochemistry. 2007 Oct 30;46(43):12491-500. Epub 2007 Oct 2. PubMed PMID:
17910480.

68: Di Pierro E, Brancaleoni V, Besana V, Ausenda S, Drury S, Cappellini MD. A
10376 bp deletion of FECH gene responsible for erythropoietic protoporphyria.
Blood Cells Mol Dis. 2008 Mar-Apr;40(2):233-6. Epub 2007 Sep 20. PubMed PMID:
17888693.

69: Medlock AE, Dailey TA, Ross TA, Dailey HA, Lanzilotta WN. A pi-helix switch
selective for porphyrin deprotonation and product release in human
ferrochelatase. J Mol Biol. 2007 Nov 2;373(4):1006-16. Epub 2007 Aug 23. PubMed
PMID: 17884090; PubMed Central PMCID: PMC2083577.

70: Brancaleoni V, Di Pierro E, Besana V, Ausenda S, Drury S, Cappellini MD.
Novel human pathological mutations. Gene symbol: FECH. Disease: porphyria,
erythropoietic. Hum Genet. 2007 Jun;121(5):646. PubMed PMID: 17879435.

71: Herrero C, To-Figueras J, Badenas C, Méndez M, Serrano P, Enríquez-Salamanca 
R, Lecha M. Clinical, biochemical, and genetic study of 11 patients with
erythropoietic protoporphyria including one with homozygous disease. Arch
Dermatol. 2007 Sep;143(9):1125-9. PubMed PMID: 17875872.

72: Kemmner W, Wan K, Rüttinger S, Ebert B, Macdonald R, Klamm U, Moesta KT.
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation 
in colon cancer. FASEB J. 2008 Feb;22(2):500-9. Epub 2007 Sep 17. PubMed PMID:
17875605.

73: Holme SA, Worwood M, Anstey AV, Elder GH, Badminton MN. Erythropoiesis and
iron metabolism in dominant erythropoietic protoporphyria. Blood. 2007 Dec
1;110(12):4108-10. Epub 2007 Sep 5. PubMed PMID: 17804693.

74: Ruiz-Galindo E, Arenas-Huertero F, Ramón-Gallegos E. Expression of genes
involved in heme biosynthesis in the human retinoblastoma cell lines WERI-Rb-1
and Y79: implications for photodynamic therapy. J Exp Clin Cancer Res. 2007
Jun;26(2):195-200. PubMed PMID: 17725098.

75: Zhou SN, Xiao SX, Peng ZH, Li BX, Li XL, Liu Y, Luo SJ. A novel mutation of
the FECH gene in a Chinese family with erythropoietic protoporphyria. J Dermatol 
Sci. 2007 Nov;48(2):145-7. Epub 2007 Aug 27. PubMed PMID: 17723290.

76: Berroeta L, Man I, Goudie DR, Whatley SD, Elder GH, Ibbotson SH. Late
presentation of erythropoietic protoporphyria: case report and genetic analysis
of family members. Br J Dermatol. 2007 Nov;157(5):1030-1. Epub 2007 Aug 17.
PubMed PMID: 17711525.

77: Pinto R, Harrison JS, Hsu T, Jacobs WR Jr, Leyh TS. Sulfite reduction in
mycobacteria. J Bacteriol. 2007 Sep;189(18):6714-22. Epub 2007 Jul 20. PubMed
PMID: 17644602; PubMed Central PMCID: PMC2045171.

78: Masubuchi Y, Horie T. Toxicological significance of mechanism-based
inactivation of cytochrome p450 enzymes by drugs. Crit Rev Toxicol. 2007
Jun;37(5):389-412. Review. PubMed PMID: 17612953.

79: Gooijert KE, Havinga R, Oosterloo-Duinkerken AR, Venekamp-Hoolsema EE,
Kuipers F, Verkade HJ. Stimulation of fecal fat excretion and the disposal of
protoporphyrin in a murine model for erythropoietic protoporphyria. Am J Physiol 
Gastrointest Liver Physiol. 2007 Aug;293(2):G510-6. Epub 2007 Jun 28. PubMed
PMID: 17600043.

80: Whatley SD, Mason NG, Holme SA, Anstey AV, Elder GH, Badminton MN. Gene
dosage analysis identifies large deletions of the FECH gene in 10% of families
with erythropoietic protoporphyria. J Invest Dermatol. 2007 Dec;127(12):2790-4.
Epub 2007 Jun 28. PubMed PMID: 17597821.

81: Pisarchik A, Petri R, Schmidt-Dannert C. Probing the structural plasticity of
an archaeal primordial cobaltochelatase CbiX(S). Protein Eng Des Sel. 2007
Jun;20(6):257-65. Epub 2007 Jun 21. PubMed PMID: 17584754.

82: Dolezal P, Dancis A, Lesuisse E, Sutak R, Hrdý I, Embley TM, Tachezy J.
Frataxin, a conserved mitochondrial protein, in the hydrogenosome of Trichomonas 
vaginalis. Eukaryot Cell. 2007 Aug;6(8):1431-8. Epub 2007 Jun 15. PubMed PMID:
17573543; PubMed Central PMCID: PMC1951141.

83: Hedtke B, Alawady A, Chen S, Börnke F, Grimm B. HEMA RNAi silencing reveals a
control mechanism of ALA biosynthesis on Mg chelatase and Fe chelatase. Plant Mol
Biol. 2007 Aug;64(6):733-42. Epub 2007 Jun 15. PubMed PMID: 17571216.

84: Dailey HA, Wu CK, Horanyi P, Medlock AE, Najahi-Missaoui W, Burden AE, Dailey
TA, Rose J. Altered orientation of active site residues in variants of human
ferrochelatase. Evidence for a hydrogen bond network involved in catalysis.
Biochemistry. 2007 Jul 10;46(27):7973-9. Epub 2007 Jun 14. PubMed PMID: 17567154;
PubMed Central PMCID: PMC2424199.

85: Hoggins M, Dailey HA, Hunter CN, Reid JD. Direct measurement of metal ion
chelation in the active site of human ferrochelatase. Biochemistry. 2007 Jul
10;46(27):8121-7. Epub 2007 Jun 13. PubMed PMID: 17566985; PubMed Central PMCID: 
PMC2396339.

86: Tzvetkova-Chevolleau T, Franck F, Alawady AE, Dall'Osto L, Carrière F, Bassi 
R, Grimm B, Nussaume L, Havaux M. The light stress-induced protein ELIP2 is a
regulator of chlorophyll synthesis in Arabidopsis thaliana. Plant J. 2007
Jun;50(5):795-809. PubMed PMID: 17553115.

87: Kelly SC, Purcell SM, Griffin TD. Erythropoietic Protoporphyria
(Erythrohepatic Protoporphyria). Pediatr Dermatol. 2007 Apr 8. [Epub ahead of
print] PubMed PMID: 17509112.

88: Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G. Hemin rescues
adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient
oligodendroglioma cells. Biochim Biophys Acta. 2007 Jul;1772(7):773-80. Epub 2007
Apr 10. PubMed PMID: 17499976.

89: Bencze KZ, Yoon T, Millán-Pacheco C, Bradley PB, Pastor N, Cowan JA, Stemmler
TL. Human frataxin: iron and ferrochelatase binding surface. Chem Commun (Camb). 
2007 May 14;(18):1798-800. Epub 2007 Mar 28. PubMed PMID: 17476391.

90: Ikegami A, Yoshimura N, Motohashi K, Takahashi S, Romano PG, Hisabori T,
Takamiya K, Masuda T. The CHLI1 subunit of Arabidopsis thaliana magnesium
chelatase is a target protein of the chloroplast thioredoxin. J Biol Chem. 2007
Jul 6;282(27):19282-91. Epub 2007 May 1. PubMed PMID: 17472958.

91: Nagai S, Koide M, Takahashi S, Kikuta A, Aono M, Sasaki-Sekimoto Y, Ohta H,
Takamiya K, Masuda T. Induction of isoforms of tetrapyrrole biosynthetic enzymes,
AtHEMA2 and AtFC1, under stress conditions and their physiological functions in
Arabidopsis. Plant Physiol. 2007 Jun;144(2):1039-51. Epub 2007 Apr 6. PubMed
PMID: 17416636; PubMed Central PMCID: PMC1914178.

92: Eefsen M, Rasmussen A, Wulf HC, Brock A, Hansen BA. Erythropoietic
protoporphyria and pretransplantation treatment with nonbiological liver assist
devices. Liver Transpl. 2007 May;13(5):655-7. PubMed PMID: 17377916.

93: Jonker JW, Musters S, Vlaming ML, Plösch T, Gooijert KE, Hillebrand MJ,
Rosing H, Beijnen JH, Verkade HJ, Schinkel AH. Breast cancer resistance protein
(Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of
conjugated protoporphyrin IX. Am J Physiol Cell Physiol. 2007
Jun;292(6):C2204-12. Epub 2007 Feb 21. PubMed PMID: 17314268.

94: Abitbol M, Puy H, Sabaté JM, Guénet JL, Deybach JC, Montagutelli X.
Ursodesoxycholic acid and heme-arginate are unable to improve hematopoiesis and
liver injury in an erythropoietic protoporphyria mouse model. Physiol Res.
2006;55 Suppl 2:S93-101. PubMed PMID: 17298226.

95: Di Pierro E, Brancaleoni V, Moriondo V, Besana V, Cappellini MD. Gene symbol:
FECH. Disease: Porphyria, erythropoietic. Accession #Hg0501. Hum Genet. 2006
Feb;118(6):776. PubMed PMID: 17297688.

96: Medlock A, Swartz L, Dailey TA, Dailey HA, Lanzilotta WN. Substrate
interactions with human ferrochelatase. Proc Natl Acad Sci U S A. 2007 Feb
6;104(6):1789-93. Epub 2007 Jan 29. PubMed PMID: 17261801; PubMed Central PMCID: 
PMC1794275.

97: Rougée L, Downs CA, Richmond RH, Ostrander GK. Alteration of normal cellular 
profiles in the Scleractinian coral (Pocillopora damicornis) following laboratory
exposure to fuel oil. Environ Toxicol Chem. 2006 Dec;25(12):3181-7. PubMed PMID: 
17220087.

98: Di Pierro E, Brancaleoni V, Moriondo V, Besana V, Cappellini MD. Co-existence
of two functional mutations on the same allele of the human ferrochelatase gene
in erythropoietic protoporphyria. Clin Genet. 2007 Jan;71(1):84-8. PubMed PMID:
17204051.

99: Hansson MD, Karlberg T, Rahardja MA, Al-Karadaghi S, Hansson M. Amino acid
residues His183 and Glu264 in Bacillus subtilis ferrochelatase direct and
facilitate the insertion of metal ion into protoporphyrin IX. Biochemistry. 2007 
Jan 9;46(1):87-94. PubMed PMID: 17198378.

100: Aurizi C, Schneider-Yin X, Sorge F, Macrì A, Minder EI, Biolcati G.
Heterogeneity of mutations in the ferrochelatase gene in Italian patients with
erythropoietic protoporphyria. Mol Genet Metab. 2007 Apr;90(4):402-7. Epub 2006
Dec 29. PubMed PMID: 17196862.

101: Yamamoto F, Ohgari Y, Yamaki N, Kitajima S, Shimokawa O, Matsui H, Taketani 
S. The role of nitric oxide in delta-aminolevulinic acid (ALA)-induced
photosensitivity of cancerous cells. Biochem Biophys Res Commun. 2007 Feb
16;353(3):541-6. Epub 2006 Dec 22. PubMed PMID: 17196160.

102: Downs C, Downs A. Preliminary examination of short-term cellular
toxicological responses of the coral Madracis mirabilis to acute Irgarol 1051
exposure. Arch Environ Contam Toxicol. 2007 Jan;52(1):47-57. Epub 2006 Nov 28.
PubMed PMID: 17136316.

103: Rand EB, Bunin N, Cochran W, Ruchelli E, Olthoff KM, Bloomer JR. Sequential 
liver and bone marrow transplantation for treatment of erythropoietic
protoporphyria. Pediatrics. 2006 Dec;118(6):e1896-9. Epub 2006 Oct 30. PubMed
PMID: 17074841.

104: Pandolfo M. Iron and Friedreich ataxia. J Neural Transm Suppl.
2006;(70):143-6. Review. PubMed PMID: 17017521.

105: Lyoumi S, Abitbol M, Andrieu V, Henin D, Robert E, Schmitt C, Gouya L, de
Verneuil H, Deybach JC, Montagutelli X, Beaumont C, Puy H. Increased plasma
transferrin, altered body iron distribution, and microcytic hypochromic anemia in
ferrochelatase-deficient mice. Blood. 2007 Jan 15;109(2):811-8. Epub 2006 Sep 26.
PubMed PMID: 17003376.

106: Saruwatari H, Ueki Y, Yotsumoto S, Shimada T, Fukumaru S, Kanekura T,
Kanzaki T. Genetic analysis of the ferrochelatase gene in eight Japanese patients
from seven families with erythropoietic protoporphyria. J Dermatol. 2006
Sep;33(9):603-8. PubMed PMID: 16958804.

107: Bharati A, Badminton MN, Whatley SD, O'Brien DV, Bell HK. Late-onset
erythropoietic protoporphyria in association with haematological malignancy. Clin
Exp Dermatol. 2006 Sep;31(5):668-70. PubMed PMID: 16901306.

108: Sarkany RP, Ross G, Willis F. Acquired erythropoietic protoporphyria as a
result of myelodysplasia causing loss of chromosome 18. Br J Dermatol. 2006
Aug;155(2):464-6. PubMed PMID: 16882191.

109: Steensma DP, Hecksel KA, Porcher JC, Lasho TL. Candidate gene mutation
analysis in idiopathic acquired sideroblastic anemia (refractory anemia with
ringed sideroblasts). Leuk Res. 2007 May;31(5):623-8. Epub 2006 Jul 25. PubMed
PMID: 16870250.

110: Cobbold C, Roberts A, Badminton M. Erythropoietic protoporphyria: a
functional analysis of the leader sequence of human ferrochelatase. Mol Genet
Metab. 2006 Nov;89(3):227-32. Epub 2006 Jul 17. PubMed PMID: 16844398.

111: Ajioka RS, Phillips JD, Kushner JP. Biosynthesis of heme in mammals. Biochim
Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3. Review. PubMed PMID:
16839620.

112: Jarzecki AA, Spiro TG. Porphyrin distortion from resonance Raman intensities
of out-of-plane modes: Computation and modeling of N-methylmesoporphyrin, a
ferrochelatase transition state analog. J Phys Chem A. 2005 Jan 27;109(3):421-30.
PubMed PMID: 16833362.

113: Bloomer JR, Wang Y, Singhal A, Risheg H. Biochemical abnormality in
erythropoietic protoporphyria: cause and consequences. J Pediatr Gastroenterol
Nutr. 2006 Jul;43 Suppl 1:S36-40. PubMed PMID: 16819399.

114: Wong KF, Ho JW. Identification of histidine-60 interaction with copper in
activation of Chironomidae ferrochelatase. Protein Pept Lett. 2006;13(5):443-6.
PubMed PMID: 16800796.

115: Nakano H, Nakano A, Toyomaki Y, Ohashi S, Harada K, Moritsugu R, Takeda H,
Kawada A, Mitsuhashi Y, Hanada K. Novel ferrochelatase mutations in Japanese
patients with erythropoietic protoporphyria: high frequency of the splice site
modulator IVS3-48C polymorphism in the Japanese population. J Invest Dermatol.
2006 Dec;126(12):2717-9. Epub 2006 Jun 22. PubMed PMID: 16794582.

116: Shi Z, Ferreira GC. Modulation of inhibition of ferrochelatase by
N-methylprotoporphyrin. Biochem J. 2006 Oct 1;399(1):21-8. PubMed PMID: 16792525;
PubMed Central PMCID: PMC1570166.

117: Cook JD, Bencze KZ, Jankovic AD, Crater AK, Busch CN, Bradley PB, Stemmler
AJ, Spaller MR, Stemmler TL. Monomeric yeast frataxin is an iron-binding protein.
Biochemistry. 2006 Jun 27;45(25):7767-77. PubMed PMID: 16784228; PubMed Central
PMCID: PMC2518068.

118: Wood LH, Whatley SD, McKenna K, Badminton MN. Exonic deletions as a cause of
erythropoietic protoporphyria. Ann Clin Biochem. 2006 May;43(Pt 3):229-32. PubMed
PMID: 16704762.

119: Feissner RE, Richard-Fogal CL, Frawley ER, Loughman JA, Earley KW, Kranz RG.
Recombinant cytochromes c biogenesis systems I and II and analysis of haem
delivery pathways in Escherichia coli. Mol Microbiol. 2006 May;60(3):563-77.
PubMed PMID: 16629661.

120: O'Rourke BA, Dennis JA, Healy PJ. Internal restriction sites: quality
assurance aids in genotyping. J Vet Diagn Invest. 2006 Mar;18(2):195-7. PubMed
PMID: 16617701.

121: Vilchis F, Ramos L, Timossi C, Chávez B. The influence of sex steroid
hormones on ferrochelatase gene expression in Harderian gland of hamster
(Mesocricetus auratus). J Endocrinol. 2006 Apr;189(1):103-12. PubMed PMID:
16614385.

122: Shepherd M, Dailey TA, Dailey HA. A new class of [2Fe-2S]-cluster-containing
protoporphyrin (IX) ferrochelatases. Biochem J. 2006 Jul 1;397(1):47-52. PubMed
PMID: 16548850; PubMed Central PMCID: PMC1479749.

123: Mohanty S, Grimm B, Tripathy BC. Light and dark modulation of chlorophyll
biosynthetic genes in response to temperature. Planta. 2006 Aug;224(3):692-9.
Epub 2006 Mar 8. PubMed PMID: 16523349.

124: Shi Z, Franco R, Haddad R, Shelnutt JA, Ferreira GC. The conserved
active-site loop residues of ferrochelatase induce porphyrin conformational
changes necessary for catalysis. Biochemistry. 2006 Mar 7;45(9):2904-12. PubMed
PMID: 16503645.

125: Al-Karadaghi S, Franco R, Hansson M, Shelnutt JA, Isaya G, Ferreira GC.
Chelatases: distort to select? Trends Biochem Sci. 2006 Mar;31(3):135-42. Epub
2006 Feb 15. PubMed PMID: 16469498.

126: Hansson MD, Lindstam M, Hansson M. Crosstalk between metal ions in Bacillus 
subtilis ferrochelatase. J Biol Inorg Chem. 2006 Apr;11(3):325-33. Epub 2006 Feb 
2. PubMed PMID: 16453119.

127: Kroeze EJ, Zentek J, Edixhoven-Bosdijk A, Rothuizen J, van den Ingh TS.
Transient erythropoietic protoporphyria associated with chronic hepatitis and
cirrhosis in a cohort of German shepherd dogs. Vet Rec. 2006 Jan 28;158(4):120-4.
PubMed PMID: 16443837.

128: Auclair S, Feillet-Coudray C, Coudray C, Schneider S, Muckenthaler MU, Mazur
A. Mild copper deficiency alters gene expression of proteins involved in iron
metabolism. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):15-20. Epub 2006 Jan 5.
PubMed PMID: 16406711.

129: Inoiatova FKh, Akbarova DSh. [Change in hemoproteid metabolism and its
importance in the development of disorders of detoxication processes in patients 
with iron-deficiency anemia]. Lik Sprava. 2005 Jul-Sep;(5-6):64-7. Russian.
PubMed PMID: 16396297.

130: Gouya L, Martin-Schmitt C, Robreau AM, Austerlitz F, Da Silva V, Brun P,
Simonin S, Lyoumi S, Grandchamp B, Beaumont C, Puy H, Deybach JC. Contribution of
a common single-nucleotide polymorphism to the genetic predisposition for
erythropoietic protoporphyria. Am J Hum Genet. 2006 Jan;78(1):2-14. Epub 2005 Nov
15. PubMed PMID: 16385445; PubMed Central PMCID: PMC1380220.

131: Atteia A, van Lis R, Beale SI. Enzymes of the heme biosynthetic pathway in
the nonphotosynthetic alga Polytomella sp. Eukaryot Cell. 2005 Dec;4(12):2087-97.
PubMed PMID: 16339726; PubMed Central PMCID: PMC1317499.

132: van Lis R, Atteia A, Nogaj LA, Beale SI. Subcellular localization and
light-regulated expression of protoporphyrinogen IX oxidase and ferrochelatase in
Chlamydomonas reinhardtii. Plant Physiol. 2005 Dec;139(4):1946-58. Epub 2005 Nov 
23. PubMed PMID: 16306143; PubMed Central PMCID: PMC1310572.

133: Ohgari Y, Nakayasu Y, Kitajima S, Sawamoto M, Mori H, Shimokawa O, Matsui H,
Taketani S. Mechanisms involved in delta-aminolevulinic acid (ALA)-induced
photosensitivity of tumor cells: relation of ferrochelatase and uptake of ALA to 
the accumulation of protoporphyrin. Biochem Pharmacol. 2005 Dec 19;71(1-2):42-9. 
Epub 2005 Nov 10. PubMed PMID: 16288996.

134: Meurs I, Hoekstra M, van Wanrooij EJ, Hildebrand RB, Kuiper J, Kuipers F,
Hardeman MR, Van Berkel TJ, Van Eck M. HDL cholesterol levels are an important
factor for determining the lifespan of erythrocytes. Exp Hematol. 2005
Nov;33(11):1309-19. PubMed PMID: 16263415.

135: Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR,
Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi GA. Frataxin deficiency
alters heme pathway transcripts and decreases mitochondrial heme metabolites in
mammalian cells. Hum Mol Genet. 2005 Dec 15;14(24):3787-99. Epub 2005 Oct 20.
PubMed PMID: 16239244.

136: Goodwin RG, Kell WJ, Laidler P, Long CC, Whatley SD, McKinley M, Badminton
MN, Burnett AK, Williams GT, Elder GH. Photosensitivity and acute liver injury in
myeloproliferative disorder secondary to late-onset protoporphyria caused by
deletion of a ferrochelatase gene in hematopoietic cells. Blood. 2006 Jan
1;107(1):60-2. Epub 2005 Sep 8. PubMed PMID: 16150949.

137: Shipovskov S, Karlberg T, Fodje M, Hansson MD, Ferreira GC, Hansson M,
Reimann CT, Al-Karadaghi S. Metallation of the transition-state inhibitor
N-methyl mesoporphyrin by ferrochelatase: implications for the catalytic reaction
mechanism. J Mol Biol. 2005 Oct 7;352(5):1081-90. PubMed PMID: 16140324.

138: Lelli SM, San Martín de Viale LC, Mazzetti MB. Response of glucose
metabolism enzymes in an acute porphyria model. Role of reactive oxygen species. 
Toxicology. 2005 Dec;216(1):49-58. Epub 2005 Aug 24. PubMed PMID: 16125296.

139: Elder G. Normal dermal ferrochelatase activity does not protect human skin
from protoporphyrin-induced photosensitivity. J Invest Dermatol. 2005
Sep;125(3):580; author reply 580-1. PubMed PMID: 16117803.

140: Oborník M, Green BR. Mosaic origin of the heme biosynthesis pathway in
photosynthetic eukaryotes. Mol Biol Evol. 2005 Dec;22(12):2343-53. Epub 2005 Aug 
10. PubMed PMID: 16093570.

141: Gao T, O'Brian MR. Iron-dependent cytochrome c1 expression is mediated by
the status of heme in Bradyrhizobium japonicum. J Bacteriol. 2005
Aug;187(15):5084-9. PubMed PMID: 16030200; PubMed Central PMCID: PMC1196039.

142: Sobotka R, Komenda J, Bumba L, Tichy M. Photosystem II assembly in CP47
mutant of Synechocystis sp. PCC 6803 is dependent on the level of chlorophyll
precursors regulated by ferrochelatase. J Biol Chem. 2005 Sep
9;280(36):31595-602. Epub 2005 Jul 18. PubMed PMID: 16027152.

143: Feissner RE, Beckett CS, Loughman JA, Kranz RG. Mutations in cytochrome
assembly and periplasmic redox pathways in Bordetella pertussis. J Bacteriol.
2005 Jun;187(12):3941-9. PubMed PMID: 15937156; PubMed Central PMCID: PMC1151747.

144: Badminton MN, Elder GH. Molecular mechanisms of dominant expression in
porphyria. J Inherit Metab Dis. 2005;28(3):277-86. Review. PubMed PMID: 15868463.

145: Di Pierro E, Cappellini MD, Mazzucchelli R, Moriondo V, Mologni D, Zanone
Poma B, Riva A. A point mutation affecting an SP1 binding site in the promoter of
the ferrochelatase gene impairs gene transcription and causes erythropoietic
protoporphyria. Exp Hematol. 2005 May;33(5):584-91. PubMed PMID: 15850836.

146: Parish T, Schaeffer M, Roberts G, Duncan K. HemZ is essential for heme
biosynthesis in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2005
May;85(3):197-204. PubMed PMID: 15850757.

147: Najahi-Missaoui W, Dailey HA. Production and characterization of
erythropoietic protoporphyric heterodimeric ferrochelatases. Blood. 2005 Aug
1;106(3):1098-104. Epub 2005 Apr 14. PubMed PMID: 15831704; PubMed Central PMCID:
PMC1473221.

148: Soldatova O, Apchelimov A, Radukina N, Ezhova T, Shestakov S, Ziemann V,
Hedtke B, Grimm B. An Arabidopsis mutant that is resistant to the
protoporphyrinogen oxidase inhibitor acifluorfen shows regulatory changes in
tetrapyrrole biosynthesis. Mol Genet Genomics. 2005 Jun;273(4):311-8. Epub 2005
Apr 7. PubMed PMID: 15815918.

149: Degenhardt J, Al-Masri AN, Kürkcüoglu S, Szankowski I, Gau AE.
Characterization by suppression subtractive hybridization of transcripts that are
differentially expressed in leaves of apple scab-resistant and susceptible
cultivars of Malus domestica. Mol Genet Genomics. 2005 Jun;273(4):326-35. Epub
2005 Apr 6. PubMed PMID: 15812649.

150: Davies R, Schuurman A, Barker CR, Clothier B, Chernova T, Higginson FM,
Judah DJ, Dinsdale D, Edwards RE, Greaves P, Gant TW, Smith AG. Hepatic gene
expression in protoporphyic Fech mice is associated with cholestatic injury but
not a marked depletion of the heme regulatory pool. Am J Pathol. 2005
Apr;166(4):1041-53. PubMed PMID: 15793285; PubMed Central PMCID: PMC1602388.

151: Inoiatova FKh, Oripov NN. [Activity of heme synthesis enzymes in the bone
marrow cells of rats with alimentary iron-deficient anemia]. Lik Sprava. 2004
Dec;(8):67-70. Russian. PubMed PMID: 15771077.

152: Bloomer J, Wang Y, Singhal A, Risheg H. Molecular studies of liver disease
in erythropoietic protoporphyria. J Clin Gastroenterol. 2005 Apr;39(4 Suppl
2):S167-75. Review. PubMed PMID: 15758654.

153: Gao Q, Das B, Sherman F, Maquat LE. Cap-binding protein 1-mediated and
eukaryotic translation initiation factor 4E-mediated pioneer rounds of
translation in yeast. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4258-63. Epub
2005 Mar 7. PubMed PMID: 15753296; PubMed Central PMCID: PMC555522.

154: Abitbol M, Bernex F, Puy H, Jouault H, Deybach JC, Guénet JL, Montagutelli
X. A mouse model provides evidence that genetic background modulates anemia and
liver injury in erythropoietic protoporphyria. Am J Physiol Gastrointest Liver
Physiol. 2005 Jun;288(6):G1208-16. Epub 2005 Jan 27. PubMed PMID: 15677551.

155: Navarro S, Del Hoyo P, Campos Y, Abitbol M, Morán-Jiménez MJ, García-Bravo
M, Ochoa P, Grau M, Montagutelli X, Frank J, Garesse R, Arenas J, de Salamanca
RE, Fontanellas A. Increased mitochondrial respiratory chain enzyme activities
correlate with minor extent of liver damage in mice suffering from erythropoietic
protoporphyria. Exp Dermatol. 2005 Jan;14(1):26-33. PubMed PMID: 15660916.

156: Eichbaum QG, Dzik WH, Chung RT, Szczepiorkowski ZM. Red blood cell exchange 
transfusion in two patients with advanced erythropoietic protoporphyria.
Transfusion. 2005 Feb;45(2):208-13. PubMed PMID: 15660829.

157: Pawliuk R, Tighe R, Wise RJ, Mathews-Roth MM, Leboulch P. Prevention of
murine erythropoietic protoporphyria-associated skin photosensitivity and liver
disease by dermal and hepatic ferrochelatase. J Invest Dermatol. 2005
Jan;124(1):256-62. PubMed PMID: 15654982.

158: O'Neill HA, Gakh O, Park S, Cui J, Mooney SM, Sampson M, Ferreira GC, Isaya 
G. Assembly of human frataxin is a mechanism for detoxifying redox-active iron.
Biochemistry. 2005 Jan 18;44(2):537-45. PubMed PMID: 15641778.

159: Alawady AE, Grimm B. Tobacco Mg protoporphyrin IX methyltransferase is
involved in inverse activation of Mg porphyrin and protoheme synthesis. Plant J. 
2005 Jan;41(2):282-90. PubMed PMID: 15634204.

160: Yang J, Ishimori K, O'Brian MR. Two heme binding sites are involved in the
regulated degradation of the bacterial iron response regulator (Irr) protein. J
Biol Chem. 2005 Mar 4;280(9):7671-6. Epub 2004 Dec 21. PubMed PMID: 15613477.

161: He Y, Alam SL, Proteasa SV, Zhang Y, Lesuisse E, Dancis A, Stemmler TL.
Yeast frataxin solution structure, iron binding, and ferrochelatase interaction. 
Biochemistry. 2004 Dec 28;43(51):16254-62. PubMed PMID: 15610019.

162: Venkateshrao S, Yin J, Jarzecki AA, Schultz PG, Spiro TG. Porphyrin
distortion during affinity maturation of a ferrochelatase antibody, monitored by 
Resonance Raman spectroscopy. J Am Chem Soc. 2004 Dec 22;126(50):16361-7. PubMed 
PMID: 15600337.

163: O'Neill HA, Gakh O, Isaya G. Supramolecular assemblies of human frataxin are
formed via subunit-subunit interactions mediated by a non-conserved
amino-terminal region. J Mol Biol. 2005 Jan 21;345(3):433-9. PubMed PMID:
15581888.

164: Ohgari Y, Sawamoto M, Yamamoto M, Kohno H, Taketani S. Ferrochelatase
consisting of wild-type and mutated subunits from patients with a
dominant-inherited disease, erythropoietic protoporphyria, is an active but
unstable dimer. Hum Mol Genet. 2005 Jan 15;14(2):327-34. Epub 2004 Dec 1. PubMed 
PMID: 15574461.

165: Raux-Deery E, Leech HK, Nakrieko KA, McLean KJ, Munro AW, Heathcote P, Rigby
SE, Smith AG, Warren MJ. Identification and characterization of the terminal
enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located
sirohydrochlorin ferrochelatase containing a 2FE-2S center. J Biol Chem. 2005 Feb
11;280(6):4713-21. Epub 2004 Nov 15. PubMed PMID: 15545265.

166: Leung YK, Wong KF, Lee HK, Ho JW. Cloning and characterization of
chironomidae ferrochelatase: copper activation of the purified ferrochelatase.
Mol Cell Biochem. 2004 Jul;262(1-2):225-31. PubMed PMID: 15532727.

167: Ahuja U, Thöny-Meyer L. CcmD is involved in complex formation between CcmC
and the heme chaperone CcmE during cytochrome c maturation. J Biol Chem. 2005 Jan
7;280(1):236-43. Epub 2004 Oct 28. PubMed PMID: 15513913.

168: Franco R, Bai G, Prosinecki V, Abrunhosa F, Ferreira GC, Bastos M.
Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal
stability of the enzyme. Biochem J. 2005 Mar 15;386(Pt 3):599-605. PubMed PMID:
15496139; PubMed Central PMCID: PMC1134880.

169: Brown BM, Wang Z, Brown KR, Cricco JA, Hegg EL. Heme O synthase and heme A
synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in
Escherichia coli. Biochemistry. 2004 Oct 26;43(42):13541-8. PubMed PMID:
15491161.

170: Dailey TA, Woodruff JH, Dailey HA. Examination of mitochondrial protein
targeting of haem synthetic enzymes: in vivo identification of three functional
haem-responsive motifs in 5-aminolaevulinate synthase. Biochem J. 2005 Mar
1;386(Pt 2):381-6. Erratum in: Biochem J. 2005 Nov 1;391(Pt 3):711. PubMed PMID: 
15482256; PubMed Central PMCID: PMC1134803.

171: Santos R, Buisson N, Knight SA, Dancis A, Camadro JM, Lesuisse E. Candida
albicans lacking the frataxin homologue: a relevant yeast model for studying the 
role of frataxin. Mol Microbiol. 2004 Oct;54(2):507-19. PubMed PMID: 15469520.

172: Onaga Y, Ido A, Uto H, Hasuike S, Kusumoto K, Moriuchi A, Numata M, Nagata
K, Hori T, Hayashi K, Tsubouchi H. Hypermethylation of the wild-type
ferrochelatase allele is closely associated with severe liver complication in a
family with erythropoietic protoporphyria. Biochem Biophys Res Commun. 2004 Sep
3;321(4):851-8. PubMed PMID: 15358105.

173: Zhang AS, Sheftel AD, Ponka P. Intracellular kinetics of iron in
reticulocytes: evidence for endosome involvement in iron targeting to
mitochondria. Blood. 2005 Jan 1;105(1):368-75. Epub 2004 Aug 26. PubMed PMID:
15331447.

174: Liu YL, Ang SO, Weigent DA, Prchal JT, Bloomer JR. Regulation of
ferrochelatase gene expression by hypoxia. Life Sci. 2004 Sep 10;75(17):2035-43. 
PubMed PMID: 15312748.

175: Varadharajan S, Sagar BK, Rangarajan PN, Padmanaban G. Localization of
ferrochelatase in Plasmodium falciparum. Biochem J. 2004 Dec 1;384(Pt 2):429-36. 
PubMed PMID: 15307818; PubMed Central PMCID: PMC1134127.

176: Kwon SJ, Petri R, DeBoer AL, Schmidt-Dannert C. A high-throughput screen for
porphyrin metal chelatases: application to the directed evolution of
ferrochelatases for metalloporphyrin biosynthesis. Chembiochem. 2004 Aug
6;5(8):1069-74. PubMed PMID: 15300829.

177: Whatley SD, Mason NG, Khan M, Zamiri M, Badminton MN, Missaoui WN, Dailey
TA, Dailey HA, Douglas WS, Wainwright NJ, Elder GH. Autosomal recessive
erythropoietic protoporphyria in the United Kingdom: prevalence and relationship 
to liver disease. J Med Genet. 2004 Aug;41(8):e105. PubMed PMID: 15286165; PubMed
Central PMCID: PMC1473220.

178: Richard E, Robert E, Cario-André M, Ged C, Géronimi F, Gerson SL, de
Verneuil H, Moreau-Gaudry F. Hematopoietic stem cell gene therapy of murine
protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug
selection. Gene Ther. 2004 Nov;11(22):1638-47. PubMed PMID: 15284838.

179: Atamna H, Frey WH 2nd. A role for heme in Alzheimer's disease: heme binds
amyloid beta and has altered metabolism. Proc Natl Acad Sci U S A. 2004 Jul
27;101(30):11153-8. Epub 2004 Jul 19. PubMed PMID: 15263070; PubMed Central
PMCID: PMC503755.

180: Haffor SA, Al-Ayed MI. The effect of lead bioaccumulation on haem
biosynthetic enzymes in fish. J Environ Biol. 2003 Jul;24(3):271-80. PubMed PMID:
15259603.

181: Brown KR, Brown BM, Hoagland E, Mayne CL, Hegg EL. Heme A synthase does not 
incorporate molecular oxygen into the formyl group of heme A. Biochemistry. 2004 
Jul 13;43(27):8616-24. PubMed PMID: 15236569.

182: Atamna H. Heme, iron, and the mitochondrial decay of ageing. Ageing Res Rev.
2004 Jul;3(3):303-18. Review. PubMed PMID: 15231238.

183: Isaya G, O'Neill HA, Gakh O, Park S, Mantcheva R, Mooney SM. Functional
studies of frataxin. Acta Paediatr Suppl. 2004 May;93(445):68-71; discussion
72-3. PubMed PMID: 15176725.

184: Ickowicz Schwartz D, Gozlan Y, Greenbaum L, Babushkina T, Katcoff DJ, Malik 
Z. Differentiation-dependent photodynamic therapy regulated by porphobilinogen
deaminase in B16 melanoma. Br J Cancer. 2004 May 4;90(9):1833-41. PubMed PMID:
15150593; PubMed Central PMCID: PMC2409749.

185: Lange H, Mühlenhoff U, Denzel M, Kispal G, Lill R. The heme synthesis defect
of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by 
reversible inhibition of ferrochelatase. J Biol Chem. 2004 Jul 9;279(28):29101-8.
Epub 2004 May 5. PubMed PMID: 15128732.

186: Yoon T, Cowan JA. Frataxin-mediated iron delivery to ferrochelatase in the
final step of heme biosynthesis. J Biol Chem. 2004 Jun 18;279(25):25943-6. Epub
2004 Apr 27. PubMed PMID: 15123683.

187: Muzyka V, Scheepers PT, Bogovski S, Lang I, Schmidt N, Ryazanov V, Veidebaum
T. Porphyrin metabolism in lymphocytes of miners exposed to diesel exhaust at oil
shale mine. Sci Total Environ. 2004 Apr 25;322(1-3):41-50. PubMed PMID: 15081736.

188: Koch M, Breithaupt C, Kiefersauer R, Freigang J, Huber R, Messerschmidt A.
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and
chlorophyll biosynthesis. EMBO J. 2004 Apr 21;23(8):1720-8. Epub 2004 Apr 1.
PubMed PMID: 15057273; PubMed Central PMCID: PMC394243.

189: Di Pierro E, Moriondo V, Cappellini MD. Human gene mutations. Gene symbol:
FECH. Disease: Porphyria, erythropoietic. Hum Genet. 2004 Jan;114(2):221. PubMed 
PMID: 15046047.

190: Fontanellas A, Navarro-Ordoñez S, Morán-Jiménez MJ, Guolo M, Franco C,
García-Bravo M, Pataro L, Batlle A, de Salamanca RE. Hemoglobin content is
increased in the human erythroleukemia K562 cell line by a 56.2-kD peptide from
uremic plasma. Am J Nephrol. 2004 Mar-Apr;24(2):230-4. Epub 2004 Mar 15. PubMed
PMID: 15024177.

191: Shi Z, Ferreira GC. Probing the active site loop motif of murine
ferrochelatase by random mutagenesis. J Biol Chem. 2004 May 7;279(19):19977-86.
Epub 2004 Feb 23. PubMed PMID: 14981080.

192: Gouya L, Puy H, Robreau AM, Lyoumi S, Lamoril J, Da Silva V, Grandchamp B,
Deybach JC. Modulation of penetrance by the wild-type allele in dominantly
inherited erythropoietic protoporphyria and acute hepatic porphyrias. Hum Genet. 
2004 Feb;114(3):256-62. Epub 2003 Dec 11. PubMed PMID: 14669009.

193: Baysse C, Matthijs S, Schobert M, Layer G, Jahn D, Cornelis P. Co-ordination
of iron acquisition, iron porphyrin chelation and iron-protoporphyrin export via 
the cytochrome c biogenesis protein CcmC in Pseudomonas fluorescens.
Microbiology. 2003 Dec;149(Pt 12):3543-52. PubMed PMID: 14663086.

194: Hasui Y, Ikeda M, Tanabe H. [Porphyria]. Ryoikibetsu Shokogun Shirizu.
2003;(40):355-9. Review. Japanese. PubMed PMID: 14626138.

195: Stroupe ME, Leech HK, Daniels DS, Warren MJ, Getzoff ED. CysG structure
reveals tetrapyrrole-binding features and novel regulation of siroheme
biosynthesis. Nat Struct Biol. 2003 Dec;10(12):1064-73. Epub 2003 Nov 2. PubMed
PMID: 14595395.

196: Scruggs AW, Woodbury NW. Optical processing of bacterial libraries for
directed evolution. Biotechnol Bioeng. 2003 Nov 20;84(4):445-51. PubMed PMID:
14574702.

197: Risheg H, Chen FP, Bloomer JR. Genotypic determinants of phenotype in North 
American patients with erythropoietic protoporphyria. Mol Genet Metab. 2003
Sep-Oct;80(1-2):196-206. PubMed PMID: 14567969.

198: Hon T, Dodd A, Dirmeier R, Gorman N, Sinclair PR, Zhang L, Poyton RO. A
mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the
heme biosynthetic pathway affect Hap1 activity. J Biol Chem. 2003 Dec
12;278(50):50771-80. Epub 2003 Sep 25. PubMed PMID: 14512429.

199: Richard E, Géronimi F, Lalanne M, Ged C, Redonnet-Vernhet I, Lamrissi-Garcia
I, Gerson SL, de Verneuil H, Moreau-Gaudry F. A bicistronic SIN-lentiviral vector
containing G156A MGMT allows selection and metabolic correction of hematopoietic 
protoporphyric cell lines. J Gene Med. 2003 Sep;5(9):737-47. PubMed PMID:
12950064.

200: Masuda T, Suzuki T, Shimada H, Ohta H, Takamiya K. Subcellular localization 
of two types of ferrochelatase in cucumber. Planta. 2003 Aug;217(4):602-9. Epub
2003 Mar 22. PubMed PMID: 12905021.

201: Kwon SJ, de Boer AL, Petri R, Schmidt-Dannert C. High-level production of
porphyrins in metabolically engineered Escherichia coli: systematic extension of 
a pathway assembled from overexpressed genes involved in heme biosynthesis. Appl 
Environ Microbiol. 2003 Aug;69(8):4875-83. PubMed PMID: 12902282; PubMed Central 
PMCID: PMC169110.

202: Lew W. A novel ferrochelatase gene mutation (IVS1-2 A-->C) in erythropoietic
protoporphyria. J Invest Dermatol. 2003 Aug;121(2):425-7. PubMed PMID: 12880438.

203: Guégan R, Camadro JM, Saint Girons I, Picardeau M. Leptospira spp. possess a
complete haem biosynthetic pathway and are able to use exogenous haem sources.
Mol Microbiol. 2003 Aug;49(3):745-54. PubMed PMID: 12864856.

204: Yin J, Beuscher AE 4th, Andryski SE, Stevens RC, Schultz PG. Structural
plasticity and the evolution of antibody affinity and specificity. J Mol Biol.
2003 Jul 18;330(4):651-6. PubMed PMID: 12850137.

205: Muzyka V, Bogovski S, Scheepers P, Volf J, Kusova J. Effects of occupational
exposure to diesel exhaust on porphyrin metabolism in lymphocytes of workers
employed at black coal and oil-shale mines. Am J Ind Med. 2003 Jul;44(1):70-4.
PubMed PMID: 12822138.

206: Shi Z, Ferreira GC. A continuous anaerobic fluorimetric assay for
ferrochelatase by monitoring porphyrin disappearance. Anal Biochem. 2003 Jul
1;318(1):18-24. PubMed PMID: 12782026.

207: Lecerof D, Fodje MN, Alvarez León R, Olsson U, Hansson A, Sigfridsson E,
Ryde U, Hansson M, Al-Karadaghi S. Metal binding to Bacillus subtilis
ferrochelatase and interaction between metal sites. J Biol Inorg Chem. 2003
Apr;8(4):452-8. Epub 2003 Jan 18. PubMed PMID: 12761666.

208: Schoenfeld N, Mamet R, Minder EI, Schneider-Yin X. A "null allele" mutation 
is responsible for erythropoietic protoporphyria in an Israeli patient who
underwent liver transplantation: relationships among biochemical, clinical, and
genetic parameters. Blood Cells Mol Dis. 2003 May-Jun;30(3):298-301. PubMed PMID:
12737948.

209: Park S, Gakh O, O'Neill HA, Mangravita A, Nichol H, Ferreira GC, Isaya G.
Yeast frataxin sequentially chaperones and stores iron by coupling protein
assembly with iron oxidation. J Biol Chem. 2003 Aug 15;278(33):31340-51. Epub
2003 May 5. PubMed PMID: 12732649.

210: Hinnen P, Siersema PD, Edixhoven A, Wilson JH, de Rooij FW. Two course
illuminating scheme improves aminolevulinic acid photodynamic therapy in cell
cultures. Cell Mol Biol (Noisy-le-grand). 2002 Dec;48(8):903-9. PubMed PMID:
12699249.

211: Martinez di Montemuros F, Di Pierro E, Patti E, Tavazzi D, Danielli MG,
Biolcati G, Rocchi E, Cappellini MD. Molecular characterization of porphyrias in 
Italy: a diagnostic flow-chart. Cell Mol Biol (Noisy-le-grand). 2002
Dec;48(8):867-76. PubMed PMID: 12699245.

212: Lesuisse E, Santos R, Matzanke BF, Knight SA, Camadro JM, Dancis A. Iron use
for haeme synthesis is under control of the yeast frataxin homologue (Yfh1). Hum 
Mol Genet. 2003 Apr 15;12(8):879-89. PubMed PMID: 12668611.

213: Bogovski S, Muzyka V, Sergeyev B, Karlova S. Biomarkers of carcinogenic
contaminants in Baltic flounder (Platichthys flesus): temporal changes in urban
and non-urban sites in Tallinn bay. Environ Sci Pollut Res Int. 2002;Spec No
1:15-8. PubMed PMID: 12638743.

214: Wiman A, Floderus Y, Harper P. Novel mutations and phenotypic effect of the 
splice site modulator IVS3-48C in nine Swedish families with erythropoietic
protoporphyria. J Hum Genet. 2003;48(2):70-6. PubMed PMID: 12601550.

215: Sigfridsson E, Ryde U. The importance of porphyrin distortions for the
ferrochelatase reaction. J Biol Inorg Chem. 2003 Feb;8(3):273-82. Epub 2002 Nov
5. PubMed PMID: 12589563.

216: Sato S, Wilson RJ. Proteobacteria-like ferrochelatase in the malaria
parasite. Curr Genet. 2003 Feb;42(5):292-300. Epub 2003 Jan 18. PubMed PMID:
12589469.

217: Nilsson K, Lecerof D, Sigfridsson E, Ryde U. An automatic method to generate
force-field parameters for hetero-compounds. Acta Crystallogr D Biol Crystallogr.
2003 Feb;59(Pt 2):274-89. Epub 2003 Jan 23. PubMed PMID: 12554938.

218: Yin J, Andryski SE, Beuscher AE 4th, Stevens RC, Schultz PG. Structural
evidence for substrate strain in antibody catalysis. Proc Natl Acad Sci U S A.
2003 Feb 4;100(3):856-61. Epub 2003 Jan 24. PubMed PMID: 12552112; PubMed Central
PMCID: PMC298691.

219: Libbrecht L, Meerman L, Kuipers F, Roskams T, Desmet V, Jansen P. Liver
pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic
protoporphyria. J Pathol. 2003 Feb;199(2):191-200. PubMed PMID: 12533832.

220: Manivasager V, Heng PW, Hao J, Zheng W, Soo KC, Olivo M. A study of
5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems
of human bladder cancer. Int J Oncol. 2003 Feb;22(2):313-8. PubMed PMID:
12527928.

221: Sikora A, Grzesiuk E, Zbieć R, Janion C. Lethality of visible light for
Escherichia coli hemH1 mutants influence of defects in DNA repair. DNA Repair
(Amst). 2003 Jan 2;2(1):61-71. PubMed PMID: 12509268.

222: Fujita H, Nishitani C, Ogawa K. Lead, chemical porphyria, and heme as a
biological mediator. Tohoku J Exp Med. 2002 Feb;196(2):53-64. PubMed PMID:
12498316.

223: Taketani S, Kakimoto K, Ueta H, Masaki R, Furukawa T. Involvement of ABC7 in
the biosynthesis of heme in erythroid cells: interaction of ABC7 with
ferrochelatase. Blood. 2003 Apr 15;101(8):3274-80. Epub 2002 Dec 12. PubMed PMID:
12480705.

224: Krieg RC, Messmann H, Rauch J, Seeger S, Knuechel R. Metabolic
characterization of tumor cell-specific protoporphyrin IX accumulation after
exposure to 5-aminolevulinic acid in human colonic cells. Photochem Photobiol.
2002 Nov;76(5):518-25. PubMed PMID: 12462647.

225: Karlberg T, Lecerof D, Gora M, Silvegren G, Labbe-Bois R, Hansson M,
Al-Karadaghi S. Metal binding to Saccharomyces cerevisiae ferrochelatase.
Biochemistry. 2002 Nov 19;41(46):13499-506. PubMed PMID: 12427010.

226: Ríos de Molina MC, Mazzetti MB, Galigniana M, Aldonatti C, Tomio JM, San
Martín de Viale LC. The decrease in uroporphyrinogen decarboxylase activity
induced by ethanol predisposes rats to the development of porphyria and
accelerates xenobiotic-triggered porphyria, regardless of hepatic damage. Braz J 
Med Biol Res. 2002 Nov;35(11):1273-83. PubMed PMID: 12426626.

227: Atamna H, Killilea DW, Killilea AN, Ames BN. Heme deficiency may be a factor
in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci U S A. 2002 
Nov 12;99(23):14807-12. Epub 2002 Nov 4. PubMed PMID: 12417755; PubMed Central
PMCID: PMC137500.

228: Raux E, Leech HK, Beck R, Schubert HL, Santander PJ, Roessner CA, Scott AI, 
Martens JH, Jahn D, Thermes C, Rambach A, Warren MJ. Identification and
functional analysis of enzymes required for precorrin-2 dehydrogenation and metal
ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus
megaterium. Biochem J. 2003 Mar 1;370(Pt 2):505-16. PubMed PMID: 12408752; PubMed
Central PMCID: PMC1223173.

229: Gamble JT, Nakatsu K, Marks GS. Porphyrinogenic xenobiotic-induced
N-alkylprotoporphyrin IX formation: a bioassay utilizing chick embryo hepatic
ferrochelatase. J Pharmacol Toxicol Methods. 2002 Jan-Feb;47(1):25-32. PubMed
PMID: 12387936.

230: Singh DP, Cornah JE, Hadingham S, Smith AG. Expression analysis of the two
ferrochelatase genes in Arabidopsis in different tissues and under stress
conditions reveals their different roles in haem biosynthesis. Plant Mol Biol.
2002 Nov;50(4-5):773-88. PubMed PMID: 12374307.

231: Bhasin G, Kausar H, Athar M. Protoporphyrin-IX accumulation and cutaneous
tumor regression in mice using a ferrochelatase inhibitor. Cancer Lett. 2002 Dec 
10;187(1-2):9-16. PubMed PMID: 12359345.

232: Brown KR, Allan BM, Do P, Hegg EL. Identification of novel hemes generated
by heme A synthase: evidence for two successive monooxygenase reactions.
Biochemistry. 2002 Sep 10;41(36):10906-13. PubMed PMID: 12206660.

233: Sarkany RP. Erythropoietic protoporphyria (EPP) at 40. Where are we now?
Photodermatol Photoimmunol Photomed. 2002 Jun;18(3):147-52. Review. PubMed PMID: 
12207680.

234: Morris SD, Mason NG, Elder GH, Hawk JL, Sarkany RP. Ferrochelatase gene
polymorphism analysis for accurate genetic counselling in erythropoietic
protoporphyria. Br J Dermatol. 2002 Sep;147(3):572-4. PubMed PMID: 12207604.

235: Ponka P, Sheftel AD, Zhang AS. Iron targeting to mitochondria in erythroid
cells. Biochem Soc Trans. 2002 Aug;30(4):735-8. PubMed PMID: 12196181.

236: Leech HK, Raux-Deery E, Heathcote P, Warren MJ. Production of cobalamin and 
sirohaem in Bacillus megaterium: an investigation into the role of the
branchpoint chelatases sirohydrochlorin ferrochelatase (SirB) and
sirohydrochlorin cobalt chelatase (CbiX). Biochem Soc Trans. 2002
Aug;30(4):610-3. PubMed PMID: 12196147.

237: Schubert HL, Raux E, Matthews MA, Phillips JD, Wilson KS, Hill CP, Warren
MJ. Structural diversity in metal ion chelation and the structure of
uroporphyrinogen III synthase. Biochem Soc Trans. 2002 Aug;30(4):595-600. Review.
PubMed PMID: 12196144.

238: Dailey HA. Terminal steps of haem biosynthesis. Biochem Soc Trans. 2002
Aug;30(4):590-5. Review. PubMed PMID: 12196143.

239: Sassa S. [Contribution of Japanese researchers to progress in the field of
hematology in the last 100 years: Porphyria/congenital heme synthetase
deficiency]. Nippon Naika Gakkai Zasshi. 2002 Jul 10;91(7):2029-31. Japanese.
PubMed PMID: 12187670.

240: Schultz PG, Lerner RA. Completing the circle. Nature. 2002 Aug
1;418(6897):485. PubMed PMID: 12152057.

241: Magness ST, Maeda N, Brenner DA. An exon 10 deletion in the mouse
ferrochelatase gene has a dominant-negative effect and causes mild
protoporphyria. Blood. 2002 Aug 15;100(4):1470-7. PubMed PMID: 12149233.

242: Zoller H, Decristoforo C, Weiss G. Erythroid 5-aminolevulinate synthase,
ferrochelatase and DMT1 expression in erythroid progenitors: differential
pathways for erythropoietin and iron-dependent regulation. Br J Haematol. 2002
Aug;118(2):619-26. PubMed PMID: 12139757.

243: Ryde U, Olsen L, Nilsson K. Quantum chemical geometry optimizations in
proteins using crystallographic raw data. J Comput Chem. 2002 Aug;23(11):1058-70.
PubMed PMID: 12116392.

244: Cochón AC, González N, San Martín de Viale LC. Effects of the
porphyrinogenic compounds hexachlorobenzene and
3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism. Toxicology.
2002 Jul 15;176(3):209-19. PubMed PMID: 12093617.

245: Olsson U, Billberg A, Sjövall S, Al-Karadaghi S, Hansson M. In vivo and in
vitro studies of Bacillus subtilis ferrochelatase mutants suggest substrate
channeling in the heme biosynthesis pathway. J Bacteriol. 2002
Jul;184(14):4018-24. PubMed PMID: 12081974; PubMed Central PMCID: PMC135158.

246: Lu Y, Sousa A, Franco R, Mangravita A, Ferreira GC, Moura I, Shelnutt JA.
Binding of protoporphyrin IX and metal derivatives to the active site of
wild-type mouse ferrochelatase at low porphyrin-to-protein ratios. Biochemistry. 
2002 Jul 2;41(26):8253-62. PubMed PMID: 12081474.

247: Poh-Fitzpatrick MB, Wang X, Anderson KE, Bloomer JR, Bolwell B, Lichtin AE. 
Erythropoietic protoporphyria: altered phenotype after bone marrow
transplantation for myelogenous leukemia in a patient heteroallelic for
ferrochelatase gene mutations. J Am Acad Dermatol. 2002 Jun;46(6):861-6. PubMed
PMID: 12063482.

248: Foury F, Roganti T. Deletion of the mitochondrial carrier genes MRS3 and
MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient
strain. J Biol Chem. 2002 Jul 5;277(27):24475-83. Epub 2002 May 2. PubMed PMID:
12006577.

249: Schubert HL, Raux E, Brindley AA, Leech HK, Wilson KS, Hill CP, Warren MJ.
The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and
ferrochelatase. EMBO J. 2002 May 1;21(9):2068-75. PubMed PMID: 11980703; PubMed
Central PMCID: PMC125995.

250: Yasui Y, Muranaka S, Tahara T, Shimizu R, Watanabe S, Horie Y, Nanba E,
Uezato H, Takamiyagi A, Taketani S, Akagi R. A new ferrochelatase mutation
combined with low expression alleles in a Japanese patient with erythropoietic
protoporphyria. Clin Sci (Lond). 2002 May;102(5):501-6. PubMed PMID: 11980567.

251: Dailey TA, Dailey HA. Identification of [2Fe-2S] clusters in microbial
ferrochelatases. J Bacteriol. 2002 May;184(9):2460-4. PubMed PMID: 11948160;
PubMed Central PMCID: PMC134991.

252: Ferreira GC, Franco R, Mangravita A, George GN. Unraveling the
substrate-metal binding site of ferrochelatase: an X-ray absorption spectroscopic
study. Biochemistry. 2002 Apr 16;41(15):4809-18. PubMed PMID: 11939775.

253: Minder EI, Gouya L, Schneider-Yin X, Deybach JC. A genotype-phenotype
correlation between null-allele mutations in the ferrochelatase gene and liver
complication in patients with erythropoietic protoporphyria. Cell Mol Biol
(Noisy-le-grand). 2002 Feb;48(1):91-6. PubMed PMID: 11929053.

254: Chen FP, Risheg H, Liu Y, Bloomer J. Ferrochelatase gene mutations in
erythropoietic protoporphyria: focus on liver disease. Cell Mol Biol
(Noisy-le-grand). 2002 Feb;48(1):83-9. PubMed PMID: 11929052.

255: Aplin C, Whatley SD, Thompson P, Hoy T, Fisher P, Singer C, Lovell CR, Elder
GH. Late-onset erythropoietic porphyria caused by a chromosome 18q deletion in
erythroid cells. J Invest Dermatol. 2001 Dec;117(6):1647-9. PubMed PMID:
11886534.

256: Schneider-Yin X, Rüfenacht UB, Hergersberg M, Schnyder C, Deybach JC, Minder
EI. Haplotype analysis in determination of the heredity of erythropoietic
protoporphyria among Swiss families. J Invest Dermatol. 2001 Dec;117(6):1521-5.
PubMed PMID: 11886517.

257: Muzyka V, Bogovski S, Viitak A, Veidebaum T. Alterations of heme metabolism 
in lymphocytes and metal content in blood plasma as markers of diesel fuels
effects on human organism. Sci Total Environ. 2002 Mar 8;286(1-3):73-81. PubMed
PMID: 11886100.

258: Do KD, Banner BF, Katz E, Szymanski IO, Bonkovsky HL. Benefits of chronic
plasmapheresis and intravenous heme-albumin in erythropoietic protoporphyria
after orthotopic liver transplantation. Transplantation. 2002 Feb
15;73(3):469-72. PubMed PMID: 11884947.

259: Cornah JE, Roper JM, Pal Singh D, Smith AG. Measurement of ferrochelatase
activity using a novel assay suggests that plastids are the major site of haem
biosynthesis in both photosynthetic and non-photosynthetic cells of pea (Pisum
sativum L.). Biochem J. 2002 Mar 1;362(Pt 2):423-32. PubMed PMID: 11853551;
PubMed Central PMCID: PMC1222403.

260: Umbreit JN, Conrad ME, Hainsworth LN, Simovich M. The ferrireductase
paraferritin contains divalent metal transporter as well as mobilferrin. Am J
Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G534-9. PubMed PMID:
11842004.

261: Grzybowska E, Góra M, Plochocka D, Rytka J. Saccharomyces cerevisiae
ferrochelatase forms a homodimer. Arch Biochem Biophys. 2002 Feb 15;398(2):170-8.
PubMed PMID: 11831847.

262: Iwase M, Toh-e A. Nis1 encoded by YNL078W: a new neck protein of
Saccharomyces cerevisiae. Genes Genet Syst. 2001 Oct;76(5):335-43. PubMed PMID:
11817649.

263: Kanjo N, Nakahigashi K, Oeda K, Inokuchi H. Isolation and characterization
of a cDNA from soybean and its homolog from Escherichia coli, which both
complement the light sensitivity of Escherichia coli hemH mutant strain VS101.
Genes Genet Syst. 2001 Oct;76(5):327-34. PubMed PMID: 11817648.

264: Nakahigashi K, Kubo N, Narita S, Shimaoka T, Goto S, Oshima T, Mori H, Maeda
M, Wada C, Inokuchi H. HemK, a class of protein methyl transferase with
similarity to DNA methyl transferases, methylates polypeptide chain release
factors, and hemK knockout induces defects in translational termination. Proc
Natl Acad Sci U S A. 2002 Feb 5;99(3):1473-8. Epub 2002 Jan 22. PubMed PMID:
11805295; PubMed Central PMCID: PMC122215.

265: Qi Z, O'Brian MR. Interaction between the bacterial iron response regulator 
and ferrochelatase mediates genetic control of heme biosynthesis. Mol Cell. 2002 
Jan;9(1):155-62. PubMed PMID: 11804594.

266: Deybach JC. Porphyria. Painful photosensitivity. Lancet. 2001 Dec;358
Suppl:S49. PubMed PMID: 11784598.

267: Gouya L, Puy H, Robreau AM, Bourgeois M, Lamoril J, Da Silva V, Grandchamp
B, Deybach JC. The penetrance of dominant erythropoietic protoporphyria is
modulated by expression of wildtype FECH. Nat Genet. 2002 Jan;30(1):27-8. Epub
2001 Dec 20. PubMed PMID: 11753383.

268: Baysse C, Matthijs S, Pattery T, Cornelis P. Impact of mutations in hemA and
hemH genes on pyoverdine production by Pseudomonas fluorescens ATCC17400. FEMS
Microbiol Lett. 2001 Nov 27;205(1):57-63. PubMed PMID: 11728716.

269: Papenbrock J, Mishra S, Mock HP, Kruse E, Schmidt EK, Petersmann A, Braun
HP, Grimm B. Impaired expression of the plastidic ferrochelatase by antisense RNA
synthesis leads to a necrotic phenotype of transformed tobacco plants. Plant J.
2001 Oct;28(1):41-50. PubMed PMID: 11696185.

270: Papenbrock J, Grimm B. Regulatory network of tetrapyrrole
biosynthesis--studies of intracellular signalling involved in metabolic and
developmental control of plastids. Planta. 2001 Sep;213(5):667-81. Review. PubMed
PMID: 11678270.

271: Suzuki T, Masuda T, Singh DP, Tan FC, Tsuchiya T, Shimada H, Ohta H, Smith
AG, Takamiya K. Two types of ferrochelatase in photosynthetic and
nonphotosynthetic tissues of cucumber: their difference in phylogeny, gene
expression, and localization. J Biol Chem. 2002 Feb 15;277(7):4731-7. Epub 2001
Oct 23. PubMed PMID: 11675381.

272: Lister R, Chew O, Rudhe C, Lee MN, Whelan J. Arabidopsis thaliana
ferrochelatase-I and -II are not imported into Arabidopsis mitochondria. FEBS
Lett. 2001 Oct 12;506(3):291-5. PubMed PMID: 11602264.

273: Kobus SM, Wong SG, Marks GS. Isolation of regioisomers of
N-alkylprotoporphyrin IX from chick embryo liver after treatment with
porphyrinogenic xenobiotics. Can J Physiol Pharmacol. 2001 Sep;79(9):814-21.
PubMed PMID: 11599783.

274: Atamna H, Liu J, Ames BN. Heme deficiency selectively interrupts assembly of
mitochondrial complex IV in human fibroblasts: revelance to aging. J Biol Chem.
2001 Dec 21;276(51):48410-6. Epub 2001 Oct 11. PubMed PMID: 11598132.

275: Richard E, Mendez M, Mazurier F, Morel C, Costet P, Xia P, Fontanellas A,
Geronimi F, Cario-André M, Taine L, Ged C, Malik P, de Verneuil H, Moreau-Gaudry 
F. Gene therapy of a mouse model of protoporphyria with a self-inactivating
erythroid-specific lentiviral vector without preselection. Mol Ther. 2001
Oct;4(4):331-8. PubMed PMID: 11592836.

276: Almirón M, Martínez M, Sanjuan N, Ugalde RA. Ferrochelatase is present in
Brucella abortus and is critical for its intracellular survival and virulence.
Infect Immun. 2001 Oct;69(10):6225-30. PubMed PMID: 11553564; PubMed Central
PMCID: PMC98755.

277: Wang KF, Dailey TA, Dailey HA. Expression and characterization of the
terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus. FEMS 
Microbiol Lett. 2001 Aug 7;202(1):115-9. PubMed PMID: 11506917.

278: Sellers VM, Wu CK, Dailey TA, Dailey HA. Human ferrochelatase:
characterization of substrate-iron binding and proton-abstracting residues.
Biochemistry. 2001 Aug 21;40(33):9821-7. PubMed PMID: 11502175.

279: Wang W, Li R, Chen J. [Expression of transferrin receptor and ferrochelatase
mRNAs in MEL cells]. Zhonghua Xue Ye Xue Za Zhi. 1999 Jan;20(1):17-20. Chinese.
PubMed PMID: 11498837.

280: Li W, Zhang WJ, Ohnishi K, Yamada I, Ohno R, Hashimoto K. 5-Aminolaevulinic 
acid-mediated photodynamic therapy in multidrug resistant leukemia cells. J
Photochem Photobiol B. 2001 Jul;60(2-3):79-86. PubMed PMID: 11470562.

281: Leung YK, Ho JW. Purification and properties of ferrochelatase from
Chironomidae larvae. Mol Cell Biochem. 2001 Apr;220(1-2):161-7. PubMed PMID:
11451377.

282: Kharimov KhIa, Inoiatova FKh, Dolimova MA. [Changes in the activity of
enzymes of heme synthesis and catabolism, and level of microsomal hemoproteins
during the liver acute intoxication by thioacetamide]. Vopr Med Khim. 2001
Mar-Apr;47(2):243-7. Russian. PubMed PMID: 11450445.

283: Duwat P, Sourice S, Cesselin B, Lamberet G, Vido K, Gaudu P, Le Loir Y,
Violet F, Loubière P, Gruss A. Respiration capacity of the fermenting bacterium
Lactococcus lactis and its positive effects on growth and survival. J Bacteriol. 
2001 Aug;183(15):4509-16. PubMed PMID: 11443085; PubMed Central PMCID: PMC95345.

284: Yotsumoto S, Shimada S, Terasaki K, Taketani S, Kobayashi K, Saheki T,
Kanzaki T. A novel A(-4)-to-G acceptor splice site mutation leads to three bases 
insertion in ferrochelatase mRNA in a patient with erythropoietic protoporphyria.
J Invest Dermatol. 2001 Jul;117(1):159-61. PubMed PMID: 11442767.

285: Nihei C, Nakayashiki T, Nakamura K, Inokuchi H, Gennis RB, Kojima S, Kita K.
Abortive assembly of succinate-ubiquinone reductase (complex II) in a
ferrochelatase-deficient mutant of Escherichia coli. Mol Genet Genomics. 2001
May;265(3):394-404. PubMed PMID: 11405622.

286: Schubert HL, Raux E, Warren MJ, Wilson KS. Optimization of Met8p crystals
through protein-storage buffer manipulation. Acta Crystallogr D Biol Crystallogr.
2001 Jun;57(Pt 6):867-9. Epub 2001 May 25. PubMed PMID: 11375511.

287: Rüfenacht UB, Gregor A, Gouya L, Tarczynska-Nosal S, Schneider-Yin X,
Deybach JC. New missense mutation in the human ferrochelatase gene in a family
with erythropoietic protoporphyria: functional studies and correlation of
genotype and phenotype. Clin Chem. 2001 Jun;47(6):1112-3. PubMed PMID: 11375302.

288: Franco R, Pereira AS, Tavares P, Mangravita A, Barber MJ, Moura I, Ferreira 
GC. Substitution of murine ferrochelatase glutamate-287 with glutamine or alanine
leads to porphyrin substrate-bound variants. Biochem J. 2001 May 15;356(Pt
1):217-22. PubMed PMID: 11336654; PubMed Central PMCID: PMC1221830.

289: Fontanellas A, Mendez M, Mazurier F, Cario-André M, Navarro S, Ged C, Taine 
L, Géronimi F, Richard E, Moreau-Gaudry F, Enriquez De Salamanca R, de Verneuil
H. Successful therapeutic effect in a mouse model of erythropoietic
protoporphyria by partial genetic correction and fluorescence-based selection of 
hematopoietic cells. Gene Ther. 2001 Apr;8(8):618-26. PubMed PMID: 11320408.

290: Taketani S, Furukawa T, Furuyama K. Expression of coproporphyrinogen oxidase
and synthesis of hemoglobin in human erythroleukemia K562 cells. Eur J Biochem.
2001 Mar;268(6):1705-11. PubMed PMID: 11248690.

291: Meerman L. Erythropoietic protoporphyria. An overview with emphasis on the
liver. Scand J Gastroenterol Suppl. 2000;(232):79-85. Review. PubMed PMID:
11232498.

292: Dailey HA, Dailey TA, Wu CK, Medlock AE, Wang KF, Rose JP, Wang BC.
Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters.
Cell Mol Life Sci. 2000 Dec;57(13-14):1909-26. Review. PubMed PMID: 11215517.

293: Sharma DC, Mathur R. Some biochemical changes in heme synthesis in iron
deficiency. Indian J Physiol Pharmacol. 2000 Oct;44(4):491-4. PubMed PMID:
11214507.

294: Thunell S, Harper P, Brun A. Porphyrins, porphyrin metabolism and
porphyrias. IV. Pathophysiology of erythyropoietic protoporphyria--diagnosis,
care and monitoring of the patient. Scand J Clin Lab Invest. 2000
Nov;60(7):581-604. Review. PubMed PMID: 11202051.

295: Row PE, Gray JC. Chloroplast precursor proteins compete to form early import
intermediates in isolated pea chloroplasts. J Exp Bot. 2001 Jan;52(354):47-56.
PubMed PMID: 11181712.

296: Wu CK, Dailey HA, Rose JP, Burden A, Sellers VM, Wang BC. The 2.0 A
structure of human ferrochelatase, the terminal enzyme of heme biosynthesis. Nat 
Struct Biol. 2001 Feb;8(2):156-60. PubMed PMID: 11175906.

297: Bloks VW, Plösch T, van Goor H, Roelofsen H, Baller J, Havinga R, Verkade
HJ, van Tol A, Jansen PL, Kuipers F. Hyperlipidemia and atherosclerosis
associated with liver disease in ferrochelatase-deficient mice. J Lipid Res. 2001
Jan;42(1):41-50. PubMed PMID: 11160364.

298: van Den Boogert J, van Staveren HJ, de Bruin RWF, de Rooij FWM,
Edixhoven-Bosdijk A, Siersema PD, van Hillegersberg R. Fractionated illumination 
in oesophageal ALA-PDT: effect on ferrochelatase activity. J Photochem Photobiol 
B. 2000 Jun;56(1):53-60. PubMed PMID: 11073316.

299: Bartosová J, Hrkal Z. Accumulation of protoporphyrin-IX (PpIX) in leukemic
cell lines following induction by 5-aminolevulinic acid (ALA). Comp Biochem
Physiol C Toxicol Pharmacol. 2000 Jul;126(3):245-52. PubMed PMID: 11048674.

300: Schneider-Yin X, Gouya L, Meier-Weinand A, Deybach JC, Minder EI. New
insights into the pathogenesis of erythropoietic protoporphyria and their impact 
on patient care. Eur J Pediatr. 2000 Oct;159(10):719-25. Review. PubMed PMID:
11039124.

301: He Q, Dolganov N, Bjorkman O, Grossman AR. The high light-inducible
polypeptides in Synechocystis PCC6803. Expression and function in high light. J
Biol Chem. 2001 Jan 5;276(1):306-14. PubMed PMID: 11024039.

302: Tichy M, Vermaas W. Combinatorial mutagenesis and pseudorevertant analysis
to characterize regions in loop E of the CP47 protein in Synechocystis sp. PCC
6803. Eur J Biochem. 2000 Oct;267(20):6296-301. PubMed PMID: 11012684.

303: Barber M, Conrad ME, Umbreit JN, Barton JC, Moore EG. Abnormalities of
flavin monooxygenase as an etiology for sideroblastic anemia. Am J Hematol. 2000 
Oct;65(2):149-53. PubMed PMID: 10996833.

304: Childs S, Weinstein BM, Mohideen MA, Donohue S, Bonkovsky H, Fishman MC.
Zebrafish dracula encodes ferrochelatase and its mutation provides a model for
erythropoietic protoporphyria. Curr Biol. 2000 Aug 24;10(16):1001-4. PubMed PMID:
10985389.

305: Wong SG, Marks GS. Formation of N-alkylprotoporphyrin IX after interaction
of porphyrinogenic xenobiotics with rat liver microsomes. J Pharmacol Toxicol
Methods. 1999 Nov;42(3):107-13. PubMed PMID: 10964007.

306: Timonen K, Kariniemi AL, Niemi KM, Teppo AM, Tenhunen R, Kauppinen R.
Vascular changes in erythropoietic protoporphyria: histopathologic and
immunohistochemical study. J Am Acad Dermatol. 2000 Sep;43(3):489-97. PubMed
PMID: 10954661.

307: Krieg RC, Fickweiler S, Wolfbeis OS, Knuechel R. Cell-type specific
protoporphyrin IX metabolism in human bladder cancer in vitro. Photochem
Photobiol. 2000 Aug;72(2):226-33. PubMed PMID: 10946577.

308: Hinnen P, de Rooij FW, Terlouw EM, Edixhoven A, van Dekken H, van
Hillegersberg R, Tilanus HW, Wilson JH, Siersema PD. Porphyrin biosynthesis in
human Barrett's oesophagus and adenocarcinoma after ingestion of
5-aminolaevulinic acid. Br J Cancer. 2000 Aug;83(4):539-43. PubMed PMID:
10945504; PubMed Central PMCID: PMC2374652.

309: Schneider-Yin X, Gouya L, Dorsey M, Rüfenacht U, Deybach JC, Ferreira GC.
Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to 
erythropoietic protoporphyria. Blood. 2000 Aug 15;96(4):1545-9. PubMed PMID:
10942404.

310: Gamble JT, Wong SG, Dailey HA, Marks GS. Use of recombinant human
ferrochelatase as a sensitive bioassay for N-alkylprotoporphyrin IX formed after 
interaction of porphyrinogenic xenobiotics with rat liver microsomes. Can J
Physiol Pharmacol. 2000 Jul;78(7):578-81. PubMed PMID: 10926165.

311: Mathews-Roth MM. Erythropoietic protoporphyria: treatment with antioxidants 
and potential cure with gene therapy. Methods Enzymol. 2000;319:479-84. PubMed
PMID: 10907535.

312: Taketani S, Adachi Y, Nakahashi Y. Regulation of the expression of human
ferrochelatase by intracellular iron levels. Eur J Biochem. 2000
Aug;267(15):4685-92. PubMed PMID: 10903501.

313: Bloomer JR, Poh-Fitzpatrick MB. Theodore Woodward Award. Pathogenesis of
biochemical abnormalities in protoporphyria. Trans Am Clin Climatol Assoc.
2000;111:245-56; discussion 256-7. Review. PubMed PMID: 10881344; PubMed Central 
PMCID: PMC2194363.

314: Fontanellas A, Mazurier F, Landry M, Taine L, Morel C, Larou M, Daniel JY,
Montagutelli X, de Salamanca RE, de Verneuil H. Reversion of hepatobiliary
alterations By bone marrow transplantation in a murine model of erythropoietic
protoporphyria. Hepatology. 2000 Jul;32(1):73-81. PubMed PMID: 10869291.

315: Moretti MB, Garcia SC, Batlle A. Porphyrin biosynthesis intermediates are
not regulating delta-aminolevulinic acid transport in Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 2000 Jun 16;272(3):946-50. PubMed PMID: 10860855.

316: Medlock AE, Dailey HA. Examination of the activity of carboxyl-terminal
chimeric constructs of human and yeast ferrochelatases. Biochemistry. 2000 Jun
27;39(25):7461-7. PubMed PMID: 10858295.

317: Asano H, Li XS, Stamatoyannopoulos G. FKLF-2: a novel Krüppel-like
transcriptional factor that activates globin and other erythroid lineage genes.
Blood. 2000 Jun 1;95(11):3578-84. PubMed PMID: 10828046.

318: Magness ST, Tugores A, Brenner DA. Analysis of ferrochelatase expression
during hematopoietic development of embryonic stem cells. Blood. 2000 Jun
1;95(11):3568-77. PubMed PMID: 10828045.

319: Suzuki T, Masuda T, Inokuchi H, Shimada H, Ohta H, Takamiya K.
Overexpression, enzymatic properties and tissue localization of a ferrochelatase 
of cucumber. Plant Cell Physiol. 2000 Feb;41(2):192-9. PubMed PMID: 10795314.

320: Reid G. Association of sudden infant death syndrome with grossly deranged
iron metabolism and nitric oxide overload. Med Hypotheses. 2000 Jan;54(1):137-9. 
PubMed PMID: 10790739.

321: Doss MO, Kühnel A, Gross U. Alcohol and porphyrin metabolism. Alcohol
Alcohol. 2000 Mar-Apr;35(2):109-25. Review. PubMed PMID: 10787385.

322: Masuda T, Suzuki T, Takamiya K. [Metal chelatases involved in chlorophyll
and heme biosynthetic pathways in photosynthetic organisms]. Tanpakushitsu
Kakusan Koso. 2000 Apr;45(5):700-9. Review. Japanese. PubMed PMID: 10771597.

323: Schlör S, Herbert M, Rodenburg M, Blass J, Reidl J. Characterization of
ferrochelatase (hemH) mutations in Haemophilus influenzae. Infect Immun. 2000
May;68(5):3007-9. PubMed PMID: 10769004; PubMed Central PMCID: PMC97519.

324: Gamble JT, Dailey HA, Marks GS. N-Methylprotoporphyrin is a more potent
inhibitor of recombinant human than of recombinant chicken ferrochelatase. Drug
Metab Dispos. 2000 Apr;28(4):373-5. PubMed PMID: 10725301.

325: Lecerof D, Fodje M, Hansson A, Hansson M, Al-Karadaghi S. Structural and
mechanistic basis of porphyrin metallation by ferrochelatase. J Mol Biol. 2000
Mar 17;297(1):221-32. PubMed PMID: 10704318.

326: Franco R, Ma JG, Lu Y, Ferreira GC, Shelnutt JA. Porphyrin interactions with
wild-type and mutant mouse ferrochelatase. Biochemistry. 2000 Mar
14;39(10):2517-29. PubMed PMID: 10704201.

327: Muppala V, Lin CS, Lee YH. The role of HNF-1alpha in controlling hepatic
catalase activity. Mol Pharmacol. 2000 Jan;57(1):93-100. PubMed PMID: 10617683.

328: Labbé RF, Vreman HJ, Stevenson DK. Zinc protoporphyrin: A metabolite with a 
mission. Clin Chem. 1999 Dec;45(12):2060-72. Review. PubMed PMID: 10585337.

329: Ferreira GC. Ferrochelatase. Int J Biochem Cell Biol. 1999
Oct;31(10):995-1000. Review. PubMed PMID: 10582332.

330: Burden AE, Wu C, Dailey TA, Busch JL, Dhawan IK, Rose JP, Wang B, Dailey HA.
Human ferrochelatase: crystallization, characterization of the [2Fe-2S] cluster
and determination that the enzyme is a homodimer. Biochim Biophys Acta. 1999 Nov 
16;1435(1-2):191-7. PubMed PMID: 10561552.

331: Gibson SL, Nguyen ML, Havens JJ, Barbarin A, Hilf R. Relationship of
delta-aminolevulinic acid-induced protoporphyrin IX levels to mitochondrial
content in neoplastic cells in vitro. Biochem Biophys Res Commun. 1999 Nov
19;265(2):315-21. PubMed PMID: 10558864.

332: Jacobs JM, Marek D, Walton HS, Sinclair PR, Sinclair JF. Effect of sodium
arsenite on heme metabolism in cultured chick embryo hepatocytes. Arch Biochem
Biophys. 1999 Nov 1;371(1):8-14. PubMed PMID: 10525283.

333: Bhasin G, Kausar H, Athar M. Ferrochelatase, a novel target for photodynamic
therapy of cancer. Oncol Rep. 1999 Nov-Dec;6(6):1439-42. PubMed PMID: 10523727.

334: Meerman L, Koopen NR, Bloks V, Van Goor H, Havinga R, Wolthers BG, Kramer W,
Stengelin S, Müller M, Kuipers F, Jansen PL. Biliary fibrosis associated with
altered bile composition in a mouse model of erythropoietic protoporphyria.
Gastroenterology. 1999 Sep;117(3):696-705. PubMed PMID: 10464147.

335: Schubert HL, Raux E, Wilson KS, Warren MJ. Common chelatase design in the
branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis.
Biochemistry. 1999 Aug 17;38(33):10660-9. PubMed PMID: 10451360.

336: Frank J, Nelson J, Wang X, Yang L, Ahmad W, Lam H, Jugert FK, Kalka K,
Poh-Fitzpatrick MB, Goerz G, Merk HF, Christiano AM. Erythropoietic
protoporphyria: identification of novel mutations in the ferrochelatase gene and 
comparison of biochemical markers versus molecular analysis as diagnostic
strategies. J Investig Med. 1999 Jul;47(6):278-84. PubMed PMID: 10431482.

337: Wang X, Yang L, Kurtz L, Lichtin A, DeLeo VA, Bloomer J, Poh-Fitzpatrick MB.
Haplotype analysis of families with erythropoietic protoporphyria and novel
mutations of the ferrochelatase gene. J Invest Dermatol. 1999 Jul;113(1):87-92.
PubMed PMID: 10417624.

338: Funk C, Vermaas W. A cyanobacterial gene family coding for single-helix
proteins resembling part of the light-harvesting proteins from higher plants.
Biochemistry. 1999 Jul 20;38(29):9397-404. PubMed PMID: 10413515.

339: Asokumar B, Kierney C, James TW, Amato J, Tumanmd KJ. Anaesthetic management
of a patient with erythropoietic protoporphyria for ventricular septal defect
closure. Paediatr Anaesth. 1999;9(4):356-8. PubMed PMID: 10411776.

340: Pawliuk R, Bachelot T, Wise RJ, Mathews-Roth MM, Leboulch P. Long-term cure 
of the photosensitivity of murine erythropoietic protoporphyria by preselective
gene therapy. Nat Med. 1999 Jul;5(7):768-73. PubMed PMID: 10395321.

341: Lange H, Kispal G, Lill R. Mechanism of iron transport to the site of heme
synthesis inside yeast mitochondria. J Biol Chem. 1999 Jul 2;274(27):18989-96.
PubMed PMID: 10383398.

342: Branda SS, Yang ZY, Chew A, Isaya G. Mitochondrial intermediate peptidase
and the yeast frataxin homolog together maintain mitochondrial iron homeostasis
in Saccharomyces cerevisiae. Hum Mol Genet. 1999 Jun;8(6):1099-110. PubMed PMID: 
10332043.

343: Wang KF, Wu CK, Sellers VM, Rose JP, Wang BC, Dailey HA. Purification,
crystallization and preliminary X-ray analysis of Drosophila melanogaster
ferrochelatase. Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1201-3.
PubMed PMID: 10329785.

344: Inafuku K, Takamiyagi A, Oshiro M, Kinjo T, Nakashima Y, Nonaka S.
Alteration of mRNA levels of delta-aminolevulinic acid synthase, ferrochelatase
and heme oxygenase-1 in griseofulvin induced protoporphyria mice. J Dermatol Sci.
1999 Apr;19(3):189-98. PubMed PMID: 10215191.

345: Asano H, Li XS, Stamatoyannopoulos G. FKLF, a novel Krüppel-like factor that
activates human embryonic and fetal beta-like globin genes. Mol Cell Biol. 1999
May;19(5):3571-9. PubMed PMID: 10207080; PubMed Central PMCID: PMC84149.

346: Reichheld JH, Katz E, Banner BF, Szymanski IO, Saltzman JR, Bonkovsky HL.
The value of intravenous heme-albumin and plasmapheresis in reducing
postoperative complications of orthotopic liver transplantation for
erythropoietic protoporphyria. Transplantation. 1999 Mar 27;67(6):922-8. PubMed
PMID: 10199745.

347: Lin F, Geiger PG, Korytowski W, Girotti AW. Protoporphyrin IX-sensitized
photoinactivation of 5-aminolevulinate-treated leukemia cells: effects of
exogenous iron. Photochem Photobiol. 1999 Mar;69(3):375-81. PubMed PMID:
10089831.

348: Braun J. Erythrocyte zinc protoporphyrin. Kidney Int Suppl. 1999
Mar;69:S57-60. Review. PubMed PMID: 10084287.

349: Födinger M, Sunder-Plassmann G. Inherited disorders of iron metabolism.
Kidney Int Suppl. 1999 Mar;69:S22-34. Review. PubMed PMID: 10084283.

350: Gouya L, Puy H, Lamoril J, Da Silva V, Grandchamp B, Nordmann Y, Deybach JC.
Inheritance in erythropoietic protoporphyria: a common wild-type ferrochelatase
allelic variant with low expression accounts for clinical manifestation. Blood.
1999 Mar 15;93(6):2105-10. PubMed PMID: 10068685.

351: Raux E, McVeigh T, Peters SE, Leustek T, Warren MJ. The role of
Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis. 
Biochem J. 1999 Mar 15;338 ( Pt 3):701-8. PubMed PMID: 10051442; PubMed Central
PMCID: PMC1220106.

352: van den Boogert J, Houtsmuller AB, de Rooij FW, de Bruin RW, Siersema PD,
van Hillegersberg R. Kinetics, localization, and mechanism of 5-aminolevulinic
acid-induced porphyrin accumulation in normal and Barrett's-like rat esophagus.
Lasers Surg Med. 1999;24(1):3-13. PubMed PMID: 10037346.

353: Taketani S, Mohri T, Hioki K, Tokunaga R, Kohno H. Structure and
transcriptional regulation of the mouse ferrochelatase gene. Gene. 1999 Feb
18;227(2):117-24. PubMed PMID: 10023040.

354: Magness ST, Brenner DA. Targeted disruption of the mouse ferrochelatase gene
producing an exon 10 deletion. Biochim Biophys Acta. 1999 Jan 6;1453(1):161-74.
PubMed PMID: 9989256.

355: Todd DJ. Clinical implications of the molecular biology of erythropoietic
protoporphyria. J Eur Acad Dermatol Venereol. 1998 Nov;11(3):207-13. Review.
PubMed PMID: 9883431.

356: Góra M, Rytka J, Labbe-Bois R. Activity and cellular location in
Saccharomyces cerevisiae of chimeric mouse/yeast and Bacillus subtilis/yeast
ferrochelatases. Arch Biochem Biophys. 1999 Jan 15;361(2):231-40. PubMed PMID:
9882451.

357: Taira MC, San Martín de Viale LC. Effect of lindane and heptachlor on
delta-aminolaevulinate synthase and its regulation. Arch Toxicol. 1998
Nov;72(11):722-30. PubMed PMID: 9879810.

358: Iwama H, Iwase O, Hayashi S, Nakano M, Toyama K. [Macrocytic anemia with
anisocytosis due to alcohol abuse and vitamin B6 deficiency]. Rinsho Ketsueki.
1998 Nov;39(11):1127-30. Japanese. PubMed PMID: 9866426.

359: Rüfenacht UB, Schneider-Yin X, Schäfer BW, Taketani S, Deybach JC, Minder
EI. Rapid molecular diagnosis of erythropoietic protoporphyria among Swiss
patients. Clin Chem Lab Med. 1998 Oct;36(10):763-5. PubMed PMID: 9853802.

360: Taketani S, Adachi Y, Kohno H, Ikehara S, Tokunaga R, Ishii T. Molecular
characterization of a newly identified heme-binding protein induced during
differentiation of urine erythroleukemia cells. J Biol Chem. 1998 Nov
20;273(47):31388-94. PubMed PMID: 9813049.

361: Day AL, Parsons BM, Dailey HA. Cloning and characterization of Gallus and
Xenopus ferrochelatases: presence of the [2Fe-2S] cluster in nonmammalian
ferrochelatase. Arch Biochem Biophys. 1998 Nov 15;359(2):160-9. PubMed PMID:
9808757.

362: Jenkins MM, LeBoeuf RD, Ruth GR, Bloomer JR. A novel stop codon mutation
(X417L) of the ferrochelatase gene in bovine protoporphyria, a natural animal
model of the human disease. Biochim Biophys Acta. 1998 Oct 22;1408(1):18-24.
PubMed PMID: 9784594.

363: Turner PC, Thomas CE, Elkins C, Clary S, Sparling PF. Neisseria gonorrhoeae 
heme biosynthetic mutants utilize heme and hemoglobin as a heme source but fail
to grow within epithelial cells. Infect Immun. 1998 Nov;66(11):5215-23. PubMed
PMID: 9784525; PubMed Central PMCID: PMC108651.

364: Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG,
Stevens RC. Structural and kinetic evidence for strain in biological catalysis.
Biochemistry. 1998 Oct 13;37(41):14404-9. PubMed PMID: 9772166.

365: Chow KS, Singh DP, Walker AR, Smith AG. Two different genes encode
ferrochelatase in Arabidopsis: mapping, expression and subcellular targeting of
the precursor proteins. Plant J. 1998 Aug;15(4):531-41. PubMed PMID: 9753778.

366: Hinnen P, de Rooij FW, van Velthuysen ML, Edixhoven A, van Hillegersberg R, 
Tilanus HW, Wilson JH, Siersema PD. Biochemical basis of 5-aminolaevulinic
acid-induced protoporphyrin IX accumulation: a study in patients with
(pre)malignant lesions of the oesophagus. Br J Cancer. 1998 Sep;78(5):679-82.
PubMed PMID: 9744510; PubMed Central PMCID: PMC2063052.

367: Remenyik E, Lanyon GW, Horkay I, Paragh G, Wikonkál N, Kósa A, Moore MR.
Erythropoietic protoporphyria: a new mutation responsible for exon skipping in
the human ferrochelatase gene. J Invest Dermatol. 1998 Sep;111(3):540-1. PubMed
PMID: 9740256.

368: Gouya L, Schneider-Yin X, Rüfenacht U, Herrero C, Lecha M, Mascaro JM, Puy
H, Deybach JC, Minder EI. Mutations in the ferrochelatase gene of four Spanish
patients with erythropoietic protoporphyria. J Invest Dermatol. 1998
Sep;111(3):406-9. PubMed PMID: 9740232.

369: Sellers VM, Wang KF, Johnson MK, Dailey HA. Evidence that the fourth ligand 
to the [2Fe-2S] cluster in animal ferrochelatase is a cysteine. Characterization 
of the enzyme from Drosophila melanogaster. J Biol Chem. 1998 Aug
28;273(35):22311-6. PubMed PMID: 9712849.

370: Wong SG, Kobus SM, McNamee JP, Marks GS. Gender differences in N-alkyl
protoporphyrin IX production in rats after the administration of porphyrinogenic 
xenobiotics. Drug Metab Dispos. 1998 Aug;26(8):739-44. PubMed PMID: 9698287.

371: Muzyka V, Veimer S, Schmidt N. On the carcinogenic risk evaluation of diesel
exhaust: benzene in airborne particles and alterations of heme metabolism in
lymphocytes as markers of exposure. Sci Total Environ. 1998 Jun
30;217(1-2):103-11. PubMed PMID: 9695175.

372: Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S, Brenner D. Molecular
defects in ferrochelatase in patients with protoporphyria requiring liver
transplantation. J Clin Invest. 1998 Jul 1;102(1):107-14. PubMed PMID: 9649563;
PubMed Central PMCID: PMC509071.

373: Kondo M, Yano Y. [Erythropoietic protoporphyria]. Ryoikibetsu Shokogun
Shirizu. 1998;(19 Pt 2):155-7. Review. Japanese. PubMed PMID: 9645031.

374: Yano Y, Kondo M. [Introduction to porphyrin and heme]. Ryoikibetsu Shokogun 
Shirizu. 1998;(19 Pt 2):123-35. Review. Japanese. PubMed PMID: 9645023.

375: Magness ST, Tugores A, Diala ES, Brenner DA. Analysis of the human
ferrochelatase promoter in transgenic mice. Blood. 1998 Jul 1;92(1):320-8. PubMed
PMID: 9639532.

376: Todd DJ. Molecular genetics of erythropoietic protoporphyria. Photodermatol 
Photoimmunol Photomed. 1998 Apr;14(2):70-3. Review. PubMed PMID: 9638728.

377: Sellers VM, Dailey TA, Dailey HA. Examination of ferrochelatase mutations
that cause erythropoietic protoporphyria. Blood. 1998 May 15;91(10):3980-5.
PubMed PMID: 9573038.

378: Rüfenacht UB, Gouya L, Schneider-Yin X, Puy H, Schäfer BW, Aquaron R,
Nordmann Y, Minder EI, Deybach JC. Systematic analysis of molecular defects in
the ferrochelatase gene from patients with erythropoietic protoporphyria. Am J
Hum Genet. 1998 Jun;62(6):1341-52. PubMed PMID: 9585598; PubMed Central PMCID:
PMC1377149.

379: Jacobs JM, Sinclair PR, Sinclair JF, Gorman N, Walton HS, Wood SG, Nichols
C. Formation of zinc protoporphyrin in cultured hepatocytes: effects of
ferrochelatase inhibition, iron chelation or lead. Toxicology. 1998 Feb
6;125(2-3):95-105. PubMed PMID: 9570325.

380: Cox TM, Alexander GJ, Sarkany RP. Protoporphyria. Semin Liver Dis.
1998;18(1):85-93. Review. PubMed PMID: 9516682.

381: Srivastava P, Pandey VC. Heme synthesizing enzymes of Plasmodium knowlesi: a
simian malaria parasite. Exp Parasitol. 1998 Jan;88(1):60-3. PubMed PMID:
9501849.

382: Pearce DA, Page MD, Norris HA, Tomlinson EJ, Ferguson SJ. Identification of 
the contiguous Paracoccus denitrificans ccmF and ccmH genes: disruption of ccmF, 
encoding a putative transporter, results in formation of an unstable
apocytochrome c and deficiency in siderophore production. Microbiology. 1998
Feb;144 ( Pt 2):467-77. PubMed PMID: 9493384.

383: Al-Karadaghi S, Hansson M, Nikonov S, Jönsson B, Hederstedt L. Crystal
structure of ferrochelatase: the terminal enzyme in heme biosynthesis. Structure.
1997 Nov 15;5(11):1501-10. PubMed PMID: 9384565.

384: Gibson SL, Cupriks DJ, Havens JJ, Nguyen ML, Hilf R. A regulatory role for
porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid
(delta-ALA)-induced photosensitization? Br J Cancer. 1998;77(2):235-42. PubMed
PMID: 9460994; PubMed Central PMCID: PMC2151216.

385: Blackwood ME Jr, Rush TS 3rd, Romesberg F, Schultz PG, Spiro TG. Alternative
modes of substrate distortion in enzyme and antibody catalyzed ferrochelation
reactions. Biochemistry. 1998 Jan 20;37(3):779-82. PubMed PMID: 9457047.

386: Shenefelt PD. Fetal detoxification of maternal protoporphyria. J Am Acad
Dermatol. 1998 Jan;38(1):129-30. PubMed PMID: 9448224.

387: Martini CN, Vaena de Avalos SG, Romero DG, San Martín de Viale L, Vila Mde
C. Heme availability affects corticosterone and aldosterone biosynthesis in rat
adrenal. Steroids. 1997 Dec;62(12):767-70. PubMed PMID: 9434340.

388: Walker CJ, Willows RD. Mechanism and regulation of Mg-chelatase. Biochem J. 
1997 Oct 15;327 ( Pt 2):321-33. Review. PubMed PMID: 9359397; PubMed Central
PMCID: PMC1218797.

389: Wang X, Piomelli S, Peacocke M, Christiano AM, Poh-Fitzpatrick MB.
Erythropoietic protoporphyria: four novel frameshift mutations in the
ferrochelatase gene. J Invest Dermatol. 1997 Nov;109(5):688-91. PubMed PMID:
9347801.

390: Knasmüller S, Parzefall W, Helma C, Kassie F, Ecker S, Schulte-Hermann R.
Toxic effects of griseofulvin: disease models, mechanisms, and risk assessment.
Crit Rev Toxicol. 1997 Sep;27(5):495-537. Review. Erratum in: Crit Rev Toxicol
1998 Jan;28(1):102. PubMed PMID: 9347226.

391: Chow KS, Singh DP, Roper JM, Smith AG. A single precursor protein for
ferrochelatase-I from Arabidopsis is imported in vitro into both chloroplasts and
mitochondria. J Biol Chem. 1997 Oct 31;272(44):27565-71. PubMed PMID: 9346891.

392: Bonday ZQ, Taketani S, Gupta PD, Padmanaban G. Heme biosynthesis by the
malarial parasite. Import of delta-aminolevulinate dehydrase from the host red
cell. J Biol Chem. 1997 Aug 29;272(35):21839-46. PubMed PMID: 9268315.

393: Abels C, Fritsch C, Bolsen K, Szeimies RM, Ruzicka T, Goerz G, Goetz AE.
Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an
amelanotic melanoma in vivo. J Photochem Photobiol B. 1997 Aug;40(1):76-83.
PubMed PMID: 9301046.

394: Tan WC, Krasner N, O'Toole P, Lombard M. Enhancement of photodynamic therapy
in gastric cancer cells by removal of iron. Gut. 1997 Jul;41(1):14-8. PubMed
PMID: 9274465; PubMed Central PMCID: PMC1027221.

395: Agaba MK, Kemp SJ, Barendse W, Teale A. Comparative mapping in cattle of
genes located on human chromosome 18. Mamm Genome. 1997 Jul;8(7):530-2. PubMed
PMID: 9196003.

396: Cox TM. Erythropoietic protoporphyria. J Inherit Metab Dis. 1997
Jun;20(2):258-69. Review. PubMed PMID: 9211198.

397: Srivastava P, Sharma GD, Kamboj KK, Rastogi AK, Pandey VC. Heme metabolism
in promastigotes of Leishmania donovani. Mol Cell Biochem. 1997
Jun;171(1-2):65-8. PubMed PMID: 9201697.

398: Roper JM, Smith AG. Molecular localisation of ferrochelatase in higher plant
chloroplasts. Eur J Biochem. 1997 May 15;246(1):32-7. PubMed PMID: 9210462.

399: Li Y, Sen D. Toward an efficient DNAzyme. Biochemistry. 1997 May
6;36(18):5589-99. PubMed PMID: 9154943.

400: Cochón AC, Aldonatti C, San Martín de Viale LC, Wainstok de Calmanovici R.
Evaluation of the porphyrinogenic risk of antineoplastics. J Appl Toxicol. 1997
May-Jun;17(3):171-7. PubMed PMID: 9250538.

401: Furukawa T, Tokunaga R, Taketani S. Regulation of the ferrochelatase gene
expression during differentiation of mouse erythroleukemia cells. Biochem Mol
Biol Int. 1997 May;41(6):1161-70. PubMed PMID: 9161711.

402: Hashimoto Y, Yamashita M, Murooka Y. The Propionibacterium freudenreichii
hemYHBXRL gene cluster, which encodes enzymes and a regulator involved in the
biosynthetic pathway from glutamate to protoheme. Appl Microbiol Biotechnol. 1997
Apr;47(4):385-92. PubMed PMID: 9163953.

403: Hansson M, Gough SP, Brody SS. Structure prediction and fold recognition for
the ferrochelatase family of proteins. Proteins. 1997 Apr;27(4):517-22. PubMed
PMID: 9141132.

404: Nagai M, Nagai T, Yamamoto M, Goto K, Bishop TR, Hayashi N, Kondo H, Seyama 
Y, Kano K, Fujita H, Sassa S. Novel regulation of delta-aminolevulinate synthase 
in the rat harderian gland. Biochem Pharmacol. 1997 Mar 7;53(5):643-50. PubMed
PMID: 9113083.

405: Smith AG, Clothier B, Francis JE, Gibbs AH, De Matteis F, Hider RC.
Protoporphyria induced by the orally active iron chelator
1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn mice. Blood. 1997 Feb
1;89(3):1045-51. PubMed PMID: 9028337.

406: Hansen J, Muldbjerg M, Chérest H, Surdin-Kerjan Y. Siroheme biosynthesis in 
Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes.
FEBS Lett. 1997 Jan 13;401(1):20-4. PubMed PMID: 9003798.

407: Di Francesco V, Geetha V, Garnier J, Munson PJ. Fold recognition using
predicted secondary structure sequences and hidden Markov models of protein
folds. Proteins. 1997;Suppl 1:123-8. PubMed PMID: 9485503.

408: Rice DW, Fischer D, Weiss R, Eisenberg D. Fold assignments for amino acid
sequences of the CASP2 experiment. Proteins. 1997;Suppl 1:113-22. PubMed PMID:
9485502.

409: Sellers VM, Dailey HA. Expression, purification, and characterization of
recombinant mammalian ferrochelatase. Methods Enzymol. 1997;281:378-87. PubMed
PMID: 9251003.

410: Salonpää P, Kottari S, Pelkonen O, Raunio H. Regulation of CYP 2 A 5
induction by porphyrinogenic agents in mouse primary hepatocytes. Naunyn
Schmiedebergs Arch Pharmacol. 1997 Jan;355(1):8-13. PubMed PMID: 9007836.

411: McNicholas PM, Javor G, Darie S, Gunsalus RP. Expression of the heme
biosynthetic pathway genes hemCD, hemH, hemM, and hemA of Escherichia coli. FEMS 
Microbiol Lett. 1997 Jan 1;146(1):143-8. PubMed PMID: 8997718.

412: Crouse BR, Sellers VM, Finnegan MG, Dailey HA, Johnson MK. Site-directed
mutagenesis and spectroscopic characterization of human ferrochelatase:
identification of residues coordinating the [2Fe-2S] cluster. Biochemistry. 1996 
Dec 17;35(50):16222-9. PubMed PMID: 8973195.

413: García-Vargas GG, Hernández-Zavala A. Urinary porphyrins and heme
biosynthetic enzyme activities measured by HPLC in arsenic toxicity. Biomed
Chromatogr. 1996 Nov-Dec;10(6):278-84. Review. PubMed PMID: 8949908.

414: Glerum DM, Shtanko A, Tzagoloff A, Gorman N, Sinclair PR. Cloning and
identification of HEM14, the yeast gene for mitochondrial protoporphyrinogen
oxidase. Yeast. 1996 Nov;12(14):1421-5. PubMed PMID: 8948097.

415: He D, Behar S, Roberts JE, Lim HW. The effect of L-cysteine and
N-acetylcysteine on porphyrin/heme biosynthetic pathway in cells treated with
5-aminolevulinic acid and exposed to radiation. Photodermatol Photoimmunol
Photomed. 1996 Oct;12(5):194-9. PubMed PMID: 9112277.

416: Berg K, Anholt H, Bech O, Moan J. The influence of iron chelators on the
accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells. Br J
Cancer. 1996 Sep;74(5):688-97. PubMed PMID: 8795569; PubMed Central PMCID:
PMC2074689.

417: Wang X. Molecular characterization of a novel defect occurring de novo
associated with erythropoietic protoporphyria. Biochim Biophys Acta. 1996 Aug
23;1316(3):149-52. PubMed PMID: 8781532.

418: McNamee JP, Kobus SM, Marks GS. The apoprotein of cytochrome P450 3A2 does
not selectively direct alkylation to one of four pyrrole rings of
N-vinylprotoporphyrin IX. Can J Physiol Pharmacol. 1996 Aug;74(8):996-1000.
PubMed PMID: 8960390.

419: Imoto S, Tanizawa Y, Sato Y, Kaku K, Oka Y. A novel mutation in the
ferrochelatase gene associated with erythropoietic protoporphyria. Br J Haematol.
1996 Jul;94(1):191-7. PubMed PMID: 8757534.

420: Gora M, Grzybowska E, Rytka J, Labbe-Bois R. Probing the active-site
residues in Saccharomyces cerevisiae ferrochelatase by directed mutagenesis. In
vivo and in vitro analyses. J Biol Chem. 1996 May 17;271(20):11810-6. PubMed
PMID: 8662602.

421: Goerz G, Bunselmeyer S, Bolsen K, Schürer NY. Ferrochelatase activities in
patients with erythropoietic protoporphyria and their families. Br J Dermatol.
1996 May;134(5):880-5. PubMed PMID: 8736329.

422: Gibson LC, Marrison JL, Leech RM, Jensen PE, Bassham DC, Gibson M, Hunter
CN. A putative Mg chelatase subunit from Arabidopsis thaliana cv C24. Sequence
and transcript analysis of the gene, import of the protein into chloroplasts, and
in situ localization of the transcript and protein. Plant Physiol. 1996
May;111(1):61-71. PubMed PMID: 8685276; PubMed Central PMCID: PMC157813.

423: Meissner PN, Dailey TA, Hift RJ, Ziman M, Corrigall AV, Roberts AG, Meissner
DM, Kirsch RE, Dailey HA. A R59W mutation in human protoporphyrinogen oxidase
results in decreased enzyme activity and is prevalent in South Africans with
variegate porphyria. Nat Genet. 1996 May;13(1):95-7. PubMed PMID: 8673113.

424: Huang JL, Zaider E, Roth P, Garcia O, Pollack S, Poh-Fitzpatrick MB.
Congenital erythropoietic porphyria: clinical, biochemical, and enzymatic profile
of a severely affected infant. J Am Acad Dermatol. 1996 May;34(5 Pt 2):924-7.
PubMed PMID: 8621830.

425: Kanazireva E, Biel AJ. Nucleotide sequence of the Rhodobacter capsulatus
hemH gene. Gene. 1996 Apr 17;170(1):149-50. PubMed PMID: 8621079.

426: Kimmett SM, Whitney RA, Marks GS. Isolation of N-vinylprotoporphyrin IX
after hepatic cytochrome P450 inactivation by 3-[(arylthio)ethyl]sydnone in chick
embryos pretreated with phenobarbital, glutethimide, dexamethasone, and
beta-naphthoflavone: differential inhibition of ferrochelatase by
N-vinylprotoporphyrin regioisomers. Mol Pharmacol. 1996 Apr;49(4):676-82. PubMed 
PMID: 8609896.

427: Yang H, Sasarman A, Inokuchi H, Adler J. Non-iron porphyrins cause tumbling 
to blue light by an Escherichia coli mutant defective in hemG. Proc Natl Acad Sci
U S A. 1996 Mar 19;93(6):2459-63. PubMed PMID: 8637896; PubMed Central PMCID:
PMC39819.

428: Beukeveld GJ, In 't Veld G, Havinga R, Groen AK, Wolthers BG, Kuipers F.
Relationship between biliary lipid and protoporphyrin secretion; potential role
of mdr2 P-glycoprotein in hepatobiliary organic anion transport. J Hepatol. 1996 
Mar;24(3):343-52. PubMed PMID: 8778203.

429: Sarkany RP, Cox TM. Liver failure in erythropoietic protoporphyria. J Am
Acad Dermatol. 1996 Mar;34(3):540-1. PubMed PMID: 8609281.

430: Sellers VM, Johnson MK, Dailey HA. Function of the [2FE-2S] cluster in
mammalian ferrochelatase: a possible role as a nitric oxide sensor. Biochemistry.
1996 Feb 27;35(8):2699-704. PubMed PMID: 8611576.

431: Malakhov M, Wada H, Los D, Murata N. The coxD gene for heme O synthase in
Synechocystis. Biochim Biophys Acta. 1996 Feb 15;1273(2):84-6. PubMed PMID:
8611593.

432: Takeda Y, Sawada H, Tashima M, Okuma M, Kondo M. Erythropoietic
protoporphyria without cutaneous photosensitivity and with ringed sideroblasts in
an atomic bomb survivor. Lancet. 1996 Feb 10;347(8998):395-6. PubMed PMID:
8598718.

433: Takamiyagi A, Nakashima Y, Irifune H, Uezato H, Nonaka S. Quantitative
analysis of ferrochelatase mRNA in blood cells of erythropoietic protoporphyria
patients. J Dermatol Sci. 1996 Feb;11(2):154-60. PubMed PMID: 8869037.

434: Henriksson M, Timonen K, Mustajoki P, Pihlaja H, Tenhunen R, Peltonen L,
Kauppinen R. Four novel mutations in the ferrochelatase gene among erythropoietic
protoporphyria patients. J Invest Dermatol. 1996 Feb;106(2):346-50. PubMed PMID: 
8601739.

435: Gouya L, Deybach JC, Lamoril J, Da Silva V, Beaumont C, Grandchamp B,
Nordmann Y. Modulation of the phenotype in dominant erythropoietic protoporphyria
by a low expression of the normal ferrochelatase allele. Am J Hum Genet. 1996
Feb;58(2):292-9. PubMed PMID: 8571955; PubMed Central PMCID: PMC1914527.

436: Ríos de Molina MC, Iglesias S, Lauría L, San Martín de Viale LC.
Precancerous pathology evoked by hexachlorobenzene treatment. Acta Physiol
Pharmacol Ther Latinoam. 1996;46(2):71-81. PubMed PMID: 8998371.

437: De Matteis F, Marks GS. Cytochrome P450 and its interactions with the heme
biosynthetic pathway. Can J Physiol Pharmacol. 1996 Jan;74(1):1-8. Review. PubMed
PMID: 8963944.

438: Philippot V, Bérard F, Perrot H. [Homozygote erythropoietic protoporphyria
associated with porokeratosis]. Ann Dermatol Venereol. 1996;123(6-7):382-6.
French. PubMed PMID: 8959061.

439: Góra M, Chaciñska A, Rytka J, Labbe-Bois R. Isolation and functional
characterization of mutant ferrochelatases in Saccharomyces cerevisiae.
Biochimie. 1996;78(2):144-52. PubMed PMID: 8818224.

440: Hansson M, Al-Karadaghi S. Purification, crystallization, and preliminary
X-ray analysis of Bacillus subtilis ferrochelatase. Proteins. 1995
Dec;23(4):607-9. PubMed PMID: 8749860.

441: Jacobs JM, Jacobs NJ. Terminal enzymes of heme biosynthesis in the plant
plasma membrane. Arch Biochem Biophys. 1995 Nov 10;323(2):274-8. PubMed PMID:
7487088.

442: Franco R, Moura JJ, Moura I, Lloyd SG, Huynh BH, Forbes WS, Ferreira GC.
Characterization of the iron-binding site in mammalian ferrochelatase by kinetic 
and Mössbauer methods. J Biol Chem. 1995 Nov 3;270(44):26352-7. PubMed PMID:
7592847.

443: Kanazireva E, Biel AJ. Cloning and overexpression of the Rhodobacter
capsulatus hemH gene. J Bacteriol. 1995 Nov;177(22):6693-4. PubMed PMID: 7592455;
PubMed Central PMCID: PMC177530.

444: Magness ST, Brenner DA. Ferrochelatase cDNA delivered by adenoviral vector
corrects biochemical defect in protoporphyric cells. Hum Gene Ther. 1995
Oct;6(10):1285-90. PubMed PMID: 8590732.

445: Ferreira GC. Ferrochelatase binds the iron-responsive element present in the
erythroid 5-aminolevulinate synthase mRNA. Biochem Biophys Res Commun. 1995 Sep
25;214(3):875-8. PubMed PMID: 7575558.

446: Furukawa T, Kohno H, Tokunaga R, Taketani S. Nitric oxide-mediated
inactivation of mammalian ferrochelatase in vivo and in vitro: possible
involvement of the iron-sulphur cluster of the enzyme. Biochem J. 1995 Sep 1;310 
( Pt 2):533-8. PubMed PMID: 7544575; PubMed Central PMCID: PMC1135927.

447: Shibuya H, Nonneman D, Tamassia M, Allphin OL, Johnson GS. The coding
sequence of the bovine ferrochelatase gene. Biochim Biophys Acta. 1995 Aug
15;1231(1):117-20. PubMed PMID: 7640290.

448: Prasad AR, Dailey HA. Effect of cellular location on the function of
ferrochelatase. J Biol Chem. 1995 Aug 4;270(31):18198-200. PubMed PMID: 7629135.

449: Sarkany RP, Cox TM. Autosomal recessive erythropoietic protoporphyria: a
syndrome of severe photosensitivity and liver failure. QJM. 1995 Aug;88(8):541-9.
PubMed PMID: 7648240.

450: Yang H, Inokuchi H, Adler J. Phototaxis away from blue light by an
Escherichia coli mutant accumulating protoporphyrin IX. Proc Natl Acad Sci U S A.
1995 Aug 1;92(16):7332-6. PubMed PMID: 7638191; PubMed Central PMCID: PMC41333.

451: Meguro K, Igarashi K, Yamamoto M, Fujita H, Sassa S. The role of the
erythroid-specific delta-aminolevulinate synthase gene expression in erythroid
heme synthesis. Blood. 1995 Aug 1;86(3):940-8. PubMed PMID: 7620186.

452: Saiki K. [Discovery of heme O and heme A synthases]. Seikagaku. 1995
Aug;67(8):1048-53. Review. Japanese. PubMed PMID: 7594873.

453: Henderson CA, Jones S, Elder G, Ilchyshyn A. Erythropoietic protoporphyria
presenting in an adult. J R Soc Med. 1995 Aug;88(8):476P-477P. Review. PubMed
PMID: 7562835; PubMed Central PMCID: PMC1295309.

454: Wang X, Poh-Fitzpatrick M, Chen T, Malavade K, Carriero D, Piomelli S.
Systematic screening for RNA with skipped exons--splicing mutations of the
ferrochelatase gene. Biochim Biophys Acta. 1995 Jun 9;1271(2-3):358-62. PubMed
PMID: 7541650.

455: Loeb MR. Ferrochelatase activity and protoporphyrin IX utilization in
Haemophilus influenzae. J Bacteriol. 1995 Jun;177(12):3613-5. PubMed PMID:
7768877; PubMed Central PMCID: PMC177073.

456: Miura T. [Erythropoietic protoporphyria]. Nippon Rinsho. 1995
Jun;53(6):1438-42. Review. Japanese. PubMed PMID: 7616660.

457: Taketani S, Yoshinaga T, Furukawa T, Kohno H, Tokunaga R, Nishimura K,
Inokuchi H. Induction of terminal enzymes for heme biosynthesis during
differentiation of mouse erythroleukemia cells. Eur J Biochem. 1995 Jun
1;230(2):760-5. PubMed PMID: 7607249.

458: He D, Behar S, Nomura N, Sassa S, Lim HW. The effect of ALA and radiation on
porphyrin/heme biosynthesis in endothelial cells. Photochem Photobiol. 1995
Jun;61(6):656-61. PubMed PMID: 7568413.

459: van Hillegersberg R, Hekking-Weijma JM, Wilson JH, Edixhoven-Bosdijk A, Kort
WJ. Adjuvant intraoperative photodynamic therapy diminishes the rate of local
recurrence in a rat mammary tumour model. Br J Cancer. 1995 Apr;71(4):733-7.
PubMed PMID: 7710937; PubMed Central PMCID: PMC2033744.

460: Mathews-Roth MM, Michel JL, Wise RJ. Amelioration of the metabolic defect in
erythropoietic protoporphyria by expression of human ferrochelatase in cultured
cells. J Invest Dermatol. 1995 Apr;104(4):497-9. PubMed PMID: 7706765.

461: Schneider-Yin X, Schäfer BW, Tönz O, Minder EI. Human ferrochelatase: a
novel mutation in patients with erythropoietic protoporphyria and an isoform
caused by alternative splicing. Hum Genet. 1995 Apr;95(4):391-6. PubMed PMID:
7705834.

462: Thunell S, Andersson C, Carlmark B, Floderus Y, Grönqvist SO, Harper P,
Henrichson A, Lindh U. Markers for vulnerability in acute porphyria. A hypothesis
paper. Eur J Clin Chem Clin Biochem. 1995 Apr;33(4):179-94. PubMed PMID: 7626691.

463: Taketani S, Fujita H. The ferrochelatase gene structure and molecular
defects associated with erythropoietic protoporphyria. J Bioenerg Biomembr. 1995 
Apr;27(2):231-8. Review. PubMed PMID: 7592570.

464: Ferreira GC, Franco R, Lloyd SG, Moura I, Moura JJ, Huynh BH. Structure and 
function of ferrochelatase. J Bioenerg Biomembr. 1995 Apr;27(2):221-9. Review.
PubMed PMID: 7592569.

465: Salonpää P, Krause K, Pelkonen O, Raunio H. Up-regulation of CYP2A5
expression by porphyrinogenic agents in mouse liver. Naunyn Schmiedebergs Arch
Pharmacol. 1995 Apr;351(4):446-52. PubMed PMID: 7543189.

466: Kim YM, Bergonia HA, Müller C, Pitt BR, Watkins WD, Lancaster JR Jr. Loss
and degradation of enzyme-bound heme induced by cellular nitric oxide synthesis. 
J Biol Chem. 1995 Mar 17;270(11):5710-3. PubMed PMID: 7890697.

467: Sattler I, Roessner CA, Stolowich NJ, Hardin SH, Harris-Haller LW,
Yokubaitis NT, Murooka Y, Hashimoto Y, Scott AI. Cloning, sequencing, and
expression of the uroporphyrinogen III methyltransferase cobA gene of
Propionibacterium freudenreichii (shermanii). J Bacteriol. 1995
Mar;177(6):1564-9. PubMed PMID: 7883713; PubMed Central PMCID: PMC176773.

468: Taketani S. [Diversity of the terminal enzymes for heme biosynthesis].
Seikagaku. 1995 Mar;67(3):233-7. Review. Japanese. PubMed PMID: 7602200.

469: He D, Behar S, Nomura N, Sassa S, Taketani S, Lim HW. The effect of
porphyrin and radiation on ferrochelatase and 5-aminolevulinic acid synthase in
epidermal cells. Photodermatol Photoimmunol Photomed. 1995 Feb;11(1):25-30.
PubMed PMID: 7654564.

470: Ostasiewicz LT, Huang JL, Wang X, Piomelli S, Poh-Fitzpatrick MB. Human
protoporphyria: genetic heterogeneity at the ferrochelatase locus. Photodermatol 
Photoimmunol Photomed. 1995 Feb;11(1):18-21. PubMed PMID: 7654562.

471: Woodard SI, Dailey HA. Regulation of heme biosynthesis in Escherichia coli. 
Arch Biochem Biophys. 1995 Jan 10;316(1):110-5. PubMed PMID: 7840603.

472: Kim YM, Bergonia HA, Müller C, Pitt BR, Watkins WD, Lancaster JR Jr. Nitric 
oxide and intracellular heme. Adv Pharmacol. 1995;34:277-91. Review. PubMed PMID:
8562440.

473: Fuchs O. Iron-responsive element-binding protein mRNA levels during
erythroid differentiation of murine erythroleukemia cells. Neoplasma.
1995;42(4):179-85. PubMed PMID: 7659183.

474: Roelandts R. Photo(chemo)therapy and general management of erythropoietic
protoporphyria. Dermatology. 1995;190(4):330-1. PubMed PMID: 7655119.

475: Tugores A, Magness ST, Brenner DA. A single promoter directs both
housekeeping and erythroid preferential expression of the human ferrochelatase
gene. J Biol Chem. 1994 Dec 9;269(49):30789-97. PubMed PMID: 7983009.

476: May A, Fitzsimons E. Sideroblastic anaemia. Baillieres Clin Haematol. 1994
Dec;7(4):851-79. Review. PubMed PMID: 7881157.

477: Todd DJ. Erythropoietic protoporphyria. Br J Dermatol. 1994
Dec;131(6):751-66. Review. PubMed PMID: 7857832.

478: Jordan PM. Highlights in haem biosynthesis. Curr Opin Struct Biol. 1994
Dec;4(6):902-11. Review. PubMed PMID: 7712294.

479: Kohno H, Okuda M, Furukawa T, Tokunaga R, Taketani S. Site-directed
mutagenesis of human ferrochelatase: identification of histidine-263 as a binding
site for metal ions. Biochim Biophys Acta. 1994 Nov 16;1209(1):95-100. PubMed
PMID: 7947988.

480: Wang X, Poh-Fitzpatrick M, Piomelli S. A novel splicing mutation in the
ferrochelatase gene responsible for erythropoietic protoporphyria. Biochim
Biophys Acta. 1994 Oct 21;1227(1-2):25-7. PubMed PMID: 7918679.

481: Cable EE, Pepe JA, Donohue SE, Lambrecht RW, Bonkovsky HL. Effects of
mifepristone (RU-486) on heme metabolism and cytochromes P-450 in cultured chick 
embryo liver cells, possible implications for acute porphyria. Eur J Biochem.
1994 Oct 15;225(2):651-7. PubMed PMID: 7957180.

482: Houston T, Moore MR, McColl KE, Fitzsimons EJ. Regulation of haem
biosynthesis in normoblastic erythropoiesis: role of 5-aminolaevulinic acid
synthase and ferrochelatase. Biochim Biophys Acta. 1994 Sep 28;1201(1):85-93.
PubMed PMID: 7918587.

483: Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor 
EW, Brenner DA. Deletion of the ferrochelatase gene in a patient with
protoporphyria. Hum Mol Genet. 1994 Sep;3(9):1695-7. PubMed PMID: 7833934.

484: Srivastava P, Puri SK, Pandey VC. Effect of Plasmodium berghei infection and
antimalarial treatment on heme synthesis in mice. Int J Parasitol. 1994
Aug;24(5):677-9. PubMed PMID: 7928069.

485: Schneider-Yin X, Taketani S, Schäfer B, Minder EI. Recessive inheritance of 
erythropoietic protoporphyria with liver failure. Lancet. 1994 Jul
30;344(8918):337. PubMed PMID: 7914284.

486: Goerz G, Bolsen K, Bunselmeyer S, Schürer NY. Recessive inheritance of
erythropoietic protoporphyria with liver failure. Lancet. 1994 Jul
30;344(8918):337. PubMed PMID: 7914283.

487: Okuda M, Kohno H, Furukawa T, Tokunaga R, Taketani S. Overexpression in
Escherichia coli, and one-step purification of the human recombinant
ferrochelatase. Biochim Biophys Acta. 1994 Jul 6;1200(2):123-8. PubMed PMID:
8031831.

488: Iinuma S, Farshi SS, Ortel B, Hasan T. A mechanistic study of cellular
photodestruction with 5-aminolaevulinic acid-induced porphyrin. Br J Cancer. 1994
Jul;70(1):21-8. Erratum in: Br J Cancer 1994 Dec;70(6):1283. PubMed PMID:
8018536; PubMed Central PMCID: PMC2033301.

489: Sarkany RP, Alexander GJ, Cox TM. Recessive inheritance of erythropoietic
protoporphyria with liver failure. Lancet. 1994 Jun 4;343(8910):1394-6. PubMed
PMID: 7910885.

490: Miyamoto K, Tanaka R, Teramoto H, Masuda T, Tsuji H, Inokuchi H. Nucleotide 
sequences of cDNA clones encoding ferrochelatase from barley and cucumber. Plant 
Physiol. 1994 Jun;105(2):769-70. PubMed PMID: 8066144; PubMed Central PMCID:
PMC159427.

491: Schneider-Yin X, Schäfer BW, Möhr P, Burg G, Minder EI. Molecular defects in
erythropoietic protoporphyria with terminal liver failure. Hum Genet. 1994
Jun;93(6):711-3. PubMed PMID: 8005600.

492: Mamet R, Teitz Y, Schoenfeld N. Transformation, growth rate, and the heme
biosynthetic pathway in V-abl-transfected fibroblasts. Biochem Med Metab Biol.
1994 Jun;52(1):53-7. PubMed PMID: 7917467.

493: Matringe M, Camadro JM, Joyard J, Douce R. Localization of ferrochelatase
activity within mature pea chloroplasts. J Biol Chem. 1994 May
27;269(21):15010-5. PubMed PMID: 8195137.

494: Smith AG, Santana MA, Wallace-Cook AD, Roper JM, Labbe-Bois R. Isolation of 
a cDNA encoding chloroplast ferrochelatase from Arabidopsis thaliana by
functional complementation of a yeast mutant. J Biol Chem. 1994 May
6;269(18):13405-13. PubMed PMID: 8175771.

495: Sarkany RP, Whitcombe DM, Cox TM. Molecular characterization of a
ferrochelatase gene defect causing anomalous RNA splicing in erythropoietic
protoporphyria. J Invest Dermatol. 1994 Apr;102(4):481-4. PubMed PMID: 8151124.

496: Whitcombe DM, Albertson DG, Cox TM. Molecular analysis of functional and
nonfunctional genes for human ferrochelatase: isolation and characterization of a
FECH pseudogene and its sublocalization on chromosome 3. Genomics. 1994
Apr;20(3):482-6. PubMed PMID: 8034322.

497: Taketani S, Kohno H, Okuda M, Furukawa T, Tokunaga R. Induction of
peripheral-type benzodiazepine receptors during differentiation of mouse
erythroleukemia cells. A possible involvement of these receptors in heme
biosynthesis. J Biol Chem. 1994 Mar 11;269(10):7527-31. PubMed PMID: 8125973.

498: Ferreira GC, Franco R, Lloyd SG, Pereira AS, Moura I, Moura JJ, Huynh BH.
Mammalian ferrochelatase, a new addition to the metalloenzyme family. J Biol
Chem. 1994 Mar 11;269(10):7062-5. PubMed PMID: 8125912.

499: Houston T, Moore M, Porter D, Sturrock R, Fitzsimons E. Abnormal haem
biosynthesis in the chronic anaemia of rheumatoid arthritis. Ann Rheum Dis. 1994 
Mar;53(3):167-70. PubMed PMID: 8154933; PubMed Central PMCID: PMC1005280.

500: Miyamoto K, Kanaya S, Morikawa K, Inokuchi H. Overproduction, purification, 
and characterization of ferrochelatase from Escherichia coli. J Biochem. 1994
Mar;115(3):545-51. PubMed PMID: 8056770.

501: Hansson M, Hederstedt L. Purification and characterisation of a
water-soluble ferrochelatase from Bacillus subtilis. Eur J Biochem. 1994 Feb
15;220(1):201-8. PubMed PMID: 8119288.

502: Ferreira GC. Mammalian ferrochelatase. Overexpression in Escherichia coli as
a soluble protein, purification and characterization. J Biol Chem. 1994 Feb
11;269(6):4396-400. Erratum in: J Biol Chem 1994 Apr 1;269(13):10184. PubMed
PMID: 8308010.

503: Lim HW, Behar S, He D. Effect of porphyrin and irradiation on heme
biosynthetic pathway in endothelial cells. Photodermatol Photoimmunol Photomed.
1994 Feb;10(1):17-21. PubMed PMID: 8180096.

504: Dailey HA, Finnegan MG, Johnson MK. Human ferrochelatase is an iron-sulfur
protein. Biochemistry. 1994 Jan 18;33(2):403-7. PubMed PMID: 8286370.

505: Wang X, Poh-Fitzpatrick M, Taketani S, Chen T, Piomelli S. Screening for
ferrochelatase mutations: molecular heterogeneity of erythropoietic
protoporphyria. Biochim Biophys Acta. 1994 Jan 11;1225(2):187-90. PubMed PMID:
8280787.

506: Dailey HA, Sellers VM, Dailey TA. Mammalian ferrochelatase. Expression and
characterization of normal and two human protoporphyric ferrochelatases. J Biol
Chem. 1994 Jan 7;269(1):390-5. PubMed PMID: 8276824.

507: Saiki K, Mogi T, Ogura K, Anraku Y. In vitro heme O synthesis by the cyoE
gene product from Escherichia coli. J Biol Chem. 1993 Dec 15;268(35):26041-4.
PubMed PMID: 8253713.

508: Rank JM, Carithers R, Bloomer J. Evidence for neurological dysfunction in
end-stage protoporphyric liver disease. Hepatology. 1993 Dec;18(6):1404-9. PubMed
PMID: 8244265.

509: Fukuda Y, Fujita H, Taketani S, Sassa S. Haem is necessary for a continued
increase in ferrochelatase mRNA in murine erythroleukaemia cells during erythroid
differentiation. Br J Haematol. 1993 Dec;85(4):670-5. PubMed PMID: 7918029.

510: Brady AM, Hasmall RL, Elcombe BM, Lock EA, De Matteis F. Effects of
2-[1-(ethoxyimino)propyl]-3-hydroxy-5-(2,4,6-trimethylphenyl) cyclohex-2-enone on
hepatic haem biosynthesis: species differences in hepatic porphyria. Toxicology. 
1993 Nov 12;84(1-3):199-215. PubMed PMID: 8266338.

511: Lake-Bullock H, Dailey HA. Biphasic ordered induction of heme synthesis in
differentiating murine erythroleukemia cells: role of erythroid 5-aminolevulinate
synthase. Mol Cell Biol. 1993 Nov;13(11):7122-32. PubMed PMID: 8413301; PubMed
Central PMCID: PMC364773.

512: Mercurio MG, Prince G, Weber FL Jr, Jacobs G, Zaim MT, Bickers DR. Terminal 
hepatic failure in erythropoietic protoporphyria. J Am Acad Dermatol. 1993
Nov;29(5 Pt 2):829-33. PubMed PMID: 8408820.

513: Kohno H, Furukawa T, Yoshinaga T, Tokunaga R, Taketani S. Coproporphyrinogen
oxidase. Purification, molecular cloning, and induction of mRNA during erythroid 
differentiation. J Biol Chem. 1993 Oct 5;268(28):21359-63. PubMed PMID: 8407975.

514: Todd DJ, Hughes AE, Ennis KT, Ward AJ, Burrows D, Nevin NC. Identification
of a single base pair deletion (40 del G) in exon 1 of the ferrochelatase gene in
patients with erythropoietic protoporphyria. Hum Mol Genet. 1993 Sep;2(9):1495-6.
PubMed PMID: 8242081.

515: Ostasiewicz LT, Fleischman J, Poh-Fitzpatrick MB. Distribution of
ferrochelatase activity in density gradient separated bone marrow cells. Anal
Biochem. 1993 Sep;213(2):395-9. PubMed PMID: 8238916.

516: Taketani S. Molecular and genetic characterization of ferrochelatase. Tohoku
J Exp Med. 1993 Sep;171(1):1-20. Review. PubMed PMID: 8122254.

517: Frustaci JM, O'Brian MR. Analysis of the Bradyrhizobium japonicum hemH gene 
and its expression in Escherichia coli. Appl Environ Microbiol. 1993
Aug;59(8):2347-51. PubMed PMID: 8368826; PubMed Central PMCID: PMC182289.

518: Cozza EN, Vila MC, Gomez-Sanchez CE. Stimulation of aldosterone production
by hemin in calf adrenal glomerulosa cell cultures. Steroids. 1993
Aug;58(8):384-6. PubMed PMID: 8212089.

519: Chang E, Welch S, Luna J, Giacalone J, Francke U. Generation of a human
chromosome 18-specific YAC clone collection and mapping of 55 unique YACs by FISH
and fingerprinting. Genomics. 1993 Aug;17(2):393-402. PubMed PMID: 7691716.

520: Nakahashi Y, Miyazaki H, Kadota Y, Naitoh Y, Inoue K, Yamamoto M, Hayashi N,
Taketani S. Human erythropoietic protoporphyria: identification of a mutation at 
the splice donor site of intron 7 causing exon 7 skipping of the ferrochelatase
gene. Hum Mol Genet. 1993 Jul;2(7):1069-70. PubMed PMID: 8364548.

521: Proulx KL, Woodard SI, Dailey HA. In situ conversion of coproporphyrinogen
to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway. 
Protein Sci. 1993 Jul;2(7):1092-8. PubMed PMID: 8358292; PubMed Central PMCID:
PMC2142421.

522: Chan RY, Schulman HM, Ponka P. Expression of ferrochelatase mRNA in
erythroid and non-erythroid cells. Biochem J. 1993 Jun 1;292 ( Pt 2):343-9.
PubMed PMID: 8503869; PubMed Central PMCID: PMC1134215.

523: Whitcombe DM, Cox TM. Dinucleotide repeat polymorphism at the locus for
human ferrochelatase (FECH). Hum Mol Genet. 1993 Jun;2(6):826. PubMed PMID:
8353511.

524: Boulechfar S, Lamoril J, Montagutelli X, Guenet JL, Deybach JC, Nordmann Y, 
Dailey H, Grandchamp B, de Verneuil H. Ferrochelatase structural mutant
(Fechm1Pas) in the house mouse. Genomics. 1993 Jun;16(3):645-8. PubMed PMID:
8325637.

525: Nakahashi Y, Miyazaki H, Kadota Y, Naitoh Y, Inoue K, Yamamoto M, Hayashi N,
Taketani S. Molecular defect in human erythropoietic protoporphyria with fatal
liver failure. Hum Genet. 1993 May;91(4):303-6. PubMed PMID: 8500787.

526: He D, Sassa S, Lim HW. Effect of UVA and blue light on porphyrin
biosynthesis in epidermal cells. Photochem Photobiol. 1993 May;57(5):825-9.
PubMed PMID: 8337255.

527: Ponka P, Schulman HM. Regulation of heme biosynthesis: distinct regulatory
features in erythroid cells. Stem Cells. 1993 May;11 Suppl 1:24-35. Review.
PubMed PMID: 8318916.

528: Fuchs O. Ferrochelatase, glutathione peroxidase and transferrin receptor
mRNA synthesis and levels in mouse erythroleukemia cells. Stem Cells. 1993 May;11
Suppl 1:13-23. PubMed PMID: 8318915.

529: Wang X, Poh-Fitzpatrick M, Carriero D, Ostasiewicz L, Chen T, Taketani S,
Piomelli S. A novel mutation in erythropoietic protoporphyria: an aberrant
ferrochelatase mRNA caused by exon skipping during RNA splicing. Biochim Biophys 
Acta. 1993 Apr 30;1181(2):198-200. PubMed PMID: 8481408.

530: Abbas A, Labbe-Bois R. Structure-function studies of yeast ferrochelatase.
Identification and functional analysis of amino acid substitutions that increase 
Vmax and the KM for both substrates. J Biol Chem. 1993 Apr 25;268(12):8541-6.
PubMed PMID: 8473299.

531: Peters LL, Andrews NC, Eicher EM, Davidson MB, Orkin SH, Lux SE. Mouse
microcytic anaemia caused by a defect in the gene encoding the globin
enhancer-binding protein NF-E2. Nature. 1993 Apr 22;362(6422):768-70. Erratum in:
Nature 1994 Sep 22;371(6495):358. PubMed PMID: 8469289.

532: Frustaci JM, O'Brian MR. The Escherichia coli visA gene encodes
ferrochelatase, the final enzyme of the heme biosynthetic pathway. J Bacteriol.
1993 Apr;175(7):2154-6. PubMed PMID: 8458858; PubMed Central PMCID: PMC204334.

533: Mitani K, Fujita H, Fukuda Y, Kappas A, Sassa S. The role of inorganic
metals and metalloporphyrins in the induction of haem oxygenase and heat-shock
protein 70 in human hepatoma cells. Biochem J. 1993 Mar 15;290 ( Pt 3):819-25.
PubMed PMID: 8384446; PubMed Central PMCID: PMC1132355.

534: Havelund T, Fenger C. [Liver disease in erythropoietic protoporphyria].
Ugeskr Laeger. 1993 Mar 8;155(10):697-700. Danish. PubMed PMID: 8456510.

535: Fukuda Y, Fujita H, Taketani S, Sassa S. Dimethyl sulphoxide and haemin
induce ferrochelatase mRNA by different mechanisms in murine erythroleukaemia
cells. Br J Haematol. 1993 Mar;83(3):480-4. PubMed PMID: 8485055.

536: Hansson M, von Wachenfeldt C. Heme b (protoheme IX) is a precursor of heme a
and heme d in Bacillus subtilis. FEMS Microbiol Lett. 1993 Feb 15;107(1):121-5.
PubMed PMID: 8467994.

537: Rademakers LH, Koningsberger JC, Sorber CW, Baart de la Faille H, Van Hattum
J, Marx JJ. Accumulation of iron in erythroblasts of patients with erythropoietic
protoporphyria. Eur J Clin Invest. 1993 Feb;23(2):130-8. PubMed PMID: 8462622.

538: Doss MO, Frank M, Sieg I. [Cholestatic erythrohepatic protoporphyria:
porphyrin metabolism before and after liver transplantation]. Z Gastroenterol.
1993 Feb;31 Suppl 2:85-9. Review. German. PubMed PMID: 7483727.

539: Frater Y, Brady A, Lock EA, De Matteis F. Formation of N-methyl
protoporphyrin in chemically-induced protoporphyria. Studies with a novel
porphyrogenic agent. Arch Toxicol. 1993;67(3):179-85. PubMed PMID: 8494497.

540: He D, Karas E, Sassa S, Lim HW. Porphyrin synthesis by murine epidermal
cells. Skin Pharmacol. 1993;6(1):20-5. PubMed PMID: 8489770.

541: Rossi E, Taketani S, Garcia-Webb P. Lead and the terminal mitochondrial
enzymes of haem biosynthesis. Biomed Chromatogr. 1993 Jan-Feb;7(1):1-6. Review.
PubMed PMID: 8431673.

542: Kondo M, Hirota N, Takaoka T, Kajiwara M. Heme-biosynthetic enzyme
activities and porphyrin accumulation in normal liver and hepatoma cell lines of 
rat. Cell Biol Toxicol. 1993 Jan-Mar;9(1):95-105. PubMed PMID: 8390914.

543: Padmaja K, Prasad AR. Selenium altered regulation of heme biosynthesis in
chick embryos. Drug Chem Toxicol. 1993;16(4):395-408. PubMed PMID: 8281892.

544: Fuchs O. [Ferrochelatase gene expression in erythroid cells]. Cas Lek Cesk. 
1992 Dec 4;131(24-25):741-5. Czech. PubMed PMID: 1288876.

545: Hansson M, Hederstedt L. Cloning and characterization of the Bacillus
subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes. J 
Bacteriol. 1992 Dec;174(24):8081-93. PubMed PMID: 1459957; PubMed Central PMCID: 
PMC207547.

546: Bijlmer-Iest JC, Baart de la Faille H, van Asbeck BS, van Hattum J, van
Weelden H, Marx JJ, Koningsberger JC. Protoporphyrin photosensitivity cannot be
attenuated by oral N-acetylcysteine. Photodermatol Photoimmunol Photomed.
1992-1993 Dec;9(6):245-9. PubMed PMID: 1343225.

547: Miyamoto K, Nishimura K, Masuda T, Tsuji H, Inokuchi H. Accumulation of
protoporphyrin IX in light-sensitive mutants of Escherichia coli. FEBS Lett. 1992
Oct 5;310(3):246-8. PubMed PMID: 1397280.

548: Cantoni L, Rizzardini M, Skorupska M, Cagnotto A, Codegoni A, Pecora N,
Frigo L, Ferrarese C, Mennini T. Hepatic protoporphyria is associated with a
decrease in ligand binding for the mitochondrial benzodiazepine receptors in the 
liver. Biochem Pharmacol. 1992 Sep 25;44(6):1159-64. PubMed PMID: 1329761.

549: Kimmett SM, Marks GS. Thin-layer chromatographic separation of the
ferrochelatase-inhibitory ring A and ring B regioisomers of N-ethylprotoporphyrin
from a mixture of the four regioisomers. J Pharmacol Toxicol Methods. 1992
Sep;28(2):113-7. PubMed PMID: 1482786.

550: Kitajima H, Kaneko T, Akatsuka J. [The measurement of erythrocyte zinc
protoporphyrin/heme ratio in various anemias in childhood]. Rinsho Ketsueki. 1992
Sep;33(9):1199-203. Japanese. PubMed PMID: 1433941.

551: Lim HW, Cooper D, Sassa S, Dosik H, Buchness MR, Soter NA. Photosensitivity,
abnormal porphyrin profile, and sideroblastic anemia. J Am Acad Dermatol. 1992
Aug;27(2 Pt 2):287-92. Review. PubMed PMID: 1517489.

552: Kimmett SM, Whitney RA, Marks GS. Evidence for the stereoselective
inhibition of chick embryo hepatic ferrochelatase by N-alkylated porphyrins. II. 
Mol Pharmacol. 1992 Aug;42(2):307-10. PubMed PMID: 1513328.

553: McCluskey SA, Riddick DS, Mackie JE, Kimmett SM, Whitney RA, Marks GS.
Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 
3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and
4-dodecyl substituents. Can J Physiol Pharmacol. 1992 Aug;70(8):1069-74. PubMed
PMID: 1473038.

554: Van Hillegersberg R, Van den Berg JW, Kort WJ, Terpstra OT, Wilson JH.
Selective accumulation of endogenously produced porphyrins in a liver metastasis 
model in rats. Gastroenterology. 1992 Aug;103(2):647-51. PubMed PMID: 1386052.

555: Frustaci JM, O'Brian MR. Characterization of a Bradyrhizobium japonicum
ferrochelatase mutant and isolation of the hemH gene. J Bacteriol. 1992
Jul;174(13):4223-9. PubMed PMID: 1624416; PubMed Central PMCID: PMC206202.

556: Brenner DA, Didier JM, Frasier F, Christensen SR, Evans GA, Dailey HA. A
molecular defect in human protoporphyria. Am J Hum Genet. 1992 Jun;50(6):1203-10.
PubMed PMID: 1376018; PubMed Central PMCID: PMC1682545.

557: Taketani S, Inazawa J, Nakahashi Y, Abe T, Tokunaga R. Structure of the
human ferrochelatase gene. Exon/intron gene organization and location of the gene
to chromosome 18. Eur J Biochem. 1992 Apr 1;205(1):217-22. PubMed PMID: 1555582.

558: el-Sharabasy MM, el-Waseef AM, Hafez MM, Salim SA. Porphyrin metabolism in
some malignant diseases. Br J Cancer. 1992 Mar;65(3):409-12. PubMed PMID:
1558795; PubMed Central PMCID: PMC1977583.

559: Eldridge MG, Dailey HA. Yeast ferrochelatase: expression in a baculovirus
system and purification of the expression protein. Protein Sci. 1992
Feb;1(2):271-7. PubMed PMID: 1304908; PubMed Central PMCID: PMC2142192.

560: Nakahashi Y, Fujita H, Taketani S, Ishida N, Kappas A, Sassa S. The
molecular defect of ferrochelatase in a patient with erythropoietic
protoporphyria. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):281-5. PubMed PMID:
1729699; PubMed Central PMCID: PMC48220.

561: Brady AM, Lock EA. Inhibition of ferrochelatase and accumulation of
porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.
Arch Toxicol. 1992;66(3):175-81. PubMed PMID: 1497480.

562: Cánepa ET, Pereda MP, Llambías EB, Grinstein M. Regulation of
phenobarbital-induced ferrochelatase mRNA activity by dibutyryl cAMP and glucose 
in normal and diabetic rat hepatocytes. Biochem Cell Biol. 1992 Jan;70(1):26-33. 
PubMed PMID: 1316128.

563: Straka JG, Bloomer JR, Kempner ES. The functional size of ferrochelatase
determined in situ by radiation inactivation. J Biol Chem. 1991 Dec
25;266(36):24637-41. PubMed PMID: 1761561.

564: Lamoril J, Boulechfar S, de Verneuil H, Grandchamp B, Nordmann Y, Deybach
JC. Human erythropoietic protoporphyria: two point mutations in the
ferrochelatase gene. Biochem Biophys Res Commun. 1991 Dec 16;181(2):594-9. PubMed
PMID: 1755842.

565: Wyss PA, Carter BE, Boynton SB, Connor E, Fowler B, Roth KS. Renal heme
metabolism in hereditary tyrosinemia: use of succinylacetone in rat renal
tubules. Biochim Biophys Acta. 1991 Dec 9;1070(2):300-4. PubMed PMID: 1764448.

566: Nakahigashi K, Nishimura K, Miyamoto K, Inokuchi H. Photosensitivity of a
protoporphyrin-accumulating, light-sensitive mutant (visA) of Escherichia coli
K-12. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10520-4. PubMed PMID: 1835790; 
PubMed Central PMCID: PMC52960.

567: Whitcombe DM, Carter NP, Albertson DG, Smith SJ, Rhodes DA, Cox TM.
Assignment of the human ferrochelatase gene (FECH) and a locus for protoporphyria
to chromosome 18q22. Genomics. 1991 Dec;11(4):1152-4. PubMed PMID: 1783383.

568: Gardner LC, Smith SJ, Cox TM. Biosynthesis of delta-aminolevulinic acid and 
the regulation of heme formation by immature erythroid cells in man. J Biol Chem.
1991 Nov 15;266(32):22010-8. PubMed PMID: 1939222.

569: Schelcher F, Delverdier M, Bezille P, Cabanie P, Espinasse J. Observation on
bovine congenital erythrocytic protoporphyria in the blonde d'Aquitaine breed.
Vet Rec. 1991 Nov 2;129(18):403-7. PubMed PMID: 1767483.

570: Tutois S, Montagutelli X, Da Silva V, Jouault H, Rouyer-Fessard P,
Leroy-Viard K, Guénet JL, Nordmann Y, Beuzard Y, Deybach JC. Erythropoietic
protoporphyria in the house mouse. A recessive inherited ferrochelatase
deficiency with anemia, photosensitivity, and liver disease. J Clin Invest. 1991 
Nov;88(5):1730-6. PubMed PMID: 1939658; PubMed Central PMCID: PMC295715.

571: Krueger BA, Trakshel GM, Sluss PM, Maines MD. Cyclosporin-mediated
depression of luteinizing hormone receptors and heme biosynthesis in rat testes: 
a possible mechanism for decrease in serum testosterone. Endocrinology. 1991
Nov;129(5):2647-54. PubMed PMID: 1935794.

572: Wainstok de Calmanovici R, Cochón AC, Aldonatti C, Cabral JR, San Martín de 
Viale LC. Sex comparison of heme pathway in rats bearing hepatic tumors. Tumori. 
1991 Oct 31;77(5):379-84. PubMed PMID: 1781034.

573: Punekar NS, Gokhale RS. Factors influencing the stability of heme and
ferrochelatase: role of oxygen. Biotechnol Appl Biochem. 1991 Aug;14(1):21-9.
PubMed PMID: 1910584.

574: Mackie JE, Back DW, Hamilton JW, Marks GS. Elevation of delta-aminolevulinic
acid synthase and cytochrome PB1 P450 messenger RNA levels by dihydropyridines,
dihydroquinolines, sydnones, and N-ethylprotoporphyrin IX. Biochem Pharmacol.
1991 Jul 15;42(3):475-83. PubMed PMID: 1859461.

575: Wainstok de Calmanovici R, Cochón AC, Zenklusen JC, Aldonatti C, Cabral JR, 
San Martín de Viale LC. Influence of hepatic tumors caused by diethylnitrosamine 
on hexachlorobenzene-induced porphyria in rats. Cancer Lett. 1991 Jul
4;58(3):225-32. PubMed PMID: 1649694.

576: Miyamoto K, Nakahigashi K, Nishimura K, Inokuchi H. Isolation and
characterization of visible light-sensitive mutants of Escherichia coli K12. J
Mol Biol. 1991 Jun 5;219(3):393-8. PubMed PMID: 2051480.

577: Guo R, Lim CK, Peters TJ. High-performance liquid chromatographic assays for
protoporphyrinogen oxidase and ferrochelatase in human leucocytes. J Chromatogr. 
1991 May 31;566(2):383-96. PubMed PMID: 1939451.

578: Conder LH, Woodard SI, Dailey HA. Multiple mechanisms for the regulation of 
haem synthesis during erythroid cell differentiation. Possible role for
coproporphyrinogen oxidase. Biochem J. 1991 Apr 15;275 ( Pt 2):321-6. PubMed
PMID: 2025219; PubMed Central PMCID: PMC1150055.

579: Walker CJ, Weinstein JD. Further Characterization of the Magnesium Chelatase
in Isolated Developing Cucumber Chloroplasts : Substrate Specificity, Regulation,
Intactness, and ATP Requirements. Plant Physiol. 1991 Apr;95(4):1189-1196. PubMed
PMID: 16668110; PubMed Central PMCID: PMC1077671.

580: Holley AE, Frater Y, Gibbs AH, De Matteis F, Lamb JH, Farmer PB, Naylor S.
Isolation of two N-monosubstituted protoporphyrins, bearing either the whole drug
or a methyl group on the pyrrole nitrogen atom, from liver of mice given
griseofulvin. Biochem J. 1991 Mar 15;274 ( Pt 3):843-8. PubMed PMID: 2012610;
PubMed Central PMCID: PMC1149987.

581: Abraham NG. Molecular regulation--biological role of heme in hematopoiesis. 
Blood Rev. 1991 Mar;5(1):19-28. Review. PubMed PMID: 2032026.

582: Brenner DA, Frasier F. Cloning of murine ferrochelatase. Proc Natl Acad Sci 
U S A. 1991 Feb 1;88(3):849-53. PubMed PMID: 1704134; PubMed Central PMCID:
PMC50911.

583: Straka JG, Hill HD, Krikava JM, Kools AM, Bloomer JR. Immunochemical studies
of ferrochelatase protein: characterization of the normal and mutant protein in
bovine and human protoporphyria. Am J Hum Genet. 1991 Jan;48(1):72-8. PubMed
PMID: 1985464; PubMed Central PMCID: PMC1682745.

584: Ríos de Molina MC, Billi de Catabbi S, San Martín de Viale LC. Liver
ferrochelatase from normal and hexachlorobenzene porphyric rats. Mechanism of
drug action. Int J Biochem. 1991;23(7-8):669-73. PubMed PMID: 1864443.

585: Navone NM, Buzaleh AM, Polo CF, Afonso SG, Vázquez ES, Batlle AM. The effect
of griseofulvin on the heme pathway--II. An exhaustive analysis during short and 
long-term challenge. Gen Pharmacol. 1991;22(6):1179-83. PubMed PMID: 1810812.

586: Morawiec M. [Effects of harmful trace elements on iron, zinc and copper:
their interactions in animals and humans. II. Lead]. Rocz Panstw Zakl Hig.
1991;42(2):121-6. Polish. PubMed PMID: 1803438.

587: Nakahashi Y, Taketani S, Okuda M, Inoue K, Tokunaga R. Molecular cloning and
sequence analysis of cDNA encoding human ferrochelatase. Biochem Biophys Res
Commun. 1990 Dec 14;173(2):748-55. PubMed PMID: 2260980.

588: Taketani S, Nakahashi Y, Osumi T, Tokunaga R. Molecular cloning, sequencing,
and expression of mouse ferrochelatase. J Biol Chem. 1990 Nov
15;265(32):19377-80. PubMed PMID: 2246229.

589: Li F, Lim CK, Peters TJ. Coproporphyrinogen oxidase, protoporphyrinogen
oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated
rats. Biomed Chromatogr. 1990 Nov;4(6):253-6. PubMed PMID: 2289051.

590: Rossi E, Costin KA, Garcia-Webb P. Effect of occupational lead exposure on
lymphocyte enzymes involved in heme biosynthesis. Clin Chem. 1990
Nov;36(11):1980-3. PubMed PMID: 2242583.

591: Gokhman I, Zamir A. The nucleotide sequence of the ferrochelatase and
tRNA(val) gene region from Saccharomyces cerevisiae. Nucleic Acids Res. 1990 Oct 
25;18(20):6130. PubMed PMID: 2235498; PubMed Central PMCID: PMC332419.

592: Norris PG, Nunn AV, Hawk JL, Cox TM. Genetic heterogeneity in erythropoietic
protoporphyria: a study of the enzymatic defect in nine affected families. J
Invest Dermatol. 1990 Sep;95(3):260-3. PubMed PMID: 2384686.

593: Cochran AG, Schultz PG. Antibody-catalyzed porphyrin metallation. Science.
1990 Aug 17;249(4970):781-3. PubMed PMID: 2389144.

594: Cánepa ET, Llambías EB, Grinstein M. Studies on induction of
delta-aminolevulinic acid synthase, ferrochelatase, cytochrome P-450 and cyclic
AMP by phenformin. Chlorpropamide, allylisopropylacetamide and lead in
hepatocytes from normal and experimental diabetic rats. Biochem Pharmacol. 1990
Jul 15;40(2):365-72. PubMed PMID: 2165405.

595: Blom C, Klasen EC, Van Steveninck J. Different characteristics of
ferrochelatase in cultured fibroblasts of erythropoietic protoporphyria patients 
and normal controls. Biochim Biophys Acta. 1990 Jul 6;1039(3):339-42. PubMed
PMID: 2378891.

596: Mackie JE, Ortiz de Montellano PR, Grab LA, Marks GS. Effects of
3-(2-phenylethyl)-4-methylsydnone and related sydnones on heme biosynthesis.
Biochem Pharmacol. 1990 Jun 1;39(11):1767-74. PubMed PMID: 2344374.

597: Cánepa ET, Llambías EB, Grinstein M. Studies on regulatory mechanisms of
heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role
of insulin. Biochem Cell Biol. 1990 Jun;68(6):914-21. PubMed PMID: 2168718.

598: Rossi E, Attwood PV, Garcia-Webb P, Costin KA. Inhibition of human
lymphocyte ferrochelatase activity by hemin. Biochim Biophys Acta. 1990 May
8;1038(3):375-81. PubMed PMID: 2340297.

599: Labbe-Bois R. The ferrochelatase from Saccharomyces cerevisiae. Sequence,
disruption, and expression of its structural gene HEM15. J Biol Chem. 1990 May
5;265(13):7278-83. PubMed PMID: 2185242.

600: Rossi E, Attwood PV, Garcia-Webb P, Costin KA. Metal inhibition of
ferrochelatase activity in human lymphocytes. Clin Chim Acta. 1990 Apr
13;188(1):1-13. PubMed PMID: 2347080.

601: Jäppinen P, Tenhunen R. Hydrogen sulphide poisoning: blood sulphide
concentration and changes in haem metabolism. Br J Ind Med. 1990 Apr;47(4):283-5.
PubMed PMID: 2337537; PubMed Central PMCID: PMC1035152.

602: Fujishiro K, Mori K, Inoue N. Chronic inhalation effects of ethylene oxide
on porphyrin-heme metabolism. Toxicology. 1990 Mar 30;61(1):1-11. PubMed PMID:
2315947.

603: Nakahashi Y, Taketani S, Sameshima Y, Tokunaga R. Characterization of
ferrochelatase in kidney and erythroleukemia cells. Biochim Biophys Acta. 1990
Mar 1;1037(3):321-7. PubMed PMID: 2310748.

604: Rosenlöf K, Fyhrquist F, Tenhunen R. Erythropoietin, aluminium, and anaemia 
in patients on haemodialysis. Lancet. 1990 Feb 3;335(8684):247-9. PubMed PMID:
1967718.

605: Tovey JA, Elder GH. Ferrochelatase activity in human lymphocytes: effect of 
storage on haem formation. Ann Clin Biochem. 1990 Jan;27 ( Pt 1):80-1. PubMed
PMID: 2310162.

606: Holley A, King LJ, Gibbs AH, De Matteis F. Strain and sex differences in the
response of mice to drugs that induce protoporphyria: role of porphyrin
biosynthesis and removal. J Biochem Toxicol. 1990 Fall;5(3):175-82. PubMed PMID: 
2283668.

607: Tenhunen R. Erythropoietin in the regulation of heme synthesis. Scand J Clin
Lab Invest Suppl. 1990;202:60-2. PubMed PMID: 2075450.

608: Dailey HA, Jones CS, Karr SW. Interaction of free porphyrins and
metalloporphyrins with mouse ferrochelatase. A model for the active site of
ferrochelatase. Biochim Biophys Acta. 1989 Nov 9;999(1):7-11. PubMed PMID:
2804139.

609: Cánepa ET, Llambías EB, Grinstein M. Studies on regulatory mechanisms of
heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role
of cAMP. Biochem Cell Biol. 1989 Nov-Dec;67(11-12):751-8. PubMed PMID: 2559756.

610: McCluskey SA, Whitney RA, Marks GS. Evidence for the stereoselective
inhibition of chick embryo hepatic ferrochelatase by N-alkylated porphyrins. Mol 
Pharmacol. 1989 Oct;36(4):608-14. PubMed PMID: 2811858.

611: Mackie JE, Marks GS. Synergistic induction of delta-aminolevulinic acid
synthase activity by N-ethylprotoporphyrin IX and
3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-isobutylpyridine . Biochem
Pharmacol. 1989 Jul 1;38(13):2169-73. PubMed PMID: 2735955.

612: Marks GS, McCluskey SA, Mackie JE, Riddick DS, James CA. Interaction of
chemicals with cytochrome P-450: implications for the porphyrinogenicity of
drugs. Clin Biochem. 1989 Jun;22(3):169-75. PubMed PMID: 2736770.

613: Kools AM, Straka JG, Hill HD, Whitmer DI, Holman RT, Bloomer JR. Modulation 
of hepatic ferrochelatase activity by dietary manipulation of mitochondrial
phospholipid fatty acyl groups. Hepatology. 1989 Apr;9(4):557-61. PubMed PMID:
2925161.

614: Kondo M, Ohe M, Mizuguchi M. Decreased leukocyte ferrochelatase activity in 
erythropoietic protoporphyria. J Dermatol. 1989 Apr;16(2):116-21. PubMed PMID:
2778187.

615: Piotte M, Hassoun A, Bourlond A, Cornu G. Erythropoietic protoporphyria in a
child. Eur J Pediatr. 1989 Apr;148(6):507-9. PubMed PMID: 2744012.

616: Torra M, Rodamilans M, To-Figueras J, Hornos I, Corbella J. Delta
aminolevulinic acid dehydratase and ferrochelatase activities during chronic lead
exposure in mice. Bull Environ Contam Toxicol. 1989 Apr;42(4):476-81. PubMed
PMID: 2713521.

617: Li F, Lim CK, Simpson KJ, Peters TJ. Coproporphyrinogen oxidase,
protoporphyrinogen oxidase and ferrochelatase activities in human liver biopsies 
with special reference to alcoholic liver disease. J Hepatol. 1989
Jan;8(1):86-93. PubMed PMID: 2921508.

618: Rios de Molina MC, Taira MC, San Martin de Viale LC. Liver ferrochelatase
from normal and hexachlorobenzene porphyric rats. Studies on their properties.
Int J Biochem. 1989;21(2):219-25. PubMed PMID: 2744203.

619: Reed CJ, van den Broeke LT, De Matteis F. Drug-induced protoporphyria in the
olfactory mucosa of the hamster. J Biochem Toxicol. 1989 Fall;4(3):161-4. PubMed 
PMID: 2607541.

620: Beru N, Goldwasser E. Studies of the effect of erythropoietin on heme
synthesis. Adv Exp Med Biol. 1989;271:87-94. PubMed PMID: 2486291.

621: Marks GS, Mackie JE, McCluskey SA, Riddick DS. Regulation of heme
biosynthesis in chick embryo liver cells. Adv Exp Med Biol. 1989;271:123-33.
Review. PubMed PMID: 2486279.

622: Price MJ, Saiz BL, Barton LL. Ferrochelatase activity in Azospirillum
brasilense with reference to the influence of metal cations. Biol Met.
1989;2(1):31-5. PubMed PMID: 2485650.

623: Schoenfeld N, Epstein O, Lahav M, Mamet R, Shaklai M, Atsmon A. The heme
biosynthetic pathway in lymphocytes of patients with malignant
lymphoproliferative disorders. Cancer Lett. 1988 Dec 1;43(1-2):43-8. PubMed PMID:
3203329.

624: Rossi E, Costin KA, Garcia-Webb P. Ferrochelatase activity in human
lymphocytes, as quantified by a new high-performance liquid-chromatographic
method. Clin Chem. 1988 Dec;34(12):2481-5. PubMed PMID: 3197287.

625: Nunn AV, Norris P, Hawk JL, Cox TM. Zinc chelatase in human lymphocytes:
detection of the enzymatic defect in erythropoietic protoporphyria. Anal Biochem.
1988 Oct;174(1):146-50. PubMed PMID: 3218729.

626: Woods JS. Regulation of porphyrin and heme metabolism in the kidney. Semin
Hematol. 1988 Oct;25(4):336-48. Review. PubMed PMID: 3064315.

627: De Matteis F. Toxicological aspects of liver heme biosynthesis. Semin
Hematol. 1988 Oct;25(4):321-9. Review. PubMed PMID: 3064313.

628: Karr SR, Dailey HA. The synthesis of murine ferrochelatase in vitro and in
vivo. Biochem J. 1988 Sep 15;254(3):799-803. PubMed PMID: 3196293; PubMed Central
PMCID: PMC1135153.

629: Polson RJ, Lim CK, Rolles K, Calne RY, Williams R. The effect of liver
transplantation in a 13-year-old boy with erythropoietic protoporphyria.
Transplantation. 1988 Sep;46(3):386-9. PubMed PMID: 3047929.

630: Marks GS, McCluskey SA, Mackie JE, Riddick DS, James CA. Disruption of
hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450.
FASEB J. 1988 Sep;2(12):2774-83. Review. PubMed PMID: 3044903.

631: Camadro JM, Labbe P. Purification and properties of ferrochelatase from the 
yeast Saccharomyces cerevisiae. Evidence for a precursor form of the protein. J
Biol Chem. 1988 Aug 25;263(24):11675-82. PubMed PMID: 3042776.

632: McCluskey SA, Marks GS, Whitney RA, Ortiz de Montellano PR. Differential
inhibition of hepatic ferrochelatase by regioisomers of N-butyl-, N-pentyl-,
N-hexyl-, and N-isobutylprotoporphyrin IX. Mol Pharmacol. 1988 Jul;34(1):80-6.
PubMed PMID: 3393143.

633: Lukton D, Mackie JE, Lee JS, Marks GS, Ortiz de Montellano PR.
2,2-Dialkyl-1,2-dihydroquinolines: cytochrome P-450 catalyzed N-alkylporphyrin
formation, ferrochelatase inhibition, and induction of 5-aminolevulinic acid
synthase activity. Chem Res Toxicol. 1988 Jul-Aug;1(4):208-15. PubMed PMID:
2979733.

634: Ferreira GC, Andrew TL, Karr SW, Dailey HA. Organization of the terminal two
enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen
oxidase and evidence for a membrane complex. J Biol Chem. 1988 Mar
15;263(8):3835-9. PubMed PMID: 3346226.

635: Siddiqui SM, Rao GS, Pandya KP. Depletion of liver regulatory heme in
benzene exposed rats. Toxicology. 1988 Mar;48(3):245-51. PubMed PMID: 3344524.

636: Ferreira GC, Dailey HA. Mouse protoporphyrinogen oxidase. Kinetic parameters
and demonstration of inhibition by bilirubin. Biochem J. 1988 Mar
1;250(2):597-603. PubMed PMID: 2451512; PubMed Central PMCID: PMC1148896.

637: Klingberg J, Beviz A, Ohlson CG, Tenhunen R. Disturbed iron metabolism among
workers exposed to organic sulfides in a pulp plant. Scand J Work Environ Health.
1988 Feb;14(1):17-20. PubMed PMID: 3353691.

638: Cánepa ET, Llambías EB. Purification and characterization of ferro- and
cobalto-chelatases. Biochem Cell Biol. 1988 Jan;66(1):32-9. PubMed PMID: 3370141.

639: Brown AC, Lutton JD, Pearson HA, Nelson JC, Levere RD, Abraham NG. Heme
metabolism and in vitro erythropoiesis in anemia associated with hypochromic
microcytosis. Am J Hematol. 1988 Jan;27(1):1-6. PubMed PMID: 3354554.

640: Posnett SJ, Oosthuizen MM, Cantrell AC, Myburgh JA. Properties of membrane
bound ferrochelatase purified from baboon liver mitochondria. Int J Biochem.
1988;20(8):845-55. PubMed PMID: 3169367.

641: de Sélys R, Decroix J, Frankart M, Hassoun A, Willocx D, Pirard C, Bourlond 
A. [Erythropoietic protoporphyria]. Ann Dermatol Venereol. 1988;115(5):555-60.
French. PubMed PMID: 3143300.

642: Heinicke HJ, Köstler E, Töppich D, Paul R. [Protoporphyrinemia and iron
metabolism in hemodialysis patients]. Z Gesamte Inn Med. 1987 Dec 1;42(23):683-5.
German. PubMed PMID: 3445653.

643: Schoenfeld N, Mamet R, Epstein O, Lahav M, Lurie Y, Atsmon A. The heme
biosynthetic pathway in the regenerating rat liver. The relation between enzymes 
of heme synthesis and growth. Eur J Biochem. 1987 Aug 3;166(3):663-6. PubMed
PMID: 2886336.

644: Tenhunen R, Savolainen H. Effect of exogenous heme on sulfide-induced
changes in rat heme metabolism. Res Commun Chem Pathol Pharmacol. 1987
Aug;57(2):285-8. PubMed PMID: 3659574.

645: Siepker LJ, Ford M, de Kock R, Kramer S. Purification of bovine
protoporphyrinogen oxidase: immunological cross-reactivity and structural
relationship to ferrochelatase. Biochim Biophys Acta. 1987 Jul 7;913(3):349-58.
PubMed PMID: 2439126.

646: McCluskey SA, Sutherland EP, Racz WJ, Marks GS. Isolation of an
N-alkylprotoporphyrin IX from chick embryo livers following the administration of
3,5-diethoxycarbonyl-1,4-dihydro-4-ethyl-2,6-dimethylpyridine. Can J Physiol
Pharmacol. 1987 Jul;65(7):1500-2. PubMed PMID: 3664364.

647: Marks GS. The 1986 Upjohn award lecture. Interaction of chemicals with
hemoproteins: implications for the mechanism of action of porphyrinogenic drugs
and nitroglycerin. Can J Physiol Pharmacol. 1987 Jun;65(6):1111-9. Review. PubMed
PMID: 3113708.

648: Gondal JA, Eiseman JL, Alvares AP. Regulation of heme metabolism and
monooxygeneses in liver and kidney: influence of therapeutically used gold
compounds. J Pharmacol Exp Ther. 1987 May;241(2):540-6. PubMed PMID: 3106619.

649: Fadigan A, Dailey HA. Inhibition of ferrochelatase during differentiation of
murine erythroleukaemia cells. Biochem J. 1987 Apr 15;243(2):419-24. PubMed PMID:
3477226; PubMed Central PMCID: PMC1147871.

650: Mathews-Roth MM, Drouin GL, Duffy L. Isolation of human ferrochelatase. Arch
Dermatol. 1987 Apr;123(4):429-30. PubMed PMID: 3827270.

651: Ferreira GC, Dailey HA. Reconstitution of the two terminal enzymes of the
heme biosynthetic pathway into phospholipid vesicles. J Biol Chem. 1987 Mar
25;262(9):4407-12. PubMed PMID: 3558411.

652: Deybach JC, Da Silva V, Phung LN, Levy JC, Nordmann Y. [Drug risk of hepatic
porphyria. Development of an animal experiment model]. Presse Med. 1987 Jan
24;16(2):68-71. French. PubMed PMID: 2949310.

653: Bloomer JR, Hill HD, Morton KO, Anderson-Burnham LA, Straka JG. The enzyme
defect in bovine protoporphyria. Studies with purified ferrochelatase. J Biol
Chem. 1987 Jan 15;262(2):667-71. PubMed PMID: 3805002.

654: Li FM, Lim CK, Peters TJ. An HPLC assay for rat liver ferrochelatase
activity. Biomed Chromatogr. 1987;2(4):164-8. PubMed PMID: 3507230.

655: Roberts RG. HPLC determination of ferrochelatase activity in human liver.
Biomed Chromatogr. 1987;2(2):71-5. PubMed PMID: 3506837.

656: Dailey HA. Metal inhibition of ferrochelatase. Ann N Y Acad Sci.
1987;514:81-6. PubMed PMID: 3442391.

657: Labbé RF, Rettmer RL, Shah AG, Turnlund JR. Zinc protoporphyrin. Past,
present, and future. Ann N Y Acad Sci. 1987;514:7-14. Review. PubMed PMID:
3327439.

658: Smith A. Mechanisms of toxicity of photoactivated artificial porphyrins.
Role of porphyrin-protein interactions. Ann N Y Acad Sci. 1987;514:309-22.
Review. PubMed PMID: 3327434.

659: De Matteis F, Gibbs AH, Holley AE. Occurrence and biological properties of
N-methyl protoporphyrin. Ann N Y Acad Sci. 1987;514:30-40. Review. PubMed PMID:
3327433.

660: Piomelli S, Seaman C, Kapoor S. Lead-induced abnormalities of porphyrin
metabolism. The relationship with iron deficiency. Ann N Y Acad Sci.
1987;514:278-88. Review. PubMed PMID: 3327432.

661: Oskarsson A, Fowler BA. Alterations in renal heme biosynthesis during metal 
nephrotoxicity. Ann N Y Acad Sci. 1987;514:268-77. Review. PubMed PMID: 3327431.

662: Marks GS, Powles J, Lyon M, McCluskey S, Sutherland E, Zelt D. Patterns of
porphyrin accumulation in response to xenobiotics. Parallels between results in
chick embryo and rodents. Ann N Y Acad Sci. 1987;514:113-27. PubMed PMID:
3126696.

663: McCluskey SA, Marks GS, Sutherland EP, Jacobsen N, Ortiz de Montellano PR.
Ferrochelatase-inhibitory activity and N-alkylprotoporphyrin formation with
analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC)
containing extended 4-alkyl groups: implications for the active site of
ferrochelatase. Mol Pharmacol. 1986 Oct;30(4):352-7. PubMed PMID: 3762522.

664: Taketani S, Tanaka-Yoshioka A, Masaki R, Tashiro Y, Tokunaga R. Association 
of ferrochelatase with Complex I in bovine heart mitochondria. Biochim Biophys
Acta. 1986 Sep 4;883(2):277-83. PubMed PMID: 3091080.

665: Williams H, Johnson D, Slater S. The effects of various substituted
hydrocarbons on two heme synthesis regulatory enzymes. Res Commun Chem Pathol
Pharmacol. 1986 Sep;53(3):373-80. PubMed PMID: 3775105.

666: Bhaya D, Castelfranco PA. Synthesis of a Putative c-Type Cytochrome by
Intact, Isolated Pea Chloroplast. Plant Physiol. 1986 Aug;81(4):960-964. PubMed
PMID: 16664965; PubMed Central PMCID: PMC1075467.

667: Veltman JC, Maines MD. Alterations of heme, cytochrome P-450, and steroid
metabolism by mercury in rat adrenal. Arch Biochem Biophys. 1986 Aug
1;248(2):467-78. PubMed PMID: 2943220.

668: Maines MD. Differential effect of cis-platinum
(cis-diamminedichloroplatinum) on regulation of liver and kidney haem and
haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes.
Biochem J. 1986 Aug 1;237(3):713-21. PubMed PMID: 2879531; PubMed Central PMCID: 
PMC1147049.

669: Shanker J, Datta K. Excess generation of endogenous heme inhibits
L-alanine:4,5-dioxovalerate transaminase in rat liver mitochondria. Biochem
Biophys Res Commun. 1986 Jul 31;138(2):751-7. PubMed PMID: 3741431.

670: Rogan WJ, Reigart JR, Gladen BC. Association of amino levulinate dehydratase
levels and ferrochelatase inhibition in childhood lead exposure. J Pediatr. 1986 
Jul;109(1):60-4. PubMed PMID: 3723241.

671: Gordeuk VR, Brittenham GM, Hawkins CW, Mukhtar H, Bickers DR. Iron therapy
for hepatic dysfunction in erythropoietic protoporphyria. Ann Intern Med. 1986
Jul;105(1):27-31. PubMed PMID: 3717807.

672: Dailey HA, Fleming JE. The role of arginyl residues in porphyrin binding to 
ferrochelatase. J Biol Chem. 1986 Jun 15;261(17):7902-5. PubMed PMID: 3711115.

673: Tangerås A. Effect of decreased ferrochelatase activity on iron and
porphyrin content in mitochondria of mice with porphyria induced by griseofulvin.
Biochim Biophys Acta. 1986 Jun 3;882(1):77-84. PubMed PMID: 3707999.

674: Bannerman RM, Garrick LM, Rusnak-Smalley P, Hoke JE, Edwards JA. Hemoglobin 
deficit: an inherited hypochromic anemia in the mouse. Proc Soc Exp Biol Med.
1986 May;182(1):52-7. PubMed PMID: 3960859.

675: Woods JS, Fowler BA. Alteration of hepatocellular structure and function by 
thallium chloride: ultrastructural, morphometric, and biochemical studies.
Toxicol Appl Pharmacol. 1986 Apr;83(2):218-29. PubMed PMID: 3961812.

676: Marks GS, Allen DT, Sutherland EP, McCluskey SA, Whitney RA. Comparison of
the effects of 3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine and
3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase
activity and heme biosynthesis in chick embryo liver cells in culture. Can J
Physiol Pharmacol. 1986 Apr;64(4):483-6. PubMed PMID: 3730932.

677: Marks GS, Goldman DR, McCluskey SA, Sutherland EP, Lyon ME. The effects of
dihydropyridine calcium antagonists on heme biosynthesis in chick embryo liver
cell culture. Can J Physiol Pharmacol. 1986 Apr;64(4):438-43. PubMed PMID:
3730927.

678: Abraham NG, Camadro JM, Hoffstein ST, Levere RD. Effects of iron deficiency 
and chronic iron overloading on mitochondrial heme biosynthetic enzymes in rat
liver. Biochim Biophys Acta. 1986 Mar 28;870(2):339-49. PubMed PMID: 3955059.

679: Sutherland EP, Marks GS, Grab LA, Ortiz de Montellano PR. Porphyrinogenic
activity and ferrochelatase-inhibitory activity of sydnones in chick embryo liver
cells. FEBS Lett. 1986 Mar 3;197(1-2):17-20. PubMed PMID: 3949013.

680: Dailey HA. Purification and characterization of bacterial ferrochelatase.
Methods Enzymol. 1986;123:408-15. PubMed PMID: 3702737.

681: Dailey HA, Fleming JE, Harbin BM. Purification and characterization of
mammalian and chicken ferrochelatase. Methods Enzymol. 1986;123:401-8. PubMed
PMID: 3702736.

682: Salzman TA, Batlle AM. Heme synthetase in Trypanosoma cruzi. Comp Biochem
Physiol B. 1986;85(3):537-41. PubMed PMID: 3539502.

683: Salzman TA, Batlle AM, de Souza W. Heme synthesis in Trypanosoma cruzi:
influence of the strain and culture medium. Comp Biochem Physiol B.
1986;83(1):57-61. PubMed PMID: 3510810.

684: Dailey HA, Fleming JE, Harbin BM. Ferrochelatase from Rhodopseudomonas
sphaeroides: substrate specificity and role of sulfhydryl and arginyl residues. J
Bacteriol. 1986 Jan;165(1):1-5. PubMed PMID: 3484475; PubMed Central PMCID:
PMC214361.

685: Tangerås A. Mitochondrial iron not bound in heme and iron-sulfur centers and
its availability for heme synthesis in vitro. Biochim Biophys Acta. 1985 Dec
13;843(3):199-207. PubMed PMID: 4063392.

686: Oskarsson A, Fowler BA. Effects of lead on the heme biosynthetic pathway in 
rat kidney. Exp Mol Pathol. 1985 Dec;43(3):409-17. PubMed PMID: 4065316.

687: Leeper FJ. The biosynthesis of porphyrins, chlorophylls, and vitamin B12.
Nat Prod Rep. 1985 Dec;2(6):561-80. Review. PubMed PMID: 3913886.

688: Cánepa ET, Galvagno MA, Llambías EB, Passeron S, Grinstein M. Studies on
regulatory mechanisms of heme biosynthesis in hepatocytes from
experimental-diabetic rats. Biochim Biophys Acta. 1985 Nov 20;847(2):191-7.
PubMed PMID: 2998479.

689: Savolainen H, Jäppinen P, Tenhunen R. Reversal of sulfide-induced effects on
porphyrin metabolism by exogenous heme. Res Commun Chem Pathol Pharmacol. 1985
Nov;50(2):245-50. PubMed PMID: 4081316.

690: Johnson DJ, Williams HL, Slater S, Haut MJ, Altstatt LB. The in vitro
effects of selected environmental toxicants on two heme synthesis enzymes. J
Environ Pathol Toxicol Oncol. 1985 Nov-Dec;6(2):211-8. PubMed PMID: 4078689.

691: Kurlandzka A, Rytka J. Mutants of Saccharomyces cerevisiae partially
defective in the last steps of the haem biosynthetic pathway: isolation and
genetical characterization. J Gen Microbiol. 1985 Nov;131(11):2909-18. PubMed
PMID: 3912462.

692: Taketani S, Tanaka A, Tokunaga R. Reconstitution of heme-synthesizing
activity from ferric ion and porphyrins, and the effect of lead on the activity. 
Arch Biochem Biophys. 1985 Oct;242(1):291-6. PubMed PMID: 3931555.

693: Cánepa ET, Llambías EB, Grinstein M. Effect of glucose on induction of
delta-aminolevulinic acid synthase, ferrochelatase and cytochrome P-450
hemoproteins in isolated rat hepatocytes by phenobarbital and lead. Biochim
Biophys Acta. 1985 Aug 16;841(2):186-94. PubMed PMID: 2990571.

694: Labbe P, Camadro JM, Chambon H. Fluorometric assays for coproporphyrinogen
oxidase and protoporphyrinogen oxidase. Anal Biochem. 1985 Aug 15;149(1):248-60. 
PubMed PMID: 3907404.

695: Beru N, Goldwasser E. The regulation of heme biosynthesis during
erythropoietin-induced erythroid differentiation. J Biol Chem. 1985 Aug
5;260(16):9251-7. PubMed PMID: 4019471.

696: Jollie DR, Maines MD. Effect of cis-platinum on kidney cytochrome P-450 and 
heme metabolism: evidence for the regulatory role of the pituitary hormones. Arch
Biochem Biophys. 1985 Jul;240(1):51-9. PubMed PMID: 4040350.

697: Maines MD, Mayer RD. Inhibition of testicular cytochrome P-450-dependent
steroid biosynthesis by cis-platinum. Reversal by human chorionic gonadotropin. J
Biol Chem. 1985 May 25;260(10):6063-8. PubMed PMID: 4039724.

698: Varypaeva LP, Zakharov IuM. [Interrelation of the morphofunctional
characteristics of the erythron and heme-synthesizing enzyme activity during heat
exposure]. Fiziol Zh SSSR Im I M Sechenova. 1985 May;71(5):625-30. Russian.
PubMed PMID: 4018296.

699: Savolainen H, Tenhunen R, Härkönen H. Reticulocyte haem synthesis in
occupational exposure to trinitrotoluene. Br J Ind Med. 1985 May;42(5):354-5.
PubMed PMID: 3986148; PubMed Central PMCID: PMC1007485.

700: Siepker LJ, Kramer S. Protoporphyrin accumulation by mitogen stimulated
lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria
variegata and erythropoietic protoporphyria: evidence for deficiency of
protoporphyrinogen oxidase and ferrochelatase in both diseases. Br J Haematol.
1985 May;60(1):65-74. PubMed PMID: 3924091.

701: Marks GS, Allen DT, Johnston CT, Sutherland EP, Nakatsu K, Whitney RA.
Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity
by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in 
chick embryo liver cells. Mol Pharmacol. 1985 Apr;27(4):459-65. PubMed PMID:
3982391.

702: Ponka P, Schulman HM. Regulation of heme synthesis in erythroid cells: hemin
inhibits transferrin iron utilization but not protoporphyrin synthesis. Blood.
1985 Apr;65(4):850-7. PubMed PMID: 3978231.

703: Lumeij JT. Clinicopathologic aspects of lead poisoning in birds: a review.
Vet Q. 1985 Apr;7(2):133-8. Review. PubMed PMID: 3892878.

704: Buchberg AM, Kinniburgh AJ. Induction of liver apolipoprotein A-IV mRNA in
porphyric mice. Nucleic Acids Res. 1985 Mar 25;13(6):1953-63. PubMed PMID:
4000948; PubMed Central PMCID: PMC341127.

705: Dailey HA. Spectroscopic examination of the active site of bovine
ferrochelatase. Biochemistry. 1985 Mar 12;24(6):1287-91. PubMed PMID: 3986176.

706: Moody MD, Dailey HA. Iron transport and its relation to heme biosynthesis in
Rhodopseudomonas sphaeroides. J Bacteriol. 1985 Mar;161(3):1074-9. PubMed PMID:
3871762; PubMed Central PMCID: PMC215009.

707: De Matteis F, Gibbs AH, Harvey C. Studies on the inhibition of
ferrochelatase by N-alkylated dicarboxylic porphyrins. Steric factors involved
and evidence that the inhibition is reversible. Biochem J. 1985 Mar
1;226(2):537-44. PubMed PMID: 3838893; PubMed Central PMCID: PMC1144741.

708: Stavem P, Romslo I, Hovig T, Rootwelt K, Emblem R. Ferrochelatase deficiency
of the bone marrow in a syndrome of congenital microcytic anaemia with iron
overload of the liver and hyperferraemia. Scand J Haematol. 1985 Feb;34(2):204-6.
PubMed PMID: 3975573.

709: Leeper FJ. The biosynthesis of porphyrins, chlorophylls, and vitamin B12.
Nat Prod Rep. 1985 Feb;2(1):19-47. Review. PubMed PMID: 3895052.

710: Harbin BM, Dailey HA. Orientation of ferrochelatase in bovine liver
mitochondria. Biochemistry. 1985 Jan 15;24(2):366-70. PubMed PMID: 3884041.

711: Stavem P, Romslo I, Hovig T, Rootwelt K, Emblem R. Ferrochelatase deficiency
in the bone marrow in a syndrome of congenital hypochromic microcytic anemia,
hyperferremia, and iron overload of the liver. Scand J Gastroenterol Suppl.
1985;107:73-81. PubMed PMID: 3856939.

712: Lim CK, Rideout JM, Peters TJ. High-performance liquid chromatography of
dicarboxylic porphyrins and metalloporphyrins: retention behaviour and biomedical
applications. J Chromatogr. 1984 Dec 28;317:333-41. PubMed PMID: 6530440.

713: Dailey HA, Smith A. Differential interaction of porphyrins used in
photoradiation therapy with ferrochelatase. Biochem J. 1984 Oct 15;223(2):441-5. 
PubMed PMID: 6497856; PubMed Central PMCID: PMC1144316.

714: Beaumont C, Deybach JC, Grandchamp B, da Silva V, de Verneuil H, Nordmann Y.
Effects of succinylacetone on dimethylsulfoxide-mediated induction of heme
pathway enzymes in mouse friend virus-transformed erythroleukemia cells. Exp Cell
Res. 1984 Oct;154(2):474-84. PubMed PMID: 6592100.

715: Moody DE, Clawson GA, Piper WN, Smuckler EA. Effects of
1,2-dibromo-3-chloropropane on hepatic heme synthesis. Toxicol Appl Pharmacol.
1984 Sep 30;75(3):561-70. PubMed PMID: 6548049.

716: Hanson JW, Dailey HA. Purification and characterization of chicken
erythrocyte ferrochelatase. Biochem J. 1984 Sep 15;222(3):695-700. PubMed PMID:
6487270; PubMed Central PMCID: PMC1144232.

717: Tangerås A. Separation of haem compounds by reversed-phase ion-pair
high-performance liquid chromatography and its application in the assay of
ferrochelatase activity. J Chromatogr. 1984 Sep 14;310(1):31-9. PubMed PMID:
6501520.

718: Cole SP, Marks GS. Ferrochelatase and N-alkylated porphyrins. Mol Cell
Biochem. 1984 Sep;64(2):127-37. Review. PubMed PMID: 6390167.

719: Maines MD, Jollie DR. Dissociation of heme metabolic activities from the
microsomal cytochrome P-450 turnover in testis of hypophysectomized rats. J Biol 
Chem. 1984 Aug 10;259(15):9557-62. PubMed PMID: 6746660.

720: Brown SB, Holroyd JA, Vernon DI, Jones OT. Ferrochelatase activity in the
photosynthetic alga Cyanidium caldarium. Development of the enzyme during
biosynthesis of photosynthetic pigments. Biochem J. 1984 Jun 15;220(3):861-3.
PubMed PMID: 6466309; PubMed Central PMCID: PMC1153708.

721: Tenhunen R, Zitting A, Nickels J, Savolainen H. Trinitrotoluene-induced
effects on rat heme metabolism. Exp Mol Pathol. 1984 Jun;40(3):362-6. PubMed
PMID: 6547098.

722: Cánepa ET, Llambías EB, Grinstein M. Effect of glucose on the induction of
delta-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes
by allylisopropylacetamide. Biochim Biophys Acta. 1984 May 22;804(1):8-15. PubMed
PMID: 6326846.

723: Camadro JM, Ibraham NG, Levere RD. Kinetic studies of human liver
ferrochelatase. Role of endogenous metals. J Biol Chem. 1984 May
10;259(9):5678-82. PubMed PMID: 6425295.

724: Walden TL, Draganac PS, Farkas WR. The elevation of blood levels of zinc
protoporphyrin in mice following whole body irradiation. Blood. 1984
May;63(5):1159-67. PubMed PMID: 6324927.

725: Wainstok de Calmanovici R, Ríos de Molina MC, Taira de Yamasato MC, Tomio
JM, San Martin de Viale LC. Mechanism of hexachlorobenzene-induced porphyria in
rats. Effect of phenobarbitone pretreatment. Biochem J. 1984 Mar
15;218(3):753-63. PubMed PMID: 6721832; PubMed Central PMCID: PMC1153403.

726: Dailey HA. Effect of sulfhydryl group modification on the activity of bovine
ferrochelatase. J Biol Chem. 1984 Mar 10;259(5):2711-5. PubMed PMID: 6698990.

727: Amuro N, Okada S, Goto Y, Shukuya R. Synthesis of cytochrome c oxidase in
the liver of Rana catesbeiana tadpole treated with griseofulvin. Biochim Biophys 
Acta. 1984 Feb 24;781(1-2):14-7. PubMed PMID: 6320891.

728: Prasad AR, Datta K. Altered regulation of hepatic heme metabolism in cadmium
exposed chick embryo. Biochem Int. 1984 Feb;8(2):289-98. PubMed PMID: 6548141.

729: Maines MD. New developments in the regulation of heme metabolism and their
implications. Crit Rev Toxicol. 1984;12(3):241-314. Review. PubMed PMID: 6378529.

730: Yamada M, Kondo M, Tanaka M, Okeda R, Hatakeyama S, Fukui T, Tsukagoshi H.
An autopsy case of acute porphyria with a decrease of both uroporphyrinogen I
synthetase and ferrochelatase activities. Acta Neuropathol. 1984;64(1):6-11.
PubMed PMID: 6089495.

731: Henderson MJ, Toothill C. Urinary coproporphyrin in lead intoxication: a
study in the rabbit. Clin Sci (Lond). 1983 Nov;65(5):527-32. PubMed PMID:
6617099.

732: Pascoe GA, Sakai-Wong J, Soliven E, Correia MA. Regulation of intestinal
cytochrome P-450 and heme by dietary nutrients. Critical role of selenium.
Biochem Pharmacol. 1983 Oct 15;32(20):3027-35. PubMed PMID: 6639671.

733: Dailey HA, Fleming JE. Bovine ferrochelatase. Kinetic analysis of inhibition
by N-methylprotoporphyrin, manganese, and heme. J Biol Chem. 1983 Oct
10;258(19):11453-9. PubMed PMID: 6688622.

734: Maines MD, Kutty RK. Differential response of testicular and ovarian heme
oxygenase activity to metal ions. Arch Biochem Biophys. 1983 Oct 1;226(1):134-44.
PubMed PMID: 6688941.

735: Nichol AW, Elsbury S, Angel LA, Elder GH. The site of inhibition of
porphyrin biosynthesis by an isomer of diazinon in rats. Biochem Pharmacol. 1983 
Sep 15;32(18):2653-7. PubMed PMID: 6626236.

736: Bloomer JR, Reuter RJ, Morton KO, Wehner JM. Enzymatic formation of
zinc-protoporphyrin by rat liver and its potential effect on hepatic heme
metabolism. Gastroenterology. 1983 Sep;85(3):663-8. PubMed PMID: 6873612.

737: Miranda CL, Wang JL, Henderson MC, Carpenter HM, Nakaue HS, Buhler DR.
Studies on the porphyrinogenic action of 1,2,4-trichlorobenzene in birds.
Toxicology. 1983 Sep;28(1-2):83-92. PubMed PMID: 6636202.

738: De Matteis F, Marks GS. The effect of N-methylprotoporphyrin and
succinyl-acetone on the regulation of heme biosynthesis in chicken hepatocytes in
culture. FEBS Lett. 1983 Aug 8;159(1-2):127-31. PubMed PMID: 6688226.

739: Viljoen DJ, Cummins R, Alexopoulos J, Kramer S. Protoporphyrinogen oxidase
and ferrochelatase in porphyria variegata. Eur J Clin Invest. 1983
Aug;13(4):283-7. PubMed PMID: 6413214.

740: Marks GS, Follows SB, Zelt DT, Cole SP. Patterns of porphyrin accumulation
in response to chemicals in chick embryo liver cells. Can J Physiol Pharmacol.
1983 Jun;61(6):546-53. PubMed PMID: 6883207.

741: Harada K, Miura H. [Heme synthesis and iron turnover in rabbits with
experimental lead poisoning]. Sangyo Igaku. 1983 May;25(3):161-74. Japanese.
PubMed PMID: 6655984.

742: Gaertner RR, Hollebone BR. The in vitro inhibition of hepatic ferrochelatase
by divalent lead and other soft metal ions. Can J Biochem Cell Biol. 1983
Apr;61(4):214-22. PubMed PMID: 6850416.

743: Tenhunen R, Savolainen H, Jäppinen P. Changes in haem synthesis associated
with occupational exposure to organic and inorganic sulphides. Clin Sci (Lond).
1983 Feb;64(2):187-91. PubMed PMID: 6822055.

744: Moreb J, Popovtzer MM, Friedlaender MM, Konijn AM, Hershko C. Evaluation of 
iron status in patients on chronic hemodialysis: relative usefulness of bone
marrow hemosiderin, serum ferritin, transferrin saturation, mean corpuscular
volume and red cell protoporphyrin. Nephron. 1983;35(3):196-200. PubMed PMID:
6633760.

745: Ibraham NG, Friedland ML, Levere RD. Heme metabolism in erythroid and
hepatic cells. Prog Hematol. 1983;13:75-130. Review. PubMed PMID: 6366915.

746: Dailey HA. Purification and characterization of membrane-bound
ferrochelatase from Rhodopseudomonas sphaeroides. J Biol Chem. 1982 Dec
25;257(24):14714-8. PubMed PMID: 6983526.

747: Houghton JD, Honeybourne CL, Smith KM, Tabba HD, Jones OT. The use of
N-methylprotoporphyrin dimethyl ester to inhibit ferrochelatase in
Rhodopseudomonas sphaeroides and its effect in promoting biosynthesis of
magnesium tetrapyrroles. Biochem J. 1982 Nov 15;208(2):479-86. PubMed PMID:
6984332; PubMed Central PMCID: PMC1153987.

748: Camadro JM, Labbe P. Kinetic studies of ferrochelatase in yeast. Zinc or
iron as competing substrates. Biochim Biophys Acta. 1982 Oct 5;707(2):280-8.
PubMed PMID: 6753940.

749: Taketani S, Tokunaga R. Purification and substrate specificity of bovine
liver-ferrochelatase. Eur J Biochem. 1982 Oct;127(3):443-7. PubMed PMID: 7173190.

750: Coffman BL, Ingall G, Tephly TR. The formation of N-alkylprotoporphyrin IX
and destruction of cytochrome P-450 in the liver of rats after treatment with
3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog. Arch Biochem
Biophys. 1982 Oct 1;218(1):220-4. PubMed PMID: 7149729.

751: de Matteis F, Hollands C, Gibbs AH, de Sa N, Rizzardini M. Inactivation of
cytochrome P-450 and production of N-alkylated porphyrins caused in isolated
hepatocytes by substituted dihydropyridines. Structural requirements for loss of 
haem and alkylation of the pyrrole nitrogen atom. FEBS Lett. 1982 Aug
16;145(1):87-92. PubMed PMID: 6897045.

752: Keyhani E, Keyhani J. Biochemical characterization of the OXI mutants of the
yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 1982 Aug 6;717(2):355-68.
PubMed PMID: 6288115.

753: Savolainen H, Tenhunen R. Inhibition of heme synthase in brain and liver by 
low-level peroral sulfite exposure. Res Commun Chem Pathol Pharmacol. 1982
Jun;36(3):511-4. PubMed PMID: 7122992.

754: Bottomley SS. Sideroblastic anaemia. Clin Haematol. 1982 Jun;11(2):389-409. 
Review. PubMed PMID: 7042158.

755: De Matteis F, Jackson AH, Gibbs AH, Rao KR, Atton J, Weerasinghe S, Hollands
C. Structural isomerism and chirality of N-monosubstituted protoporphyrins. FEBS 
Lett. 1982 Jun 1;142(1):44-8. PubMed PMID: 6896691.

756: Elder GH. Enzymatic defects in porphyria: an overview. Semin Liver Dis. 1982
May;2(2):87-99. Review. PubMed PMID: 6753167.

757: Bloomer JR. Protoporphyria. Semin Liver Dis. 1982 May;2(2):143-53. Review.
PubMed PMID: 6753164.

758: Sassa S, Zalar GL, Poh-Fitzpatrick MB, Anderson KE, Kappas A. Studies in
porphyria: functional evidence for a partial deficiency of ferrochelatase
activity in mitogen-stimulated lymphocytes from patients with erythropoietic
protoporphyria. J Clin Invest. 1982 Apr;69(4):809-15. PubMed PMID: 6804493;
PubMed Central PMCID: PMC370135.

759: Sinclair PR, Sinclair JF, Bonkowsky HL, Gibbs AH, De Matteis F. Formation of
cobalt protoporphyrin by chicken hepatocytes in culture. Relationship to decrease
of 5-aminolaevulinate synthase caused by cobalt. Biochem Pharmacol. 1982 Mar
15;31(6):993-9. PubMed PMID: 7082380.

760: Eiseman JL, von Bredow J, Alvares AP. Effect of honeybee (Apis mellifera)
venom on the course of adjuvant-induced arthritis and depression of drug
metabolism in the rat. Biochem Pharmacol. 1982 Mar 15;31(6):1139-46. PubMed PMID:
6177321.

761: Bloomer JR, Morton KO, Reuter RJ, Ruth GR. Bovine protoporphyria:
documentation of autosomal recessive inheritance and comparison with the human
disease through measurement of heme synthase activity. Am J Hum Genet. 1982
Mar;34(2):322-30. PubMed PMID: 7072720; PubMed Central PMCID: PMC1685290.

762: Romslo I, Brun A, Sandberg S, Bottomley SS, Høvding G, Talstad I.
Sideroblastic anemia with markedly increased free erythrocyte protoporphyrin
without dermal photosensitivity. Blood. 1982 Mar;59(3):628-33. PubMed PMID:
7059671.

763: Cole SP, Marks GS, Oritz de Montellano PR, Kunze KL. Inhibition of
ferrochelatase by N-methylprotoporphyrin IX is not accompanied by
delta-aminolevulinic acid synthetase induction in chick embryo liver cell
culture. Can J Physiol Pharmacol. 1982 Feb;60(2):212-5. PubMed PMID: 6896292.

764: Bloomer JR, Morton KO. A radiochemical assay for heme synthase activity.
Enzyme. 1982;28(2-3):220-32. PubMed PMID: 7140723.

765: Kushner JP. The enzymatic defects in porphyria cutanea tarda and variegate
porphyria. Acta Derm Venereol Suppl (Stockh). 1982;100:51-6. PubMed PMID:
6962633.

766: Salzman TA, Stella AM, Wider de Xifra EA, Batlle AM, Docampo R, Stoppani AO.
Porphyrin biosynthesis in parasitic hemoflagellates: functional and defective
enzymes in Trypanosoma cruzi. Comp Biochem Physiol B. 1982;72(4):663-7. PubMed
PMID: 6751683.

767: Taketani S, Tokunaga R. Rat liver ferrochelatase. Purification, properties, 
and stimulation by fatty acids. J Biol Chem. 1981 Dec 25;256(24):12748-53. PubMed
PMID: 7309736.

768: Hradilek A, Borová J, Fuchs O, Neuwirt J. The effect of heme on
intracellular iron pools during differentiation of Friend erythroleukemia cells. 
Biochim Biophys Acta. 1981 Dec 18;678(3):373-80. PubMed PMID: 6947826.

769: Kaneko K, Sanada M, Imaizumi S, Koike T, Miyashita M, Shibata A. [Decreased 
heme synthetase activity in erythroblasts in two patients with erythropoietic
protoporphyria (author's transl)]. Rinsho Ketsueki. 1981 Dec;22(12):2023-33.
Japanese. PubMed PMID: 7345186.

770: McColl KE, Moore MR, Thompson GG, Goldberg A. Abnormal haem biosynthesis in 
chronic alcoholics. Eur J Clin Invest. 1981 Dec;11(6):461-8. PubMed PMID:
6800821.

771: Ortiz de Montellano PR, Kunze KL, Cole SP, Marks GS. Differential inhibition
of hepatic ferrochelatase by the isomers of N-ethylprotoporphyrin IX. Biochem
Biophys Res Commun. 1981 Nov 30;103(2):581-6. PubMed PMID: 7332558.

772: Cole SP, Massey TE, Marks GS, Racz WJ. Effects of porphyrin-inducing drugs
on ferrochelatase activity in isolated mouse hepatocytes. Can J Physiol
Pharmacol. 1981 Nov;59(11):1155-8. PubMed PMID: 7317839.

773: Thiers BH. The porphyrias. J Am Acad Dermatol. 1981 Nov;5(5):621-5. PubMed
PMID: 7298935.

774: Healey JF, Bonkowsky HL, Sinclair PR, Sinclair JF. Conversion of
5-aminolaevulinate into haem by liver homogenates. Comparison of rat and chick
embryo. Biochem J. 1981 Sep 15;198(3):595-604. PubMed PMID: 7326026; PubMed
Central PMCID: PMC1163307.

775: Cole SP, Whitney RA, Marks GS. Ferrochelatase-inhibitory and
porphyrin-inducing properties of 3,5-diethoxycarbonyl-1,
4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells. 
Mol Pharmacol. 1981 Sep;20(2):395-403. PubMed PMID: 7300820.

776: Ortiz de Montellano PR, Beilan HS, Kunze KL. N-Alkylprotoporphyrin IX
formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the 
alkyl group from the substrate to the porphyrin. J Biol Chem. 1981 Jul
10;256(13):6708-13. PubMed PMID: 6894597.

777: De Matteis F, Gibbs AH, Farmer PB, Lamb JH. Liver production of N-alkylated 
porphyrins caused in mice by treatment with substituted dihydropyridines.
Evidence that the alkyl group on the pyrrole nitrogen atom originates from the
drug. FEBS Lett. 1981 Jul 6;129(2):328-31. PubMed PMID: 7286222.

778: Pasanen AV, Vuopio P, Borgström GH, Tenhunen R. Haem biosynthesis in
refractory sideroblastic anaemia associated with the preleukaemic syndrome. Scand
J Haematol. 1981 Jul;27(1):35-44. PubMed PMID: 7336157.

779: Bloomer JR. Enzyme defects in the porphyrias and their relevance to the
biochemical abnormalities in these disorders. J Invest Dermatol. 1981
Jul;77(1):102-6. PubMed PMID: 7252240.

780: Cole SP, Zelt DT, Marks GS. Comparison of the effects of griseofulvin and
3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase
activity in chick embryo liver. Mol Pharmacol. 1981 May;19(3):477-80. PubMed
PMID: 7266472.

781: Sassa S, Schwartz S, Ruth G. Accumulation of protoporphyrin IX from
delta-aminolevulinic acid in bovine skin fibroblasts with hereditary
erythropoietic protoporphyria. A gene-dosage effect. J Exp Med. 1981 May
1;153(5):1094-101. PubMed PMID: 6788885; PubMed Central PMCID: PMC2186152.

782: Pasanen AV. The activities of delta-aminolaevulinic acid synthase and haem
synthase in experimental sideroblastic anaemia. Effect of mitochondrial iron
excess on the enzyme activity in peripheral red blood cells. Scand J Clin Lab
Invest. 1981 Apr;41(2):159-65. PubMed PMID: 7313498.

783: Denk H, Kalt R, Abdelfattach-Gad M, Meyer UA. Effect of Griseofulvin on
5-aminolevulinate synthase and on ferrochelatase in mouse liver neoplastic
nodules. Cancer Res. 1981 Apr;41(4):1535-8. PubMed PMID: 7214331.

784: Eida K, Fukunaga K, Nishiyori T, Kikutani M. [Purification of protoheme
ferro-lyase from rat liver mitochondria (author's transl)]. Yakugaku Zasshi. 1981
Mar;101(3):291-3. Japanese. PubMed PMID: 7299641.

785: Ortiz de Montellano PR, Beilan HS, Kunze KL. N-Methylprotoporphyrin IX:
chemical synthesis and identification as the green pigment produced by
3,5-diethoxycarbonyl-1,4-dihydrocollidine treatment. Proc Natl Acad Sci U S A.
1981 Mar;78(3):1490-4. PubMed PMID: 6940170; PubMed Central PMCID: PMC319156.

786: Lee WR. What happens in lead poisoning? J R Coll Physicians Lond. 1981
Jan;15(1):48-54. PubMed PMID: 7463387.

787: Deybach JC, de Verneuil H, Nordmann Y. The inherited enzymatic defect in
porphyria variegata. Hum Genet. 1981;58(4):425-8. PubMed PMID: 7327566.

788: Hradilek A, Fuchs O, Borová J, Neuwirt J. The role of heme in the regulation
of iron uptake during Friend cell differentiation. Acta Biol Med Ger.
1981;40(4-5):519-23. PubMed PMID: 7315097.

789: Urban-Grimal D, Labbe-Bois R. Genetic and biochemical characterization of
mutants of Saccharomyces cerevisiae blocked in six different steps of heme
biosynthesis. Mol Gen Genet. 1981;183(1):85-92. PubMed PMID: 7035824.

790: Camadro JM, Labbe P. A simple ferrochelatase assay. Biochimie.
1981;63(5):463-5. PubMed PMID: 7016197.

791: Fuchs O, Hradilek A, Borová J, Neuwirt J, Trávnícek M. Effect of heme on
globin messenger RNA synthesis. Acta Biol Med Ger. 1981;40(7-8):915-25. PubMed
PMID: 6949418.

792: Canepa ET, Llambias EB. Properties of the cobaltochelatase and the
ferrochelatase. Enzyme. 1981;26(6):288-95. PubMed PMID: 6796410.

793: Ortiz de Montellano PR, Kunze KL, Cole SP, Marks GS. Inhibition of hepatic
ferrochelatase by the four isomers of N-methylprotoporphyrin IX. Biochem Biophys 
Res Commun. 1980 Dec 31;97(4):1436-42. PubMed PMID: 6894236.

794: Mailer K, Poulson R, Dolphin D, Hamilton AD. Ferrochelatase: isolation and
purification via affinity chromatography. Biochem Biophys Res Commun. 1980 Sep
30;96(2):777-84. PubMed PMID: 7426014.

795: De Matteis F, Gibbs AH, Smith AG. Inhibition of protohaem ferro-lyase by
N-substituted porphyrins. Structural requirements for the inhibitory effect.
Biochem J. 1980 Sep 1;189(3):645-8. PubMed PMID: 7213349; PubMed Central PMCID:
PMC1162046.

796: Lubran MM. Lead toxicity and heme biosynthesis. Ann Clin Lab Sci. 1980
Sep-Oct;10(5):402-13. Review. PubMed PMID: 6999974.

797: Moore MR. The biochemistry of the porphyrins. Clin Haematol. 1980
Jun;9(2):227-52. Review. PubMed PMID: 6994963.

798: De Matteis F, Gibbs AH, Tephly TR. Inhibition of protohaem ferro-lyase in
experimental porphyria. Isolation and partial characterization of a modified
porphyrin inhibitor. Biochem J. 1980 Apr 15;188(1):145-52. PubMed PMID: 7406876; 
PubMed Central PMCID: PMC1162549.

799: Brenner DA, Bloomer JR. The enzymatic defect in variegate prophyria. Studies
with human cultured skin fibroblasts. N Engl J Med. 1980 Apr 3;302(14):765-9.
PubMed PMID: 7354807.

800: De Matteis F, Gibbs AH. Drug-induced conversion of liver haem into modified 
porphyrins. Evidence for two classes of products. Biochem J. 1980 Apr
1;187(1):285-8. PubMed PMID: 7406869; PubMed Central PMCID: PMC1162524.

801: McColl KE, Thompson GG, Moore MR, Goldberg A. Acute ethanol ingestion and
haem biosynthesis in healthy subjects. Eur J Clin Invest. 1980 Apr;10(2 Pt
1):107-12. PubMed PMID: 6780356.

802: Tangerås A, Flatmark T, Bäckström D, Ehrenberg A. Mitochondrial iron not
bound in heme and iron-sulfur centers. Estimation, compartmentation and redox
state. Biochim Biophys Acta. 1980 Feb 8;589(2):162-75. PubMed PMID: 6243966.

803: Bloomer JR. Characterization of deficient heme synthase activity in
protoporphyria with cultured skin fibroblasts. J Clin Invest. 1980
Feb;65(2):321-8. PubMed PMID: 7356682; PubMed Central PMCID: PMC371370.

804: Tephly TR, Gibbs AH, Ingall G, De Matteis F. Studies on the mechanism of
experimental porphyria and ferrochelatase inhibition produced by
3,5-diethoxycarbonyl-1,4-dihydrocollidine. Int J Biochem. 1980;12(5-6):993-8.
PubMed PMID: 7450161.

805: Cole SP, Marks GS. Structural requirements in dihydropyridines for
ferrochelatase inhibition and delta-aminolevulinic acid synthetase induction. Int
J Biochem. 1980;12(5-6):989-92. PubMed PMID: 7450160.

806: Pasanen AV, Salmi M, Vuopio P, Tenhunen R. Heme biosynthesis in
sideroblastic anemia. Int J Biochem. 1980;12(5-6):969-74. PubMed PMID: 7450158.

807: Schwartz S, Raux WA, Schacter BA, Stephenson BD, Shoffner RN. Loss of
hereditary uterine protoporphyria through chromosomal rearrangement in mutant
Rhode Island red hens. Int J Biochem. 1980;12(5-6):935-40. PubMed PMID: 7450152.

808: Kramer S, Viljoen JD. Erythropoietic protoporphyria: evidence that it is due
to a variant ferrochelatase. Int J Biochem. 1980;12(5-6):925-30. PubMed PMID:
7450150.

809: Williams HL, Johnson DJ, Haut MJ, Slater S, Brennan RG, Altstatt LB.
Improved radiochemical method for measuring ferrochelatase activity. Clin Chem.
1980 Jan;26(1):153-6. PubMed PMID: 7356552.

810: Buchanan GR, Bottomley SS, Nitschke R. Bone marrow delta-aminolaevulinate
synthase deficiency in a female with congenital sideroblastic anemia. Blood. 1980
Jan;55(1):109-15. PubMed PMID: 7350930.

811: Grabowska AM, Winter R, Piskorska D. [Effect of toxohormone, endogenic or
isolated from melanoma, on the activity of liver ferrochelatase in the Syrian
hamster]. Patol Pol. 1980;31(1):19-24. Polish. PubMed PMID: 7190261.

812: Cole SP, Vavasour EJ, Marks GS. Drug-induced porphyrin biosynthesis--XIX.
Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo
liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor
of ferrochelatase. Biochem Pharmacol. 1979 Dec 15;28(24):0533-8. PubMed PMID:
533555.

813: Percy VA, Shanley BC. Studies on haem biosynthesis in rat brain. J
Neurochem. 1979 Dec;33(6):1267-74. PubMed PMID: 552404.

814: Moore MR, McColl KE, Goldberg A. The porphyrias. Diabete Metab. 1979
Dec;5(4):323-36. Review. PubMed PMID: 398301.

815: Goerz G. [Erythropoietic protoporphyria]. Fortschr Med. 1979 Oct
4;97(37):1625-30. German. PubMed PMID: 499971.

816: Merino RA, Wolff C. [Phlebotomy in porphyria cutanea tarda (author's
transl)]. Rev Med Chil. 1979 Sep;107(9):838-41. Spanish. PubMed PMID: 542750.

817: Straka JG, Emery T. The role of ferrichrome reductase in iron metabolism of 
Ustilago sphaerogena. Biochim Biophys Acta. 1979 Aug 15;569(2):277-86. PubMed
PMID: 224934.

818: Săsărman A, Chartrand P, Lavoie M, Tardif D, Proschek R, Lapointe C. Mapping
of a new hem gene in Escherichia coli K12. J Gen Microbiol. 1979
Aug;113(2):297-303. PubMed PMID: 390093.

819: McConville ML, Charles HP. Isolation of haemin-requiring mutants of
Escherichia coli K12. J Gen Microbiol. 1979 Jul;113(1):155-64. PubMed PMID:
387909.

820: Rifkind AB. Maintenance of microsomal hemoprotein concentrations following
inhibition of ferrochelatase activity by
3,5-diethoxycarbonyl-1,4-dihydrocollidine in chick embryo liver. J Biol Chem.
1979 Jun 10;254(11):4636-44. PubMed PMID: 571439.

821: Wolfson SJ, Bartczak A, Bloomer JR. Effect of endogenous heme generation on 
delta-aminolevulinic acid synthase activity in rat liver mitochondria. J Biol
Chem. 1979 May 10;254(9):3543-6. PubMed PMID: 429369.

822: Morgan RO, Naglie G, Horrobin DF, Barbeau A. Erythrocyte protoporphyrin
levels in patients with Friedreich's and other ataxias. Can J Neurol Sci. 1979
May;6(2):227-32. PubMed PMID: 487315.

823: Konopka L, Hoffbrand AV. Haem synthesis in sideroblastic anaemia. Br J
Haematol. 1979 May;42(1):73-83. PubMed PMID: 465361.

824: Carpentieri U, Buck ED, Minguell JJ, Balachandran S, Haggard ME.
Ferrochelatase deficiency in an infant with anemia and growth delay. Pediatrics. 
1979 May;63(5):757-60. PubMed PMID: 440897.

825: Brodie MJ, Thompson GG, Moore MR, McColl KE, Goldberg A, Hardie RA, Hunter
JA. Haem biosynthesis in cutaneous hepatic porphyria: comparison with alcoholism 
and liver disease. Acta Hepatogastroenterol (Stuttg). 1979 Apr;26(2):122-8.
PubMed PMID: 463487.

826: Honeybourne CL, Jackson JT, Jones OT. The interaction of mitochondrial
ferrochelatase with a range of porphyrin substrates. FEBS Lett. 1979 Feb
1;98(1):207-10. PubMed PMID: 428538.

827: Rutherford TR, Weatherall DJ. Deficient heme synthesis as the cause of
noninducibility of hemoglobin synthesis in a Friend erythroleukemia cell line.
Cell. 1979 Feb;16(2):415-23. PubMed PMID: 287566.

828: Rutherford T, Thompson GG, Moore MR. Heme biosynthesis in Friend
erythroleukemia cells: control by ferrochelatase. Proc Natl Acad Sci U S A. 1979 
Feb;76(2):833-6. PubMed PMID: 284406; PubMed Central PMCID: PMC383066.

829: Sassa S, Zalar GL, Poh-Fitzpatrick MB, Kappas A. Studies in porphyria IX:
Detection of the gene defect of erythropoietic protoporphyria in
mitogen-stimulated human lymphocytes. Trans Assoc Am Physicians. 1979;92:268-76. 
PubMed PMID: 549253.

830: Viljoen DJ, Cayanis E, Becker DM, Kramer S, Dawson B, Bernstein R. Reduced
ferrochelatase activity in fibroblasts from patients with porphyria variegata. Am
J Hematol. 1979;6(3):185-90. PubMed PMID: 484541.

831: Bloomer JR. Pathogenesis and therapy of liver disease in protoporphyria.
Yale J Biol Med. 1979 Jan-Feb;52(1):39-48. PubMed PMID: 452621; PubMed Central
PMCID: PMC2595712.

832: Linkesch W, Müller M, Scherak O. [New aspects in the pathogenesis of anemia 
in chronic polyarthritis]. Acta Med Austriaca Suppl. 1979;6:387-9. German. PubMed
PMID: 299239.

833: Linkesch W, Pavelka R, Kofler E, Müller M. [Heme synthesis and iron status
in pregnancy]. Acta Med Austriaca Suppl. 1979;6:368-72. German. PubMed PMID:
299236.

834: Campbell BC, Rennie N, Thompson GG, Moore MR, Goldberg A. Haem biosynthesis 
in rheumatoid disease. Br J Haematol. 1978 Dec;40(4):563-9. PubMed PMID: 728373.

835: Linkesch W, Stummvoll HK, Wolf A, Müller M. Heme synthesis in anemia of the 
uremic state. Isr J Med Sci. 1978 Nov;14(11):1173-6. PubMed PMID: 750546.

836: Barnekow A, Winkelmann G. Use of iron from transferrin and microbial
chelates as substrate for heme synthetase in transformed and primary erythroid
cell cultures. Biochim Biophys Acta. 1978 Nov 1;543(4):530-5. PubMed PMID:
281251.

837: Anderson KE. Effects of antihypertensive drugs on hepatic heme biosynthesis,
and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme
pathway induction. Biochim Biophys Acta. 1978 Oct 18;543(3):313-27. PubMed PMID: 
708789.

838: Romslo I, Høvding G, Hamre E, Laerum OD. Porphyrin production and liver
involvement in a patient with erythropoietic protoporphyria. Scand J Clin Lab
Invest. 1978 Oct;38(6):529-35. PubMed PMID: 705235.

839: Whetsell WO Jr, Sassa S, Bickers D, Kappas A. Studies on porphyrin-heme
biosynthesis in organotypic cultures of chick dorsal root ganglion. I.
Observations on neuronal and non-neuronal elements. J Neuropathol Exp Neurol.
1978 Sep;37(5):497-507. PubMed PMID: 567682.

840: Koller ME, Romslo I. Studies on the uptake of porphyrin by isolated rat
liver mitochondria. Biochim Biophys Acta. 1978 Aug 8;503(2):238-50. PubMed PMID: 
687606.

841: Barrett J, Jones OT. Localization of ferrochelatase and of newly synthesized
haem in membrane fractions from Rhodopseudomonas spheroides. Biochem J. 1978 Jul 
15;174(1):277-81. PubMed PMID: 308802; PubMed Central PMCID: PMC1185907.

842: Ulvik R, Romslo I. Studies on the utilization of ferritin iron in the
ferrochelatase reaction of isolated rat liver mitochondria. Biochim Biophys Acta.
1978 Jun 15;541(2):251-62. PubMed PMID: 208637.

843: Schenk J. [The hepatic porphyrias]. Fortschr Med. 1978 Jun 8;96(22):1161-6. 
German. PubMed PMID: 658866.

844: Calabrese EJ. Will elevated levels of lead exposure precipitate clinical
symptoms of porphyria in individuals with the latent condition? Med Hypotheses.
1978 May-Jun;4(3):282-9. PubMed PMID: 672715.

845: Maines MD, Kappas A. Prematurely evoked synthesis and induction of
delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion
repression of enzyme formation. J Biol Chem. 1978 Apr 10;253(7):2321-6. PubMed
PMID: 637921.

846: Goldberg A, Meredith PA, Miller S, Moore MR, Thompson GG. Hepatic drug
metabolism and haem biosynthesis in lead-poisoned rats. Br J Pharmacol. 1978
Apr;62(4):529-36. PubMed PMID: 656697; PubMed Central PMCID: PMC1668043.

847: Rikans LE, Smith CR, Zannoni VG. Ascorbic acid and cytochrome P-450. J
Pharmacol Exp Ther. 1978 Mar;204(3):702-13. PubMed PMID: 633074.

848: Sassa S, Zalar GL, Kappas A. Studies in porphyria. VII. Induction of
uroporphyrinogen-I synthase and expression of the gene defect of acute
intermittent porphyria in mitogen-stimulated human lymphocytes. J Clin Invest.
1978 Feb;61(2):499-508. PubMed PMID: 621286; PubMed Central PMCID: PMC372561.

849: Verhoef NJ, Noordeloos PJ, Leijnse B. Heme synthetase activity in normal
human and rat erythroid cells and in sideroblastic anemia. Clin Chim Acta. 1978
Jan 2;82(1-2):45-53. PubMed PMID: 618683.

850: Löhr GW. [Sideroblastic anemias]. Verh Dtsch Ges Inn Med. 1978;(84):71-8.
Review. German. PubMed PMID: 369209.

851: Tephly TR, Wagner G, Sedman R, Piper W. Effects of metals on heme
biosynthesis and metabolism. Fed Proc. 1978 Jan;37(1):35-9. Review. PubMed PMID: 
338364.

852: Meyer UA. Drug sensitivity in hereditary hepatic porphyria. Hum Genet Suppl.
1978;(1):71-8. PubMed PMID: 285036.

853: Denk H, Eckerstorfer R. [Experimental protoporphyria and hepatoma]. Verh
Dtsch Ges Pathol. 1978;62:358. German. PubMed PMID: 218386.

854: Maines MD, Kappas A. Enzymes of heme metabolism in the kidney: regulation by
trace metals which do not form heme complexes. J Exp Med. 1977 Nov
1;146(5):1286-93. PubMed PMID: 925603; PubMed Central PMCID: PMC2180983.

855: Burk RF, Correia MA. Accelerated hepatic haem catabolism in the
selenium-deficient rat. Biochem J. 1977 Oct 15;168(1):105-11. PubMed PMID:
597257; PubMed Central PMCID: PMC1184121.

856: RUTH GR, Schwartz S, Stephenson B. Bovine protoporphyria: the first nonhuman
model of this hereditary photosensitizing disease. Science. 1977 Oct
14;198(4313):199-201. PubMed PMID: 905823.

857: Brodie MJ, Moore MR, Thompson GG, Goldberg A. The treatment of acute
intermittent prophyria with laevulose. Clin Sci Mol Med. 1977 Oct;53(4):365-71.
PubMed PMID: 913061.

858: Campbell BC, Brodie MJ, Thompson GG, Meredith PA, Moore MR, Goldberg A.
Alterations in the activity of enzymes of haem biosynthesis in lead poisoning and
acute hepatic prophyria. Clin Sci Mol Med. 1977 Oct;53(4):335-40. PubMed PMID:
913057.

859: Gribble TJ, Edmunds D, Schwartz HC. Hemoglobin synthesis in a rabbit
ribosomal system: localization of heme synthetase activity. Pediatr Res. 1977
Oct;11(10 Pt 2):1106-8. PubMed PMID: 904976.

860: Brodie MJ, Moore MR, Goldberg A. Enzyme abnormalities in the porphyrias.
Lancet. 1977 Oct 1;2(8040):699-701. PubMed PMID: 71507.

861: Dailey HA Jr. Purification and characterization of the membrane-bound
ferrochelatase from Spirillum itersonii. J Bacteriol. 1977 Oct;132(1):302-7.
PubMed PMID: 21163; PubMed Central PMCID: PMC221856.

862: Meredith PA, Moore MR, Goldberg A. The effect of calcium on lead absorption 
in rats. Biochem J. 1977 Sep 15;166(3):531-7. PubMed PMID: 597243; PubMed Central
PMCID: PMC1165037.

863: Sáez de Córdova C, Cohén R, González-Cadavid NF. Synthesis of haem and
cytochrome c prosthetic group from delta-aminolaevulinate by the cell sap from
rat liver. Biochem J. 1977 Sep 15;166(3):305-13. PubMed PMID: 202245; PubMed
Central PMCID: PMC1165011.

864: Woods JS, Carver GT. Action of cobalt chloride on the biosynthesis,
degradation, and utilization of heme in fetal rat liver. Drug Metab Dispos. 1977 
Sep-Oct;5(5):487-92. PubMed PMID: 20299.

865: Koller ME, Romslo I. Studies on the ferrochelatase activity of mitochondria 
and submitochondrial particles with special refefence to the regulatory function 
of the mitochondrial inner membrane. Biochim Biophys Acta. 1977 Aug
10;461(2):283-96. PubMed PMID: 19059.

866: Woods JS, Fowler BA. Effects of chronic arsenic exposure on hematopoietic
function in adult mammalian liver. Environ Health Perspect. 1977 Aug;19:209-13.
PubMed PMID: 908300; PubMed Central PMCID: PMC1637394.

867: Woods JS, Fowler BA. Renal porphyrinuria during chronic methyl mercury
exposure. J Lab Clin Med. 1977 Aug;90(2):266-72. PubMed PMID: 886212.

868: Simpson DM, Poulson R. Effects of lipids on the activity of ferrochelatase. 
Biochim Biophys Acta. 1977 Jun 10;482(2):461-9. PubMed PMID: 406931.

869: Becker DM, Viljoen JD, Katz J, Kramer S. Reduced ferrochelatase activity: a 
defect common to porphyria variegata and protoporphyria. Br J Haematol. 1977
Jun;36(2):171-9. PubMed PMID: 871431.

870: Badawy AA. The effects of acetate, metal cations, phenobarbitone,
porphyrogens and substrates of glycine acyltransferase on the utilization of haem
by rat liver apo-(tryptophan pyrrolase). Biochem J. 1977 May 15;164(2):431-8.
PubMed PMID: 880248; PubMed Central PMCID: PMC1164809.

871: Gollub EG, Liu KP, Dayan J, Adlersberg M, Sprinson DB. Yeast mutants
deficient in heme biosynthesis and a heme mutant additionally blocked in
cyclization of 2,3-oxidosqualene. J Biol Chem. 1977 May 10;252(9):2846-54. PubMed
PMID: 323256.

872: Maines MD, Kappas A. Regulation of heme pathway enzymes and cellular
glutathione content by metals that do not chelate with tetrapyrroles: blockade of
metal effects by thiols. Proc Natl Acad Sci U S A. 1977 May;74(5):1875-8. PubMed 
PMID: 266710; PubMed Central PMCID: PMC431034.

873: Rikans LE, Smith CR, Zannoni VG. Ascorbic acid and heme synthesis in
deficient guinea pig liver. Biochem Pharmacol. 1977 Apr 15;26(8):797-9. PubMed
PMID: 856210.

874: Brodie MJ, Thompson GG, Moore MR, Beattie AD, Goldberg A. Hereditary
coproporphyria. Demonstration of the abnormalities in haem biosynthesis in
peripheral blood. Q J Med. 1977 Apr;46(182):229-41. PubMed PMID: 866576.

875: Labbe-Bois R, Volland C. Changes in the activities of the
protoheme-synthesizing system during the growth of yeast under different
conditions. Arch Biochem Biophys. 1977 Mar;179(2):565-77. PubMed PMID: 192152.

876: Labbé RF. History and background of protoporphyrin testing. Clin Chem. 1977 
Feb;23(2 PT. 1):256-9. PubMed PMID: 832388.

877: Dailey HA Jr, Lascelles J. Reduction of iron and synthesis of protoheme by
Spirillum itersonii and other organisms. J Bacteriol. 1977 Feb;129(2):815-20.
PubMed PMID: 190208; PubMed Central PMCID: PMC235016.

878: Kushner JP, Cartwright GE. Sideroblastic anemia. Adv Intern Med.
1977;22:229-49. Review. PubMed PMID: 320843.

879: Koller ME, Romslo I, Flatmark T. Studies on the ferrochelatase activity of
isolated rat liver mitochondria with special reference to the effect of
oxidizable substrates and oxygen concentration. Biochim Biophys Acta. 1976 Dec
6;449(3):480-90. PubMed PMID: 11817.

880: Tanaka S, Nagahama S, Takeshita M, Yoneyama Y. Molecular weight estimation
of protoheme ferro-lyase by radiation inactivation. J Biochem. 1976
Nov;80(5):1067-71. PubMed PMID: 1033934.

881: Miczák A, Berek I, Ivanovics G. Mapping the uroporphyrinogen decarboxylase, 
coproporphyrinogen oxidase and ferrochelatase loci in Bacillus subtilis. Mol Gen 
Genet. 1976 Jul 5;146(1):85-7. PubMed PMID: 822275.

882: Little HN, Jones OT. The subcellular loclization and properties of the
ferrochelatase of etiolated barley. Biochem J. 1976 May 15;156(2):309-14. PubMed 
PMID: 182145; PubMed Central PMCID: PMC1163750.

883: Sassa S. Sequential induction of heme pathway enzymes during erythroid
differentiation of mouse Friend leukemia virus-infected cells. J Exp Med. 1976
Feb 1;143(2):305-15. PubMed PMID: 1249519; PubMed Central PMCID: PMC2190112.

884: Schermuly E, Doss M. Porphyrin biosynthesis from ALA and PBG by human
erythrocytes in porphyrin disorders. Kinetic studies of the isomer series I and
III. Ann Clin Res. 1976;8 Suppl 17:92-102. PubMed PMID: 1008503.

885: De Matteis F, Gibbs AH. The effect of cobaltous chloride on liver haem
metabolism in the rat. Evidence for inhibition of haem synthesis and for
increased haem degradation. Ann Clin Res. 1976;8 Suppl 17:193-7. PubMed PMID:
1008489.

886: Poulson R. The regulation of heme biosynthesis. Ann Clin Res. 1976;8 Suppl
17:56-63. PubMed PMID: 188375.

887: Moore MR, Meredith PA, Goldberg A, Carr KE, Toner PG, Lawrie TD. Cardiac
effects of lead in drinking water of rats. Clin Sci Mol Med. 1975
Oct;49(4):337-41. PubMed PMID: 1192693.

888: Porra RJ. A rapid spectrophotometric assay for ferrochelatase activity in
preparations containing much endogenous hemoglobin and its application to soybean
root-nodule preparations. Anal Biochem. 1975 Sep;68(1):289-98. PubMed PMID:
1238032.

889: Nakamura M, Yasukochi Y, Minakami S. Effect of cobalt on heme biosynthesis
in rat liver and spleen. J Biochem. 1975 Aug;78(2):373-80. PubMed PMID: 1228174.

890: Chang KP, Chang CS, Sassa S. Heme biosynthesis in bacterium-protozoon
symbioses: enzymic defects in host hemoflagellates and complemental role of their
intracellular symbiotes. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2979-83. PubMed
PMID: 810795; PubMed Central PMCID: PMC432902.

891: Bottomley SS, Tanaka M, Everett MA. Diminished erythroid ferrochelatase
activity in protoporphyria. J Lab Clin Med. 1975 Jul;86(1):126-31. PubMed PMID:
1151134.

892: Wagner GS, Tephly TR. A possible role of copper in the regulation of heme
biosynthesis through ferrochelatase. Adv Exp Med Biol. 1975;58(00):343-54. PubMed
PMID: 1155252.

893: Dailey HA Jr, Lascelles J. Ferrochelatase activity in wild-type and mutant
strains of Spirillum itersonii. Solubilization with chaotropic reagents. Arch
Biochem Biophys. 1974 Feb;160(2):523-9. PubMed PMID: 4364772.

894: Druyan R, Jakovcic S, Rabinowitz M. Studies of cytochrome synthesis in rat
liver. Biochem J. 1973 Jun;134(2):377-385. PubMed PMID: 16742796; PubMed Central 
PMCID: PMC1177822.

895: Kassner RJ, Walchak H. Heme formation from Fe(II) and porphyrin in the
absence of ferrochelatase activity. Biochim Biophys Acta. 1973 Apr
28;304(2):294-303. PubMed PMID: 4710757.

896: Porra RJ, Langman L, Young IG, Gibson F. The role of ferric enterochelin
esterase in enterochelin-mediated iron transport and ferrochelatase activity in
Escherichia coli. Arch Biochem Biophys. 1972 Nov;153(1):74-8. PubMed PMID:
4568262.

897: Barnes R, Connelly JL, Jones OT. The utilization of iron and its complexes
by mammalian mitochondria. Biochem J. 1972 Aug;128(5):1043-55. PubMed PMID:
4345350; PubMed Central PMCID: PMC1173992.

898: De Matteis F, Gibbs A. Stimulation of liver 5-aminolaevulinate synthetase by
drugs and its relevance to drug-induced accumulation of cytochrome P-450. Studies
with phenylbutazone and 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Biochem J.
1972 Mar;126(5):1149-60. PubMed PMID: 5073727; PubMed Central PMCID: PMC1178538.

899: Manyan DR, Arimura GK, Yunis AA. Chloramphenicol-induced erythroid
suppression and bone marrow ferrochelatase activity in dogs. J Lab Clin Med. 1972
Jan;79(1):137-44. PubMed PMID: 5007558.

900: Mazanowska A, Dancewicz A. [Properties of ferrochelatase]. Acta Physiol Pol.
1971 Nov-Dec;22(6):843-6. Polish. PubMed PMID: 5152823.

901: Barnes R, Jones MS, Jones OT, Porra RJ. Ferrochelatase and -aminolaevulate
synthetase in brain, heart, kidney and liver of normal and porphyric rats. The
induction of -aminolaevulate synthetase in kidney cytosol and mitochondria by
allylisopropylacetamide. Biochem J. 1971 Sep;124(3):633-7. PubMed PMID: 5135247; 
PubMed Central PMCID: PMC1177233.

902: Manyan DR, Yunis AA. The effect of chloramphenicol treatment on
ferrochelatase activity in dogs. Biochem Biophys Res Commun. 1970 Nov
25;41(4):926-31. PubMed PMID: 5477228.

903: Jones MS, Jones OT. Ferrochelatase of Rhodopseudomonas spheroides. Biochem
J. 1970 Sep;119(3):453-62. PubMed PMID: 5500305; PubMed Central PMCID:
PMC1179374.

904: Hasegawa E, Smith C, Tephly TR. Induction of hepatic mitochondrial
ferrochelatase by phenobarbital. Biochem Biophys Res Commun. 1970 Aug
11;40(3):517-23. PubMed PMID: 5492148.

905: Jones MS, Jones OT. Properties of ferrochelatase in micro-organisms adapting
to changes in growth conditions. Biochem J. 1970 Feb;116(4):19P. PubMed PMID:
5435454; PubMed Central PMCID: PMC1185448.

906: Mazanowska A, Dancewicz AM. The role of lipids in ferrochelatase activity.
Acta Biochim Pol. 1970;17(1):1-10. PubMed PMID: 5441325.

907: Palma-Carlos AG, Palma-Carlos ML. [Effect of the concentration of iron and
pyridoxal phosphate on the ferrochelatase activity of erythrocytes]. Sangre
(Barc). 1970;15(2):186-98. Spanish. PubMed PMID: 5431821.

908: Birkmayer GD, Bücher T. Ferrochelatase in wild-type and in cytoplasmic
mutants of neurospora crassa. FEBS Lett. 1969 Sep;5(1):28-30. PubMed PMID:
11947230.

909: McKay R, Druyan R, Getz GS, Rabinowitz M. Intramitochondrial localization of
delta-aminolaevulate synthetase and ferrochelatase in rat liver. Biochem J. 1969 
Sep;114(3):455-61. PubMed PMID: 5820634; PubMed Central PMCID: PMC1184917.

910: Jones MS, Jones OT. The structural organization of haem synthesis in rat
liver mitochondria. Biochem J. 1969 Jul;113(3):507-14. PubMed PMID: 4308946;
PubMed Central PMCID: PMC1184693.

911: King RF, Page ER. Ferrochelatase of lettuce chloroplasts. Biochem J. 1968
Dec;110(4):45P. PubMed PMID: 5704797; PubMed Central PMCID: PMC1187460.

912: Mazur A. Metabolism of the stimulated rat spleen. I. Ferrochelatase activity
as an index of tissue erythropoiesis. J Clin Invest. 1968 Oct;47(10):2230-8.
PubMed PMID: 5676519; PubMed Central PMCID: PMC297387.

913: Labbe P, Volland C, Chaix P. [Study of the ferrochelatase activity of yeast 
mitochondria]. Biochim Biophys Acta. 1968 Jul 9;159(3):527-39. Greek, Modern.
PubMed PMID: 5661033.

914: Jones MS, Jones OT. Evidence for the location of ferrochelatase on the inner
membrane of rat liver mitochondria. Biochem Biophys Res Commun. 1968 Jun
28;31(6):977-82. PubMed PMID: 5668190.

915: Porra RJ, Lascelles J. Studies on ferrochelatase. The enzymic formation of
haem in proplastids, chloroplasts and plant mitochondria. Biochem J. 1968
Jun;108(2):343-8. PubMed PMID: 4298995; PubMed Central PMCID: PMC1198814.

916: Jones OT. Ferrochelatase of spinach chloroplasts. Biochem J. 1968
Mar;107(1):113-9. PubMed PMID: 5642615; PubMed Central PMCID: PMC1198618.

917: Goudy B, Dawes E, Wilkinson AE, Wills ED. Ferrochelatase activity in normal 
and irradiated animal tissues. Eur J Biochem. 1967 Dec;3(2):208-12. PubMed PMID: 
6082610.

918: Porra RJ, Vitols KS, Labbe RF, Newton NA. Studies on ferrochelatase. The
effects of thiols and other factors on the determination of activity. Biochem J. 
1967 Aug;104(2):321-7. PubMed PMID: 6048771; PubMed Central PMCID: PMC1270590.

919: Rasetti L, Pisani W, Perrelli G. [Ferrochelatase, ALA-dehydrase and
ALA-synthetase activities in normal human tissues]. Arch Sci Med (Torino). 1967
May;123(5):219-24. Italian. PubMed PMID: 5624596.

920: Rasetti L, Rubino GF, Drago W. Ferrochelatase, ALA-dehydrase and
ALA-synthetase activity in human tumour tissue. Panminerva Med. 1967
Apr;9(4):132-5. PubMed PMID: 6047101.

921: Rasetti L, Rubino GF, Drago W. [Ferrochelatase, ALA-dehydrase and
ALA-synthetase activity in human tumor tissues]. Minerva Med. 1966 Sep
1;57(70):2834-7. Italian. PubMed PMID: 5917926.

922: PORRA RJ, LASCELLES J. HAEMOPROTEINS AND HAEM SYNTHESIS IN FACULTATIVE
PHOTOSYNTHETIC AND DENITRIFYING BACTERIA. Biochem J. 1965 Jan;94:120-6. PubMed
PMID: 14342218; PubMed Central PMCID: PMC1206416.

923: RIETHMUELLER G, TUPPY H. [HEME SYNTHETASE (FERROCHELATASE) IN SACCHAROMYCES 
CEREVISIAE AFTER AEROBIC AND ANAEROBIC GROWTH.]. Biochem Z. 1964 Sep
28;340:413-20. German. PubMed PMID: 14317972.

924: PORRA RJ, JONES OT. Studies on ferrochelatase. 2. An in vestigation of the
role offerrochelatase in the biosynthesis of various haem prosthetic groups.
Biochem J. 1963 Apr;87:186-92. PubMed PMID: 13972329; PubMed Central PMCID:
PMC1276859.

925: PORRA RJ, JONES OT. Studies on ferrochelatase. 1. Assay and properties of
ferrochelatase from a pig-liver mitochondrial extract. Biochem J. 1963
Apr;87:181-5. PubMed PMID: 13972328; PubMed Central PMCID: PMC1276858.