ID A0A058ZVM6_EUCGR Unreviewed; 857 AA. AC A0A058ZVM6; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KCW45479.1}; GN ORFNames=EUGRSUZ_L00809 {ECO:0000313|EMBL:KCW45479.1}; OS Eucalyptus grandis (Flooded gum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; OC Eucalypteae; Eucalyptus. OX NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW45479.1, ECO:0000313|Proteomes:UP000030711}; RN [1] {ECO:0000313|Proteomes:UP000030711} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24919147; DOI=10.1038/nature13308; RA Myburg A.A., Grattapaglia D., Tuskan G.A., Hellsten U., Hayes R.D., RA Grimwood J., Jenkins J., Lindquist E., Tice H., Bauer D., RA Goodstein D.M., Dubchak I., Poliakov A., Mizrachi E., Kullan A.R., RA Hussey S.G., Pinard D., van der Merwe K., Singh P., van Jaarsveld I., RA Silva-Junior O.B., Togawa R.C., Pappas M.R., Faria D.A., RA Sansaloni C.P., Petroli C.D., Yang X., Ranjan P., Tschaplinski T.J., RA Ye C.Y., Li T., Sterck L., Vanneste K., Murat F., Soler M., RA Clemente H.S., Saidi N., Cassan-Wang H., Dunand C., Hefer C.A., RA Bornberg-Bauer E., Kersting A.R., Vining K., Amarasinghe V., Ranik M., RA Naithani S., Elser J., Boyd A.E., Liston A., Spatafora J.W., RA Dharmwardhana P., Raja R., Sullivan C., Romanel E., Alves-Ferreira M., RA Kulheim C., Foley W., Carocha V., Paiva J., Kudrna D., RA Brommonschenkel S.H., Pasquali G., Byrne M., Rigault P., Tibbits J., RA Spokevicius A., Jones R.C., Steane D.A., Vaillancourt R.E., RA Potts B.M., Joubert F., Barry K., Pappas G.J., Strauss S.H., RA Jaiswal P., Grima-Pettenati J., Salse J., Van de Peer Y., RA Rokhsar D.S., Schmutz J.; RT "The genome of Eucalyptus grandis."; RL Nature 509:356-362(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK198815; KCW45479.1; -; Genomic_DNA. DR Proteomes; UP000030711; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS51450; LRR; 4. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030711}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030711}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 6 147 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 857 AA; 97339 MW; EA8C7349F79C8831 CRC64; MDSSEKNYHV FVSFRGTDVR NNFLRDLYAA LKQEGIYTFV DSEELRKGEQ ISPALMRAIE ESRVTIIIFS EDYASSPWCL DELAKIMECK AQKELIVLPV FYKVEPREVR RGRKGYGIAM TKHEKDPEKD QKSVETWKKV LFEAGSLSGW ACNDGDEAEV IQSIVKELLI HLERTPLHVA EYPVGIDSRV EKIISLSQKK LDDDDTLMIG IWGSGGVGKT TIAKAIYNAI ESQFQGAIFL ERVRETSNKC GGLVELQKRL LSQILPPKHL AVYSVAEGAS LIKERLCCKK VLLILDDVDH SCQLDTLAGG GNWFGKGSRI FVTTRDKRLV VSSHCLNCVY PVKTLEDDDA LALFVWHAFQ NSEKSGIRKD LINRAVHYAS GLPLALEVLG SFLRGRNEPA WESELRKLSK SPDKDINQVL KISFDGLEND QKEIFLDIAC FFKGQSIEYI KKVLDGCGFE TTIGIEILFE RSLIRKEHGT LQMHDLVQLM GQNIVYQECP HDPGKRSRLW LFEDVQDILC EDMATNAVRA IVLDLPAPKV RAVNPEEISI CPDAFGNMKM LRMLIFIEVH ISLQGPVYLP NNLRWLEWPN ALFLECGFGS KKLVGLDIQK SHIRHLTQTQ CKSLVSVPDL SSFPNLESLN LDGCKSLVEV QLECHKNLKF LSLQFCSNLS KFPHTLKATS LQALNLFGCS KLEKFSNIPE KMEHLEELDL GWTAIKELPA SIENLVSVKI IILRKCKRLA MLPSSVYKLQ NLEHLNLGGC SNFVKFPENL EDSSNFNGNL GFRNLYRLDL YDCNLSEVKF IENSFSFPKL ERLDLSGNKL THLLTSIYTY DLFIPKCKQL RKIHRLLPMC MCYEHMV // ID A0A059BN97_EUCGR Unreviewed; 1092 AA. AC A0A059BN97; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 28-FEB-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KCW67573.1}; DE Flags: Fragment; GN ORFNames=EUGRSUZ_F01325 {ECO:0000313|EMBL:KCW67573.1}; OS Eucalyptus grandis (Flooded gum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; OC Eucalypteae; Eucalyptus. OX NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW67573.1, ECO:0000313|Proteomes:UP000030711}; RN [1] {ECO:0000313|Proteomes:UP000030711} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24919147; DOI=10.1038/nature13308; RA Myburg A.A., Grattapaglia D., Tuskan G.A., Hellsten U., Hayes R.D., RA Grimwood J., Jenkins J., Lindquist E., Tice H., Bauer D., RA Goodstein D.M., Dubchak I., Poliakov A., Mizrachi E., Kullan A.R., RA Hussey S.G., Pinard D., van der Merwe K., Singh P., van Jaarsveld I., RA Silva-Junior O.B., Togawa R.C., Pappas M.R., Faria D.A., RA Sansaloni C.P., Petroli C.D., Yang X., Ranjan P., Tschaplinski T.J., RA Ye C.Y., Li T., Sterck L., Vanneste K., Murat F., Soler M., RA Clemente H.S., Saidi N., Cassan-Wang H., Dunand C., Hefer C.A., RA Bornberg-Bauer E., Kersting A.R., Vining K., Amarasinghe V., Ranik M., RA Naithani S., Elser J., Boyd A.E., Liston A., Spatafora J.W., RA Dharmwardhana P., Raja R., Sullivan C., Romanel E., Alves-Ferreira M., RA Kulheim C., Foley W., Carocha V., Paiva J., Kudrna D., RA Brommonschenkel S.H., Pasquali G., Byrne M., Rigault P., Tibbits J., RA Spokevicius A., Jones R.C., Steane D.A., Vaillancourt R.E., RA Potts B.M., Joubert F., Barry K., Pappas G.J., Strauss S.H., RA Jaiswal P., Grima-Pettenati J., Salse J., Van de Peer Y., RA Rokhsar D.S., Schmutz J.; RT "The genome of Eucalyptus grandis."; RL Nature 509:356-362(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK198758; KCW67573.1; -; Genomic_DNA. DR Proteomes; UP000030711; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 4. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030711}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030711}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 14 157 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1092 1092 {ECO:0000313|EMBL:KCW67573.1}. SQ SEQUENCE 1092 AA; 124692 MW; BBB14A49EA68BC35 CRC64; MASSPMPKDE QSQYKYDVFL SFRGEDIRKN FVDHLHDHLW RRGIMAFRDD HHHHLQRGKC IKPEILRAIE QSRYVLVIFS ENYASSTWCL EEVAKVVECK DINEGSVIPI FYKFDPSDIR KLRGNFGRGL AQTEETYTGN RGDMKRWKDA LSKVAGLAGR ELKDGYETQF IRQIIGEIKD KLGPRLSYVV GNLVGMHSRV ANVVEYLCLD KSDVCGIGIW GMGGIGKTTI ARAVFDKIHG QFDDGCCFLA NVREISKKNG LIYLQNQFLG DILQEDNLTI KDDHRGANMI KERLQHKKVL IVLDDVDEKE QLEKLVGGFD WFGHGSRIII TTRDEHLLLQ YGVNSIYKGE ELSFGEALQL LCLKVFKSNH PPAEFTELVK QVIGYADGLP LALDVLGSFL ACRSLMQWKS ALARLKECPE GKIFDRLRLS YDGLRQKEKE IFLDIACFFK GKEKPYITEV LDNCDLYANI GIEVLVEKSL IQIVGNRLWM HDLLQEMAWE IVRRESPEEP GERSRVWLFE DVCHILSKNS GTGKVKAIVL RSGDHRIVCL NGESFTNMTN LRLLDVRTIN LSSGFKHLSN ELRLLRWDNY NLKSFPPSFL PKNLVELHMQ DSLLCSLWRG KKVLEKLKVI NLNGSKLFVK PPNFKNVPNL ERLILKGCKA LSQVHPSIGY LERLSLLDLG DCENLTGLPD TIGNLKALKV LNLSRCSNLE ELPKSIGGLE CLEELDISES AITHLPSSLA FLQNLKKLRF HVSKRRPRNF WTLMHTLRTT LNSRCPRLQS FLGLSSLTEL DLSGCSLLEG EIPNDFDCLP SLRSLDLAEN FFTTITTSIK HISSLHFLII NHCKKLEVLP RLPESTMVVV AENCPKLKRI SNPFIICTIP DSGFYFLNCS GLLPQDLDLT LQQKYSLSLF HYIFCCSIRL ILGTYVVSPC LQCEIPEWFS YQAIGPLLSI DMPPNWHDNS WRGFALCASF GRINRSPCRD LENDHFIFCG FHADGNQLGP VFKFPIRFVN SGCLWLGHVL YSQFPCDTNW ETMSLIVTSF TITDPELKVE KCGVHLIYEQ SPTEFDDLLV KWSSSLPRDW DRSYHEVQPP RK // ID A0A059BP93_EUCGR Unreviewed; 889 AA. AC A0A059BP93; DT 09-JUL-2014, integrated into UniProtKB/TrEMBL. DT 09-JUL-2014, sequence version 1. DT 28-FEB-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KCW67535.1}; GN ORFNames=EUGRSUZ_F01276 {ECO:0000313|EMBL:KCW67535.1}; OS Eucalyptus grandis (Flooded gum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; OC Eucalypteae; Eucalyptus. OX NCBI_TaxID=71139 {ECO:0000313|EMBL:KCW67535.1, ECO:0000313|Proteomes:UP000030711}; RN [1] {ECO:0000313|Proteomes:UP000030711} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24919147; DOI=10.1038/nature13308; RA Myburg A.A., Grattapaglia D., Tuskan G.A., Hellsten U., Hayes R.D., RA Grimwood J., Jenkins J., Lindquist E., Tice H., Bauer D., RA Goodstein D.M., Dubchak I., Poliakov A., Mizrachi E., Kullan A.R., RA Hussey S.G., Pinard D., van der Merwe K., Singh P., van Jaarsveld I., RA Silva-Junior O.B., Togawa R.C., Pappas M.R., Faria D.A., RA Sansaloni C.P., Petroli C.D., Yang X., Ranjan P., Tschaplinski T.J., RA Ye C.Y., Li T., Sterck L., Vanneste K., Murat F., Soler M., RA Clemente H.S., Saidi N., Cassan-Wang H., Dunand C., Hefer C.A., RA Bornberg-Bauer E., Kersting A.R., Vining K., Amarasinghe V., Ranik M., RA Naithani S., Elser J., Boyd A.E., Liston A., Spatafora J.W., RA Dharmwardhana P., Raja R., Sullivan C., Romanel E., Alves-Ferreira M., RA Kulheim C., Foley W., Carocha V., Paiva J., Kudrna D., RA Brommonschenkel S.H., Pasquali G., Byrne M., Rigault P., Tibbits J., RA Spokevicius A., Jones R.C., Steane D.A., Vaillancourt R.E., RA Potts B.M., Joubert F., Barry K., Pappas G.J., Strauss S.H., RA Jaiswal P., Grima-Pettenati J., Salse J., Van de Peer Y., RA Rokhsar D.S., Schmutz J.; RT "The genome of Eucalyptus grandis."; RL Nature 509:356-362(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK198758; KCW67535.1; -; Genomic_DNA. DR Proteomes; UP000030711; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 4. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030711}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030711}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 14 157 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 889 AA; 101092 MW; B0E2D0D593EA4B2B CRC64; MASFPRPKNK KSQYKYDVFP SFRGEDIRKN FVDHLHDHLL RRGIMAFRDD HHLDLPRGKC IKPEILGAIE QSRLVLVIFS KNYTSSTWCL EEVAKAVECK DINEGSVIPI FYEVDPSDIR KLRANFGTGF TKIEEAYSGD KRDIKKWKDA VSEVVGLAGI ELKDGYETKF IQQIIREVEN KLGPRLPYVV GNHVGMHSRV ANVVECLCLD KSDVHSIGMW GMGGIGKTTI ARVVHDKIRG QFNDGCCFLA NVREISKKNG LVYLQNQFLG DILHNDNLRI RDDHRGVNMI KERLQHKKVL IILDDVDEKE QLEKLVGGFD WFGSGSRIII TTRDEHLLLQ YGVNSIYKVE ELSFGEALQL FCLKAFRSNH PPIEFNELVE QVIRYANGLP LALDVLGSFL ACRSSMQWKS ALARLKECPE EKIFDRLRIS YDGLQQKEKE IFLDIACFFK GNEKPYVIEV LDNCGFYADI GIEVLVDKSL IQIVDNKLWM HDLLQEMAWE IVRRESPEEP GERSRVWLFD DVCHILSKNS MRVLEKLKVI NLSGSILFVE TPNFIYVPNL ERLILKGCKA FSQVHSSIGN LERLNLLDLG DCENLTRLPD SVGNLKSLRV LNLSGCSNLE ELPVSIGGLE CLEELDISES AITHLPSSLT FLQNLKKLCF QVSKRRPQNF WRTLMCPLRR ALNSRHPRLP SFLGLSSLTE LDLSGCSLLE GEIPSDIDYL PSLRSLDLAK NNFTTITASI EHISGLEFLI LNHCKNLEVL PRLPESIIVV AAEKCLRLER ISNPFIICTV PDSGVCFLNC SSLLPQDLDL TLQQKYSLSL LRYIICCSMR MISGNYVVCP CLQCEIPEWL SYQAVGPLLS IEMPPNWHDN SWRGFAICAS FKQINCSSC // ID A0A067RBH7_ZOONE Unreviewed; 527 AA. AC A0A067RBH7; DT 03-SEP-2014, integrated into UniProtKB/TrEMBL. DT 03-SEP-2014, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KDR17154.1}; GN ORFNames=L798_08415 {ECO:0000313|EMBL:KDR17154.1}; OS Zootermopsis nevadensis (Dampwood termite). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; OC Termitoidae; Termopsidae; Zootermopsis. OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR17154.1, ECO:0000313|Proteomes:UP000027135}; RN [1] {ECO:0000313|EMBL:KDR17154.1, ECO:0000313|Proteomes:UP000027135} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR17154.1}; RX PubMed=24845553; DOI=10.1038/ncomms4636; RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z., RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W., RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M., RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T., RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., RA Zhou J., Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., RA Liberles D.A., Roe R.M., Vargo E.L., Vilcinskas A., Wang J., RA Bornberg-Bauer E., Korb J., Zhang G., Liebig J.; RT "Molecular traces of alternative social organization in a termite RT genome."; RL Nat. Commun. 5:3636-3636(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK852751; KDR17154.1; -; Genomic_DNA. DR EnsemblMetazoa; KDR17154; KDR17154; L798_08415. DR OMA; REITCEG; -. DR Proteomes; UP000027135; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000027135}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KDR17154.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000027135}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 33 {ECO:0000256|SAM:SignalP}. FT CHAIN 34 527 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001648088. FT TRANSMEM 269 291 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 370 392 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 71 139 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 252 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 311 448 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 527 AA; 60734 MW; 99696F55FB981099 CRC64; MEVRRNMNGC ILQLSHVLFT LVLLILTDHV MYAENEKGFC EMNLFEKNKT SLEFTKEVNT FDYVVIERYK SLSCCAKGYK TIKWYKDGNI ISAGNRNITF HELREQNQTL ISIRVTDLDN GTYTCKVSDG INEIQRKIQL KVMPEVTYMG PALLTYVTES YQYAQIGETA RFFCEGFIGH GKKHNSQVAW VMDKTNTFPD TSDKRRYTKS VARAEDLIIG EYLIFKTVTK EDFGTYKCTI SNGGSPKVFN VTLIEGDNPT MKIRTSYKAT VVIISVFTCS VVLLIGVYMR WHLELHLFWK DHFGKLEDDN KEYDVFVCYD QTDTEFALGV LVHTLEKCYH YRCFVYERDS VAGDWIPEIY TMKIRSSRRF LMVLSPALAI NSWCTYALYV AIEAMLNLHS KIICVVLQDI PWKNFKQTNG TSDHTLQHVL RVVKKVQWQP AVIERPHPLL KMCTSQKHKL HTSNLSDSNC GNSEESLSSA VLDGSKENII NSVKHTDTRI HPGSKRFWTS LRINLPPKRP TNIKRVS // ID A0A072UMY5_MEDTR Unreviewed; 1165 AA. AC A0A072UMY5; DT 01-OCT-2014, integrated into UniProtKB/TrEMBL. DT 01-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 20. DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:KEH30741.1}; GN Name=25492928 {ECO:0000313|EnsemblPlants:KEH30741}; GN OrderedLocusNames=MTR_4g080777 {ECO:0000313|EMBL:KEH30741.1}; OS Medicago truncatula (Barrel medic) (Medicago tribuloides). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; OC Trifolieae; Medicago. OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH30741.1, ECO:0000313|Proteomes:UP000002051}; RN [1] {ECO:0000313|EMBL:KEH30741.1, ECO:0000313|EnsemblPlants:KEH30741, ECO:0000313|Proteomes:UP000002051} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A17 {ECO:0000313|EMBL:KEH30741.1}, and RC cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH30741, RC ECO:0000313|Proteomes:UP000002051}; RX PubMed=22089132; DOI=10.1038/nature10625; RA Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B., RA Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H., RA Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M., RA Cheung F., De Mita S., Krishnakumar V., Gundlach H., Zhou S., RA Mudge J., Bharti A.K., Murray J.D., Naoumkina M.A., Rosen B., RA Silverstein K.A.T., Tang H., Rombauts S., Zhao P.X., Zhou P., RA Barbe V., Bardou P., Bechner M., Bellec A., Berger A., Berges H., RA Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R., RA Deshpande S., Dai X., Doyle J.J., Dudez A.-M., Farmer A.D., RA Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S., RA Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A., RA Humphray S.J., Jeong D.-H., Jing Y., Jocker A., Kenton S.M., RA Kim D.-J., Klee K., Lai H., Lang C., Lin S., Macmil S.L., RA Magdelenat G., Matthews L., McCorrison J., Monaghan E.L., Mun J.-H., RA Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R., RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., RA Sallet E., Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., RA Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., RA Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B., Wang K., RA Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D., RA White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F., RA Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D., RA Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.; RT "The Medicago genome provides insight into the evolution of rhizobial RT symbioses."; RL Nature 480:520-524(2011). RN [2] {ECO:0000313|EMBL:KEH30741.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A17 {ECO:0000313|EMBL:KEH30741.1}; RX PubMed=24767513; DOI=10.1186/1471-2164-15-312; RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S., RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F., RA Schwartz D.C., Town C.D.; RT "An improved genome release (version Mt4.0) for the model legume RT Medicago truncatula."; RL BMC Genomics 15:312-312(2014). RN [3] {ECO:0000313|EnsemblPlants:KEH30741} RP IDENTIFICATION. RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH30741}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM001220; KEH30741.1; -; Genomic_DNA. DR RefSeq; XP_013456710.1; XM_013601256.1. DR EnsemblPlants; KEH30741; KEH30741; MTR_4g080777. DR GeneID; 25492928; -. DR Gramene; KEH30741; KEH30741; MTR_4g080777. DR KEGG; mtr:MTR_4g080777; -. DR Proteomes; UP000002051; Chromosome 4. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002051}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000002051}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 100 241 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1165 AA; 133201 MW; A194BDF06D5314D2 CRC64; MSYSSSYCHC TVDAADEITK FETDSWSATD TTPTHVNYVI FSDYDWDVDV SVSMSYMCHF QLHSNGAKYI ILSKLVLAFT IAMTMACNSI RSISSPKMKW KYDVFVSFRG GDTRNNFTDH LFGTLHKKGI VTFRDDTKLK KGENISSELL QAIEGSRILI VIFSRNYASS TWCLKELVKI AECIEVTGQI VLPIFYDVDP SEVRKQSGDY EKAFRDHEER FKGNLEKVQR WRGALAQVAE LSGWDVRDQP QYAEIGKIIK EVTCLLSHKS STLPNDIVGM HSRVEELEKL LIMDSDDDVR VVGICGMGGI GKTTLATALY DRISNQFDAC CFIEDVSKIY GDHGPIGVQK QLLCQTLNEE NLQICNLFMA SNLIRTRLCQ IKSLIVLDNV DQVEQLDKLA MTREWLGTGS RIIIISRDVH ILREHGVDEV YKVRLLDHNN ALQLFCRKAF KSDDIMSGYI YLTDDALTYA NGLPLAIKVL GSFLYGRDVS EWRSALARLR ENPRTDIMDV LRISFDGLED TEKDIFLDIA CFFYKKSETY VNKVLDFRGF HPEIGLRVLV DKSFITCENG RIFMHDLFKE LGKSIVREKS PKEPRKWNRM WDYKDVHNVI SENMATSNLE AIVLRRYPEN IEEIQGMTTL RTEALAQMSR LKLLMLWNLN FSGSLNFLSS HLGYLCWDKY PFTCLPSSFQ PDKLVELVLP RSNIRQLWEG TKCLHNLTHI DLSHSENLIM MPDFLEIPNL ELLDLEGCIK LQQIDPSIGI LRRLSKLNLK NCRNLVSIPS NIFGLSSLKH LNLSGCPNLL NNKMLERQRQ NEHLEMLDIK ECTTQYQPTS FIYKVLKPHF PFSFFRKRED SVGLLLPSLS CLSCLQYLDL SFCNLFQIPN AIGRLHCLEI LNVGGNNFVT LPSSIKELSK LRQLNLEHCK QLKYLPELSS NTVLPVGKTF FGRYVAGLYI FDCPGLIEME CCYRMAFSWM IQLLKVHMQS YLPMGQINFV IPKTQIPTWF NKQNVGSSIS IDPSPVMHDN LIGVACCLTF VARDGPTNLS ETGQYQDNPT NLGAGWSPYI GFGFKSKHCG RFPIIPIHLG KDLVTVDLDH LLLILFTREE FINYYMNYIT KGLHDISGIE LTAVVEQPLG LHLEVKNCGY HWIFKEDLEH LNPQMMYSGN SSVQP // ID A0A078F686_BRANA Unreviewed; 955 AA. AC A0A078F686; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 19. DE SubName: Full=BnaC08g11460D protein {ECO:0000313|EMBL:CDY08916.1}; GN Name=BnaC08g11460D {ECO:0000313|EMBL:CDY08916.1}; GN ORFNames=GSBRNA2T00000936001 {ECO:0000313|EMBL:CDY08916.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY08916.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY08916.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK031990; CDY08916.1; -; Genomic_DNA. DR EnsemblPlants; CDY08916; CDY08916; GSBRNA2T00000936001. DR Gramene; CDY08916; CDY08916; GSBRNA2T00000936001. DR OMA; GINDETC; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 3. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 59 197 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 955 AA; 107203 MW; 13CDC6610BCD9916 CRC64; MASSTNDFIR KSRSHQENGS IASSEILFII ESESHQENET MASSSSTLLD PQSSLSHSCL HHVFPSFHGA DVRTNFLSHI VKEFKSKAID LFIDNDIVRS KSIGPELIEA IRGSRIAIVF LSKNYSSSTW CLNELVEIMH CREEFGKTVM SIFYEVDPTD VKKQTGYFGK VFEKTCEGKT EEEIRRWKHA LAEVAQIAGF HSSNCRTVEH LLNFFRKNEA EMIEDIATDV SNKLNLSAPS NDFDGLVGME SRMAELMPLM LELDSHEVLK IGIWGPPGIG KTTIARYIFN RYSRYVDLSV FMDNIKTKYA KTACSDDYSV KLDLQKQFMS QLTNEKDIKN FSHLGIAKDR LKDKSVLVIL DDVDRPVQVE AVAKENSWFG HESLIIVITQ DLKVLKASGI NHIHKVNLPS YDEALQIFCM HAFGQRYSKD GFIELACEVV SLVENLPLGL RVMGSYFQGM SEQDWTEALP RLRTHIGRDG EIASILISYD SLCDEDKHLA LHIACFFNGE SVDIVECCLA KRFLDVTQGL RVLAEKSIIS MKWGKIKMAE LLVQLGRKLV REQSVSEPGK RQFLNDAIGI EEVLSDYKAD NSSVIGINDE TCGDIECTSE RAFERLSNLQ FLRIHGDGIN PRSMNHISQK LRVLCWSSFQ MTCFPSSFNP KFLVKLEMPN SKLEKLWKKT QLLSNLKRMD LSYSRRLKEL PDLSTATNLY DLDLSYCSSL VKLPSSIGNA INLNKLDLSH CSSFVELPFS IGNAINLQKL NLSYCSSLME LPSSIENAIN LRKLNLSYCS SLVELPSCIG NAAKLEELDI SHCSSLVEIP SSIGNAINLQ KLKISHCSSL VELNQLALGI STKFKACILC ADSDGVNFPP LSQASVCCSI MSGGNARTAC YKKVGRVSSG HLYTFRVEIE TEEVTSPELV FEFEIQFGNV NSETWEINEC GILQILEVPH DDSHY // ID A0A078F692_BRANA Unreviewed; 1625 AA. AC A0A078F692; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 19. DE SubName: Full=BnaC08g11510D protein {ECO:0000313|EMBL:CDY08921.1}; GN Name=BnaC08g11510D {ECO:0000313|EMBL:CDY08921.1}; GN ORFNames=GSBRNA2T00000941001 {ECO:0000313|EMBL:CDY08921.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY08921.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY08921.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK031990; CDY08921.1; -; Genomic_DNA. DR EnsemblPlants; CDY08921; CDY08921; GSBRNA2T00000941001. DR Gramene; CDY08921; CDY08921; GSBRNA2T00000941001. DR OMA; SHIAKEF; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 2. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 2. DR Pfam; PF01582; TIR; 2. DR SMART; SM00382; AAA; 2. DR SMART; SM00255; TIR; 2. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 2. DR SUPFAM; SSF52540; SSF52540; 2. DR PROSITE; PS50104; TIR; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 7 28 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 57 201 TIR. {ECO:0000259|PROSITE:PS50104}. FT DOMAIN 1076 1153 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1625 AA; 182509 MW; 93112C8AD82A4F65 CRC64; MDSYFSLTNL VAAAICFYAL LGTIFFNMKS RSHQEDKTVA SSSLTVLPPP SSLPPNWKHQ VFPNFHGVDV LENFLSHIVK EFRSKGINLF IDSDIERSKS IGPELTEAIR GSRIAIVLLS KKYASSTWCL NELMEIIKCS EELGQTVMSI FYQVDPTDVK KQTGKTKEEI RRWQHALTEV AQIAGYHLSN WFNEAQMIED IATDVSNKLN FSAPCSDFKG LVGMEYHMVN MGLLLQLKSD KVRKIGILGP PGIGKTTFVR YIFNRYSSEF ELSVFMDNIK RRYATTACSD DYNVKLDLQK QFMSQLTNVT DIKNFSHLGI AKDRLKDKKV LVVLDDVDRL VQVEALAKET SWFGPGTRII ITTQDQRVLK ASGINHIHKV MLPSYDEALQ MFCMYAYNLK YPKDSFKELS CEVVSLVGRL PLGLKVMGSY FRGTCEQDLA EALPKLRTHL DRDGEIVSVL NLLFCEKADI VEGCLAKCFL DVRNELRVLA EKSIISTNMD WGTIEMAKLL VELGRKIVRE QSVDEPGKRQ FLTDAVDVCE VLSDDRAESS GVIGITVKTY EDIECTSERA FERLYNLQFL RILGKGVNPR SMNHISQKLR VLIWPNSEIT CFLSNFNPKF LVKLEMMNSK LKKLWEETKP LNNLKWMNLS RSRRLEELPD LSTATNLYDL DLSYCSSLVK LPSSSGNTIN LQSLDLSFCS KLVEIPPSIG NAIPTSITTI TSLTSLDLSG CSSMVKLSDN IETFTEPNHI NLSGCSSLVE LPSSIGNAIN LQKLNLSHCS SLVELPFSIG SAINLQKLDL SRCSSLVKLP SSIGNAINFH KLNLDRLLKC SKLEVLRSTL LRELDPWIWR ISRLRTLVLN GMKKLVSLPP LPEDCESLER LDCSFDNPDI CLNFVNCFKL NQEARDLISL TPTNGYAVFP GTEVPQCFTY RSSGSSLTVK LIQKSLGIST KFKACILSAD LDGNNYPHWS QASVCCSIMS RGNALTACYR SLGRVIPGHL YTFEVEVETG ELTSNELTKV SSCAFHREGA AVGVVNGRHI CSSQLSLYRK VSPVSSVASS SSLTLLAPPS SLPHNWKHHV FPSFHGADVR TNFLSHIAKE FKSKGINLFI DNNIERSKSI GPELTEAIKG SRIVIVLLSK NYASSTWCLN ELRKNKEGDT KMETCFDGSG SNCRKNESEM IEDIATDVSN KLNLSAPSSD FDGLVGMESQ MTELEPLLQL DSDEVRKIGI WGPPGIGKTT IARYLFNRHS KDFQLNVFID NIKRKYETTA CFDDYSAKLY LQEQLISKLT NVTDIKNFSH LGIAKERLED KKVLVVLDDV DRLVQVEAMA KETSWFGPGS QIIITTQDQN VLKASGINHI HRVNLPSYHN ALEIFCMYAF GQKDPKDGFS DLPYKIVSLV GKLPLGLKVM GSYFRGMSEQ DWIEAHLDRD GEIASILKFS YDSLCDEDKR LFLHIASFFN GEKFDIVEGC LAKCVSDVRH GLRVLTEKSL ISKFLGTIEM DKLLVELARK IVREQSVNEP GKRQFLTDAI GVGEVLSDDR ADSSSVVGFT VGTFDEITWT SERAFERLSN LQFLRILGKG VNPRSMNHMS QKLRVLIWHN FKMTCFPTSF NPKFRVKLKM PYSKA // ID A0A078G7Z6_BRANA Unreviewed; 896 AA. AC A0A078G7Z6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 18. DE SubName: Full=BnaA01g33780D protein {ECO:0000313|EMBL:CDY21147.1}; GN Name=BnaA01g33780D {ECO:0000313|EMBL:CDY21147.1}; GN ORFNames=GSBRNA2T00015334001 {ECO:0000313|EMBL:CDY21147.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY21147.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY21147.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032116; CDY21147.1; -; Genomic_DNA. DR EnsemblPlants; CDY21147; CDY21147; GSBRNA2T00015334001. DR Gramene; CDY21147; CDY21147; GSBRNA2T00015334001. DR OMA; ATEFTHI; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 54 192 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 896 AA; 100785 MW; A500FCDE6B19A639 CRC64; MDLYLILVII ATLLCSRIFS FVYGKFRVQE NKIIAYSSSS PSPPSPKSTL PRNCIHDVFP SFHGKDVRKS FLSHLLKECG IKGINLFIDN EITRGEFIGP ELKKAIQGSR IAIVLLSKRY ASSSWCLDEL VEIMKCKEDL GQTVMPVFCE VDPTDVKKQA GEFGKVFKET CKGKTNEVTR KWSEALAKVA TLAGYHSKNW DNDAKMIEDI AIDVANKLFN SSPSRDFDEL IGMEAHMEKI SRVLRTDLDE VRMIGIWGPA GIGKTTIARC LFNQLSHTFQ YSVFLMNVKA MCTPPVCSDD YNVKLLLQQK FLSQLLNQKE DLKISHLGVA QERLNDKKVL VVLDNVDRLV QLEAMAKKTG WFGNGSRIII TTQDRKILKA HGITDIYKVD FPSDCEAIQM FCMYAFGQKS PEDGFENLVW EVTRLVGKLP LGLRVMGSHF REMSKQEWEN ELPELWRCLD GEIESILMFG YNALSQENKD LFLHIACFFN AEWKEKVAEH LSTRFSNMRK RLNVLAEKSL ISLESGVVSM HDLLVQLGRD IVRKQSSEPG QRRFLVDKRE NCEVLADDAA GSGNVIGITF FYRGEINVSE RAFEGMSNLQ FLRFRVERDG GGDALHLFGG ASYLSRKLRL LDWSKFPMTC LHCIPNPELL VELIMVCSKL EKLWEGTKPL TNLKWVNLSD SKNLKDVSSL STATSLEELN LSGCSSLLDL SGCSSLVELP SSIGNAIHLK KLHLSGCSSL LPSSLGNAIG NLEELDFSDC SSLVRVPSSI GNATNLQELD FSRCSSLVEL PASIGNLHKL ETLILEECRK LEALPVNINF KSLMTLDLTD CSLMKSFPEI STDIVYMYLA GTAIKEVPSS ISLWPRLHVL HMSYNENLKE FGHEQHRNTR DSSLDQ // ID A0A078GAP9_BRANA Unreviewed; 1195 AA. AC A0A078GAP9; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=BnaC03g61670D protein {ECO:0000313|EMBL:CDY22454.1}; GN Name=BnaC03g61670D {ECO:0000313|EMBL:CDY22454.1}; GN ORFNames=GSBRNA2T00019002001 {ECO:0000313|EMBL:CDY22454.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY22454.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY22454.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032131; CDY22454.1; -; Genomic_DNA. DR EnsemblPlants; CDY22454; CDY22454; GSBRNA2T00019002001. DR Gramene; CDY22454; CDY22454; GSBRNA2T00019002001. DR OMA; EISECAV; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 209 379 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1195 AA; 135087 MW; 27EDD9E6CC7AB32C CRC64; MEKLESLPPL PDSLWALDAE NGESLERLGS SFRNPDINLS FLNYFKLNQE EKDLIIQTPS NECAVFPGEE MPQCFTYRSS GSSLTVKLNQ TPLGTSTKFK ACIVCAGEDE KGFTEWERAS VCCSITTPGG IALSSCLKTI EQFLPGHLYT FEFEVETDEV TSTELVFEFE VDYADLIKKG KTLEIKERGI MLVNMIESFG DDNSCILFNW LDVFVSFEAS NTISIVMNLK QTLKIEQYKH HKLHVHTVMI VERVRTNFLS HVLKELRSKG IDSFIDNDIE RSKLIGPELV EAIRGSRIAI VLLSRNYASS TWCLNELVEI MKCREEFGQT VMPLFYELDP TDVKKQTGDF GKVLGKTCRG KEKEDIQRWK RALTEVAQIA GFHSAKGENE AELIEYIATD VSNKLNLSAP CSDFDGLVGM ESRMAEMRQV LQLDSDEVRK IGILGPPGIG KTTIARSIFN RHSQDFQLSV FMDNIKRKYV IMACSDDYSV KLDFQKQFMS QLTNETGIKI PHLGVAKDRL KDKKVLVVLD DVDQLVQLEA MAKETSWFGP GSRIIITTQD ENVLKASGID HIHRVNLPSD DEALQMFCMY AFGQKYPMSG FNELAYEVTS LVGKLPLGLR VMGSHFRGMS EQDWREALPR LRTHLDRNGE IAGILKFSYD ALNDEDKRLF LHIACFFSGE PIDMVERCLE KCFQDVRQGL RVLSEKSLIY SKSGLIMMST LLFQLGRQIV QKESISEPGK RQFLNDAIDI GEVLSDDKAG NSNVIGIDLE WNKDITWTSE RAFERLSNLQ FIRILGKGVN PLKFLVNLFV RNSNLEKLWE ENKPLKNIKW MDLALSRRLK ELPNLSTAIN LYYLDLSYCS SLVKLPSSIG NATNLEKLSL NYCSSLVKLP SSIGNAINLK TLSLKGCSSM VKLPSSIWNI VNLEELNLEN CSNLVELPSL LRSEIEKCTK SDCSRGSGKI INRLPIIAGL LPNPQFEKNN TIKYSESSTN IEELDPWIGR ILRLRRLVLS GMRKLVSLPQ LPDSLLELDA ENCESLERLH CSFPNQDIRL NFANCFKLNQ EARDLIIQMP TNKYAVFPTE KVPICFSYRS SGSSLTVKLN RLPVGKSTKF KACILCAYDD ENNFGLWETA SVFCTITFGG NASIACNKRV ERVLPGNLCT FEVEVETEEV PFEDFESSDI ELVREDDGNK RLPLL // ID A0A078GWS4_BRANA Unreviewed; 925 AA. AC A0A078GWS4; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=BnaC01g40270D protein {ECO:0000313|EMBL:CDY29981.1}; GN Name=BnaC01g40270D {ECO:0000313|EMBL:CDY29981.1}; GN ORFNames=GSBRNA2T00044502001 {ECO:0000313|EMBL:CDY29981.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY29981.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY29981.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032247; CDY29981.1; -; Genomic_DNA. DR EnsemblPlants; CDY29981; CDY29981; GSBRNA2T00044502001. DR Gramene; CDY29981; CDY29981; GSBRNA2T00044502001. DR OMA; NREAIQM; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 45 183 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 872 895 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 925 AA; 103623 MW; 5259C75EE34E1F6D CRC64; MDLYLLLVIV ATLLCSRIFS FVYAKFRVQE SSSSSSPPSP QSSLPIHDVF PSFHGADVRK SFLSHLLKEC GSKGINLFID NEITRGEFIG PELKKAIQGS RIAIVLLSKR YASSSWCLDE LVEIMKCKED LGQTVMPVFY EVDPTDVKKQ TGDFGKVFKN TCKGKRDEVT RKWSQALSKV ATLAGYHSMN WDNEAKMIED VATEVAKRLF NSTPPRDLDE FIGMEAHMEK ISRVLRTDLD EVRMIGIWGP AGIGKTTIAR CLFHQLSHSF QYSVLMMNVK AMCTPPVCSD DYNVKLHLQQ KLLSQLTSQK EEDFKISHLG VARERLNDKK VLVVLDNVDR LVQLQAMAKE TWFGHGSRII VTTQDRKILN AHRITDIYKV DFPSDCEAIQ MFCMYAFGQK SPEDGFDRLV SEVTRLVGKL PLGLRVMGSH FRGMSKQEWE NELPELWRCL DGEIESILMF GYNALSYENK DLFHHIACFF NNQWKEKVVE HLSTRFSNMR QRLNVLADKS LISLESEYVI MHDLLVQLGR YIVRKQSSEP GQRRFLVDER ETCEVLADDA AGSGNVIGIM FDGDEINVSE RAFEGMSNLQ FLRLGPKIGG DELHLFGGQS YLSRKLRLLE WRYFPMTCLD CIPNPELLVE LIMYRSKLEK LWEGTKPLTN LKWVNLAHSK NLKDVSSLST ATSLEELNLR GCSSLVELPS SIGNALKKLD LYECSSLVEL PASIGNAIHL EKLDLSGCSS LVELPSSIGN ATNLQFLSLI RCSTLVELPS SLGNAIGNLE ELDFSGCSSL VRVPSSIGNA TNLQRLDFSR CSSLVELPAS IGNATNLQRL DFSRCSSLVE LPASIGNATN LRHLEFSRCS SLVGVPSSIG NATNLESLKK ESSEEVNNNQ KRKREHNLSS STPGVEGGHN HGFAFCKKVT SLEGT // ID A0A078GXM2_BRANA Unreviewed; 974 AA. AC A0A078GXM2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 15. DE SubName: Full=BnaC01g40310D protein {ECO:0000313|EMBL:CDY29977.1}; GN Name=BnaC01g40310D {ECO:0000313|EMBL:CDY29977.1}; GN ORFNames=GSBRNA2T00044496001 {ECO:0000313|EMBL:CDY29977.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY29977.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY29977.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032247; CDY29977.1; -; Genomic_DNA. DR EnsemblPlants; CDY29977; CDY29977; GSBRNA2T00044496001. DR Gramene; CDY29977; CDY29977; GSBRNA2T00044496001. DR OMA; RCIINTE; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 56 194 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 974 AA; 110146 MW; C17043959ED814A4 CRC64; MDLYLLLVTV ASTMFTLLCS KIFSIVYAKF IVQENKIIAY SSSSPPSPKS SLPRNCIHDV FPSFHGADVR KSFLSHFLKE LGSKGINLFT DKEIHRGEFI GPELKKAIQG SRIAIVLLSK RYASSSWCLD ELVEIMKCKE ELDQTVMPIF YEVDPSDVKK QAGEFWKVFK ETCKGKTNEV IGKWSQALAK VATLAGYHSM NWDNDVKMIE DVATEVANKL FNSTPSRDFD EFIGMEAHMN KISPVLRTDL DEVRMIGIWG PAGIGKTTIA RCLFNQLSHS FQHSVFLMNV KAMYTPPVCS DDYNVKLHLQ QKLLSQLINE KEEDFKISHL GVARERLNDK KVLVVLDNVD RLVQLQAMAK ETGWFDVLYV CFWSKKVVEH LSKRFTDVRQ RLNVLAEKSV ISLESERVSM HDLLVQLGRD IVRKQSTEPG QRQFLVDNRE ICEVLADDAA GSRSVIGILF RGDEIYMSER AFEGMSNLQF LRLNVGPDGG GEAFHLFGGP SYLSRKLRLL DWSYFPMTCL HCIPNPELFV ELIMYGSKLE KLWDGTKPLR NLKWVDLSDS KNLKDVSSLS TATSLQELNL TRCSSLVELP SSIGNAIHLK KLDLSGCSSL VELPSSIGNA TNLQFLSLHR CSSIVELPSS IGNAIGNLED LDFSDCSSLV GVPSSIGNAT NLKRLYFRRC SSLVELPASI GDLHKLHSLI LRECRKLEVL PVNINLKSLT TLELTDCSLM QCFPEISTNI ESMYLTGTAI KQVPSSIRSW PRLDELHLSY SENLKESVHE QHRNTRDFSL DQKNLSSSST CTRRMQEAFS LERLDFSFLN QKIDLNFAKC FKLNKEARDV IIQTSTNYKV TILPGKEMPN YFNYQANGGS LVMKLNERTS SSSMTCKACI LLVSKDEVEA AIGRMVNVIH GIKQNSLDVP CNPSYHTLFR PLTEHLYIFE FEADVTSDEL CFEFKVDRDE WMIKECGVHY LNTS // ID A0A078H9A6_BRANA Unreviewed; 715 AA. AC A0A078H9A6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 14. DE SubName: Full=BnaA01g24490D protein {ECO:0000313|EMBL:CDY34232.1}; GN Name=BnaA01g24490D {ECO:0000313|EMBL:CDY34232.1}; GN ORFNames=GSBRNA2T00056240001 {ECO:0000313|EMBL:CDY34232.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY34232.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY34232.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032331; CDY34232.1; -; Genomic_DNA. DR EnsemblPlants; CDY34232; CDY34232; GSBRNA2T00056240001. DR Gramene; CDY34232; CDY34232; GSBRNA2T00056240001. DR OMA; GCDESII; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 2. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF01582; TIR; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 19 101 TIR. {ECO:0000259|SMART:SM00255}. SQ SEQUENCE 715 AA; 80032 MW; 6DF172696669801F CRC64; MASSLTLLDP TYSFPHSWKH HVFPSFHGED VRKNFLSHIL KEFRSKGIDL FIDNDIERKK LGQTVISLFY EVDPTDVKKQ TGKTKSDIKI WKQALVEVAK IAGYHSRNWF TDAEMIKDIA TDFLSSLKFS YDALNHEDKL LFLHIACFFN GEQVDIVEGC LAKCFLDVTQ GLRVLAEKSL ISMESRAIQM AELLVHLGRK NVLEQSVSDP GKRQFLNGTV DIGEVLSDDK AVRCSSVIGI DLKEEEDISC TSERSFERLT NLQFLRISGN GINPQSLNYI SQKLRVLVWS ECSFSDLEKL WDEIRLPDLS TATNLQELDL SFCSNLEKLP FSIGNAINLR KLDLKSFSSL VELPSSIGNA VNLKTFLIFN CTSLLEIPST IATITNLKSL RLSGCSNLVE LPFNIESVTN AMCIDLRCCS SLMKLPSSIG NAIYLQKLDL SHCSSLVKLP SSIGNILSLE ELKLSYCSSL VELPSSMKNL GRLSNLKLEK CLKLVILLAN INLESLGYLN LSDCSLLKSY PKISTDIQEL DPWTGRISSL QRLVLSGMKK LLNQKPLGIS TKFKACIICA DGNENGIADG DENGITDLVQ TVYCSITSEG NALTACHKRA GQVLKGHLYI FEVEVETEEM TSTELVFEFL VGYWHIYEER INSKTWEIKE CGVLQLQEVP LLSIRDVNED NEPSYTEIGD KPWNPSKTEK HQEKKSKITG ASSGI // ID A0A078HCE6_BRANA Unreviewed; 935 AA. AC A0A078HCE6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 18. DE SubName: Full=BnaC03g62030D protein {ECO:0000313|EMBL:CDY35457.1}; GN Name=BnaC03g62030D {ECO:0000313|EMBL:CDY35457.1}; GN ORFNames=GSBRNA2T00058467001 {ECO:0000313|EMBL:CDY35457.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY35457.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY35457.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032352; CDY35457.1; -; Genomic_DNA. DR EnsemblPlants; CDY35457; CDY35457; GSBRNA2T00058467001. DR Gramene; CDY35457; CDY35457; GSBRNA2T00058467001. DR OMA; SFENATH; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 3. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 48 103 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 888 922 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 935 AA; 105180 MW; DEBAC673D40A4A56 CRC64; MSSNGLPHTV YIYCADTLQY SFASHLSLAF HRKGIYASVN CNETLDKIEE ASGFVVVLSK NYLSSPSCLD KLVKALQCRR KHVQLVVPVF YGLSPSDVAV QEQESDDRIR DWISALQELR DLPGILSREE SSDCELVKEI VKDVYEKLFP TQQIGVNSRL LEIKQLLCKQ PWGIRHIGIW GMPGIGKTTL AKAFFDQLSG RYEASCFITH FDKAFHEKGL YRLWDEHFGK ILKDIPGVCS SITRPSLPGE KINKKRTLIV LDDVQNPLVA ESFLRGFHWF GPGSLIIVTS RDKRVFRLCQ ISQVYEVKRL NKNEALQLYS QCAFGKDIEE QKLMELPMEV IDYANGNPLA LSFYGEELKG KNLLEPNMIH DLLKSSYETL SDDEKDIFLD IACFFQGDEV DYVKQLLEGC GLFPHVGIDV LVEKCLVTIS ENRVEMHGII KDYGREINNK ETTWIKRGRR LWGASTIEFL LQDENLEAKG HPEATCKGAL VSISLDTTNF RFDLNPTAFE NMLNLRFLKI YSCNDKSISG VHLPKGLESL PNELRLLHWE NYPLQSLPQD FDPGHLVELN MPYSQLQTLW RGTKKLDMLK IARLSHSQQL TEIDDICKAQ NIELIDLQGC EKLQSFPATD QLQHLRVVNL SGCSEIRSFP ELSPNIEDIN LQGTAIRELQ ISIGDATNLK KLYLSGCSSL VQLPSSIGNA SNLQILDLSF CSSLLPSSLG IAANLKKLYL SGCSSLMQLP SSIGNAPNLQ ILDLSNCSSL IELPSSIGDA TKLKKLCLRG SSGLVQLPSS IGNAINLQEL DLEYCSSLVE IPSSFENATH LKKLYLTGCS SLSPVEEESV YGASASHSWT SDSSRLGEKG KQCFDEIEEE NEEEEGSSSQ EANEPVSLEE EERLRQELEE IEAKYREEMK EIERKREEAL METKKKLSLV KKTKS // ID A0A078HZM0_BRANA Unreviewed; 1678 AA. AC A0A078HZM0; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 20. DE SubName: Full=BnaA08g15560D protein {ECO:0000313|EMBL:CDY44050.1}; GN Name=BnaA08g15560D {ECO:0000313|EMBL:CDY44050.1}; GN ORFNames=GSBRNA2T00079465001 {ECO:0000313|EMBL:CDY44050.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY44050.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY44050.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032577; CDY44050.1; -; Genomic_DNA. DR EnsemblPlants; CDY44050; CDY44050; GSBRNA2T00079465001. DR Gramene; CDY44050; CDY44050; GSBRNA2T00079465001. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 703 858 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1678 AA; 188693 MW; 68AB9CEF3EAF2956 CRC64; MSQLTNEACI KVPHLGVVKD RLKDKKVLVV LDDVDQLIQL EAMAKETCWF GPGSRIIITT QNQKILKASG INHIYKLACE VRSLVGRLPL GLRVMGSYFR GMSEQDWIEA LPRKIMREQS DIEPGNRQFL NDAIDVGEGL IYDKAGISSV IGRDLDEKIT CASERAFIRL SNLQFLRTKR DGVNLQSMNF ISPKLRVLSF PMFHRTCFPS SFNPTFHVKL EMPFSKLEKL WGETKPLNLK WMELSYSNCL KELPDFSTAT NLYELDLTHS SSLVKLSSSI GNAINLQTLN LSHCSDLVEI PSSIITNLKS LDFYGYSSLV EVPFNIEEVI DSIYINLSYC SSMVEVPSST ENAINLKELN LKDCSRLVEI PFSIGNAFYL QKLNMSYCAS LVELPSSTGN TANFEEHDLD HCRVELPSSM RKLGGLSELE LKECSKLEVL LASINLESLG EVNLSDWSLL KNYPENSTDV QETDPWMGRI SGLRKLVQSG MEKLESLPPL PDSLWELDAD NGESLERLGS SFSNPDINLS FLNYLKLNQE EKDLIIQTPS NEYAVFPGGE VPQCFTYRSS GSSLTVKLNQ MPIGTSTKFK ACILCAGEDK KGLREWERAS VCCSITTSGG IALSSCLKTI EQFLPGNLYT FEFEVETDEV TSTELVFEFE VGYADLIKKG KTLEIKECGI MLVNMIESFG NDNSSGAING ARDGFDVFVS FEASNTISIV MNLKQTLKIE QYVRTNFLSH VLKELRNKGI DSFIDNDIER SKLIGPELVE AIRGSRIAIV LLSRNYASST WCLNELVEIM KGREEFGQTV VPLFYEVDPT DVKKQTGDFG KVLGKTCRGK EKEDIQRWKR ALTEVAQIAG FHSANGENEA ELIEYIATDV SNKLNLSAPC SDFDGLVGME SRMAEMRQVL QLDSDEVRKI GILGPPGIGK TTIARSLFNR HSQDFQLSVF MDNIKRKFVI MACSDDYSVK LDFQKQFMSQ LTNETGIKIP HLGVAKDRLK DKKVLVILDD VDQLVQLEAM AKETSWFGPG SRIIITTQDE KVLKASGIDH IHRVNLPSDD EALQMFCMYA FDQKYPKDGF KKLACEVRNL VGGLPLGLRV MGSYFRGMSE QDWREALPRL KIHLDRNGEI SSILKFSYDA LNDEDKRLFL HIACFFSGEP VEMVERCLEK CFQDVRQGLR VLSEKSLIYS KSGLIMMSTL LFQLGRQIVQ KESISEPGKR QFLNDAIDIG EVLSDDKAGN SSVIGIDLEW NKDITWTSER AFERLSNLQF IRILGKGVNP LKFLVNLFVR NSNLEKLWEE NKPLKNIKWM DLALSRRLKE LPDLSTAINL YYLDLSYCSS LVKLPSSIGN ATNLEKLSLN YCSSLVKLPS SIGNAINLKT LSLKGCSSMV KLPSSIWNIV NLEELNLENC SNLVELPSLL RSEIEKCTKS DCSRGSGKII DHLPFIAGLL PNPQFEKNNT ITYSESSTNI EELDPWIGRI LRLRRLVLSG MRKLVSLPQL PDSLLELDAE NCESLERLHC SFPNQDIRLN FANCFQLNQE ARDLIIQTPT NKYAVFPTEK VPICFSYRSS GSSLTVKLNR LPVGKSTKFK ACILCSYDEE NNFGLWETAS VFCTITFGGN ASIACNKRVE RVLPGNLCTF EVEVETEEGP FEDFEPSDIE LVREDDEIST ILILSSSY // ID A0A078I3B5_BRANA Unreviewed; 800 AA. AC A0A078I3B5; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=BnaA08g15570D protein {ECO:0000313|EMBL:CDY44049.1}; GN Name=BnaA08g15570D {ECO:0000313|EMBL:CDY44049.1}; GN ORFNames=GSBRNA2T00079464001 {ECO:0000313|EMBL:CDY44049.1}; OS Brassica napus (Rape). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=3708 {ECO:0000313|EMBL:CDY44049.1, ECO:0000313|Proteomes:UP000028999}; RN [1] {ECO:0000313|EMBL:CDY44049.1, ECO:0000313|Proteomes:UP000028999} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Darmor-bzh {ECO:0000313|Proteomes:UP000028999}; RX PubMed=25146293; DOI=10.1126/science.1253435; RA Chalhoub B., Denoeud F., Liu S., Parkin I.A., Tang H., Wang X., RA Chiquet J., Belcram H., Tong C., Samans B., Correa M., Da Silva C., RA Just J., Falentin C., Koh C.S., Le Clainche I., Bernard M., Bento P., RA Noel B., Labadie K., Alberti A., Charles M., Arnaud D., Guo H., RA Daviaud C., Alamery S., Jabbari K., Zhao M., Edger P.P., Chelaifa H., RA Tack D., Lassalle G., Mestiri I., Schnel N., Le Paslier M.C., Fan G., RA Renault V., Bayer P.E., Golicz A.A., Manoli S., Lee T.H., Thi V.H., RA Chalabi S., Hu Q., Fan C., Tollenaere R., Lu Y., Battail C., Shen J., RA Sidebottom C.H., Wang X., Canaguier A., Chauveau A., Berard A., RA Deniot G., Guan M., Liu Z., Sun F., Lim Y.P., Lyons E., Town C.D., RA Bancroft I., Wang X., Meng J., Ma J., Pires J.C., King G.J., RA Brunel D., Delourme R., Renard M., Aury J.M., Adams K.L., Batley J., RA Snowdon R.J., Tost J., Edwards D., Zhou Y., Hua W., Sharpe A.G., RA Paterson A.H., Guan C., Wincker P.; RT "Plant genetics. Early allopolyploid evolution in the post-Neolithic RT Brassica napus oilseed genome."; RL Science 345:950-953(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LK032577; CDY44049.1; -; Genomic_DNA. DR EnsemblPlants; CDY44049; CDY44049; GSBRNA2T00079464001. DR Gramene; CDY44049; CDY44049; GSBRNA2T00079464001. DR OMA; IYHESST; -. DR Proteomes; UP000028999; Unassembled WGS sequence. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 3. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028999}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000028999}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 29 167 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 800 AA; 91117 MW; C53D420FE1D75D4E CRC64; MKSRSHQRNQ TAASSLTLLA PPSSLPHNSK HHVFPSFHGA DVRKTFLSHV LKEFRSKGID LFIDKDIERS KSIGPALIEA IRGSRIAIVL LSENYASSTW CLNELVEIIK CRQEFGQTVM PIFYQVNPTD IKKQKGYFGK VFRKTCKGKR KEEIQRWKHA LTQVAQIEGL MIIPLSRETE AEMIDDIATD VSNKLNNSAP SSRLPLGLRV MGSYFRGMSE QNWTEALPRL RSHLDRDGEI ANILKFRLRV LAEKSLISIE SRWIKMSELL VQLGRKIVRE QYVSEPWKRQ FLNEAIDIGE VLSDDKADSR SVIGINLNEE ITSCTSERAF ERLSNLQFLR IRSYRTNLRS IDYVSRKLKL LIWPIAEQLP RPMFPMTCFP YSFNPNFLVK LEMPFSKLEK LWEENKPLSN LKWMDLTNSS NLKELPNLST ATNLQELDLS YCSRLEELPD LSTATNLQKL ELRHCSSLVE LPYSIGNAVN LRELDLNNCS SLVKLPSSIG NAVNLKEMNL SHCSNLVEIP SSIGNALPSS MRNLGRLSEL KLKECSKLEV VLTNINLESL KELNLSGCSL LKIYHESSTD IQELDPWLWR KSCLQFLALR GMKKLVSLLP LPDSLLELDA EDCESLERLD CLFPNPNIRL NFLNCFKLNQ EARDLIIRTP TNQYAVFPAG EVPMCFTYRS YGSSVTVNLN QNPLGTSTKF KACFICAVED EEDFQNSESV FCSITSGGIA LTAFFKILHR FSPGHLYTFD VEVETEEVTS TELVFEFDLG YSDTNVKIKE CGIFQLLEVP LLSFRDGDED // ID A0A087FX98_ARAAL Unreviewed; 859 AA. AC A0A087FX98; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK22250.1}; GN ORFNames=AALP_AAs66747U000400 {ECO:0000313|EMBL:KFK22250.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK22250.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK22250.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK22250.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL990937; KFK22250.1; -; Genomic_DNA. DR OMA; DINLESX; -. DR Proteomes; UP000029120; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 11 149 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 859 AA; 96301 MW; EBEFC10FFC330176 CRC64; MASSSSSTRT WKYDVFPSFS GEDVRKSFLS HFLEKLQGKS IITFIDNGIE RSRTIELELL LAIRQSRISI VVFSKKYASS TWCLNELAEI YECHEESDQM VIPVFYEVDP SHVRKQTGDF GKAFDVTCRG KTEDDIERWK KALAKVAGIA GYDSQKWSDD STMIEQISTD VLKKLLWTPL DDFPDYVGIE AHVKTIMDSK LCLDSGGVRM VGIWGPSGIG KTTIATALFN RLSTQFDHRA FLTYKRAMQD KKIADVRMKL DWANHFLSEI LGQKDIKIAS LGHVKQSLKH RKVLIVLDDV DEIELLEALV GKAEWFGSGS RIIVVTQDKA LLESHGIDDI YEVELPSKDL ALQIFCQSAF GKTSPPDGFK ELAVEVAKLA GDLPLGLNAL GSSLRKKRKE HWVDMMPRLR SGLDGKIKKT LRLCYDGLDE KDDQDIFVYI ACLFNAKFLP CSFSGENLVE LIMKDSKLEK LWEGSDQPSR SLKVINLSGS RALKEIPDLS NATNLEILNL CFCSSLVTLP SSIRNLKKLR ELKMFLCSNL EVLPTDANLE SLDYLDLTAC SRLRTFPRIS TNISRLRLDG TAMEEKDCSW IENLSGLTEL YWENCSLRFM PSNFNLELLV RLKMTESKLE KLWEGVQSLT NLKSMQLSNC ESLKEIPDLS KATNLEVLDF SGCINLKVIP DLSKATNLET LNLSGCINLK VIPDLSKATN LEVLNLSGCK NLKALSMVGC TSLEDLPTDI NLESXXXXAL SMVGCTSLED LPTDINLESL TSLDLSGCAR LTSFPQFSTN IEVLDLSYTA IEEVPSWIEE IAGLSDLWMS GCTSLETRRN PSYSQMSDMQ SYLVKKCLHT SRIELVEVP // ID A0A087FXW6_ARAAL Unreviewed; 959 AA. AC A0A087FXW6; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK22468.1}; GN ORFNames=AALP_AAs64007U000400 {ECO:0000313|EMBL:KFK22468.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK22468.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK22468.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK22468.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL988864; KFK22468.1; -; Genomic_DNA. DR OMA; EIRGNMK; -. DR Proteomes; UP000029120; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 13 143 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 959 AA; 107353 MW; AFA9BC0D68B2143C CRC64; MDLCFWNRIL DDFGGQDVRR AFLSHILMEF EIKGITLFID NEIKRGESIA PELKRAIRES RVAIVMLSRK YASSTWCLDE LVEIMECRKE LGQLVVPVFY EVDPSNVRKQ TGDFGERFRR TCEGKTKGET ERWRQALRDV ANILGYHSRD WTNEAALIES IAIDISQKLI NSTPSCDGDE ADMFAEITSG ISVTSNDSES SSDSDNPDGM DAHMEKMKEL LCLESDEVRM IGISGPRGIG KTTIANNTYD QFSHQFHFST ILANINEYYA SNCRSEEDAK LQLTRQLLFQ LSNQNDDTDE IFHLGVAQET LKDKKVLVVV DDVDGLRQLD ALEKEIRCFG PGSRIIVITK DQRLLKAYGI DHIYNVDYPL PDEALQIFCM YAFGQKAPYD GFADLAQEIT TLSGKLPLGL RLMGTYLQYM SKQEWTDQLP RLRTSLDGEI ESVLKFSYES LCGEDKESFQ QHIACSSYDD SSEMVEEFFA KTFSDVRQEL IISNHDLTED LFTRERAFEE ISNGFLRWEY SPLTCWPSML HPEFLVELYM PKSKLEKLWE GVRSLENLRL VDFSSSKNLK ELPNLSTATN LKILNLRCCT SLVELPSSIG NATNLHNLHL EYCASLVKLP SSIGKAINLT ELYLTGCSSL VELPASIVNA NNLQKLHLGY CTSLVKLPSL IGNARNLKEL CLSGCSSLVE LPAYFVKATS TLQKLNLEYC SSLVKLPSSI GNAINLKELY LIGCSSLVEL PASLGKATNL EILDLSNCSS LVELPSSIEN LSRIHYLDLS NCSCLVELPS SIWNATNLGE LILKNCSSLV ELPYSIGNAT RLWKLDLSNC SSLVELPSSI GKATSLEYLY LSNCSSLVEL PYSIGHATSL RYLYLNNCSN LIEVPSSLGY ATNLKKLDLS WCTNLVEVPA SIRNSTSLWQ LDLDNCSSLL NVSSSIGNGV HLKKLDLSLC TDHHAPVVM // ID A0A087GFX7_ARAAL Unreviewed; 1097 AA. AC A0A087GFX7; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK28779.1}; GN ORFNames=AALP_AA7G046500 {ECO:0000313|EMBL:KFK28779.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK28779.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK28779.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK28779.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM002875; KFK28779.1; -; Genomic_DNA. DR OMA; RHITIVE; -. DR Proteomes; UP000029120; Chromosome 7. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 50 188 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1097 AA; 123665 MW; 9A9ACE57C5E4FD98 CRC64; MDSSFFFTIL AAAIGLFLTF RKFRSHQQNK ENSSSSSSSP PPPPSSSHNW TYHVFPSFRG EDVRKDFLSH IQKEFGRKGI TPFIDNDIKR GESIGPDLIK AIRGSKIAVV LVSKNYASSK WCLDELVEIM KCREEVGQTV MAIFYKVDPS HVKKLTRNFG KVFRKTCAGN SKKDIERWRQ ALVKVATIAG YDSSNWDNEA AMIEKIATDV SNELINFVPS SDFDGFVGMR AHMENMNLFL RLDSNEVKMI GIWGPSGIGK STIARVLYST YSHQFQLSVF MENIKRHHQN IRGYDEYSSK LHLQKEFLSH IINHEDIKIH HLGVAQDMLK DKRVLVVLDD VDQSVQLDAM AKEVGWFGSG SRIIITTQDK KLLNAHGISH IYERQFLVDA RDICKVLNTD TVSRGSVIGA IINFSEIEDE LDICDMALES MSCIQFLRLN DGKYYQNSYL PQKYNLPRRV RLLDWKWFPK TCLPSNFNLE FLVELKMQHS KLVKLWGGTK TIRNLKWMDL SHSYNLRELP DLSTANNLRE LDLSGCSNLV ELPSSIGIAI NLRKLLLLNC SSLIVIPSSI GSAINLEELN LHGCSALVEL PSSIENAIML KQLDLGDCSS LVELPSFIGN VTRLEDLNLR GFSSLVELPY FIGNDIKLKR LNLSGWSSLV ELPSTIGKIT SLEDLDLSGC SRLVKLSYCI GSITNLRKLN LSGCSRLAEL QSSIGNSTNL EELNLTDCSN LVELPSSIGN ATNLEILNLS GCSKLVKLPS SMGNVTGLGK LDLSGCSSLA ELPSSIGNIT RLWKLDLNGC SSLVKLPSSI GNLHKLSRLR LKGCSKLEAF PFNMESLVEL DITDCSLLKE FPEISTSIEL RMEEIPPWSY LDLQMSPWIK ELSQLYRLEI KGCTKLVSLP QLPDSLRSLD AENCESLESL HCSFHNNKFS RLEFANCFKL NREARDLIIS KVPTCDRVYL PGEKVSTHFT YRATGNSLSM KLNGIDTHFA THLSFKACVL LVNKGDVEVV DWSRMRDRNA LKLTLPKKHR SVESLQVYIL VSIDTRRVTI DTNSRQRRKS RLIRNDDNIN LIERRKLQRM VFEDAQHSPS KAKDGIQ // ID A0A087GK43_ARAAL Unreviewed; 1406 AA. AC A0A087GK43; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK30245.1}; GN ORFNames=AALP_AA7G236500 {ECO:0000313|EMBL:KFK30245.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK30245.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK30245.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK30245.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM002875; KFK30245.1; -; Genomic_DNA. DR Proteomes; UP000029120; Chromosome 7. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 2. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 2. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 18 152 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 1292 1312 {ECO:0000256|SAM:Coils}. FT COILED 1361 1391 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1406 AA; 159761 MW; 3C08D17A229F0450 CRC64; MDSSSSSSTH PSSLSRNLKH HVFPSFYGPD VRNDFLNHIL KEFSSKRIDT IITRGESIGL DLMREIRGSK IAIVILSRNY ASSSWCLDEL VEIMKCREVL GQVVVPIFYK LDSIDVKKQT GDFGNVFRET CFGKTKEDTE RWRQALAEVA TIAGYSSLDW DNQQAMIEKI ATHIYNIFTN YIQSDIDGQV GMEAHLKKME ALLGLESDEA RMIGIWGPSG IGKTTIARCL FNHLSHQFPL SVFMENIKGP RGYDDYSAKL QLQKDFLCQI LNQKDIMIPH LGVAQDMLKD KKLLAVLDGV DSLAQLDAMA KETRWFGPGS RIIITTQDHK LLIAHGIDLI YEVMGSYLRG MSKQEWTEAL PRLRSSKMGS ITKDLTDLRQ ELFITNQDLK EYSSTSERYF EDIIYIYCED RLQYSFASHL SMGFRRKRID AFVNSEETLD VFDSVNASVV IFSKSCFSST SYLDMLVRVL QCQRKTGQLV VPVFYGISPS DVVVHEQESG DQIREWSSAI QELRELPGHQ SREECTEREF VEKIVKDVYE KLFPAQQIGI NSRLLEIEQL LCKQPWGIRR IGIWAMKVID FASGNPLALS FYGKELKETK LSEMETSFLE LKLHTPYKKI HDLFKSSYET LNDSEKNIFL DIACFFVGED VDYVLQLLEG CGFFPHVGID VLVEKCLVTI SENRMRMHRI IQDFGREVIN GETVVVERRS RLWEPLTIKS LLEDEKLKAN GDSKATYTRA LGTEDIEAIY LDTSNLLFDV KPTAFENMLN LRLLKIFCSS YETLYGLCLP KGLQSLPCEL RLLHWEKYPL QSLPQDFDPD HLVELNMSYS KLHKVWTGSK NLDMLKIAKL CHSQQLIEVD DICKAQNIEL IDLEGCTKLQ SFPDTGQLQH LRVVNISGCR EIKSLPKLPA SIGKATNLEI LDFGDCSSLI KLPSSIGNVT NLHNLQELDL NHCPSLLKFP SSSIENVTNL KRSNLTNLKV LDLSNCRSMM EFPASIEEAI NLEKLTLKYC SSLVKLPFSI GNAISLKELY LTGCSSLMEL PASIGNATNL EILDLGDCLN LIKLPSSIGK ATNLEKLYLE YCLRLEELPF SIGNATNLRK LSLAGCSSLV VLPSSIGNAT NLQELNLEYC SSLVELPSSF GNAINLKKLY LTGCSSLVEL PSSIRNSTSL IYIDLEEDNN LPTVNFSYYS KLRYIEVRRA KRGNFFVLKG EQNDENSLSL ILRIVYENGR VRNLHFLFYK EDNTASKASS VIIKELELTD QNVTFIAEMI DILLVNMIPT WKTDVKVDHL IHSQLNQNSR SHQNEANTKR QEETAVHDGC ESFSHPCSQS DEEDKHCVDA IEVEDGSSNQ EGEDATKPVS LKEEEILSKE LEEIEAKYQD EMKKIARKRE ETIMETKKKR KLEYIR // ID A0A087GK44_ARAAL Unreviewed; 1112 AA. AC A0A087GK44; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK30246.1}; GN ORFNames=AALP_AA7G236700 {ECO:0000313|EMBL:KFK30246.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK30246.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK30246.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK30246.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM002875; KFK30246.1; -; Genomic_DNA. DR Proteomes; UP000029120; Chromosome 7. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 2. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 2. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 27 162 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1112 AA; 125127 MW; 1EBC4478F90F3188 CRC64; MASSSSSSSS SSSPPALSPP SSSSPNRKYN VFASFSGRDI GRSFVSDILE VIRSKGIHTS KMIDSLRINS SGVEAIRGSR IAIIMLSRNY ASSPRYLNEL VEIMKCREEL NQVVVPIFDE FDPIDVRTQT GDFGNVFRET CKGKTKEETG RWSRALAQVA TIAGYHSRNW DTEWHKMENI ATEISNILKY STPSRDLQRI SNRLLHGVHI YCADKLQSSF ASHLSVDFSR KRIASFVNCN RTLDVIEGAI ASVVVISKDY LSSPSCLDKL VRVLQWRSQT GLQVVPVFYG ISPLDVVVQE NESAGRISVW SSALQELRDL PGHQSREESS ECEVVEEIVK DVYEKLFPTE QIGINSRLLE IEQLLCKQPW GIRRIGIWGM PGIGKTTLAK AVFDQVSGGY EASCFIKHFD EAFHEKGPHR LLEEHFGKIL KDLPRACSSI TRCSLPKDKI NKKRTLVVLD DVHNPLVAES FLGAFHWFGL GSLIIITSRD KRVYRHCQIN HVYEVQSFCE SEAMQLFSQC AFGKDIRELN LLELAGEVID YANGNPLALS FYGKGLKGKK MSEIETSFLK LKLRTPHMIH DLFKSSYETL NDREKNIFLD IACFFRGEIV DYVMQLLEGC GFFPHVGIDV LVEKCLCISR GVTGCGNLGA LNFYLKMTNW KTMKKQPGTE DIEGIFLDTA NLLFDVKPTA FENMLNLRLL KIYSSSDENH YGLRLPRGLE SLPDELRLLH WENYPSQFLP QDFDPRHLVE LSMSYSKLRK LWTGTKNLDM LKIARLRHSQ QLTEVDNIFK AQNIELIDLE GCTKLQGFPA TCRLQHLRVV NLSGCREIKS FPEVSPNIEE LYLRRTGIRE LPISIGNATN LKKLYLTGCT NLVELSASIG NTTNLKVLDL GDCSSLKKLP SSIGNATNLQ ELNLEFCSSL VELPSSIGNA TNLKKLCLDG CLRLVELPSS IGNATNLEIL NLSYCSTLRE LPSSIGNAVN LKKLYTIGCS RLVELPSSIG NVANLKILDL EYYLSFIGHS SSKRNSTRRM STKKGIVGRN EAKTQTQEEI AFHEGCELVS HSRTSDFPQS HKEDNHCIDA MKVATGGPIN RKRQPNHNAP RRKRCHRRNR KR // ID A0A087GK45_ARAAL Unreviewed; 1143 AA. AC A0A087GK45; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK30247.1}; GN ORFNames=AALP_AA7G236700 {ECO:0000313|EMBL:KFK30247.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK30247.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK30247.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK30247.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM002875; KFK30247.1; -; Genomic_DNA. DR OMA; SFENATH; -. DR Proteomes; UP000029120; Chromosome 7. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 2. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 2. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 27 162 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1143 AA; 129245 MW; 0C58E3BB8DD24043 CRC64; MASSSSSSSS SSSPPALSPP SSSSPNRKYN VFASFSGRDI GRSFVSDILE VIRSKGIHTS KMIDSLRINS SGVEAIRGSR IAIIMLSRNY ASSPRYLNEL VEIMKCREEL NQVVVPIFDE FDPIDVRTQT GDFGNVFRET CKGKTKEETG RWSRALAQVA TIAGYHSRNW DTEWHKMENI ATEISNILKY STPSRDLQRI SNRLLHGVHI YCADKLQSSF ASHLSVDFSR KRIASFVNCN RTLDVIEGAI ASVVVISKDY LSSPSCLDKL VRVLQWRSQT GLQVVPVFYG ISPLDVVVQE NESAGRISVW SSALQELRDL PGHQSREESS ECEVVEEIVK DVYEKLFPTE QIGINSRLLE IEQLLCKQPW GIRRIGIWGM PGIGKTTLAK AVFDQVSGGY EASCFIKHFD EAFHEKGPHR LLEEHFGKIL KDLPRACSSI TRCSLPKDKI NKKRTLVVLD DVHNPLVAES FLGAFHWFGL GSLIIITSRD KRVYRHCQIN HVYEVQSFCE SEAMQLFSQC AFGKDIRELN LLELAGEVID YANGNPLALS FYGKGLKGKK MSEIETSFLK LKLRTPHMIH DLFKSSYETL NDREKNIFLD IACFFRGEIV DYVMQLLEGC GFFPHVGIDV LVEKCLVTTS KNRLRMHNII QDFGREIING ETVHIERRHR LWEPWSIKFL LEDDKLEDYE EATCRRALGT EDIEGIFLDT ANLLFDVKPT AFENMLNLRL LKIYSSSDEN HYGLRLPRGL ESLPDELRLL HWENYPSQFL PQDFDPRHLV ELSMSYSKLR KLWTGTKNLD MLKIARLRHS QQLTEVDNIF KAQNIELIDL EGCTKLQGFP ATCRLQHLRV VNLSGCREIK SFPEVSPNIE ELYLRRTGIR ELPISIGNAT NLKKLYLTGC TNLVELSASI GNTTNLKVLD LGDCSSLKKL PSSIGNATNL QELNLEFCSS LVELPSSIGN ATNLKKLCLD GCLRLVELPS SIGNATNLEI LNLSYCSTLR ELPSSIGNAV NLKKLYTIGC SRLVELPSSI GNVANLKILD LEYYLSFIGH SSSKRNSTRR MSTKKGIVGR NEAKTQTQEE IAFHEGCELV SHSRTSDFPQ SHKEDNHCID AMKVATGGPI NRKRQPNHNA PRRKRCHRRN RKR // ID A0A087H6R1_ARAAL Unreviewed; 1279 AA. AC A0A087H6R1; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK37813.1}; GN ORFNames=AALP_AA3G032600 {ECO:0000313|EMBL:KFK37813.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK37813.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK37813.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK37813.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM002871; KFK37813.1; -; Genomic_DNA. DR OMA; ELNLEWC; -. DR Proteomes; UP000029120; Chromosome 3. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00367; LRR_CC; 6. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 7 29 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 216 352 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1279 AA; 143006 MW; F13CE443FF47BE65 CRC64; MDFYLSLRAL AATIFELFGT IFTLFGVIFT RLGTICTLLG SMFHMVYEKI RVQENTSHPS PPSSASLLSQ SPSMASSASL TCQSPVMAFT SLSLSPPSPP SPPSSTYLLC QSPTMASSSL SLSPPSPPSP PSSTSLLCHS PKMASSLSLS PPSSPSLICQ SLIMASPPSL LSQIPTLASS PPSPLSSPSL ICQSPIMASP SSLPLSLPLS SPSRSWEHDV FPSFHGPDVR KDFLSHILKD FRSKGIDLFI DNNIRRGESI GPELKKAIRG SKIAIVLLSK NYASSSWCLD ELVEIMKKEL GQTVITIFYK VDPTDVKKQT GDFGKVFKET CQYKTKEKIH TWRKALEGVA TIAGYHSSKW DDEATMIEKI GDDISKMLIG LAPSPGLGLL IGMGAHMEEM QQLLRLDLED EVRMIGIWGP VGIGKSTIAR FLFHQLSRNF PQSAIMEIRE NYPRPCLDEG SAQLKLQNLM LSLVINHKDT MITHLGVAPE RLKDRRVLLI LDDVDQLAQL HALAGGIRWF GPGSRIIITT EDQKILNDHG INLIYKVDYP IDEEALQIFC SHAFGQKSPY DGFEELAREV IRLSGKLPLG LKVMGSYFRG MSKDEWTMAL PGLRESLNGE IESILQFSYD ALCDEDKEIF LHIACFFSNN YGMVERVEEH LAKKFLNVRQ RLQVLVEKSL IYFNDQRKIE IHTLLAQLGK TIVHKQSREP RQRQFLVGGK DICDVFTDPA AVTRSVIGIS EFLVELNMSF SKLKKLWEGI KPLQNLKWIN LDYSKDLKKL PNLSTAINLE ELKLNGCLSL VKLPSSIGNA TNLQELNLVG CSSLVKLPSW IENATNFQKL NLAWCSSLVE LPSSIGNINL QELNLKRCSS LVKLSSFILD ATNLQELNLE GCSSLVELPS SIGNATNLQE LNLEWCTSLV ELPSSIGNAT NLQELNLEWC SSLVELPSSI GNLHKLTKLN LRMCSKLEVI PTNITLESLK ELDLRYCSSL KSFPEISTNI EVLKLSGTAI EEMPSSIMSL FRHKKLEMSY YENLNEYMPA FESITELHLG NIQEIGPWVK GCSRLKLLDV SYCRKLVSIP QLPDSISKVN AYNCESLERL DCSIRNPNIH HLNFGNCFKL NQEARDLIIQ TPTRRKYSVL PGEEVPACFT YRASGSSLTV KLNEKPLGTS IKFKACILLV HKGQDHYWAS VHVDCRIITS NKVSCRSYDL ERALSEHLYI FEVELEEVTS TELVFEFNLK DFWFNVEQFW EIKECGVLQI LEHQGMKILD LSEDSDKEM // ID A0A087H6R2_ARAAL Unreviewed; 1299 AA. AC A0A087H6R2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK37814.1}; GN ORFNames=AALP_AA3G032700 {ECO:0000313|EMBL:KFK37814.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK37814.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK37814.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK37814.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM002871; KFK37814.1; -; Genomic_DNA. DR OMA; RCIINTE; -. DR Proteomes; UP000029120; Chromosome 3. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00367; LRR_CC; 9. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 103 241 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1299 AA; 147275 MW; 5E24E9834B6A7690 CRC64; MFRNKNWMST LNLFENLKTI PNLLIFKNYP IFMEQVFLFS STHNQSCFHL LTKVQSHLHF ISVFVSEKLC EIFSYSLSIF TLMDSSLSST TCVPPPSSLP RNWIHNVFPS FHGPDVRRAF LSHFLKECKS KGIDPFIDNE ITRGEFIGPE LKKAIQGSRI AIVMLSKRYA SSSWCLDELV EIMKCNEDLG YTVMVIFFEV DPTDVKKQMG EFGKVFEETC QGKKEEVIRR WSQALAEVAT IAGYHSSKWD KEAEMIEKIV TDVSKMLNNS TSRDFEYLVG METHMEKMRL LLRLDLDEVR MIGIWGTPGI GKTTIAKFLF NQHSKDFQLS VFMANIKRTC TIPDFSDDND AKLLLQQKFL SHILKEKDIE VPHLGVAQDR LKDKRVLVVL DDVDQLVQLE AMAKETGWFR RGSRIIITTQ DQKLLKDHGI NHIYEVPFPP SNEALHMFCT YAFGQNSPKD GFKELALEVT SLVDSLPLGL QVMGSYFKKL SEQDWSMELR RFKDSLDKRI GSILRFSYDA LRREDRELFI HIACFFNNEY KNKVVGHLEK SFSGVSRGLD VLVEKSLISI DQERIGMHSL LAQLGKEIGK RQFLMDRKDI CEALTDPTVD TRSVIGISSR QWDIKFNITE RAFEGMPNLQ FLRLGLGGIK IVSWRKRLKY ISPKLQLLDW ESAPITCLRC IINTEFLIEL NMRHSKLKKL WEGIKPLQNL KWIDLSFSYN LKKLPNLSTA TNLRKLVLDC CSSLVELPSS IGNATNLQEL VFSGCSSTLV ELPSSIGNAT NLKELDLSCC SSLVELPSSI GNATNLQKLY LSECSSLVEL PSSIGNATNL QELVLSYCSS LVELPSSIGN TTNLQKLDLS WCSSLVELPS SIGNATXXXX XXXXXXXXXX XXXXXSLVEL PSSIGNATNL QELVLSYCSS LVKLPSSIGN ATNLQELVLS YCSSLVELPS SIGNATNLQE LVLRSCRSLV KLPSSIGKAT NLQDLNLSWC LSLVELPSSI GNLQKLTKLN LEWCSKLEVL PTNINLESLK ELNLTRCMSL KRFPEISTNI EVLKLSGSDS MSYYENLKEY PHAFDNITEL SLTDIQEIGP WVKGWSRLQK LDVSECRKLV SIPQLPDSIL EINAKNCMFL EKLDCSFRSP NFHHLNFRDC FKLNQEARDL IIQTSTRSKN SVLPGEEVPA CFTYRASGSS LTVKLNEKPL RTSIKFKACI LLVYKGQDHY GEFVHVDCRI ITSNKNSCRS YDLGLVSSKH LYIFEVEAEE VTSTDLVFEF NLFETDNLGD DKNHNWKIKE CGILQIRLC // ID A0A087H6R3_ARAAL Unreviewed; 722 AA. AC A0A087H6R3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFK37815.1}; GN ORFNames=AALP_AA3G032800 {ECO:0000313|EMBL:KFK37815.1}; OS Arabis alpina (Alpine rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; OC Arabis. OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK37815.1, ECO:0000313|Proteomes:UP000029120}; RN [1] {ECO:0000313|EMBL:KFK37815.1, ECO:0000313|Proteomes:UP000029120} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120}; RC TISSUE=Leaf {ECO:0000313|EMBL:KFK37815.1}; RA Willing E.-M.; RT "The reference genome of Arabis alpina."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM002871; KFK37815.1; -; Genomic_DNA. DR OMA; IMASSWR; -. DR Proteomes; UP000029120; Chromosome 3. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029120}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029120}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 70 208 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 722 AA; 79468 MW; 893C1F5B5FAB1531 CRC64; MGSSLLFGTL AAAALGCFTL FKKIRFHQGX XXKDSSSLPP SLPPSPSQSL SSSSSLSLSS PPSSEFSHSF TYDVFPSFHG TDVRKAFLSH TLKEFKSKGI NSFIDNDIER SKSIGPELLD AIRGSRIAIV LLSRNYASSS WCLNELVEIM KCREEMGQIV MTVFYEVDPT DVKKQTGDFG KAFKKTCVGK KKEEIEQWKQ ALAEVATIAG EHSTKCNDEA AMIEKIATDI SERLHYSMPS SDFDGFIGMG AHMERMGPFL RLDSSEVRMI GIWGPSGIEG CQDSSFRSCK RTIERQENVP PPPEALQIFC MSAFGQNSPY DGFEKLAWKV TDLVGKLPLA LRVMGSYFRG MSKPEWKKAL PSIEKMEDYL PDCFVDMRHG LDVLAEKSLI SRSISGVIEM HKPLEQLGRE IVRNESVREP GQRRFLFDAR DICKVLNDET GSGNVIGIQF DLSELSGDSK EPISLTTSML EKLWEGIQPL RNLNRMDLSY SESLKELPDL STATNLETLD LSNCTSLVEL PTSIGNALNL MKLDLVHCSS LVKLPSSFGN ITNLQKLDLN NCLSLVELPS SIGDLINLEK VDLSHCSSLM ELPYSIGNLI NLKKVDLSHC SSLVKLPSSI GNAKFLQKLD LSGCSSLVKL PSSIGNATNL TELYLKGCSS LVELPASIGN ATNLQKLYLN NYSSLEKLPS SVGSASNLEK LDISNVSNNS NNNKESLRLV VF // ID A0A087QW20_APTFO Unreviewed; 507 AA. AC A0A087QW20; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFM05424.1}; DE Flags: Fragment; GN ORFNames=AS27_15864 {ECO:0000313|EMBL:KFM05424.1}; OS Aptenodytes forsteri (Emperor penguin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; OC Aptenodytes. OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM05424.1, ECO:0000313|Proteomes:UP000053286}; RN [1] {ECO:0000313|EMBL:KFM05424.1, ECO:0000313|Proteomes:UP000053286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM05424.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL225954; KFM05424.1; -; Genomic_DNA. DR Proteomes; UP000053286; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053286}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFM05424.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053286}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFM05424.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFM05424.1}. SQ SEQUENCE 507 AA; 58970 MW; 1A5E4FE6BA796DE2 CRC64; DAMEGEALVI KCPQWSSTVK VTWYHMDTNK IIPEEEEGSR IFSLKQFLWF LPTSREDSGN YTCVIHFSNN RKRSFNMSVQ VHPYKQGVCF PSQIRYPNDT GRGKIVCPTI DNYKNATIIQ WYKDCRPLQG ERYFKKEKYI FINSPRKEDD GYYTCKFIYT HKGNVFNVSA TRIFISKAKH LALLPQILFP KDKDVIEVDL GASLSLKCQA RLGIKKQPMA VVTWDVDNIP VKSLDSSRFH EKTHFFEGRE QEYYGETTLH ITEIKKEDLQ ANFTCVVVNK VQNTKATVML QLKAQCEVGL PNVLLIVGSL VLLVAIAASV ILYQFFRVDI VLLYREIFQP YSVKDDGKIY DAYVIYPRSH TNEANFVEYF VYHSMPDILE NKYGYKLCIY GRDIYPGEDT ASAIEKRMQK SRRLIILLTH QLINCKEPAY DQHIALYNAL IQNGTKVILL EMETIGTYEK LQESLRFIVK QQGTVKWKEQ HTVHPQSSNS RFWKQVRYHM PLTLKSS // ID A0A087QW22_APTFO Unreviewed; 548 AA. AC A0A087QW22; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|EMBL:KFM05426.1}; DE Flags: Fragment; GN ORFNames=AS27_15866 {ECO:0000313|EMBL:KFM05426.1}; OS Aptenodytes forsteri (Emperor penguin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; OC Aptenodytes. OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM05426.1, ECO:0000313|Proteomes:UP000053286}; RN [1] {ECO:0000313|EMBL:KFM05426.1, ECO:0000313|Proteomes:UP000053286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM05426.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL225954; KFM05426.1; -; Genomic_DNA. DR Proteomes; UP000053286; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053286}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFM05426.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053286}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 548 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001828334. FT TRANSMEM 339 361 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 19 114 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 142 217 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 385 542 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFM05426.1}. FT NON_TER 548 548 {ECO:0000313|EMBL:KFM05426.1}. SQ SEQUENCE 548 AA; 62938 MW; FE2B176F2EA0E75C CRC64; QQKMTSTFLL IGHVILLIPL SSAEECVICD YFVLVGEPTV ISCPVITLPV LHSDYNLTWY KNGSATPVTT ERDARVHQRG GLLWFIPATL EDSGLYECDV RSLNHSDQKT IHLTVFKNDN GLCFNGKMKF EQKVTSTNTG KIVCPDLEHF KDEDNQPEVH WYKECKPGFL EDKRLLLAEG ANAVFIHNVT VQDRGNYTCR MVYTYMGKQY NVSRTISLEV KEGPLRMRPE FIYPKNNTIE VELGSHVVME CNISSGINGL IPFWQVNDED VDSFDSTYRE QSYEEGMPHG LAVSGTKFNI SKVKVKDYAH KFFCHFIYGT QQFTAYIKLE RPAQNIQCYL IGGGVSLVFL VFFTLFIYKI FKIDIVLWYR DSCHPFLGKK VSDGKIYDAY ILYPKNRASC LYSSDIFALK ILPEVLERQC GYNLFIFGRD DLPGEALIST ADEKIRQSRR VIIVLVPEPS CYSILEDVSE KQLAMYNALI QEGIKVILIE LEKIQDYATM PESIRYIKQK HGAIRWKGDF SERSHSARTR FWKKVRYHMP SRKNGSSS // ID A0A087R0J0_APTFO Unreviewed; 1026 AA. AC A0A087R0J0; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-MAR-2018, entry version 23. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFM06994.1}; DE Flags: Fragment; GN ORFNames=AS27_10534 {ECO:0000313|EMBL:KFM06994.1}; OS Aptenodytes forsteri (Emperor penguin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; OC Aptenodytes. OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM06994.1, ECO:0000313|Proteomes:UP000053286}; RN [1] {ECO:0000313|EMBL:KFM06994.1, ECO:0000313|Proteomes:UP000053286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM06994.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL226018; KFM06994.1; -; Genomic_DNA. DR Proteomes; UP000053286; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053286}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFM06994.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053286}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFM06994.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFM06994.1}. SQ SEQUENCE 1026 AA; 118025 MW; E31DFAAEE8CC5CC4 CRC64; LLSGAWFPKS LPCDVNAFEG TVTVDCTDRR LMEVPRGIPT NATNLTLNIN HIPHISPTSF AHLENLVEID FRCNCVPVRM GPKDHVCTSR PEIENGSFAA LTRLKSLYLD ANQLLEIPQG LPTTLSLLSL EANSIFSIQR ANLSELGNIE ILYLGQNCYY RNPCNVSFEI EKTAFLELKK LTILSLKSNN LTHIPPNLSS TLKELYIYNN MIQVIQEQDL SALHNLEILD LSGNCPRCYN APYPCIPCPK STIEIHSKAF YSLKNLRILR LHSNSLQSIP SIWFKNIRNL KELDLSQNFL IKEIGDAQFL KFIPGLVELD LSFNFELQMY SPSLNLSKTF SSLSNLETLR LRGYVFKELR EGNLDPLLSL RNLTVLDLGT NFIKVADLKV FKEFPALKFI DLSVNKISPS SGESNFYGFC SNPRISVEQY NRQVLHEMHY FRYDEYGRSC RSKDKEAASY QSSVNEECLK YGETLDLSRN NIFFINPSDF RGLSFLRCLN LSGNAISQTL NGSEFYYLSG LKYLDFSNNR IDLLYSTAFK ELKLLEILDL SNNKHYFLAE GVTHVLSFMK NLAHLKKLMM NENEISTTIN TGMESQSLQI LEFRGNRLNV LWMDGNARYL SFFKNLTSLE QLDISFNSLS FLPHGVFEAM PPELKILNLT NNQMKSFNWG KLHYLKKLVT LDLSNNLLVT VPQELSNCSS TLQELVLRNN RIQRLSKHFL RGAFKLKYLD LSSNRIQIIK KSSFPENVIN NLRMLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSTSTVLGF MVFTVTSHLY FWDVWYSYHY CTAKLKGYRR LSLPDACYDA FIAYDNKDPA VNEWVLTELV ERLEDQKARQ FNLCLEERDW LPGQPVFDNL SQSIQLSKKT IFVLTNKYIK SGSFKTIFYM AHQRLLDEKM DVIILIFLEK VLQKSRYVRL RKRLCRSSVL EWPTNPRSQP YFWQCLKNAI ATSNTLAYNK LLQETV // ID A0A087R9F3_APTFO Unreviewed; 437 AA. AC A0A087R9F3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFM10107.1}; DE Flags: Fragment; GN ORFNames=AS27_04970 {ECO:0000313|EMBL:KFM10107.1}; OS Aptenodytes forsteri (Emperor penguin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; OC Aptenodytes. OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM10107.1, ECO:0000313|Proteomes:UP000053286}; RN [1] {ECO:0000313|EMBL:KFM10107.1, ECO:0000313|Proteomes:UP000053286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM10107.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL226222; KFM10107.1; -; Genomic_DNA. DR Proteomes; UP000053286; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053286}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFM10107.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053286}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFM10107.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFM10107.1}. SQ SEQUENCE 437 AA; 50291 MW; C51B7A246A615D82 CRC64; GSSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRIW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A087RJP8_APTFO Unreviewed; 874 AA. AC A0A087RJP8; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFM13702.1}; GN ORFNames=AS27_04174 {ECO:0000313|EMBL:KFM13702.1}; OS Aptenodytes forsteri (Emperor penguin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; OC Aptenodytes. OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM13702.1, ECO:0000313|Proteomes:UP000053286}; RN [1] {ECO:0000313|EMBL:KFM13702.1, ECO:0000313|Proteomes:UP000053286} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM13702.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL226406; KFM13702.1; -; Genomic_DNA. DR RefSeq; XP_009286715.1; XM_009288440.1. DR GeneID; 103906523; -. DR Proteomes; UP000053286; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 8. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053286}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFM13702.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053286}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 874 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001828684. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 98920 MW; 5ADE3A0096F3CE00 CRC64; MRILTGSLHF YFISFLFSRA NGFLTPRTPT AYAFPFYNYS YLNLSSVSEA QAPKTARALN FSHNVIEKIT KRDLEGFDTL EVLDLSYNQI KDIEPGAFER LLSLVSVNLS FNAKKLLVSG LPPHLKLLPT SEASGSLQLC RYFDGSPEAA LEPSASIEEL PHSGGPSVPQ NVNLRLRRST ENLLRRAEKN VTVSPTATLR PNFCGAPING ILDLSNSKLS EEELTLKLDP DLCQAQLDSI LELDISHSDL EMDLLSLFVL FLPMKNVQSI DASYNKLTIN ALDAEAICSF PFSKLLFLNI SNNPINSLDT LCLPSTIKVI DLSFTNISQI PQNFAKKMFN LENMYVQGNH FIYTVRPEIT NAVPKFPPGT VRINAISFVR NQAGTPIKSL PKKVKRLKMS NCSIVELPEW FADTVEELLF LDLSSNRISV LPDLPTSLKH LDISNSDIKI IPPNFKSVSN LTIFSIQNNK IVDMHPEYFP LTLTKCDISK NKLNTLSLTD ALEKLKYLNV SGNLITRLEP TSHLSALANL DSSHNLISEL PDHFGKSLPT LKYFNLSGNK ISFLQRGALP GSLVELDISD NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNTY IHNPHLQING KGNLRCSFPP DRRGSLVESS NLTLLRCSLG IQMAITACAA ILVVFLLTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEE KLFDAFVSYS EQDANWTKEN LLEKLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSVPQKFS KLRKLLKRKT YLKWSPEEHK QKVFWHQLAA VLKTTNEPLV RAENGSARDM YEME // ID A0A087V4T8_BALRE Unreviewed; 551 AA. AC A0A087V4T8; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFO07630.1}; DE Flags: Fragment; GN ORFNames=N312_04628 {ECO:0000313|EMBL:KFO07630.1}; OS Balearica regulorum gibbericeps (East African grey crowned-crane). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica. OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO07630.1, ECO:0000313|Proteomes:UP000053309}; RN [1] {ECO:0000313|EMBL:KFO07630.1, ECO:0000313|Proteomes:UP000053309} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO07630.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL479911; KFO07630.1; -; Genomic_DNA. DR Proteomes; UP000053309; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053309}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO07630.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053309}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001831200. FT TRANSMEM 348 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFO07630.1}. SQ SEQUENCE 551 AA; 63049 MW; 6609DB66878C25FB CRC64; MLTLFWILAL FVSGAEVREI NLPGCSHVEP QIWYRAISDE EFVLQCTLPD RDANHSYNNS LLKQHKVKWF WHQKGRESLK AIKESSNPAL QGDALWFKPV RDNASGVYIC MIWEKMPCLK IVLEVQTKVA AKCSGYDTNM LSLTAGKSNS ITCPGTKCYS HTKEPDVKWY KNGHQIKHRK SRPSLKLKHN EIYLNPTYAT DAGIYVCDYT LYDNTTKWTM RTVVTVEVIA KTTIHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFERVS LMRVTWKRNN KENINEKLSQ ETSVYPKSLK GHTLLHVAKL KEVTERDLRS NFTCFAENSV GNATAVIQLK RKQRAFRLYV LCSAISTLFA LLLCTAFIYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLDSSESD STLISEEKFA LELLPDMLEK KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YISGPSIFEL QAAVNCALED KKMKLVLIKF QAFQEPETLP PVVKKALRIL PVVTWKSSIS AAPNKKFWKY MHYHMPVKTT K // ID A0A087V8N9_BALRE Unreviewed; 874 AA. AC A0A087V8N9; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 28-FEB-2018, entry version 23. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFO08981.1}; GN ORFNames=N312_07178 {ECO:0000313|EMBL:KFO08981.1}; OS Balearica regulorum gibbericeps (East African grey crowned-crane). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica. OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO08981.1, ECO:0000313|Proteomes:UP000053309}; RN [1] {ECO:0000313|EMBL:KFO08981.1, ECO:0000313|Proteomes:UP000053309} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO08981.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL484033; KFO08981.1; -; Genomic_DNA. DR RefSeq; XP_010296814.1; XM_010298512.1. DR GeneID; 104632605; -. DR Proteomes; UP000053309; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053309}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO08981.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053309}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 874 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001831259. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 99130 MW; 40159D001C9FDB0B CRC64; MRILIGSLHF YFISFLFSRA NGFLTLRTPT AYAFPFYNYS YLNLSSVSEA QAPKTARALN FSHNVIEKIT KRDLEGFDVL EVLDLSYNQI KDIEPGAFES LLSLVSVNLS FNDKKLLVPG LPAHLKLSLA SEASGSLQLY KYFDRSPEAA SEPSAPAEEL PHAGRPSVLR NAHPRLRRST ENLLRRAEKN VTVSPTTTLR PNFCGVPING TLALSNSKLS EEELRLKLDP DVCQAQLDGI LELDISHNDL EMDLLLLFIL FLPMKNMQSV DASYNKLTIN IQDVEAICNF PFSNFLFLNI SNNPINSLDT LCLPSTIKVI DLSFTNISRI PPNFAKKMIN LENMYVQGNH FIYTVRPDVP NAVQMFPPGT VRINAISFVR DEGGTPIKSL PNKVKYLKMS NCSIVELPEW FAGTMGELLF LDLSSNRISV LPDLPTSLQH LDLSNSDIRA IPPSFKSVSN LTIFNIQNNK VTDMHPEHFP LTLTKCDISK NKLNTLSLTD ALEKLEYLNV SGNLIARLEP SSHLSALTNL DSSHNLISEL PDRFGKSLPT LRYFNLSGNK ISFLQRGSLP ASLIELDISN NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNVY IHHPRLQING KGSLKCSFPP ERRGSLVESS DLTLLRCSLG IQMAVTACVA ILVVLVLTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEN KPFDAFISYS EQDANWTKEN LLKKLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSQSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSVPQKFS KLRKLLKRKT YLKWSPEEHK QKMFWHQLAA VLKTTNEPLV RAENGSAQDM YEME // ID A0A087VHP3_BALRE Unreviewed; 437 AA. AC A0A087VHP3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFO12135.1}; DE Flags: Fragment; GN ORFNames=N312_12951 {ECO:0000313|EMBL:KFO12135.1}; OS Balearica regulorum gibbericeps (East African grey crowned-crane). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica. OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO12135.1, ECO:0000313|Proteomes:UP000053309}; RN [1] {ECO:0000313|EMBL:KFO12135.1, ECO:0000313|Proteomes:UP000053309} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO12135.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL493820; KFO12135.1; -; Genomic_DNA. DR Proteomes; UP000053309; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053309}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO12135.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053309}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO12135.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFO12135.1}. SQ SEQUENCE 437 AA; 49950 MW; 7EB0DD8AAB044C19 CRC64; PYLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLSDYHQA DSVQMRHYCR GYEYDVSAAT LPIASISNHH TYCNIPLTLL NGQLPLNNTM KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A087VMV3_BALRE Unreviewed; 437 AA. AC A0A087VMV3; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFO13945.1}; DE Flags: Fragment; GN ORFNames=N312_11490 {ECO:0000313|EMBL:KFO13945.1}; OS Balearica regulorum gibbericeps (East African grey crowned-crane). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica. OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO13945.1, ECO:0000313|Proteomes:UP000053309}; RN [1] {ECO:0000313|EMBL:KFO13945.1, ECO:0000313|Proteomes:UP000053309} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO13945.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL499147; KFO13945.1; -; Genomic_DNA. DR Proteomes; UP000053309; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053309}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO13945.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053309}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO13945.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFO13945.1}. SQ SEQUENCE 437 AA; 50277 MW; CB8540F08CB88A94 CRC64; GSSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091CNZ9_FUKDA Unreviewed; 1032 AA. AC A0A091CNZ9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFO19283.1}; GN ORFNames=H920_19328 {ECO:0000313|EMBL:KFO19283.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO19283.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO19283.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO19283.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KN125118; KFO19283.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFO19283.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 823 848 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 874 1019 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1032 AA; 119471 MW; AF14F96FE538D791 CRC64; MILISKLLEA RWFPKTLPCD ISLDPSKSHV LVDCTDKHLT EIPKGIPTNA TNLTLTINRI PNISPDSFHN LDHLVEVDFR CNCVPTRMGA KNNVCTRRLQ IKPRSFSRLT YLKALYLDAN QLLQIPQDLP PSLQLLSLEA NNIFFIMKKN LTELVNIEML YLGQNCYYRN PCNVSYSIEK NAFLNLRNLK VLSLKDNNIT AVPTLLPSNL TELYLYNNII TNIQKDDFNN LNHLQILDLS GNCPRCYNVP FPCTPCENNS ALQIHINAFD SLTELQVLRL HSNSLQHVPL EWFKHMSNLK ELDLSQNYLA KEIGDAKFLH FLPNLIQLDL SFNYELQVYH ASINLSHSFS SLKNLKILRI KGYVFKELKC LNLSPLHDLH NLEVLDLGTN FIKIADLSIF KQFQRLKLID LSMNKISPSG DSSETGFCSN SRTSAESNGP QVLETLHYFR YDEYARSCRV KNNESSFFAL NNDCYMYGQT LDLSRNNIFF VKPSDFQHLS FLKCLNLSGN AIGQTFNGSE FQHLEELKYL DFSNNRLDLL HSTAFEELHN LEILDLSSNS HYFQSEGITH MLNFTKNLKF LKKLMMNDND ISTSTSRTME SKSLKILEFR GNHLDILWRD GDNRYLKFFQ NLLNLEVLDI SRNSLSFLPP GVFEGMPPNL KNLSLAKNGL RTFNWGKLPF LKNLEFLDLS HNQLTTVPER LSNCSRTLRT LILMKNQIGH LTKYFLEDAF QLQYLDLSSN KIQVIQKTSF PQNVLNNLET LLLHHNRFLC NCDAIWFVWW VNHTDVTIPY LATEVTCAGP GAHKGQSVVS LDLYTCELNL INLILFSVSI SVALFLMVVM TASHLYFWDM WYIYHFCKAK IWGYQRLRSA ECCYDAFIVY DTKDPAVTEW VLDELVAILE DPREKHFNLC LEERDWLPGQ PVLENLSQSI QLSKKTVFVM TEKYAKTENF KIAFYLSHQR LMDEKIDVII LIFLEKPLMK SKFLQLRKRL CGSSVLEWPT NPQAHPYFWQ CLKNALAMDN HVVYSQMFKE TA // ID A0A091EBQ1_FUKDA Unreviewed; 1015 AA. AC A0A091EBQ1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 21. DE SubName: Full=Toll-like receptor 9 {ECO:0000313|EMBL:KFO32691.1}; GN ORFNames=H920_05860 {ECO:0000313|EMBL:KFO32691.1}; OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Fukomys. OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO32691.1, ECO:0000313|Proteomes:UP000028990}; RN [1] {ECO:0000313|EMBL:KFO32691.1, ECO:0000313|Proteomes:UP000028990} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Liver {ECO:0000313|EMBL:KFO32691.1}; RA Gladyshev V.N., Fang X.; RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of RT African mole rats."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KN122133; KFO32691.1; -; Genomic_DNA. DR Proteomes; UP000028990; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027181; TLR9. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24373:SF37; PTHR24373:SF37; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 16. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 17. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000028990}; KW Receptor {ECO:0000313|EMBL:KFO32691.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000028990}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 1015 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001873950. FT DOMAIN 851 999 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1015 AA; 113730 MW; C46635F6E8FAB074 CRC64; MQAVALAEAL ALGALPAFLP CELQPNGVVN CNWLFLKSVP RFSAAAPRSN VTSLSLLSNR IHHLHNSDFV HLPNLRHLNL KWNCPPTGLS PMHFPCHMTI EPKTFLAMPT LEDLNLSYNS ITTVPALPSS LVNLTLSHTN ILVLDSTSLT GLPALRILFM DGNCYYKNPC HQALEVAPGA LLGLGNLTHL SLKYNNLTTV PRDLPPSLEY LLLSYNHIFK LDPGDLANLT ALRVLDVGGN CRRCDHARNP CVECLNKTLQ LHPDTFHHLI HLEGLVLKDS SLHTLDPRWF RGLENLTVLD LSENFLYDCI TKTRAFQGLA RLHKLNLSFN YCKGVSFAHL QLAPSFGDLT SLQELDMNGI FFRSLSENTL KPLAHLPLLQ TLNLQMNFIN QAQLSIFGAF PALHFVDLSD NRISGAPTRT ALGEADDREE QVWLRPEDLA PAPLGNPKPR DFMPNCKHFP FTLDLSGNNL VTVKSEMFTN LSRLQCLILS HNCIAQAVNG SQFETLTSLQ VLDMSHNKLD LYHGHSFTEL PQLKALDLSY NSQPFGMQGI GHNLSFVARL HKLQYLSLAH NGINSRVNPR LYSRSLQVLD FSGNTVSSMW AEGDLYLHFF QGLQGLNLLD LSQNRLHTLL SRNLDSLPKS LKFLRLRDNY LAFFNWSSLI LLPKLQALDL AGNQLKGLTN GTLPNGTQLQ KLDVSGNSIS FVTPGFFALA TELQELNLSD NILSTIESSW FGTVAGNLKV LDVSANPLHC ICGAAFVDFL LEVQAAVPGL PNHVKCDSPI QLQGRSIFTQ DLRLCLDEAL SWDCFGLSLL VVALGLVVPV LQHLCGWDLW YCFHLGLTWL PRRGPRGAQA LPYDAFVIFD KTQGAVADWV YHELRVQLEE RRGRQALRLC LEERDWVPGK TLFENLWASV YGSRKTVFVL AHTDRVSGLL RTGFLLAQQR LLEDRKDIVV LVILSPDAHR SRYVRLRQRL CHQSVLFWPQ QPRGQGSFWA QLSTTLTRDN CYFYNRNFCQ GPAAE // ID A0A091EGK9_CORBR Unreviewed; 1026 AA. AC A0A091EGK9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFO55792.1}; DE Flags: Fragment; GN ORFNames=N302_01167 {ECO:0000313|EMBL:KFO55792.1}; OS Corvus brachyrhynchos (American crow). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae; OC Corvus. OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO55792.1, ECO:0000313|Proteomes:UP000052976}; RN [1] {ECO:0000313|EMBL:KFO55792.1, ECO:0000313|Proteomes:UP000052976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO55792.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK718327; KFO55792.1; -; Genomic_DNA. DR Proteomes; UP000052976; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 21. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052976}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFO55792.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052976}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 817 841 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO55792.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFO55792.1}. SQ SEQUENCE 1026 AA; 117515 MW; D0B423934D10D22D CRC64; LLSGAWFPKT LPCDVKSSEG TVTVDCTDRR LKEVPRGIPG NVTNLTLSIN HIPHIYPTSF DHLENLQEID FRCNCVPVKL GPKDNVCTSR LKIETGSFAA LTRLKSLYLD ANQLAEIPRG LPATLTLLSL EANSIFSIHE ASFSELGNIE VLYLGQNCYY RNPCNVSFEI EKTAFLGLKK LTILSLKSNN LTHIPPNLSS TLKELYIYNN MIQVIHEQDL SGLSNLEILD LSGNCPRCYN APYPCIPCPK SSIQIHSKAF DSLENLRILR LHSNSLQSIP SSWFKNIKNL KELDLSQNFL MREIGDAQFL TFIPSLMQLD LSFNFEVKVY SPFLNLSKTF SSLYNLETLR LKGYVFKELR AQDLRPLLGL QNLTMLDLGT NFIKVADLTV FEEFPALKFI DLSVNKISPS SGESNFYGFC SNPGISVEQY NRQVRQEMHY FRYDVYERSC RSKDKEASSY QSIVKEDCLN YGKTLDLSRN NIFFVNPSDF LGLSSLKCLN LSGNAISQTL NGSEFSYLSG LKYLDFSNNR VDLLHQTAFK ELKFLEILDL SNNQHYFLAE GITHVLSFMK NLAHLKKLMM NENEISTTID TGIESQSLRI LEFRGNRLDA LWKDGNARYL SFFKNLTSLE ELDISFNSLS FLPHDVFKGM PPSLKILNLT NNQLKSFIWG SLPSLRNLVT LDLSNNLLTT VPKELSNCTS SLQKLMLRNN RIQRLTKYFL RGAFKLRYLD LSSNKIEIIK RSSFPENVIN NLEMLLLHGN PFKCNCEAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGR SVVFLDLYTC QLDTSYLILY ALSASTVLGF MVFTVMSHLY FWDVWYSYHY CTAKLKGYRR LSLPEACYEA LIAYDNEDAA VNEWVLQELV ERLENQKARQ FNLCLEGRDW LPGQPVFDNL SQSIQLSKKT IFVLTNRYIK SGSFKTTFYM AHQRLLDDKM DVIILIFLEK VLQKSRYVRL RKRLCRSSVL EWPTNPQSQP YFWQCLKNAI ATSNSLAYNK LLQETV // ID A0A091ESD2_CORBR Unreviewed; 551 AA. AC A0A091ESD2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFO60783.1}; DE Flags: Fragment; GN ORFNames=N302_15260 {ECO:0000313|EMBL:KFO60783.1}; OS Corvus brachyrhynchos (American crow). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae; OC Corvus. OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO60783.1, ECO:0000313|Proteomes:UP000052976}; RN [1] {ECO:0000313|EMBL:KFO60783.1, ECO:0000313|Proteomes:UP000052976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO60783.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK718990; KFO60783.1; -; Genomic_DNA. DR Proteomes; UP000052976; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052976}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO60783.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052976}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001872825. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 112 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFO60783.1}. SQ SEQUENCE 551 AA; 62978 MW; FA8E3DC760001132 CRC64; MLTLCWILTL FVSGVEVREI NLPGCSHVEP QIWYRAINGE EFVLRCALPE RDATSIYNNS LLNQHKVEWF WHQKDKETLK AVKESSNLAF QGDALWFKPI RDSASGVYIC RMWGKIPCLE IVLDVQTKKA AKCSGYDTNM LYLLAGIGNS ITCPGTKCYS HIKKPDVKWY KDGHQVKHRK SRPSLKLKQN EIYLNPTYDK DAGIYVCDYT LPDNTTNWTV RTAVTVEVIA KNTIHPPNLL YPNGVVILEA ELGKPLELEC RVQFGFETVS PMRVTWKRSD EENINEKLNQ ETSVYPKGLK GSTLLHVATL KEVTEKDLRS NFTCFAENSV GNATAVIQLK RKQRVLFLYV LCSAISTLFA FVLCTAFIYQ HWIEIVLMYR SYLVHNKNTE DGKEFDAFVS YAKINSSESD SALISEEKFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRVIIVLSPA YVSGPSIFEL QAAVNCALED KRIKLVLIKF QDFQEPENLP PVVKKALRIL PIVTWKSSIS AAPHKKFWKY MHYHMPMKTM K // ID A0A091F1H8_CORBR Unreviewed; 434 AA. AC A0A091F1H8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFO55730.1}; DE Flags: Fragment; GN ORFNames=N302_01095 {ECO:0000313|EMBL:KFO55730.1}; OS Corvus brachyrhynchos (American crow). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae; OC Corvus. OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO55730.1, ECO:0000313|Proteomes:UP000052976}; RN [1] {ECO:0000313|EMBL:KFO55730.1, ECO:0000313|Proteomes:UP000052976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO55730.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK718327; KFO55730.1; -; Genomic_DNA. DR Proteomes; UP000052976; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052976}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO55730.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052976}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 141 300 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO55730.1}. FT NON_TER 434 434 {ECO:0000313|EMBL:KFO55730.1}. SQ SEQUENCE 434 AA; 49828 MW; C2E7ABA02031FABA CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDYDAYLSYT KVDPDQWNQE TGEEERFALE ILPDMLEKHY GYKLFIPDRD LIPTGTYIED VARCVDQSKR LIIVMTPSYV VRRGWSIFEL ETRLRNMLVT GEIKVILIEC SELRGVMNYQ EVEALKHTIK LLTVIKWHGP KCNKLNSKFW KRLQYEMPFK RIEPMTNEQV LDVSEQGPFG ELQTVSAISM AAATSTALAT AHPDLRSTFH NTYHSQMRQK HYYRSYEYDV PPAGTLPLTS IGNQHTYCNI PMTLINGQRP QTKTNREQNP EEAHTNSAIL PLLPRETSIS SVIW // ID A0A091FAB1_CORBR Unreviewed; 874 AA. AC A0A091FAB1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFO65484.1}; GN ORFNames=N302_14400 {ECO:0000313|EMBL:KFO65484.1}; OS Corvus brachyrhynchos (American crow). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae; OC Corvus. OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO65484.1, ECO:0000313|Proteomes:UP000052976}; RN [1] {ECO:0000313|EMBL:KFO65484.1, ECO:0000313|Proteomes:UP000052976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO65484.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK719746; KFO65484.1; -; Genomic_DNA. DR Proteomes; UP000052976; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052976}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Receptor {ECO:0000313|EMBL:KFO65484.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052976}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 874 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001873228. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 98294 MW; 650C44AD98952FE2 CRC64; MRILPGCLHF CFIPLLLSRA HGFLTWRTPP AFLVYNYSYS NLSSVSEAQA PKTARALNFS HNVIEKITKR DLERFARLEV LDLSYNRIRD VEPGAFQSLL SLVSVDLSFN YEKLLLSNLP PHLKLSPAGK APGSLQLSKN SDKSYGAALE PSVPTKELPR SGVLSLRQIL NPRLRRSTGN LLRRGEGNTV APPTATPEPS LCGIPINGTL DLSHSNLTTE ELMLKLDEDL CQAQLDRILE LDISHNNVEM DLLSLFGLFF PMENTLSIDA SSNKLTINIL DAESICEFPS HQLLFLNISN NPINSLDTLC LPSSIKEIDL SFTNISQIPV NFAKKLFNLE KMYVQGNHFI YTAFSESGNA LPTCVPPPGT VHISAISFVR NVAGTPIESL PEKVKHLGMS SCSIVELPEW FAETVEELLF LDLSSNYISV LPNFPSSLQH LDISNNDIEV IPPSLKSLSN LTIFMIQNNK IVAMHTEYFP SALKKCDFSK NKVKVLSLTD ALEKLEHLNI SGNLITHLEP AGRLPALTSW DSSHNLIPEL PDGFGESLPG LKYFNLSGNK ISFLQHGSLP ASLVELDISD NAITTIVEAT FGPLTSLRVL TVQGEHFFCT CDLYWFVNVY IHEPQLESRG RGAMTCSFPP ERRGSLVGSS RLTLLRCSLG VQLAVPPGAA SLAVLALAVL CWRLDGPWYI RMGWYWCMAK RKQYEKRPEN KLFDAFISYS EHDADWTKEN LLEKLENDGF RICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLNENLD SLIMIVLEDL PPHSVPQKFS KLRKLLRRKT YLKWSPEEHK QKIFWHQLKA VLKTTNEPLV RAENGSALEM QELE // ID A0A091FTX2_9AVES Unreviewed; 550 AA. AC A0A091FTX2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFO73970.1}; DE Flags: Fragment; GN ORFNames=N303_07472 {ECO:0000313|EMBL:KFO73970.1}; OS Cuculus canorus (common cuckoo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus. OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO73970.1, ECO:0000313|Proteomes:UP000053760}; RN [1] {ECO:0000313|EMBL:KFO73970.1, ECO:0000313|Proteomes:UP000053760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO73970.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL447476; KFO73970.1; -; Genomic_DNA. DR Proteomes; UP000053760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053760}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO73970.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053760}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 550 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5005414324. FT TRANSMEM 345 368 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 116 206 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 241 339 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 392 547 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 550 550 {ECO:0000313|EMBL:KFO73970.1}. SQ SEQUENCE 550 AA; 63375 MW; 71240D4F564E7991 CRC64; MFILCWILVL FVSQVEVIEN NVPGCSHVEP QIWYRAISDE EFVLQCALPD RDATHIYNSL LKQHRVKWFW HQKDKEPLRA IKQSSNPILQ GDALWFKPVT DNASGVYICV IREKIPCLKI ILDVQTKKEA KCLSYDANML YLLAGNGNSI TCPGTKCYSH TNKADVKWYK DGYQIKSRKS RQSLKLKRNE IYLNPTYDED AGIYMCDYTL YDNTTKWIVS FLVTVEVFAK NTIHPPNFLY PNGAVILEAE LGKPLQLECR VQFGFERLSL MRVTWKRNNK ENITELLNQE TRVYPKGLKG HTLLHIVKLK KVTERDLRSN FTCFAENSVG NATAVIRLKT KQKVFLLYIL CTAISALFAF FLCTAFIYHH WIEIVLMYRS YLVHNETTGD GKEFDAFVSY AKLDFSESDS TLISEEKFAL ELLPDMLENK YGYKLCILER DILPGGAYTD EVVTAIKQSR RAIIILSPAY VSGPSIFELQ AAVNCALEDK TIKLVLIKFQ TFQEPETLPP VVKKALRILP VVTWKSSISA TPNKKFWKYM HYHMPVKTTK // ID A0A091FU20_9AVES Unreviewed; 1026 AA. AC A0A091FU20; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFO72496.1}; DE Flags: Fragment; GN ORFNames=N303_05490 {ECO:0000313|EMBL:KFO72496.1}; OS Cuculus canorus (common cuckoo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus. OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO72496.1, ECO:0000313|Proteomes:UP000053760}; RN [1] {ECO:0000313|EMBL:KFO72496.1, ECO:0000313|Proteomes:UP000053760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO72496.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL447348; KFO72496.1; -; Genomic_DNA. DR Proteomes; UP000053760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053760}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFO72496.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053760}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 817 841 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO72496.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFO72496.1}. SQ SEQUENCE 1026 AA; 117641 MW; 9BBDD70D418A2477 CRC64; LLSGAWFPKS LPCDVKASEG TVAVDCTYRR LNDVPKGIPT NATNLTLSIN HIPHLYPTSF AHLKNLVEID FRCNCVPIRM GPKDHVCNTG PNIENGSFAV LPRLKSLYLD ANQLLEIPRG LPSTLSLLSL EANSIFSIQK ANLSELGNIE MLYLGQNCYY RNPCNVSFEI EKTAFLELKK LTILSLKSNN LTHVPPNLSS TLKELYIYNN MIQEIQEQDL SDLHNLEILD LSGNCPRCYN APYPCTPCPK SSIEIHAKAF HSLKNLRILR LHSNSLHTIP SSWFENIRNL KELDLSQNFL IKEIGDAQFL KFIPSLVELD LSFNFEPKMY PSCLNLSKTF SSLLNLETLR LRGYVFKELR EGNLGPLLNL RNLTVLDLGT NFIKIADLRM FQQFPALKFI DLSVNKISPS SGDTNSNGFC SNPRISLEQY NRQILQEMHY FRYDVYERSC RSKDKEAASY ESSVNEECLK YGETLDLSRN NVFFINPSDF EGLSSLRCLN LSGNAISQTL NGSEFSYLSG LKYLDFSNNR IDLLYPTAFE ELKLLEILDL SNNKHYFLAE GVTHMLSFMK DLTHLKKLMM NENEISTAAN TGMESHSLQI LEFRGNRLDI LWMDGNARYV SFFKNLTSLE QLDISFNSLS FIPPDVFKAM PPELKILNLT NNRMKSFHWG SLTYLKKLVT LDLSNNLLTA VPRELSNCSS TLEELMLRNN LIQHLSKHFL RGAFKLKYLD LSSNKIEMIK KSSFPENVIN NLRVLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGK SVVFLDLYTC ELDTSYLILY ALSLATLLGF MVFTVTSHLY FWDVWYSYHY CTAKLKGYQR LSSPDSCYDA FIAYDNEDPA VNEWVLTELV ERLENQKARR FNLCLEERDW LPGQPVFDNL SQSIQLSRKT IFVLTKKYIK SGSFKTTFYM AHQRLLDEKM DVIILIFLEK ALQKSRYVRL RKRLCRSSVL EWPTNPRSQP YFWQCLKNAV ATSSALAYNK LLQETV // ID A0A091G4I0_9AVES Unreviewed; 437 AA. AC A0A091G4I0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFO76281.1}; DE Flags: Fragment; GN ORFNames=N303_15576 {ECO:0000313|EMBL:KFO76281.1}; OS Cuculus canorus (common cuckoo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus. OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO76281.1, ECO:0000313|Proteomes:UP000053760}; RN [1] {ECO:0000313|EMBL:KFO76281.1, ECO:0000313|Proteomes:UP000053760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO76281.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL447694; KFO76281.1; -; Genomic_DNA. DR Proteomes; UP000053760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053760}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO76281.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053760}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO76281.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFO76281.1}. SQ SEQUENCE 437 AA; 50233 MW; 6A38D9C43B83082B CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTVYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091GEA5_9AVES Unreviewed; 1030 AA. AC A0A091GEA5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFO72497.1}; DE Flags: Fragment; GN ORFNames=N303_05491 {ECO:0000313|EMBL:KFO72497.1}; OS Cuculus canorus (common cuckoo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus. OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO72497.1, ECO:0000313|Proteomes:UP000053760}; RN [1] {ECO:0000313|EMBL:KFO72497.1, ECO:0000313|Proteomes:UP000053760} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO72497.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL447348; KFO72497.1; -; Genomic_DNA. DR Proteomes; UP000053760; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053760}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFO72497.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053760}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 821 845 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 870 1017 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO72497.1}. FT NON_TER 1030 1030 {ECO:0000313|EMBL:KFO72497.1}. SQ SEQUENCE 1030 AA; 118168 MW; 9941D75206C10A73 CRC64; LLSGAWFPKS LPCDVKASEG TVAVDCTYRR LNDVPKGIPT NATNLTLSIN HIPHLYPTSF AHLKNLVEID FRCNCVPVKL GPKDRVCNTR PNIENGSFVV LPRLKSLYLD ANQLLEIPRG LPSTLSLLSL EANSIFSIQK ANLSELGNIE MLYLGQNCYY RNPCNVSFEI EKTAFLELKK LTILSLKSNN LTHVPPNLSS TLKELYIYNN MIQEIQEQDL SDLHNLEILD LSGNCPRCYN APYPCTPCPK SSIEIHAKAF HSLKNLRILR LHSNSLHTIP SSWFENIRNL KELDLSQNFL IKEIGDEIVD AQFLKFIPSL VELDLSFNFE PKTYQPCLNL SKTFSSLSNL ETLRLRGYVF KELREGNLGP LLNLRNLTVL DLGTNFIKIA DLRMFQQFPA LKFIDLSVNK ISPSSGDTNS NGFCSNPRIS LEQYNRQILQ EMHYFRYDVY ERSCRSKDKE AASYESSVNE ECLKYGETLD LSRNNVFFIN PSDFEGLSSL RCLNLSGNAI SQTLNGSEFS YLSGLKYLDF SNNRIDLLYP TAFEELKLLE ILDLSNNKHY FLAEGVTHML SFMKDLTHLK KLMMNENEIS TAANTGMESH SLQILEFRGN RLDILWMDGN ARYVSFFKNL TSLEQLDISF NSLSFIPPDV FKAMPPELKI LNLTNNRMKS FHWGSLTYLK KLVTLDLSNN LLTAVPRELS NCSSTLEELM LRNNLIQHLS KHFLRGAFKL KYLDLSSNKI EMIKKSSFPE NVINNLRVLL LHGNPFKCNC DAVWFVWWIN QTQVTIPLLA TDVTCAGPGA HKGKSVVFLD LYTCELDTSY LILYALSLAT LLGFMVFTVT SHLYFWDVWY SYHYCTAKLK GYQRLSSPDS CYDAFIAYDN EDPAVNEWVL TELVERLENQ KARRFNLCLE ERDWLPGQPV FDNLSQSIQL SRKTIFVLTK KYIKSGSFKT TFYMAHQRLL DEKMDVIILI FLEKALQKSR YVRLRKRLCR SSVLEWPTNP RSQPYFWQCL KNAVATSSAL AYNKLLQETV // ID A0A091GXX8_BUCRH Unreviewed; 437 AA. AC A0A091GXX8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFO87397.1}; DE Flags: Fragment; GN ORFNames=N320_03283 {ECO:0000313|EMBL:KFO87397.1}; OS Buceros rhinoceros silvestris. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros. OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO87397.1, ECO:0000313|Proteomes:UP000054064}; RN [1] {ECO:0000313|EMBL:KFO87397.1, ECO:0000313|Proteomes:UP000054064} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO87397.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL514024; KFO87397.1; -; Genomic_DNA. DR Proteomes; UP000054064; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054064}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO87397.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054064}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO87397.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFO87397.1}. SQ SEQUENCE 437 AA; 50251 MW; A98449362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNTEEAHTNS AILPLLPRET SISSVIW // ID A0A091H6W2_BUCRH Unreviewed; 781 AA. AC A0A091H6W2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 19. DE SubName: Full=Toll-like receptor 4 {ECO:0000313|EMBL:KFO90517.1}; DE Flags: Fragment; GN ORFNames=N320_02858 {ECO:0000313|EMBL:KFO90517.1}; OS Buceros rhinoceros silvestris. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros. OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO90517.1, ECO:0000313|Proteomes:UP000054064}; RN [1] {ECO:0000313|EMBL:KFO90517.1, ECO:0000313|Proteomes:UP000054064} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO90517.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL524001; KFO90517.1; -; Genomic_DNA. DR Proteomes; UP000054064; Unassembled WGS sequence. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:InterPro. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0042116; P:macrophage activation; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054064}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO90517.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054064}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 587 606 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 630 769 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO90517.1}. FT NON_TER 781 781 {ECO:0000313|EMBL:KFO90517.1}. SQ SEQUENCE 781 AA; 89390 MW; E52A674D24598B29 CRC64; LPNTTQHLDL SFNNLRSLGS NAFSSLPELQ LLDLTRCHLH TIEDNSFKDL QNLSTLILTA NSLQFLGTAA FYGLTSLKKL VLVETNITSL TALPIGHLHT LQELHLGHNN ITSLKLPTYF NSLTSLRYLN FFSNKITYIS KGDLDTLREV NRFNLTLVLS LNNIKHIQPG SFEKIHLSEL ILRSSFENFS VMHTSLQGLN GLQVNRLIVG EFSDRQRLVN FQRGLLSGLC QVQMQEFVLI SFRNFDDDTD TLFNCIGNIS SIRLVDLRLE DVSEVPMFSQ VKQLECKKCK FKDVPAEKLS LFKELRVIRI TKSKHLTNFL QKFESLRNLE VIDLSENRLS FTSCCYQFRR CPNLTHLNLS FNSEISVTGD FTNVKNLLYL DFQHTKLTGP GSYPVFLSLQ KLIYLDISHT TTHVKSQCTF CGLNSLRVLK MAGNSFEDNK LANNLKNLSH LHTLDISSCK LEQVDQRSFD ALSELKELNI SNNKLLILDP VVYKPLRALI ALDFSRNQLS VLLESALEIL PDSLILLDIS QNLFDCSCVY LNFLKWIKEK QELLQNKELM ICHVPVYVKN VTLSRFDLSS CYPSPSAVVS SVIMVLAAVM CVFLIYKYYF QLYYSLVLLS GCKHSAERGD NYDAFVIHSS KDQEWVMKEL VEPLEGGTPP FRLCLYYRNF LPGVPIVTNI IQEGFLSSRN VIAVISADFL ESKWCSFEFD IAQSWQLVEG KAGIIMIVLG EVDKGLLRQR LGLSRYLRRN TYLEWKNKEI SKHIFWRQLT GVLLEGKKWN H // ID A0A091HDP9_BUCRH Unreviewed; 437 AA. AC A0A091HDP9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFO93589.1}; DE Flags: Fragment; GN ORFNames=N320_12854 {ECO:0000313|EMBL:KFO93589.1}; OS Buceros rhinoceros silvestris. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros. OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO93589.1, ECO:0000313|Proteomes:UP000054064}; RN [1] {ECO:0000313|EMBL:KFO93589.1, ECO:0000313|Proteomes:UP000054064} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO93589.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL533476; KFO93589.1; -; Genomic_DNA. DR Proteomes; UP000054064; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054064}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO93589.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054064}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO93589.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFO93589.1}. SQ SEQUENCE 437 AA; 49902 MW; 020B93DBD4DFB949 CRC64; PCLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQT DSVQMRHYCR GYEYDVSAAS LPIASISNHH TYCNIPLTVL NGQLPLNNPM KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A091HFW8_BUCRH Unreviewed; 870 AA. AC A0A091HFW8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFO93717.1}; GN ORFNames=N320_06816 {ECO:0000313|EMBL:KFO93717.1}; OS Buceros rhinoceros silvestris. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros. OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO93717.1, ECO:0000313|Proteomes:UP000054064}; RN [1] {ECO:0000313|EMBL:KFO93717.1, ECO:0000313|Proteomes:UP000054064} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO93717.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL533834; KFO93717.1; -; Genomic_DNA. DR RefSeq; XP_010140814.1; XM_010142512.1. DR GeneID; 104499056; -. DR Proteomes; UP000054064; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054064}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO93717.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054064}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 870 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001874378. FT TRANSMEM 655 678 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 707 851 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 870 AA; 98175 MW; E6E543A8097330A0 CRC64; MRILTGSLCF FFISFLFNST NGLPTLGTPT AYAFPFFNYS CLNLSSVAEA RAPKTARALN LSHNAIEKIT KRDLEGFDAL QVLDLSYNQI KDIEPGAFES LLSLVSVNLS FNHENLLVSG LPPHLELLPS SKASGSLQLS KYFDKSSEAA ASSEELPHWG GPLALQDVRP RLRRSTEGLL REGEKNGTPS PTATVRPDLC GVPINGILNL SHSKLSEEEL MLKLDSDLCQ AQLEGILELD ISHSDLEMDL LSLFVLFLPM KNMRSVDASH NKLTINVLDV GSICNFPFSQ LLFVNISHNP INSLDTLCLP STIKVIDLSF TNISRLPRIF ATRLPHVEQV YVQGNHFIYT AHQGGNNSLQ NCPLGVVCIS SISFVRNDAG TPIERLPSTV KQLKMSNCSI VELPEWFANT MNQLLVLDLS SNQISLLPDL PPSLQHLDIS NSDIEIIPPR FKSVSSLTVF NIQNNKVTDM HPEYFPLNLT KCDISKNKLK LLSLTDTLEN LEYLNVSGNL ITRLEPASHL SALTNLDSSH NLVSELPDHF GKSLPMLKYF NLSGNKISFL QRGSLPASLV ELDISDNAIT TIVEDTFGQL TSLSVLTVQG KHFFCNCDLY WFVNVYIHKP QLWINGKENL RCSFPPQRRG SLVARSNLTL LHCSLGIQMA ITACVATLVV LVLTGLCWRF DGLWYVRMGW YWCMAKRKQY EKRPENKLFD AFISYSEHDA NWTKENLLEK LERDGFKICY HERDFKPGHP ILGNIFYCIE NSHKVLFVLS PSFVNSCWCQ YELYFAEHRV LNENQDSLIM IVLEDLPPHS VPQKFSKLRK LLKRKTYLKW SPEEHKQKMF WRQLAAVLKT TNEPLLRAED GAAQEAYEME // ID A0A091HZ53_CALAN Unreviewed; 1026 AA. AC A0A091HZ53; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFP01579.1}; DE Flags: Fragment; GN ORFNames=N300_02353 {ECO:0000313|EMBL:KFP01579.1}; OS Calypte anna (Anna's hummingbird) (Archilochus anna). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Apodiformes; Trochilidae; Calypte. OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP01579.1, ECO:0000313|Proteomes:UP000054308}; RN [1] {ECO:0000313|EMBL:KFP01579.1, ECO:0000313|Proteomes:UP000054308} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP01579.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL218032; KFP01579.1; -; Genomic_DNA. DR Proteomes; UP000054308; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 21. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000054308}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFP01579.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054308}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP01579.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFP01579.1}. SQ SEQUENCE 1026 AA; 118269 MW; 313A05739F99D43A CRC64; LLSGVWFPKS LPCDVKASEG TVTVDCTDRR LLEVPKGIPA NVTNLTLSIN HIPHISPTSF SYLQNLMEID FRCNCVPVRM GPKDHVCTTI PRIENGSFSA LTSLKSLYLD ANRLPEIPQG LPISLSLLSL EANSIFSIQK VNFSELGNIE ALYLGQNCYY RNPCNVSFEI ENTAFLELKK LTILSLKSNN LTHIPPNLPS TLKELYIYNN MIQVIQEYDL SALQNLEILD LSGNCPRCYN APYPCTPCPK ITIQIHSKAF YSLKNLRILR LHSNSLQSIP SRWFKNIRNL KELDLSQNFL MKEIGDAQFL KSIPSLVMLD LSFNFELKMY PPSLNLSKTF SSLSNLETLR LKGYVFKELR EGNLDPLRRL RNLTVLDLGT NFIKIADLRV FKEFPSLKLI DLSVNKISPS SAESNFYGFC SNPRVSVEQY NRQLLQEMHY FRYDVYGRSC RSKDKEAAYY ESSVKEDCLK YGETLDLSRN NIFFINPSDF WGLSYLKCLN LSGNAISQTL NGSEFNYLSG LKYLDFSNNR IDLLYSTAFQ ELKLLEVLDL SYNKHYFLAE GVTHVLSFMK NLAYLQKLMM NENEISTSIS TGMESQSLRI LEFRGNRLDV LWKDGNPRYL SFFKNLTSLE QLDISFNSLS FFPSAVFQAL PPELKILNLT NNQMKSFNWG ALSYIKKLET LDLSNNLLTT VPRELSNCSS TLKELILRNN RIRKLTKYFL RDAFELKYLD LSSNELQIIK ESSFPENVIN NLKMLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGR SLVFLDLYTC ELDTSYLILY ALSASTILGL MMLTVTSHLY FWDMWYGYHY CTAKLRGYRR LSLPDACYDA FVAYDTEDPA VNEWVMKELV ERLENQEARQ FNLCLEQRDW LPGHPVFDNL SQSIQLSKKT IFVLTKKYIK SGSFRTTFYM AHQRLLDEKM DVIILIFLEK VLQKSRYVRL RMRLCRSSVL EWPTNPRSQP YFWHCLKNAI ATSNAQAYNK LLQETV // ID A0A091I0Y2_BUCRH Unreviewed; 383 AA. AC A0A091I0Y2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFO93103.1}; DE Flags: Fragment; GN ORFNames=N320_02762 {ECO:0000313|EMBL:KFO93103.1}; OS Buceros rhinoceros silvestris. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Bucerotiformes; Bucerotidae; Buceros. OX NCBI_TaxID=175836 {ECO:0000313|EMBL:KFO93103.1, ECO:0000313|Proteomes:UP000054064}; RN [1] {ECO:0000313|EMBL:KFO93103.1, ECO:0000313|Proteomes:UP000054064} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N320 {ECO:0000313|EMBL:KFO93103.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL531990; KFO93103.1; -; Genomic_DNA. DR Proteomes; UP000054064; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054064}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFO93103.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054064}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 178 204 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 68 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 225 380 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFO93103.1}. FT NON_TER 383 383 {ECO:0000313|EMBL:KFO93103.1}. SQ SEQUENCE 383 AA; 43948 MW; F09BE925CD9A2254 CRC64; FYQDGQQIKH MKSRQSLKLK HNEIYLNPTY DKDAGIYVCD YTLFDNTTKW TMRTLIAVEV IAKTTIHPPN LLYPNGVEIL EAELGKPLEL ECRVQFGFGR VSPMTVTWKR SNKENINEKL DEETSIYPKG LKGHTLLHVA KLKEVTEKDL RSNFTCFAEN LVGNATAVIQ LKRKQGVFLL YILCSAISTL FAFLLCTAFI YQYWIEIVLM YRSYLVHNET TGDGKEFDAF VSYAKLYSSE SDSTFMSEEK FALELLPDML ENKYGYKLCI LERDILPGGA YTDEVVTAIK QSRRTIIILS PAYISGPSIF ELQAAVNCAL EDKMIKLVLI KFQDFQEPET LPSAVKKALR ILPVITWKSS ISAAPNKKFW KYMRYHMPVK TPK // ID A0A091I9V8_CALAN Unreviewed; 507 AA. AC A0A091I9V8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 13. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFP04165.1}; DE Flags: Fragment; GN ORFNames=N300_03161 {ECO:0000313|EMBL:KFP04165.1}; OS Calypte anna (Anna's hummingbird) (Archilochus anna). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Apodiformes; Trochilidae; Calypte. OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP04165.1, ECO:0000313|Proteomes:UP000054308}; RN [1] {ECO:0000313|EMBL:KFP04165.1, ECO:0000313|Proteomes:UP000054308} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP04165.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL218306; KFP04165.1; -; Genomic_DNA. DR Proteomes; UP000054308; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054308}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP04165.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054308}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP04165.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFP04165.1}. SQ SEQUENCE 507 AA; 58727 MW; BB2B7B4F31FECCC7 CRC64; DGMEGEAFVI KCPKWSSSVQ VTWYHTDTNK IIPAEEEGSR IFSVNRFLWF LPTSREDSGN YTCVIRFSNN RTRSFNMSVQ IHPYKQGVCF PSQIRYPNDT GRGKIVCPTI DNYENATIIQ WYKDCKPLQG ERFFIGEKYI FIHNPRKEDN GYYTCQFNCT HKGNVFNVSA TRIFISKAKP SPLPPQILFP KNNDVIEVEV GAAFSLKCRA LLGIRKHPLA VVTWDVDNIP VKHLNTSRFR EKTDFFEGPE HGYYIETTLH ISEIKEEDLK ANFTCVALNK MQNTKATVTL KPKAQCEVGL PNIFLIIGLL VLLVVIAVSV ILYQSFRVDI VLLFREIFQP YSAKDDGKIY DAYVIYPQNH NSEANFVEYF VYQIMAEILE NKCGYKLCIY GRDIYPGEDT VSAIEKRMQK SRRLIILLTH QLINCEEPAY DQHIALYKAL IQKDIKVILL EIEKIGVYEQ LQESLRFIIK QQGTVKWKEQ HTGHPQSPSS KFWKQVRYHM PRTLKPA // ID A0A091IBC2_CALAN Unreviewed; 437 AA. AC A0A091IBC2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 13. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFP05874.1}; DE Flags: Fragment; GN ORFNames=N300_03927 {ECO:0000313|EMBL:KFP05874.1}; OS Calypte anna (Anna's hummingbird) (Archilochus anna). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Apodiformes; Trochilidae; Calypte. OX NCBI_TaxID=9244 {ECO:0000313|EMBL:KFP05874.1, ECO:0000313|Proteomes:UP000054308}; RN [1] {ECO:0000313|EMBL:KFP05874.1, ECO:0000313|Proteomes:UP000054308} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N300 {ECO:0000313|EMBL:KFP05874.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL218485; KFP05874.1; -; Genomic_DNA. DR Proteomes; UP000054308; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054308}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP05874.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054308}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP05874.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFP05874.1}. SQ SEQUENCE 437 AA; 50167 MW; 840EC59F0FF64D6A CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LITGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITN EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPAGTLP LTSIGNQHTY CNIPMTLING QRPQTKTSRE QNPEEAHTNS AVLPLLPRET SISSVIW // ID A0A091KHK2_9GRUI Unreviewed; 551 AA. AC A0A091KHK2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFP39552.1}; DE Flags: Fragment; GN ORFNames=N324_02279 {ECO:0000313|EMBL:KFP39552.1}; OS Chlamydotis macqueenii (Macqueen's bustard). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis. OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP39552.1, ECO:0000313|Proteomes:UP000053330}; RN [1] {ECO:0000313|EMBL:KFP39552.1, ECO:0000313|Proteomes:UP000053330} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP39552.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK743700; KFP39552.1; -; Genomic_DNA. DR Proteomes; UP000053330; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053330}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP39552.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053330}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001877497. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 207 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFP39552.1}. SQ SEQUENCE 551 AA; 63070 MW; 05234E44D4ECAA4E CRC64; MLTLCWILAL FVGGAEVRKI NLPGCSHVEP QIWYRAISDE EFFLQCTLPD RDATHIYDNS ILKQHEVKWF WHQKDKEPLK AIKGSSNPAL QGDALWFKPV RENASGVYIC MIREKIPCLK IVLEVQTKKA ANCSGYDTNM LYLLANSGNS ITCPGTKCYS QIKMPNVKWY KNGRQIKQSK SRQSLKLKQN EIYLNPTYKI DAGMYMCDYI LYDNTTKWTM RTVVTVEVIA KTTTHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFERVS LMNVTWKRNN NENINEKLNQ ETRVYSKGLK GHTLLHVAKL KEVTETDLRS SFTCFAENSV GNATAVIQLK RKQRVFFLYV LCSAISTLFA LLLCTVFIYQ HWIEIVLMYR SYLVHSETTG DGKEFDAFVS YAKLDSSESD STLISEEKFA LDLLPEMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YVNGPSIFEL QAAVNCALED KKIKVVLIKF QAFQEPETLP PVVKKALRIL PVVTWKSSIS AAPNKKFWKY MRYHMPVKTT K // ID A0A091KNR8_9GRUI Unreviewed; 440 AA. AC A0A091KNR8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFP41118.1}; DE Flags: Fragment; GN ORFNames=N324_12450 {ECO:0000313|EMBL:KFP41118.1}; OS Chlamydotis macqueenii (Macqueen's bustard). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis. OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP41118.1, ECO:0000313|Proteomes:UP000053330}; RN [1] {ECO:0000313|EMBL:KFP41118.1, ECO:0000313|Proteomes:UP000053330} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP41118.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK748821; KFP41118.1; -; Genomic_DNA. DR Proteomes; UP000053330; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053330}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP41118.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053330}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 98 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 94 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 147 306 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP41118.1}. FT NON_TER 440 440 {ECO:0000313|EMBL:KFP41118.1}. SQ SEQUENCE 440 AA; 50517 MW; CC6DFA25151E521A CRC64; VVTGGSANLT CRAFFGYSGD VSPLIYWMKG EKFIEDLDDS RVWESDIRVL KEHLGEQEVS ISLILDSVEE ADLGNYSCYV ENGNGRRHAS ILLHKRELMY TVELAGGLGA ILLLLVCLVT IYKCYKIEIM LFYRNHFGAE ELDGDNKDYD AYLSYTKVDP DQWNQETGEE ERFALEILPD MLEKHYGYKL FIPDRDLIPT GTYIEDVARC VDQSKRLIIV MTPNYVVRRG WSIFELETRL RNMLVTGEIK VILIECSELR GVMNYQEVEA LKHTIKLLTV IKWHGPKCNK LNSKFWKRLQ YEMPFKRIEP ITHEQVLDVS EQGPFGELQT VSAISMAAAT STALATAHPD LRSTFHNTYH SQMRQKHYYR SYEYDVPPAG TLPLTSIGNQ HTYCNIPMTL INGQRPQTKT NREQNPEEAH TNSAILPLLP RETSISSVIW // ID A0A091L186_9GRUI Unreviewed; 507 AA. AC A0A091L186; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFP45355.1}; DE Flags: Fragment; GN ORFNames=N324_01530 {ECO:0000313|EMBL:KFP45355.1}; OS Chlamydotis macqueenii (Macqueen's bustard). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Otididae; Chlamydotis. OX NCBI_TaxID=187382 {ECO:0000313|EMBL:KFP45355.1, ECO:0000313|Proteomes:UP000053330}; RN [1] {ECO:0000313|EMBL:KFP45355.1, ECO:0000313|Proteomes:UP000053330} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N324 {ECO:0000313|EMBL:KFP45355.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK762364; KFP45355.1; -; Genomic_DNA. DR Proteomes; UP000053330; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053330}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP45355.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053330}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 83 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP45355.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFP45355.1}. SQ SEQUENCE 507 AA; 58736 MW; E93CA4EE342ABCDD CRC64; DALEGEALVI KCPRWSSSVK VTWYHTNTNK IIPAEKEGSK MFSLDRFLWF LPTSTEDSGN YTCVIHFLNN RTKSFNMSVR VYPNKQGVCF PSQIRYPNDT GRGKIVCPTI DNYKNATIIQ WYKDCKPLQG ERYFKGEKYI FINNPGKEDD GYYTCKFIYT HKGNVYNVSA TRIFISKAKH SPLPPKILFP KDKDVIEVEL GAALSLKCQA RLGIKKQPIA VVTWDVDNIS VKNLDLPRFH EKTHFFEGRE QEYYKETTLH ITEVKKEDLQ ANFTCVAMNE MHNTKATVTM QLKAQCEVGL PNVLLIVGSL VLLFAIAASV ILYQSFRVDI VLLYREIFQP YSVKDDGKIY DAYVIYPRSH TNEASFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGEDT ASAIEKRMQK SRRLIILLTH QLINCKEPAY DQHIALYNAL IQNNMKVILL EMETIGTYEK LQESLRFIIQ QQGTVKWKEQ HTVHPQSTNS KFWKQVRYLM PLTLKSS // ID A0A091L9I5_CATAU Unreviewed; 874 AA. AC A0A091L9I5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 20. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFP51840.1}; GN ORFNames=N323_11756 {ECO:0000313|EMBL:KFP51840.1}; OS Cathartes aura (Turkey vulture) (Vultur aura). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Cathartidae; OC Cathartes. OX NCBI_TaxID=43455 {ECO:0000313|EMBL:KFP51840.1, ECO:0000313|Proteomes:UP000053745}; RN [1] {ECO:0000313|EMBL:KFP51840.1, ECO:0000313|Proteomes:UP000053745} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N323 {ECO:0000313|EMBL:KFP51840.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL304321; KFP51840.1; -; Genomic_DNA. DR Proteomes; UP000053745; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 8. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053745}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP51840.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053745}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 874 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001877971. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 98502 MW; BF90E7D9F007D699 CRC64; MRILIGSLHF YFLSLLFSRA NGFLTLRTPT AYAFPFYNYS YLNLSSVSEA QAPKTARALN FSHNVIEKIT KRDLEGFDTL EVLDLSYNQI KAIEPGAFES LLSLVSVNLS FNDKKLLVPG LPPHLKLLPT SKASGSLQLC RYFDKPSEAA LGPSASAEEL PHSGGPSVPQ KVNPRLRRST GNLLRGAEKN VTVSPTATLR PNFCEAPING ILDLSNSKLS EEELMLKLDP DLCQAQLDGI LELDISHSDL EMDLLSLFTL FLPMKNVQSI DASYNKLTIN ILDVEAICNF PFSKLLFLNI SNNPINSLDT LCLPSTIKVI DLSFTNISQI PQNFATKMLD LENMYVQGNH FIYTVRPEVT NAVPKFPPGT VHINAISFVR NQAGTPIESL PKKVKHLKMS NCSIVELPEW FAGTMEELLF LDLSSNRISV LPDLPTSLQH LDISNSDIKI IPPSFKSVSN LTTFNIQNNK ITDMHPEYFP LTLTKCDISK NKLNTLSLTD ALEKLESLNV SGNLITRLEP ASHLSALANL DGSHNLISEL PDHFGKSLPM LKYFNLSGNK ISFLQRGSLP ASLVELDISD NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNVY LHKPRLQING KGNLRCSFPP DRRGSLVASS NLTLLRCSLG IQMAITACVA ILVVLVLTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEN KPFDAFISYS EQDANWTKEN LLEKLESDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSVPQKFS KLRKLLKRKT YLKWSPEEHK QKMFWRQLAA VLKTTNEPLV RAENGSAQDT YEME // ID A0A091LA23_CATAU Unreviewed; 437 AA. AC A0A091LA23; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFP52697.1}; DE Flags: Fragment; GN ORFNames=N323_11384 {ECO:0000313|EMBL:KFP52697.1}; OS Cathartes aura (Turkey vulture) (Vultur aura). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Cathartidae; OC Cathartes. OX NCBI_TaxID=43455 {ECO:0000313|EMBL:KFP52697.1, ECO:0000313|Proteomes:UP000053745}; RN [1] {ECO:0000313|EMBL:KFP52697.1, ECO:0000313|Proteomes:UP000053745} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N323 {ECO:0000313|EMBL:KFP52697.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL308795; KFP52697.1; -; Genomic_DNA. DR Proteomes; UP000053745; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053745}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP52697.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053745}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP52697.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFP52697.1}. SQ SEQUENCE 437 AA; 49888 MW; E2907E6CAA3D0D09 CRC64; PSLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQA DSVQMRHYCR GYEYDVSAAT LPIASISNHH TYCNIPLTLL NGQLPLNNTM KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A091LD87_CATAU Unreviewed; 437 AA. AC A0A091LD87; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFP53248.1}; DE Flags: Fragment; GN ORFNames=N323_09379 {ECO:0000313|EMBL:KFP53248.1}; OS Cathartes aura (Turkey vulture) (Vultur aura). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Cathartidae; OC Cathartes. OX NCBI_TaxID=43455 {ECO:0000313|EMBL:KFP53248.1, ECO:0000313|Proteomes:UP000053745}; RN [1] {ECO:0000313|EMBL:KFP53248.1, ECO:0000313|Proteomes:UP000053745} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N323 {ECO:0000313|EMBL:KFP53248.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL311826; KFP53248.1; -; Genomic_DNA. DR Proteomes; UP000053745; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053745}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP53248.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053745}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP53248.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFP53248.1}. SQ SEQUENCE 437 AA; 50261 MW; 4BCE52E07C879F28 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRILKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091M900_CARIC Unreviewed; 874 AA. AC A0A091M900; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 21. DE SubName: Full=Toll-like receptor 2 {ECO:0000313|EMBL:KFP67946.1}; GN ORFNames=N322_02178 {ECO:0000313|EMBL:KFP67946.1}; OS Cariama cristata (Red-legged seriema). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Cariamiformes; Cariamidae; Cariama. OX NCBI_TaxID=54380 {ECO:0000313|EMBL:KFP67946.1, ECO:0000313|Proteomes:UP000054116}; RN [1] {ECO:0000313|EMBL:KFP67946.1, ECO:0000313|Proteomes:UP000054116} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N322 {ECO:0000313|EMBL:KFP67946.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK525423; KFP67946.1; -; Genomic_DNA. DR RefSeq; XP_009704397.1; XM_009706095.1. DR GeneID; 104166232; -. DR Proteomes; UP000054116; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054116}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP67946.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054116}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 874 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001878490. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 99031 MW; 025849D9FCFF3EF2 CRC64; MRILIGSLHF YFISFLFSRA NGFLTLRTPT AYAFPFYNYS YLNLSSVSEA QAPKLARALN FSHNIIEKIT KRDLEGFDAL EVLDLSYNQI KDIEPGAFES LLSLVSVNLS FNDKKLLVSS LPPHLKLLPT SKASGSLQLY KYFDKSLEAA LEPSASAEEL PHSGGPSVLQ NVNPRLRRST GNLLRRAEKN VTVTPTATLR PNFCGAPING ILDLSNSKLS EEELTFKLDP DLCQAQLDGI LELNISHSDL EMDLLSLFVL FLPMKNVQSI DASYNKLTIN ILDVEAICNF PFSKLLFLNI SNNPINNLDT LCLPPTIKVI DLSFTNISQI PQNFAKKMLN LENMYVQGNH FIYTVRPEDT NAAPKLPPGT VRINAISFVR NQAGTPIESL PKTVKHLKMS NCSIVELPEW FAGTMKELLF LDLSSNRISV LPDLPTSLQH LDISNSDIKI IPSSFKSFSN LTIFNIQNNK ITDMHPEYFP LALTKCDISK NKLSVLSLTD ALEKLEFLNV SGNLITRLEP TSHLSALANL DSSHNLISEL PDHFGKSLPM LKYFNLSGNK ISFLQHGSLP ASLIELDISD NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNAY IHNPRLQING KGDLRCSFPP DRRGWLVESS NLTLLRCSLG IQMAVTACVA ILVVLVLTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEN KPFDAFISYS EYDANWTKEN LLEKLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVI FVLSPSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSLPQKFS KLRKLLKRKT YLKWSPEEHK QKMFWHQLAA VLKTTNEPLV RAENGSAQDI YEMK // ID A0A091NGQ4_9PASS Unreviewed; 507 AA. AC A0A091NGQ4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFP88953.1}; DE Flags: Fragment; GN ORFNames=N310_13921 {ECO:0000313|EMBL:KFP88953.1}; OS Acanthisitta chloris (rifleman). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Acanthisittidae; OC Acanthisitta. OX NCBI_TaxID=57068 {ECO:0000313|EMBL:KFP88953.1, ECO:0000313|Proteomes:UP000053537}; RN [1] {ECO:0000313|EMBL:KFP88953.1, ECO:0000313|Proteomes:UP000053537} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N310 {ECO:0000313|EMBL:KFP88953.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK847683; KFP88953.1; -; Genomic_DNA. DR Proteomes; UP000053537; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053537}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP88953.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053537}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 326 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 287 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP88953.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFP88953.1}. SQ SEQUENCE 507 AA; 59131 MW; 31D9744C92773D35 CRC64; DAMEGEALVI KCPQRSSSVK ITWYHMDNNK IIPAEEEGSR VFSLGRFLWF LPTSREDSGN YTCVTHLSNN RTKMFNTSVQ VHPYKQGTCF PSQIRYPNDT GRGKVVCPTI DNYKNATVIQ WYKDCKPLQG QRYLKEEKYI YIENPGREDD GYYTCRFIYT HKGKVFNVSA TRIFISQAKP SPLAPQILFP KNKEVIEVEL GAALSLKCQA RLGIKKQPVA VVTWDVDNIP VKYFNFPRFH EETTFFEGRE HVYYRETTLH ITEVKQEDLQ SNFTCIALNI MHNTRVTVTL QPKAQRDVVL PNVLLITGSL VLLVAIAVSV IFYQFFRVDI VLLYREIFRP YSVKDDGKIY DAYVIYPKNH TNEANFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGEDT ASAIEKRIQK SRRLIILLTH QLINCKEHAY DQHIALYNTL IQNDTKVILL EMETLGTYEK LQESLRFIIQ QQGTIKWKEQ HTVHPQSSNS KFWKQVRYHM PRTLKSS // ID A0A091NII9_APAVI Unreviewed; 437 AA. AC A0A091NII9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFP89583.1}; DE Flags: Fragment; GN ORFNames=N311_11696 {ECO:0000313|EMBL:KFP89583.1}; OS Apaloderma vittatum (Bar-tailed trogon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Trogoniformes; Trogonidae; OC Apaloderma. OX NCBI_TaxID=57397 {ECO:0000313|EMBL:KFP89583.1, ECO:0000313|Proteomes:UP000054244}; RN [1] {ECO:0000313|EMBL:KFP89583.1, ECO:0000313|Proteomes:UP000054244} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N311 {ECO:0000313|EMBL:KFP89583.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL385007; KFP89583.1; -; Genomic_DNA. DR Proteomes; UP000054244; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054244}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFP89583.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054244}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFP89583.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFP89583.1}. SQ SEQUENCE 437 AA; 50233 MW; AF0F09262E600605 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPISH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091PGT5_LEPDC Unreviewed; 437 AA. AC A0A091PGT5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFQ06885.1}; DE Flags: Fragment; GN ORFNames=N330_12984 {ECO:0000313|EMBL:KFQ06885.1}; OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; OC Leptosomus. OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ06885.1, ECO:0000313|Proteomes:UP000053001}; RN [1] {ECO:0000313|EMBL:KFQ06885.1, ECO:0000313|Proteomes:UP000053001} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ06885.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK673395; KFQ06885.1; -; Genomic_DNA. DR PhylomeDB; A0A091PGT5; -. DR Proteomes; UP000053001; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053001}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ06885.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053001}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ06885.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFQ06885.1}. SQ SEQUENCE 437 AA; 50263 MW; 8E9540F08CB88DE4 CRC64; GSSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091PSN8_HALAL Unreviewed; 551 AA. AC A0A091PSN8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFQ10273.1}; DE Flags: Fragment; GN ORFNames=N329_07323 {ECO:0000313|EMBL:KFQ10273.1}; OS Haliaeetus albicilla (White-tailed sea-eagle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Falconiformes; Accipitridae; OC Accipitrinae; Haliaeetus. OX NCBI_TaxID=8969 {ECO:0000313|EMBL:KFQ10273.1, ECO:0000313|Proteomes:UP000054379}; RN [1] {ECO:0000313|EMBL:KFQ10273.1, ECO:0000313|Proteomes:UP000054379} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N329 {ECO:0000313|EMBL:KFQ10273.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK664369; KFQ10273.1; -; Genomic_DNA. DR Proteomes; UP000054379; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054379}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ10273.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054379}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001877998. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 236 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFQ10273.1}. SQ SEQUENCE 551 AA; 63207 MW; 243E377325644EF0 CRC64; MLTLCWILAL FVSVAELREI YLPGCSHVEP QIWYRAISDE EFVLQCALPD RDATHIYNNS LLKQHQVEWF WHQKGKEPLK AIKGSSNPAL QGDALWFKPV RDNASGVYIC MIREKIPCLK IVLEVQTKKV AKCSGYDTNM LYLLAANGNS ITCPGTKCYS HVKKTDVKWY KDGHQIKHRK SRQSLKLKPN EIYLNPTYDR DAGVYVCDYT LYDNTTKWTM RTAVTVEVIE KNTIHPPNFL YPNGVVTLEA ELGKPLELEC RVQFGFERIS LMRVTWKRNN KENINEKLNQ ETSIYSKGLK GHTLLHVAKL KEVTERDLRS NFTCFAENSV GNATAVIQLK RKQRVFLLYV LCSAISILFA FLLCTAFIYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLDSSEGD STLISEEKFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YVSGPSIFEL QAAVNCALED KRIKLVLIKF QAFQEPETLP PVVKKALRIL PVITWKTSIS AAPNKKFWKY MHYHMPVKTT K // ID A0A091Q3H6_LEPDC Unreviewed; 437 AA. AC A0A091Q3H6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFQ14762.1}; DE Flags: Fragment; GN ORFNames=N330_08255 {ECO:0000313|EMBL:KFQ14762.1}; OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; OC Leptosomus. OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ14762.1, ECO:0000313|Proteomes:UP000053001}; RN [1] {ECO:0000313|EMBL:KFQ14762.1, ECO:0000313|Proteomes:UP000053001} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ14762.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK686417; KFQ14762.1; -; Genomic_DNA. DR PhylomeDB; A0A091Q3H6; -. DR Proteomes; UP000053001; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053001}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ14762.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053001}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ14762.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFQ14762.1}. SQ SEQUENCE 437 AA; 49759 MW; 9C3C8CC684B4200C CRC64; PSLFFLSSGS PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNCH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQA DSVQMRHYCR GYEYDVSAAT LPIASISNHH TYCNIPLTLL NGQLPLNNTV KDSQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A091Q4V7_LEPDC Unreviewed; 502 AA. AC A0A091Q4V7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 14. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFQ15237.1}; DE Flags: Fragment; GN ORFNames=N330_13940 {ECO:0000313|EMBL:KFQ15237.1}; OS Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Coraciiformes; Leptosomidae; OC Leptosomus. OX NCBI_TaxID=188344 {ECO:0000313|EMBL:KFQ15237.1, ECO:0000313|Proteomes:UP000053001}; RN [1] {ECO:0000313|EMBL:KFQ15237.1, ECO:0000313|Proteomes:UP000053001} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N330 {ECO:0000313|EMBL:KFQ15237.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK687631; KFQ15237.1; -; Genomic_DNA. DR PhylomeDB; A0A091Q4V7; -. DR Proteomes; UP000053001; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053001}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ15237.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053001}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 502 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ15237.1}. FT NON_TER 502 502 {ECO:0000313|EMBL:KFQ15237.1}. SQ SEQUENCE 502 AA; 58516 MW; A55C4F8042E9E51D CRC64; DAMEGEAFVI KCPRWSSAVK FTWYHTHTKK IIPAEEERSR VFSFKRFLWF LPTSREDSGN YTCDIHFSNN STKSFNMSVQ VHPYKQGVCF PSQIRYPNDT GRGKIVCPTI DNYTNATIIQ WYKNCKPLQG QRYFKAEKYI FINNPRKEDD GYYTCRFIYT HKGNVFNVSA TRIFISKAKH SPLPPQILFP KDKSVVEVEL GAPLALKCQA RLGIKKQPIA VVTWDVDNIP VKSLDFSRFH EKNHFFEGHE QEHYRETTLH VTEIRKEDLQ ANFTCVAVNE MHNTKATVTL QLKAQCEVGL PNILLIIGSL ILLLAIAVSV ILYQSFRVDI VLLYREIFQP YSVKDDGKIY DAYVIYPKSH TNEANFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGEDT ASAIEKRMQK SRRLIIVLTR QLINCKEQAY DQHIALYNAL IQNDTKVILL EMETIGTYEK LQESLRFVIK QQGTIKWKKQ HTVLSQSSNS KFWKQVRYHM PL // ID A0A091QMF7_MERNU Unreviewed; 437 AA. AC A0A091QMF7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFQ27796.1}; DE Flags: Fragment; GN ORFNames=N331_11878 {ECO:0000313|EMBL:KFQ27796.1}; OS Merops nubicus (Northern carmine bee-eater). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops. OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ27796.1, ECO:0000313|Proteomes:UP000052967}; RN [1] {ECO:0000313|EMBL:KFQ27796.1, ECO:0000313|Proteomes:UP000052967} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ27796.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK701866; KFQ27796.1; -; Genomic_DNA. DR Proteomes; UP000052967; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052967}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ27796.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052967}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ27796.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFQ27796.1}. SQ SEQUENCE 437 AA; 50249 MW; B839770CC55503DD CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDMRILKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPAGTLP LTSLGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS ALLPLLPRET SISSVIW // ID A0A091QRC3_9GRUI Unreviewed; 551 AA. AC A0A091QRC3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFQ30115.1}; DE Flags: Fragment; GN ORFNames=N332_01788 {ECO:0000313|EMBL:KFQ30115.1}; OS Mesitornis unicolor (brown roatelo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; OC Mesitornis. OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ30115.1, ECO:0000313|Proteomes:UP000053369}; RN [1] {ECO:0000313|EMBL:KFQ30115.1, ECO:0000313|Proteomes:UP000053369} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ30115.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK802968; KFQ30115.1; -; Genomic_DNA. DR Proteomes; UP000053369; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053369}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ30115.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053369}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001878571. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 112 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFQ30115.1}. SQ SEQUENCE 551 AA; 62948 MW; B693AE8C81591B8F CRC64; MLTLCWILAL FVSVTEVREI NLPGCSHVEP QIRYRAISDE EFVLQCALPG RDTTHIYKNS LLKQHKVKWF WHQKGQEPLK AIKESSNLVL QGDALRFKPV RDSDSGVYIC VIWEEVPCLK IVLEVQTKAA AKCSGYDKNT LYLLAGTGNS ITCPGTKCFS HIIKPDVKWY KDGHQIKHRK SRQSLKLKHN EIYLNPTYDK DAGTYVCDYT LYDNTTKWTM RTAVTVEVIA KNTIHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFENVS SLRITWKRKN KENINEKLNQ ETSVCTKGLK GYTLLHVAKL KEVTERDLRS NFTCFAENSV GNATAVIQLK RKQRVFLLYV LYSAISTLFA FLLCTALIYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLDSAESD STLISEEKFA LEILPDMLEN KYGYKLCILE RDVLPGGAYT DEVVTAIKQS RRTIIILSPA YISGPSMFEL QAAVNCALED KKIKLVLIKF QAFQEPETLP PVVKKALRIL PVITWKSSIS AAPNKKFWKY MHYHMPAKTT K // ID A0A091R4P7_9GRUI Unreviewed; 873 AA. AC A0A091R4P7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 16. DE SubName: Full=Toll-like receptor 2 {ECO:0000313|EMBL:KFQ34219.1}; DE Flags: Fragment; GN ORFNames=N332_08007 {ECO:0000313|EMBL:KFQ34219.1}; OS Mesitornis unicolor (brown roatelo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Mesitornithidae; OC Mesitornis. OX NCBI_TaxID=54374 {ECO:0000313|EMBL:KFQ34219.1, ECO:0000313|Proteomes:UP000053369}; RN [1] {ECO:0000313|EMBL:KFQ34219.1, ECO:0000313|Proteomes:UP000053369} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N332 {ECO:0000313|EMBL:KFQ34219.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK809053; KFQ34219.1; -; Genomic_DNA. DR Proteomes; UP000053369; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 12. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053369}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ34219.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053369}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 873 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001880350. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 873 873 {ECO:0000313|EMBL:KFQ34219.1}. SQ SEQUENCE 873 AA; 98525 MW; 0439D61731DC8379 CRC64; MKILIGSLHF YFMSVLFSRA NGSLTLRTPS AYAFPFCNYT YLNLSSVSEA QAPKTARALN FSHNVIEKIT KRDLEGFDVL EVLDLSYNQI KDIEPGAFER LFSLVSVNLS FNDKKLLVPG LPPHPKLLPP SQASGSLQLY TYFDKSSEAA PEPSASAKEL PHLGGPSVLQ NVNARLRRNT ENLLRRAEKN TTASPAATSR PDFCGAPVNG TLDLSNSKLS EEELSAKLDA NLCQVQLEGI VELNISHSDL EMDLLSLFIL FLPMENVQSI DASYNKLTIN IQDVEAICNF PLSKLSFLNI SNNPINSLDT LCLPSTIQII DLSFTNISQI PPNFARKMMN LEHMYVQGNH FIYTVRPQIT NAVAKPPPGT VHINAISFVR NLNGTPIESL PNKLKHLKMS NCSIVELPEW FVGTMQELLF LDLSSNRISV LPDLPTSLQH LDISNSDIKI IPPSFKSVSN LTIFNIQNNK ITDMHPEYFP LTLTKCDISK NKLNTLSLTD ALGKLEHLNV SGNLITRLEP ASYLSALANL DSSRNLISEL PDHFGKALPM LKYFNLSGNK ISFLQRGSLP ASLIELDISD NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNVY MHHPHLRING KGNLRCSFPP DRRGSLVESS RLTLLHCSLG IQMAITACVA VLVVLVLTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEN KPFDAFVSYS EQDANWTKEH LLERLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSVPQKFS KLRKLLKRKT YLKWSPEEHK QKMFWHQLAA VLKTTNEPLV KAESGCALDM HEM // ID A0A091R5T5_MERNU Unreviewed; 502 AA. AC A0A091R5T5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFQ34607.1}; DE Flags: Fragment; GN ORFNames=N331_10486 {ECO:0000313|EMBL:KFQ34607.1}; OS Merops nubicus (Northern carmine bee-eater). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Coraciiformes; Meropidae; Merops. OX NCBI_TaxID=57421 {ECO:0000313|EMBL:KFQ34607.1, ECO:0000313|Proteomes:UP000052967}; RN [1] {ECO:0000313|EMBL:KFQ34607.1, ECO:0000313|Proteomes:UP000052967} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N331 {ECO:0000313|EMBL:KFQ34607.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK713144; KFQ34607.1; -; Genomic_DNA. DR Proteomes; UP000052967; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 2. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052967}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ34607.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052967}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 502 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ34607.1}. FT NON_TER 502 502 {ECO:0000313|EMBL:KFQ34607.1}. SQ SEQUENCE 502 AA; 58299 MW; 4ABA7C27712A082F CRC64; DAMEGEALVI KCPRWSSAVK VTWYHTATNR TIPAEEEGSR IFSFNQFLWF LPTSREDSGN YTCVIHFSNN RTKPFNMSVQ VHPYKQGVCF PSQIRYPNDT GRGKIVCPTI DNYKNATIVQ WYKDCKILQG QRYFKGEKYI FINNPRKEDD GYYTCQFIYT HKGNVFNVSA TRIFISKAKH SPLPPQILFP KDKDAIEVEL GAALSMKCRA RLGIKKQAIA VVTWDVDNIP VKELNSSRFH EKNYFFEGRE QEYYREATLH ISEIKKEDLQ ANFTCVALNE MHNTRATVTL KLKAPCEVGL PNVLLVAGSL VLLVAIAVSV ILYQSFRIDI ILLYREMFQP YSVKDDGKIY DAYVIYPKCH TNEANFVEYF VYQVMPDILE NKCGYKLCIY GRDIYPGEDT ASAIEKRMQK SRRLIILLTH QLINCKELAY DQHIALYNAL IQNDTKVILL EMETIGTYEK LQESLRFIIK RQGTVKWKEQ HTVHPQSPSS KFWKQVRYHM PL // ID A0A091RRA7_NESNO Unreviewed; 1026 AA. AC A0A091RRA7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFQ44639.1}; DE Flags: Fragment; GN ORFNames=N333_02444 {ECO:0000313|EMBL:KFQ44639.1}; OS Nestor notabilis (Kea). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor. OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ44639.1, ECO:0000313|Proteomes:UP000053840}; RN [1] {ECO:0000313|EMBL:KFQ44639.1, ECO:0000313|Proteomes:UP000053840} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ44639.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK929875; KFQ44639.1; -; Genomic_DNA. DR Proteomes; UP000053840; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053840}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFQ44639.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053840}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 817 841 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ44639.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFQ44639.1}. SQ SEQUENCE 1026 AA; 117738 MW; 14796567BA0C1817 CRC64; LLSGTWFPRS LPCDVNTFEG TVTVDCTDRR LLEVPRGIPA NATNLTLSIN HIPHINPTSF AHLVNLVEID FRCNCVPLKM GPKDNVCNRQ PKIENGSFAA LTKLKSLYLD ANQLSEIPRG LPATLSLLSL EANHIFSIQK ANLSVLGNIE VLYLGQNCYY RNPCNVSFEI EKTAFLELKK LTILSLKSNN LTHIPPNLSS TLKELYIYNN KIQVIQEHDL SALHNLEILD LSGNCPRCYN APYPCTPCPK STIEIHSKAF YSLKNLRILR LHSNSIQSIP SSWFKNIRNL KKLDLSQNFL IKEIGDAQFL KFIPSLVELD LSFNFELKMY SPSLNLSKSF SSLSNLETLR LRGYVFKELR EGNLAPLFSL RNLTILDLGT NFIKVADLSV FKKFPALKLV DLSVNKISPS SGESNFYGFC SNPRISVEQY NRQVLEEMHY FRYDEYGRSC RSKDKEAASY QSSVKKDCLE YGETLDLSRN NIFFINPSDF QGLSYLRCLN LSGNAISQTL NGSEFSYLSG LKYLDFSNNR IDLLYSTAFK ELKLLEILDL SNNKHYFLAE GVSHMLSFMK NLAHLKKLMM NENEISTSIN TGMESQSLQI LEFRGNRLDV LWMDGNARYL SFFKNLTSLE ELDISFNSLS FLPHGVFEAM PPELKILNLT NNQMKSFNWE NLRYLKKLET LDLSNNLLVT VPQELSNCSS TVQKLILRNN HIHQLTKHFL RGAFKLKYLD LSSNKIQIIK KSSFPENVIN NLKTLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGK SVVFLDLYTC ELDTSYLILY ALSASAVLGF MVFTVMSHLY FWDVWYSYHY CTAKLKGYRH LPLPDACYDA FIAYDNEDPA VNEWVMEELV ERLEDQRARQ FNLCLEGRDW LPGQPVFDNL SQSIQLSKKT IFVLTNKYIK SGNFKTTFYM AHQRLLDEKI DVIILIFLEK VLQKSRYVQL RKRLCRSSVL EWPTNPRSQP YFWQCLKNAI AMNNTLAYNK LLQETV // ID A0A091S0C1_NESNO Unreviewed; 550 AA. AC A0A091S0C1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFQ48288.1}; DE Flags: Fragment; GN ORFNames=N333_03281 {ECO:0000313|EMBL:KFQ48288.1}; OS Nestor notabilis (Kea). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Nestor. OX NCBI_TaxID=176057 {ECO:0000313|EMBL:KFQ48288.1, ECO:0000313|Proteomes:UP000053840}; RN [1] {ECO:0000313|EMBL:KFQ48288.1, ECO:0000313|Proteomes:UP000053840} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N333 {ECO:0000313|EMBL:KFQ48288.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK937840; KFQ48288.1; -; Genomic_DNA. DR Proteomes; UP000053840; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053840}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ48288.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053840}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 550 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001879614. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 547 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 550 550 {ECO:0000313|EMBL:KFQ48288.1}. SQ SEQUENCE 550 AA; 62707 MW; EE0C2741ACAD4BA0 CRC64; MLTFCWILAL FVNGAEVRET NLLGCSHVEP QIWYRAISGE EFVLQCALPD RDATHIYNNN SLLKQHKVKW FWQKDKEPLK AIKESSNPAL QGDALWFKPV RDSDSGVFIC VIWEKIPCLK IVLEVQTKKV AKCSAYDTNT VYLRAGNGNS IICPGTKCYS HIKKTDVKWY KDGHQIKHRK TRKSLKLKHN EIHLNPTYDK DAGIYVCDYV LYDNTTKWTM RTTVTVEVIA KNTIHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFERSS LRRVTWKRNN KENINEKLSQ ETSVYPAGLK GHTLLHVAKL KEVTERDLGS NFTCFAENSV GNATAVIQLK RKQRVFLLHV LCSAISILFA LLLCAAFVYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLDSSESN STLISEAKFA LELLPDMLET KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YVSGPSIFEL QAAVNCALED KKIKLVLIKF QAFQEPETLP PVVKKALRIL PVITWKSSVS GAPNKFWKYM RYHMPVKSTK // ID A0A091SHF7_9AVES Unreviewed; 437 AA. AC A0A091SHF7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFQ58062.1}; DE Flags: Fragment; GN ORFNames=N334_03671 {ECO:0000313|EMBL:KFQ58062.1}; OS Pelecanus crispus (Dalmatian pelican). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Pelecanidae; OC Pelecanus. OX NCBI_TaxID=36300 {ECO:0000313|EMBL:KFQ58062.1, ECO:0000313|Proteomes:UP000054150}; RN [1] {ECO:0000313|EMBL:KFQ58062.1, ECO:0000313|Proteomes:UP000054150} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N334 {ECO:0000313|EMBL:KFQ58062.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK472738; KFQ58062.1; -; Genomic_DNA. DR Proteomes; UP000054150; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054150}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ58062.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054150}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ58062.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFQ58062.1}. SQ SEQUENCE 437 AA; 50233 MW; ADC40D362E64D935 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEGHTNS AILPLLPRET SISSVIW // ID A0A091TC75_PHALP Unreviewed; 551 AA. AC A0A091TC75; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFQ71345.1}; DE Flags: Fragment; GN ORFNames=N335_13489 {ECO:0000313|EMBL:KFQ71345.1}; OS Phaethon lepturus (White-tailed tropicbird). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Phaethontidae; OC Phaethon. OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ71345.1, ECO:0000313|Proteomes:UP000053638}; RN [1] {ECO:0000313|EMBL:KFQ71345.1, ECO:0000313|Proteomes:UP000053638} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ71345.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK444898; KFQ71345.1; -; Genomic_DNA. DR PhylomeDB; A0A091TC75; -. DR Proteomes; UP000053638; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053638}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ71345.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053638}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001881709. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFQ71345.1}. SQ SEQUENCE 551 AA; 62814 MW; 44FAE0F9410D9BC6 CRC64; MLTLCWILAL FVSGAEVTEI NLPGCPHVEP QIWYRAISDE EFVLECALPD RDTTHVYKNS LLKEHKVKWF WRQKDKEPPK AIKESSNPAL QGGALWFKPV KDSASGVYTC VIGEKFPCLK IVLEVQTKKV AKCSSYDTNM LYLLAGSGNS ITCPGTKCYS HIRKQDVKWY KDGHQIKHRK SRQSLKLKQD EIYLNPTYEK DAGIYVCDYT LYDNTTKWTV RTAVTVEVIA KTTIHPPNFL YPSGVVILEA ELGKPLELEC RVQFGFEKVS LMKVTWKRNN KENINEKLNQ ETSVYPKGLK GHTLLHVAKL KEVTERDLRS NFTCFAENSV GNATAVIQLK RKQRVFLLYV LCSAISTLFA FLLCTAFIYQ HWIEIVLLYR SYLVHSETTG DGKEFDAFVS YAKLESSESD STLISEEKFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YVSGPSIFEL QAAVNCALED KKIKVVLIKF QAFQEPETLP PVVKKALRIL PVITWKSSIS AAPDKKFWKY MHYHMPVKTS K // ID A0A091TPY5_PHALP Unreviewed; 398 AA. AC A0A091TPY5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 14. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFQ78947.1}; DE Flags: Fragment; GN ORFNames=N335_12342 {ECO:0000313|EMBL:KFQ78947.1}; OS Phaethon lepturus (White-tailed tropicbird). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Phaethontidae; OC Phaethon. OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ78947.1, ECO:0000313|Proteomes:UP000053638}; RN [1] {ECO:0000313|EMBL:KFQ78947.1, ECO:0000313|Proteomes:UP000053638} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ78947.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK460697; KFQ78947.1; -; Genomic_DNA. DR PhylomeDB; A0A091TPY5; -. DR Proteomes; UP000053638; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053638}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ78947.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053638}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 83 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 398 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ78947.1}. FT NON_TER 398 398 {ECO:0000313|EMBL:KFQ78947.1}. SQ SEQUENCE 398 AA; 46161 MW; 7305940EF9FCEEBF CRC64; DVMEGEALVI KCPQLSSSVK FTWYHTDINK IIPAEEEGSR IFSLKRFLWF LPTSREDSGN YTCVIHFLNN RTKSFNMSVQ VHPYKQGVCF PNQIRYPNDT GRGKIVCPTI DNYKNATIIQ WYKDCKPLQG ERYFKAEKYI FINNPRKEDD GYYTCQFSYT HKGNVFNVSA TRIFISKAKH SPLPPQILFP KDKDVIEVEL GAALPLKCQA RLGIKKQPMD VVTWDVDNVP VKYLDFSRFH EKTHFFQGRE QEYYRETTLH ITEIKKEDLQ ANFTCVAVNE MHNTKATVTL QLKAQCEVGL PNVLLIVGSL VLLVAIAVSL ILYQSFRVDI VLLYREIFQP YSAKDDGKLY DAYVIYPRSH TSEANFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGE // ID A0A091TVW8_PHORB Unreviewed; 547 AA. AC A0A091TVW8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFQ82554.1}; DE Flags: Fragment; GN ORFNames=N337_11621 {ECO:0000313|EMBL:KFQ82554.1}; OS Phoenicopterus ruber ruber. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; OC Phoenicopteridae; Phoenicopterus. OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ82554.1, ECO:0000313|Proteomes:UP000053700}; RN [1] {ECO:0000313|EMBL:KFQ82554.1, ECO:0000313|Proteomes:UP000053700} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ82554.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK406630; KFQ82554.1; -; Genomic_DNA. DR Proteomes; UP000053700; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053700}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ82554.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053700}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 547 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001882060. FT TRANSMEM 342 365 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 134 203 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 238 336 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 389 544 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 547 547 {ECO:0000313|EMBL:KFQ82554.1}. SQ SEQUENCE 547 AA; 62611 MW; 237E7F6D5B29A863 CRC64; MLTLCWILAF VSGAEVREIS LPGCSHVEPQ IWYRAISDEE FVLQCALPDR DATHIYNNSL HKVKWFWHQK DKEPLKAIKK SSNLALQGDA LWFKPVRDSA SGVYICMIRE RIPCLKIVLE VQTKKAAKCS GYDPNMLYLL ASNGNSIACP GTKCYSHIKK SDVKWYKDGH QVKCSKSRQS RKLKHNEIYL NPTYNEDAGI YACDYTLYDN TTKWTMRTLV TVEVITKPTI NPPNFLYPNG VVILEAELGK PLELECRVQF GFERVSLMRV TWKRNNKENI NEKLNQETSF YSKGLKGHTL LHVAKLKEVT ERDLRSNFTC FAENSVGNAT AVIQLKRKQR VFLLYVLCSA ISTLFAFLLC TAFIYQHWIE IVLMYRSYLV HNETTGDGKE FDAFVSYAKL DSSESDSTLI SEEKFALELL PDMLENKYGY KLCILERDIL PGGAYTDEVV TAIKQSRRAI IILSPAYISG PSLFELQAAV NCALEDKKIK LVLIKFQAFQ EPETLPPVVK KALRILPVIT WKSSISAAPN KKFWKYMHYH MPVKTTK // ID A0A091U2Z9_PHORB Unreviewed; 437 AA. AC A0A091U2Z9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFQ84412.1}; DE Flags: Fragment; GN ORFNames=N337_02420 {ECO:0000313|EMBL:KFQ84412.1}; OS Phoenicopterus ruber ruber. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; OC Phoenicopteridae; Phoenicopterus. OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ84412.1, ECO:0000313|Proteomes:UP000053700}; RN [1] {ECO:0000313|EMBL:KFQ84412.1, ECO:0000313|Proteomes:UP000053700} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ84412.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK412527; KFQ84412.1; -; Genomic_DNA. DR Proteomes; UP000053700; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053700}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ84412.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053700}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ84412.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFQ84412.1}. SQ SEQUENCE 437 AA; 50247 MW; ADC40D362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091UMZ4_PHALP Unreviewed; 437 AA. AC A0A091UMZ4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFQ77757.1}; DE Flags: Fragment; GN ORFNames=N335_05724 {ECO:0000313|EMBL:KFQ77757.1}; OS Phaethon lepturus (White-tailed tropicbird). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Phaethontidae; OC Phaethon. OX NCBI_TaxID=97097 {ECO:0000313|EMBL:KFQ77757.1, ECO:0000313|Proteomes:UP000053638}; RN [1] {ECO:0000313|EMBL:KFQ77757.1, ECO:0000313|Proteomes:UP000053638} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N335 {ECO:0000313|EMBL:KFQ77757.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK458452; KFQ77757.1; -; Genomic_DNA. DR PhylomeDB; A0A091UMZ4; -. DR Proteomes; UP000053638; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053638}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ77757.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053638}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ77757.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFQ77757.1}. SQ SEQUENCE 437 AA; 50277 MW; CB8540F08CB88A94 CRC64; GSSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091UNZ0_NIPNI Unreviewed; 874 AA. AC A0A091UNZ0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFQ92321.1}; GN ORFNames=Y956_14498 {ECO:0000313|EMBL:KFQ92321.1}; OS Nipponia nippon (Crested ibis) (Ibis nippon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae; OC Nipponia. OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ92321.1, ECO:0000313|Proteomes:UP000053283}; RN [1] {ECO:0000313|EMBL:KFQ92321.1, ECO:0000313|Proteomes:UP000053283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ92321.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL409846; KFQ92321.1; -; Genomic_DNA. DR RefSeq; XP_009474401.1; XM_009476126.1. DR GeneID; 104022406; -. DR Proteomes; UP000053283; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053283}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ92321.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053283}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 98834 MW; 55664CA1399FED69 CRC64; MRILIGSLHF YFISVLFSRA NGFLAWRTPT AYAFPFYNYS YLNLSSVPEA QAPKTARALN FSHNIIEKIT KRDLEGFDML EVLDLSYNQI KDIEPGAFER LLSLVSVNLS FNDKKLLLSG LPPHLKLLPA SEASGSLQLS KYADKSPAAA REPSASAEEL PRAGGPSVLH NVNLRLRRST ENLLRRAEKN VTASPAPTVR PDFCGAPVNG ILDLSNSKLS EEELTLKLDP DNCQAQLDAI LELDISHSDL EMDLLSLFVL FLPMKNVQSI DASYNKLTIN VLDVEAICNF PFSKVLFLNI SNNPINSLDT LCLPSTIKVI DLSFTNISQI PQNFATKMLN LENMYVQGNH FIYTVRPEIT NAVQKFPPGS VHINAISFVR NQAGTPIESL PKKVKQLKMS NCSIVELPEW FAGTMEELLF LDLSSNRISV LPNLPASLQH LDISNSDIKI IPPGFKSVSN LTIFNIQNNK ITDMHPEYFP LTLTKCDISK NKLSMLSLTD ALENLEYLNV SGNLITRLEP ASHLSALANL DSSHNLISEL PDHFGKSLPM LKYFNLSGNK ISFLQRGALP ASLIELDISD NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNVY IHDPRLQING KGNLRCSFPL ERRGSLVERS NLTLLHCSLG IQMAITACVA ILVVLVLTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEN KPFDAFVSYS EQDANWTKES LLEKLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSVPQKFS KLRKLLKSKT YLKWSPEEHK QKMFWHQLAA ILKTTNEPLV RAEDRPAQDT YEME // ID A0A091UR67_NIPNI Unreviewed; 1026 AA. AC A0A091UR67; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFQ92440.1}; DE Flags: Fragment; GN ORFNames=Y956_08374 {ECO:0000313|EMBL:KFQ92440.1}; OS Nipponia nippon (Crested ibis) (Ibis nippon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae; OC Nipponia. OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFQ92440.1, ECO:0000313|Proteomes:UP000053283}; RN [1] {ECO:0000313|EMBL:KFQ92440.1, ECO:0000313|Proteomes:UP000053283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFQ92440.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL409848; KFQ92440.1; -; Genomic_DNA. DR Proteomes; UP000053283; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053283}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFQ92440.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053283}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ92440.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFQ92440.1}. SQ SEQUENCE 1026 AA; 117950 MW; 3D49306F86281EFD CRC64; LLSGAWFPKS LPCDVTASEG TVTVDCTDRR LLEVPRGIPP NATNLTLSIN HIPHINPTSF AHLENLVEID FRCNCVPVRM GPKDHVCTKR PKIENGSFAA LTRLKSLYLD ANQLLEIPRG LPAALSLLSL EANSIFSIHK ANLSELGNIE VLYLGQNCYY RNPCNVSFEI EKTAFLELKK LTVLSLKSNN LTHIPPNLSS TLKELYIYNN MIQVIQEHDL STLHNLEILD LSGNCPRCYN APYPCIPCPR SAIEIHAKAF YSLENLRILR LHSNSLQSIP SSWFKNIRNL KELDLSQNFL MKEIGDAQFL KFIPSLVELD LSFNFELQMY SPSLNLSKTF SSLSNLETLR LRGYVFKELR KGNLDPLLSL RNLTVLDLGT NFIKIADLRV FKEFPALKFI DLSVNKISPS SGESNFYGFC SNPRISAEQY NRRVLREMHY FRYDEYGRSC RSKDKESASY QSSVKEECLK YGETLDLSRN NIFFINPSDF QGLSFLRCLN LSDNAISQTL NGSEFHHLSG LKYLDFSNNR IDLLYSTAFK ELNHLEILDL SNNKHYFLAE GVSHVLNFTK NLPYLKKLMM NENEISTSIN TGIESQSLQI LEFRGNRLDV LWMDGNARYL SFFKNLTSLE QLDISFNSLS FLPHGVFEAM PPELKILNLT NNQLKSFNWG NLQHLKKLVT LDLSNNLLAT VPRELSNCSS TLQELMLRNN HIQRLSKHFL RGSFKLKYLD LSSNKIQIIK KSSFPENVIN NLRMLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSASTVLGF MVFTVTSHLY FWDVWYSYHY CAAKLKGYRR LSFPDACYDA FVAYDNKDPA VNEWVLTELV ERLEDQKARQ FNLCLEERDW LPGQPVFDNL SQSIQLSKKT IFVLTNKYIT SGRFKTTFYM AHQRLLDEKM DVIILIFLEK VLQKSRYVRL RKRLCRSSVL EWPTNPRSHP YFWQCLKNAI ATSNTLAYNK LLQETV // ID A0A091VIH6_PHORB Unreviewed; 437 AA. AC A0A091VIH6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFQ89408.1}; DE Flags: Fragment; GN ORFNames=N337_01441 {ECO:0000313|EMBL:KFQ89408.1}; OS Phoenicopterus ruber ruber. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Phoenicopteriformes; OC Phoenicopteridae; Phoenicopterus. OX NCBI_TaxID=9218 {ECO:0000313|EMBL:KFQ89408.1, ECO:0000313|Proteomes:UP000053700}; RN [1] {ECO:0000313|EMBL:KFQ89408.1, ECO:0000313|Proteomes:UP000053700} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N337 {ECO:0000313|EMBL:KFQ89408.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK432803; KFQ89408.1; -; Genomic_DNA. DR Proteomes; UP000053700; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053700}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFQ89408.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053700}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFQ89408.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFQ89408.1}. SQ SEQUENCE 437 AA; 49919 MW; 7551102B5B150F9F CRC64; PSLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCYVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRRQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQA DSVQMRHYCR GYEYDVSAAT LPIASVSNHH TYCNIPLTLL NGQLPLNNTM KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A091VQF4_NIPNI Unreviewed; 507 AA. AC A0A091VQF4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFR05672.1}; DE Flags: Fragment; GN ORFNames=Y956_02794 {ECO:0000313|EMBL:KFR05672.1}; OS Nipponia nippon (Crested ibis) (Ibis nippon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae; OC Nipponia. OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR05672.1, ECO:0000313|Proteomes:UP000053283}; RN [1] {ECO:0000313|EMBL:KFR05672.1, ECO:0000313|Proteomes:UP000053283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR05672.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL411326; KFR05672.1; -; Genomic_DNA. DR Proteomes; UP000053283; Unassembled WGS sequence. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 2. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053283}; KW Receptor {ECO:0000313|EMBL:KFR05672.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053283}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFR05672.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFR05672.1}. SQ SEQUENCE 507 AA; 58727 MW; 8C08E94EED6DC6E2 CRC64; DAMEGEALVI KCPPWSSSVK VTWHHTASNK IIPAEEEGSR IFSLNRFLWF LPTSREDSGN YTCVIHFSNN RTKSFNMSVQ VHPYKQGVCF PSQIRYPNDT GRGKIVCPTI DNYKNATIIQ WYKDCKPLQG ERYFKGEKYI FINNPRKKDD GYYTCQFIYT HKGNVFNVSA TRIFISKAKH SPLPPQILFP KDKDVIEVEL GAALSLKCQA RLGIKKQWMA VVTWDVNNIP VKNLDFSRFH EKTHSFEGRG QEYYRETTLH ITEIKKEDLQ ANFTCVAVNE MHNTKATVTL QLKAQCEVGL PNVLLTVGSL VLLVAIAVSV ILYQSFQVDI VLLYREIFQP YSAKDDGKIY DAYVIYPRNH TNEANFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGEDT ASAIEKRMQK SRRLIILLTH QLINCTEPAY DQHIALYNAL IQNDTKVILL EMETIGTYEK LQESLRFIIK RQGTIKWKEQ HTVHPQSSNS RFWKHVRYHM PLTLKSS // ID A0A091VT32_NIPNI Unreviewed; 551 AA. AC A0A091VT32; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFR05673.1}; DE Flags: Fragment; GN ORFNames=Y956_02796 {ECO:0000313|EMBL:KFR05673.1}; OS Nipponia nippon (Crested ibis) (Ibis nippon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae; OC Nipponia. OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR05673.1, ECO:0000313|Proteomes:UP000053283}; RN [1] {ECO:0000313|EMBL:KFR05673.1, ECO:0000313|Proteomes:UP000053283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR05673.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL411326; KFR05673.1; -; Genomic_DNA. DR Proteomes; UP000053283; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053283}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFR05673.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053283}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001881183. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFR05673.1}. SQ SEQUENCE 551 AA; 63212 MW; E4AF31B1EB595D26 CRC64; MLTLCWILAL FVNGVEVREV ILPGCSNVEP QMWYRAISDE EFVLQCALPG RDATHIYNNS LLKKHTVKWF WSQKDEEPLK AIKESSNRAL QGDALWFKPV RASASGVYIC MMREKIPCLK IVLEVQTKNA AKCSDYDTNM LYLLADRGNS ITCPGTKCYS HIKKPDVKWY KDGHQIIRRK SRQSLKLKHN EIYLNPTYKE DAGIYVCDYT LYDNTTKWTM RTVVTVDVIA KNTIHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFEKVS PMRVTWQRNN KENINEKLNQ ETSVYPKGLK GHTLLHVVKL KEVTERDLRS NFTCFAENLV GNATAVIQLK RKQRVFLLYV LCSAISTLFA FLLCTAFIYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLHSSESD SSLISEENFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YISGPSIFEL QAAVNCALED KKIKLVLIKF QAFQEPETLP PIVKKALRIL PVITWNSSIS AAANKKFWKY MHYHMPVKTT K // ID A0A091VUD7_OPIHO Unreviewed; 874 AA. AC A0A091VUD7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 21. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFR06128.1}; GN ORFNames=N306_15595 {ECO:0000313|EMBL:KFR06128.1}; OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae; OC Opisthocomus. OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR06128.1, ECO:0000313|Proteomes:UP000053605}; RN [1] {ECO:0000313|EMBL:KFR06128.1, ECO:0000313|Proteomes:UP000053605} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR06128.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK734309; KFR06128.1; -; Genomic_DNA. DR RefSeq; XP_009929601.1; XM_009931299.1. DR GeneID; 104326514; -. DR PhylomeDB; A0A091VUD7; -. DR Proteomes; UP000053605; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 8. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 9. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053605}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFR06128.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053605}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 98952 MW; 9EB767F4FCE396FA CRC64; MRILIGSLHF YFISFFFSRA NGFLTLRTPA AYAFPFYNYS YLNLSSVSEA QAPKTARALN FSHNIIEKIS KRDLEGFDAL EVLDLSHNRI KNIEPGAFES LLSLVSVNLS FNHKELLASG LPPYLKLLPT SKASGSLQLY KYFDKSSEGA LEPPASAEEL PHSGGPSVLQ NVNPRLRRST EHLLRRAEKN VTVSPEATSR SNFCGAPING TLDLSNSKLS EEELTLKLDP DLCQAQLEGI LELDISHSDL EMDLLSLFVL VLPMKNVQSI DASYNKLTIN ILDVEAICNF PFSKLLFLNI SNNPINSLDT LCLPSTIKVI DLSFTNLSQI PQNFAKKMIN LENMYVQGNH FIYTVRPEIG NGVSKFPPGT VHINAISFVR NEAGTPIQSL PQKVRHLKMS NCSIVELPEW FAGTMEELLF LDLSSNRISV LPDLPTSLQH LDISNSDIKI IPPSFKSVSN LTVFNIQNNK IMDMHPEYFP LTLTKCDISK NKLNMLSLTD ALEKLEYLNV SGNLITRLEP ASHLSALANL DSSHNLISEL PDHFGKSLPM LKYFNLSGNK ISFLQRGALP ASLIELDISD NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNVY IRNPHLQING KGNLRCSFPP DRRGSLVESS NLTLLHCSLG IQMAITACVA ILVVLVLTGL CWRFDGLWYM RMGWYWCMAK RKQYEKRPEN KPFDAFISYS EQDAKWTKEN LLEKLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSVPQKFS KLRKLLKRKT YLKWSPEEHK QKMFWHQLAA VLKTTNEPLV RAENGSAQDM YEME // ID A0A091VUG1_NIPNI Unreviewed; 437 AA. AC A0A091VUG1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFR06814.1}; DE Flags: Fragment; GN ORFNames=Y956_10104 {ECO:0000313|EMBL:KFR06814.1}; OS Nipponia nippon (Crested ibis) (Ibis nippon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Threskiornithidae; OC Nipponia. OX NCBI_TaxID=128390 {ECO:0000313|EMBL:KFR06814.1, ECO:0000313|Proteomes:UP000053283}; RN [1] {ECO:0000313|EMBL:KFR06814.1, ECO:0000313|Proteomes:UP000053283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_Y956 {ECO:0000313|EMBL:KFR06814.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL411406; KFR06814.1; -; Genomic_DNA. DR Proteomes; UP000053283; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053283}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFR06814.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053283}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFR06814.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFR06814.1}. SQ SEQUENCE 437 AA; 50247 MW; ADC40D362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A091W4V1_OPIHO Unreviewed; 503 AA. AC A0A091W4V1; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFR10662.1}; DE Flags: Fragment; GN ORFNames=N306_07827 {ECO:0000313|EMBL:KFR10662.1}; OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae; OC Opisthocomus. OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR10662.1, ECO:0000313|Proteomes:UP000053605}; RN [1] {ECO:0000313|EMBL:KFR10662.1, ECO:0000313|Proteomes:UP000053605} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR10662.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK734773; KFR10662.1; -; Genomic_DNA. DR PhylomeDB; A0A091W4V1; -. DR Proteomes; UP000053605; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053605}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFR10662.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053605}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFR10662.1}. FT NON_TER 503 503 {ECO:0000313|EMBL:KFR10662.1}. SQ SEQUENCE 503 AA; 58556 MW; D0BA90FA1D985B03 CRC64; DAMEGEALVI KCPRWSSSVK ITWYHTESNK IIPAEEEGSR IFSFTRFLWF LPTSREDSGN YTCVIQFSNN RTKSFNMSVQ VYPYKQGVCF PSQIRYPNDT GRGKIVCPTI DNYKNATIVQ WYKDCKPLQG ERYFKGEKYI FIKNQTKEDN GYYTCQFTYT HRGNVFNVSA TRIFISKAKH SPLPPQILFP KDKDIVEVEL GAALSLKCQA RLGIKKQPMA VVTWDVDNIS VKYLGFSRFR EKTHFFEGRE QEYYREATLH IAKIKKEDLR SNFTCVALNE MHNTKATVTL RLKAQCEVGL PNVLLIVGSL VLLVAIAVSV ILYQSFRVDI VLLYREIFQP HPVKDDGKIY DAYVIYPRSH TNEANFVEYF VYQIMPDILE IKCGYNLCIY GRDIYPGEDT ASAIEQRMQK SRRLIILLTH QLINCKEPAY DQHIALYNAL IQNDTKVILL EMEMIGSYEK LQESLRFIIK QQGTIKWKEQ HTVHPQSSNS KFWKQVRYHM PLT // ID A0A091W5B2_OPIHO Unreviewed; 549 AA. AC A0A091W5B2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|EMBL:KFR10664.1}; DE Flags: Fragment; GN ORFNames=N306_07829 {ECO:0000313|EMBL:KFR10664.1}; OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae; OC Opisthocomus. OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR10664.1, ECO:0000313|Proteomes:UP000053605}; RN [1] {ECO:0000313|EMBL:KFR10664.1, ECO:0000313|Proteomes:UP000053605} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR10664.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK734773; KFR10664.1; -; Genomic_DNA. DR PhylomeDB; A0A091W5B2; -. DR Proteomes; UP000053605; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053605}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFR10664.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053605}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 549 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001880998. FT TRANSMEM 340 362 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 19 114 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 142 218 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 386 543 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFR10664.1}. FT NON_TER 549 549 {ECO:0000313|EMBL:KFR10664.1}. SQ SEQUENCE 549 AA; 63741 MW; 57B3C60525269E88 CRC64; QQKMTSTVLV IGCLILLIPL FSAEECVICD YFVLVGEPIA ISCTMFTWPT LHSDYNLTWY KNGSATPITT ERDARIHQRE GLLWFIPATL EDSGLYECDI RSFNHSNQKT VSLTVFKNDN GLCFNGKMKF EQIVMSRNTG KMICPDLEHF KDEDNNQPEV HWYKECKPGF LEDKRLILAD GENAVWIHNV TVQDRGNYTC HIVYTYMGKQ YNVSRTVNLE VKEKPLQRRP KFIYPKNNTI EVELGSHVVM ECNISSDING LIPFWQVNDE DVDSFDSTYR EQFYEEVMPH GIPVSGTKFN ISEVKVQDYA YKFFCHFIYG SQQFTAYIKL ERPAWNIQGY LIGGGVSMVF LVFFTLFIYK IFKIDIVLWY RDFYHPFLGK KVSDGKIYDA YVLYPKNRES CLYSSDIFAL KILPEVLERQ CGYNLFIFGR DDLPGEAVIS VADEKIHQSR RVIIVLVPEP SCYSVTDNVS EKHLAVYNAL VQDSIKIILI ELEKIQDYAD MPETIKYIKQ KHGAIRWKGD FSERSHSAST RFWKKVRYHM PSRKTVSSS // ID A0A091WNZ9_OPIHO Unreviewed; 437 AA. AC A0A091WNZ9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFR03261.1}; DE Flags: Fragment; GN ORFNames=N306_07331 {ECO:0000313|EMBL:KFR03261.1}; OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae; OC Opisthocomus. OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR03261.1, ECO:0000313|Proteomes:UP000053605}; RN [1] {ECO:0000313|EMBL:KFR03261.1, ECO:0000313|Proteomes:UP000053605} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR03261.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK734067; KFR03261.1; -; Genomic_DNA. DR PhylomeDB; A0A091WNZ9; -. DR Proteomes; UP000053605; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053605}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFR03261.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053605}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFR03261.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFR03261.1}. SQ SEQUENCE 437 AA; 50263 MW; B3C5ED362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS SILPLLPRET SISSVIW // ID A0A091WRI3_OPIHO Unreviewed; 1026 AA. AC A0A091WRI3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFR17720.1}; DE Flags: Fragment; GN ORFNames=N306_06722 {ECO:0000313|EMBL:KFR17720.1}; OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae; OC Opisthocomus. OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR17720.1, ECO:0000313|Proteomes:UP000053605}; RN [1] {ECO:0000313|EMBL:KFR17720.1, ECO:0000313|Proteomes:UP000053605} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR17720.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK736151; KFR17720.1; -; Genomic_DNA. DR PhylomeDB; A0A091WRI3; -. DR Proteomes; UP000053605; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053605}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFR17720.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053605}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFR17720.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFR17720.1}. SQ SEQUENCE 1026 AA; 117388 MW; 1A3AF3DF162706DA CRC64; LLSGAWFSKS LPCDVKTSEG TVTVDCTDRR LLEVPRGIPA NATNLTLSIN HIPHINPTSF AGLENLMEID FRCNCVPVRM GPKDCVCIRR PKIENGSFAA LTRLRSLYLD ANQLLEIPRG LPATLSLLSL EANSIFSIQK ANFSELGNIE VLYLGQNCYY RNPCNVSFEI EKTAFLELKR LTILSLKSNN LTHIPPYLSS TLKELYIYNN MIQVIHEHDL SALHNLEILD LSGNCPRCYN APYPCTPCPK TSIEIHSRAF YSLKNLRILR LHSNSLHSIP SSWFQNIMNL QELDLSQNLL VKEIGDAQFL KLLPSLVELD LSFNFEQKTY SPSLNLSKTF SSLSNLETLR LRGYVFKELR GGNLDPLLSL RNLTVLDLGT NFIKVANLTM FKAFPALKLI DLSVNKISPS SGEGDCYGFC SNPRISVEQH NRQVLQEMHY FRYDEYERSC RSKDKEAASY KSSVNEECLN YGETLDLSRN NIFFINPSDF HGLSFLRCLN LSGNAISQAL NGSEFNNLLD LKYLDFSNNR IDLLYSTAFK ELEGLEILDL SNNNHYFLAE GVTHVLSFMK NLAHLKKLMM NENQISTSIN TGLESQSLQI LEFRGNRLDV LWMDGNARYL SFFKNLTRLE QLDISFNSLS FLPHGVFEAM PPELKTLNLT NNGMKSFNWG KLHCLKKLVT LDLSNNLLTA VPRELSNCSS TLQELMLRNN RIQRLTKHFL RGAFKLKYLD LSSNQIQIIK KSSFPENVIN NLRMLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATAVT CAGPGAHKGR SVVFLDLYTC ELDTSYLMLY ALSASTVLGF MVLTVTSHLY FWDVWYSYHY CTAKLKGYRR LSLPDACYDA FVAYDNEDPA VNEWVLTELV ERLEDQKARQ FNLCLQERDW LPGQPVFENL SQSIQLSKKT IFVLTNKYIK SGSFKTTFYM AHQRLLDEKV DVIILIFLEK VLQKSRYVLL RKRLCRNSVL EWPTNPRSQP YFWQCLKNAI ATSNTLAYNK LLQETV // ID A0A091XBD0_OPIHO Unreviewed; 551 AA. AC A0A091XBD0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFR10661.1}; DE Flags: Fragment; GN ORFNames=N306_07825 {ECO:0000313|EMBL:KFR10661.1}; OS Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Opisthocomiformes; Opisthocomidae; OC Opisthocomus. OX NCBI_TaxID=30419 {ECO:0000313|EMBL:KFR10661.1, ECO:0000313|Proteomes:UP000053605}; RN [1] {ECO:0000313|EMBL:KFR10661.1, ECO:0000313|Proteomes:UP000053605} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N306 {ECO:0000313|EMBL:KFR10661.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK734773; KFR10661.1; -; Genomic_DNA. DR PhylomeDB; A0A091XBD0; -. DR Proteomes; UP000053605; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053605}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFR10661.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053605}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001882314. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFR10661.1}. SQ SEQUENCE 551 AA; 63091 MW; 93C08CB9D03E7094 CRC64; MLTLCWILAL FVSGAEVREI NLPGCSHDEP QIWYRAISDE EFVLQCALPD RNAVHIYNNS LLKQHQVKWF WHQKDKESLK AIKESSNLVL QGDALWFKPV RDSASGEYIC MIWGKIPCLK IVLEVQTKKA AKCSGYDTNT LYLLAGNGNS ITCPGTKCYS DIEKPDVKWY KHGHQIKRRK SRQSLKLKPS AIYLNPTYEE DAGIYVCDYT LYDNTTKWTM RTAVTVEVIT KNSIHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFERAS QMTVKWKRNN KENIHEKLNQ ETSVYPKGLK GHILLHVAKL KEVTERDLGS NFTCFAENSV GNATAVIQLK RKQRVYLLYV LCSTISSLFA FLLCTAFIYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLDSSEID STLISEERFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKHS RRAIIILSPA YVSGPSIFEL QAAVNCALED KKIKLVLIKF QAFQEPETLP PVVRKALRIL PVLTWKSSVS AAPNKKFWKY MRYHMPVKTT R // ID A0A093BYD5_9AVES Unreviewed; 437 AA. AC A0A093BYD5; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFV07188.1}; DE Flags: Fragment; GN ORFNames=N339_08450 {ECO:0000313|EMBL:KFV07188.1}; OS Pterocles gutturalis (yellow-throated sandgrouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Pteroclidae; OC Pterocles. OX NCBI_TaxID=240206 {ECO:0000313|EMBL:KFV07188.1, ECO:0000313|Proteomes:UP000053149}; RN [1] {ECO:0000313|EMBL:KFV07188.1, ECO:0000313|Proteomes:UP000053149} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N339 {ECO:0000313|EMBL:KFV07188.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL233299; KFV07188.1; -; Genomic_DNA. DR Proteomes; UP000053149; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053149}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV07188.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053149}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV07188.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFV07188.1}. SQ SEQUENCE 437 AA; 50247 MW; ADC40D362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A093CJZ9_TAUER Unreviewed; 437 AA. AC A0A093CJZ9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFV14818.1}; DE Flags: Fragment; GN ORFNames=N340_04969 {ECO:0000313|EMBL:KFV14818.1}; OS Tauraco erythrolophus (Red-crested turaco). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; OC Tauraco. OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV14818.1, ECO:0000313|Proteomes:UP000053661}; RN [1] {ECO:0000313|EMBL:KFV14818.1, ECO:0000313|Proteomes:UP000053661} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV14818.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL463601; KFV14818.1; -; Genomic_DNA. DR Proteomes; UP000053661; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053661}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV14818.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053661}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV14818.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFV14818.1}. SQ SEQUENCE 437 AA; 49878 MW; E1A04D6CAA3D0D09 CRC64; PSLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQA DSVQMRHYCR GYEYDVSAAT LPIASISNHH TYCNIPLTLL NGQLPLNNTM KDSQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A093CL73_9AVES Unreviewed; 325 AA. AC A0A093CL73; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFV13057.1}; DE Flags: Fragment; GN ORFNames=N339_08326 {ECO:0000313|EMBL:KFV13057.1}; OS Pterocles gutturalis (yellow-throated sandgrouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Ciconiiformes; Pteroclidae; OC Pterocles. OX NCBI_TaxID=240206 {ECO:0000313|EMBL:KFV13057.1, ECO:0000313|Proteomes:UP000053149}; RN [1] {ECO:0000313|EMBL:KFV13057.1, ECO:0000313|Proteomes:UP000053149} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N339 {ECO:0000313|EMBL:KFV13057.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL243125; KFV13057.1; -; Genomic_DNA. DR Proteomes; UP000053149; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053149}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV13057.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053149}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 119 142 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 113 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 166 322 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV13057.1}. FT NON_TER 325 325 {ECO:0000313|EMBL:KFV13057.1}. SQ SEQUENCE 325 AA; 36975 MW; C5767781B701CECD CRC64; IAAKNTMHPP NFLYPSGVVI LQVELGKPLE LECRVQFGFE RVSQMRVTWK RNHKENINEK LNQETRVYSK GLKGHTVLHV AKLKEVTETD LGSNFTCFAE NLVGNATAVI QLKRKQRVFL FYVLCSAIST LFAFLLCTAF IYQHWIEIVL MYRSYLVHNE TTGDGKEFDA FVSYAKLNSS SESDSALISE EKFALELLPN MLENKYGYKL CILERDVLPG GAYTDEVVTA IKQSRRAIII LSPAYISGPS IFELQAAVNC ALEDKKIKVV LIKFQAFQEP ETLPPVVKKA LRILPIITWK SSISAAPNKK FWKYMHYHMP VKSTK // ID A0A093EC43_TAUER Unreviewed; 437 AA. AC A0A093EC43; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFV12056.1}; DE Flags: Fragment; GN ORFNames=N340_00705 {ECO:0000313|EMBL:KFV12056.1}; OS Tauraco erythrolophus (Red-crested turaco). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; OC Tauraco. OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV12056.1, ECO:0000313|Proteomes:UP000053661}; RN [1] {ECO:0000313|EMBL:KFV12056.1, ECO:0000313|Proteomes:UP000053661} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV12056.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL459977; KFV12056.1; -; Genomic_DNA. DR Proteomes; UP000053661; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053661}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV12056.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053661}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV12056.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFV12056.1}. SQ SEQUENCE 437 AA; 50247 MW; ADC40D362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A093EGV0_TYTAL Unreviewed; 437 AA. AC A0A093EGV0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFV42676.1}; DE Flags: Fragment; GN ORFNames=N341_00681 {ECO:0000313|EMBL:KFV42676.1}; OS Tyto alba (Barn owl). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto. OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV42676.1, ECO:0000313|Proteomes:UP000054190}; RN [1] {ECO:0000313|EMBL:KFV42676.1, ECO:0000313|Proteomes:UP000054190} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV42676.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK369167; KFV42676.1; -; Genomic_DNA. DR Proteomes; UP000054190; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054190}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV42676.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054190}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV42676.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFV42676.1}. SQ SEQUENCE 437 AA; 50247 MW; ADC40D362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A093EIT9_TYTAL Unreviewed; 871 AA. AC A0A093EIT9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 21. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFV41812.1}; GN ORFNames=N341_05544 {ECO:0000313|EMBL:KFV41812.1}; OS Tyto alba (Barn owl). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto. OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV41812.1, ECO:0000313|Proteomes:UP000054190}; RN [1] {ECO:0000313|EMBL:KFV41812.1, ECO:0000313|Proteomes:UP000054190} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV41812.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK367363; KFV41812.1; -; Genomic_DNA. DR RefSeq; XP_009973744.1; XM_009975442.1. DR GeneID; 104368164; -. DR Proteomes; UP000054190; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 8. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 9. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054190}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV41812.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054190}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 656 679 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 708 852 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 871 AA; 98861 MW; 1B52C52BEDA0F50D CRC64; MRILTGNLHF YFISFLFSRA NGFLTRRKPT GYAFPFYNYS YLNLSSLSEA QAPKTARALN FSHNIIEKIT KRDLEGFDAL EVLDLSYNWI KDIEPGVFES LLSLVSMNLS FNDEKLLVSG LPPHLELLPT SKASRSLQLC KKSSEVALEL SASHKELPHS GGPPVLKNVK PRVRRSTGNL LRRAEKNVTV SPTVTLGPNF CGAPINGILD LSYSKLSEDE LMLKLDPDLC QDQLDRVLEL DISHSDLEMD LLSLFSLFFP MKNVHSIDAS YNKLTINVLD AEGICNFPFS KLLFLNISNN PINSLDTLCL PSTIKVIDLS FTNISQIPQN FAKKMFNLEN MYVQGNHFIY TVRPESANAV PTFPSGSVRI NAISLVRNQA GTPIESLPKK VKHLKMSNCS IVELPEWFVG TMEELIFLDL SSNRISVLPD LPTSLQHLDI SNSDIKIIPP SFKSLYNLTI FNIQNNKVTA MHPEYFPMTI TKCDISKNKL NMLSLTDALE KLKYLNISGN LITRVEPASR LSALTNLDSS HNLISELPDH FGKSLPMLKH FNLSGNKISF LQRGSLPASL VELDISDNAI TTIVEDTFGQ LTSLSVLTVQ GKHFFCNCDL YWFINVYIHN PDLQINGKGS LRCSFPPDRR GSLVESSNLT LLHCSLGIQM AVTACVAILV VLVLTSLCWR FDGLWYVRMG WYWCMAKRKQ YEKRPENKPF DAFISYSEQD ANWTKENLLE KLETDGFKIC YHERDFKPGH PVLGNIFYCI ENSHKVLFVL SPSFVNSCWC QYELYFAEHR VLNENQDSLI MIVLEDLPPN SVPQKFSKLR KLLKRKTYLK WSPDEHKQKM FWHQLAAVLK TTNEPLVRAE NGSAQEVYEM E // ID A0A093F559_TAUER Unreviewed; 1026 AA. AC A0A093F559; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 20. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFV21766.1}; DE Flags: Fragment; GN ORFNames=N340_04927 {ECO:0000313|EMBL:KFV21766.1}; OS Tauraco erythrolophus (Red-crested turaco). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Musophagiformes; Musophagidae; OC Tauraco. OX NCBI_TaxID=121530 {ECO:0000313|EMBL:KFV21766.1, ECO:0000313|Proteomes:UP000053661}; RN [1] {ECO:0000313|EMBL:KFV21766.1, ECO:0000313|Proteomes:UP000053661} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N340 {ECO:0000313|EMBL:KFV21766.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL476296; KFV21766.1; -; Genomic_DNA. DR Proteomes; UP000053661; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053661}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFV21766.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053661}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV21766.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFV21766.1}. SQ SEQUENCE 1026 AA; 118147 MW; 80F2FBC1C5B2CE86 CRC64; LLSGAWFPKS LPCDVKASEG TVAVDCTDRR LMEVPRGIPE NATNITLNIN HIPHIYPTSF AHLENLVEID FRCNCVPVRM GPKDHVCTRR PKIENGSFAA LTKLKSLYLD ANQLSEIPRG LPTTLSLLSL EANSIFSIQK ANLSELGNIE VLYLGQNCYY RNPCNVSFKI EKTAFLELKK LKILSLKSNN LTHIPPNLSS TLKELYIYNN MIQVIQEHDL SALHNLEILD LSGNCPRCYN APYPCIPCPK STIEIHSNAF HSLKNLRILR LHSNSLQSIP SSWFKNIRNL KELDLSQNFL IKEIRDAQFL KLIPSLVVLD LSFNFELKMY SPSLNLSKTF SSLSNLEILR LRGYVFKELR EGNLDPLLSL RNLTVLDLGT NFIKVADLGA FEKFPALKLI DLSVNKISPS SSESNFYGFC SNPRISLEQY NRQVLQEMHY FRYDEYGRSC RSKEKEATSY PLSVKEECLN YGETLDLSRN NIFFINPSDF RNLSFLRCLN LSGNAISQTL NGSEFYHLSG LKYLDFSNNR IDLLYSTAFE ELKHLEILDL SNNKYYFLAE GVTHVLNFTK NLAHLKKLMM NENEISTSLN TGMESQSLQI LEFRGNRLDV LWMDGNARYL SFFENLTSLE QLDISFNSLG FLPYGVFKTM PPQLKVLNLT NNRMKSFNWG HLHYLKNLVT LDLSNNLLTT VPRKLSNCSS TLQELMLRNN RIHQLTKYFL RGAFKLKYLD LSSNEIQVIK KSSFPENVIN NLRMLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSASTVLGF MVLTVTSHLY FWDVWYIYHY CTAKLKGYRR LSLPDACYDA FIAYDNKDIA VNEWVLTELV ERLEDQKARQ FNLCLEERDW LPGQPVFDNL SQSIQLSRKT IFVLTNKYIK SGSFKTTFYM AHQRLLDEKM DVIILIFLEK VLQKSRYVQL RKRLCRSSVL EWPTNPRSQP YFWQCLKNAI ATSNTLAYNK LLQETV // ID A0A093F574_TYTAL Unreviewed; 437 AA. AC A0A093F574; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFV49356.1}; DE Flags: Fragment; GN ORFNames=N341_02214 {ECO:0000313|EMBL:KFV49356.1}; OS Tyto alba (Barn owl). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto. OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV49356.1, ECO:0000313|Proteomes:UP000054190}; RN [1] {ECO:0000313|EMBL:KFV49356.1, ECO:0000313|Proteomes:UP000054190} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV49356.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK382675; KFV49356.1; -; Genomic_DNA. DR Proteomes; UP000054190; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054190}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV49356.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054190}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV49356.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFV49356.1}. SQ SEQUENCE 437 AA; 49918 MW; F98ACFDCAA2D1C08 CRC64; PSLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQT DSVQMRHYCR GYEYDVSAAT LPIASISNHH TYCNIPLTLL NGQLPLNNTM KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A093FFB0_GAVST Unreviewed; 551 AA. AC A0A093FFB0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFV52961.1}; DE Flags: Fragment; GN ORFNames=N328_02886 {ECO:0000313|EMBL:KFV52961.1}; OS Gavia stellata (Red-throated diver) (Red-throated loon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia. OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV52961.1, ECO:0000313|Proteomes:UP000054313}; RN [1] {ECO:0000313|EMBL:KFV52961.1, ECO:0000313|Proteomes:UP000054313} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV52961.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK624952; KFV52961.1; -; Genomic_DNA. DR Proteomes; UP000054313; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054313}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV52961.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054313}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001882994. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFV52961.1}. SQ SEQUENCE 551 AA; 62956 MW; 717F4A1BDF7C5FC5 CRC64; MLTLCWILAL FVSGAEVREI NLPGCSHVEP QIWYRAISDE EFVLQCALPD RDATHIYNNS ILKQHKVKWF WHQKDNETLK AIKESSNPAL QGDALWFKPV RDSASGVYIC VMWEKIPCLK IVLEVQTKKA AKCSGYDTNM LYLLAGNGNS ITCPGTKCYS HIKKPDVKWY KDGRQIKSRK SRQSLKLKHN EIYLNPTYDE DAGIYVCDYT LYDNTTKWTM RTAVTVEVIA KTTIHPPNIL YPNGVVILEA ELGKPLELEC RVQFGFERAS SMRVTWKRNN KENINEKLNQ ETSVYPNGLK GHTLLHVAKL KEVTERDLRS NFTCFAENSV GNATAVIQLK RKQRVLLLYV LCGAISSLFA FLLFTAFIYQ HWIEIVLMYR SYLAHNETTG DGKEFDAFVS YAKLHSSESD STLISEEKFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YVSGPSIFEL QAAVNCALED KTIKLVLIKF HAFQEPETLP PVVKKALRIL PVVTWKSSIS ATPNKKFWKY MHYHMPVKTT R // ID A0A093FIE8_GAVST Unreviewed; 437 AA. AC A0A093FIE8; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFV54054.1}; DE Flags: Fragment; GN ORFNames=N328_00621 {ECO:0000313|EMBL:KFV54054.1}; OS Gavia stellata (Red-throated diver) (Red-throated loon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia. OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV54054.1, ECO:0000313|Proteomes:UP000054313}; RN [1] {ECO:0000313|EMBL:KFV54054.1, ECO:0000313|Proteomes:UP000054313} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV54054.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK627698; KFV54054.1; -; Genomic_DNA. DR Proteomes; UP000054313; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054313}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV54054.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054313}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV54054.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFV54054.1}. SQ SEQUENCE 437 AA; 50017 MW; 9AC8AA3E6753E8B7 CRC64; PSLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAAEDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFR DLQTVPSLAV TGTSATLVES RSDLTDYHQA DSVQMRHYCR GYEYDVSAAT LPIASISNHH TYCNIPLTLL NGQLPLNNTM KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A093H321_TYTAL Unreviewed; 551 AA. AC A0A093H321; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFV49108.1}; DE Flags: Fragment; GN ORFNames=N341_07099 {ECO:0000313|EMBL:KFV49108.1}; OS Tyto alba (Barn owl). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto. OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV49108.1, ECO:0000313|Proteomes:UP000054190}; RN [1] {ECO:0000313|EMBL:KFV49108.1, ECO:0000313|Proteomes:UP000054190} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV49108.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK382361; KFV49108.1; -; Genomic_DNA. DR Proteomes; UP000054190; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054190}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV49108.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054190}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001884458. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFV49108.1}. SQ SEQUENCE 551 AA; 63315 MW; BC9595597736B105 CRC64; MLTLWWIIVL FISGAEVTEI NLLGCSHVEP QIWYRAISDE EFVLQCALPD RNATHIYKNS LLKQHKVKWF WCQKDKEPLK AVKESSNLAL QGDALWFKPV RDSASGVYIC MIREKIPCLK IVLEVQTKKM AKCSGYDTNT PYLLAGSGNS ITCPGTKCYS HIKKADVKWY KDGHQIKHRK SRQSLKLKHN EIYLNPTYYQ DAGIYVCDYT LYDNTTKWTM RTTVTVEVIA KNTIHPPNFL YPNGVVILEA ELGKPLELEC HVQFGFERVS HMRVTWKRNN KEKINEKLNQ ETRIYPKGLK GHTILHVAKL EEVTERDLRS NFTCFAENSV GNATAVIQLK RKQKVFLLYV LCSAISTLFA FLLCIAFIYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLDSFESD STLISEEKFA LELLPDILEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YISGPSIFEL QAAVNCALED KKIKLVLIKF QAFQEPETLP PVVKKALRIL PVVTWKSSIS AAPNKKFWKY MHYHMPVKAT K // ID A0A093I6J6_FULGA Unreviewed; 874 AA. AC A0A093I6J6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KFV98339.1}; GN ORFNames=N327_12610 {ECO:0000313|EMBL:KFV98339.1}; OS Fulmarus glacialis (Northern fulmar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae; OC Fulmarus. OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFV98339.1, ECO:0000313|Proteomes:UP000053806}; RN [1] {ECO:0000313|EMBL:KFV98339.1, ECO:0000313|Proteomes:UP000053806} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFV98339.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK588117; KFV98339.1; -; Genomic_DNA. DR RefSeq; XP_009585200.1; XM_009586905.1. DR GeneID; 104083424; -. DR Proteomes; UP000053806; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 8. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053806}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV98339.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053806}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 874 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001887184. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 99133 MW; 325C3F4E8BC564E9 CRC64; MRILIGSLHF YFISFLFSRA NGFLTLRTPT AYAFPFYNYS YLNLSSVSKA QAPKTARALN FSHNVIEKIT KRDLEGFDML EVLDLSYNQI KDIEPGAFER LLSLVSVNLS FNDKKLLVSG LPPHLKLSPA SEASGSLQLY KYFDKSPEAA LEPSASAEEL PHSGGPSVLQ NVHLRPRRST EHLLRRAEKN VTVSPTAALR PNFCGAPING ILDLSNSKLC EEELTLKLDP NLCQAQLESI LELDISHTDL EMDLLSLSVL FLPMKNVQSV DASYNKLTIN VLDAEAICNF PFSKLLFLNI SNNPINSLDT LCLPSTIKVI DLSFTNISQI PQNFAKKMFN LENMYVQGND FIYTVRPEIT NAVTKFPPGT VHINAISFVR NQAGTPIESL PKKVKHLKMS NCSIVELPEW FAGTMEELLF LDLSSNRIAV LPDLPTSLRH LDISNSDIKI IPPSFKSVSN LTIFNIQNNK ITDMHPEYFP LTLTKCDISK NKLNLLSLTD ALQKLEYLNV SGNLITRLEA ASHLSALTNL DSSHNLISEL PDRFGESLPM LKYFNLSGNK ISFLQRGSLP ASLIELDISN NAITTIVEDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNVY IHHPHLQING KGHLRCSFPP DRRGSLVESS NLTLLRCSLG IQMAITACVA ILVVLALTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEN KLFDAFVSYS EQDAHWTKEN LLEKLETDGF RICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPNSVPQKFS KLRKLLKRKT YLKWSPEEHK QKMFWRQLAA VLKTTNEPLV RAENGSAQDM YEME // ID A0A093INI0_FULGA Unreviewed; 503 AA. AC A0A093INI0; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFW04280.1}; DE Flags: Fragment; GN ORFNames=N327_02657 {ECO:0000313|EMBL:KFW04280.1}; OS Fulmarus glacialis (Northern fulmar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae; OC Fulmarus. OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW04280.1, ECO:0000313|Proteomes:UP000053806}; RN [1] {ECO:0000313|EMBL:KFW04280.1, ECO:0000313|Proteomes:UP000053806} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW04280.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK597701; KFW04280.1; -; Genomic_DNA. DR Proteomes; UP000053806; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053806}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW04280.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053806}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 80 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 184 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW04280.1}. FT NON_TER 503 503 {ECO:0000313|EMBL:KFW04280.1}. SQ SEQUENCE 503 AA; 58490 MW; 9CA44C4778C7828A CRC64; DAMEGEALVI KCPQWSSSVK VTWYHTDTNK VIPAEEEGSR IFSLKRFLWF LPTSREDSGN YTCVIHFSNN STKSFNMSVQ VHPYKQGVCF PSQIRYPNDT GRGKIVCPTI DNYKNATIIQ WYKDCKPLQG ERYFKEEKYI FINNPRKEDD GYYTCQFIYT HKGNVFNVSA TRIFISKAKH SPLPLQILFP KDKSVKEVEL GAPLSLKCQA RLGIKKQPIA VVTWHVDNIP VKYLDFSRFH EKTHFFEGRE QEYYGETTLH ITEIKEEDLQ ANFRCVVVNE MHNTKATVTL QLKAQCEVGL PNVLLIVGSL VLLVATAVSV ILYQSFRVDI VLLYREIFQP YSAKDDGKIY DAYVIYPRSH TNEANFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGEDT ASAIEKRMQK SRRLIILLTH QLINCKEPAY DQHIALYNAL IQNDTKVILL EMETIGTYEK LQESLRFIIK QQGTVKWKEQ HTVHPQSSNS KFWKQVRYHM PLT // ID A0A093ITT4_EURHL Unreviewed; 437 AA. AC A0A093ITT4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFW05033.1}; DE Flags: Fragment; GN ORFNames=N326_05960 {ECO:0000313|EMBL:KFW05033.1}; OS Eurypyga helias (Sunbittern). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Eurypygidae; Eurypyga. OX NCBI_TaxID=54383 {ECO:0000313|EMBL:KFW05033.1, ECO:0000313|Proteomes:UP000054232}; RN [1] {ECO:0000313|EMBL:KFW05033.1, ECO:0000313|Proteomes:UP000054232} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N326 {ECO:0000313|EMBL:KFW05033.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK567156; KFW05033.1; -; Genomic_DNA. DR Proteomes; UP000054232; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000054232}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW05033.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000054232}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW05033.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFW05033.1}. SQ SEQUENCE 437 AA; 50247 MW; ADC40D362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A093JCH6_STRCA Unreviewed; 507 AA. AC A0A093JCH6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFV76604.1}; DE Flags: Fragment; GN ORFNames=N308_07417 {ECO:0000313|EMBL:KFV76604.1}; OS Struthio camelus australis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae; OC Struthio. OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV76604.1, ECO:0000313|Proteomes:UP000053584}; RN [1] {ECO:0000313|EMBL:KFV76604.1, ECO:0000313|Proteomes:UP000053584} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV76604.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL205917; KFV76604.1; -; Genomic_DNA. DR Proteomes; UP000053584; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 2. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053584}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV76604.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053584}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 78 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV76604.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFV76604.1}. SQ SEQUENCE 507 AA; 58672 MW; E3C81C5BB0B32902 CRC64; DAMEGDALVI KCPPRSSYVR ITWYHTDSNK IIPAEEDGSR IFSSKRFLWF LPTSREDSGN YTCVIHYSNN GTKEFNISVQ VHPYKQGICF PSQIRYPNNT GRGKIVCPTF DNYKNATIIQ WYKDCKPIQG ERYFKGDKYI YINNPGKEDD GFYTCQFIYT HNGKVFNVSA TRIFVSNVKY SPLPPQILFP KHKDVIEVDL GAALSLKCQA RLGIKKQPIA VVTWDVNSIP VKYFDFSRFH EETVFFEGHD QEYYRETTLH ITEIKKEDLQ ANFTCVAVNE MENTKATVTL QLKAQCKVDH PSVLMIIGFL VLLIIIAVSV VIYQSFRVDI VLFYRDIFQP YSAKDDGKIY DAYIIYPKSR TSEANFVENF VYQILPDVLE NKYGYKLCIY GRDICPGEDT ASAVEKRIQK SRRLIIIVTQ QLIHHEDLAY DQHIALYNAL IQNGAKVILL EMETIGTYEK LQESLKYIIK QQGTVKWKEP PTGQPQSSNS KFWKHVRYRM PLTHKTS // ID A0A093JHP4_STRCA Unreviewed; 874 AA. AC A0A093JHP4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-FEB-2018, entry version 21. DE SubName: Full=Toll-like receptor 2 {ECO:0000313|EMBL:KFV78329.1}; GN ORFNames=N308_02506 {ECO:0000313|EMBL:KFV78329.1}; OS Struthio camelus australis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae; OC Struthio. OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV78329.1, ECO:0000313|Proteomes:UP000053584}; RN [1] {ECO:0000313|EMBL:KFV78329.1, ECO:0000313|Proteomes:UP000053584} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV78329.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL206036; KFV78329.1; -; Genomic_DNA. DR RefSeq; XP_009667346.1; XM_009669051.1. DR GeneID; 104140335; -. DR Proteomes; UP000053584; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053584}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV78329.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053584}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 658 681 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 710 854 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 99407 MW; 415EBD00D18B3351 CRC64; MRILIGKLYF YLISFSFSRT NGFLTWRTSR AYAFQFYNYS YLNLSSVSEA HGPKTARVLN FSHNVIEKIA KRDFEGFDAL EVLDLAYNQI KDVEPGAFEN LLSLVSVNFS FNDKKLDVTG LASHLKLLPT GEGSGVLQLY KYFETSSETA LESSVSAKEL QRSKGPSDRL NVNPKFRRSI QDPRRAEKNV TVSPTAGLKP NLCGTPINGI LDLSKSKLSE EDLTEKLDAQ LCQAQLDSIL ELNISHSSLE MDLLSLFILF LPMKNVQSID ASYNKITIDN IDVEAICHFT FHNFFFLNIS NNPLNNLDTI CLPSTIKVID LSFTNISQVP QNFAKKLFNL ENMYVQGNHF IYTVSPENTN ANQKFAPGTV HINAISLVRN EAGTPIESLP EKVKHLKMSN CSIVELPEWF AGTMKELRLL DLSSNPVSTF PHLPISLQHL DISNSDIKVI PPSFKSLSNL TIFNIQNNKI TDMPLEYFPL ALTKCDISKN KLQVLSLTAT LKKLDYLNVS GNLITKLEPT SQLSAITNLD SSHNLISELP DHFGRSLPTL KYLNLSGNKI SFLQSGSLPA SLIELDISNN AITTIVEDTF GQLTSLSVLT AQGKHFFCNC DLYWFVNIYI RNPSLQINGR ENLRCSFPPD RRGSLVENSN LTLLHCSLGI QMAITACVAI LIVLVLTGLC WHFDGLWYVR MGWYWCMSKR KQYEKRPENK LYDAFISYSE HDANWTKENL LEKLEAKGFK ICYHERDFKP GHPVLGNIFY CIENSHKVLF VLSPSFVNSC WCQYELYFAE HRVLNENQDS LIMIVLEDLP FNSVPHKFSK LRKLLKRKTY LKWSPEQHRQ KVFWHQLTAV LKTTNEPLVL RAENGSTEDM YEME // ID A0A093KFZ3_FULGA Unreviewed; 551 AA. AC A0A093KFZ3; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 20-DEC-2017, entry version 14. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFV96692.1}; DE Flags: Fragment; GN ORFNames=N327_06616 {ECO:0000313|EMBL:KFV96692.1}; OS Fulmarus glacialis (Northern fulmar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae; OC Fulmarus. OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFV96692.1, ECO:0000313|Proteomes:UP000053806}; RN [1] {ECO:0000313|EMBL:KFV96692.1, ECO:0000313|Proteomes:UP000053806} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFV96692.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK585332; KFV96692.1; -; Genomic_DNA. DR Proteomes; UP000053806; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000053806}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFV96692.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053806}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001886081. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 207 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 271 291 {ECO:0000256|SAM:Coils}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFV96692.1}. SQ SEQUENCE 551 AA; 63121 MW; 9BFDD8A8C5A6BD0F CRC64; MLTLCWILAL FVSGAEVRET NLSGCSHVEP QIWYRAISDE EFVLQCSLPN RDATHIYNNS LLKDHEVKWF WRQKDKEPLK AIEKSSNPVL QGDALWFKPV RDSASGVYIC MIREKIPCLK IVLEVQTKKA AKCSGYDTNV LYLLAGNGNS ITCPGTKCYS HIEKPDVKWY KDGCQIKRMK NRQSLKLKHN EIYLNPTYDK DAGIYMCDYT LYDNTTKWIM RTAVTVEVIA KTTLHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFERVS LMRVTWKRNN KENTNEKLNQ ETSVYRKGLK GHTLLHVAKL KEVTERDLRS NFTCFAENSV GNATAVVQLK RKQRVYLLHV LCSATSTLFA FLLCTAFIYQ HWIEIVLMYR SYLVHNETTG DGKEFDAFVS YAKLDSSESD STLISEEKFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YVSGPSIFEL QAAVNCALED KKIKLVLIKF QAFQEPETLP PVVKKALRIL PVVTWKSSIS AAPNKKFWKY MHYHMPVKTT K // ID A0A093KQR4_FULGA Unreviewed; 1026 AA. AC A0A093KQR4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFV99900.1}; DE Flags: Fragment; GN ORFNames=N327_10191 {ECO:0000313|EMBL:KFV99900.1}; OS Fulmarus glacialis (Northern fulmar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae; OC Fulmarus. OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFV99900.1, ECO:0000313|Proteomes:UP000053806}; RN [1] {ECO:0000313|EMBL:KFV99900.1, ECO:0000313|Proteomes:UP000053806} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFV99900.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KK590724; KFV99900.1; -; Genomic_DNA. DR Proteomes; UP000053806; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053806}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFV99900.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053806}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFV99900.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFV99900.1}. SQ SEQUENCE 1026 AA; 118092 MW; 72BEEF81C3334A15 CRC64; LLSGAWFPKS LPCDVKVSEG TVTVDCTDRR LLEVPRGIPA NATNLTLSIN HIPHIYPTTF AHLENLMEID FRCNCVPVRM GPKDHVCTRR PKIENGSFAA LTRLKSLYLD ANQLLEIPQG LPTTLSLLSL EANSIFSIQK ANLSELGNIE VLYLGQNCYY RNPCNVSFEI EKTAFLELKK LTILSLKSNN LTHIPPNLSS TLKELYIYNN MIQVIQEHDL SALYNLEILD LSGNCPRCYN APYPCIPCPK NTIEIHSKAF YSLKNLRVLR LHSNSLQSIP SSWFKNIRNL KELDLSQNFL IKEIGDAQFL KFIPSLVELD LSFNFQLQMY SPSLNLSKTF SSLSNLETLR LRGYVFKELR EGNLDPLLSL RNLTVLDLGT NFIKVADLRV FKEFPALKFI DLSVNKISPS SGESNFYGFC SNPRISAEQY NRKLLQEMHY FRYDEYGRSC RSKDKEAASY QSSVKEDCLK YGETLDLSRN NIFFVNPSDF RGLSFLRCLN LSGNAISQTL NGSEFYYLSG LKYLDFSDNR IDLLYSTAFK ELKLLEILDL SNNKHYFLAE GVSHVLSFMK NLAHLKKLMM NENEISTSIN TGMESQSLQI LEFRGNHLDV LWMDGNARYL SFFKNLTSLE QLDISFNSLS FLPNGVFEAM PPELKILNLT NNRIKKLTWE KLRYLKKLVT LDLSNNLLST VPQELSNCSS TLQNFMLRNN QIQRLTKHFL RGAFKLKYLD LSSNKIQIIK KSSFPENVIN NLRMLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSATTVLGF MVFTVTSHLY FWDVWYSYHY CTAKLKGYRR LSLPDACYDA FIAYDNEDPA VNEWVLTELV ERLEDQKARQ FNLCLEERDW LAGQPVFDNL SQSIQLSKKT IFVLTNKYIK SGRFKTTFYM AHQRLLDEKM DVIILIFLEK VLQKSRYVQL RKRLCKSSVL EWPTNPRSQP YFWQCLKNAI ATSNTVAYNK LLQETV // ID A0A093PRS2_9PASS Unreviewed; 507 AA. AC A0A093PRS2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFW79513.1}; DE Flags: Fragment; GN ORFNames=N305_04602 {ECO:0000313|EMBL:KFW79513.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW79513.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW79513.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW79513.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL670503; KFW79513.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW79513.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 322 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 78 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 105 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW79513.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFW79513.1}. SQ SEQUENCE 507 AA; 58786 MW; 5F3D5790B4341B5E CRC64; DPMEGEALVI KCPKWSSSVK VTWYHMDTNK IIPAEEDLSL IFSLELFLLF LPTSREDSGN YTCVTHLSTN RTKSFNVSVQ VHSYKQGVCF PSQIRYPNDT KRGKIVCPTI DNYKNATIVQ WYKDCKPLQG QRYFKQEKYI YIENPTREDD GYYTCQFIYT HKGNVFNASA TRIFISEAKH SPLPPQILFP KNKEVIEVEL GAALSLKCQA LLGIKKQPMS AVIWDVNNIP AKRYNFTRFH EETQFFEGHA QAYYEETTLN ITEVKTEDLQ SNFTCIALNA MHNTRVTVTL QLKTQFEMVL CNVLLIAGSL VLLAAIAVSV ILHQSFRADI VLLYREIFQP YSVKDDGKIY DAYVIYPKNH TNEANFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGEDT ASAIEKRMQR SRRLIILLTH QLINCKEPTY DQHIALYNAL IQNDTKVILL EMERIGTYGK LQESLRFLIK QQGTIKWKEQ HTAHPQSPNS KFWKHVRYHM PLTLKPS // ID A0A093PSU7_9PASS Unreviewed; 551 AA. AC A0A093PSU7; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFW79511.1}; DE Flags: Fragment; GN ORFNames=N305_04600 {ECO:0000313|EMBL:KFW79511.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW79511.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW79511.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW79511.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL670503; KFW79511.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW79511.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001886374. FT TRANSMEM 346 369 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 112 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 117 225 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KFW79511.1}. SQ SEQUENCE 551 AA; 63135 MW; 0EBF629A59C82BAE CRC64; MLTSCWILTL FVSGAEVREI NLPGCSHVEP QIWYRAINGE EFVLQCALPD RDATHIYNNS LPNQHKVKWF WHQKDEETLR VIKESSNLAL QGDALWFKPV RDSASGIYMC TIWEKIPCLK MVLEVQTKKE AKCSAYDTNM LYLLAGSGNS ITCPGTKCYS HIKKPDVKWY KDGHQIKLRK SRPSLKLKHN EIYLNPTYDK DAGIYVCDYT LYDNTTKWTM RTAVTVEVTA KNTIHPPNFL YPNGVVILEA ELGEPLELEC RVQFGFETVS SMRVIWKRNN EENINEKLNQ ETSVYPKGLK GHTLLHVATL KEVTEKDLRS NFTCFAENSV GNATAVIQLK RKQRVLFLYV LCSAVSTLFA FVLCTAFIYQ HWIEIVLMYR SYLAHNKSSG DGKEFDAFVS YAKLDSSERD STFISEEKFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRVIIVLSPA YVSGPSIFEL QAAVNCALED KRIKLVLVKF QAFQEPETLP PAVKKALRIL PVVTWKSFIS APSDKKFWKY MRYHMPVKTT K // ID A0A093PZI4_PHACA Unreviewed; 550 AA. AC A0A093PZI4; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 20-DEC-2017, entry version 13. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFW77437.1}; DE Flags: Fragment; GN ORFNames=N336_09400 {ECO:0000313|EMBL:KFW77437.1}; OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Phalacrocoracidae; OC Phalacrocorax. OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW77437.1, ECO:0000313|Proteomes:UP000053238}; RN [1] {ECO:0000313|EMBL:KFW77437.1, ECO:0000313|Proteomes:UP000053238} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW77437.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL414467; KFW77437.1; -; Genomic_DNA. DR Proteomes; UP000053238; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000053238}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW77437.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053238}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 550 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5005414419. FT TRANSMEM 345 368 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 207 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 339 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 392 547 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 270 290 {ECO:0000256|SAM:Coils}. FT NON_TER 550 550 {ECO:0000313|EMBL:KFW77437.1}. SQ SEQUENCE 550 AA; 62849 MW; 2721920295EA534A CRC64; MLTLCWILAL FVSGAEVREI NLPGCSHVEP QIWYRAISDE EFVLQCALPD RDVTHIYSNS IRKQHKVKWF WHQKDNEPLK AIKESSNPAL QGDALWFKPV RESASGVYVC MIREKIPCLK IILEVQTKKA AKCSGYDTNM LYLLAGKGNS IACPGTKCYS HVKKPDVKWY KDGNQIKHRK SRQSLKLKHN EIYLNPTYDK DAGIYVCDYI LYDNTTKWTV RTAVTVEVIE KNTIHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFERSL MRVTWKRNNK ENTKEKLNQE TSVYTNGLKG HTLLHVAKLN EVTERDLGSN FMCFAENSVG NASAVIQLKR KQRVFLLHVL CSAISALFGF LLCTAFIYQH WIEIVLMYRS YLVHNETAGD GKEFDAFVSY AKLDSSESDS TLISEEKFAL ELLPDMLENK YGYKLCILER DILPGGAYTD EVVTAIKQSR RAIIILSPAY VSGPSIFELQ AAVNCALEDK KIKLVLIKFQ AFQEPETLPP VVRKALRILP VVTWKSSISA APDKKFWKYM HYHMPVKTTK // ID A0A093Q1M9_PHACA Unreviewed; 437 AA. AC A0A093Q1M9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFW80360.1}; DE Flags: Fragment; GN ORFNames=N336_03235 {ECO:0000313|EMBL:KFW80360.1}; OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Phalacrocoracidae; OC Phalacrocorax. OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW80360.1, ECO:0000313|Proteomes:UP000053238}; RN [1] {ECO:0000313|EMBL:KFW80360.1, ECO:0000313|Proteomes:UP000053238} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW80360.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL415640; KFW80360.1; -; Genomic_DNA. DR Proteomes; UP000053238; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053238}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW80360.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053238}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW80360.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFW80360.1}. SQ SEQUENCE 437 AA; 49872 MW; F6C07E6CB1260D12 CRC64; PSLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEEADLANY TCHVENRNGR KHASVLLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQA DSVQMRHYSR GYEYDVSAAT LPIASISNHH TYCNIPLTLL NGQLPLNNTM KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A093Q312_9PASS Unreviewed; 1026 AA. AC A0A093Q312; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFW83373.1}; DE Flags: Fragment; GN ORFNames=N305_04104 {ECO:0000313|EMBL:KFW83373.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW83373.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW83373.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW83373.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL671660; KFW83373.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR025875; Leu-rich_rpt_4. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF12799; LRR_4; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFW83373.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW83373.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFW83373.1}. SQ SEQUENCE 1026 AA; 117953 MW; 5A9D41B80C154367 CRC64; LLSGAWFPKT LPCDVKSSEG TVTVDCTYRR LTQVPRGIPE NVTNLTLSIN HIPHIYPTSF AQLKNLMEID FRCNCVPVRL GPKDLVCNRR LEIENGSFAA LTRLKSLYLD ANQLLEIPRG LPATLTLLSL EANTIFSIQK ANLSELGNIE VLYLGQNCYY RNPCNVSFEI EETAFLELKK LTILSLKSNN LTHIPLNLSS TLKELYIYNN RIQVIQEQDL SALPNLEILD LSGNCPRCYN APYPCIPCTR GSIQIHSKAF DSLKNLRILR LHSNSLQSIP SSWFKNIKNL KELDLSQNFL MKEIGDAQFL KLVPSLVELD LSFNFELKLY SPFLKLSETF SSLSNLETLR LKGYVFKELR EEDLRPLLSL RNLTVLDLGT NFIKVANLTV FEEFPALKFI DLSVNKISPS SGESNSNGFC SNLGFSVEQY NRQVLQEMHY FRYDVYERSC RSKDKEAASY QSSVKEDCLQ FGKTLDLSRN NVFFINPSDF QGLSSLTCLN LSDNAISQTL NGSEFSSLSG LKYLDFSNNR VDLLYQTAFK ELEHLEILDL SNNQHYFLAE GITEELSFIK SLTHLRKLMM NDNDISTTIN TGMESQSLQI LEFRGNRLDV LWMDGNARYL SFFKNLTSLE ELDISFNSLS FLPPTVFEAM PPKLKLLNLT NNRLKSFNWE NLHYLKKLVT LDLSNNLLTT VPRELSNCSS SLQELMLRNN HIHQLTKHFL RGAFKLRYLD LSSNKIEVIK KSSFPENVIN NLKMLLLHGN PFRCNCEAVW FVWWINQTQV TIPLLASDVI CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSASTVLSF MVLAVTSHLY FWDVWYSYHY CTAKLKGYRR LSLPDACYDA FIAYDNEDPA VNDWVMEELV RRLEDRKARQ FNLCLEARDW LPGHPVFDNL SQSIQLSKKT VFVLTNKYIK SGSFRTTFYM AHQRLLDEKL DVIILIFLEK VLQKSRYVRL RKRLCRNSVL EWPTNPQSQP FFWQCLKNAI ATNNLLAYNK LLQETV // ID A0A093QDI6_9PASS Unreviewed; 660 AA. AC A0A093QDI6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFW86616.1}; DE Flags: Fragment; GN ORFNames=N305_09974 {ECO:0000313|EMBL:KFW86616.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW86616.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW86616.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW86616.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL672654; KFW86616.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW86616.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 331 352 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 20 106 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 124 206 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 213 321 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 374 533 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW86616.1}. FT NON_TER 660 660 {ECO:0000313|EMBL:KFW86616.1}. SQ SEQUENCE 660 AA; 75565 MW; 42578B45CC03AAC2 CRC64; SVDGCIDWSV DLKTYMALAG EPVRVKCALF YSYIRTNYSM AQSTGLRLMW YKNKGDLEEP IIFSEVRMSK DEDSIWFHSV ELQDSGFYTC VLRNSTYCMK VSMSLTVAEN ESGLCYNSKI RYLEKSEVTK RKTISCPDIE DYKTAGQEPD VVWYKECKPK MWRSVVIQKG NTLLIQEVQE EDGGNYTCEL KFEGKLIRRT VELKVTALLT DKPPKPLFPM ENQPTVIDVQ LGNPLTVACK AFFGFSGESG PMIYWMKGEK FIEELEGHIR EGEVRLLREH LGEKEVELTL IFDAVGEADL ANYTCHVENR NGRKHASVLL RKKDLIYKIE LAGGLGAILL LLILLVTIYK CYNIELMLFY RQNFGGDEAA DDNKEYDAYL SYTKVDPDAL DRDTNEEEQF ALEILPDVLE KHYGYKLFIP DRDLIPSGTY IEDLTRCVEQ SRRLIIVLTP DYVLRRGWSI FEMENRLHNM LVSGEIKVIL IECTELKGKV NYHEVESLKH TIKLLSVVKW KGPKSSKLNS KFWKRLVFEM PGKKKEVVSR HQVLDSAEQG LFGDLQTIPS VAVTGTSATL VESRADLTDY HQADSVHMRH YCRGYEYDVS AATLPIASIS NHHTYCNIPL TLLNGQLPLN NTVKDPQEFH RNNPLLPLSA KELSFTSDIW // ID A0A093QGZ9_9PASS Unreviewed; 1026 AA. AC A0A093QGZ9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFW83372.1}; DE Flags: Fragment; GN ORFNames=N305_04103 {ECO:0000313|EMBL:KFW83372.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW83372.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW83372.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW83372.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL671660; KFW83372.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR025875; Leu-rich_rpt_4. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF12799; LRR_4; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFW83372.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW83372.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFW83372.1}. SQ SEQUENCE 1026 AA; 117815 MW; 3CBC9C42083418CB CRC64; LLSGAWFPKT LPCDVKSSEG TVTVDCTYRR LTQVPRGIPE NVTNLTLSIN HIPHIYPTSF AQLKNLMEID FRCNCVPVRL GPKNLICNRG LEIENGSFAA LTRLKSLYLD ANQLLEIPRG LPATLTLLSL EANTIFSIQK ANLSELGNIE VLYLGQNCYY RNPCNVSFEI EETAFLELKK LTILSLKSNN LTHIPLNLSS TLKELYIYNN RIQVIQEQDL SALPNLEILD LSGNCPRCYD APYPCIPCTR GSIQIHSKAF DSLKNLRILR LHSNSLQSIP SSWFKNIKNL KELDLSQNFL MKEIGDAQFL KLVPSLVELD LSFNFELKLY SPFLKLSETF SSLSNLETLR LKGYVFKELR EEDLRPLLSL RNLTVLDLGT NFIKVANLTV FEEFPALKFI DLSVNKISPS SGESSSNGFC SNLGFSVEQY NRQVLQEMHY FRYDVYERSC RSKDKEAASY QSSVKEDCLQ FGKTLDLSRN NVFFINPSDF QGLSSLTCLN LSDNAISQTL NGSEFSSLSG LKYLDFSNNR VDLLYQTAFK ELEHLEILDL SNNQHYFLAE GITEELSFIK SLTHLRKLMM NDNDISTTIN TGMESQSLQI LEFRGNRLDV LWMDGNARYL SFFKNLTSLE ELDISFNSLS FLPPTVFEAM PPKLKLLNLT NNRLKSFNWE NLHYLKKLVT LDLSNNLLTT VPRELSNCSS SLQELMLRNN HIHQLTKHFL RGAFKLRYLD LSSNKIEVIK KSSFPENVIN NLKMLLLHGN PFRCNCEAVW FVWWINQTQV TIPLLASDVI CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSASTVLSF MVLAVTSHLY FWDVWYSYHY CTAKLKGYRR LSLPDACYDA FIAYDNEDPA VNDWVMEELV RRLEDRKARQ FNLCLEARDW LPGHPVFDNL SQSIQLSKKT VFVLTNKYIK SGSFRTTFYM AHQRLLDEKL DVIILIFLEK VLQKSRYVRL RKRLCRNSVL EWPTNPQSQP FFWQCLKNAI ATNNSLAYNK LLQETV // ID A0A093QJ76_9PASS Unreviewed; 437 AA. AC A0A093QJ76; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFW88978.1}; DE Flags: Fragment; GN ORFNames=N305_05284 {ECO:0000313|EMBL:KFW88978.1}; OS Manacus vitellinus (golden-collared manakin). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus. OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW88978.1, ECO:0000313|Proteomes:UP000053258}; RN [1] {ECO:0000313|EMBL:KFW88978.1, ECO:0000313|Proteomes:UP000053258} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW88978.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL761274; KFW88978.1; -; Genomic_DNA. DR Proteomes; UP000053258; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053258}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW88978.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053258}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW88978.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFW88978.1}. SQ SEQUENCE 437 AA; 50197 MW; E1EC43240FB84037 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP SYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITN EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A093QKP2_PHACA Unreviewed; 507 AA. AC A0A093QKP2; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:KFW89126.1}; DE Flags: Fragment; GN ORFNames=N336_00937 {ECO:0000313|EMBL:KFW89126.1}; OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Phalacrocoracidae; OC Phalacrocorax. OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW89126.1, ECO:0000313|Proteomes:UP000053238}; RN [1] {ECO:0000313|EMBL:KFW89126.1, ECO:0000313|Proteomes:UP000053238} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW89126.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL421614; KFW89126.1; -; Genomic_DNA. DR Proteomes; UP000053238; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053238}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW89126.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053238}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 303 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 78 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 291 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW89126.1}. FT NON_TER 507 507 {ECO:0000313|EMBL:KFW89126.1}. SQ SEQUENCE 507 AA; 59331 MW; 5DCA5948ECACEFC0 CRC64; DAMEGEALVI KCPRRNSFVK VTWYHTDTNK IIPAEEEGSR VFSSKLFLWF LPTSTEDSGN YTCVIHFSNN RTKSFNMSVW VHPYKKGVCF PSQIRYPNDT GRGKIVCPTI DNYKNATLIQ WYKDCKPLQG ERYLQKEKYI FINNPRKEDD GHYTCRFIYT HKGNVFNVSA TRIFISKAKH SPLPPQILFP KDKDVIEVEL GAALSLKCQA RLGIKKQPLD VVTWDVNNIQ VKYLDFSRFH EESHFFEGYE QEYYRETTLH ITEIRKEDLQ ANFTCVVVNE MHNTRATVRL QLKAQYEVGL PNILLIVGSL VLLVAIAISV ILYQSFRVDI VLLYREIFQP YSLKDDGKIY DAYVIYPRSH TNEANFVEYF VYQIMPDILE NKCGYKLCIY GRDIYPGEDI ASAIEKRIHK SRRLIILLTH QLINCKEPAY DQHIALYNAL IQNDTKVILL EMETIGTYEK LQESLRFIIK RQGTVKWKER HTVHPQSSNS RFWKQVRYHM PLALKSS // ID A0A093QZQ9_PHACA Unreviewed; 437 AA. AC A0A093QZQ9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KFW94368.1}; DE Flags: Fragment; GN ORFNames=N336_12503 {ECO:0000313|EMBL:KFW94368.1}; OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Pelecaniformes; Phalacrocoracidae; OC Phalacrocorax. OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW94368.1, ECO:0000313|Proteomes:UP000053238}; RN [1] {ECO:0000313|EMBL:KFW94368.1, ECO:0000313|Proteomes:UP000053238} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW94368.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL441704; KFW94368.1; -; Genomic_DNA. DR Proteomes; UP000053238; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053238}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFW94368.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053238}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFW94368.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFW94368.1}. SQ SEQUENCE 437 AA; 50187 MW; 33360D363B95E200 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSCE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A094KMS9_9AVES Unreviewed; 548 AA. AC A0A094KMS9; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KFZ59915.1}; DE Flags: Fragment; GN ORFNames=N338_02955 {ECO:0000313|EMBL:KFZ59915.1}; OS Podiceps cristatus (great crested grebe). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Podicipediformes; Podicipedidae; OC Podiceps. OX NCBI_TaxID=345573 {ECO:0000313|EMBL:KFZ59915.1, ECO:0000313|Proteomes:UP000053854}; RN [1] {ECO:0000313|EMBL:KFZ59915.1, ECO:0000313|Proteomes:UP000053854} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N338 {ECO:0000313|EMBL:KFZ59915.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL261773; KFZ59915.1; -; Genomic_DNA. DR Proteomes; UP000053854; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053854}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFZ59915.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053854}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 548 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001901310. FT TRANSMEM 343 366 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 114 204 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 233 337 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 390 545 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 548 548 {ECO:0000313|EMBL:KFZ59915.1}. SQ SEQUENCE 548 AA; 62560 MW; 37BD53666D45D969 CRC64; MLTLCWILAL FVSGAEVREI NLPGCSHVEP QIWYRAIKDE EFVLQCALPE RDAAHIYNNS PHNVKWFWRQ KDKGPLKAIK ESSNLALQGD ALWFKPVRDS ASGVYICMIR EKIPCLKIVL EVQTKKAAKC SGYDTNMLYL LASNGNSIAC PGTKCYSHIK KSDVKWYKDG HQVKSSKSRQ SLKLKHNEIY LNPTYKEDAG IYVCDYTLHD NTTKWTMRTL VTVEVITKNT IHPPNFLYPN GVVTLEAELG KPLELECRVQ FGFERVSLMK VTWKRTNKEN TNEKLNQETS FYSKGLKGHT LLHVAKLKEV TERDLGNNFT CFAENSVGNA TAVIQLKRKQ RVFLLYVLCS AISTLFAFLL CTAFIYQHWI EIVLMYRSYL VHNETTGDGK EFDAFVSYAK LDSSESDSTL ISEEKFALEL LPDMLENKYG YKLCILERDI LPGGAYTDEV VTAIKQSRRV LIILSPAYIS GPSIFELQAA VNCALEDKKI KLVLIKFQAF QEPETLPAVV KKALRILPVI TWKSSISAVP NKKFWKYMHY HMPVKTTK // ID A0A094L1Z6_ANTCR Unreviewed; 1026 AA. AC A0A094L1Z6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFZ65408.1}; DE Flags: Fragment; GN ORFNames=N321_11625 {ECO:0000313|EMBL:KFZ65408.1}; OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus OS carolinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Caprimulgiformes; Caprimulgidae; OC Antrostomus. OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ65408.1, ECO:0000313|Proteomes:UP000053620}; RN [1] {ECO:0000313|EMBL:KFZ65408.1, ECO:0000313|Proteomes:UP000053620} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ65408.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL360981; KFZ65408.1; -; Genomic_DNA. DR Proteomes; UP000053620; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053620}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KFZ65408.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053620}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 817 841 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFZ65408.1}. FT NON_TER 1026 1026 {ECO:0000313|EMBL:KFZ65408.1}. SQ SEQUENCE 1026 AA; 117700 MW; A298190CEA521C6A CRC64; LLSGAWFPKS LPCDVQVSEG TVTVDCTDRR LMEVPKGIPA NATNLTLNIN HIPHIYPTSF ARLENLVEID FRCNCVPFRM GPKDHVCIKS PKIENGSFAA LTRLKSLYLD ANQLSEIPQG LPTTLSLLSL EANSISSIQK ANFSELGNIE VLYLGQNCYY RNPCNVSFEI EDTAFLELKK LTVLSLKCNN LTHIPPNLSS TLKELYIYNN MIQVIQEHDL SALHNLEILD LSGNCPRCYN APYPCIPCPK STIEIHAKAF YSLKNLRILR LHSNSLQSIP SSWFQNIRNL KELDLSQNFL LKEIGDAQFL KFISSLVVLD LSFNFELKMY STTLNLSKTF SSLSNLETLR LRGYVFKELR EGNLYPLLSL RNLTVLDLGT NFIKVADLRV LKKFPALKLM DLSVNKISPS SGESNFYGFC SNPGISVEQY NRQVLQEMHY FRYDEYGRSC RSKDKEAASY QSSVKKECLK YGETLDLSRN NIFFINPSDF RGLSFLRCLN LSGNAISQTL NGSEFSFLSG LKYLDFSNNR IDLLYSTAFE ELKFLEILDL SNNKHYFVAE GVSHMLSFMK NLAYLKKLMM NENEISTSIN TGMESQSLQI LEFRGNRLDV LWMDGNARYL SFFKNLTSLE QLDISFNSLS FLPHGVFEAM PPELKILNLT NNRLKNFAWG SLSSLKKLVT LDLSNNLLTT LPRELSNCSS TLQELMLRNN RIKQLTKHFL RDAFELKYLD LSSNEIQIIK KSSFPENVIN NLRVLLLHGN PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGR SVVFLDLYTC ELDTSYLILY ALSASTILGF MVFTVMSHLY FWDVWYSYHY CTAKLKGYRR LSLPDACYDA FIAYDNEDPA VNEWVLTEMV ERLEDQKARQ FNLCLEGRDW LPGQPVFDNL SQSIQLSKKT IFVLTNKYIK SGNFKTTFYM AHQRLLDEKM DVIILIFLEK VLQKSRYVRL RKRLCRSSVL EWPTNPRSQP YFWQCLKNAI ATSNTLAYNK LLQETV // ID A0A094LA78_9AVES Unreviewed; 437 AA. AC A0A094LA78; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 25-OCT-2017, entry version 10. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KFZ68223.1}; DE Flags: Fragment; GN ORFNames=N338_02348 {ECO:0000313|EMBL:KFZ68223.1}; OS Podiceps cristatus (great crested grebe). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Podicipediformes; Podicipedidae; OC Podiceps. OX NCBI_TaxID=345573 {ECO:0000313|EMBL:KFZ68223.1, ECO:0000313|Proteomes:UP000053854}; RN [1] {ECO:0000313|EMBL:KFZ68223.1, ECO:0000313|Proteomes:UP000053854} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N338 {ECO:0000313|EMBL:KFZ68223.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL284012; KFZ68223.1; -; Genomic_DNA. DR Proteomes; UP000053854; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053854}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KFZ68223.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053854}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 108 126 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 98 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 310 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KFZ68223.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KFZ68223.1}. SQ SEQUENCE 437 AA; 49840 MW; 20A7CFEFABF2CCFF CRC64; PSLFFLSSGN PLTVACKAFF GFSGESGPMI YWMKGEKFIE ELEGHIREGE VRLLREHLGE KEVELTLIFD AVEDADLANY TCYVENRNGR KHASVVLRKK DLIYKIELAG GLGAILLLLI LLVTIYKCYN IELMLFYRQN FGGDEAADDN KEYDAYLSYT KVDPDALDCD NNEEEQFALE ILPDVLEKHY GYKLFIPDRD LIPSGTYIED LTRCVEQSRR LIIVLTPDYV LRRGWSIFEM ENRLHNMLVS GEIKVILIEC TELKGKVNYH EVESLKHTIK LLSVVKWKGP KSSKLNSKFW KRLVFEMPGK KKEVVSRHQV LDSAEQGLFG DLQTVPSLAV TGTSATLVES RADLTDYHQA DSVQMRHYCR GYEYDVSAAT LPIASVSNHH TYCNIPLTLL NGQLPLNNTV KDPQEFHRNN PLLPLSAKEL SFTSDIW // ID A0A096MJW6_RAT Unreviewed; 696 AA. AC A0A096MJW6; DT 26-NOV-2014, integrated into UniProtKB/TrEMBL. DT 26-NOV-2014, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:EDL96039.1, ECO:0000313|Ensembl:ENSRNOP00000068289}; GN Name=Il1rapl1 {ECO:0000313|EMBL:EDL96039.1, GN ECO:0000313|Ensembl:ENSRNOP00000068289, ECO:0000313|RGD:727891}; GN ORFNames=rCG_36412 {ECO:0000313|EMBL:EDL96039.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000068289, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000068289, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000068289, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|EMBL:EDL96039.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL96039.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] {ECO:0000313|EMBL:EDL96039.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL96039.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSRNOP00000068289} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000068289}; RG Ensembl; RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AABR07038572; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038573; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038574; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038575; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038576; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038577; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038578; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038579; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038580; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07038581; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH473966; EDL96039.1; -; Genomic_DNA. DR RefSeq; XP_017457576.1; XM_017602087.1. DR UniGene; Rn.214479; -. DR Ensembl; ENSRNOT00000076283; ENSRNOP00000068289; ENSRNOG00000029663. DR GeneID; 317553; -. DR CTD; 11141; -. DR RGD; 727891; Il1rapl1. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR Reactome; R-RNO-388844; Receptor-type tyrosine-protein phosphatases. DR Reactome; R-RNO-9007892; Interleukin-38 signaling. DR Proteomes; UP000002494; Chromosome X. DR Bgee; ENSRNOG00000029663; -. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Receptor {ECO:0000313|EMBL:EDL96039.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 696 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014015481. FT DOMAIN 6 134 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 162 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 350 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 403 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 696 AA; 79797 MW; 3684E9D80A0B3FD9 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR IKCALFYGYI RTNYTLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LVCSVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSSREP NPDEAHTNSA ILPLLPRETS ISSVIW // ID A0A099ZCK5_TINGU Unreviewed; 437 AA. AC A0A099ZCK5; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KGL78753.1}; DE Flags: Fragment; GN ORFNames=N309_07821 {ECO:0000313|EMBL:KGL78753.1}; OS Tinamus guttatus (White-throated tinamou). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus. OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL78753.1, ECO:0000313|Proteomes:UP000053641}; RN [1] {ECO:0000313|EMBL:KGL78753.1, ECO:0000313|Proteomes:UP000053641} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL78753.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL891437; KGL78753.1; -; Genomic_DNA. DR Proteomes; UP000053641; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053641}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KGL78753.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053641}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KGL78753.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KGL78753.1}. SQ SEQUENCE 437 AA; 50233 MW; C3CAA976FD0FFF49 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEGDL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPDEAHTNS AILPLLPRET SISSVIW // ID A0A0A0A6S5_CHAVO Unreviewed; 437 AA. AC A0A0A0A6S5; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 25-OCT-2017, entry version 12. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KGL89617.1}; DE Flags: Fragment; GN ORFNames=N301_05318 {ECO:0000313|EMBL:KGL89617.1}; OS Charadrius vociferus (Killdeer) (Aegialitis vocifera). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; OC Charadrius. OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL89617.1, ECO:0000313|Proteomes:UP000053858}; RN [1] {ECO:0000313|EMBL:KGL89617.1, ECO:0000313|Proteomes:UP000053858} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL89617.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL870832; KGL89617.1; -; Genomic_DNA. DR Proteomes; UP000053858; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053858}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KGL89617.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053858}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KGL89617.1}. FT NON_TER 437 437 {ECO:0000313|EMBL:KGL89617.1}. SQ SEQUENCE 437 AA; 50247 MW; ADC40D362E600215 CRC64; GGSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDDSRVW ESDIRVLKEH LGEQEVSISL ILDSVEEADL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGVM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKTNRE QNPEEAHTNS AILPLLPRET SISSVIW // ID A0A0A0AAZ2_CHAVO Unreviewed; 551 AA. AC A0A0A0AAZ2; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 25-OCT-2017, entry version 11. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KGL91724.1}; DE Flags: Fragment; GN ORFNames=N301_16499 {ECO:0000313|EMBL:KGL91724.1}; OS Charadrius vociferus (Killdeer) (Aegialitis vocifera). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; OC Charadrius. OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL91724.1, ECO:0000313|Proteomes:UP000053858}; RN [1] {ECO:0000313|EMBL:KGL91724.1, ECO:0000313|Proteomes:UP000053858} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL91724.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL871279; KGL91724.1; -; Genomic_DNA. DR Proteomes; UP000053858; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053858}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KGL91724.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053858}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 551 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001966671. FT TRANSMEM 346 372 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 117 207 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 393 548 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 551 551 {ECO:0000313|EMBL:KGL91724.1}. SQ SEQUENCE 551 AA; 63009 MW; 1D9E6145FB4E5B9B CRC64; MLTLCWILAL FVSGAEVREI NLPGCSRVEP QIWYRAISDE EFVLQCALPD KDATHIYNNS FLKQHDVKWF WRQKDSQPLK AINESSNPAL QGDALWFKPV RNNASGVYIC MIWEKIPCLK IVLEVQTKKA AKCSGYDANT LHLLAGNGNS ITCPGTKCYN HIKKPDVKWY KDGHQIKHGK SRQSLKIKHN EIYLNPTYDK DAGIYVCDYT LYDNTIKWTM RTAVTVKVIA KNTIHPPNFL YPNGVVILEA ELGKPLELEC RVQFGFERVS PMRVTWKRNN KENINENLHQ ETSVYPKGLK GHILLHVAKL KEVTERDLRS NFTCFAENSV GNATAVIQLK RKQRVYLLYI LCSAISTLFA LLLCTAFIYQ YWIEIVLMYR SYLVHNKTTG DGKEFDAFVS YAKLDSSESD STLISEEKFA LELLPDMLEN KYGYKLCILE RDILPGGAYT DEVVTAIKQS RRAIIILSPA YVSGPSMFEL QAAVNCALED KKIKVILIKF QAFQEPETLP AVVKKALRIL PIVTWKSSIS AAPNKKFWKY MHYYMPAKTT K // ID A0A0A0AI14_CHAVO Unreviewed; 874 AA. AC A0A0A0AI14; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 28-FEB-2018, entry version 21. DE SubName: Full=Toll-like receptor 2 type-1 {ECO:0000313|EMBL:KGL94124.1}; GN ORFNames=N301_10951 {ECO:0000313|EMBL:KGL94124.1}; OS Charadrius vociferus (Killdeer) (Aegialitis vocifera). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; OC Charadrius. OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL94124.1, ECO:0000313|Proteomes:UP000053858}; RN [1] {ECO:0000313|EMBL:KGL94124.1, ECO:0000313|Proteomes:UP000053858} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL94124.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL871955; KGL94124.1; -; Genomic_DNA. DR RefSeq; XP_009884303.1; XM_009886001.1. DR GeneID; 104287315; -. DR Proteomes; UP000053858; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 5. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053858}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KGL94124.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053858}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 659 682 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 711 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 874 AA; 99327 MW; 0CB2EDA4C5AFDFA0 CRC64; MKILIGSLHF YFISFLFSRA NGFLTRRTRT AYTFPFYNYS YLNLSSVSEA QAPLTARSLN FSHNVIEKIT KRDLEGFEAL EVLDLSYNQI KDIEPGAFES LLSLTSVNLS FNDKKLLVSG LPPHLKLSPV SKASGSLQLY KYFDKSSEAA LEPFASTVEL PHSGGPSVLQ NVNPRLRRST ENLLRRAEKN VTVPPAATLR PNFCAAPING ILDLSNSKLS EDELMLKLDP DLCQAQLDSI LELNISHSDL EMDLLSLFTL FLPMKNVWSI DASHNKLTIN ILDVEAFCNF PSSKLLFLNI SNNPINSLDT LCVPSTIKVI DLSFTNISQI PQNFAKKLIN LENMYVQGNH FIYTVHPELT NTVPKLPSGT VHINAISFVR NQAGTPIESL PKKVRHLKMS NCSIVELPEW FADTMKELLF LDLSSNRISV LPDLPISLQH LDISNSDIKI IPPSFKSVSN LTIFNIQNNK ITDMYPEHFP LTLTKCDFSK NKLNMLSLTD ALERLEYLNV SGNLITRLEP SSRPSTLTNL DSSHNLISEL PDHFGKSLPM LKYFNLSGNK ISFLQRGALP ASLIELDISD NAITTIVEDT FGQLTSLSVL TAQGKHFFCN CDLYWFVNVY IHHPHLQING RGNLRCSFPP DRRGSLVESS NLTLLHCSLG IQMAITACVA MLVVLVLTGL CWRFDGLWYV RMGWYWCMAK RKQYEKRPEN KPFDAFISYS EQDANWTKEN LLEKLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPNFVNS CWCQYELYFA EHRVLNENQD SLIMIVLEDL PPDSVPQKFS KLRKLLKRKT YLKWSPEEHK RKVFWHQLAA VLKTTNEPLV RAENGSAPDM YEME // ID A0A0A0AS42_CHAVO Unreviewed; 660 AA. AC A0A0A0AS42; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:KGL96707.1}; DE Flags: Fragment; GN ORFNames=N301_14457 {ECO:0000313|EMBL:KGL96707.1}; OS Charadrius vociferus (Killdeer) (Aegialitis vocifera). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; OC Charadrius. OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL96707.1, ECO:0000313|Proteomes:UP000053858}; RN [1] {ECO:0000313|EMBL:KGL96707.1, ECO:0000313|Proteomes:UP000053858} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL96707.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL872713; KGL96707.1; -; Genomic_DNA. DR Proteomes; UP000053858; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004910; F:interleukin-1, Type II, blocking receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004077; IL-1_rcpt_II-typ. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01539; INTRLEUKN1R2. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053858}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KGL96707.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053858}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 331 352 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 20 106 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 124 206 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 213 321 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 374 533 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KGL96707.1}. FT NON_TER 660 660 {ECO:0000313|EMBL:KGL96707.1}. SQ SEQUENCE 660 AA; 75735 MW; 4535CB4CEB5A13E5 CRC64; SVDGCIDWSV DLKTYMALAG EPVRVKCALF YSYIRTNYSM AQSTGLRLMW YKNKGDLEEP IIFSEVRMSK DEDSIWFHSV ELRDSGFYTC VLRNSTYCMK VSMSLTVAQN ESGLCYNSKI RYLEKSEVTK RKTISCPDIE DYKTASQEPD VVWYKECKPK MWRSIVIQKG NTLLIQDVQE EDGGNYTCEL KFEGKLIRRT VELKVTALLT DKPPKPLFPM ENQPTVIDVQ LGNPLTVPCK AFFGFSGESG PMIYWMKGEK FIEELEGHIR EGEVRLLREH LGEKEVELTL IFDAVEEADL ANYTCHVENR NGRKHASVLL RKKDLIYKIE LAGGLGAILL LLILLVTIYK CYNIELMLFY RQNFGGDEAA DDNKEYDAYL SYTKVDPDAL DCDNNEEEQF ALEILPDVLE KHYGYKLFIP DRDLIPSGTY IEDLTRCVEQ SRRLIIVLTP DYVLRRGWSI FEMENRLHNM LVSGEIKVIL IECTELKGKV NYHEVESLKH TIKLLSVVKW KGPKSSKLNS KFWKRLVFEM PGKKKEVMSR HQVLDSAEQG LFGDLQTVPS LAVTGTSATL VESRADLTDY HQADSVQMRH YCRGYEYDVS AATLPIASIS NHHTYCNIPL TLLNGQLPLN NTMKDPQEFH RNNPLLPLSA KELSFTSDIW // ID A0A0A0B3L2_CHAVO Unreviewed; 900 AA. AC A0A0A0B3L2; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KGL99900.1}; DE Flags: Fragment; GN ORFNames=N301_00066 {ECO:0000313|EMBL:KGL99900.1}; OS Charadrius vociferus (Killdeer) (Aegialitis vocifera). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; OC Charadrius. OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL99900.1, ECO:0000313|Proteomes:UP000053858}; RN [1] {ECO:0000313|EMBL:KGL99900.1, ECO:0000313|Proteomes:UP000053858} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL99900.1}; RA Zhang G., Li C.; RT "Genome evolution of avian class."; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KL884740; KGL99900.1; -; Genomic_DNA. DR Proteomes; UP000053858; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000053858}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KGL99900.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053858}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 740 887 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:KGL99900.1}. FT NON_TER 900 900 {ECO:0000313|EMBL:KGL99900.1}. SQ SEQUENCE 900 AA; 104256 MW; 9D794B58034B380D CRC64; LLSLEANRIF SIQKANFSEL ANIEVLYLGQ NCYYRNPCNV SYEIEKTAFL ELKKLTILSL KANNLTHIPP NLSSTLKELY IYNNMIQVIQ EHDLSALHNL EILDLSGNCP RCYNAPYPCI PCPKRTIEIH SKAFYSLENL RILRLHSNSL ESVPSSWFKN IKNLQVLDLS QNFLIKEIGE AQFLKFIPSL VELDLSFNFE LKMYSPFLNL SKTFSSLSNL ETLRLRGYVF KELREANLAP LLSLRNLTVL DLETNFIKIA DLKVFKEFPA LKLIDLSVNK ISPSSGESNF YGFCSNPSIS AEQYNRQVLQ EMHYFRYDVY GRSCRSKDKE AASYQSSVKE ECLKYGETLD LSRNNIFFIN PSDFQGLSSL RCLNLSGNAI SQTLNGSEFY HLSALKYLDF SNNRIDLLYS TAFKELELLE ILDLSNNKYY FLAEGVTHTL SFMKNLAHLK KLMMNENEIS TSINTGIESQ SLQILEFRGN RLDVLWMDGN ARYLSFFRNL TSLEQLDISF NSLTFLPHGV FQALPPELKI LNLTNNRMKS FNWGNLQYLE KLVTLDLSNN LLGTVPRELS NCSSTLQELM LRNNRIQRLT KHFLRGAFQL KYLDLSANKI QTIKKSSFPE NVINNLRMLL LHGNPFKCNC DAVWFVWWIN QTQVTIPLLA TDVTCAGPGA HKGRSVVFLD LYTCELDTSY LILYALSAST VLGFMVFTMM SHLYFWDVWY SYHYCAAKLK GYRRLSFPDA CYDAFIAYDN RDPAVNEWVL KELVERLEDE KARQFNLCLE ERDWLPGQPV FDNLSQSIQL SKKTIFVLTN RYIKSGRFKT AFYMAHQRLL DEKMDVIILI FLEKVLQKSR YVRLRKRLCR SSVLEWPTNP RSQPYFWQCL KNAIATSNTL AYNKLLQETV // ID A0A0A0MR17_HUMAN Unreviewed; 437 AA. AC A0A0A0MR17; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|Ensembl:ENSP00000305200}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSP00000305200}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000305200, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., RA Williams G., Williams L., Williamson A., Williamson H., Wilming L., RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000305200} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [3] {ECO:0000313|Ensembl:ENSP00000305200} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AC002367; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC003659; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC112495; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC121343; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC121344; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL008710; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL031803; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877968; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF459039; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0A0MR17; -. DR PeptideAtlas; A0A0A0MR17; -. DR PRIDE; A0A0A0MR17; -. DR Ensembl; ENST00000302196; ENSP00000305200; ENSG00000169306. DR UCSC; uc064yky.1; human. DR EuPathDB; HostDB:ENSG00000169306.9; -. DR HGNC; HGNC:5996; IL1RAPL1. DR OpenTargets; ENSG00000169306; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR ChiTaRS; IL1RAPL1; human. DR Proteomes; UP000005640; Chromosome X. DR Bgee; ENSG00000169306; -. DR ExpressionAtlas; A0A0A0MR17; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50249 MW; FEC52E742A9BC580 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID A0A0B4KHY4_DROME Unreviewed; 1117 AA. AC A0A0B4KHY4; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Toll, isoform C {ECO:0000313|EMBL:AGB96375.1}; GN Name=Tl {ECO:0000313|EMBL:AGB96375.1, GN ECO:0000313|FlyBase:FBgn0262473}; GN Synonyms=CT17414 {ECO:0000313|EMBL:AGB96375.1}, GN Dmel\CG5490 {ECO:0000313|EMBL:AGB96375.1}, GN dToll {ECO:0000313|EMBL:AGB96375.1}, GN dToll1 {ECO:0000313|EMBL:AGB96375.1}, GN EP(3)1051 {ECO:0000313|EMBL:AGB96375.1}, GN EP1051 {ECO:0000313|EMBL:AGB96375.1}, GN Fs(1)Tl {ECO:0000313|EMBL:AGB96375.1}, GN Fs(3)Tl {ECO:0000313|EMBL:AGB96375.1}, GN mat(3)9 {ECO:0000313|EMBL:AGB96375.1}, GN mel(3)10 {ECO:0000313|EMBL:AGB96375.1}, GN mel(3)9 {ECO:0000313|EMBL:AGB96375.1}, GN T1 {ECO:0000313|EMBL:AGB96375.1}, TL {ECO:0000313|EMBL:AGB96375.1}, GN tl {ECO:0000313|EMBL:AGB96375.1}, TOL {ECO:0000313|EMBL:AGB96375.1}, GN toll {ECO:0000313|EMBL:AGB96375.1}, GN Toll-1 {ECO:0000313|EMBL:AGB96375.1}, GN toll-1 {ECO:0000313|EMBL:AGB96375.1}, GN Toll1 {ECO:0000313|EMBL:AGB96375.1}; GN ORFNames=CG5490 {ECO:0000313|EMBL:AGB96375.1, GN ECO:0000313|FlyBase:FBgn0262473}, GN Dmel_CG5490 {ECO:0000313|EMBL:AGB96375.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AGB96375.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AE014297; AGB96375.1; -; Genomic_DNA. DR RefSeq; NP_001262995.1; NM_001276066.2. DR UniGene; Dm.2347; -. DR EnsemblMetazoa; FBtr0330154; FBpp0303187; FBgn0262473. DR GeneID; 43222; -. DR CTD; 109651; -. DR FlyBase; FBgn0262473; Tl. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR OrthoDB; EOG091G00ZN; -. DR ChiTaRS; Tl; fly. DR GenomeRNAi; 43222; -. DR Proteomes; UP000000803; Chromosome 3R. DR ExpressionAtlas; A0A0B4KHY4; differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01462; LRRNT; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 1117 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002092245. FT TRANSMEM 805 828 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 857 996 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1117 AA; 127163 MW; F2378D963C549E14 CRC64; MSRLKAASEL ALLVIILQLL QWPGSEASFG RDACSEMSID GLCQCAPIMS EYEIICPANA ENPTFRLTIQ PKDYVQIMCN LTDTTDYQQL PKKLRIGEVD RVQMRRCMLP GHTPIASILD YLGIVSPTTL IFESDNLGMN ITRQHLDRLH GLKRFRFTTR RLTHIPANLL TDMRNLSHLE LRANIEEMPS HLFDDLENLE SIEFGSNKLR QMPRGIFGKM PKLKQLNLWS NQLHNLTKHD FEGATSVLGI DIHDNGIEQL PHDVFAHLTN VTDINLSANL FRSLPQGLFD HNKHLNEVRL MNNRVPLATL PSRLFANQPE LQILRLRAEL QSLPGDLFEH STQITNISLG DNLLKTLPAT LLEHQVNLLS LDLSNNRLTH LPDSLFAHTT NLTDLRLEDN LLTGISGDIF SNLGNLVTLV MSRNRLRTID SRAFVSTNGL RHLHLDHNDI DLQQPLLDIM LQTQINSPFG YMHGLLTLNL RNNSIIFVYN DWKNTMLQLR ELDLSYNNIS SLGYEDLAFL SQNRLHVNMT HNKIRRIALP EDVHLGEGYN NNLVHVDLND NPLVCDCTIL WFIQLVRGVH KPQYSRQFKL RTDRLVCSQP NVLEGTPVRQ IEPQTLICPL DFSDDPRERK CPRGCNCHVR TYDKALVINC HSGNLTHVPR LPNLHKNMQL MELHLENNTL LRLPSANTPG YESVTSLHLA GNNLTSIDVD QLPTNLTHLD ISWNHLQMLN ATVLGFLNRT MKWRSVKLSG NPWMCDCTAK PLLLFTQDNF ERIGDRNEMM CVNAEMPTRM VELSTNDICP AEKGVFIALA VVIALTGLLA GFTAALYYKF QTEIKIWLYA HNLLLWFVTE EDLDKDKKFD AFISYSHKDQ SFIEDYLVPQ LEHGPQKFQL CVHERDWLVG GHIPENIMRS VADSRRTIIV LSQNFIKSEW ARLEFRAAHR SALNEGRSRI IVIIYSDIGD VEKLDEELKA YLKMNTYLKW GDPWFWDKLR FALPHRRPVG NIGNGALIKT ALKGSTDDKL ELIKPSPVTP PLTTPPAEAT KNPLVAQLNG VTPHQAIMIA NGKNGLTNLY TPNGKSHGNG HINGAFIINT NAKQSDVXDW EKAELFQFDP DDELLFR // ID A0A0D2SPM3_GOSRA Unreviewed; 1158 AA. AC A0A0D2SPM3; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 28-FEB-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KJB46064.1}; GN ORFNames=B456_007G346900 {ECO:0000313|EMBL:KJB46064.1}; OS Gossypium raimondii (New World cotton). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; OC Gossypium. OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB46064.1, ECO:0000313|Proteomes:UP000032304}; RN [1] {ECO:0000313|EMBL:KJB46064.1, ECO:0000313|Proteomes:UP000032304} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23257886; DOI=10.1038/nature11798; RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D., RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R., RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., RA Grover C., Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., RA Marler B.S., Page J.T., Roberts A.W., Romanel E., Sanders W.S., RA Szadkowski E., Tan X., Tang H., Xu C., Wang J., Wang Z., Zhang D., RA Zhang L., Ashrafi H., Bedon F., Bowers J.E., Brubaker C.L., Chee P.W., RA Das S., Gingle A.R., Haigler C.H., Harker D., Hoffmann L.V., Hovav R., RA Jones D.C., Lemke C., Mansoor S., ur Rahman M., Rainville L.N., RA Rambani A., Reddy U.K., Rong J.K., Saranga Y., Scheffler B.E., RA Scheffler J.A., Stelly D.M., Triplett B.A., Van Deynze A., RA Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J., Zaki E.A., RA Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S., RA Wang X., Schmutz J.; RT "Repeated polyploidization of Gossypium genomes and the evolution of RT spinnable cotton fibres."; RL Nature 492:423-427(2012). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM001746; KJB46064.1; -; Genomic_DNA. DR EnsemblPlants; KJB46064; KJB46064; B456_007G346900. DR Gramene; KJB46064; KJB46064; B456_007G346900. DR Proteomes; UP000032304; Chromosome 7. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000032304}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000032304}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 14 155 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 121 148 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1158 AA; 132053 MW; 4A039F7699F2646C CRC64; MLSLPSSSSY ISRKKYDVFL SFRGEDTRKN FTDHLYAALK RSGIVTFRDD PKLEAGEEIA PELFKAIQQS WCSVIVFSET YAFSSWCLEE LAEIVQQHNN DGHKVFPIFY DVDPSDLRKQ KGKVEEAFAR HEERYKEESE KIQRWRNALI QVAAIKGWHL NNRHESEIIR DIVKKISAKP CQTYPVTHSD LVGISERLED LYLKINIGED DVRVIGICGM GGIGKTTLAR VAYTQMSPHF EGKSFISDIR EVSDKCGLVS LQKQLLSQIF HGECFNFFDV HEGSDIISHR LSHKKVLVVL DNVDNIQHLK CLVGRHDWFG LGSRIVVTTR EEHLLRSWPV DDMYEPKTLN PKDALQLFSL KAFHSDTVQK DDFIELSEHV VNYAGGLPLA LEVLGSFLCG RDATQWRSAI ERLKRDSDKE ILNKLRISFD GLEEREKDIF LDIACFFNGE RKDFVIKVLD GCEFFPDIGI DVLIKKSLVK VDKYNRYLKM HELLQEMGRT IVKEKCVDEP GKRCRLWEER DVHHVLTKYT PLFNLKIMNL RGSQNLIKTP DFTTASNLEV LILEGCTKLV DVHPSIGVLR SLKLLNLRDC KSLRTLPTKT GMESLETLIL SGCSNLVRFP DVEGKMERLK TLDLSGCYRV ENLSENLQQA KFLEELDLSE TAITEPPSFI FQFKNLKVLS FNGRKGPSYK LLPNLPSLVK VIQGRRTNPM ARMLPLLSGL SSLRELNLRD CNLCEGDIPP DISGLSCLEE LELSGNNFIS IPASLTRLSK LKELILSNCN MCTLGEADIR SDLSGLYSLL RLDLSGCKML KSLPELPTSI RYMIIDDCSS LEVVASPSKV CNLAGGDEIS AINCFKLAEK INALTLLKEH IKAVRYPRDC FHSSIVDIMM PGSEIPEWFS QQKSDSSIKI PLPINLRKDS QWIGVACCCI FVDNGASRNK MLYCDGSIFR GRNCRRIFWS LGWVGRSFHK LIMKDHLFLR YFLRDELYPI SLEDKYGDCE TNNLWTADCL DQTGDKLQLC FNSKFEPNDR CVKVKKCGVR IVYEKDLEEM KELQCHTTQS SPNFEHIHQH SAQNHGSVGS TSHMKRKIKR EALTVSLGSF VNSFLESSWR EHLSSPNFHT YELEGNEVVV LGGSKVRGSC LGWRSVMEDE SDEARVYW // ID A0A0D3AFQ1_BRAOL Unreviewed; 1094 AA. AC A0A0D3AFQ1; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bo1g153280.1}; OS Brassica oleracea var. oleracea. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo1g153280.1, ECO:0000313|Proteomes:UP000032141}; RN [1] {ECO:0000313|EnsemblPlants:Bo1g153280.1, ECO:0000313|Proteomes:UP000032141} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141}; RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77; RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E., RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., RA Belcram H., Links M.G., Just J., Clarke C., Bender T., Huebert T., RA Mason A.S., Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., RA Batley J., Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., RA Bancroft I., Chalhoub B., Sharpe A.G.; RT "Transcriptome and methylome profiling reveals relics of genome RT dominance in the mesopolyploid Brassica oleracea."; RL Genome Biol. 15:R77-R77(2014). RN [2] {ECO:0000313|EnsemblPlants:Bo1g153280.1} RP IDENTIFICATION. RG EnsemblPlants; RL Submitted (MAR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EnsemblPlants; Bo1g153280.1; Bo1g153280.1; Bo1g153280. DR Gramene; Bo1g153280.1; Bo1g153280.1; Bo1g153280. DR OMA; DELFFEF; -. DR Proteomes; UP000032141; Chromosome C1. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000032141}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000032141}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 45 183 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1094 AA; 124121 MW; 4D67B21D8144C442 CRC64; MDLYLLLVIV ATLLCSRIFS FVYAKFRVQE SSSSSSPPSP QSSLPIHDVF PSFHGADVRK SFLSHLLKEC GSKGINLFID NEITRGEFIG PELKKAIQGS RIAIVLLSKR YASSSWCLDE LVEIMKCKED LGQTVMPVFY EVDPTDVKKQ TGDFGKVFKK TCKGKTNEVT RKWSEALAKV ATLAGYHSKN WDNEAKMIED VAIDVAKKLF NTTPPRDLDE FIGMEAHMNK ISPVLRTDLD EVRMIGIWGP AGIGKTTIAR FLFHQLSHTF QYSVLMMNVK AMCTPPVCSD DYNVKLHLQQ KLLSQLTSQK EEDFKISHLG VAQERLNDKK VLVVLDNVDR LVQLEAMAKE TGWFGHGSRI IVTTQDRKIL NAHRITDIYK VDFPSDCEAI QMFCMYAFGQ KSPEDGFENL VWEVTRLVGK LPLGLRVMGS HFRGMSKQEW ENELPELWRC LDGEIESILM FSYNALSFQP SDKSLISLEI SLISWERERV IMHDLLVQLG RDIVRKQSSE PGQRQFLVDE RETCEVLADD AAGSGSVIGI MFFYGDEINV SERAFEGMSN LQFLRLEVER DGGGDALHLF GGQSYLSRKL RLLDWSYFPM TCLHCIPKPE LLVELSMHDS KLEKLWEGTK PLTNLKWVDL SDSENLKDVS SLSTATSLQE LNLTRCSSLV ELPSSIGNAI HLKKLDLSGC SSLVELPSSI GNATNLQFLS LHRCSSIVEL PSSIGNAIGN LEDLDFSDCS SLVRVPSSIG NATNLMRLDF RRCSSLVELP ASIGNLHKLD SLILRECRKL EVLPVNINLK SLTTLDLTDC SLMQCFPEIS TNIEYMYLTR TAIKEVPSSI SLWPRLDELH LSYSENLKEF PHVLDIMTVL VMSNTEIQEI PPWINRISRL RRLVLKGCKQ LLSFPQLPSS LSELDAKDCE SLERLDFSFL NQKIDLNFTN CFKLNKEARD VIIQTSPYYN FTILPGKEMP NYFNYQANGG SLVLKSNERP SPSSMRWKAC ILLVPKDEAE AVKGERVNVN LWINQNSLRV GHGIKQNRLN YSIYPPLLHP LTEHLYIFDF EADMPSDELF FEFMFLSEYE WMIKECGVHY LNTS // ID A0A0D3AFQ5_BRAOL Unreviewed; 893 AA. AC A0A0D3AFQ5; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 28-MAR-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bo1g153320.1}; OS Brassica oleracea var. oleracea. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo1g153320.1, ECO:0000313|Proteomes:UP000032141}; RN [1] {ECO:0000313|EnsemblPlants:Bo1g153320.1, ECO:0000313|Proteomes:UP000032141} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141}; RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77; RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E., RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., RA Belcram H., Links M.G., Just J., Clarke C., Bender T., Huebert T., RA Mason A.S., Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., RA Batley J., Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., RA Bancroft I., Chalhoub B., Sharpe A.G.; RT "Transcriptome and methylome profiling reveals relics of genome RT dominance in the mesopolyploid Brassica oleracea."; RL Genome Biol. 15:R77-R77(2014). RN [2] {ECO:0000313|EnsemblPlants:Bo1g153320.1} RP IDENTIFICATION. RG EnsemblPlants; RL Submitted (MAR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EnsemblPlants; Bo1g153320.1; Bo1g153320.1; Bo1g153320. DR Gramene; Bo1g153320.1; Bo1g153320.1; Bo1g153320. DR OMA; RCIINTE; -. DR Proteomes; UP000032141; Chromosome C1. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000032141}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000032141}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 1 132 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 893 AA; 98860 MW; 8675297007703DC0 CRC64; FHGADVRKSF LSHLLKECGI KGINLFIDNE IPRGEFIGPE LKKAIQGSRI AIVLLSKRYA SSSWCLGELV EIMKCKEELG QTVMPVFYEV DPTDVKKQTG DFGKVFKKTC KGKRDDEVTR KWSQALAQVA TLAGYHSKNW DNDVKMIEDV ATEVANNLFN STPSRDFDEF IGMEAHMTKI SPVLRTDLDE VRMIGIWGPA GIGKTTIARC LFHQLSHTFQ YSVFLMNVKT MYTPPICSDD YNVKLHLQQK LLSQLLNQKE DLEISHLGVA QERLKDKKVL VVLDNVDQLV QLEAMAKETG WFGHGSRILI TTQDRKILKA HGITDIYKVD FPSDLELPSS IGNAIHLKKL DLSGCSSLIE LPSSIGNATN LQFLSLSNCS SLVELPSSIG NAIHLKKLDL SGCSSLIELP SSIGNATNLQ FLSLSNCSSL VELPSSIGNA IHLKKLDLSG CSSLIELPSS IGNATNLQFL SLSNCSSLVE LPSSLGNATN LQFLSLSNCS SLVELPSSLG NAIRNLKELD FSRCSSLVGV PSSIGNATNL NRLDFSDCSS LVGVPSSIGN ATNLNRLDFS DCSSLVGVPA SIGNHQKLDS LILRECCKLE ALPVNINLKF LTTLDLTDCS LMKCFPEIST NIEYMYLTGT AIKQVPSSIS LWPRLIDLHM SYSENLKEFP HVLDTMTVLV MSNTEIQEIP PWIKRISRLR RLVLTGCKKL LSLPQLPSSL SQLDAKDCES LERLDCSFLN QKISLNFAKC FKLNKEARDV IIQTSTNDVT ILPGKEMPNY FNYQANGGSL VMKLNERPSP SSKIWKACIL LVSKDEVEAG IGQTVRVHHG IKQNSLDVPC LPSLHILFPP LTEHMYIFEL EADVTSDELC FEFRVNEKEW MIKECGVHYV NTS // ID A0A0D3AFR1_BRAOL Unreviewed; 917 AA. AC A0A0D3AFR1; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bo1g153380.1}; OS Brassica oleracea var. oleracea. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo1g153380.1, ECO:0000313|Proteomes:UP000032141}; RN [1] {ECO:0000313|EnsemblPlants:Bo1g153380.1, ECO:0000313|Proteomes:UP000032141} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141}; RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77; RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E., RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., RA Belcram H., Links M.G., Just J., Clarke C., Bender T., Huebert T., RA Mason A.S., Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., RA Batley J., Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., RA Bancroft I., Chalhoub B., Sharpe A.G.; RT "Transcriptome and methylome profiling reveals relics of genome RT dominance in the mesopolyploid Brassica oleracea."; RL Genome Biol. 15:R77-R77(2014). RN [2] {ECO:0000313|EnsemblPlants:Bo1g153380.1} RP IDENTIFICATION. RG EnsemblPlants; RL Submitted (MAR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EnsemblPlants; Bo1g153380.1; Bo1g153380.1; Bo1g153380. DR Gramene; Bo1g153380.1; Bo1g153380.1; Bo1g153380. DR OMA; NREAIQM; -. DR Proteomes; UP000032141; Chromosome C1. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000032141}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000032141}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 51 189 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 917 AA; 103608 MW; 2656B40B301BD2CE CRC64; MYLYLLPVIV ATPLCSRIFS FVYAKFKVQE NKIIASSPSS PSPKSTLPRN CIHDVFPSFH GADVRKSFLS HLLKEFGIKG INLFIDNEIT RGEFIGPELK KAIQGSRIAI VLLSKRYASS SWCLDELVEI MKCKEELSQT VMPVFYEVDP SDVKKQAGDF GKVFKKTCKG KTNEVIVKWS QALAKVATLA GYHSKNWDNE AKMIEDVATD VAKMLFNSTP SRYLDEFIGM EAHMNKILRV LRTDLDEVRM IGIWGPAGIG KTTIARCLFN QLSHSFQYSV FMMNVKAMYT PPICSDDHNV KLHLQQKLLS QLLNQKEDLE ISHLGVAQER LNDKKVLVVL DNVDRLVQLE AMAKETLWFG HGSRIIVTTQ DRKILKAHGI TDIYKVDFPS NREAIQMFCM YAFGKKSPED GFEKLVWEVT RLVGKLPLGL RVMGSHFRGM SKQEWENELP ELWRCLDGEI ESILMFGYNA LSQENKDLFL HIACFFNNEW KDKVVEHLST RFSNMRQRLN VLADKSLISL KRGDVIMHDL LVQLGRDIVR KQSSEPGQRQ FLVDKRETCE VLADDAAGSR SVIGVMFDGH EINVSERAFE GMSNLQFLRL EVERAGGGDA FHLFGGQSNL SRKLRLLKWR FFPMTCLNCI PNPELLVELS MHGSKLEKLW ERTKPLSNLK WVDLAHSKNL KDVFSLSTAT SLQELNLRGC SSLVELPSSI GNAIHLKKLN LSGCSSLVEL PSSIGNATNL QFLSLSSCSS LVELPSSIGN AIRNLKELDF SRCSSLVGVP SSIGNATNLK RLDFRRCSSL VELPASIGNL HKLYSLTLKE CRKLEVLPVN INLKSLRTLD LTDCSLMQSF PEISTNIKYM YLTGTAIKQV PSSISLWPRL IDLHMSYSEN LKDFGYEQHR NTRDFSLDQE NLSSSSG // ID A0A0D3DFC5_BRAOL Unreviewed; 1230 AA. AC A0A0D3DFC5; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 28-FEB-2018, entry version 19. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bo7g107730.1}; OS Brassica oleracea var. oleracea. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo7g107730.1, ECO:0000313|Proteomes:UP000032141}; RN [1] {ECO:0000313|EnsemblPlants:Bo7g107730.1, ECO:0000313|Proteomes:UP000032141} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141}; RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77; RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E., RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., RA Belcram H., Links M.G., Just J., Clarke C., Bender T., Huebert T., RA Mason A.S., Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., RA Batley J., Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., RA Bancroft I., Chalhoub B., Sharpe A.G.; RT "Transcriptome and methylome profiling reveals relics of genome RT dominance in the mesopolyploid Brassica oleracea."; RL Genome Biol. 15:R77-R77(2014). RN [2] {ECO:0000313|EnsemblPlants:Bo7g107730.1} RP IDENTIFICATION. RG EnsemblPlants; RL Submitted (MAR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EnsemblPlants; Bo7g107730.1; Bo7g107730.1; Bo7g107730. DR Gramene; Bo7g107730.1; Bo7g107730.1; Bo7g107730. DR OMA; NWDDEAT; -. DR Proteomes; UP000032141; Chromosome C7. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000032141}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000032141}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 60 198 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 643 663 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1230 AA; 139962 MW; A0BD579EC6794518 CRC64; MDFSLFLNIV AAAIGFFLIF RKLRSHHENE ESDSSSLSTS STPSALSPSS ASSSSSSHVW LHDVFPSFRG EDVRKNFLSH IKKEFKRKTI TFFNDNGIER GESIAPELIR GIRGSNIAIV LLSRNYASSK WCLEELVEIM KCREELGQTV IAIFYTVDPS DVKKLTGDFG KVFRKTCKGK AKEEIRRWKQ ALEKVAIIAG YHLSNWDDEA TVIEDISTYV LNKLVNSPQP SHFDNLVGMS THMIKLKLLL RPGSNEVRMI GIWGPSGIGK STIARVLFSH YSCEFQFSVF MENIKRLCPR PYYDEYSVKL RLQEEFLSRI INQKDIKIQQ LGVVEDRLKD KRVLAILDDV DHSLQIDAIA KEARWFGPGS WIILTTQDKR LLSVHGIDHI YEVEFPPDDE ALEIFCMNAF GQKSPHDGFQ KLAWEVTRLA GNLPLGLRVM GSHFRRRPKH EWEEELPRLR TRLDGEIEHT LKFSYDALCD DNQAIFLHLA CFLKGESLET VERCLEKNFV GVKGCLRVLA EKSLISFELG RIKMHDLLAL LGREIVRKQF IYEPGQRQFL VDAEDICQVL RNDTLGSRNV IGIDLDLSNL DSGLKISDRV FERMSNVVQF LRIKYGYGVG DICQVLHKDK LDSRNVIGID LDLRKLETEL KIIEGVFKRM SNNQFVRIKN SFHSIDPVTC LPSNPRILHW HFFPMTCLPS NINLEFLVEI ILIESNFLEK LWEGNKTIRN LKLMRLSGSK NLKELPDLST ATNLQSLDLN GCPSLTKLPY SIGNAINLRY LDLRNCSSLV DFPSSMENVT TLEELLLTGC SSLVELPSSV KNSFNLMVFM CGGCSNLVEL PLYIPASCHK EIDLRGCSSL RELPSSIGNM TSLEELNLNG CSSLVELPSS IGDLIRLKTL NLNGCSSLVQ VPSSIGNLTY LMKLDLGGCS SLQELPSSMG KMIHLFRLKL YLERRSKLTA LPININMKYL DELLLTDCSS LESFPEISTN ISVLKLTGTS IEEIPPSIMS WPHLSELHMS YFENLKKSQQ ALHRNTDLLL SDTGIQETAP WDKEITDLRH LIIKGCTKKK KWFNVLIVIN CLKLNQEARD LIINTWTRDF ATLPGETVPT YFTYQATGSS LSMNWNGLDT HYFPTSLRFK VCLLLVYKGD AGYGRCPEIS YCINDKLNGV IRYFQRWVKL PPTSEEYLFV FEIEKTVSAP ELVFEFRSNN KYWEIKECGI HPLETLARSC // ID A0A0D3DMP0_BRAOL Unreviewed; 1328 AA. AC A0A0D3DMP0; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 28-FEB-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bo8g050130.1}; OS Brassica oleracea var. oleracea. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo8g050130.1, ECO:0000313|Proteomes:UP000032141}; RN [1] {ECO:0000313|EnsemblPlants:Bo8g050130.1, ECO:0000313|Proteomes:UP000032141} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141}; RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77; RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E., RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., RA Belcram H., Links M.G., Just J., Clarke C., Bender T., Huebert T., RA Mason A.S., Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., RA Batley J., Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., RA Bancroft I., Chalhoub B., Sharpe A.G.; RT "Transcriptome and methylome profiling reveals relics of genome RT dominance in the mesopolyploid Brassica oleracea."; RL Genome Biol. 15:R77-R77(2014). RN [2] {ECO:0000313|EnsemblPlants:Bo8g050130.1} RP IDENTIFICATION. RG EnsemblPlants; RL Submitted (MAR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EnsemblPlants; Bo8g050130.1; Bo8g050130.1; Bo8g050130. DR Gramene; Bo8g050130.1; Bo8g050130.1; Bo8g050130. DR OMA; GINDETC; -. DR Proteomes; UP000032141; Chromosome C8. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 4. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000032141}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000032141}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 59 197 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1328 AA; 148466 MW; AEBF97098D904A39 CRC64; MASSTNDFIR KSRSHQENGS IASSEILFII ESESHQENET MASSSSTLLD PQSSLSHSCL HHVFPSFHGA DVRTNFLSHI VKEFKSKAID LFIDNDIVRS KSIGPELIEA IRGSRIAIVF LSKNYSSSTW CLNELVEIMH CREEFGKTVM SIFYEVDPTD VKKQTGYFGK VFEKTCEGKT EEEIRRWKHA LAEVAQIAGF HSSNCRTVEH LLNFFRKNEA EMIEDIATDV SNKLNLSAPS NDFDGLVGME SRMAELMPLM LELDSHEVLK IGIWGPPGIG KTTIARYIFN RYSRYVDLSV FMDNIKTKYA KTACSDDYSV KLDLQKQFMS QLTNEKDIKN FSHLGIAKDR LKDKSVLVIL DDVDRPVQVE AVAKENSWFG HESLIIVITQ DLKVLKASGI NHIHKVNLPS YDEALQIFCM HAFGQRYSKD GFIELACEVV SLVENLPLGL RVMGSYFQGM SEQDWTEALP RLRTHIGRDG EIASILISYD SLCDEDKHLA LHIACFFNGE SVDIVECCLA KRFLDVTQGL RVLAEKSIIS MKWGKIKMAE LLVQLGRKLV REQSVSEPGK RQFLNDAIGI EEVLSDYKAD NSSVIGINDE TCGDIECTSE RAFERLSNLQ FLRIHGDGIN PRSMNHISQK LRVLCWSSFQ MTCFPSSFNP KFLVKLEMPN SKLEKLWKKT QLLSNLKRMD LSYSRRLKEL PDLSTATNLY DLDLSYCSSL VKLPSSIGNA INLNKLDLRF CSNLVEIPSS IGNAVNLEIF DLHECSSLVK IPSSITTIAS LTSLTLHSCS SLVGLPQNIE TVTEPHHINL NGCSSLVKLP YSIGNATKLE ELDLSGCVSL VELPFSIGNA INLRKLDLTF CLSLLELPSS IGNATKLEEL DLSHCSSFVE LPFSIGNAIN LQKLNLSYCS SLMELPSSIE NAINLRKLNL SYCSSLVELP SCIGNAAKLE ELDISHCSSL VEIPSSIGNA INLQKLKISH CSSLVEVPFS IGSLINLELL NLENCSSLVK LPSFIQNAVS LQELELSEYS SLMGLPSSIQ TINNLHELTL NDCSSMVELP SIMRNVGRFL KCLKLEVLLD DINLESLEVL SFSECSLLES YPESPTYIQE LDPWMGRISR LTRLVLSGMK NLVSLPPLPD SLFVLEAENC ESLERLGSSF RNAYMMLNFR NCFKLNQEAR DIISRTWTSA YAVFPCRKVP QCFTYRSCGS SVKVKLNQLA LGISTKFKAC ILCADSDGVN FPPLSQASVC CSIMSGGNAR TACYKKVGRV SSGHLYTFRV EIETEEVTSP ELVFEFEIQF GNVNSETWEI NECGILQILE VPHDDSHY // ID A0A0D3DMP4_BRAOL Unreviewed; 1625 AA. AC A0A0D3DMP4; DT 29-APR-2015, integrated into UniProtKB/TrEMBL. DT 29-APR-2015, sequence version 1. DT 28-FEB-2018, entry version 17. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bo8g050170.1}; OS Brassica oleracea var. oleracea. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo8g050170.1, ECO:0000313|Proteomes:UP000032141}; RN [1] {ECO:0000313|EnsemblPlants:Bo8g050170.1, ECO:0000313|Proteomes:UP000032141} RP NUCLEOTIDE SEQUENCE. RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141}; RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77; RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E., RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., RA Belcram H., Links M.G., Just J., Clarke C., Bender T., Huebert T., RA Mason A.S., Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., RA Batley J., Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., RA Bancroft I., Chalhoub B., Sharpe A.G.; RT "Transcriptome and methylome profiling reveals relics of genome RT dominance in the mesopolyploid Brassica oleracea."; RL Genome Biol. 15:R77-R77(2014). RN [2] {ECO:0000313|EnsemblPlants:Bo8g050170.1} RP IDENTIFICATION. RG EnsemblPlants; RL Submitted (MAR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EnsemblPlants; Bo8g050170.1; Bo8g050170.1; Bo8g050170. DR Gramene; Bo8g050170.1; Bo8g050170.1; Bo8g050170. DR OMA; SHIAKEF; -. DR Proteomes; UP000032141; Chromosome C8. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 2. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 2. DR Pfam; PF01582; TIR; 2. DR SMART; SM00382; AAA; 2. DR SMART; SM00255; TIR; 2. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 2. DR SUPFAM; SSF52540; SSF52540; 2. DR PROSITE; PS50104; TIR; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000032141}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000032141}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 7 28 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 57 201 TIR. {ECO:0000259|PROSITE:PS50104}. FT DOMAIN 1076 1153 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1625 AA; 182490 MW; D084AD0FE49F793F CRC64; MDSYFSLTNL VAAAICFYAL LGTIFFNMKS RSHQEDKTVA SSSLTVLPPP SSLPPNWKHQ VFPNFHGVDV LENFLSHIVK EFRSKGINLF IDSDIERSKS IGPELTEAIR GSRIAIVLLS KKYASSTWCL NELMEIIKCS EELGQTVMSI FYQVDPTDVK KQTGKTKEEI RRWQHALTEV AQIAGYHLSN WKNEAQMIED IATDVSNKLN FSAPCSDFKG LVGMEYHMVN MGLLLQLKSD KVRKIGILGP PGIGKTTFVR YIFNRYSSEF ELSVFMDNIK RRYATTACSD DYNVKLDLQK QFMSQLTNVT DIKNFSHLGI AKDRLKDKKV LVVLDDVDRL VQVEALAKET SWFGPGTRII ITTQDQRVLK ASGINHIHKV MLPSYDEALQ MFCMYAYNLK YPKDSFKELS CEVVSLVGRL PLGLKVMGSY FRGTCEQDLA EALPKLRTHL DRDGEIVSVL NLLFCEKADI VEGCLAKCFL DVRNELRVLA EKSIISTNMD WGTIEMAKLL VELGRKIVRE QSVDEPGKRQ FLTDAVDVCE VLSDDRAESS GVIGITVKTY EDIECTSERA FERLYNLQFL RILGKGVNPR SMNHISQKLR VLIWPNSEIT CFLSNFNPKF LVKLEMMNSK LKKLWEETKP LNNLKWMNLS RSRRLEELPD LSTATNLYDL DLSYCSSLVK LPSSSGNTIN LQSLDLSFCS KLVEIPPSIG NAIPTSITTI TSLTSLDLSG CSSMVKLSDN IETFTEPNHI NLSGCSSLVE LPSSIGNAIN LQKLNLSHCS SLVELPFSIG SAINLQKLDL SRCSSLVKLP SSIGNAINFH KLNLDRLLKC SKLEVLRSTL LRELDPWIWR ISRLRTLVLN GMKKLVSLPP LPEDCESLER LDCSFDNPDI CLNFVNCFKL NQEARDLISL TPTNGYAVFP GTEVPQCFTY RSSGSSLTVK LIQKSLGIST KFKACILSAD LDGNNYPHWS QASVCCSIMS RGNALTACYR SLGRVIPGHL YTFEVEVETG ELTSNELTKV SSCAFHREGA AVGVVNGRHI CSSQLSLYRK VSPVSSVASS SSLTLLAPPS SLPHNWKHHV FPSFHGADVR TNFLSHIAKE FKSKGINLFI DNNIERSKSI GPELTEAIKG SRIVIVLLSK NYASSTWCLN ELRKNKEGDT KMETCFDGSG SNCRKNESEM IEDIATDVSN KLNLSAPSSD FDGLVGMESQ MTELEPLLQL DSDEVRKIGI WGPPGIGKTT IARYLFNRHS KDFQLNVFID NIKRKYETTA CFDDYSAKLY LQEQLISKLT NVTDIKNFSH LGIAKERLED KKVLVVLDDV DRLVQVEAMA KETSWFGPGS QIIITTQDQN VLKASGINHI HRVNLPSYHN ALEIFCMYAF GQKDPKDGFS DLPYKIVSLV GKLPLGLKVM GSYFRGMSEQ DWIEAHLDRD GEIASILKFS YDSLCDEDKR LFLHIASFFN GEKFDIVEGC LAKCVSDVRH GLRVLTEKSL ISKFLGTIEM DKLLVELARK IVREQSVNEP GKRQFLTDAI GVGEVLSDDR ADSSSVVGFT VGTFDEITWT SERAFERLSN LQFLRILGKG VNPRSMNHMS QKLRVLIWHN FKMTCFPTSF NPKFRVKLKM PYSKA // ID A0A0D9RWZ8_CHLSB Unreviewed; 598 AA. AC A0A0D9RWZ8; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSCSAP00000013137}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSCSAP00000013137}; OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus. OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013137, ECO:0000313|Proteomes:UP000029965}; RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013137, ECO:0000313|Proteomes:UP000029965} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013137} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AQIB01138485; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_008006452.1; XM_008008261.1. DR RefSeq; XP_008006453.1; XM_008008262.1. DR Ensembl; ENSCSAT00000015190; ENSCSAP00000013137; ENSCSAG00000017102. DR GeneID; 103241156; -. DR KEGG; csab:103241156; -. DR CTD; 8807; -. DR GeneTree; ENSGT00760000119071; -. DR KO; K05174; -. DR OMA; YVCDYTQ; -. DR Proteomes; UP000029965; Chromosome 14. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000029965}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000029965}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 598 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002346361. FT TRANSMEM 359 382 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 149 235 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 251 353 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 406 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 598 AA; 68126 MW; 3630577BBF77ED6A CRC64; MLYLGWMFLW LVSGERIKGF NISGCSTKKL LWTYSTRSEE EFILFCDLPE PQKSHFCHRS RLSPTQVPEH LPFTGSKDLS DVQWYRQPSN GDPLEDIRKS YPHIIQDKCT LRFLTPGVNN TGSYICRPKM IKSPCDVACC VKMILEVKPQ SNASCENSAS HKQDLLLGST GSISCPSLSC QSDAQSPEVT WYKNGKLLST TRSNRIVVDE VYVYHQGTYV CDYTQSDTAS SWTVRAVVQV RTIVGDTKLK PDILDPVEST LEVELGKPLT ISCKARFGFE RVFNPVMKWY IKDSDLEWEV SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRTFVCFVQ NSIGNTTQSV QLKEKRRVVL LYILLGTIGT LVAVLVASAL LYRHWIEIVL LYRTYQSKDE TLGDKKDFDA FVSYAKWSSF PSEATSSLTE EHLALSLFPD VLENKYGYTL CLLERDVAPG GAYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR FWTKMRYHMP VKNSQGFTWS QLRITSRIFQ WKGLSTTETT GRSSQPKE // ID A0A0G2K2K7_RAT Unreviewed; 627 AA. AC A0A0G2K2K7; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSRNOP00000072281}; DE SubName: Full=RCG22315 {ECO:0000313|EMBL:EDL99170.1}; GN Name=Il18rap {ECO:0000313|Ensembl:ENSRNOP00000072281, GN ECO:0000313|RGD:727867}; GN ORFNames=rCG_22315 {ECO:0000313|EMBL:EDL99170.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000072281, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000072281, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072281, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|EMBL:EDL99170.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL99170.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] {ECO:0000313|EMBL:EDL99170.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL99170.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSRNOP00000072281} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072281}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AABR07067462; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH473965; EDL99170.1; -; Genomic_DNA. DR RefSeq; XP_008756243.1; XM_008758021.2. DR RefSeq; XP_008765282.1; XM_008767060.2. DR RefSeq; XP_017452283.1; XM_017596794.1. DR RefSeq; XP_017452284.1; XM_017596795.1. DR RefSeq; XP_017459350.1; XM_017603861.1. DR RefSeq; XP_017459351.1; XM_017603862.1. DR UniGene; Rn.105609; -. DR STRING; 10116.ENSRNOP00000020260; -. DR Ensembl; ENSRNOT00000077303; ENSRNOP00000072281; ENSRNOG00000054218. DR GeneID; 373540; -. DR KEGG; rno:373540; -. DR CTD; 8807; -. DR RGD; 727867; Il18rap. DR GeneTree; ENSGT00760000119071; -. DR KO; K05174; -. DR OMA; YVCDYTQ; -. DR Reactome; R-RNO-9012546; Interleukin-18 signaling. DR Proteomes; UP000002494; Chromosome 9. DR Bgee; ENSRNOG00000054218; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042007; F:interleukin-18 binding; TAS:RGD. DR GO; GO:0008283; P:cell proliferation; ISO:RGD. DR GO; GO:0071345; P:cellular response to cytokine stimulus; IEP:RGD. DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD. DR GO; GO:0071351; P:cellular response to interleukin-18; ISO:RGD. DR GO; GO:0032609; P:interferon-gamma production; ISO:RGD. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; ISO:RGD. DR GO; GO:0032635; P:interleukin-6 production; ISO:RGD. DR GO; GO:0042119; P:neutrophil activation; ISO:RGD. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; ISO:RGD. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; ISO:RGD. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 627 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014024548. FT TRANSMEM 358 382 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 148 238 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 250 352 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 405 561 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 627 AA; 71630 MW; E9FB19C907F5750C CRC64; MLCLGWVFLW FVAGEKTTGF NHSACTTKKL LWTYSARGAE NFVLFCDLQE LQKQDFSHRS QSSSTLGPAH QPCSGSEKDL SDVQWYMQPR SGGPLEEINR NSPHMQNKGT LRILAPQMNS IWSYICRPRS RRPQDTACCV KTVLEVKPQR NISCGSSAQD EQVLLLGSTG SIHCPSLSCQ SDVRSPEMTW YKDGRLLPEY KKNPIEMEDI YDFHQGLYVC DYTQSDNVSS WTVRAVVQVR TIDEDTNVKP DILDPVTDTL DVELGKAFTL PCRVQFGFQR YSKPVIKWYV KESTQEWEIS EFVEKRIQST LKNEVIEHTV FLREVTQRDL SRKFVCFAQN SIGNTTRTIR LRKKEGVVFL YILLGMTVML VGVLVAAALL YWHWIEVVLL CRTFKNKDET LRDKKEFDAF VSYANWSSPE TEATGSLSEE HLALNLFPEV LENTYGYSLC LFERDVTPGG VYTDDIVSII KRSRRGIFIL SPRYINGPRV FELQAAVNLA LVDQTLKLIL IKFCSFQEPE SLPYLVKKAL RVLPTVTWKG LKSVHATSRF WTQIRYHMPV KNSNRFMFNW LRLIPKGFSP EKDLATQKPL GGMPNSGNSH GAQNRTPDAG NRHGAQNLLL SGHQKRC // ID A0A0G2KM01_DANRE Unreviewed; 581 AA. AC A0A0G2KM01; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000133386}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000133386, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000133386, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133386, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000133386} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133386}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CU914164; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7955.ENSDARP00000107821; -. DR PaxDb; A0A0G2KM01; -. DR Ensembl; ENSDART00000171315; ENSDARP00000133386; ENSDARG00000104832. DR GeneTree; ENSGT00760000119006; -. DR OMA; CHISSFC; -. DR OrthoDB; EOG091G023M; -. DR Reactome; R-DRE-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-DRE-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-DRE-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-DRE-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-DRE-975155; MyD88 dependent cascade initiated on endosome. DR Proteomes; UP000000437; Chromosome 9. DR Bgee; ENSDARG00000104832; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 369 394 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 418 565 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 581 AA; 67404 MW; 405DAB30745AEFE7 CRC64; MPLMSEPLYP FDAPKNLVKL ECYNTGRVLD LSRNNLFLIS PEQFDTYGNI SCLNLSRNGF STAPNGSEFT SLPNLKYLDL SFNKVDLAYD NAFRELQSLE VLDISYNSHY FTVAGVTHNM MFLQYLPSLK VLNMSFNSIN TLTTKTMSSK SLRELQFRGN KLGRMWRDKD NTYVKIFKNF TNLTHLDISN NSIGKIPYTV YTQLPITIQR LQMSHNQLAN INWTMLRRFQ NLRELILHDN NIIEIASNLS VDVPSLELLN LQRNRISKLA IGFLQGVVNL KELDLSYNYL ITVNQSTFPT ESDLKMLWLH GNPFHCTCNL LEFVLWILDT NVKIPRLVTG VTCTMPEERK GLAVIKFDIQ ECIDDQLAFV AYFISAACII CTTFAAITMH LFYWDVSYLY YYLKARFTGY QQLSSESCIY DAFITYDTKD PQVSDWVLNH LRVQLEERSE LFLPICLEER DWIPGSPVLD SLTQSIQNSR KTVFVLTEGY VNSGSFKLAV FLAHQRLLEE NEDVIVLLLL EPVLQYSHFV RLRRRLCARS ILEWPHSSSA EAWFWQSLRN AIRVDNQALY SELYSRYFTT K // ID A0A0P6CK87_9CRUS Unreviewed; 1090 AA. AC A0A0P6CK87; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Protein toll {ECO:0000313|EMBL:KZS07114.1}; DE SubName: Full=Toll receptor {ECO:0000313|EMBL:JAN04711.1}; GN ORFNames=APZ42_029285 {ECO:0000313|EMBL:KZS07114.1}; OS Daphnia magna. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda; OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia. OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAN04711.1}; RN [1] {ECO:0000313|EMBL:JAJ42037.1} RP NUCLEOTIDE SEQUENCE. RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.; RT "Daphnia magna gene sets from two clonal populations assembled and RT annotated with EvidentialGene."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:JAN04711.1} RP NUCLEOTIDE SEQUENCE. RA Gilbert D.G.; RT "EvidentialGene: Evidence-directed Construction of Complete mRNA RT Transcriptomes without Genomes."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:JAJ42037.1} RP NUCLEOTIDE SEQUENCE. RA Millard Andrew; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:KZS07114.1, ECO:0000313|Proteomes:UP000076858} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS07114.1, RC ECO:0000313|Proteomes:UP000076858}; RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS07114.1}; RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.; RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes."; RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; GDIP01181365; JAJ42037.1; -; Transcribed_RNA. DR EMBL; GDIQ01093222; JAL58504.1; -; Transcribed_RNA. DR EMBL; GDIQ01090026; JAN04711.1; -; Transcribed_RNA. DR EMBL; GDIQ01063092; JAN31645.1; -; Transcribed_RNA. DR EMBL; LRGB01002568; KZS07114.1; -; Genomic_DNA. DR Proteomes; UP000076858; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 14. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000076858}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:JAN04711.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000076858}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 1090 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013463343. FT TRANSMEM 820 840 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 870 1012 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1090 AA; 124626 MW; 867882C990F3B9D7 CRC64; MFRLFLLCCV LIQSAVIGQE LGAIVNQHSE NLWKCSSSYH PECRCFPLEN GDFNLQCSIG EDYFTASYVV KEGSISSFVI ECPCNETNPL TDSVYTYLKG IPTSNISILK FNFCPLPKES LSTFFDGHLN LSFIQQISLR SCTPIPTLHH GSFRKISQLA NLYLQNNQLE FLPDDLFEDQ LNLKILWLEK NKLEKINQHI FKNLHLLRSL QLGSNKITQL DFGALSNLQN LLQLNLQNNF LDSVPSHVLQ SLVNLTYLDL SNNKLTNLDK DAFEFNGKLT ELFLRNNSLE ELPEGIFRNN KMLKKLSLQL NTKLSRIRLG VFNNLESLLD LDLSNCSFNE FSFDKHAFTN LTQLTTLNLA RNKLTGLNPD WFVGLASLTH LDLSWNLIPT IENQAFTSLR LLNTLKLNGN LLVRIEANIF QGVGALKNLY LEDNQLEIIQ PESMRHLAEL TVINLARNRL KFDEGLVNPL DGWRQSPLQH NLKLESIDLS RNQIADLYSD WSFMKFLSRL ILSHNLLTTL EFNDIASLSP QRDFSIDLRH NQIAHVNFKS ANSIDGRSDD EKLEESAVKK RIFLDDNPLV CDCNVYFMAQ YMNRSMPGAR HSWKIIAPKL TCQEPATLTG IAPTSVLPRQ LVCKCKGNYL CGCYERPVDR TLLFECQQKN LTGIPTHLPQ LGGYDIQLNL SSNSVNIGQI NENALNSCAD VTVLDLSYNG MDSSVFTSLS WAQNLHLRYP RLRRLDLSHN NFSHIPIGVV DAWNGTQKLT YNLGGNPWRC DCSNLALLKF IYGSWKRVED FHQMMCANGL LISELSIEKL CPSAIAATKY LTIAMPLLAL LVFFICLLFY RCRRVILAWL YNRQLCLWCV VKEEEENDER MYDAFISFSH LDEKFVNEHL VPQLERPPLG LPHYRLCLHS RDWLAGEWIP DQIVRSVATS KRTIVVLTEN FLDSFWGKLE FRTAYHQVLK DKRMRLIIIV KGELPPKDKM DQELQTYLSL NTYLKWDDPF FLDRLRYALP HKKNTLTPGL NITQAIKEHA DSVGKETANG IKPNLLPPLP LLTDRERQKA HVILPPDIEM SLTPTSSASS TVPFFPTSPK // ID A0A0P7YMH8_9TELE Unreviewed; 555 AA. AC A0A0P7YMH8; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 7. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPP69031.1}; GN ORFNames=Z043_112241 {ECO:0000313|EMBL:KPP69031.1}; OS Scleropages formosus (Asian bonytongue). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala; OC Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages. OX NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP69031.1, ECO:0000313|Proteomes:UP000034805}; RN [1] {ECO:0000313|EMBL:KPP69031.1, ECO:0000313|Proteomes:UP000034805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Aro1 {ECO:0000313|EMBL:KPP69031.1}; RA Tan M.H., Gan H.M., Croft L.J., Austin C.M.; RT "The genome of the Asian arowana (Scleropages formosus)."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KPP69031.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JARO02004157; KPP69031.1; -; Genomic_DNA. DR Proteomes; UP000034805; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000034805}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000034805}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 309 329 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 19 76 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 98 183 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 353 528 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 555 AA; 63066 MW; 62C96067C88EA7D4 CRC64; MENCIDHGVH FQPVFTVPGE AAMLSCTLDH NSPYNISWFK EGTERELSDN EGKIMVRAKE LWFLNSDLQD AGNYVCILRT HDQCWRETLV LIVNNINPEY CGRPQKTEQE LTVIANGYLS CPLFSYMEHV DSYSFQWFKG GKFKYVRHLL LIQHVSSNDM GYYTCRMTFN LTGTTAHVSE TISCEIIDQW NLLPAVVEPI NDLVKAEYGS PFTKVCRVFV PGEGENMVHV HWAAEDFISW NSSQRVNQVS LNRSKVEDGE WMEVVLHFTE VEKEDFYHTY RCMVFNEYGL ITGNFTLLPS DPNYLPHQGL FFCLLILIFI TAIGTWRVFR VDLVLCCRTY CARLYKDPAR DGKVYDAYVA YLRSCEGEDC RGGACGAVEE FALCVLPQVM EGEWGYRLFI LGRDSFPGEA IADAVQRNIQ RSRRLLLLYS ASSFSHPDAT LHLEQQLATH GALVEGGMRV ILVELGEAVN DALLPESVRY LRSRQGALCW RGAQSEQGCL MRLRSNSLVS HISGHQEAPL SSASFWSRSQ RGTGESQQQQ PQSHVGDPPE VQPHN // ID A0A0Q3M3E6_AMAAE Unreviewed; 469 AA. AC A0A0Q3M3E6; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 7. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:KQK77199.1}; GN ORFNames=AAES_239402 {ECO:0000313|EMBL:KQK77199.1}; OS Amazona aestiva (Blue-fronted Amazon parrot). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona. OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK77199.1, ECO:0000313|Proteomes:UP000051836}; RN [1] {ECO:0000313|EMBL:KQK77199.1, ECO:0000313|Proteomes:UP000051836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK77199.1}; RA Millard Andrew; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KQK77199.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LMAW01002778; KQK77199.1; -; Genomic_DNA. DR Proteomes; UP000051836; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000051836}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KQK77199.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000051836}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 127 151 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 12 123 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 176 335 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 469 AA; 53582 MW; 04145B8F9B28D39B CRC64; MGFQEGVLTI APQGVETGAA VVFEEGFCPL PEGSSANLTC RAFFGYSGDV SPLIYWMKGE KFIEDLDDSR VWESDIRVLK EHLGEQEVSI SLILDSVEEA DLGNYSCYVE NGNGRRHASI LLHKRELMYT VELAGGLGAI LLLLVCLVTI YKCYKIEIML FYRNHFGAEE LDGDNKDYDA YLSYTKVDPD QWNQETGEEE RFALEILPDM LEKHYGYKLF IPDRDLIPTG TYIEDVARXV DQSKRLIIVM TPNYVVRRGW SIFELETRLR NMLVTGEIKV ILIECSELRG VMNYQEVEAL KHTIKLLTVI KWQGPKCNKL NSKFWKRLQY EMPFKRIEPI THEQVLDVSE QGPFGELQTV SAISMAAATS TALATAHPDL RSTFHNTYHS QMRQKHYYRS YEYDVPPTGT LPLTSIGNQH TYCNIPMTLI NGQRPQTKTN REQNPEEAHT NSAILPLLPR ETSISSVIW // ID A0A0Q3M4E9_AMAAE Unreviewed; 587 AA. AC A0A0Q3M4E9; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 6. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:KQK77527.1}; GN ORFNames=AAES_125076 {ECO:0000313|EMBL:KQK77527.1}; OS Amazona aestiva (Blue-fronted Amazon parrot). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona. OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK77527.1, ECO:0000313|Proteomes:UP000051836}; RN [1] {ECO:0000313|EMBL:KQK77527.1, ECO:0000313|Proteomes:UP000051836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK77527.1}; RA Millard Andrew; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KQK77527.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LMAW01002746; KQK77527.1; -; Genomic_DNA. DR Proteomes; UP000051836; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000051836}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KQK77527.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000051836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 363 386 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 57 129 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 134 224 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 259 357 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 410 564 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 587 AA; 67468 MW; 0FD56678D3AB4520 CRC64; MILKENISEY QPKLIKKILL TLCWILALFV NGAEVREVNF LGCSHVEPQI WYRAISGEEF VLQCALPDRD ATHIYNNSLP KQRKVKWFWQ KDKEPLXAIX ESSNSALQGD ALWFKPVRDS DSGMFICMIW GKIPCLKIVL EVQTKKLAKC SGYDTSMLYL LAGNGNSITC PGTKCYSHXK KPEVKWYKDG HQIKQKKTRK SLKLKHNEIY MNPTYDKDAG IYVCDYVLYD NTTKWXMRTT VTVEVIAKNT IHPPNLLYPN GVMILEAELG KPLELECRVQ FGFERPSLMR VTWKRNNKEN INEKLNQETR VYQEGLKGHT ILHVAKLKEV TERDLGSNFT CFAENSVGNA TAVIQLKRKQ RVFLLHVLCS AISILFALLL CSAFIYHHWI EIVLMYRSYL VHNETTGDGK EFDAFVSYAK LDSSESDSTL ISEEKFALEL LPDMLENKYG YKLCILERDI LPGGAYTDEV VTAIKQSRRV IIILSPAYVS GPSIFELQAA VNCALEDKKI KLVLIKFQAF QEPETLHPVV KKALRILPVI TWKSSVSAAP NKFWKYMRYH MPVKTTKMLG NWSLKDFCLR LLSLVYR // ID A0A0Q3M749_AMAAE Unreviewed; 867 AA. AC A0A0Q3M749; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 25-OCT-2017, entry version 7. DE SubName: Full=Interleukin-1 receptor accessory protein {ECO:0000313|EMBL:KQK78192.1}; GN ORFNames=AAES_117015 {ECO:0000313|EMBL:KQK78192.1}; OS Amazona aestiva (Blue-fronted Amazon parrot). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona. OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK78192.1, ECO:0000313|Proteomes:UP000051836}; RN [1] {ECO:0000313|EMBL:KQK78192.1, ECO:0000313|Proteomes:UP000051836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK78192.1}; RA Millard Andrew; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KQK78192.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LMAW01002683; KQK78192.1; -; Genomic_DNA. DR Proteomes; UP000051836; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 3. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 2. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 2. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000051836}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KQK78192.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000051836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 399 419 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 97 184 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 294 384 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 439 585 TIR. {ECO:0000259|PROSITE:PS50104}. FT DOMAIN 601 696 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 867 AA; 98263 MW; CE41A9F0BA0B2266 CRC64; MPLLGKLLLG LRVPGXSCER QMKMVSVMLV ALWLWMVALV SGSEALRHWF CPSDSGSKVL DVTSASRVRW WLELRSSDCK RCDDWGVDTM KQIQIYEGEP AKIKCPLFET FLKYNYSTAH SAGLTLIWYR IAQDRDLEEP INFRLPDNHI SKEKDTLWFW PALLNDTGNY TCMLRNTTYC SKVAFPLEVV PKDQHSCVSX SIKPFEEMFY LEHTNEIICP DIDGFYPASV TPTVKWYLNC NLVDHFYERY PQGPRLVIGI VRSVYRGNYT CIVTFKDHGR TYNLTRTINM KVVGDDLVLS CEVFFTFLKE SRTEVWWTID EKNTGDITDP KIKVTQSEIT RDFEDKTIIR TLTVAKATPE DLKRNYTCYA RNAKGEDRSQ AIVRMKAVAP KYTVELACGL GATILLIVVL IVIYHVYWLE MVLFYRAHFG TDETILDGKE YDVYVSYARN AEEEEFVLLT LRGVLENEFG YKLCIFDRDS LPGGIVTXET LSFIQKSRRL LVVLSPNYVL QGTQALLELK AGLENMASKG NIKVILVQYK AIKKSTVKEL KKAMAALTVI KWKGEKSKFP KGRFWNQLWV EMPVEKLSRS LSLDRLINTT EAVFDFIQRS RRMIVVLSPD YLTEKSISLL EFKLGIMCQN AIATKLIVVE YRPLQCTHPS ILQLKESVSF VTWKGEKSKR SGSQFWKALR LALPLRSLNA GTGWNESCSS QSDISLDPIQ RKRSRLKGQP NPRGATAVTL APGGAATAPK SKVRHQAKHF LTCRCCGTYC NGGSRLKRKH RAATEHRWDT QLCKSGSGRP TAQGIQSRSR PDPPSAQAPG LALCHYSDLS NNNDFYVLSQ VADGTAGCAV VFASFSVITN GSEIQFS // ID A0A0Q3U2Z6_AMAAE Unreviewed; 1041 AA. AC A0A0Q3U2Z6; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 28-MAR-2018, entry version 16. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KQL60561.1}; GN ORFNames=AAES_05831 {ECO:0000313|EMBL:KQL60561.1}; OS Amazona aestiva (Blue-fronted Amazon parrot). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona. OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQL60561.1, ECO:0000313|Proteomes:UP000051836}; RN [1] {ECO:0000313|EMBL:KQL60561.1, ECO:0000313|Proteomes:UP000051836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQL60561.1}; RA Millard Andrew; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KQL60561.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; LMAW01000123; KQL60561.1; -; Genomic_DNA. DR Proteomes; UP000051836; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000051836}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:KQL60561.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000051836}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 1041 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5006208228. FT DOMAIN 881 1028 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1041 AA; 119526 MW; E2EDBEB2D40FBF10 CRC64; MSNALPFVLL FPFPMLLSGT WFPKSLPCDV NTFEGTVTVD CTNRRLLEVP RGIPANATNL TLSINHIPHV NPASFAHLVN LVEIDFRCNC VPVRMGPKDH VCTTQPKIEN GSFAALTRLK SLYLDANQLR EIPWGLPTTL SLLSLEANHI FSIQKANLSE LGNIEVLYLG QNCYYRNPCN VSFEIEKTAF LELKKLTILS LKSNNLTHIP PNLSSTLKEL YIYNNKIQVI QEHDLSTLHN LEILDLSGNC PRCYNAPYPC IPCPNSTIEI HSKAFYSLKN LRILRLHSNS IQSIPSSWFK NLRNLKQLDL SQNFLIKEIG DAQFLKFIPS LVELDLSFNF QLKTYSSTLN LSKSFSSLSN LETLRLRGYV FKELSEGNLD PLLSLRNLTV LDLGTNFIKV VDLSVFKKFP SLKLIDLSVN KISPSSGESN FHGFCSNPRI SVEQYNRQVL EEMHYFRYDE YGRSCRSKDK EAADYQSAVK KDCLEYGETM DLSRNNIFFI NPSDFQGLSY LRCLNLSGNA ISQTLNGSEF SYLSGLKYLD FSNNRIDXLY STAFKELKLL EILDLSNNKH YFLAEGVTHM LSFMKNLAHL KKLMMNENEI STSTNTGMES QSLQILEFRG NRLDVLWMDG NARYLSFFKN LTVLEELDIS XNSLSFLPHG VFEAMPPELK ILNLTNNRMK SFQWKSLHHL KKLETLDLSN NLLATVPQEL SNCSSTVQNL ILRNNHIQRL SKHFLRGAFK LKYLDLSSNK IQIIKKSSFP ENVINNLKML LLHGNPFKCN CXAVWFVWWI NQTQVTIPLL ATDVTCAGPG AHKGKSVVFL DLYTCELDTS YLILYALSAS TVLGFMVFTV MSHLYFWDVW YSYHYCSAKW KGYRHLPLPD ACYDAFIAYD NEDPAVNEWV MEELVERLED QKARQFNLCL EGRDWLPGQP VFDNLSQSIQ LSKKTIFVLT NKYIKSGNFK TTFYMAHQRL LDEKIDVIIL IFLEKVLQKS RYVQLRKRLC RSSVLEWPNN PRSQPYFWQC LKNAIAMNNT LAYNKLLQET V // ID A0A151NN29_ALLMI Unreviewed; 593 AA. AC A0A151NN29; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 5. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 isoform A {ECO:0000313|EMBL:KYO38198.1}; GN Name=IL1RAPL2 {ECO:0000313|EMBL:KYO38198.1}; GN ORFNames=Y1Q_0015489 {ECO:0000313|EMBL:KYO38198.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38198.1}; RN [1] {ECO:0000313|EMBL:KYO38198.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38198.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO38198.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AKHW03002524; KYO38198.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KYO38198.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 264 282 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 67 139 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 146 254 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 307 466 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 593 AA; 68121 MW; BC52EE2799725FF1 CRC64; MSKDEDSIWF HSVELQDSGF YTCVLRNSTY CMKVSMSLTV ADNESGLCYN SQIRYLEKSE VTKRKIISCP DIDDYKISNQ EPDVVWYKEC KPKMWRSIVI QKGNTLLIQE VQEEDGGNYT CELKFEGKLI RRTTQLKVTA LLTDKPPKPL FPMENQPTVI DVQLGNPLTV PCKAFFGFSG ESRPVIYWMK GEKFIEELEG HIREGEARLL KEHLGEKEVQ LMLIFDAVEE ADLANYTCHV ENRNGHKHAS VLLRKKDLIY KIELAGGLGA ILLLFVLLVT IYKCYNIELM LFYRQNFGGD EAADDNKEYD AYLSYTKVDP DALDCENNEE EQFALEILPD VLEKHYGYKL FIPDRDLIPS GTYIEDLTRC VEQSRRLIIV LTPDYVLRRG WSIFEMENRL HNMLVSGEIK VILIECTELK GKVNYHEVES LKHTIKLLSV VKWKGPKSSK LNSKFWKHLV FEMPAKKKEV VSRRQVLDSA EQGLFGDLQT VPSIAVTGAS ATLVESQADL ADYHQTDSMQ MRHYCRGYEY DVSAATLPLA SISNHHTYCN IPLTLLNGQL PLNNTMKDNQ EFHRNNPLLP LSSRELSFTS DIW // ID A0A151NX74_ALLMI Unreviewed; 1039 AA. AC A0A151NX74; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 25-OCT-2017, entry version 6. DE SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|EMBL:KYO41398.1}; GN Name=IL1R1 {ECO:0000313|EMBL:KYO41398.1}; GN ORFNames=Y1Q_0006221 {ECO:0000313|EMBL:KYO41398.1}; OS Alligator mississippiensis (American alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO41398.1}; RN [1] {ECO:0000313|EMBL:KYO41398.1, ECO:0000313|Proteomes:UP000050525} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO41398.1}; RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415; RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., RA Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A., RA Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D., RA Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J., RA Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y., RA Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E., RA Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J., RA Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W., RA Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D., RA Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.; RT "Sequencing three crocodilian genomes to illuminate the evolution of RT archosaurs and amniotes."; RL Genome Biol. 13:415-415(2012). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:KYO41398.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AKHW03001628; KYO41398.1; -; Genomic_DNA. DR Proteomes; UP000050525; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 6. DR Gene3D; 3.40.50.10140; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 2. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 6. DR SMART; SM00408; IGc2; 5. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 6. DR SUPFAM; SSF52200; SSF52200; 2. DR PROSITE; PS50835; IG_LIKE; 5. DR PROSITE; PS50104; TIR; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000050525}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:KYO41398.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000050525}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 1039 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007586457. FT TRANSMEM 338 360 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 803 825 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 112 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 140 216 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 384 453 TIR. {ECO:0000259|PROSITE:PS50104}. FT DOMAIN 505 584 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 629 679 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 700 792 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 849 1007 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1039 AA; 120164 MW; CF3EFA4D2FF74703 CRC64; MKTKQNMNSL LWFICYLMLF VSPYSTEGCK TCRHFVLKGE PVAISCPTFY TDYNLTWYRN GSDIPVSTER HSRVHQRENF LWFIPANLED SGFYACNIRK ANSSDKKYVQ LSVFKNDNDL CFNETTRFDQ KVFTLTAGKI TCPLLEYFKD ENNTASEIQW YKECMPGLLE DTRFQPLKGE PYLTIKNVTL QDKGNYTCLT TYMHMGKFYN VSRTINLDVE ETPVKKKPEF IYPNNNTIKV DFGSHVVIDC NVSSGIDGLT PYWQVNNSDV DSFDNTYKEE FYEKQSSHGL LIAGAKFNIS KVTNKDYLYK FFCHVFYPHG HTTVYIKLEH PVPNIHGYLI GGGISLVFVI VLAVLIYKLF KIDIVLWYRK SCHIFLFKKV SDGKLYDAYV LYPKNQVSCI YSPDIFALKM LPEVLERQCG YNLFILGRDD LPGEAVINVV DETIHQTHLD TLINGAGAKE YNIMDTDLFA CSISLVFLFL VKTEECQIYD LSEQHNQSSI FVPTGQPLAT DCLLGNVLNL QQVKKNLTWY RSGEKMPVTK NKHSRVHQEE NVLWFMPATL EDSGSYECIV ENVTSCNKIY LNINVFKTAN GLCYNKKFSY TQYILKSSTA SIVCPDLYYF RDKKNIWPVH WLKECNLFED KRFLPQRDEL IITNVSGKDA GNYLCQATYN YMGKQYNVSR NIYVTVVENP AKKNTEILYP RNNTIEVKLG SSLIIDCNVS SFKDYSIAIS WKFNNSLVNY FFNERIREED QEDSFFADHM FSILRLNITE VKHEDYGHHF VCRAGKVSAY IVLQRPARNI QRYLIGGFLS LVFLIVVAIL IYKLLKIDIV LWYRKSCGPF LNKEVSDGKI YDAYVLYPKS SKVTCSCVTD SFVLRVLPEV LERQCGYTLF IFGRDDLPGK AVVNVVDETI KESRRLIIVL EPKTSSYNLL EDSPEEQLVL YNALIRDGIK VILIELAKTI DYTNMPESIK YIKQKHGAIQ WEGDITQKSY LTSTRFWKKV QYRMPPRYSA SSELPLRPVT LNTPFRQDKD EACHFNDSG // ID A0A154PE74_9HYME Unreviewed; 1222 AA. AC A0A154PE74; DT 08-JUN-2016, integrated into UniProtKB/TrEMBL. DT 08-JUN-2016, sequence version 1. DT 28-MAR-2018, entry version 12. DE SubName: Full=Protein toll {ECO:0000313|EMBL:KZC09578.1}; GN ORFNames=WN55_00250 {ECO:0000313|EMBL:KZC09578.1}; OS Dufourea novaeangliae. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata; OC Apoidea; Halictidae; Rophitinae; Dufourea. OX NCBI_TaxID=178035 {ECO:0000313|EMBL:KZC09578.1, ECO:0000313|Proteomes:UP000076502}; RN [1] {ECO:0000313|EMBL:KZC09578.1, ECO:0000313|Proteomes:UP000076502} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=0120121106 {ECO:0000313|EMBL:KZC09578.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:KZC09578.1}; RA Pan H., Kapheim K.; RT "The genome of Dufourea novaeangliae."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KQ434870; KZC09578.1; -; Genomic_DNA. DR RefSeq; XP_015431338.1; XM_015575852.1. DR GeneID; 107187700; -. DR Proteomes; UP000076502; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 7. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 23. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000076502}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000076502}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 12 33 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1009 1032 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1062 1197 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1222 AA; 137666 MW; CEA980DE70502C66 CRC64; MRCLVGPDGL RRSVLLVSLA CYYCLLVPVY HVLAVTSELP PRLDLPEHCS WDSRQDGAIT CIHRYAGGGG YVGSLKTNFS QATSEYVTSV NVVCEDTDTL ENGVLNVDGF VQLWRLRSLR LTGCKLVHWP TKVLSGLRDL RNLTVRSLNG RKSKYSLELE SGAFDSVPQI EKIDLSWNNI WQIPEHLFCP LSNLLTLNVS WNMLKDITEL GFRDTLERHP RRQLESTPAP FPCSLDMQSL DVSNNQISVL PTHGFSSLKR LKVLNLSSNA IGMVADEALH GLRSLETFDL SGNRIVALPA EMFRDAAKSL KELRLQNNSI SVLSPGLVAD MNQLVALDLS RNALTSSWLN SATFSGLIRL VLLNLSHNRI SKLDPALFKD LYTLQILNLQ YNEIETIPAD TFAPMSNLHT LDLAYNRLTY LDAYSLNGLF ALSLLSLDSN QLEGIHPDAF RNCSSMQDLN LSGNNLDSIP VALKDMRMLR TLDLGENQIR SLNRPGFRGM SSLYGLRMIG NEITNVTTED FVELPELQIL NLARNKIESV EDGVFTANPA LQAIRLDSNL LQDMSGIFAS VPDLLWLNMS DNMIVQFDYS YLPEKLQWMD LHKNLIMDLG VAPQGMRLQT LDVSFNRLTR IHSRSIPDSI ELLFVNDNLI QAVEPQTFFD KRNLTRVDLY ANQIVKMNLS AFQLTQVPAY RQLPEFYIGG NPFICDCTTE WLQRINSLPL RQHPRVMDLE SVYCRLPYDR QKSFIPLLEA KPSQFLCTYK AHCFALCHCC DFDACDCEMI CPTNCTCYHD QSWSANVVDC SNSGYRTLPR RLPMDATEVY LDGNNFGEFN SHSFIGRKNL QILYANDSNI IAIRNHTFSG LKRLLVLHLE NNKISVLNGV ELMPLENLKE LYLQNNLLTY IDNGTFLPLR QLEVLRLENN RLGTFAVWQL VQNPYLVDIG LSSNPWSCEC SYLDRVREWM SRNRAKISDW RSVTCSLGMP ITLPTNGSVI NCAALTGTTS VIETRPLEAY LPLLLATAVL IFAMVALVCG AFKHRRALRT WAASRCGLRA CYKTAAFEDQ EKPFDAYISY SAVDEAFVST ILVPGLETSY RLCLHYRDLG AGSNVADAVA EAADSSRRTI LVLSKNFLHG EWARFEFKAA LRDALKGKGR SVILLLVGGV CPRDLDADLR KRISSHTVLV WGDKLFWQKL RFAMPDVSPV PVLERPLPLP PPPPPPVQHQ WT // ID A5H2Z9_RAT Unreviewed; 1050 AA. AC A5H2Z9; DT 12-JUN-2007, integrated into UniProtKB/TrEMBL. DT 12-JUN-2007, sequence version 1. DT 28-MAR-2018, entry version 102. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:ABM92443.1, ECO:0000313|Ensembl:ENSRNOP00000005620}; GN Name=Tlr7 {ECO:0000313|EMBL:ABM92443.1, GN ECO:0000313|Ensembl:ENSRNOP00000005620, ECO:0000313|RGD:1563357}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:ABM92443.1}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000005620, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005620, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|EMBL:ABM92443.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:ABM92443.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:ABM92443.1}; RA Chuang T.-H.; RT "Rattus norvegicus toll-like receptor 7 (TLR7) mRNA."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSRNOP00000005620} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005620}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AABR07037693; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; EF032637; ABM92443.1; -; mRNA. DR RefSeq; NP_001091051.1; NM_001097582.1. DR UniGene; Rn.14819; -. DR STRING; 10116.ENSRNOP00000005620; -. DR Ensembl; ENSRNOT00000005620; ENSRNOP00000005620; ENSRNOG00000004249. DR GeneID; 317468; -. DR KEGG; rno:317468; -. DR CTD; 51284; -. DR RGD; 1563357; Tlr7. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000230468; -. DR HOVERGEN; HBG018601; -. DR KO; K05404; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Reactome; R-RNO-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-RNO-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-RNO-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-RNO-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-RNO-975155; MyD88 dependent cascade initiated on endosome. DR Proteomes; UP000002494; Chromosome X. DR Bgee; ENSRNOG00000004249; -. DR GO; GO:0005737; C:cytoplasm; ISO:RGD. DR GO; GO:0032009; C:early phagosome; ISO:RGD. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD. DR GO; GO:0005768; C:endosome; ISO:RGD. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; ISO:RGD. DR GO; GO:0005886; C:plasma membrane; ISO:RGD. DR GO; GO:0043235; C:receptor complex; ISO:RGD. DR GO; GO:0003725; F:double-stranded RNA binding; ISO:RGD. DR GO; GO:0008144; F:drug binding; IDA:RGD. DR GO; GO:0003727; F:single-stranded RNA binding; ISO:RGD. DR GO; GO:0035197; F:siRNA binding; ISO:RGD. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD. DR GO; GO:0051607; P:defense response to virus; ISO:RGD. DR GO; GO:0007252; P:I-kappaB phosphorylation; ISO:RGD. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0001774; P:microglial cell activation; IDA:RGD. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; ISO:RGD. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; ISO:RGD. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; ISO:RGD. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; ISO:RGD. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; ISO:RGD. DR GO; GO:0001932; P:regulation of protein phosphorylation; ISO:RGD. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; ISO:RGD. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IDA:RGD. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 15. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 22. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:ABM92443.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 841 866 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 890 1037 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1050 AA; 121300 MW; C436DCBBDE69F5AD CRC64; MVFPMWTLKR QSFIFLNMIL VSRVLGFRWY PKTLPCDVSL DSTNTHVIVD CTDKHLTEIP EGIPTNTTNL TLTINHIPSI SPDSFHRLKH LEELDLRCNC VPILLGSKAN VCTKRLQIRP GSFSGLSDLK SLYLDGNQLL EIPQDLPSSL QLLSLEANNI FSITKENLSE LVNIESLYLG QNCYYRNPCN VSYSIEKDAF LVMKNLKVLS LKDNNVTAVP TILPPNLLEL YLYNNIIKRI QEHDFNKLSQ LQVLDLSGNC PRCYNVPYPC TPCENNSPLQ IHDNAFDSLT ELKVLRLHSN SLQHVPAEWF KNMSNLQELD LSQNYLAREI EEAKFLNSLP NLVQLDLSFN YELQVYHASI TLPHSLSSLT KLKNLYIKGY VFKELKDSSL SVLHNLSNLE VLDLGTNFIK IADLNIFQQF ENLKFIDLSV NKISPSEESR EVGLCPNAQT SVDWHGPQVL EALHYFRYDE YARSCRFKNK EPPTFLPLNA DCHTYGKTLD LSRNNIFFIK PSDFKHLSFL KCLNLSGNAI GQTLNGSELQ PLRELRYLDF SNNRLDLLYS TAFEELQNLE ILDLSSNSHY FQAEGITHML NFTKKLRHLE KLMMNDNDIS TSASRTMESE SLRVLEFRGN HLDVLWRDGD NRYLDFFKNL LNLEELDISR NSLNSVPPGV FEGMPPNLTT LSLAKNGLRS FSWGRLQLLK HLKNLDLSHN QLTTVPARLA NCSKSLTKLI LNHNQIRQLT KYFLEDALQL RYLDISSNKI QVIQKTSFPE NVLNNLNMLL LHHNRFLCNC DAVWFVWWVN HTDVTIPYLA TDVTCAGPGA HKGQSVISLD LYTCELDLTN LILFSVSISS VLFLMIVMTT SHLFFWDMWY IYYFWKAKIK GYQHLQSMES CYDAFIVYDT KNSAVTEWVL QELVVKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL SRKTVFVMTQ KYAKTESFKM AFYLSHQRLM DEKVDVIILI FLEKPLQKSK FLQLRKRLCS SSVLEWPTNP QAHPYFWQCL KNALTTDNHV AYSQMFKETV // ID A5H300_RAT Unreviewed; 1029 AA. AC A5H300; DT 12-JUN-2007, integrated into UniProtKB/TrEMBL. DT 12-JUN-2007, sequence version 1. DT 28-MAR-2018, entry version 94. DE SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:ABM92444.1, ECO:0000313|Ensembl:ENSRNOP00000066040}; GN Name=Tlr8 {ECO:0000313|Ensembl:ENSRNOP00000066040, GN ECO:0000313|RGD:1590327}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:ABM92444.1}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000066040, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000066040, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|EMBL:ABM92444.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:ABM92444.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:ABM92444.1}; RA Chuang T.-H.; RT "Rattus norvegicus toll-like receptor 8 (TLR8) mRNA."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ABM92444.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:ABM92444.1}; RC TISSUE=Spleen {ECO:0000313|EMBL:ABM92444.1}; RX PubMed=20004021; DOI=10.1016/j.molimm.2009.11.003; RA Liu J., Xu C., Hsu L.C., Luo Y., Xiang R., Chuang T.H.; RT "A five-amino-acid motif in the undefined region of the TLR8 RT ectodomain is required for species-specific ligand recognition."; RL Mol. Immunol. 47:1083-1090(2010). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000066040} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000066040}; RG Ensembl; RL Submitted (FEB-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AABR07037696; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07037697; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AABR07037698; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; EF032638; ABM92444.1; -; mRNA. DR RefSeq; NP_001094479.1; NM_001101009.1. DR UniGene; Rn.216383; -. DR STRING; 10116.ENSRNOP00000066040; -. DR Ensembl; ENSRNOT00000073535; ENSRNOP00000066040; ENSRNOG00000045992. DR GeneID; 684440; -. DR KEGG; rno:684440; -. DR CTD; 51311; -. DR RGD; 1590327; Tlr8. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOVERGEN; HBG018601; -. DR KO; K10170; -. DR OMA; WPDNPKA; -. DR OrthoDB; EOG091G014D; -. DR Reactome; R-RNO-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-RNO-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-RNO-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-RNO-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-RNO-975155; MyD88 dependent cascade initiated on endosome. DR PRO; PR:A5H300; -. DR Proteomes; UP000002494; Chromosome X. DR Bgee; ENSRNOG00000045992; -. DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0003677; F:DNA binding; ISO:RGD. DR GO; GO:0003725; F:double-stranded RNA binding; ISO:RGD. DR GO; GO:0008144; F:drug binding; IDA:RGD. DR GO; GO:0042802; F:identical protein binding; ISO:RGD. DR GO; GO:0004872; F:receptor activity; IBA:GO_Central. DR GO; GO:0003727; F:single-stranded RNA binding; ISO:RGD. DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD. DR GO; GO:0051607; P:defense response to virus; ISO:RGD. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:RGD. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0001774; P:microglial cell activation; IDA:RGD. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:2001183; P:negative regulation of interleukin-12 secretion; ISO:RGD. DR GO; GO:0045089; P:positive regulation of innate immune response; ISO:RGD. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; ISO:RGD. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; ISO:RGD. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; ISO:RGD. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; ISO:RGD. DR GO; GO:2000778; P:positive regulation of interleukin-6 secretion; ISO:RGD. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; ISO:RGD. DR GO; GO:0001932; P:regulation of protein phosphorylation; ISO:RGD. DR GO; GO:0009615; P:response to virus; ISO:RGD. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; ISO:RGD. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IDA:RGD. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 22. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:ABM92444.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 1029 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014083808. FT TRANSMEM 817 840 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 866 1013 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1029 AA; 119272 MW; C9FAADD3F743F9EA CRC64; MSPQSWILTC FCLLSSGTSA VFLKGNFSRS YPCDEKRHNA LVTAECNHRQ LHEVPQTIGK YVTDVDLSDN TIMHITNESF QKFRNLTKIN LNHNAKQQHP NENKNGMNIT EGAFLSLRNL TELLLEDNQL YTIPAGLPES LKELSLIQNN IFQVTKNNTF GLRNLERLYL GWNCYFKCNQ IFKVEDGAFN NLINLKLLSL SFNNLFSVPP KLPSSLSKLF LSNAKISTIT QEDFKGLEHL ILLDLSGNCP RCFNAPFPCE SCNLSASIRI HPLAFQNLTQ LRFLNLSSTS LRTIPSTWFD NLTNLKELHL EFNYLVQEIA SGAFLTKLPS LQTLDLSFNF IHKEYLQYIT ISPNFSMLRS LRKLHLKGYV FRELKKEHFK PLQNLPNLTT INLGINFIEK IDFKAFQDFP NLKVIYLSGN RIASVIDGTD HSSWRNRLRK PLSTDYDEFD PHMNFYHSTE PLIKPQCTTY GKALDLSLNN IFVIGKSQFE GFQDIACLNL SFNANGQVLN GTEFSSMPHI KYLDLTNNRL DFDDNQTFSD LHDLEVLDLS HNAHYFSIAG VTHRLGFIQN LIKLKVLNLS HNGIYTLTDE YKLQSKSLKE LVFSGNRLDR LWNANDGKYW SIFTSLETLT RLDLSYNNLQ QIPNEAFLNL PQSLQELHIN DNRLRFFNWT LLQYFPHLHV LDLGRNELYF LTNCLSKFTH SLKTLLLNHN HFSHLPAGFL SEARNLVYLD LSFNTIKMIN KSSLQTETKT NLSVLDLQGN HFDCTCDISD FRSWLEENPH VRIPRLVDVI CSNPGDQRWK SVMSLDLTTC VSDTTAAILF FFTFLTTSTV LLAALVHHLF YWDVWFIYHM CSAKLRGYRS SSTSQTFYDA YISYDTKDAS VTDWVINELR YHLEESEDKS VLLCLEERDW DPGLPIIDNL MQSINQSKKT IFVLTKKYAK SWNFKTAFYL ALQRLMDENM DVIIFILLEP VLQYSQYLRL RQRICKSSIL QWPNNPKAEN LFWQSLKNVV LTENDSRYDN LYIDSIRQY // ID A7RG80_NEMVE Unreviewed; 677 AA. AC A7RG80; DT 02-OCT-2007, integrated into UniProtKB/TrEMBL. DT 02-OCT-2007, sequence version 1. DT 25-OCT-2017, entry version 65. DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EDO49483.1}; GN ORFNames=v1g196737 {ECO:0000313|EMBL:EDO49483.1}; OS Nematostella vectensis (Starlet sea anemone). OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; OC Edwardsiidae; Nematostella. OX NCBI_TaxID=45351 {ECO:0000313|Proteomes:UP000001593}; RN [1] {ECO:0000313|EMBL:EDO49483.1, ECO:0000313|Proteomes:UP000001593} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593}; RX PubMed=17615350; DOI=10.1126/science.1139158; RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., RA Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., RA Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., RA Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.; RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and RT genomic organization."; RL Science 317:86-94(2007). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; DS469509; EDO49483.1; -; Genomic_DNA. DR RefSeq; XP_001641546.1; XM_001641496.1. DR ProteinModelPortal; A7RG80; -. DR STRING; 45351.NEMVEDRAFT_v1g196737-PA; -. DR EnsemblMetazoa; EDO49483; EDO49483; NEMVEDRAFT_v1g196737. DR GeneID; 5521764; -. DR KEGG; nve:NEMVE_v1g196737; -. DR eggNOG; KOG0619; Eukaryota. DR eggNOG; KOG4475; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; A7RG80; -. DR OrthoDB; EOG091G024T; -. DR Proteomes; UP000001593; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 4. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 4. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 4. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 4. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001593}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001593}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 484 509 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 21 117 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 136 234 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 239 333 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 339 467 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 530 631 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 677 AA; 75165 MW; 812F0666BEE5BEA0 CRC64; MDRDVTALVI KTWAIFFAAL PVSILLSARD AAGEDIKCQI HSSVAGKPAA TPGQNVVLNC TVAAGRRASR MDWLKHGQGV TEGVTYCLDA RGAGLTCAVL QIVNASAKDA GVYVCEARGK AGWDRSQILL HVFGPPRINI PLTQPGPLRW PLGSRQYLAC EVTGYPAPNI TWLYNNMTVR PGRHDMWHGA YYLNALDHRR LTLNLFAVTR DNQGIYMCRA SNGWGKEELV LNVTVIELPK LAVNSDSQFY VSHRGENSTL TCTVTGIRNG ETITAHWRHG SSASRGRTRT QTLSGGRARL VLFLEDVTAS DGGSYSCGIS SKEGTHATTF LVVVGHGLPG IQATRPRIKT TAGSRCVLNC IVTLPPRTSV ILSWNRNGSL MEWTSRGRQY LRDLSRAEKR TEPLVPLKSV SKLGNAISLG SLGDSSDSRL EFNLEIVNVT EEDKGWYACE LNTTLGSNSS MIYLTVANVS AVGLLPKDSS NFSFAGVLGV IALCSISSCI AAFAVRYLIR RKRFIHLKGS ISSKHLNNKF KYDVFLTFSS KDVDWVIRHL TPLLDKLCLE YCIHTRDFEI GKAISENIAD SVYHSRKVIS IMSYHYMASK YCRAELDVAL YRSTEYDDSS LIVIRVDDIP KAKLPRALRN RTFIDYNDPE ERRHWEKRLV KYLRAGTRCS YFMETAF // ID B1ASU0_MOUSE Unreviewed; 696 AA. AC B1ASU0; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 28-MAR-2018, entry version 101. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|Ensembl:ENSMUSP00000077915}; GN Name=Il1rapl1 {ECO:0000313|Ensembl:ENSMUSP00000077915, GN ECO:0000313|MGI:MGI:2687319}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000077915, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000077915, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077915, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000077915} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000077915}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AL627409; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL672059; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731705; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844869; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844900; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005231; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX088567; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX649618; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX890584; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR538724; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001153875.1; NM_001160403.1. DR UniGene; Mm.121680; -. DR UniGene; Mm.400887; -. DR UniGene; Mm.426143; -. DR Ensembl; ENSMUST00000078875; ENSMUSP00000077915; ENSMUSG00000052372. DR Ensembl; ENSMUST00000113966; ENSMUSP00000109599; ENSMUSG00000052372. DR GeneID; 331461; -. DR KEGG; mmu:331461; -. DR UCSC; uc012hln.1; mouse. DR CTD; 11141; -. DR MGI; MGI:2687319; Il1rapl1. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR HOGENOM; HOG000092977; -. DR HOVERGEN; HBG052148; -. DR KO; K05170; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Reactome; R-MMU-388844; Receptor-type tyrosine-protein phosphatases. DR Reactome; R-MMU-9007892; Interleukin-38 signaling. DR ChiTaRS; Il1rapl1; mouse. DR Proteomes; UP000000589; Chromosome X. DR Bgee; ENSMUSG00000052372; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:B1ASU0, KW ECO:0000213|PeptideAtlas:B1ASU0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 696 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014084698. FT TRANSMEM 360 381 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 6 134 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 162 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 350 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 403 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 696 AA; 79780 MW; A2CA8D897C5569C1 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKAW RPSIVFKRDT LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTVQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LICSVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSNREP NPDEAHTNSA ILPLLPRETS ISSVIW // ID B3XXC2_PIG Unreviewed; 1028 AA. AC B3XXC2; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 82. DE SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:BAG68215.1}; GN Name=TLR8 {ECO:0000313|EMBL:BAG68215.1, GN ECO:0000313|Ensembl:ENSSSCP00000030352}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|EMBL:BAG68215.1}; RN [1] {ECO:0000313|EMBL:BAG68215.1} RP NUCLEOTIDE SEQUENCE. RA Morozumi T., Uenishi H., Awata T.; RT "Molecular cloning and characterization of porcine TLR7 and TLR8."; RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000030352, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000030352, RC ECO:0000313|Proteomes:UP000008227}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSSSCP00000030352} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSSSCP00000031310} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000112; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB291813; BAG68215.1; -; Genomic_DNA. DR RefSeq; XP_005673461.1; XM_005673404.2. DR RefSeq; XP_005673462.1; XM_005673405.2. DR RefSeq; XP_013841347.1; XM_013985893.1. DR RefSeq; XP_013841348.1; XM_013985894.1. DR RefSeq; XP_013841349.1; XM_013985895.1. DR RefSeq; XP_013841350.1; XM_013985896.1. DR UniGene; Ssc.17224; -. DR UniGene; Ssc.39344; -. DR STRING; 9823.ENSSSCP00000030352; -. DR Ensembl; ENSSSCT00000033339; ENSSSCP00000030352; ENSSSCG00000012118. DR Ensembl; ENSSSCT00000033711; ENSSSCP00000030972; ENSSSCG00000012118. DR Ensembl; ENSSSCT00000064062; ENSSSCP00000031310; ENSSSCG00000012118. DR GeneID; 397384; -. DR CTD; 51311; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOVERGEN; HBG018601; -. DR OMA; WPDNPKA; -. DR OrthoDB; EOG091G014D; -. DR TreeFam; TF351113; -. DR Reactome; R-SSC-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-SSC-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-SSC-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-SSC-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-SSC-975155; MyD88 dependent cascade initiated on endosome. DR Proteomes; UP000008227; Chromosome X. DR Bgee; ENSSSCG00000012118; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0003677; F:DNA binding; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0004872; F:receptor activity; IBA:GO_Central. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 15. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:BAG68215.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 1028 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014085070. FT TRANSMEM 816 837 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 867 1014 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1028 AA; 118826 MW; D0E611AD7548E298 CRC64; MTLHFLLLTC LFLLIPDSCE FFTGANYSRS YPCDERKENG SVIAECNNRQ LQEVPRRVGN YVTELDLSDN FIRRITNESF QGLQNLTKIN LNHNAKLWPQ SENGMTITDG AFLNLHHLRE LLLEDNQLRE IPTGLPESLR ELSLIQNKII LLNTKNMFGL RKLESLYLGW NCYFTCNETF IIDEGAFENL TNLKVLSLSF NTLYRVPPKL PSSLTKLYLS NTKIRNINQE DFKGLENLRV LDLSGNCPRC FNAPFPCNPC PGDASIQIHP LAFRYLTELR YLNLSSTSLR RIPATWFENL HHLKVLHLEF NYLMDEIASG EFLAKLPSLE ILDLSYNYEQ KKYPQYINIS HYFANLTSLQ ILHLRAYVFQ ELRKEDFQPL RNLLHLKFIN LGINFIKQID FTIFSEFSNL SIIYLSENRI SPLVNNTGQK NGDRPSFQSH VLKPRSATPK FDPHSNFYHN TKPLIKPQCS RYGKALDLSL NSIFFIGPNQ FEAFKDIACL NLSSNGNGQV LHGSEFSHLP GIKYLDLTNN RLDFDDDAAF SELPLLEVLD LSYNSHYFRI AGVTHRLGFI QNLPQLRVLN LSHNSIFTLT ETYLKSTSLK ELVFSGNRLD LLWNAQDDRY WQIFKNLSTL THLDLSSNNL QHIPSEAFLN LPQTLTELYI SDNRLNFFNW SLLQQFPNLT LLDLSGNELS FLTDSLSKFT TSLQTLILRQ NRISYLPSGL LSEASSLTHL DLSSNQLKMV NISKLHAKTT TNLAILKLDR NPFDCTCDIR DFRKWMDENL KVTIPRLTDV ICASPGDQRG RSIVSLELTT CVSDTIAAII CFFTFFVTST VMLAALAHHW FYWDAWFIYH VCLAKVKGYR SLPTSQTFYD AYVSYDTKDA SVTDWVMNEL RFHLEESEGK NVLLCLEERD WDPGLAIIDN LMQSINQSKK TIFVLTKKYA KNWNFKTAFY LALQRLMDEN MDVIVFILLE PVLQHSQYLR LRQRICKSSI LQWPDNPKAE GLFWQSLKNV VLTENDSRYN SLYVNSIK // ID B3Y669_PANTR Unreviewed; 811 AA. AC B3Y669; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 78. DE SubName: Full=TLR10 isoform 2 {ECO:0000313|EMBL:PNI15879.1}; DE SubName: Full=TLR10 isoform 3 {ECO:0000313|EMBL:PNI15880.1}; DE SubName: Full=TLR10 isoform 4 {ECO:0000313|EMBL:PNI15881.1}; DE SubName: Full=TLR10 isoform 6 {ECO:0000313|EMBL:PNI15883.1}; DE SubName: Full=TLR10 isoform 7 {ECO:0000313|EMBL:PNI15884.1}; DE SubName: Full=TLR10 isoform 8 {ECO:0000313|EMBL:PNI15885.1}; DE SubName: Full=Toll-like receptor 10 {ECO:0000313|EMBL:BAG55078.1}; GN Name=TLR10 {ECO:0000313|EMBL:BAG55078.1, GN ECO:0000313|Ensembl:ENSPTRP00000027515, ECO:0000313|VGNC:VGNC:12858}; GN ORFNames=CK820_G0051790 {ECO:0000313|EMBL:PNI15879.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:BAG55078.1}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000027515, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136134; DOI=10.1038/nature04101; RA Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T., RA Rozen S., Wilson R.K., Page D.C.; RT "Conservation of Y-linked genes during human evolution revealed by RT comparative sequencing in chimpanzee."; RL Nature 437:100-103(2005). RN [3] {ECO:0000313|EMBL:BAG55078.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18810425; DOI=10.1007/s00251-008-0332-0; RA Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., RA Kimura A.; RT "Natural selection in the TLR-related genes in the course of primate RT evolution."; RL Immunogenetics 60:727-735(2008). RN [4] {ECO:0000313|Ensembl:ENSPTRP00000027515} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|EMBL:PNI15879.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI15879.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI15879.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AACZ04033769; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AB445681; BAG55078.1; -; mRNA. DR EMBL; NBAG03000548; PNI15879.1; -; Genomic_DNA. DR EMBL; NBAG03000548; PNI15880.1; -; Genomic_DNA. DR EMBL; NBAG03000548; PNI15881.1; -; Genomic_DNA. DR EMBL; NBAG03000548; PNI15883.1; -; Genomic_DNA. DR EMBL; NBAG03000548; PNI15884.1; -; Genomic_DNA. DR EMBL; NBAG03000548; PNI15885.1; -; Genomic_DNA. DR RefSeq; NP_001123936.1; NM_001130464.1. DR RefSeq; XP_009445751.1; XM_009447476.1. DR UniGene; Ptr.6692; -. DR STRING; 9598.ENSPTRP00000027515; -. DR Ensembl; ENSPTRT00000029820; ENSPTRP00000027515; ENSPTRG00000015984. DR GeneID; 461166; -. DR KEGG; ptr:461166; -. DR CTD; 81793; -. DR VGNC; VGNC:12858; TLR10. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000008676; -. DR HOVERGEN; HBG023180; -. DR KO; K10171; -. DR OMA; AYLEWPK; -. DR OrthoDB; EOG091G0356; -. DR TreeFam; TF351113; -. DR Proteomes; UP000002277; Chromosome 4. DR Bgee; ENSPTRG00000015984; -. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; IEA:InterPro. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027182; TLR10. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF23; PTHR24365:SF23; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 4. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 9. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:BAG55078.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 811 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014085080. FT TRANSMEM 577 599 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 632 778 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 811 AA; 94584 MW; 6F7BA145E0C62CED CRC64; MRLIRNIYIF CSIVMTVEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLSHY EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSILLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNKIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SILNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVS ATREMYELQT FTELNEESRG STISLMRTDC L // ID B4GD91_DROPE Unreviewed; 1425 AA. AC B4GD91; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 72. DE SubName: Full=GL10362 {ECO:0000313|EMBL:EDW32586.1}; GN Name=Dper\GL10362 {ECO:0000313|EMBL:EDW32586.1}; GN ORFNames=Dper_GL10362 {ECO:0000313|EMBL:EDW32586.1}, GN GL10362 {ECO:0000313|FlyBase:FBgn0147972}; OS Drosophila persimilis (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744}; RN [1] {ECO:0000313|EMBL:EDW32586.1, ECO:0000313|Proteomes:UP000008744} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MSH-3 / Tucson 14011-0111.49 RC {ECO:0000313|Proteomes:UP000008744}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CH479181; EDW32586.1; -; Genomic_DNA. DR RefSeq; XP_002016696.1; XM_002016660.1. DR ProteinModelPortal; B4GD91; -. DR EnsemblMetazoa; FBtr0175977; FBpp0174469; FBgn0147972. DR GeneID; 6590565; -. DR KEGG; dpe:Dper_GL10362; -. DR FlyBase; FBgn0147972; Dper\GL10362. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B4GD91; -. DR Proteomes; UP000008744; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 6. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008744}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000008744}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 1425 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002806751. FT TRANSMEM 1052 1075 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1101 1241 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1425 AA; 159165 MW; 750EB0CB9465D1C7 CRC64; MEFPLLLPLV SVLLLGSASD WSCLAALAPK ESGDNSASAM LGGGAGSASV SLSGDYSSLL SAAMPPASAD DSSPAAPAHS GPSNQCSWTY NGTSSVHCAL RLIERQPGLD LQGADGSSQL TIQCSDLYLF ESTLPVAVFA RLQTLETLRL EACKLLQLPN NAFEGLGTLK TLRLSSHNAE WGPARALELY PDSLNGLKQL TELDMSDNNL RALPAGFLCP VGNLQALNLT HNRIRTAEQL GFADMNCSGG SELQLLDASH NELRSITESW GISRLRRLQH LNLQHNNISE LSGEALAGLA SLRIVNLSNN HLETLPEGLF AGSKELREIH LQHNELYELP KGLFHRLEQL LVVDLSGNQL TSNHVDNTTF AGLIRLIVLN LAHNALTRID YRTFKELYFL QILNLRNNSI GHIEDNAFLP LYNLHTLNLA ENRLHTLDDK LFNGLYVLSK LTLNNNLISV VEQAVFKNCS DLKELDLSSN QLNEVPRALQ DLAMLRTLDL GENQIRTFDN QSFKNLHQLT GLRLIDNQIG NITVGMFQDL PRLSVLNLAK NRIQSIERGS FDKNFELEAI RLDRNFLSDI NGVFATLVSL LWLNLSENHL VWFDYAFIPS NLKWLDIHGN YIEALGNYYK LQEEIRVKTL DASHNRITEI GPMSIPNTIE LLFINNNLIG NVQPNAFVDK ANLARVDLYA NQLSKLQLQQ LRVAPVVAPK ALPEFYLGGN PFECDCTMDW LQRINNLTTR QHPRVMDMPN IECVMPHARG AAVRPLSALK PQDFLCRYES HCFALCHCCD FDACDCEMTC PHNCTCYHDQ IWSTNVVDCG GQQTMELPRR VPMDSSIVYL DGNNFPVLKN HAFIGRKNLK ALYVNGSQVA AIQNRTFASL TSLQILQLAD NRLQTLHGYE FEQLSSLREL YLQNNLLATI ENATLSPLVS LELLRIDGNR LVTLPIWQLH ATHFGRRLRS IALGRNQWSC RCQFLQALTS YVAENALIVQ DAQDIYCMAA PNTAGYDAAS YDSSSSEGSL QKRELDFNST GAACTDYYSG GSMLQHGIPE SYIPLLAAAL ALVFLLVVII IVFIFRESLR IWLFAHYGVR VFGPRCEESE KLYDAVLLHS AKDSEFVCQH LASELETGRP PLRVCLQHRD LAHDATHYQL LEATRVSRRV VILLTRNFLQ TEWSRCELRR SVHDALRGRP QKLVIIEEPE VAFEAESDIE LLPYLKTSAV HRIRRSDRHF WEKLRYALPA DYPTYRGNNY TLDHNHERQR EAPPAPPQLQ PSRTIPTATT ATPSPRPQRR GDHHGGVSGS GAAAAPHGHH LHAQYYQHHG MRPPSEHIYS SIDSDYSTLD NEQHMLMMPA GPVVSLEGTP RAQTWRPKQQ QQQQPGLQSG PSSVGHVATM GPSGKTPPQQ QQQQQQQQAV GSGQQQGPHV QAYLV // ID B4HPS5_DROSE Unreviewed; 1444 AA. AC B4HPS5; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 69. DE SubName: Full=GM21984 {ECO:0000313|EMBL:EDW48643.1}; GN Name=Dsec\GM21984 {ECO:0000313|EMBL:EDW48643.1}; GN ORFNames=Dsec_GM21984 {ECO:0000313|EMBL:EDW48643.1}, GN GM21984 {ECO:0000313|FlyBase:FBgn0176861}; OS Drosophila sechellia (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292}; RN [1] {ECO:0000313|EMBL:EDW48643.1, ECO:0000313|Proteomes:UP000001292} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Rob3c / Tucson 14021-0248.25 RC {ECO:0000313|Proteomes:UP000001292}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CH480816; EDW48643.1; -; Genomic_DNA. DR RefSeq; XP_002034630.1; XM_002034594.1. DR ProteinModelPortal; B4HPS5; -. DR EnsemblMetazoa; FBtr0204969; FBpp0203461; FBgn0176861. DR GeneID; 6610010; -. DR KEGG; dse:Dsec_GM21984; -. DR FlyBase; FBgn0176861; Dsec\GM21984. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B4HPS5; -. DR Proteomes; UP000001292; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 20. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 23. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001292}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001292}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 1444 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002809017. FT TRANSMEM 1047 1070 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1096 1236 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1444 AA; 160761 MW; 0C659E07B1165969 CRC64; MAAILLLLLG FSWSLAVESA LAPKESESSA SAMLGAGTGA AATVSLSGDY SSLLSNVPAA LPVPANPSQH SGPANQCSWS YNGTSSVHCA LRLIERQPGL DLQGADGSSQ LTIQCSELYL FESTLPVAVF ARLQTLEALR LDSCKLLQLP NNAFEGLATL KSLRLSTRNS EWGPTRTLEL FPDSLGGLKQ LTDLDLGDNN LRQLPSGFLC PVGNLQVLNL TRNRIRTAEQ LGFADMNCGA GSGSAGSELQ VLDASHNELR SISESWGISR LRRLQHLNLA YNNISELSGE ALAGLASLRI VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD LSGNQLTSNH VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN LRNNSIGHIE DNAFLPLYNL HTLNLAENRL HTLDDKLFNG LYVLSKLTLN NNLISVVEPA VFKNCSDLKE LDLSSNQLNE VPRALQDLAM LRTLDLGENQ IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFQDLPRLS VLNLAKNRIQ SIERGSFDKN FELEAIRLDR NFLADINGVF ATLVSLLWLN LSENHLVWFD YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS IPNTIELLFI NNNLIGNVQP NAFVDKANLA RVDLYANQLS KLQLQQLRVA PVVAPKPLPE FYLGGNPFEC DCTMDWLQRI NNLTTRQHPR VMDMANIECV MPHARGAAVR PLSGLRPQDF LCRYESHCFA LCHCCDFDAC DCEMTCPSNC TCYHDQIWST NVVDCGGQQT TELPRRVPMD SSVVYLDGNN FPVLKNHAFI GRKNLRALYV NGSQVAAIQN RTFASLASLQ LLHLADNKLR TLHGYEFEQL SALRELYLQN NQLTTIENAT LAPLAALELI RIDGNRLVTL PIWQMHATHF GTRLKSISLG RNQWSCRCQF LQALTSYVAD NALIVQDAQD IYCIAASSGT GSSALEDSSS NSGSLEKREL DFNATGAACT DYYSGGSMLQ HGIPESYIPL LAAALALLFL LVVIAMVFAF RESLRIWLFA HYGVRVFGPR CEESEKLYDA VLLHSAKDSE FVCQHLAAQL ETGRPPLRVC LQHRDLAHDA THYQLLEATR VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA ESDIELLPYL KTSAVHRIRR SDRHFWEKLR YALPVDYPTF RGNNYTLELD HHNHERVKQP ASPGLLYRQA PPPAYCGPAD AVGIGAVPQV VPVNASVPAE QNYSTATTAT PSPRPQRRGE QPGSGSGGNH HLHAQYYQHH GMRPPSEHIY SSIDSDYSTL DNEQHMLMMP GGPGGLAMEA AQRSQTWRPK REQLHLQQAQ AGTLGSKASQ AAHQQQQQQQ QQQQPNPTAV SGQQQGPHVQ AYLV // ID B4JWD8_DROGR Unreviewed; 1486 AA. AC B4JWD8; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 71. DE SubName: Full=GH23021 {ECO:0000313|EMBL:EDV98276.1}; GN Name=Dgri\GH23021 {ECO:0000313|EMBL:EDV98276.1}; GN ORFNames=Dgri_GH23021 {ECO:0000313|EMBL:EDV98276.1}, GN GH23021 {ECO:0000313|FlyBase:FBgn0130478}; OS Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Hawaiian Drosophila. OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070}; RN [1] {ECO:0000313|EMBL:EDV98276.1, ECO:0000313|Proteomes:UP000001070} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CH916375; EDV98276.1; -; Genomic_DNA. DR RefSeq; XP_001995204.1; XM_001995168.1. DR ProteinModelPortal; B4JWD8; -. DR STRING; 7222.FBpp0156927; -. DR EnsemblMetazoa; FBtr0158435; FBpp0156927; FBgn0130478. DR GeneID; 6569068; -. DR KEGG; dgr:Dgri_GH23021; -. DR FlyBase; FBgn0130478; Dgri\GH23021. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; B4JWD8; -. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B4JWD8; -. DR Proteomes; UP000001070; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001070}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001070}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 1486 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002810059. FT TRANSMEM 1065 1088 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1114 1256 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1486 AA; 165470 MW; B3B1304B66AC0DD1 CRC64; MELRLRLLLA TGLFLILLLN ASWCSASSSS SSDSSSDNSA TNAMLGGSDY SSLLAATQWP VAAASLPPAP AAHSGPTNQC TWTYNGTSAV HCALRLIERQ PGLDLQGADG SSQLTIKCSD LYLFESQLPV AIFARLQTLE TLRVASCKLL QLPNNAFEGL STLKSLALST RNADWAPSKT LELYPDSLNG LKQLTELDLS DNNLRALPAG FLCPVGNLQT LNLTRNRIRT AEQLGFADMN CGSGSSSNGG GGGGSGSELQ LLDASHNELR TITESWGISR LRRLQHLNLQ HNNISELSGE ALAGLASLRI VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD LSGNQLTSNH VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN LRNNSIGHIE DNAFLPLYNL HTLNLAENRL HTLDDKLFNG LYVLSKLTLN NNLISVVEPA VFKNCSDLKE LDLSSNQLNE VPRALQDLAM LRTLDLGENQ IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFADLPRLS VLNLAKNRIQ SIERGAFDKN YELEAIRLDR NFLSDINGVF ATLVSLLWLN LSENHLVWFD YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS IPNTIELLFI NNNLIGNVLA NAFVDKSNLA RVDLYANQLS KLQLQQLRIA PVVAPKPLPE FYLGGNPFEC DCTMDWLQRI NNLTTRQHPR VMDMPNIECV MPHARGATVR PLSALRSQDF LCRYESHCFA LCHCCDFDAC DCEMTCPHNC TCYHDQIWST NVVDCGNQLT MELPRRVPMD SSIVYLDGNN FPVLKNHAFI GRKNLKALYV NGSQVAAIQN RTFASLATLQ VLQLSDNRLQ TLHGYEFEQL SALRELYLHN NQLANIENAT LAPLTSLEVL RLDGNRLVTL PIWQLHATHF GQRLRAISLG RNQWSCRCQF LQALTSYVAE NALIVQDAQD IYCMAAPNAG ATNGYEQSSS GSGTGSSSDQ LATQKRELDF NATGAACTDY YSGGSMLQHG IPESYIPLLA AALALVFLLV VVIMVFVFRE SLRIWLFAHY GVRVFGPRCE ESEKLYDALL LHSAKDSEFV CQHLASELET GRPALRVCLQ HRDLTLGHDA THYQLLEASR VSRRVVILLT RNFLQTEWSR CELRRSLHDA LRGRPQKLVI IEEPEVAFEA ESDIELLPYL KTSAVHRIRR TDRHFWEKLR YALPVDYPTY RGNNYTLDHN HERIKQPASP GLLYRQAPPP AYCGPAEAAA AAAAVAAEQN YSTATTATPS PRPQRRSGGD CATSSAGAGG QHHHQQQQQQ QQHLHAQYYQ HHGGMRPPSE HIYSSIDSDY STLDNEQHML MMPAGANAVA AAAAAPLPPI EAQRAQTWRP QAKQQLQTAH AGTLNPTTAL KVNPQQQQQH QQQQHQQQQH QHQQQASVSS SASGQQQGPH VQAYLV // ID B4KRL5_DROMO Unreviewed; 1445 AA. AC B4KRL5; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 72. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW10441.1}; GN Name=Dmoj\GI21088 {ECO:0000313|EMBL:EDW10441.1}; GN ORFNames=Dmoj_GI21088 {ECO:0000313|EMBL:EDW10441.1}, GN GI21088 {ECO:0000313|FlyBase:FBgn0143820}; OS Drosophila mojavensis (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW10441.1, ECO:0000313|Proteomes:UP000009192}; RN [1] {ECO:0000313|EMBL:EDW10441.1, ECO:0000313|Proteomes:UP000009192} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CH933808; EDW10441.1; -; Genomic_DNA. DR RefSeq; XP_002006506.1; XM_002006470.2. DR ProteinModelPortal; B4KRL5; -. DR EnsemblMetazoa; FBtr0171813; FBpp0170305; FBgn0143820. DR GeneID; 6580703; -. DR KEGG; dmo:Dmoj_GI21088; -. DR FlyBase; FBgn0143820; Dmoj\GI21088. DR InParanoid; B4KRL5; -. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B4KRL5; -. DR Proteomes; UP000009192; Unassembled WGS sequence. DR Bgee; FBgn0143820; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 6. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009192}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000009192}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 1445 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002811314. FT TRANSMEM 1055 1078 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1104 1244 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1445 AA; 160898 MW; ACD4C2968E6FAB6F CRC64; MELRLLLLLS LLLLAGCAGC LGAVPPKPKD ASDKNAASAM LGSSVSLSSD YSSLLAAAQP MAASSPAPVH SGPNNQCTWT YNGTSSVHCS LRLIERQPCL DLQGADGSSQ LTIKCSDLYL FESQLPVAVF ARLQTLDTLR LESCKLLQLP NNAFEGLTTL KALKLSTRNA EWGPAKALEL YPDSLNGLKQ LTELDLSDNN LRALPSGFLC PVGNLQTLNL TRNRIRTAEQ LGFADMNCGA NGGASGASGS GSGSSSGSEL QLLDASYNEL RSITESWGIS RLRRLQHLNL QHNNISELSG EALAGLASLR IVNLSNNHLE TLPEGLFAGS KELREIHLQN NELYELPKGL FHRLEQLLVV DLSGNQLTSN HVDNTTFAGL IRLIVLNLAH NALTRIDYRT FKELYFLQIL NLRNNSIGHI EDNAFLPLYN LHTLNLAENR LHTLDDKLFN GLYVLSKLTL NNNLISVVEP AVFKNCSDLK ELDLSSNQLN EVPRALQDLA MLRTLDLGEN QIRTFDNQSF KNLHQLTGLR LIDNHIGNIT VGMFADLPRL SVLNLAKNRI QSIERGAFDK NYELEAIRLD RNFLSDINGV FATLVSLLWL NLSENHLVWF DYAFIPSNLK WLDIHGNYIE ALGNYYKLQE EIRVKTLDAS HNRITEIGPM SIPNTIELLF INNNLIGNVL PNAFVDKANL ARVDLYANQL SKLQLQQLRI APVLAPKPLP EFYLGGNPFE CDCTMDWLQR INNLTTRQHP RVMDMPNIEC VMPHARGAAV RPLSALRPQD FLCRYESHCF ALCHCCDFDA CDCEMTCPHN CTCYHDQIWS TNVVDCGNQL TMELPRRVPM DSSIVYLDGN NFPVLKNHAF IGRKNLKALY VNGSQVASIQ NRTFASLATL QLLQLSDNRL QTLHGYEFEQ LSALKELYLQ NNQLATIGNG TLAPLVSLEL LRLDGNRLVT LPIWQLHATH FGQRLRAIWL GRNQWSCRCQ FLQALTSYVA DNALIVQDAQ DIYCMAAPNT AAYEQSSSTA AGTQKRELDF NSTGAACTDY YSGGSMLQHG IPESYIPLLA AALALVFLLV VIIIVFVFRE SLRIWLFAHY GVRVFGPRCE ESEKLYDALL LHSAKDSEFV CQHLASELET GRPALRVCLQ HRDLAHDATH YQLLEASRVS RRVVILLTRN FLQTEWSRCE LRRSLHDALR GRPQKLVIIE EPEVAFEAES DIELLPYLKT SAVHRIRRTD RHFWEKLRYA LPVDYPTYRG NNYTLDHNHE RIKQPASPGL LYRQAPPPAY CGPAEAAAAA AAAASVAAAE QNYSTATTAT PSPRPQRRGE RAEAVGVGVG VGVNPGGPHH LHAQYYQHHG MRPPSEHIYS SIDSDYSTLD NEQHMLMMPA ATGAASAEVS QQRAQTWRPQ PKQQQLQTPH AGTLNPSTAV KPNPQQQQQQ ASGQQQGPHV QAYLV // ID B4LPR4_DROVI Unreviewed; 1443 AA. AC B4LPR4; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 74. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW60302.1}; GN Name=Dvir\GJ20935 {ECO:0000313|EMBL:EDW60302.1}; GN ORFNames=Dvir_GJ20935 {ECO:0000313|EMBL:EDW60302.1}, GN GJ20935 {ECO:0000313|FlyBase:FBgn0208071}; OS Drosophila virilis (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW60302.1, ECO:0000313|Proteomes:UP000008792}; RN [1] {ECO:0000313|EMBL:EDW60302.1, ECO:0000313|Proteomes:UP000008792} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CH940648; EDW60302.1; -; Genomic_DNA. DR RefSeq; XP_002049109.1; XM_002049073.2. DR ProteinModelPortal; B4LPR4; -. DR STRING; 7244.FBpp0235352; -. DR EnsemblMetazoa; FBtr0236860; FBpp0235352; FBgn0208071. DR GeneID; 6624912; -. DR KEGG; dvi:Dvir_GJ20935; -. DR FlyBase; FBgn0208071; Dvir\GJ20935. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; B4LPR4; -. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B4LPR4; -. DR Proteomes; UP000008792; Unassembled WGS sequence. DR Bgee; FBgn0208071; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008792}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000008792}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 1443 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002816423. FT TRANSMEM 1048 1071 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1097 1237 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1443 AA; 160911 MW; 20FAD591F6853970 CRC64; MELRLLLLLL LLKGSCLCAL APKDSASSDN SAASHAMLGG GAGAASVSLS NDYSSLLAAA MQPVASSPAP AHSGPSNQCT WTYNGTSSVY CALRLIERQP GLDLQGADGS SQLTIKCSDL YLFESQLPMA VFARLQTLDT LRLESCKLLQ LPNNAFEGLS TLKALKLSTR NAEWGPAKAL ELYPDSLNGL KQLTELDLSD NNLRALPAGF LCPVGNLQTL NLTRNRIRTA EQLGFADMNC GSGGTGSGSE LQLLDASHNE LRSITESWGI SRLRRLQHLN LQHNNISELS GEALAGLASL RIVNLSNNHL ETLPEGLFAG SKELREIHLQ NNELYELPKG LFHRLEQLLV VDLSGNQLTS NHVDNTTFAG LIRLIVLNLA HNALTRIDYR TFKELYFLQI LNLRNNSIGH IEDNAFLPLY NLHTLNLAEN RLHTLDDKLF NGLYVLSKLT LNNNLISVVE PAVFKNCSDL KELDLSSNQL NEVPRALQDL AMLRTLDLGE NQIRTFDNQS FKNLHQLTGL RLIDNQIGNI TVGMFADLPR LSVLNLAKNR IQSIERGAFD KNYELEAIRL DRNFLSDING VFATLVSLLW LNLSENHLVW FDYAFIPSNL KWLDIHGNYI EALGNYYKLQ EEIRVKTLDA SHNRITEIGP MSIPNTIELL FINNNLIGNV LPNAFVDKSN LARVDLYANQ LSKLQLQQLR IAPVLAPKPL PEFYLGGNPF ECDCTMDWLQ RINNLTTRQH PRVMDMPNIE CVMPHARGAA VRPLSALRPQ DFLCRYESHC FALCHCCDFD ACDCEMTCPH NCTCYHDQIW STNVVDCGNQ LTMELPRRVP MDSSIVYLDG NNFPVLKNHA FIGRKNLKAL YVNGSQVAAI QNRTFASLAT LQLLQLSDNR LQTLHGYEFE QLSALRELYL HNNQLANIEN GTLAPLVSLE LLRLDGNRLV TLPIWQLHAT HFGQRLRAIS LGRNQWSCRC QFLQALTSYV AENALIVQDA QDIYCMAAPN TAAAAYADSS SMGAGTQKRE LDFNSTGAAC TDYYSGGSML QHGIPESYIP LLAAALALIF LLVVIIIVFV FRESLRIWLF AHYGVRVFGP RCEESEKLYD ALLLHSAKDS EFVCQHLASE LETGRPALRV CLQHRDLAHD ATHYQLLEAS RVSRRVVILL TRNFLQTEWS RCELRRSLHD ALRGRPQKLV IIEEPEVAFE AESDIELLPY LKTSAVHRIR RTDRHFWEKL RYALPVDYPT YRGNNYTLDH NHERIKQPAS PGLLYRQAPP PAYCGPAEAA AAAVAAATAA VAEQNYSTAT TATPSPRPQR RGEREGVGVA VGVGVNPGGP HHLHAQYYQH HGMRPPSEHI YSSIDSDYST LDNEQHMLMM PAAGAAASLE SQQRAQTWRP QPKQQLQTAH AGTLGPSTAV KSNPQQQQQQ QQQQQQQQAS GQQQGPHVQA YLV // ID B4MRV0_DROWI Unreviewed; 1441 AA. AC B4MRV0; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 74. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW74839.1}; GN Name=Dwil\GK15893 {ECO:0000313|EMBL:EDW74839.1}; GN ORFNames=Dwil_GK15893 {ECO:0000313|EMBL:EDW74839.1}, GN GK15893 {ECO:0000313|FlyBase:FBgn0217896}; OS Drosophila willistoni (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW74839.1, ECO:0000313|Proteomes:UP000007798}; RN [1] {ECO:0000313|EMBL:EDW74839.1, ECO:0000313|Proteomes:UP000007798} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CH963850; EDW74839.1; -; Genomic_DNA. DR RefSeq; XP_002063853.1; XM_002063817.2. DR ProteinModelPortal; B4MRV0; -. DR STRING; 7260.FBpp0245036; -. DR EnsemblMetazoa; FBtr0246544; FBpp0245036; FBgn0217896. DR GeneID; 6640882; -. DR KEGG; dwi:Dwil_GK15893; -. DR FlyBase; FBgn0217896; Dwil\GK15893. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; B4MRV0; -. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B4MRV0; -. DR Proteomes; UP000007798; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007798}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000007798}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 1441 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002818602. FT TRANSMEM 1047 1070 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1096 1236 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1441 AA; 161220 MW; 5C429FD7659E9AFF CRC64; MEQTVLLLLL LPLMVVMMSG SRAALVPKER GNSDNSASAM LGGGAGAATV SLSSDYSSLL SAAVPVASSP APVHSGPNNQ CSWTYNGTSA VHCALRLIER QPGLDLQGAD GSSQLTIKCS DLYMFESTLP VAVFARLQTL ESLRLESCKL LQLPNNAFEG LTTLKSLRLS TRNGEWGPSK ALELYPDSLN GLKQLTELDL SENNLRALPA GFLCPVGNLQ SLNLTRNRIR TAEQLGFADM NCSGGSELQL LDASHNELRS ITESWGISRL RRLQHLNLQH NNISELSGEA LAGLSSLRIV NLSNNHMETL PEGLFAGSKE LREIHLQHNE LYELPKGLFH RLEQLLVVDL SGNQLTSNHV DNTTFAGLIR LIVLNLAHNA LTRIDYRTFK ELYFLQILNL RNNSIGHIED NAFLPLYNLH TLNLAENRLH TLDDKLFNGL YVLSKLTLNN NLISVVEPAV FKNCSDLKEL DLSSNQLNEV PRALQDLAML RTLDLGENQI RTFDNQSFKN LHQLTGLRLI DNQIGNITVG MFADLPRLSV LNLAKNRIQS IERGSFDKNF ELEAIRLDRN FLSDINGVFA TLVSLLWLNL SENHLVWFDY AFIPSNLKWL DIHGNYIEAL GNYYKLQEEI RVKTLDASHN RITEIGPMSI PNTIELLFIN NNLIGNVQPN AFVDKANLAR VDLYANQLSK LQLQQLRVAP VLAPKPLPEF YLGGNPFECD CTMDWLQRIN NLTTRQHPRV MDMPNIECVM PHARGAAVRP LSSLRPQDFL CRYESHCFAL CHCCDFDACD CEMTCPHNCT CYHDQIWSTN VVDCGGQQTM ELPRRVPMDS SIVYLDGNNF PVLKNHAFIG RKNLKALYVN GSQVAGIQNR TFASLASLQL LQLADNRLQV LHGYEFEQLS SLRELYLQNN QLTTIENATL APLVSLEVLR IDGNRLVTLP IWQMHATHFG KRLRSISLGR NQWSCRCQFL QALTSYVSDN AIIVQDAQDI YCMAASNSAN YDVDAYDANG SQGTLQKREL DFNSTGAACT DYYSGGSMLQ HGIPESYIPL LAAALALVFL LVVIIIVFVF RESLRIWLFA HYGVRVFGPR CEESEKLYDA VLLHSAKDSE FVCQHLASEL ETGRPPLRVC LQHRDLAHDA THYQLLEATR VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA ESDIELLPYL KTSAVHRIRR TDRHFWEKLR YALPVDYPTY RGNNYTLDHN HERIKQPASP GLLYRQAPPP AYCGPAEGGP AAAAAAAAAV EQNYSTATTA TPSPRPQRRG DHQGGGGSGS SSHGHHLHAQ YYQHHGMRPP SEHIYSSIDS DYSTLDNEQH MLMMPNGPPS MEGQRAQTWR PKQQQQQQQP PNAMGHAGTL GPSSNLAKAT SQQQQQQQQQ QQQQPTGSGQ QQGPHVQAYL V // ID B4MWH6_DROWI Unreviewed; 649 AA. AC B4MWH6; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-FEB-2018, entry version 63. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW76117.1}; GN Name=Dwil\GK15289 {ECO:0000313|EMBL:EDW76117.1}; GN ORFNames=Dwil_GK15289 {ECO:0000313|EMBL:EDW76117.1}, GN GK15289 {ECO:0000313|FlyBase:FBgn0217294}; OS Drosophila willistoni (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7260 {ECO:0000313|EMBL:EDW76117.1, ECO:0000313|Proteomes:UP000007798}; RN [1] {ECO:0000313|EMBL:EDW76117.1, ECO:0000313|Proteomes:UP000007798} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 14030-0811.24 {ECO:0000313|Proteomes:UP000007798}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CH963857; EDW76117.1; -; Genomic_DNA. DR RefSeq; XP_002065131.1; XM_002065095.1. DR ProteinModelPortal; B4MWH6; -. DR STRING; 7260.FBpp0244432; -. DR EnsemblMetazoa; FBtr0245940; FBpp0244432; FBgn0217294. DR GeneID; 6642539; -. DR KEGG; dwi:Dwil_GK15289; -. DR FlyBase; FBgn0217294; Dwil\GK15289. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; B4MWH6; -. DR OMA; EHNDEEL; -. DR OrthoDB; EOG091G00ZN; -. DR PhylomeDB; B4MWH6; -. DR Proteomes; UP000007798; Unassembled WGS sequence. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00013; LRRNT; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 6. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007798}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000007798}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 496 634 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 649 AA; 76105 MW; 8444197E5EB60568 CRC64; MGETYLYFES NDLTQLPNTS TQDYNNLRRL HLANNNLTNI QINQLPKNLE YLDIRNNNIT SLDPNVASFL LERKDNISVE QSGIYWKCNC NNTSLLNYLK LKEKEEDYDD YMYHEINSRV NFHHIKGPCP ESCTCCVNGY EDQFIINCTS KALETFPTLP NKILGEPSLL LDNNLIETLS TSSLRNSTLR ELHLKHNSLT HIHLDQLPSN LRVLDIRQNN FTGLDDDVTQ FISKLSKVQL SENPWQCSCK FIQFLAHLKK VNFTEYQAAL RRCSGQEYCP ELCICCKEDE SQRFIINCSN LGLPEMPAEL PITENATLLF ENNNLQTLDN STKIIGLNQL KELHLRYNNL TKIEVLPKNI QFLDIRNNSL TILNESVREF LTQKSNMSSL TIFISGNNWI CHCKEIRFFR FTKNLAENIK DLCKTECHDS RLFVSLEEID LCPEKIPRYV IYFTSFIMLS CLLSFLQCFW KSIVMWLYEK RLFLKLTTRL EKGTETKYDC FLAYCHKDSH LVSEYVERLE HGRNRLRLCF YERDWLAGEP IPDCICHSVE NSKCIVILMT KNFLKSVWGR LEFRLALHAT SKDLYKRLIV IIYPGVENFD ELDGELNSYL KLNTYLIRND TNFWNKLIYT LPHKIINEDE DIEMINIEH // ID B4QEI1_DROSI Unreviewed; 1444 AA. AC B4QEI1; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 68. DE SubName: Full=GD11482 {ECO:0000313|EMBL:EDX07855.1}; GN Name=Dsim\GD11482 {ECO:0000313|EMBL:EDX07855.1}; GN ORFNames=Dsim_GD11482 {ECO:0000313|EMBL:EDX07855.1}, GN Dsimw501_GD11482 {ECO:0000313|EMBL:KMY95189.1}, GN GD11482 {ECO:0000313|FlyBase:FBgn0084945}; OS Drosophila simulans (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX07855.1, ECO:0000313|Proteomes:UP000000304}; RN [1] {ECO:0000313|EMBL:EDX07855.1, ECO:0000313|Proteomes:UP000000304} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Mixed {ECO:0000313|EMBL:EDX07855.1}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). RN [2] {ECO:0000313|EMBL:EDX07855.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDX07855.1}; RG FlyBase; RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:KMY95189.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=W501 {ECO:0000313|EMBL:KMY95189.1}; RX PubMed=22936249; DOI=10.1101/gr.141689.112; RA Hu T.T., Eisen M.B., Thornton K.R., Andolfatto P.; RT "A second-generation assembly of the Drosophila simulans genome RT provides new insights into patterns of lineage-specific divergence."; RL Genome Res. 23:89-98(2013). RN [4] {ECO:0000313|EMBL:KMY95189.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=W501 {ECO:0000313|EMBL:KMY95189.1}; RA Hu T., Eisen M.B., Thornton K.R., Andolfatto P.; RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:KMY95189.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=W501 {ECO:0000313|EMBL:KMY95189.1}; RG FlyBase; RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM000362; EDX07855.1; -; Genomic_DNA. DR EMBL; CM002911; KMY95189.1; -; Genomic_DNA. DR RefSeq; XP_002082270.1; XM_002082234.2. DR EnsemblMetazoa; FBtr0211392; FBpp0209884; FBgn0084945. DR GeneID; 6735319; -. DR KEGG; dsi:Dsimw501_GD11482; -. DR FlyBase; FBgn0084945; Dsim\GD11482. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B4QEI1; -. DR Proteomes; UP000000304; Chromosome 2R. DR Bgee; FBgn0084945; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 6. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 20. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 23. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000304}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000000304}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 1444 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007642020. FT TRANSMEM 1047 1070 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1096 1236 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1444 AA; 160778 MW; D2C88C4D1D1424E8 CRC64; MAAILLLLLG FSWSLAVESA LAPKESESSA SAMLGAGTGA AATVSLSGDY SSLLSNVPAA SPVPANPSQH SGPANQCSWS YNGTSSVHCA LRLIERQPGL DLQGADGSSQ LTIQCSELYL FESTLPVAVF ARLQTLEALR LESCKLLQFP NNAFEGLATL KSLRLSTHNS EWGPTRTLEL FPDSLGGLKQ LTDLDLGDNN LRQLPSGFLC PVGNLQVLNL TRNRIRTAEQ LGFADMNCGA GSGSAGSELQ ILDASHNELR SISESWGISR LRRLQHLNLA YNNISELSGE ALAGLASLRI VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD LSGNQLTSNH VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN LRNNSIGHIE DNAFLPLYNL HTLNLAENRL HTLDDKLFNG LYVLSKLTLN NNLISVVEPA VFKNCSDLKE LDLSSNQLNE VPRALQDLAM LRTLDLGENQ IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFQDLPRLS VLNLAKNRIQ SIERGSFDKN FELEAIRLDR NFLADINGVF ATLVSLLWLN LSENHLVWFD YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS IPNTIELLFI NNNLIGNVQP NAFVDKANLA RVDLYANQLS KLQLQQLRVA PVVAPKPLPE FYLGGNPFEC DCTMDWLQRI NNLTTRQHPR VMDMANIECV MPHARGAAVR PLSGLRPQDF LCRYESHCFA LCHCCDFDAC DCEMTCPSNC TCYHDQIWST NVVDCGGQQT TELPRRVPMD SSVVYLDGNN FPVLKNHAFI GRKNLRALYV NGSQVAAIQN RTFASLASLQ LLHLADNKLR TLHGYEFEQL SALRELYLQN NQLTTIENAT LAPLAALELI RIDGNRLVTL PIWQMHATHF GTRLKSISLG RNQWSCRCQF LQALTSYVAD NALIVQDAQD IYCMAASSGT GSAALEDSSS NSGSLEKREL DFNATGAACT DYYSGGSMLQ HGIPESYIPL LAAALALLFL LVVIAMVFAF RESLRIWLFA HYGVRVFGPR CEESEKLYDA VLLHSAKDSE FVCQHLAAQL ETGRPPLRVC LQHRDLAHDA THYQLLEATR VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA ESDIELLPYL KTSAVHRIRR SDRHFWEKLR YALPVDYPTF RGNNYTLELD HHNHERVKQP ASPGLLYRQA PPPAYCGPAD AVGIGAVPQV VPVNASVPAE QNYSTATTAT PSPRPQRRGE QPGSGSGGNH HLHAQYYQHH GMRPPSEHIY SSIDSDYSTL DNEQHMLMMP GAPGGLAMEA AQRAQTWRPK REQLHLQQAQ AGTLGSKASQ AAHQQQQQQQ QQQQPNPTAV SGQQQGPHVQ AYLV // ID B4QWS2_DROSI Unreviewed; 1096 AA. AC B4QWS2; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 28-MAR-2018, entry version 65. DE SubName: Full=Toll {ECO:0000313|EMBL:EDX14589.1}; GN Name=Tl {ECO:0000313|FlyBase:FBgn0028769}; GN Synonyms=Dsim\Tl {ECO:0000313|EMBL:EDX14589.1}; GN ORFNames=Dsim_GD21307 {ECO:0000313|EMBL:EDX14589.1}, GN GD21307 {ECO:0000313|FlyBase:FBgn0028769}; OS Drosophila simulans (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7240 {ECO:0000313|EMBL:EDX14589.1, ECO:0000313|Proteomes:UP000000304}; RN [1] {ECO:0000313|EMBL:EDX14589.1, ECO:0000313|Proteomes:UP000000304} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Mixed {ECO:0000313|EMBL:EDX14589.1}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM000364; EDX14589.1; -; Genomic_DNA. DR EnsemblMetazoa; FBtr0221217; FBpp0219709; FBgn0028769. DR FlyBase; FBgn0028769; Dsim\Tl. DR OMA; PAIMIAN; -. DR OrthoDB; EOG091G00ZN; -. DR PhylomeDB; B4QWS2; -. DR ChiTaRS; Tl; fly. DR Proteomes; UP000000304; Chromosome 3R. DR Bgee; FBgn0028769; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01462; LRRNT; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000304}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000000304}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 1096 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002821248. FT TRANSMEM 804 827 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 856 995 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1096 AA; 124638 MW; 36DFD1B1530FA122 CRC64; MSRLKAASEL ALLVMILQLL QWPGSEASFG RDACSEMSID GLCQCAPIMS EYEIICPANA ENPTFRLTIQ PNDYVQIMCN LTDTSDYKQL PKKLRIGEVD RVQMRRCMLP GYTPIASILD YLGIVSPTTL IFESDNLGMN ITRQHLDRLH GLKRFRFTTR RLTHIPANLL TDMRNLSHLE LRANIEEMPS HLFDDLENLE SIEFGSNKLR QMPRGIFGKM PKLKQLNLWS NQLHNLTKHD FEGATSVLGI DIHDNGIEQL PHDVFAHLTN VTDINLSANL FRSLPQGLFD HNKHLNEVRL MNNRVPLATL PSRLFANQPE LKILRLRADL QSLPGDLFEH STQITNISLG DNLLSTLPAT LLEHQVNLLS LDLSNNRLTH LPDSLFAYTT NLTDLRLEDN LLTGISGDIF SNLGNLETLV MSRNRLRTID SRAFISTYGL RHLHLDHNDI DLQQPLLDIM LQTQINSPFG YMHGLLTLNL RNNSIIFVYN DWKNTMLQLR ELDLSYNNIS SLGYEDLAFL SQNRLHVNMT HNKIRRIALT KDVHLGEDYT NLVHVDLNDN PLVCDCTILW FIQLVRGVHK PQYSRQFKLR TDRLVCSQPN ALEGTPVRQV EPQTLICPLD FSDDPRERKC PRGCNCHVRT YDNALVINCH SGNLTHVPRL PNLHQNMRLM ELHLENNTLL RLPSANTPGY ESVTSLHLAG NNLTSIDVDQ LPTNLTHLDV SWNHLQMLNA TVLGFLNRTM KWRSVKLSGN PWMCDCTAKP LLLFTQDNFE RIGDRNEMMC VDAEVPTRMV ELSTNDICPA EKGVFIALAV VIALTGLLAG FTAALYYKYQ TEIKIWLYAH NRLLWLITEE DVDKDKKFDA FISYSHKDQS FIEDYLVPQL EHGPQKFQLC VHERDWLVGG HIPENIMRSV ADSRRTIIVL SQNFIKSEWA RLEFRAAHRS ALNEGRSRII VIIYSDIGDV EKLDEELKAY LKMNTYLKWG DPWFWDKLRY ALPHRRPVGN IGNGALIKTA LKGSTDDKLE LIKPSPVTPP LTTPPAEATK NPLVAQLNGV TPHQAIMIAN GKNGLTNLYT PNGKSHGNGH INGAFIINTN AKQSDV // ID B7QAF7_IXOSC Unreviewed; 1344 AA. AC B7QAF7; DT 10-FEB-2009, integrated into UniProtKB/TrEMBL. DT 10-FEB-2009, sequence version 1. DT 28-MAR-2018, entry version 72. DE SubName: Full=Toll, putative {ECO:0000313|EMBL:EEC15829.1, ECO:0000313|VectorBase:ISCW022740-PA}; DE EC=3.1.3.16 {ECO:0000313|EMBL:EEC15829.1}; GN Name=8038298 {ECO:0000313|VectorBase:ISCW022740-PA}; GN ORFNames=IscW_ISCW022740 {ECO:0000313|EMBL:EEC15829.1}; OS Ixodes scapularis (Black-legged tick) (Deer tick). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; OC Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes. OX NCBI_TaxID=6945 {ECO:0000313|Proteomes:UP000001555}; RN [1] {ECO:0000313|EMBL:EEC15829.1, ECO:0000313|Proteomes:UP000001555, ECO:0000313|VectorBase:ISCW022740-PA} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555, RC ECO:0000313|VectorBase:ISCW022740-PA}, and RC Wikel colony {ECO:0000313|EMBL:EEC15829.1}; RG Ixodes scapularis Genome Project Consortium; RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., RA Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J., RA Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G., RA Meyer J., Hill C.A., Birren B., Nene V., Collins F., RA Alarcon-Chaidez F., Wikel S., Strausberg R.; RT "Annotation of Ixodes scapularis."; RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|VectorBase:ISCW022740-PA} RP IDENTIFICATION. RC STRAIN=wikel {ECO:0000313|VectorBase:ISCW022740-PA}; RG VectorBase; RL Submitted (FEB-2017) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABJB010834466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABJB010959653; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DS894332; EEC15829.1; -; Genomic_DNA. DR RefSeq; XP_002400628.1; XM_002400584.1. DR UniGene; Isc.6147; -. DR ProteinModelPortal; B7QAF7; -. DR STRING; 6945.ISCW022740-PA; -. DR PRIDE; B7QAF7; -. DR EnsemblMetazoa; ISCW022740-RA; ISCW022740-PA; ISCW022740. DR GeneID; 8038298; -. DR KEGG; isc:IscW_ISCW022740; -. DR VectorBase; ISCW022740-RA; ISCW022740-PA; ISCW022740. DR CTD; 8038298; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; B7QAF7; -. DR OMA; WSTMSLE; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; B7QAF7; -. DR Proteomes; UP000001555; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 7. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 25. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001555}; KW Hydrolase {ECO:0000313|EMBL:EEC15829.1}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001555}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 1134 1158 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1184 1323 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1344 AA; 152198 MW; A78B9532801793BA CRC64; MWAADFGCPA RERPSPPKSV TEGPHRQRAR RSGPTPAARG EPAVHLRGVP EAEHQPPASP RRPKVSRARR TPGREPARSA SVEPIRAPAA AVSEQFSEDY RRCRTSLRPL LQKSDAFDPP RSTSEAVGAP RDAVVFRLVV VVVTEPSSSS AAGMRRRWCR ALPLLLLLVW WFPVHPSEAA RYVAPEDCRW EPLDATGVAL SCAVRTLSGG PEPSNFSLIQ PGHTARLTVR CDDLLFESDL INGSFGHLSG LRSLTIERCK IETVPPLAFA GLSELRNLSI RTYNTDWGKF SLRLSPDSLS PLRQLVRLDL SRNNMDSLPP SVLCPLVQLV QVNLTRNRFV EVARMGFSET RCSPLVQKLD AAHNRLRVLS EKGFASLRQL RELKLDHNQI ARAEQGALVG LSRLQNLDMA HNALVALPPR FLQATEKLSE LYLRNNSLSA LPPGLFSGLD QLTTLDLAHN QLSSGWLGPD TLADLTRLTV LDLSHNRLTR LDESSFRSLH SLQTLQLQHN LIESIADLAF ASLYNLHTLV LSHNRLKSVG MHMFSGLSSV GGLYLDHNRL ESLHSDAFHN MSTLQEIILA GNRLSSVPKV VQSLQFLRSL DVADNIITDI QNASYQGLRH LYGLNLMGNH IGNLSQGAFH DLPSLRILNL ARNGIQSIEQ GTFDDVPDLH ALRLDSNFLD DVNGLFSNLH DLIMLNISAN RVRWFDYALI PIGLQWLDIH DNQIEALGNY FELESILKLR TLDVSHNRLT DLDSSSLPNG IEIVFLRNNQ LRRIQPFTFL GKQNLTRVDL TENRLETLDM TMFRLSEVPS TRPLPQFMVA GNPYLCDCHM EWLQRLGNLD DSRQYPRVID LADVVCHLSF TRRKATLPLV KAHSSQFLCR YRNHCFALCH CCDFDACDCE MVCPDNCTCY YDQSWNTNIV DCSARAHIAV PKQLPMDVTE LYLDGNDIPA LSSHTFIGRK NMKVLYLNSS NVQTVHNRTF SGLRTLRVLR LERNRLATLH GYEFDGLGEL KELYLSYNHL THVNNATFVP LKSLEVLHLD HNYILEMAIW NLQLQPRLND VRLADNPWSC DCHFAQEFTD FLQNKGAELV RDLFSIQCVH NETSALPLWE LNTTSCTNVS EATTLVRHFQ VEDLVPLLVV LAALFLLLVC IVVLAFVYRR HLSVWFYTKY GVRMFQRAPA EEEKLFDAFV SYSKKDEAFV AQILAPELEC GQPPYRLCLH YRDLPMAGGY LTDAITEAVE SSRRTIVILS EHFLKSEWCR YEFKSAHHEV LHSCTHRLVV IFLGRVSYKE LDPDIRLWLK SSTFLRWGEK RFWDKLRYAM PDTRHRKPGV PGSRSDVASV AVHI // ID C4PCM1_CHICK Unreviewed; 1059 AA. AC C4PCM1; DT 07-JUL-2009, integrated into UniProtKB/TrEMBL. DT 07-JUL-2009, sequence version 1. DT 28-MAR-2018, entry version 82. DE SubName: Full=TLR7 {ECO:0000313|EMBL:ACR26208.1}; DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:APJ35953.1, ECO:0000313|Ensembl:ENSGALP00000026726}; GN Name=TLR7 {ECO:0000313|EMBL:APJ35953.1, GN ECO:0000313|Ensembl:ENSGALP00000026726}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ACR26208.1}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000026726, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000026726, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|EMBL:ACR26208.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=114 {ECO:0000313|EMBL:ACR26250.1}, RC 19 {ECO:0000313|EMBL:ACR26244.1}, 190 {ECO:0000313|EMBL:ACR26208.1}, RC 209 {ECO:0000313|EMBL:ACR26210.1}, 228 {ECO:0000313|EMBL:ACR26212.1}, RC 247 {ECO:0000313|EMBL:ACR26214.1}, 266 {ECO:0000313|EMBL:ACR26216.1}, RC 285 {ECO:0000313|EMBL:ACR26218.1}, 304 {ECO:0000313|EMBL:ACR26220.1}, RC 323 {ECO:0000313|EMBL:ACR26232.1}, 342 {ECO:0000313|EMBL:ACR26234.1}, RC 361 {ECO:0000313|EMBL:ACR26222.1}, 38 {ECO:0000313|EMBL:ACR26246.1}, RC 380 {ECO:0000313|EMBL:ACR26224.1}, 399 {ECO:0000313|EMBL:ACR26236.1}, RC 418 {ECO:0000313|EMBL:ACR26238.1}, 437 {ECO:0000313|EMBL:ACR26240.1}, RC 456 {ECO:0000313|EMBL:ACR26242.1}, 457 {ECO:0000313|EMBL:ACR26243.1}, RC 475 {ECO:0000313|EMBL:ACR26245.1}, 494 {ECO:0000313|EMBL:ACR26247.1}, RC 513 {ECO:0000313|EMBL:ACR26248.1}, 57 {ECO:0000313|EMBL:ACR26249.1}, RC 570 {ECO:0000313|EMBL:ACR26251.1}, 646 {ECO:0000313|EMBL:ACR26209.1}, RC 665 {ECO:0000313|EMBL:ACR26211.1}, 684 {ECO:0000313|EMBL:ACR26213.1}, RC 703 {ECO:0000313|EMBL:ACR26215.1}, 722 {ECO:0000313|EMBL:ACR26217.1}, RC 741 {ECO:0000313|EMBL:ACR26219.1}, 760 {ECO:0000313|EMBL:ACR26221.1}, RC 779 {ECO:0000313|EMBL:ACR26233.1}, 798 {ECO:0000313|EMBL:ACR26235.1}, RC 817 {ECO:0000313|EMBL:ACR26223.1}, 836 {ECO:0000313|EMBL:ACR26225.1}, RC 855 {ECO:0000313|EMBL:ACR26237.1}, 874 {ECO:0000313|EMBL:ACR26239.1}, RC and 893 {ECO:0000313|EMBL:ACR26241.1}; RX PubMed=20483729; DOI=10.4049/jimmunol.0903092; RA Downing T., Lloyd A.T., O'Farrelly C., Bradley D.G.; RT "The differential evolutionary dynamics of avian cytokine and TLR gene RT classes."; RL J. Immunol. 184:6993-7000(2010). RN [3] {ECO:0000313|Ensembl:ENSGALP00000026726} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000026726}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000313|EMBL:APJ35953.1} RP NUCLEOTIDE SEQUENCE. RA Bainova Z., Buchtova L., Smidova A., Bryjova A., Pojezdna A., RA Munclinger P., Vinkler M.; RT "Genetic diversity of innate immune receptors in artificially selected RT ancient chicken breeds."; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AADN04000416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FJ915557; ACR26208.1; -; Genomic_DNA. DR EMBL; FJ915558; ACR26209.1; -; Genomic_DNA. DR EMBL; FJ915559; ACR26210.1; -; Genomic_DNA. DR EMBL; FJ915560; ACR26211.1; -; Genomic_DNA. DR EMBL; FJ915561; ACR26212.1; -; Genomic_DNA. DR EMBL; FJ915562; ACR26213.1; -; Genomic_DNA. DR EMBL; FJ915563; ACR26214.1; -; Genomic_DNA. DR EMBL; FJ915564; ACR26215.1; -; Genomic_DNA. DR EMBL; FJ915565; ACR26216.1; -; Genomic_DNA. DR EMBL; FJ915566; ACR26217.1; -; Genomic_DNA. DR EMBL; FJ915567; ACR26218.1; -; Genomic_DNA. DR EMBL; FJ915568; ACR26219.1; -; Genomic_DNA. DR EMBL; FJ915569; ACR26220.1; -; Genomic_DNA. DR EMBL; FJ915570; ACR26221.1; -; Genomic_DNA. DR EMBL; FJ915571; ACR26222.1; -; Genomic_DNA. DR EMBL; FJ915572; ACR26223.1; -; Genomic_DNA. DR EMBL; FJ915573; ACR26224.1; -; Genomic_DNA. DR EMBL; FJ915574; ACR26225.1; -; Genomic_DNA. DR EMBL; FJ915581; ACR26232.1; -; Genomic_DNA. DR EMBL; FJ915582; ACR26233.1; -; Genomic_DNA. DR EMBL; FJ915583; ACR26234.1; -; Genomic_DNA. DR EMBL; FJ915584; ACR26235.1; -; Genomic_DNA. DR EMBL; FJ915585; ACR26236.1; -; Genomic_DNA. DR EMBL; FJ915586; ACR26237.1; -; Genomic_DNA. DR EMBL; FJ915587; ACR26238.1; -; Genomic_DNA. DR EMBL; FJ915588; ACR26239.1; -; Genomic_DNA. DR EMBL; FJ915589; ACR26240.1; -; Genomic_DNA. DR EMBL; FJ915590; ACR26241.1; -; Genomic_DNA. DR EMBL; FJ915591; ACR26242.1; -; Genomic_DNA. DR EMBL; FJ915592; ACR26243.1; -; Genomic_DNA. DR EMBL; FJ915593; ACR26244.1; -; Genomic_DNA. DR EMBL; FJ915594; ACR26245.1; -; Genomic_DNA. DR EMBL; FJ915595; ACR26246.1; -; Genomic_DNA. DR EMBL; FJ915596; ACR26247.1; -; Genomic_DNA. DR EMBL; FJ915597; ACR26248.1; -; Genomic_DNA. DR EMBL; FJ915598; ACR26249.1; -; Genomic_DNA. DR EMBL; FJ915599; ACR26250.1; -; Genomic_DNA. DR EMBL; FJ915600; ACR26251.1; -; Genomic_DNA. DR EMBL; KU235437; APJ35953.1; -; Genomic_DNA. DR EMBL; KU235438; APJ35954.1; -; Genomic_DNA. DR EMBL; KU235439; APJ35955.1; -; Genomic_DNA. DR EMBL; KU235440; APJ35956.1; -; Genomic_DNA. DR EMBL; KU235441; APJ35957.1; -; Genomic_DNA. DR EMBL; KU235442; APJ35958.1; -; Genomic_DNA. DR EMBL; KU235443; APJ35959.1; -; Genomic_DNA. DR EMBL; KU235444; APJ35960.1; -; Genomic_DNA. DR EMBL; KU235445; APJ35961.1; -; Genomic_DNA. DR EMBL; KU235446; APJ35962.1; -; Genomic_DNA. DR EMBL; KU235447; APJ35963.1; -; Genomic_DNA. DR EMBL; KU235448; APJ35964.1; -; Genomic_DNA. DR UniGene; Gga.22176; -. DR STRING; 9031.ENSGALP00000026726; -. DR Ensembl; ENSGALT00000026777; ENSGALP00000026726; ENSGALG00000016590. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000230468; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Reactome; R-GGA-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-GGA-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-GGA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-GGA-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-GGA-975155; MyD88 dependent cascade initiated on endosome. DR Proteomes; UP000000539; Chromosome 1. DR Bgee; ENSGALG00000016590; -. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:APJ35953.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 21 40 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 850 874 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 899 1046 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1059 AA; 122265 MW; 98312C6FB0527192 CRC64; MTNLSEVAAH RKMVHHARTS NALLFVLLFL FPMLLSGRWF PKTLPCDVEA FESTVRVDCS DRRLKEVPRG IPGNATNLTL TINHIPRISP ASFTQLENLV EIDFRCNCVP PRLGPKDNVC VTPPSIENGS FAALTRLKSL YLDANQLSKI PRGLPATLRL LSLEANNIFS IKKNTFSELR NIELLYLGQN CYYRNPCNVS FEIEETAFLN LKNLTVLSLK SNNLTFIPPN LSSTLKELYI YNNRIQEVQE HDLSNLYNLE ILDLSGNCPR CYNAPYPCTP CPNISIKIHS KAFYSLKKLR ILRLHSNSLQ SIPSSWFKNI KNLKNLDLSQ NFLIKEIGDA EFLKLIPSLV ELDLSFNFEL QMYSPFLNLS KTFSCLSNLE TLRIKGYVFK ELREENLDPL LNLRNLTVLD LGTNFIKIAD LRVFKKFRSL KIIDLSMNKI SPSSGEGNFY GFCSDHRITV EQYSRHVLQE MHYFRYDEYG RSCKSKDKEA DSYQPLVNGD CMSYGETLDL SRNNIFFVNS IDFQDLSFLK CLNLSGNAIS QTLNGSEFYY LSGLKYLDFS NNRIDLLYST AFKELKFLEI LDLSNNKHYF LAEGVSHVLS FMKNLAYLKK LMMNENEIST SISTGMESQS LQTLEFRGNR LDIFWSDGKK EYLSFFKNLT NLEQLDISSN MLNFLPPDVF EAMPPELKIL NLTSNRLHTF NWGKLHLLTK LITLDLSNNL LTTVPRKLSN CTSTLQELIL RNNRITRITK YFLRGAIQLT YLDLSSNKIQ IIKKSSFPEN IINNLRMLLL HNNPFKCNCD AVWFVGWINQ TQVAIPLLAT DVTCAGPGAH KGRSLVFLDL NTCELDTSYF IMYALSTSAV LCLMMFAVMS HLYFWDVWYS YHYCTAKLKG YRRIPLPDAC YDAFIAYDNT DLAVNEWVMT ELVEKLEDQK ARQFNLCLEE RDWLPGQPVF DNLSQSIQLS KKTIFVLTNK YIKSGTFKTT FYMAHQRLLD EKIDVIILIF LEKVLQKSRY VQLRKRLCRS SVLEWPTNPR SQPYFWQRLK NAIAMNNTLS YNKLLQETV // ID D2HJD6_AILME Unreviewed; 858 AA. AC D2HJD6; DT 09-FEB-2010, integrated into UniProtKB/TrEMBL. DT 09-FEB-2010, sequence version 1. DT 28-MAR-2018, entry version 71. DE SubName: Full=Toll like receptor 5 {ECO:0000313|Ensembl:ENSAMEP00000021245}; DE Flags: Fragment; GN Name=TLR5 {ECO:0000313|Ensembl:ENSAMEP00000021245}; GN ORFNames=PANDA_011408 {ECO:0000313|EMBL:EFB14142.1}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB14142.1}; RN [1] {ECO:0000313|EMBL:EFB14142.1, ECO:0000313|Ensembl:ENSAMEP00000021245} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000021245} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ACTA01130611; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GL192912; EFB14142.1; -; Genomic_DNA. DR RefSeq; XP_002922437.1; XM_002922391.3. DR RefSeq; XP_011227212.1; XM_011228910.2. DR RefSeq; XP_011227213.1; XM_011228911.2. DR STRING; 9646.ENSAMEP00000021245; -. DR Ensembl; ENSAMET00000022014; ENSAMEP00000021245; ENSAMEG00000020191. DR GeneID; 100475654; -. DR KEGG; aml:100475654; -. DR CTD; 7100; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000008675; -. DR KO; K10168; -. DR OMA; KYDAYLC; -. DR OrthoDB; EOG091G030N; -. DR TreeFam; TF351113; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027176; TLR5. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44698:SF2; PTHR44698:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 858 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014087317. FT DOMAIN 691 827 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 858 858 {ECO:0000313|EMBL:EFB14142.1}. SQ SEQUENCE 858 AA; 96942 MW; F8B5CF1400F7FB10 CRC64; MGGHLDLLFG VMLAASPVLA IPSCASDGQR ALYRSCNLTQ VPPVPSTTQV LLLSFNYIRT VTTTSFPFLE QLQLLELGTQ FTPFTIGREA FRNLPNLRVL DLGNSQVDFL HPDAFQGLPH LLELRLLYCG LSDTVLQDGY FRNLGSLSRL DLSKNEIRSL KLHPSFWELN SLKSIDFSLN QIPIVCEHEL QPLQGKTLSL FNLAANHLYS RVSVDWGACM NPFTDMVLET LDVSGNGWTA DITGNFSRAI SGSRISSLVL AHHIMGPGFG FQNIRDPDRD TFAGLAGSAV LRLDLSHGFI FSLNFRLFEA LKALKLLNLA HNKINRIAGE AFYGLDSLQV LNMSYNLLGE LYNSDFYGLP QVAYIDLQNN HIGIIQDRTF RFLKTLHTLD LRDNALKTIS FLPSINTIFL SSNKLVTLQN MRLKANFLHL SENRLEDLDD LYFLLRVPDL QVLILNQNRF SSCSRAHGPT GSRSLEKLFL GGNMLQLAWE TGFCWDVFKG LSRLQILYLN NNYLTFLPPG ALSDLTALRG LDLNSNRLTA LAPGDLPANL EVLDVSRNQL LSLDPDLFAS LRAVDITHNR FICECDLRPL ITWLNQTNVT VFGSHADIYC MYPNELAGTP LSSVSMEDCD EEEVLKVIKL SLFISSTVTL TLFLVTIVVV TKLRGLCFIC YRAAHRLLPT VYAERRESDT YKYDAYLCFS GRDFEWVQRA LLRHLDAQYS DQNRFNLCFE ERDFVPGREH IANIQDAVWG SRKVVCLVSR HFLRDGWCLE AFTYAQNRCV SDLDGALILV IVGSLSQYDL RKHQCIRGFV RKRQYLRWPE DLQDVGWFLH TLSQHILKKG KDAKRDGSIP LQTVAAVS // ID D6WCJ1_TRICA Unreviewed; 1310 AA. AC D6WCJ1; DT 10-AUG-2010, integrated into UniProtKB/TrEMBL. DT 10-AUG-2010, sequence version 1. DT 28-FEB-2018, entry version 52. DE SubName: Full=Toll-7-like protein {ECO:0000313|EMBL:EEZ99327.1}; GN ORFNames=TcasGA2_TC004474 {ECO:0000313|EMBL:EEZ99327.1}; OS Tribolium castaneum (Red flour beetle). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; OC Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium. OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EEZ99327.1, ECO:0000313|Proteomes:UP000007266}; RN [1] {ECO:0000313|EMBL:EEZ99327.1, ECO:0000313|Proteomes:UP000007266} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ99327.1, RC ECO:0000313|Proteomes:UP000007266}; RX PubMed=18362917; DOI=10.1038/nature06784; RG Tribolium Genome Sequencing Consortium; RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., RA Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., RA Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D., RA Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., RA Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., RA Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., RA Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., RA Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., RA Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., RA Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., RA Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., RA Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., RA Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., RA Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., RA Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., RA Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., RA Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., RA Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., RA Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., RA Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., RA Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., RA Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., RA Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., RA Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., RA Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., RA Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., RA Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., RA Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., RA Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., RA Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., RA Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., RA Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., RA Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., RA Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., RA Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., RA Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., RA Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.; RT "The genome of the model beetle and pest Tribolium castaneum."; RL Nature 452:949-955(2008). RN [2] {ECO:0000313|EMBL:EEZ99327.1, ECO:0000313|Proteomes:UP000007266} RP GENOME REANNOTATION. RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ99327.1, RC ECO:0000313|Proteomes:UP000007266}; RX PubMed=19820115; DOI=10.1093/nar/gkp807; RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.; RT "BeetleBase in 2010: revisions to provide comprehensive genomic RT information for Tribolium castaneum."; RL Nucleic Acids Res. 38:D437-D442(2010). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KQ971311; EEZ99327.1; -; Genomic_DNA. DR RefSeq; XP_972409.1; XM_967316.3. DR ProteinModelPortal; D6WCJ1; -. DR STRING; 7070.TC004474-PA; -. DR EnsemblMetazoa; TC004474_001; TC004474_001; TC004474. DR GeneID; 661135; -. DR KEGG; tca:661135; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; D6WCJ1; -. DR OMA; NHAFIGR; -. DR PhylomeDB; D6WCJ1; -. DR Proteomes; UP000007266; Linkage group 2. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 6. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 20. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007266}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00138699}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007266}; KW Repeat {ECO:0000256|SAAS:SAAS00490532}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 1310 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003089526. FT TRANSMEM 979 1003 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1035 1173 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1310 AA; 148395 MW; 382F6E824DEC8DCC CRC64; MWLELVLNLV FLATCLSATR YDGPEGCSWL PDNNDTSSSK FSVTCRVRTL DGTGTNISAL PAEITSKLRL LCSEVLFFES ALPTQGLQRL HELEELQITN CKLLNIEANS FEGLYNVKRL AINTFNSDWS SSKTLDINAD SLKGLKELQI LDLANNNIRA VVDGTFCSLA NLQTLNLTRN RIKSPERFGF NLPECSNSEL QNLDLSHNEL RALTENSGFS RLRRLQQLDL KNNNISDISG EALAGLVSLR ILNLANNKIE SLPEGLFAGS RELREIHLQN NSLFSLAKGL FHRLEQLLIL DLSGNQLTSN HVDAGTFAGL IRLIVLNLSH NALTRIDSKT FKDLYFLQIL DLRNNSIGFI EDNAFIPLYN LHTLNLAENR LNTIGPLLFN GLFVLSKLTL NNNLVVNIDS TAFRNCSALK ELDLSSNALQ EVPDALKELS FLKTLDLGEN QISDFRNGSF KNLNQLTGLR LIDNNIGNLT RGMLWDLPSL QVLNLAKNKI QSIERGTFDR NTQLEAIRLD ENFLTDINGV FATLASLLWL NLSDNHLVWF DYAFIPSNLK WLDIHRNFIE HLGNYYKIQD EIRVKTLDAS HNRITEISPM SIPNSVELLF INNNFIKVVK PNTFLDKTSL ARVDMYANEL VNLDMNALRL SPVPPNRSLP EIYLGGNPFH CDCTMEWLHP VNNMSASRQY PRVMDLDNVM CKMTHSRGMA HMPLTRAKTS DFLCTYETHC FALCHCCDFD ACDCEMTCPN NCSCYHDQTW NTNVVDCSGQ NAIEIPHRIP MDATEVYLDG NDFRELQNHV FIGRKNMRVL FVNNSGIETI QNSTFNGLHT LQTLHLEDNK IYALEGYEFE HLSNLKELYL QNNVISSIGN KTLEPLKSLE ILRLDGNKLV VFPVWQLSSN SHLTEISLAN NRWSCRCKFL QEFTAWVADN APKVVDSASI QCYNGEATPQ RRDLDFNSTA CSDFYAGSSV IDSMLVSDYW KMVVVTLCIV ILLLLGVVLW FVFRDPVRVW LYSRYGIRLC SFRAAAAKQY EDRDKLYDAF VCYSPKDEEW VVQALAAELE SNFQLCLHYR DLPHAAYLQH AAPAVLEAAE ASRRVLIILT RNFLQTEWSR FELRQALHEA LKGRVFKLVI LEEGPLPEAE LDPELRPYLK TGNRVRWGEK RFWEKLRYAM PSGEPRGKIN ANYRRNINNY TIDSRVVANG THSHTYPEKI KTQGPPSPGM QMFPPPAYSA GAPHEPDDAN YSSATTATPS PRPMRRAQEP RPISDHIYSS IDSDYSTLER GGSGRRGPPW RPHVMMQTAG VNNGGQAYLV // ID D7LMK5_ARALL Unreviewed; 1196 AA. AC D7LMK5; DT 10-AUG-2010, integrated into UniProtKB/TrEMBL. DT 10-AUG-2010, sequence version 1. DT 28-FEB-2018, entry version 42. DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFH51938.1}; GN ORFNames=ARALYDRAFT_665161 {ECO:0000313|EMBL:EFH51938.1}; OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694}; RN [1] {ECO:0000313|Proteomes:UP000008694} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694}; RX PubMed=21478890; DOI=10.1038/ng.807; RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M., RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G., RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., RA Schneeberger K., Spannagl M., Wang X., Yang L., Nasrallah M.E., RA Bergelson J., Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., RA Van de Peer Y., Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.; RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome RT size change."; RL Nat. Genet. 43:476-481(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; GL348717; EFH51938.1; -; Genomic_DNA. DR RefSeq; XP_002875679.1; XM_002875633.1. DR STRING; 59689.Al_scaffold_0005_1196; -. DR EnsemblPlants; Al_scaffold_0005_1196; Al_scaffold_0005_1196; Al_scaffold_0005_1196. DR Gramene; Al_scaffold_0005_1196; Al_scaffold_0005_1196; Al_scaffold_0005_1196. DR KEGG; aly:ARALYDRAFT_665161; -. DR OrthoDB; EOG093611WO; -. DR Proteomes; UP000008694; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008694}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000008694}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 51 189 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1196 AA; 136600 MW; 33DFCD38334FCD1A CRC64; MNSASFFLVL VAAAIGFFML FRKFKFQQES KDTKASSLSL PSPPTSVSRI WKHDVFPSFH GADVRRTLLS HIMESFRRKG IDTFIDNNIE RSKPIGPELK EAIKGSKIAI VLLSKNYASS SWCLDELAEI MKCREVLGQI VMTIFYEVDP TDIKKQTGDF GKAFRKTCKG KTKEHIERWR KALKDVAIIA GEHSRNWSNE AEMIEKISID VSNMLNLSIP SRDFEGLVGM RAHMDRMEQF LRLDLDEVRM IGIWGPPGIG KTTIARFLLN QVSDRFQLST IMVNIKGCYP RPCFDEYTAQ LQLQTQMLSQ LIKHKDITIS HLGVAQERLK DKKVILVLDE VDHLGQLEAL AKEIQWFGPG SRIIITTEDL GVLKAHGINQ VYKVDFPSSD EAFQIFCMNA FGQKQPHEGF RNLAWEVIAL AGELPLGLKV LGSALRGMSK PEWERALPRL KASLDGKIGS IIQFSYDALC DEDKYLFLYI ACLFNFASVH RVEEALANKF SHVRHGLHVL HEKSLISIEY ERIQMHTLLQ QFGRKISRKQ FVHHGLTKHQ LLVGERDICD VFDYDTSDSR RFIGINLDLS KTEEELNISE KALERMHDFQ FVRIYGDDLG QTKRLQSVLQ GLIYHSQKIR SLNWRYFQDI CLPSTFNPEF LVELNLQDSK LQKLWEGTKQ LKNLKWMDLG GSRDLKELPD LSTATNLEEV DLQYCSSLVE LPSSIGNATK LERLYLRDCS SLVELPSIGN ASKLERLYLD NCSSLVKLPS SINASNLQEF IENASKLWEL NLLNCSSLLE LPPSIGTATN LKELYISGCS SLVKLPSSIG DMTKLKKFDL SNCSSLVEVP SAIGKLQKLS KLKMYGCSKL EVLPTNIDLE SLRTLDLRNC SQLKRFPEIS TNIAYLRLTG TAIKEVPLSI MSWSRLYDFG ISYFESLKEF PHALDIITQL QLNEDIQEVA PWVKGMSRLR VLRLYNCNNL VSLPQFSDSL AYIDADNCQS LERLDCTFNN PDIHLKFPKC FNLNQEARDL IMHTSTSEYA ILPGTQVPAC FNHRATAGGL VEFKLNESPL PRALRFKACF MFVKVNEETG DGWSSINVYH DIMDNQNGLN VRRKPRKCYI DRVLTEHIYI FEVRAEKVTS TELFFEVKTE NDSNWKIREC GLFQILEQKF KKFTFPIKTT NKQQFSGYDL NAFLPRHSML VFLDCG // ID E1BU20_CHICK Unreviewed; 622 AA. AC E1BU20; DT 02-NOV-2010, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 28-MAR-2018, entry version 50. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSGALP00000026211}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000026211, ECO:0000313|Proteomes:UP000000539}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000026211, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000026211, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|Ensembl:ENSGALP00000026211} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000026211}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AADN04000313; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9031.ENSGALP00000026211; -. DR PaxDb; E1BU20; -. DR Ensembl; ENSGALT00000026261; ENSGALP00000026211; ENSGALG00000016288. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; E1BU20; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Reactome; R-GGA-388844; Receptor-type tyrosine-protein phosphatases. DR Reactome; R-GGA-9007892; Interleukin-38 signaling. DR Proteomes; UP000000539; Chromosome 1. DR Bgee; ENSGALG00000016288; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 286 307 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 33 158 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 168 276 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 329 488 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 622 AA; 71561 MW; EB7FAF84F2769A92 CRC64; MWYKSSGPGD FEEPIAFDGT RMSKEEDSIW FRPTVVQDSG LYACVIRNST YCMKVSISLT VGENDTGLCY NSKMKYFEKA ELSKSKEISC PEIEDFLFPF REPEILWYKE CKSKTWRSSI GFIKDTLVIR EVREDDIGNY TCEVKYGIFV VRRTTELTVT APLTDKPPKL LHPLESKLTI QETQLGGSAN LTCRAFFGYS GDVSPLIYWM KGEKFIEDLD DSRVWESDIR VLKEHLGEQE VSISLILNSV EEGDLGNYSC YVENGNGRRH ASILLHKREL MYTVELAGGL GAILLLLVCL VTIYKCYKIE IMLFYRNHFG AEELDGDNKD YDAYLSYTKV DPDQWNQETG EEERFALEIL PDMLEKHYGY KLFIPDRDLI PTGTYIEDVA RCVDQSKRLI IVMTPSYVVR RGWSIFELET RLRNMLVTGE IKVILIECSE LRGVMNYQEV EALKHTIKLL TVIKWHGPKC NKLNSKFWKR LQYEMPFKRT EPITHEQVLD VSEQGPFGEL QTVSAISMAA ATSTALATAH PDLRSTFHNT YHSQMRQKHY YRSYEYDVPP TGTLPLTSIG NQHTYCNIPM TLINGQRPQT KTNREQNPDE AHTNSAILPL LPRETSISSV IW // ID E2B2I6_HARSA Unreviewed; 1275 AA. AC E2B2I6; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Protein toll {ECO:0000313|EMBL:EFN90101.1}; GN ORFNames=EAI_16095 {ECO:0000313|EMBL:EFN90101.1}; OS Harpegnathos saltator (Jerdon's jumping ant). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata; OC Vespoidea; Formicidae; Ponerinae; Ponerini; Harpegnathos. OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237}; RN [1] {ECO:0000313|EMBL:EFN90101.1, ECO:0000313|Proteomes:UP000008237} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN90101.1, RC ECO:0000313|Proteomes:UP000008237}; RX PubMed=20798317; DOI=10.1126/science.1192428; RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G., RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D., RA Wang J., Liebig J.; RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos RT saltator."; RL Science 329:1068-1071(2010). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; GL445145; EFN90101.1; -; Genomic_DNA. DR InParanoid; E2B2I6; -. DR OMA; PDAFRNC; -. DR Proteomes; UP000008237; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 7. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008237}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000008237}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 35 {ECO:0000256|SAM:SignalP}. FT CHAIN 36 1275 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003157771. FT TRANSMEM 1063 1086 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1116 1251 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1275 AA; 141965 MW; C3DA9A61A7441949 CRC64; MRGLVGGLEV PGRLLLLSLA AYYCLLPVCQ HHVFAVTSEL PPRLDLPEHC SWDSRQDGAL TCVHRHAGGN DSLRTNFSQV TSEYVTAMNV VCEDSDLGDE NGLLSVDGFL HLWRLRSLKL TGCKLMHWPA KLLSGLRDLR NLTVRTLNGR KTKYSLELES GAFDGTPQIE KLDLSWNNIW QIPDRLFCSL SNLVTLNISW NTLKDISELG FRDDGGVGGG AGGGGGGGGG GGGGGGGGGA AEAARGRLWE TRFPLDAEPR RHRAVRMTVT LTVDKDSETC RERAGPCSLD VQSLDVSNNQ ISVLSSYGFS SLKRLRVLNL SGNAISMVAD EALRGLRSLE SLDLSANRIV ALPTEMFRDA AKSLKELRLQ NNSISVLSPG LVADMNQLVA LDLSRNVLTS QWMNSATFSG LIRLVLLNLS HNRIDKLDPA LFKDLYTLQI LNLQFNEIET IPADTFSPMS NLHTLELAHN RLAYLDAYSL NGLFALSLLA LDSNLLEGIH PDAFRNCSSM QDLNLSGNNL DSVPVALKDM RILRTLDLGE NQIKSLGKHG FRGMSSLYGL RMMGNEITNV TQEDLAELPA LQILNLARNR IEYVEDGAFS ANPALQAIRL DSNLLQDMSS IFASTPDLLW LNMSDNMIAQ FNYSYLPEKL QWMDLHKNLV SDLGVAPRTL KLQTLDVSFN RLTRIHSRSI PDSIELLFVN DNNIQSVEPK TFFDKINLTR VDLYANMIVK MNLSALQLGQ VPASRQLPEF YIGGNPFICD CTTEWLQRIN SLTLRQHPRV MDLESVYCRL PYDRHKSFIP LLEAKPSQFL CTYKAHCFAL CHCCDFDACD CEMTCPSNCT CYHDQSWSAN VVDCSSSGYK SLPGRLPMDA TEVYLDGNNF GELNSHSFIG RKNMRILYAN DSNIIAVRNH TFSGLKRLLV LHLENNKIAV LNGVELMPLE NLKELYLQNN LLTYIDNGTF LPLRQLEVLR MENNRLGIFA LWQLEQNPYL IDIGLSSNPW SCECSYLDRV REWMSRNRLK INDWRSVTCS LGVPITLPAN GSAINCAALT GTTSAVEKRP IEAYLVLMLA TGLLIFVTVA VMCAVFRHRR ILRTWAASRC GLRACYKTAA FEDQEKPFDA YISYSAVDEA FVSAILVPSL ENSYRLCLHY RDLGAGSNVA DAVAEAADSS RRTILVLSKN FLHGEWARFE FKAALRDALK GRGRSVILLL VGGVCPRDLD ADLKKRISSH TVLVWGDKLF WQKLRFAMPE VSPLPVLERP LPLPPPPPPP GHQWT // ID E2RKX1_CANLF Unreviewed; 582 AA. AC E2RKX1; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 28-MAR-2018, entry version 54. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSCAFP00000003121}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSCAFP00000003121, GN ECO:0000313|VGNC:VGNC:41954}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000003121, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000003121, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000003121, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000003121} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000003121}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAEX03007425; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_538448.5; XM_538448.5. DR STRING; 9615.ENSCAFP00000003121; -. DR PaxDb; E2RKX1; -. DR Ensembl; ENSCAFT00000003362; ENSCAFP00000003121; ENSCAFG00000002134. DR GeneID; 481327; -. DR CTD; 8807; -. DR VGNC; VGNC:41954; IL18RAP. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; E2RKX1; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Reactome; R-CFA-9012546; Interleukin-18 signaling. DR Proteomes; UP000002254; Chromosome 10. DR Bgee; ENSCAFG00000002134; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 582 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013084770. FT TRANSMEM 359 385 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 148 231 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 251 353 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 406 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 582 AA; 66556 MW; D78476ACBF5682DC CRC64; MMLSLGWIFL WLVTGEKIKG MTTSDCLTKK LLWEYSSRSE EFVLFCDLTE LQKSHLHHRS QLLPTQSSEN LPCSGHEDLS DVQWYLQTQN GDSLGEITNN FPHITQDKSN LCFLTAGISN AGSYICRPRI RTPQDEACCI KTILEVKPKT NLSCIPNNSV SQQYLLFGSI AKINCPSLNC QSDAQSPEVT WYQNGKLLPK ERSNPIVVNE VYETNQGTYV CDYTQSDNTS SWIVRAVVQV RTIVKDTTLK PDILDPIKDV LEVELGKPLT LNCRARFGHQ RDFNPVVKWY VKDSDQESEV PTPETIRVKH TIKDEVYERV IHLKEVTQRD LRKKFICFAQ NSIGNTTQSI QLKEKKGVVF IYILLGTVMT LAGMLTAGAL LYMYWIEIVL LYRTYQSKDE TLGDKKVFDA FISYAKWSSF ENEATSSLSE EYLALNLFPE VLENKYGYNL CLLDRDVAPG GVYAEDIVNI IKKSRRGIFI LSPNYVNGPS IFELQAAVNL ALDDKTLKLI LIKFCSFQEP ESLPHLVKKA LRVLPTVTWR NLKSVPPNSR FWTQMRYHMP VKSSKGLRWN HLGSISKVFH WK // ID E7FGC6_DANRE Unreviewed; 547 AA. AC E7FGC6; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 28-MAR-2018, entry version 59. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000108832}; GN Name=LOC799279 {ECO:0000313|Ensembl:ENSDARP00000108832}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000108832, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000108832} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108832}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000108832, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108832, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|Ensembl:ENSDARP00000144331} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000144331}; RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CABZ01054964; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABZ01054965; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_001339654.4; XM_001339618.7. DR STRING; 7955.ENSDARP00000108832; -. DR Ensembl; ENSDART00000127085; ENSDARP00000108832; ENSDARG00000090844. DR Ensembl; ENSDART00000176601; ENSDARP00000144331; ENSDARG00000090844. DR GeneID; 799279; -. DR KEGG; dre:799279; -. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; E7FGC6; -. DR OMA; QKVGLHD; -. DR OrthoDB; EOG091G0GXW; -. DR PhylomeDB; E7FGC6; -. DR TreeFam; TF325519; -. DR Reactome; R-DRE-9020702; Interleukin-1 signaling. DR Proteomes; UP000000437; Chromosome 9. DR Bgee; ENSDARG00000090844; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 321 342 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 45 115 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 214 311 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 364 536 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 547 AA; 62418 MW; 8AA08DD30A3B5548 CRC64; MILLPRKPVM NFSTLYFRLI LLFALWISGS VTHLTHRKTY TFVAGLAFNL QCNRDSQNVT VSWTRVPSRS LESITGMNIK DNTLWFLPAD LTHQGSYSCF SRKGNDTWET IFEVSVSNET CPHWNRKDEL TSTAKLECFL PHIFKIDPQA QVTWRKNCQP LNMSNSKVLL VDRSTEMIGL LTCFVNFTFE GQNYLSAQTT EVYMGSTVDV VTPPKLIYPK PSQTHRVTLG QSYKINCKAL VGMNDDDDTD LYWYTDSDSL RLDFDLSRFK EGDQEYLLSV LSISEVTAEH LNINFTCKVD HPAGSDSGRV VLILASQNER YYWVGVGLVA LLILLLALLF LCRVDLVLAY RSVCSRSVAC SDGKWYDAYV SSLNVDPLSS SSAMTFALHF LPSVLEDLYG YRLFISGRDE LPGEAIQDVV SDRMNRSRRL IIILTSQSCS SPQKHASDKA QDSECKSSYE ALRSAYEQRV GLYDALVKQG LKVILVQVED GVEEHLLPES LKYISRTQGI LNWRENARER TNRRFWKHMR YRMPACQRRK GTDSMVL // ID F1LN63_RAT Unreviewed; 905 AA. AC F1LN63; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 28-MAR-2018, entry version 65. DE SubName: Full=Toll-like receptor 3 {ECO:0000313|Ensembl:ENSRNOP00000036680}; GN Name=Tlr3 {ECO:0000313|Ensembl:ENSRNOP00000036680, GN ECO:0000313|RGD:735171}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000036680, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000036680, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000036680, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000036680} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000036680}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSRNOP00000070415} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070415}; RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AABR07072514; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC108583; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_008769488.1; XM_008771266.2. DR RefSeq; XP_008769489.1; XM_008771267.2. DR UniGene; Rn.15273; -. DR STRING; 10116.ENSRNOP00000036680; -. DR Ensembl; ENSRNOT00000035781; ENSRNOP00000036680; ENSRNOG00000021726. DR Ensembl; ENSRNOT00000087986; ENSRNOP00000070415; ENSRNOG00000021726. DR GeneID; 364594; -. DR CTD; 7098; -. DR RGD; 735171; Tlr3. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; F1LN63; -. DR OMA; HLLKDPL; -. DR TreeFam; TF325595; -. DR Reactome; R-RNO-1679131; Trafficking and processing of endosomal TLR. DR Proteomes; UP000002494; Chromosome 16. DR Bgee; ENSRNOG00000021726; -. DR GO; GO:0009986; C:cell surface; IDA:RGD. DR GO; GO:0005737; C:cytoplasm; ISO:RGD. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0005622; C:intracellular; IDA:RGD. DR GO; GO:0005765; C:lysosomal membrane; ISO:RGD. DR GO; GO:0003725; F:double-stranded RNA binding; IDA:RGD. DR GO; GO:0042802; F:identical protein binding; ISO:RGD. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0035690; P:cellular response to drug; IEP:RGD. DR GO; GO:0071359; P:cellular response to dsRNA; IEP:RGD. DR GO; GO:0071360; P:cellular response to exogenous dsRNA; IMP:RGD. DR GO; GO:0035458; P:cellular response to interferon-beta; IEP:RGD. DR GO; GO:0071346; P:cellular response to interferon-gamma; IEP:RGD. DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD. DR GO; GO:0006952; P:defense response; ISO:RGD. DR GO; GO:0051607; P:defense response to virus; ISO:RGD. DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:RGD. DR GO; GO:0007252; P:I-kappaB phosphorylation; ISO:RGD. DR GO; GO:0008584; P:male gonad development; IEP:RGD. DR GO; GO:0001774; P:microglial cell activation; IDA:RGD. DR GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0097527; P:necroptotic signaling pathway; ISO:RGD. DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEP:RGD. DR GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; ISO:RGD. DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:RGD. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; ISO:RGD. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; ISO:RGD. DR GO; GO:0032728; P:positive regulation of interferon-beta production; ISO:RGD. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; ISO:RGD. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:RGD. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD. DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; ISO:RGD. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:RGD. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; ISO:RGD. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD. DR GO; GO:0032481; P:positive regulation of type I interferon production; ISO:RGD. DR GO; GO:0034346; P:positive regulation of type III interferon production; ISO:RGD. DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; ISO:RGD. DR GO; GO:0043331; P:response to dsRNA; IDA:RGD. DR GO; GO:0043330; P:response to exogenous dsRNA; ISO:RGD. DR GO; GO:0009615; P:response to virus; IEP:RGD. DR GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IEA:InterPro. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IDA:RGD. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027173; TLR3. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44599; PTHR44599; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 7. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 15. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1LN63}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 7 24 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 705 726 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 755 859 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 905 AA; 103015 MW; 64793B5C49AC4398 CRC64; MKGRSSYLIY SFGGLLSLWI LVVSSTNQCT VRYNVADCSH LKLTHIPDDL PSNITVLNLT HNQLRGLPPA NFTRYSQLAL LDAGFNSISK LEPELCQILP LLKVLNLQHN ELSQISDQTF AFCTNLTELH LMSNSIRKIK SNPFKNQKSL IKLDLSRNGL SSTKLGTGVQ LENLQELLLA KNKIFALRSE ELDFLGNSSL QKLDLSSNPL KEFSPGCFHA IGKLFVLLLN NAQLNLNLTE KLCWELSNTS IQNLSLANNQ LLATSNSTFS GLKQTNLTSL DLSYNSLRYV GNDAFSWLPH LKYLSLEYNN IQSLTPHSFR GLSNLRYLSL KRAFTKQSVA LASHPNIDDF SFQWLKCLEH LNMDDNTIPG IKSNTFTGLV SLKYLSLSKT FTGLQTLTNE TFVSLTHSPL LTLNLTKNHI SKIASGTFSW LGQLRILDLG LNEIEQELTG QEWRGLGNIF EIYLSYNKYL QLTSKSFTLV PSLQRLMLRR VALKSVDISP SPFRPLYNLT ILDLSNNNIA NLNEDLLEGL ENLEILDFQH NNLARLWKHA NPGGPVNFLK GLSHLHILNL ESNGLDEIPV KVFKNLFELK SINLGLNNLN TLLPSIFDDQ TSLRSLNLQK NLITSVEKSV FGPAFHNLNS LDMSFNPFDC TCESIAWFVT WLNQTHTNIP ELSTHYLCNT PQRYHGLPVK LFDTSSCKDS APFQLLFIIN TSTLLTFILA VLLIHFEGWR ISFYWNVSVH RILGFKEIDA QGEQFEYTAY IIHAQKDRDW VWEHFSPMEE QDQSLKFCLE ERDFEAGVLG LEAIVNSIKR SRKIIFVITH HLLKDPLCRR FKVHHAVQQA IEQNLDSIIL IFLQNIPDYK LNHALCLRRG MFKSHCILNW PIQKERINAF HHKLQVALGS RNSAH // ID F1NBN5_CHICK Unreviewed; 1051 AA. AC F1NBN5; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 28-MAR-2018, entry version 61. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSGALP00000035830}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSGALP00000035830}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000035830, ECO:0000313|Proteomes:UP000000539}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000035830, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000035830, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|Ensembl:ENSGALP00000035830} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000035830}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AADN04000416; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_015129128.1; XM_015273642.1. DR RefSeq; XP_015129133.1; XM_015273647.1. DR RefSeq; XP_015129137.1; XM_015273651.1. DR UniGene; Gga.22176; -. DR Ensembl; ENSGALT00000036619; ENSGALP00000035830; ENSGALG00000016590. DR GeneID; 418638; -. DR CTD; 51284; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR Reactome; R-GGA-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-GGA-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-GGA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-GGA-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-GGA-975155; MyD88 dependent cascade initiated on endosome. DR Proteomes; UP000000539; Chromosome 1. DR Bgee; ENSGALG00000016590; -. DR ExpressionAtlas; F1NBN5; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 1051 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003266952. FT TRANSMEM 842 866 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 891 1038 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1051 AA; 121386 MW; 315C2496937F676E CRC64; MSSVWVHHAR TSNALLFVLL FLFPMLLSGR WFPKTLPCDV EAFESTVRVD CSDRRLKEVP RGIPGNATNL TLTINHIPRI SPASFTQLEN LVEIDFRCNC VPPRLGPKDN VCVTPPSIEN GSFAALTRLK SLYLDANQLS KIPRGLPATL RLLSLEANNI FSIKKNTFSE LRNIELLYLG QNCYYRNPCN VSFEIEETAF LNLKNLTVLS LKSNNLTFIP PNLSSTLKEL YIYNNRIQEV QEHDLSNLYN LEILDLSGNC PRCYNAPYPC TPCPNISIKI HSKAFYSLKK LRILRLHSNS LQSIPSSWFK NIKNLKNLDL SQNFLIKEIG DAEFLKLIPS LVELDLSFNF ELQMYSPFLN LSKTFSCLSN LETLRIKGYV FKELREENLD PLLNLRNLTV LDLGTNFIKI ADLRVFKKFR SLKIIDLSMN KISPSSGEGN FYGFCSDHRI TVEQYSRHVL QEMHYFRYDE YGRSCKSKDK EADSYQPLVN GDCMSYGETL DLSRNNIFFV NSIDFQDLSF LKCLNLSGNA ISQTLNGSEF YYLSGLKYLD FSNNRIDLLY STAFKELKFL EILDLSNNKH YFLAEGVSHV LSFMKNLAYL KKLMMNENEI STSISTGMES QSLQTLEFRG NRLDIFWSDG KKEYLSFFKN LTNLEQLDIS SNMLNFLPPD VFEAMPPELK ILNLTSNRLH TFNWGKLHLL TKLITLDLSN NLLTTVPRKL SNCTSTLQEL ILRNNRITRI TKYFLRGAIQ LTYLDLSSNK IQIIKKSSFP ENIINNLRML LLHNNPFKCN CDAVWFVGWI NQTQVAIPLL ATDVTCAGPG AHKGRSLVFL DLNTCELDTS YFIMYALSTS AVLCLMMFAV MSHLYFWDVW YSYHYCTAKL KGYRRIPLPD ACYDAFIAYD NTDLAVNEWV MTELVEKLED QKARQFNLCL EERDWLPGQP VFDNLSQSIQ LSKKTIFVLT NKYIKSGTFK TTFYMAHQRL LDEKIDVIIL IFLEKVLQKS RYVQLRKRLC RSSVLEWPTN PRSQPYFWQR LKNAIAMNNT LSYNKLLQET V // ID F1NLC3_CHICK Unreviewed; 533 AA. AC F1NLC3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 3. DT 28-MAR-2018, entry version 52. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSGALP00000029597}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSGALP00000029597}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000029597, ECO:0000313|Proteomes:UP000000539}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000029597, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000029597, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|Ensembl:ENSGALP00000029597} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000029597}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AADN04000082; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9031.ENSGALP00000029597; -. DR PaxDb; F1NLC3; -. DR Ensembl; ENSGALT00000030235; ENSGALP00000029597; ENSGALG00000016785. DR eggNOG; ENOG410IPTT; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F1NLC3; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000000539; Chromosome 1. DR Bgee; ENSGALG00000016785; -. DR ExpressionAtlas; F1NLC3; baseline and differential. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0002113; F:interleukin-33 binding; IEA:Ensembl. DR GO; GO:0002114; F:interleukin-33 receptor activity; IEA:Ensembl. DR GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IEA:Ensembl. DR GO; GO:0090197; P:positive regulation of chemokine secretion; IEA:Ensembl. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 533 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003270809. FT TRANSMEM 323 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 103 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 106 194 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 207 314 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 368 523 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 533 AA; 61771 MW; 5AB391A6EA41E5F8 CRC64; MMVYVHLIFL SVFLPVSVIS ESYDTMEGEA LVVRCPHSDL SAKVTWHHTG TRKRIPEEEE GSRVFSKGIF LWFLPTSLED SGNYTCVINY PDGSKKERKM NVQVHPYKQG TCFPSRILYA NETRKGKISC PTFRNYENAT IIQWYKDCRP IQGERYFMHD PYIFIENLNK EDDGYYTCQF TYTHRGRVFN VSATRIFVSE AKHSSLPVQI LFPKDEDVLE VELGAAFSLK CQARLGIKKQ PIAVVTWDVN KMPAEYANEE KIRQEFSYFE GQHQEYYGEA TLTISNIEHT DLQSSFSCVA MNEMGNTRTT VTLRLKKKSG PNVLMIAGFL VFLMSVAVSV VLYQSFRVDI VLLYRDLFQA YSVKDDGKIY DAYVIYPRSH STEATFVEYF VYQIMPDILE NKCGYTLCIY GRDTYPGEDK ANAIEKRIQK SRRLIILLTQ QLINCQELNY DQHIALYNAL IQNDTKVILL EMEKMGSYEN LQESLRYIIK QQGTVKWKEQ HTVHPQSSNS KFWKHVRYHM PVTLRSSDSA NAG // ID F1P4S8_CHICK Unreviewed; 486 AA. AC F1P4S8; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 3. DT 28-MAR-2018, entry version 44. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSGALP00000027051}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSGALP00000027051}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000027051, ECO:0000313|Proteomes:UP000000539}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000027051, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000027051, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|Ensembl:ENSGALP00000027051} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000027051}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AADN04000082; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSGALT00000027102; ENSGALP00000027051; ENSGALG00000016785. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000000539; Chromosome 1. DR Bgee; ENSGALG00000016785; -. DR ExpressionAtlas; F1P4S8; baseline and differential. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 486 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003271020. FT DOMAIN 15 103 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 106 194 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 207 314 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 321 476 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 486 AA; 56551 MW; 60064B47B57C4DE5 CRC64; MMVYVHLIFL SVFLPVSVIS ESYDTMEGEA LVVRCPHSDL SAKVTWHHTG TRKRIPEEEE GSRVFSKGIF LWFLPTSLED SGNYTCVINY PDGSKKERKM NVQVHPYKQG TCFPSRILYA NETRKGKISC PTFRNYENAT IIQWYKDCRP IQGERYFMHD PYIFIENLNK EDDGYYTCQF TYTHRGRVFN VSATRIFVSE AKHSSLPVQI LFPKDEDVLE VELGAAFSLK CQARLGIKKQ PIAVVTWDVN KMPAEYANEE KIRQEFSYFE GQHQEYYGEA TLTISNIEHT DLQSSFSCVA MNEMGNTRTT VTLRLKKKYG KIYDAYVIYP RSHSTEATFV EYFVYQIMPD ILENKCGYTL CIYGRDTYPG EDKANAIEKR IQKSRRLIIL LTQQLINCQE LNYDQHIALY NALIQNDTKV ILLEMEKMGS YENLQESLRY IIKQQGTVKW KEQHTVHPQS SNSKFWKHVR YHMPVTLRSS DSANAG // ID F1PSF2_CANLF Unreviewed; 553 AA. AC F1PSF2; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000003133}; GN Name=IL1RL2 {ECO:0000313|Ensembl:ENSCAFP00000003133}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000003133, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000003133, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000003133, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000003133} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000003133}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAEX03007426; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1PSF2; -. DR STRING; 9615.ENSCAFP00000003133; -. DR PaxDb; F1PSF2; -. DR Ensembl; ENSCAFT00000003375; ENSCAFP00000003133; ENSCAFG00000002145. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F1PSF2; -. DR OMA; DNTNLRC; -. DR OrthoDB; EOG091G03IT; -. DR TreeFam; TF325519; -. DR Reactome; R-CFA-9007892; Interleukin-38 signaling. DR Reactome; R-CFA-9014826; Interleukin-36 pathway. DR Proteomes; UP000002254; Chromosome 10. DR Bgee; ENSCAFG00000002145; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 553 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003267585. FT TRANSMEM 337 360 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 16 113 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 141 215 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 382 540 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 553 AA; 62839 MW; 66E87A43BD1F190B CRC64; RGMLALLLCG VSVALPSFVR ADACKNVSMQ NEAPSAGQPF AFNCTYPPLT SGKVHVTWYK YPSRIPISKN TQSRIHQEQN WILFLPLTPE DSGIYQCVIN STNTCHRIHV NLTVLRKYWC DISGNGQLIL SDEYKQILHA GRDDSLTCHL NFPQSCVLDS ITWYKDCKEI KEGRFIRWGI KLSVSNVSAE DGGNYACQAR LTHTGKHYTV LNSITVRIKT NGYAERIPKI IYPKNNSIEV QLGSALTVDC NITDTRDNTN LRCWRVNNTL VDDYYNESKR IREGSESHIP FQKHIFYTVN ITFLEVKMED YGHPFICHAG VSAAYFILKL PAPDVRAYLI GGLLALVGAA VSVTYIYNIF KIDIVLWYRS ACHSPGTKED GKLYDAYVLY PKPQGEIQSH DVDTLVLKIL PEVLERQCGY KLFIFGRDEF PGQAVANVID ENIKLCRRLI IILVPESLSF DLLKNMSEEQ IAVYNALIQD GMKVILIELE KVKDYTAMPE SIQYIKQKHG AIQWSGDITQ QSQCAKTKFW KKVRYHMPPK RLPPSSAQLL KHT // ID F1PYR3_CANLF Unreviewed; 437 AA. AC F1PYR3; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 2. DT 28-MAR-2018, entry version 48. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCAFP00000020084}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000020084, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000020084, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000020084, RC ECO:0000313|Proteomes:UP000002254}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F., RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T., RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000020084} RP IDENTIFICATION. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000020084}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAEX03026237; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1PYR3; -. DR STRING; 9615.ENSCAFP00000020084; -. DR PaxDb; F1PYR3; -. DR Ensembl; ENSCAFT00000021628; ENSCAFP00000020084; ENSCAFG00000013632. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F1PYR3; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Reactome; R-CFA-388844; Receptor-type tyrosine-protein phosphatases. DR Reactome; R-CFA-9007892; Interleukin-38 signaling. DR Proteomes; UP000002254; Chromosome X. DR Bgee; ENSCAFG00000013632; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002254}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002254}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50249 MW; FEC52E742A9BC580 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID F1R2P4_DANRE Unreviewed; 992 AA. AC F1R2P4; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 2. DT 28-MAR-2018, entry version 55. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000107821}; GN Name=tlr8a {ECO:0000313|Ensembl:ENSDARP00000107821, GN ECO:0000313|ZFIN:ZDB-GENE-040219-13}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000107821, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000107821} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107821}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000107821, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107821, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 7955.ENSDARP00000103011; -. DR PaxDb; F1R2P4; -. DR Ensembl; ENSDART00000124995; ENSDARP00000107821; ENSDARG00000090119. DR ZFIN; ZDB-GENE-040219-13; tlr8a. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; F1R2P4; -. DR OMA; DISENWN; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF351113; -. DR Reactome; R-DRE-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-DRE-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-DRE-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-DRE-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-DRE-975155; MyD88 dependent cascade initiated on endosome. DR Proteomes; UP000000437; Unplaced. DR Bgee; ENSDARG00000090119; -. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro. DR GO; GO:0004872; F:receptor activity; IBA:GO_Central. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:InterPro. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 780 805 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 829 976 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 992 AA; 114066 MW; 006F25FE3A5EAB08 CRC64; KTQPCDIHEN ITAETVVVNC RGRKLKVLPQ FLANTTYIDL SENYIKNLTV QSFHGLENLT LLNLNWLNQN REVVIAKGVF SNLTKLRVLD LNGIKLKYIP KDIPKNLEKL SLVENKITWI NLTTFEHVKN LSVLYLSNNC YYWNPCSRRY RIEKGSLSYL VNLKRLTLSF NNLTQVPIGL PVSLERLELG SNSLTYIGEH DFRGLFNLTV LKIQGNCPRC HTAPYPCIPC KNTSIEIHPQ AFSDLRNLHI LHLAGNSIKS INPAWFANLS NLQQLFLSFN LLFSAITDPA DTVFLGNLPL LTKLDLSYNF AFKTYPLTVV LSPGFANLTS LRSLHLRGLV FRKIQKDTFK SLFDLQHLNV LDVGVNFIVF ATSYIFQHVR LLYLAENRLY PVTVNGELSK ATFVGSNHRS IMPLMAEPLD TFDAPKNLVK SECYNAGRVL DLSRNNLFLI SPEQFDTYGN ISCLNLSRNG FSTAPNGSEF TSLPNLKYLD LSFNKVDLAY DNAFRELQSL EVLDISYNSH YFTVAGVTHN MMFLQYLPSL KVLNMSFNSI NTLTTKTMSS KSLRELQFRG NKLGRMWRDK DNTYVMIFKN FTNLIHLDIS NNSIGKIPYT VYTQLPITIQ RLQMSHNQLA NINWTMLRRF QNLRELILHD NNIIEIASNL SVDVPSLELL NLQHNRISKL AIGFLQGVVN LKELDLSYNY LITVNQSTFP TESDLKMLWL HGNPFHCTCN LLEFVLWILD TNVKIPRLVT GVTCTMPEER KGLAVIKFDI QECIDDQLAF VAYFISAACI ICTTFAAITM HLFYWDVSYL YYYLKARFTG YQQLSSESCI YDAFITYDTK DPQVSDWVLN HLRVQLEERS ELFLPICLEE RDWIPGSPVL DSLTQSIQNS RKTVFVLTEG YVNSGSFKLA VFLAHQRLLE ENEDVIVLLL LEPVLQHSHF VRLRRRLCAR SILEWPHSSS AEAWFWQSLR NAIRVDNQAL YSELYSRYFT TK // ID F4I270_ARATH Unreviewed; 1400 AA. AC F4I270; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 28-FEB-2018, entry version 55. DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:AEE34948.1}; GN OrderedLocusNames=At1g69550 {ECO:0000313|Araport:AT1G69550, GN ECO:0000313|EMBL:AEE34948.1}; GN ORFNames=F10D13.24 {ECO:0000313|EMBL:AEE34948.1}, GN F10D13_24 {ECO:0000313|EMBL:AEE34948.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEE34948.1, ECO:0000313|Proteomes:UP000006548}; RN [1] {ECO:0000313|EMBL:AEE34948.1, ECO:0000313|Proteomes:UP000006548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RX PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., RA Dunn P., Etgu P., Feldblyum T.V., Feng J., Fong B., Fujii C.Y., RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., RA Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., RA Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., RA Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., RA Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., RA Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., RA Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., RA Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis RT thaliana."; RL Nature 408:816-820(2000). RN [2] {ECO:0000313|EMBL:AEE34948.1, ECO:0000313|Proteomes:UP000006548} RP GENOME REANNOTATION. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CP002684; AEE34948.1; -; Genomic_DNA. DR RefSeq; NP_564971.2; NM_105624.5. DR UniGene; At.45170; -. DR ProteinModelPortal; F4I270; -. DR STRING; 3702.AT1G69550.1; -. DR PaxDb; F4I270; -. DR EnsemblPlants; AT1G69550.1; AT1G69550.1; AT1G69550. DR GeneID; 843291; -. DR Gramene; AT1G69550.1; AT1G69550.1; AT1G69550. DR KEGG; ath:AT1G69550; -. DR Araport; AT1G69550; -. DR TAIR; locus:2007121; AT1G69550. DR eggNOG; ENOG410J606; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; F4I270; -. DR OMA; ELKCLVM; -. DR OrthoDB; EOG09360FZ0; -. DR Proteomes; UP000006548; Chromosome 1. DR ExpressionAtlas; F4I270; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 7. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006548}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006548}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 7 24 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 78 216 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1400 AA; 155202 MW; 495CB20FE2F042F1 CRC64; MLMDSSFFLT IVAAAFAIGF FIFLRKLRIH QENEDVGSSS TSPPSSLASS TSPPSTLSSS TSHPSSSTSP PSSLSCTGTH HVFPSFRGDD VRRNFLSHIQ KEFRRKGITP FIDNEIRRGE SIGPELIKAI RESKIAIVLL SRNYASSKWC LEELVEIMKC KKEFGLTVFA IFYEVDPSHV KKLTGEFGAV FQKTCKGRTK ENIMRWRQAF EEVATIAGYD SRNWENEAAM IEEIAIEISK RLINSSPFSG FEGLIGMKAH IEKMKQLLCL DSTDERRTVG ISGPSGIGKS TIARVLHNQI SDGFQMSVFM KFKPSYTRPI CSDDHDVKLQ LEQQFLAQLI NQEDIKIHQL GTAQNFVMGK KVLIVLDGVD QLVQLLAMPK AVCLGPGSRI IITTQDQQLL KAFQIKHIYN VDFPPDHEAL QIFCIHAFGH DSPDDGFEKL ATKVTRLAGN LPLGLRVMGS HFRGMSKEDW KGELPRLRIR LDGEIGSILK FSYDVLDDED KDLFLHIACF FNDEGIDHTF EDTLRHKFSN VQRGLQVLVQ RSLISEDLTQ PMHNLLVQLG REIVRNQSVY EPGKRQFLVD GKEICEVLTS HTGSESVIGI NFEVYWSMDE LNISDRVFEG MSNLQFFRFD ENSYGRLHLP QGLNYLPPKL RILHWDYYPM TSLPSKFNLK FLVKIILKHS ELEKLWEGIQ PLVNLKVMDL RYSSHLKELP NLSTAINLLE MVLSDCSSLI ELPSSIGNAT NIKSLDIQGC SSLLKLPSSI GNLITLPRLD LMGCSSLVEL PSSIGNLINL PRLDLMGCSS LVELPSSIGN LINLEAFYFH GCSSLLELPS SIGNLISLKI LYLKRISSLV EIPSSIGNLI NLKLLNLSGC SSLVELPSSI GNLINLKKLD LSGCSSLVEL PLSIGNLINL QELYLSECSS LVELPSSIGN LINLKTLNLS ECSSLVELPS SIGNLINLQE LYLSECSSLV ELPSSIGNLI NLKKLDLSGC SSLVELPLSI GNLINLKTLN LSECSSLVEL PSSIGNLINL QELYLSECSS LVELPSSIGN LINLKKLDLS GCSSLVELPL SIGNLINLKT LNLSGCSSLV ELPSSIGNLN LKKLDLSGCS SLVELPSSIG NLINLKKLDL SGCSSLVELP LSIGNLINLQ ELYLSECSSL VELPSSIGNL INLQELYLSE CSSLVELPSS IGNLINLKKL DLNKCTKLVS LPQLPDSLSV LVAESCESLE TLACSFPNPQ VWLKFIDCWK LNEKGRDIIV QTSTSNYTML PGREVPAFFT YRATTGGSLA VKLNERHCRT SCRFKACILL VRKGDKIDCE EWGSVYLTVL EKQSGRKYSL ESPTLYPLLT EHLYTFEIEA KGVKSVELVI KFQFGRKKWE IGECGIRPLL EEDTHVESSI // ID F4J3L8_ARATH Unreviewed; 867 AA. AC F4J3L8; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 28-MAR-2018, entry version 50. DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:AEE74054.1}; GN OrderedLocusNames=At3g04220 {ECO:0000313|Araport:AT3G04220, GN ECO:0000313|EMBL:AEE74054.1}; GN ORFNames=T6K12.16 {ECO:0000313|EMBL:AEE74054.1}, GN T6K12_16 {ECO:0000313|EMBL:AEE74054.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEE74054.1, ECO:0000313|Proteomes:UP000006548}; RN [1] {ECO:0000313|EMBL:AEE74054.1, ECO:0000313|Proteomes:UP000006548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RX PubMed=11130713; DOI=10.1038/35048706; RG European Union Chromosome 3 Arabidopsis Sequencing Consortium; RG Institute for Genomic Research; RG Kazusa DNA Research Institute; RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., RA Fartmann B., Valle G., Blocker H., Perez-Alonso M., Obermaier B., RA Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., RA De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P., RA Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., RA Schafer M., Muller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., RA Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., RA Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., RA Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., RA Kauer G., Lohnert T.H., Nordsiek G., Reichelt J., Scharfe M., RA Schon O., Bargues M., Terol J., Climent J., Navarro P., Collado C., RA Perez-Perez A., Ottenwalder B., Duchemin D., Cooke R., Laudie M., RA Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., RA Alcaraz J.P., Cottet A., Casacuberta E., Monfort A., Argiriou A., RA flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., RA Rudd S., Zaccaria P., Mewes H.W., Mayer K.F., Kaul S., Town C.D., RA Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., RA Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., RA Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., RA Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., RA Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., RA Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., RA Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., RA Tabata S.; RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis RT thaliana."; RL Nature 408:820-822(2000). RN [2] {ECO:0000313|EMBL:AEE74054.1, ECO:0000313|Proteomes:UP000006548} RP GENOME REANNOTATION. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RA Lavstsen T., Jespersen J.S.; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CP002686; AEE74054.1; -; Genomic_DNA. DR RefSeq; NP_187072.2; NM_111293.2. DR UniGene; At.51214; -. DR ProteinModelPortal; F4J3L8; -. DR STRING; 3702.AT3G04220.1; -. DR PaxDb; F4J3L8; -. DR EnsemblPlants; AT3G04220.1; AT3G04220.1; AT3G04220. DR GeneID; 819577; -. DR Gramene; AT3G04220.1; AT3G04220.1; AT3G04220. DR Araport; AT3G04220; -. DR TAIR; locus:2103050; AT3G04220. DR eggNOG; COG4886; LUCA. DR InParanoid; F4J3L8; -. DR OMA; RHITIVE; -. DR OrthoDB; EOG09360FZ0; -. DR Proteomes; UP000006548; Chromosome 3. DR ExpressionAtlas; F4J3L8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006548}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006548}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 6 28 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 61 199 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 867 AA; 98511 MW; 76167C0DA386AC10 CRC64; MDSSFLLETV AAATGFFTLL GTILFMVYRK FKDHRENKEN DSSSSTQPSP SPPLSSLSLT RKYDVFPSFR GEDVRKDFLS HIQKEFQRQG ITPFVDNNIK RGESIGPELI RAIRGSKIAI ILLSKNYASS SWCLDELVEI IKCKEEMGQT VIVIFYKVDP SLVKKLTGDF GKVFRNTCKG KERENIERWR EAFKKVATIA GYDSRKWDNE SGMIEKIVSD ISEMLNHSTP SRDFDDLIGM GDHMEKMKPL LDIDSDEMKT IGIWGPPGVG KTTIARSLYN QHSDKFQLSV FMESIKTAYT IPACSDDYYE KLQLQQRFLS QITNQENVQI PHLGVAQERL NDKKVLVVID DVNQSVQVDA LAKENDWLGP GSRIIITTQD RGILRAHGIE HIYEVDYPNY EEALQIFCMH AFGQKSPYDG FEELAQQVTT LSGRLPLGLK VMGSYFRGMT KQEWTMALPR VRTHLDGKIE SILKLSYDAL CDVDKSLFLH LACSFHNDDT ELVEQQLGKK FSDLRQGLHV LAEKSLIHMD LRLIRMHVLL AQLGREIVRK QSIHEPGQRQ FLVDATDIRE VLTDDTGSRS VIGIDFDFNT MEKELDISEK AFRGMSNLQF IRIYGDLFSR HGVYYFGGRG HRVSLDYDSK LHFPRGLDYL PGKLSKLEKL WEGIQPLRNL EWLDLTCSRN LKELPDLSTA TNLQRLSIER CSSLVKLPSS IGEATNLKKI NLRECLSLVE LPSSFGNLTN LQELDLRECS SLVELPTSFG NLANVESLEF YECSSLVKLP STFGNLTNLR VLGLRECSSM VELPSSFGNL TNLQVLNLRK CSTLVELPSS FVNLTNLENL DLRDCSSLLP SSFGNVTYLK RLKFYKC // ID F4JNB8_ARATH Unreviewed; 1404 AA. AC F4JNB8; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 28-FEB-2018, entry version 57. DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:AEE83827.1}; GN Name=RPP5 {ECO:0000313|EMBL:AEE83827.1}; GN OrderedLocusNames=At4g16950 {ECO:0000313|Araport:AT4G16950, GN ECO:0000313|EMBL:AEE83827.1}; GN ORFNames=Dl4505c {ECO:0000313|EMBL:AEE83827.1}, GN FCAALL.315 {ECO:0000313|EMBL:AEE83827.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEE83827.1, ECO:0000313|Proteomes:UP000006548}; RN [1] {ECO:0000313|EMBL:AEE83827.1, ECO:0000313|Proteomes:UP000006548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RX PubMed=10617198; DOI=10.1038/47134; RG EU; RG CSHL and WU Arabidopsis Sequencing Project; RA Mayer K., Schuller C., Wambutt R., Murphy G., Volckaert G., Pohl T., RA Dusterhoft A., Stiekema W., Entian K.D., Terryn N., Harris B., RA Ansorge W., Brandt P., Grivell L., Rieger M., Weichselgartner M., RA de Simone V., Obermaier B., Mache R., Muller M., Kreis M., Delseny M., RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., RA Portatelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., RA Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.A., RA McCullagh B., Bilham L., Robben J., Van der Schueren J., RA Grymonprez B., Chuang Y.J., Vandenbussche F., Braeken M., Weltjens I., RA Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., RA Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., RA van Staveren M., Dirske W., Mooijman P., Klein Lankhorst R., Rose M., RA Hauf J., Kotter P., Berneiser S., Hempel S., Feldpausch M., RA Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., RA Villarroel R., De Clercq R., Van Montagu M., Rogers J., Cronin A., RA Quail M., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., RA Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., RA Benes V., Rechmann S., Borkova D., Blocker H., Scharfe M., Grimm M., RA Lohnert T.H., Dose S., de Haan M., Maarse A., Schafer M., RA Muller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., RA Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., RA Piravandi E., Massenet O., Quigley F., Clabauld G., Mundlein A., RA Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., RA Chefdor F., Cooke R., Berger C., Montfort A., Casacuberta E., RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., RA Frishman D., Haase D., Lemcke K., Mewes H.W., Stocker S., Zaccaria P., RA Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., RA Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sehkon M., RA Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., RA Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., RA Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., RA Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., RA Fulton L., Mardis E., Dante M., Pepin K., Hillier L., Nelson J., RA Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., RA Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., RA O'Shaughnessy A., Rodriguez M., Hoffmann J., Till S., Granat S., RA Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., RA Marra M., Martienssen R., McCombie W.R.; RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis RT thaliana."; RL Nature 402:769-777(1999). RN [2] {ECO:0000313|EMBL:AEE83827.1, ECO:0000313|Proteomes:UP000006548} RP GENOME REANNOTATION. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CP002687; AEE83827.1; -; Genomic_DNA. DR RefSeq; NP_849398.1; NM_179067.2. DR UniGene; At.33039; -. DR UniGene; At.43768; -. DR UniGene; At.4449; -. DR UniGene; At.67198; -. DR UniGene; At.71837; -. DR ProteinModelPortal; F4JNB8; -. DR SMR; F4JNB8; -. DR EnsemblPlants; AT4G16950.2; AT4G16950.2; AT4G16950. DR GeneID; 827403; -. DR Gramene; AT4G16950.2; AT4G16950.2; AT4G16950. DR Araport; AT4G16950; -. DR eggNOG; ENOG410IGA8; Eukaryota. DR eggNOG; COG4886; LUCA. DR PhylomeDB; F4JNB8; -. DR Proteomes; UP000006548; Chromosome 4. DR ExpressionAtlas; F4JNB8; baseline and differential. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 3. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006548}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000006548}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 10 152 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1404 AA; 158947 MW; 1BF135E7368BFF60 CRC64; MAASSSSGRR RYDVFPSFSG VDVRKTFLSH LIEALDGKSI NTFIDHGIER SRTIAPELIS AIREARISIV IFSKNYASST WCLNELVEIH KCFNDLGQMV IPVFYDVDPS EVRKQTGEFG KVFEKTCEVS KDKQPGDQKQ RWVQALTDIA NIAGEDLLNG PNEAHMVEKI SNDVSNKLIT RSKCFDDFVG IEAHIEAIKS VLCLESKEAR MVGIWGQSGI GKSTIGRALF SQLSIQFPLR AFLTYKSTSG SDVSGMKLSW EKELLSEILG QKDIKIEHFG VVEQRLKHKK VLILLDDVDN LEFLKTLVGK AEWFGSGSRI IVITQDRQFL KAHDIDLVYE VKLPSQGLAL TMLCRSAFGK DSPPDDFKEL AFEVAKLAGH LPLGLNVLGS SLRRRGKKEW MEMMPRLRNG LNGDIMKTLR VSYDRLHQKD QDMFLCIACL FNGFEVSYVK DLLEDNVGLT MLSEKSLIRI TPDGHIEMHN LLEKLGREID RAKSKGNPGK RQFLTNFEDI HEVVTEKTGT ETLLGIRLPF EEYFSTRPLL IDKESFKGMR NLQYLKIGDW SDGGQPQSLV YLPLKLRLLD WDDCPLKSLP STFKAEYLVN LIMKYSKLEK LWEGTLPLGS LKKMNLLCSK NLKEIPDLSN ARNLEELDLE GCESLVTLPS SIQNAIKLRK LHCSGVILID LKSLEGMCNL EYLSVDCSRV EGTQGIVYFP SKLRLLLWNN CPLKRLHSNF KVEYLVKLRM ENSDLEKLWD GTQPLGRLKQ MFLRGSKYLK EIPDLSLAIN LEEVDICKCE SLVTFPSSMQ NAIKLIYLDI SDCKKLESFP TDLNLESLEY LNLTGCPNLR NFPAIKMGCS DVDFPEGRNE IVVEDCFWNK NLPAGLDYLD CLMRCMPCEF RPEYLVFLNV RCYKHEKLWE GIQSLGSLEE MDLSESENLT EIPDLSKATN LKHLYLNNCK SLVTLPSTIG NLQKLVRLEM KECTGLEVLP TDVNLSSLET LDLSGCSSLR TFPLISKSIK WLYLENTAIE EILDLSKATK LESLILNNCK SLVTLPSTIG NLQNLRRLYM KRCTGLEVLP TDVNLSSLGI LDLSGCSSLR TFPLISTNIV WLYLENTAIG EVPCCIEDFT RLRVLLMYCC QRLKNISPNI FRLRSLMFAD FTDCRGVIKA LSDATVVATM EDSVSCVPLS ENIEYTCERF WGELYGDGDW DLGTEYFSFR NCFKLDRDAR ELILRSCFKP VALPGGEIPK YFTYRAYGDS LTVTLPRSSL SQSFLRFKAC LVVDPLSEGK GFYRYLESEM TFNDVEFKFC CSNRIKECGV RLMYVSQETE YNQQTTRSKK RMRMTSGTSE EYINLAGDQI VADTGLAALN MELSLGEGEA SSSTSLEGEA LSVDYMITKE QDEDIPFLDP VSGN // ID F4KD49_ARATH Unreviewed; 812 AA. AC F4KD49; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 28-FEB-2018, entry version 50. DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:AED95220.1}; GN OrderedLocusNames=At5g45240 {ECO:0000313|Araport:AT5G45240, GN ECO:0000313|EMBL:AED95220.1}; GN ORFNames=K18C1.12 {ECO:0000313|EMBL:AED95220.1}, GN K18C1_12 {ECO:0000313|EMBL:AED95220.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AED95220.1, ECO:0000313|Proteomes:UP000006548}; RN [1] {ECO:0000313|EMBL:AED95220.1, ECO:0000313|Proteomes:UP000006548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RX PubMed=11130714; DOI=10.1038/35048507; RG Kazusa DNA Research Institute; RG Cold Spring Harbor and Washington University in St Louis Sequencing Consortium; RG European Union Arabidopsis Genome Sequencing Consortium; RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., RA Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., RA Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T., RA Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., RA Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., RA Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., RA Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., RA Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., RA Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., RA Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., RA Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., RA Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J., RA Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M., RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., RA Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T., RA Entian K.D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.A., RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., RA Mooijman P., Lankhorst R.K., Weitzenegger T., Bothe G., Rose M., RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., RA Mayer K., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.W., RA Bevan M., Fransz P.; RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis RT thaliana."; RL Nature 408:823-826(2000). RN [2] {ECO:0000313|EMBL:AED95220.1, ECO:0000313|Proteomes:UP000006548} RP GENOME REANNOTATION. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CP002688; AED95220.1; -; Genomic_DNA. DR RefSeq; NP_199337.2; NM_123892.2. DR UniGene; At.55386; -. DR ProteinModelPortal; F4KD49; -. DR SMR; F4KD49; -. DR PaxDb; F4KD49; -. DR EnsemblPlants; AT5G45240.1; AT5G45240.1; AT5G45240. DR GeneID; 834560; -. DR Gramene; AT5G45240.1; AT5G45240.1; AT5G45240. DR Araport; AT5G45240; -. DR TAIR; locus:2153338; AT5G45240. DR InParanoid; F4KD49; -. DR OrthoDB; EOG093615T4; -. DR Proteomes; UP000006548; Chromosome 5. DR ExpressionAtlas; F4KD49; baseline and differential. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006548}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000006548}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 36 123 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 812 AA; 93051 MW; 7DCF1F21A933400E CRC64; MDKKEETKQP DNIIYDKNDS SVASFISYLM AGFGCRGIKQ FLGIYLVILS RDYASSVLCL ENLELCCDDK KSYEVVPVFY GVSRSDVRQQ SGPFSDAFTK LERSNPADHV TKWRRMFAKI AELKGHEYDE ELSEESEFVE EIVEDVYELL NPTEEIRIHS RQLDIQNLLC KQQWGLRTLG ILGKPGIGKT TLARAVFRRM VGGYDASHFV KDFHTRYSEM TLEPLPAHFL CMTQVEEFDL NNSGSEQCHR QKRVLIVLDD VRNEQDAMSF LGEIDQFGPG SLIIITSRDR QVLEKCHLNE IYELNGLNGE DARKLFTRCA FGKDVIVKNL PMIVIKGFEG NPSALRSYAN KFKGKTTEDS MRILFKDAVF NTKKNTSMCI YSNIAIHEHK SIFLNKTVLH AIQNIIFDLE EHPDLDLPNH VAESISDLRS PCVHHPSVQV QSLPKHFHRR QLVLLHGLAC QFYKLWEGYK RFSRLRKINL GHCEKLVQVV ELSNACYLEE INLQDCKNLD TFPDTDQLEN LQFLDLSNCS GIKYFQENAS KLEKLWDGAQ STGFLIPERN PRSTNLERLD LSVCSSLMLL PPSIGHLQQL KDLNMEEISR NISYLYLDKT AIEEVPQWIE DISGLSDLSM SDSWQNHPEE ISTSLMRVDM SGNSFERLPD TWTSIQPKDL ILGNCKNLVS LPELPATLSL LTANNCVSLE SLYVHGNVLT VSLPRISLSK QILRYKACIV VESRPGPVND PPAELSYGDV QFEFLCLDHR KEIIKIKECG IQLMEVYSRK RSGTEDGNKP AENDEELRRI RKQMRVRMTK HW // ID F4WID8_ACREC Unreviewed; 1045 AA. AC F4WID8; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 28-FEB-2018, entry version 34. DE SubName: Full=Protein toll {ECO:0000313|EMBL:EGI66069.1}; GN ORFNames=G5I_05461 {ECO:0000313|EMBL:EGI66069.1}; OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex OS octospinosus echinatior). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata; OC Vespoidea; Formicidae; Myrmicinae; Acromyrmex. OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755}; RN [1] {ECO:0000313|Proteomes:UP000007755} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21719571; DOI=10.1101/gr.121392.111; RA Nygaard S., Zhang G., Schiott M., Li C., Wurm Y., Hu H., Zhou J., RA Ji L., Qiu F., Rasmussen M., Pan H., Hauser F., Krogh A., RA Grimmelikhuijzen C.J., Wang J., Boomsma J.J.; RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key RT adaptations to advanced social life and fungus farming."; RL Genome Res. 0:0-0(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; GL888175; EGI66069.1; -; Genomic_DNA. DR InParanoid; F4WID8; -. DR Proteomes; UP000007755; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 16. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007755}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00138699}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007755}; KW Repeat {ECO:0000256|SAAS:SAAS00490532}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 641 665 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 712 855 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1045 AA; 117040 MW; E95B86F2E77A9C2A CRC64; MFKDLFFLQI LDLRNNSIDR IESNAFLPLY NLHTLELSDN KLHTIGAQLF NGLFVLNRLT MSGNSISNID TMAFRNCSDL KELDLSGNEL TAVPDALRDL AFLKTLDLGE NRISEFHNGS FRNLHQLTGL RLIGNDIGNL THGMLWDLPN LQILNLARNK VQHVERHAFE RNIKLEAIRL DGNFLSEING VFTSITSLLL LNLSENHIEW FDYAFIPVNL KWLDIHGNFI ESLGNYYKIR NSKVKTLDAS HNRITELSPL SVPDSVELLF INNNYISTVR PNTFADKVNL TRVDMYANMI ETMELTSLLL TKVPENKPLP EFYIGGNPFN CNCSMDWLPA INNQTSTREY PRVMDLDNAM CRTSGPRGVA IVPASTARSE QFLCRYEAHC FALCHCCDFD ACDCEMTCPA GCKCYNDRTW NTNAVDCSSL GVEEIPRRIP MDATEVYLDG NVLRELQNHV FIGRKNMRVL YVNASGIESI QNRTFNGLNN LQILHLEDNR IRELKGFEFE RLSHLRELYL QNNMIGFIGN LTFLPLRSLE ILRLHGNRLV TFPVWQVTLN ARLVELSLGG NPWSCRCKFL QELSSWVSDN AHKVIDAGDV WCYYGGDARP SYRRRLNVNE TACSDYFAQG GVIESIMVSD YLPLVAATLS AIIVLLVIIV LAFVFREPVG AWAYSKYGLR FLRTKPGKAV TTASMGPAAA MAAGCCDADR DRLYDCYVCY SPNDEDFVLH SLAVELEHGA AGLRLCLHHR DLPCVLRASA PAPAVLEAVD ASRRVLIVLT RDFLQTEWSR FEFRAALHEA LRGRASQLIV IQAGNISIEV ERDPELRPYL RTAALILTWG EKRFWERLRY AIPSSTTTAI IATSTTTTTT AVGDVSVESK SSPLVYKRNI NTYTLDGGVG SLEKTGMSTL RGGQRAALFK DASSALMLQH APPAYSCGGA PLPPMLPQQQ QQPQLPPPSS SPAQPRLTVN HAYRDAMPAS NLITTTVATT NTANCGVGED HRRPLSEHIY SSIDSDYSTL ERTAWRQQQP PPPPPPPTSG QAYLV // ID F6NLN8_DANRE Unreviewed; 816 AA. AC F6NLN8; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 28-MAR-2018, entry version 55. DE SubName: Full=Toll-like receptor 4a, like {ECO:0000313|Ensembl:ENSDARP00000098602}; GN Name=tlr4al {ECO:0000313|Ensembl:ENSDARP00000098602, GN ECO:0000313|ZFIN:ZDB-GENE-090507-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000098602, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000098602} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000098602}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000098602, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000098602, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; BX908770; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001315534.1; NM_001328605.1. DR STRING; 7955.ENSDARP00000098602; -. DR PaxDb; F6NLN8; -. DR Ensembl; ENSDART00000113952; ENSDARP00000098602; ENSDARG00000075671. DR GeneID; 795671; -. DR KEGG; dre:795671; -. DR CTD; 795671; -. DR ZFIN; ZDB-GENE-090507-2; tlr4al. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; F6NLN8; -. DR KO; K10160; -. DR OMA; EDWVRNE; -. DR OrthoDB; EOG091G01RC; -. DR TreeFam; TF351113; -. DR Reactome; R-DRE-5686938; Regulation of TLR by endogenous ligand. DR Reactome; R-DRE-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. DR Reactome; R-DRE-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex. DR Proteomes; UP000000437; Chromosome 13. DR Bgee; ENSDARG00000075671; -. DR GO; GO:0005929; C:cilium; IBA:GO_Central. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:InterPro. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0003341; P:cilium movement; IBA:GO_Central. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0042116; P:macrophage activation; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR025875; Leu-rich_rpt_4. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF12799; LRR_4; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 816 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003343936. FT TRANSMEM 626 646 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 670 816 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 816 AA; 94281 MW; FAE2AE9DADD9B643 CRC64; MNFFTISAFI IYFPIGAGQS CTEIIENLHY SCMGRNLSYI PSRIPSSVQT LDFSFNDLKW LKKTVFPVFT FLRVLDLSRC HIRQIENDAF YNVKNLTTLF LTGNPIIYFA PGCLNTLYNL QRLVLVDIGL ESLQLNINNL TKLQELNVGT NYIQSMTLPP FMSTFKDFSL LDLHANNISI IRTNHTVVLR EIGKNMTLIL SRNPLLHIEP GSFKGVHLVE LDIRSTFVSF ASKKQGLNGL HGLNVTRLMF GMYKDDPKLY PSDLDYFDGL CSIHFYEAYY YMKERLDWKM NIFRCMINAT VVVVKGGVIR VIGYVPFHKI KELYLINTQL YTVPGKQLSH IRTLEKFVFT HNSATQVEKF LDMPKLQYVD LNSNQITLQS CCIDVLSGTP QIRYLNLSLN PQISLDKGGF EGLESLEILD FHHTKLLGIG SFTLLSNLKN LRYLDISYSS VTFVNVYCFY GLSSLKVLKM AGNSFQGDVA NYLFNNLTFL EHLDISYCHV IEIHLTSFKN LQRLRHLNLR GNNLMSIDFL TDPNLKQLTT FYVNKNSITT IPLDILQKLP MNLSEFDLSF NPIDCSCSQT DFMLWIINNQ RVLKQPENIL CKTISPNSDF RVTDFDIDHC VYKKKLIIAL LVFCVVFIVV LSILVYRFQF YLRYCWILLR GYRSPGQQEC SYDAFVIFSS YDEAWVMNEL MENLENGVPP IQLCLHMRDF QAGKSIASNI IDEGIMGSRK IIVVVSQHFI DSAWCRFEFE LAQSRFVVER NANIIIIILE DVAERKTKKV LGLHKHLKKN TYLKWSRDPL SNMRFWIRLR KAIVAT // ID F6QBE5_XENTR Unreviewed; 680 AA. AC F6QBE5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXETP00000059701}; GN Name=il1rapl2 {ECO:0000313|Ensembl:ENSXETP00000059701}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000059701, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000059701} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000059701} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAMC01035007; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035008; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035009; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035010; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035011; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035012; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035013; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035014; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035015; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01035016; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8364.ENSXETP00000059701; -. DR PaxDb; F6QBE5; -. DR Ensembl; ENSXETT00000062773; ENSXETP00000059701; ENSXETG00000033076. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F6QBE5; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Reactome; R-XTR-388844; Receptor-type tyrosine-protein phosphatases. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000033076; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 351 372 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 40 126 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 154 222 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 233 341 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 394 553 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 680 AA; 77767 MW; 86B656FA1381B9DC CRC64; MALLICSIVS ADVKLVSKRN SVDGCIDWSV DLKKYMGLAG EPVRVKCALF YSYIRTNYSM AQSAGLRLMW YKTKGDLEEP IIFSVVRMSK DDDSIWIHTA EVQDGGLYTC VLRNATYCMK VSMSLTVAEK EMGLCYNSTI RYLEKAEVTK KKQIICPDID DYRTLNEDIE VAWYKECKPK KWRSLIIQKG NSLLIQDVQK EDGGNYTCEL KYEGRLIRRT IQLKVTALFT TRPPKPLFPV ENQPSVIDVQ LGSPLSVFCR AFFGFSGESG PIIYWMRGEK FIEELENHIK EGVIRLLKEY LGEKEVELAL TFDAVQEADL GNYTCHVENR NGRKHASIIL RKKDLKYNIE LAGGLGAILL VFIVLVSVYK CYNIELMLFY RQNFGSDEAA EDNKEYDAYL SYTKVDPDSL DNESKEEEQF ALEILPDILE KHYGYKLFIP DRDMIPSPTY IEDLARCVEQ SRRLIIVLTP DYVIRRGWSI FVLDSRLQNM LTSGEIKVIF IECTNLRGKV NYEEVESLKH AIKQQSLIKW DGPKSSKMNS KFWKRLVYEM PAKKREVLSR QHVLDSGEQS LFGDLQTVPS IAVTGNSGTL APSQLDLSAF HHADSLQMRH FCRAYEYEKP TPPLPEATLG NHHTYCNIPL TLLNGQQTHN SAAKEQQGFH GNSTLIPLSS RELSFTSDIW // ID F6S8L8_CALJA Unreviewed; 1049 AA. AC F6S8L8; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 56. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSCJAP00000007128}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSCJAP00000007128}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000007128, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000007128, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000007128} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ACFV01089587; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACFV01089588; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACFV01089589; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002762664.1; XM_002762618.4. DR ProteinModelPortal; F6S8L8; -. DR STRING; 9483.ENSCJAP00000007128; -. DR Ensembl; ENSCJAT00000007528; ENSCJAP00000007128; ENSCJAG00000003924. DR GeneID; 100398462; -. DR KEGG; cjc:100398462; -. DR CTD; 51284; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; F6S8L8; -. DR KO; K05404; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000008225; Chromosome X. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 17. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 840 865 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 889 1036 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1049 AA; 120993 MW; 90F8E479AC34B30E CRC64; MVFPMWTLKR QFLILFNIIL ISKLLGARWF PKTLPCDVTL DVTENHVIVD CTDKHLTEIP GDIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC VPIRLGSKNN VCTRRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCN VSYSIEEDAF LNLTKLKVLS LRDNNVTTIP TVLPSTLTEL YLLNNMIAKI QEGDFNNLNQ LQILDLGGNC PRCYNAPYPC TPCENNSPLQ IPENAFDALT ELKVLRLRST SLQHVPARWF KNINNLQELD LSQNFLAKEI GDAKFLHFLP NLIQLDLSFN FELQVYRAFM NLSQAFSSLK SLKILRIRGY VFKELQSFNL LPLHNLQNLE VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART SVESSEPQVL EQLHYFKYDE YARSCRFKTK EASFVPINES CHQYEHTLDL SRNNIFFVKS SDFQHLSFLE CLNLSGNSIG QTLSGSEFQP LVELKYLDFS NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKALQK LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWRDGDN RYLQLFKNLL KLEELDISRN SLSFLPPGVF DGMPPNLKNL SLAKNGLKSF NWGKLQCLKN LDTLDLSHNQ LTTVPERLSN CSRSLKKLIL KNNQIRRLTK YFLQDAFQLR YLDLSSNKIQ MIQKTSFPEN VLNNLEMLLL HHNRFLCTCD AVWFVWWVNH TEVTIPYLAT DVTCVGPGAH KGQSVVSLDL YTCELDLTNL ILFSLSISAS LFLMVIMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDSC YDAFIVYDTK DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF LQLRKRLCGR SVLEWPTNPQ AHPYFWQCLK NALAADNHVA YSQVFKETV // ID F6THF1_HORSE Unreviewed; 390 AA. AC F6THF1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000013884}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013884, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000013884, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013884, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000013884} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013884}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6THF1; -. DR STRING; 9796.ENSECAP00000013884; -. DR PaxDb; F6THF1; -. DR Ensembl; ENSECAT00000017129; ENSECAP00000013884; ENSECAG00000016331. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F6THF1; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000002281; Chromosome X. DR Bgee; ENSECAG00000016331; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 390 AA; 45220 MW; 144F7682BA19E149 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDKHYYR SYEYDVPPTG TLPLTSIGNQ HTYCNIPMTL INGQRPQTKS SREQNPDEAH TNSAILPLLP RETSISSVIW // ID F6TZ42_MONDO Unreviewed; 666 AA. AC F6TZ42; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 28-MAR-2018, entry version 37. DE SubName: Full=Interleukin 1 receptor accessory protein like 2 {ECO:0000313|Ensembl:ENSMODP00000003919}; GN Name=IL1RAPL2 {ECO:0000313|Ensembl:ENSMODP00000003919}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000003919, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000003919, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000003919} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6TZ42; -. DR STRING; 13616.ENSMODP00000003919; -. DR Ensembl; ENSMODT00000004005; ENSMODP00000003919; ENSMODG00000003219. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F6TZ42; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000002280; Chromosome X. DR Bgee; ENSMODG00000003219; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 339 357 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 28 114 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 142 214 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 221 329 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 382 541 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 666 AA; 76564 MW; A79686B1B8B529FE CRC64; MSFTLLLFSV DGCIDWSVDL KTYMALAGEP VRVKCALFYS YIRTNYSTAQ SMGLRLIWYK NKGDLEEPII FSEVRMSKED DSIWFHSVEA QDSGFYTCVL RNSTYCMKVS MSLTVAENES GLCYNSQIRY SEKSEVTKRK EIVCPDMEDY KTANKEPDVV WYKECKPKMW RSIIIQKGNA LLIQEVHEED GGNYTCELKY EGKLIRRTTE LKVTALLTDK PPKPLFPREN QPSVIDVQLG KPLNIPCKAF FGFSGESGPM IYWMKGEKFI EELAGHIREG EIRLLKEHLG EKEVELSLTF DAVVEADLAN YTCHVENRNG RKYASILLRK KDLIYKIELA GGLGAILLLL VLLIIIYKCY NIELLLFYRQ NFGNNEDADD NKEYDAYLSY TKVDPDALDC DNNEEEQFAL EILPDVLEKH YGYKLFIPDR DLIPSGTYIE DLTRCIEQSR RLIIVLTPDY VLRRGWSIFE LETRLHSMLV SGEIKVIWIE CTELKEKVNC REVEVLKRNI KLLSLVKWKG TQSSKLNSKF WKHLVYEMPM KKKVTLSRRQ VLDSAEQGLF GELQTVPSIA VTSTSAALVS SQADLSDFHP TDSMPMRHCC RSYNYEMPTS SLPLGTHHHT YCNIPLTLLN GQLPLNNASK NTPEFHRSSP LQPLSSKELS FTSDIW // ID F6U7W1_CHICK Unreviewed; 924 AA. AC F6U7W1; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGALP00000013260}; GN Name=TLR15 {ECO:0000313|Ensembl:ENSGALP00000013260}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000013260, ECO:0000313|Proteomes:UP000000539}; RN [1] {ECO:0000313|Ensembl:ENSGALP00000013260, ECO:0000313|Proteomes:UP000000539} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000013260, RC ECO:0000313|Proteomes:UP000000539}; RX PubMed=15592404; DOI=10.1038/nature03154; RG International Chicken Genome Sequencing Consortium; RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., RA Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., RA Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., RA Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C., RA Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., RA Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., RA Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., RA Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., RA Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., RA Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., RA van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., RA Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., RA Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., RA Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., RA Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., RA Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., RA Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., RA Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., RA King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., RA Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., RA Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., RA Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., RA Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., RA Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., RA Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., RA Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., RA Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., RA Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., RA Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., RA Mardis E.R., Wilson R.K.; RT "Sequence and comparative analysis of the chicken genome provide RT unique perspectives on vertebrate evolution."; RL Nature 432:695-716(2004). RN [2] {ECO:0000313|Ensembl:ENSGALP00000013260} RP IDENTIFICATION. RC STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000013260}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AADN04000266; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9031.ENSGALP00000013260; -. DR PaxDb; F6U7W1; -. DR Ensembl; ENSGALT00000013275; ENSGALP00000013260; ENSGALG00000008166. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR OMA; CDLYWFV; -. DR OrthoDB; EOG091G05L8; -. DR Proteomes; UP000000539; Chromosome 3. DR Bgee; ENSGALG00000008166; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000539}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000539}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 59 80 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 709 732 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 761 905 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 924 AA; 104188 MW; C74F4900EC939538 CRC64; MVPIGRKVSC CKKENPATHP HSPSCPAAST TKAAAWPGSF RGCSRAARRV GTGNRRMRIL IGSLYFYFIS FLFSKVNGFL TQRTSPVSSF PFYNYSYLNL SSVSQAQAPK TARALNFSYN AIEKITKRDF EGFHVLEVLD LSHNHIKDIE PGAFENLLSL VSVDLSFNDK NLLVSGLAPH LKLIPTSGAS GPSQIYMYFQ KSAEAALEPS APAELLPHLE DPPNPGNVNP RFRQRRTEEN KTSPPAATLR PDLCGAPING LLDLSRTKLS NEELTAKLDA DLCQAQLGTV LEFNISHSDL EMDLLSLFIL FLPMKDIQSV DASYNRITIN NIDVEAICHF PFSNFSFLNI SNNPINSLET VCLPESITVI DLSFTNISTI PANFAKKLSK LERMYVQGNQ LIYTVRPENP SATPRPPPGT VQISAISLVR NQAGTPIESL PESVKHLKVS NCSIVELPEW FANRMQELLF LDLSSNRISM LPDLPISLQQ LDISNSDIKI IPPRFKSLSN LTVFNIQNNK LTEMHPEYFP STLTTCDISK NKLKVLSLTK ALENLESLNV SGNLITRLEP ACQLPSLTNL DSSHNLISEL PDHLGQSLLM LKHFNLSGNK ISFLQRGSLP ASLEELDISD NAITTIVQDT FGQLTSLSVL TVQGKHFFCN CDLYWFVNIY IRNPHLQING KDDLRCSFPP DRRGSLVKSS NLTLLHCSLG IQMAITACMA ILVVLVLTGL CWRFDGLWYV RMGWYWCMAK RRQYKKRPEN KPFDAFISYS EHDADWTKEH LLKKLETDGF KICYHERDFK PGHPVLGNIF YCIENSHKVL FVLSPSFVNS CWCQYELYFA EHRVLDENQD SLIMVVLEDL PPDSVPQKFS KLRKLLKRKT YLKWSPEEHK QKIFWHQLAA VLKTTNEPLV RAENGPNEDV IEME // ID F6U8S1_XENTR Unreviewed; 1042 AA. AC F6U8S1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 55. DE SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSXETP00000062585}; GN Name=tlr8 {ECO:0000313|Ensembl:ENSXETP00000062585}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000062585, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000062585} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000062585}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000062585} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAMC01026723; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F6U8S1; -. DR STRING; 8364.ENSXETP00000062585; -. DR PaxDb; F6U8S1; -. DR Ensembl; ENSXETT00000063320; ENSXETP00000062585; ENSXETG00000030579. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; F6U8S1; -. DR OMA; WPDNPKA; -. DR OrthoDB; EOG091G014D; -. DR TreeFam; TF351113; -. DR Reactome; R-XTR-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-XTR-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-XTR-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-XTR-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-XTR-975155; MyD88 dependent cascade initiated on endosome. DR Proteomes; UP000008143; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro. DR GO; GO:0004872; F:receptor activity; IBA:GO_Central. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:InterPro. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13516; LRR_6; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 21. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1042 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003343849. FT TRANSMEM 832 855 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 880 1027 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1042 AA; 119940 MW; 39A3E7C4215B61BB CRC64; IESIFSNSIL KTALLVVVTT CNSLAYSDMT PNNRTIPCRI TENGFFVSFD CSARRLKMVP HPITYNSDSA ELLLSQNLIL TINNESFYSW HNLTKIDLNW NHYPKSRLNN TDLCKRGLEI GNETFSYLTK LEELFIDHNF LCKIPQGIPS TVQTLSLSYN NIFSVKKQIL SPLINLKKLF LNHNCYFGNE CDHVVDIEEG TFAGLTELTV LDLSFNNMTR VPAKLPASLK ELYLSNNNIQ IIHSDDLQNL VNLEVLFLNG NCPRCFNANY PCKNLCKQIS ITIDPLAFQN LKNLTELHLG STSLRTIPPI WFQNTTQLKI LNLQLNYLVN EIASADFLLN LPFLEVLDLS FNYDLRSYAN NINISNHFSK LISLQELHIQ GYVFKHIAAK NLSPLINLPK LATINLGINF IKQVDFEVFQ NISGLKLIYL SENRITPFSE TNKQLFGVCK DQSYRISSPG VTFPTQSNFQ MTKIFSHLVK PQCSSRGKTL DLSLNSIFFI DPEEFRSFSD VSCLNLSFNS IGQDLNGTEF IYLKNLTYLD LSFNKLDFDS INAFQELPSL EVLDLSYNSH YFIVDGVTHR LKFIENLQYL KVLNLSWNKI STLTDFRLTS HSLKELQFSG NRLDVLWKNE DKRYQELFKN LYNLTCLDIS YNRLNKMTEV ELSNLPLSLT ELYLNNNKLD YFGWKALKAY KNLKHLDLSH NKLTMIMGNL SIHTYSLSSL IISYNSISSL PVAFLHKSRN LSELDLSFNH LKSINSSVFL SGSENYLTVL GLKGNPFVCT CEITDFISWI YANNVTIPRL ATDVNCAAPE NKKGSGIIFF DVHTCDLDGA AMILYFFSVF LVMSITVLPI LINVFSWDLW YVYHLCVAKL RLHKVCKSKC LYDVFITYDN KDPNVSDWIF NELCQHLEDK GDKHMYLCLE ERDWEPGKAI IDNLAHSINQ SNKTLFVLTK KYVKSGKFKT AFYLALQKLM DENMDVIVIV LLEPVLQNSQ YLRLRRKICK SSIMEWPKNP NTKSFFWQRM KNVLLTDNCN RYNNFYTDTI AN // ID F6WTG7_MONDO Unreviewed; 690 AA. AC F6WTG7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMODP00000008932}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSMODP00000008932}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000008932, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000008932, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000008932} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 13616.ENSMODP00000008932; -. DR Ensembl; ENSMODT00000009107; ENSMODP00000008932; ENSMODG00000007199. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F6WTG7; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000002280; Chromosome 4. DR Bgee; ENSMODG00000007199; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 354 375 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 128 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 156 212 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 236 344 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 397 556 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 690 AA; 79538 MW; C3A025815486F11F CRC64; PHLILIYETY TQSRKTVIRG VADGCTDWSV DIKKYQVLVG EPVRIKCALF YGYIRANYSL AQSAGLSLMW YKSSGPGDFE EPIAFDGTRM SKEEDSIWFR PTLVQDSGLY ACVIRNSTYC MKVSISLTVG ENDTGLCYNS KMKYFEKAEL SKSKEISCRD IEDFLTPYKE PEILWYKECR TKTWRPSIIF KRNILLIREV REDDIGNYTC ELKYGGFVVR RTTLFKILAP LTDKPPKLLY PLESKLTIQE TQLGNLANLT CRAFFGYSGD VSPLIYWMKG EKFIEDLDEN RVWESDIRIL KEHLGEQEVS ISLIVDSVEE GDLGNYSCYV ENGNGRRHAS VLLHKRELMY TVELAGGLGA ILLLLVCLVT IYKCYKIDIM LFYRNHFGAE EIDGDNKDYD AYLSYTKVDP DQWNQETGEE ERFALEILPD MLEKHYGYKL FIPDRDLIPT GTYIEDVARC VDQSKRLIIV MTPNYVVRRG WSIFELETRL RNMLVTGEIK VILIECSELR GIMNYQEVEA LKHTIKLLTV IKWHGPKCNK LNSKFWKRLQ YEMPFKRIEP ITHEQVLDVS EQGPFGELQT VSAISMAAAT STALATAHPD LRSTFHNTYH SQMRQKHYYR SYEYDVPPTG TLPLTSIGNQ HTYCNIPMTL INGQRPQTKS SREQNPDEAH TNSAILPLLP RETSISSVIW // ID F6XB14_HORSE Unreviewed; 565 AA. AC F6XB14; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSECAP00000007310}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSECAP00000007310, GN ECO:0000313|VGNC:VGNC:19011}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007310, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000007310, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007310, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000007310} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007310}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F6XB14; -. DR STRING; 9796.ENSECAP00000007310; -. DR PaxDb; F6XB14; -. DR Ensembl; ENSECAT00000009580; ENSECAP00000007310; ENSECAG00000009248. DR VGNC; VGNC:19011; IL1RL1. DR eggNOG; ENOG410IPTT; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F6XB14; -. DR OMA; VQGTIKW; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000002281; Chromosome 15. DR Bgee; ENSECAG00000009248; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0002113; F:interleukin-33 binding; IEA:Ensembl. DR GO; GO:0002114; F:interleukin-33 receptor activity; IEA:Ensembl. DR GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IEA:Ensembl. DR GO; GO:0090197; P:positive regulation of chemokine secretion; IEA:Ensembl. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 565 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003345196. FT TRANSMEM 335 366 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 33 108 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 119 202 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 217 308 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 380 543 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 565 AA; 64546 MW; D24D71CB7F10BC39 CRC64; TDKLRMRQWV LAVLTFLISS TAAKFLKSSW GLENEALIVR CPRQGKSRYP VDWYYSETNT NILTEKRNHL LASGESLKFL PANVNDSGIY TCILRSPAAN KTGYVNVTIY KKQPDCNIPD YLIYSKTSGS EKNSRIYCPT IDLYNWTAPV EWFKNCKVLQ GSRYHTHSTF LLIDNATSKD AGDYTCKFMH NENGVSYSVT ATRSFEVNDE EGFSLFPVII APPQNETKEV EIGKTASITC SACFGKGSQI MAAILWQVNR TKVGDFGEAR IQEKQEQNQS SSNEMTCLNA VLRIADVKEE DLSLKYECWA LNLHGSRNHI IRLRRKNPTE HQSTYYILAG FSILLMLIIV MMIMLKVFWI EVILLWRDIA RPYKTRNDGK IYDAYVIYPR NQKNSPEGAS SVEHFVHQIL PDVLENKCGY NLCIYGRDLR PGEDAVTAVE TNIQKSRRHI FILTPQITHS KEFAYEQEIA LHSALIQNDS KVILIEMEAL SKPGGLQFGE LQDSLKHLVK VQGTIKWREG HVDNKRSLNS KFWKHVRYHM PVPNKPPRKT SRLASLSAHG QECLL // ID F7C3S5_ORNAN Unreviewed; 667 AA. AC F7C3S5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSOANP00000010794}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSOANP00000010794}; OS Ornithorhynchus anatinus (Duckbill platypus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus. OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000010794, ECO:0000313|Proteomes:UP000002279}; RN [1] {ECO:0000313|Ensembl:ENSOANP00000010794} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000010794}; RX PubMed=8919867; DOI=10.1007/BF02198841; RA Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.; RT "The mitochondrial genome of a monotreme--the platypus RT (Ornithorhynchus anatinus)."; RL J. Mol. Evol. 42:153-159(1996). RN [2] {ECO:0000313|Proteomes:UP000002279} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279}; RX PubMed=18464734; DOI=10.1038/nature06936; RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., RA Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., RA Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., RA Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J., RA Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., RA Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., RA Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., RA Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., RA Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., RA Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., RA Churakov G., Kriegs J.O., Brosius J., Murchison E.P., RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., RA Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., RA Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., RA Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., RA Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., RA Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., RA Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., RA Wilson R.K.; RT "Genome analysis of the platypus reveals unique signatures of RT evolution."; RL Nature 453:175-183(2008). RN [3] {ECO:0000313|Ensembl:ENSOANP00000010794} RP IDENTIFICATION. RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000010794}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; F7C3S5; -. DR STRING; 9258.ENSOANP00000010794; -. DR Ensembl; ENSOANT00000010796; ENSOANP00000010794; ENSOANG00000006764. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F7C3S5; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000002279; Unplaced. DR Bgee; ENSOANG00000006764; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002279}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002279}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 334 355 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 20 108 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 136 206 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 216 324 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 377 536 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 667 AA; 76408 MW; F6012DA541E03527 CRC64; AADGCTDWSV DIKKYQVLVG EPVRIKCALF YGYIRANYSL AQSAGLSLMW YKSSGPGDFE EPIAFDGTRM SKEEDSIWFR PTLVQDSGLY ACVIRNSTYC MKVSISLTVG ENDTGLCYNS KMKYFEKAEL SKSKEISCRD VEDFFMPSRE PEILWYKECQ ARPWRPSIVF KRNVLLIREV REDDIGNYTC ELKSGGFVVR RTTHLTVTAP LTDRPPKLLH PLESKLTVQE IQLGNSANLT CRAFFGYSGE VSPLIYWMKG EKFIEDLDEN RVWESDIRVL KEHLGEQEVS ISLIVDSVEE GDLGNYSCYV ENGNGRRQAS VLLHKRELMY TVELAGGLGA ILLLLICLVT VYKCYKIEIM LFYRNHFGAE ELDAENKDYD AYLSYTKVDP DQWNQETGEE ERFALEVLPD MLEKHYGYKL FIPDRDLIPT GTYIEDVARC VDQSKRLIIV LTPSYVVRRG WSLFELETRL RTMLVTGEIK VILIECSRLS GLVNYQEVEA LKHTIKLLTV VKWRGPRSNR LNSRFWKRLR YEMPFKRAEP ARHEPVLDAS ERGPFGELQT VSAISMAAAT STALAPAHPD LRPPFPNTYH PQMRQKHYYT TWPRAGPWAL PLPAVAHQHT YCNIPMTLLN GQRAQTKPAR DQTPDEATRT AVLPLLPRET SVSSVNW // ID F7CJ16_HORSE Unreviewed; 1049 AA. AC F7CJ16; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 53. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000005855}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSECAP00000005855}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005855, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000005855, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005855, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000005855} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005855}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 9796.ENSECAP00000005855; -. DR PaxDb; F7CJ16; -. DR Ensembl; ENSECAT00000007908; ENSECAP00000005855; ENSECAG00000007883. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; F7CJ16; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000002281; Chromosome X. DR Bgee; ENSECAG00000007883; -. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1049 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003349416. FT DOMAIN 889 1036 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1049 AA; 121429 MW; A12C1529B4157889 CRC64; MFPMWTLKRE FLILFNMILI SKLLGARWFP KTLPCDVFLD APKAQVIVDC TDKHLTDIPG GIPTNATNLT LTINHIPGIS PASFHQLENL VEIDFRCNCV PVRLGPKDNV CKNRLQIKPR SFSRLTNLKS LYLDGNQLLE IPQDLPPSLQ LLSLEANNIF LIMKKNLTEL ANIEMLYLGQ NCYYRNPCNV SFFIEKDAFL NLKNLKLLSL KDNNITAVPT ILPSSLTELY LYNNIIAKIQ EDDFKMLNQL QILDLSGNCP RCYNVPYPCT PCENNSPLQI HANAFDALTE LQVLRLHSNS LQYVPQRWFK NINKLKELDL SQNFLAKEIG DAKFLHLLHN LVQLDLSFNY ELQVYHASMN LSEAFSSLKN LRVLRIKGYV FKELKDLNLS PLRNLSNLEV LDLGTNFIKI ADLSIFKQFK TLKVIDLSMN KISPSGESSE VGFCSNTRTS VAGHGPQVLE TLHYFRYDEY ARSCRFKNRE TSSFLPFNEG CYMYGQTLDL SKNNIFFIKS SDFRHLSFLK CLNLSGNSIS QTLNGSEFQP LVELKYLDFS NNRLDLLYST AFEELRNLEV LDISSNSHYF QSEGITHMLN FTKNLKVLRK LMMNNNDIST STSRTMESES LTILEFRGNH LDVLWKDGDN RYLKFFKNLL NLKELDISEN SLSFLPPGVF ESMPPNLKTL YLVNNKFKSF NWGKLQLLKN LETLDLSYNQ LRTVPERLSN CSRSLKKLIL KNNQIRRLTK YFLQDAFQLR YLDLSSNKIQ IIQKSSFPEN VLNNLDMLLL HRNRFLCTCD AVWFVWWVNH TEVTIPYLAT DVTCTGPGAH KGQSVVSLDL YTCELDLTNL ILFSLSMSMA LFLMVVTTAN HLYFWDVWYS YHFCKAKIKG YQRLTLTDSC YDAFIVYDTK DPAVTEWVLD ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS KKTVFVMTDK YAKTENFKIA FYLSHQRLID EKVDVIILIF LEKPLQKSKF LQLRKRLCGS SVLEWPRNPQ AHPYFWQCLK NALATDNHVT YSQVFKETV // ID F7CXD6_XENTR Unreviewed; 475 AA. AC F7CXD6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSXETP00000063019}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000063019, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000063019} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000063019}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., RA Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., RA Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T., RA Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., RA Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., RA Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., RA Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., RA Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., RA Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000063019} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAMC01034815; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAMC01034816; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8364.ENSXETP00000063019; -. DR PaxDb; F7CXD6; -. DR Ensembl; ENSXETT00000061216; ENSXETP00000063019; ENSXETG00000031567. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F7CXD6; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000031567; -. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008143}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}. FT DOMAIN 73 148 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 160 261 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 315 475 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 475 AA; 54967 MW; 9F7468DE438D0222 CRC64; IQWYLEKGFG DLDEIGMSNY ENITKKGNTL LFSSAEIQNS GMYICNYYRV ENVCLRIILD VRTKDICLPY EPSISCPSQH CHHGLNKSKV KWYKDGKEII ERITRRSLKL TGDAIVFTQT YEPDGGLYTC DYSLYINESQ WTVRATIDVE VGAKETEKKP EILHPKDGEH IEAELGKPLK LHCRVVFGFE RYLNPVINWI KKTTDCRLGI ERVPKQHVTG VGTTYILTST LQKVSVDDFN STFLCHVRNS KGNATSVIKL IRKQTDCILL ALHVRKLPAL INTLYKKVFF HKEWLKLHKC NNTHKQYDMF IKDDKDFDAF VSYAKHNSDF HEETFEDSHD EEVFATQFLP SVLEDKYHFK LCLLERDILP GGAYVEDVVK IIKRSRRLIA ILSQRYITSP SVFELQAAIT CTLEEEPIKL ILIQLSPFKE PKSLPHIVKK ALNALPTVEW KGNSDYSPSI DTKFWNKVRY QMPVK // ID F7EHK1_MONDO Unreviewed; 569 AA. AC F7EHK1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSMODP00000002923}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSMODP00000002923}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000002923, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000002923, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000002923} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 13616.ENSMODP00000002923; -. DR Ensembl; ENSMODT00000002981; ENSMODP00000002923; ENSMODG00000002401. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F7EHK1; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000002280; Chromosome 7. DR Bgee; ENSMODG00000002401; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 569 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003357210. FT TRANSMEM 350 376 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 27 128 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 245 340 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 397 552 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 569 AA; 65601 MW; C8AC6BB1169CEC64 CRC64; MFSLHHIFLW LVIRAGVKGD SELSGCPTKS SWRYLARSGE KFFLFCDVPR RGRISKKDIC GKTRCHDISC SSDVRWYKHP QNGSQPYAIL NEHSHITWEN HLLQFSPVGI NDAGFYICTF KYEPKGITCF LNITLEVQPK EKTPCLDSVK NELFLLIGST DRVPCPGINC ERDIQSEVTW YKNGTLCPRW TSTHIEFTEI FYRDRGVYVC DYKKSINSTW WIVRAVVDVI AVVKNTSSKP TILYPTVDML TLEVELGKPL TLDCKAQFEF ERNFNPVIKW FVDDPGLNRK ELREGNKSIE NDVEQKTIHF IAHLKEVTKK DLRRNFICFA QNSVGNTTLT IKLKQKKGVL FTYILFGTTI TLVAILMTSA LTYRYWIEIV LLYRTYQAKD ETLGDKKEFD AFVSYARDSF GDLDSSSLNE ESFALDLLPQ VLENKYGYTL CLFERDVIPG GAYTEDIVKI IKQSRRVICV LSSSYVNNPS VFELQAAVNL ALEDQTLKLI LIKFSPFKEP DSLPQRVRKA LSVLPTITWK NSKSAPPNSR FWSRIRYHMP VKNCRKLGSQ GFHFFPRIF // ID F7G3P2_MACMU Unreviewed; 696 AA. AC F7G3P2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 55. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:AFE64417.1, ECO:0000313|Ensembl:ENSMMUP00000002234}; GN Name=IL1RAPL1 {ECO:0000313|EMBL:AFE64417.1, GN ECO:0000313|Ensembl:ENSMMUP00000002234}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002234, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000002234, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002234, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002234} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002234}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|EMBL:AFE64417.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Caudate {ECO:0000313|EMBL:AFE64417.1}; RX PubMed=25319552; DOI=10.1186/1745-6150-9-20; RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., RA Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., RA Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S., RA Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.; RT "A new rhesus macaque assembly and annotation for next-generation RT sequencing analyses."; RL Biol. Direct 9:20-20(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JSUE03045159; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045160; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045161; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045162; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045163; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045164; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045165; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045166; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045167; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03045168; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JU320661; AFE64417.1; -; mRNA. DR RefSeq; XP_014982609.1; XM_015127123.1. DR UniGene; Mmu.25040; -. DR STRING; 9544.ENSMMUP00000002234; -. DR Ensembl; ENSMMUT00000002363; ENSMMUP00000002234; ENSMMUG00000001663. DR GeneID; 706588; -. DR KEGG; mcc:706588; -. DR CTD; 11141; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR KO; K05170; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000006718; Chromosome X. DR Bgee; ENSMMUG00000001663; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:AFE64417.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 696 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014090947. FT TRANSMEM 360 381 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 6 134 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 162 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 350 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 403 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 696 AA; 79953 MW; 324042B5FCF71A05 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSIDIKK YQVLVGEPVR IKCALFYGYI RANYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFIVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG DSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LVCLVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSSREQ NPDEAHTNSA ILPLLPRETS ISSVIW // ID F7H1X0_MACMU Unreviewed; 686 AA. AC F7H1X0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 56. DE SubName: Full=Interleukin 1 receptor accessory protein like 2 {ECO:0000313|Ensembl:ENSMMUP00000008788}; DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:EHH30964.1}; GN Name=IL1RAPL2 {ECO:0000313|Ensembl:ENSMMUP00000008788}; GN ORFNames=EGK_20787 {ECO:0000313|EMBL:EHH30964.1}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000008788, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000008788, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008788, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|EMBL:EHH30964.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH30964.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). RN [3] {ECO:0000313|Ensembl:ENSMMUP00000008788} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008788}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JSUE03046403; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046404; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046405; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046406; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046407; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046408; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046409; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046410; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046411; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03046412; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CM001273; EHH30964.1; -; Genomic_DNA. DR STRING; 9544.ENSMMUP00000008788; -. DR Ensembl; ENSMMUT00000009353; ENSMMUP00000008788; ENSMMUG00000006683. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000006718; Chromosome X. DR Bgee; ENSMMUG00000006683; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004910; F:interleukin-1, Type II, blocking receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004077; IL-1_rcpt_II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01539; INTRLEUKN1R2. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EHH30964.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 686 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014091113. FT TRANSMEM 357 378 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 132 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 160 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 239 347 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 400 559 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 686 AA; 78757 MW; 07E285F2D26A829D CRC64; MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SNQEPDVVWY KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG LGAIFLLLVL LVVVYKCYNI ELMLFYRQHF GADETNDDNK EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL IPSGTYIEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGPK SSKLNSKFWK HLVYEMPIKK KEMLSRCQVL DSAEQGLFGE LQPIPSIAMT TTSATLVSSQ ADLPEFHHSD SMQMRHCCRG YKHEIPTTTL PVPSLGNHHT YCNLPLTLLN GQLPLNNTLK DTQEFHRNNS LLPLSSKELS FTSDIW // ID F7HHC1_MACMU Unreviewed; 456 AA. AC F7HHC1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 28-MAR-2018, entry version 49. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSMMUP00000036207}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSMMUP00000036207}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036207, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000036207, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036207, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000036207} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036207}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JSUE03011630; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000036207; -. DR Ensembl; ENSMMUT00000043196; ENSMMUP00000036207; ENSMMUG00000009246. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F7HHC1; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000006718; Chromosome 13. DR Bgee; ENSMMUG00000009246; -. DR ExpressionAtlas; F7HHC1; baseline. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 217 240 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 7 93 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 109 211 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 264 420 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 456 AA; 51665 MW; DCC17757A26FDAC7 CRC64; MILEVKPQSN ASCENSASHK QDLLLGSTGS ISCPSLSCQS DAQSPEVTWY KNGKLLSMTR SNRIVVDEVY IYHQGTYVCD YTQSDTASSW TVRAVVQVRT IVGDTKLKPD ILDPVESTLE VELGKPLTIS CKARFGFERV FNPVMKWYIK DADLEWEVSV PEAKSIKSTL KDEIIERNII LEKVTQRDLR RTFVCFVQNS IGNTTQSVQL KEKRGVVLLY ILLGTIGTLV AVLVASALLY RHWIEIVLLY RTYQSKDETL GDKKDFDAFV SYAKWSSFPS EATSSLTEEH LALSLFPDVL ENKYGYTLCL LERDVAPGGV YAEDIVSVIK RSRRGIFILS PNYVNGPSIF ELQAAVNLAL DDQTLKLILI KFCYFQEPES LPHLVKKALR VLPTVTWRGL KSVPPNSRFW TKMRYHMPVK NSQGFTWSQL RITSRIFQWK GLSTTETTGR SSQPKE // ID F7IJ18_CALJA Unreviewed; 437 AA. AC F7IJ18; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSCJAP00000014102}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSCJAP00000014102}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000014102, ECO:0000313|Proteomes:UP000008225}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000014102, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000014102} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ACFV01076484; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACFV01076485; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACFV01076486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACFV01076487; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7IJ18; -. DR STRING; 9483.ENSCJAP00000014102; -. DR Ensembl; ENSCJAT00000014858; ENSCJAP00000014102; ENSCJAG00000007604. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; F7IJ18; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000008225; Chromosome X. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50249 MW; FEC52E742A9BC580 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID F8W5D6_DANRE Unreviewed; 746 AA. AC F8W5D6; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 28-MAR-2018, entry version 52. DE SubName: Full=Toll-like receptor 4a, like {ECO:0000313|Ensembl:ENSDARP00000123702}; GN Name=tlr4al {ECO:0000313|Ensembl:ENSDARP00000123702, GN ECO:0000313|ZFIN:ZDB-GENE-090507-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000123702, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000123702} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123702}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000123702, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123702, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; BX908770; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSDART00000148623; ENSDARP00000123702; ENSDARG00000075671. DR ZFIN; ZDB-GENE-090507-2; tlr4al. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR Reactome; R-DRE-5686938; Regulation of TLR by endogenous ligand. DR Reactome; R-DRE-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. DR Reactome; R-DRE-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex. DR Proteomes; UP000000437; Chromosome 13. DR Bgee; ENSDARG00000075671; -. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:InterPro. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0042116; P:macrophage activation; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR025875; Leu-rich_rpt_4. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF12799; LRR_4; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 9. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 556 576 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 600 746 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 746 AA; 86381 MW; E5CA69C152289831 CRC64; KYIFFLNFRC HIRQIENDAF YNVKNLTTLF LTGNPIIYFA PGCLNTLYNL QRLVLVDIGL ESLQLNINNL TKLQELNVGT NYIQSMTLPP FMSTFKDFSL LDLHANNISI IRTNHTVVLR EIGKNMTLIL SRNPLLHIEP GSFKGVHLVE LDIRSTFVSF ASKKQGLNGL HGLNVTRLMF GMYKDDPKLY PSDLDYFDGL CSIHFYEAYY YMKERLDWKM NIFRCMINAT VVVVKGGVIR VIGYVPFHKI KELYLINTQL YTVPGKQLSH IRTLEKFVFT HNSATQVEKF LDMPKLQYVD LNSNQITLQS CCIDVLSGTP QIRYLNLSLN PQISLDKGGF EGLESLEILD FHHTKLLGIG SFTLLSNLKN LRYLDISYSS VTFVNVYCFY GLSSLKVLKM AGNSFQGDVA NYLFNNLTFL EHLDISYCHV IEIHLTSFKN LQRLRHLNLR GNNLMSIDFL TDPNLKQLTT FYVNKNSITT IPLDILQKLP MNLSEFDLSF NPIDCSCSQT DFMLWIINNQ RVLKQPENIL CKTISPNSDF RVTDFDIDHC VYKKKLIIAL LVFCVVFIVV LSILVYRFQF YLRYCWILLR GYRSPGQQEC SYDAFVIFSS YDEAWVMNEL MENLENGVPP IQLCLHMRDF QAGKSIASNI IDEGIMGSRK IIVVVSQHFI DSAWCRFEFE LAQSRFVVER NANIIIIILE DVAERKTKKV LGLHKHLKKN TYLKWSRDPL SNMRFWIRLR KAIVAT // ID G1K9P0_ANOCA Unreviewed; 1056 AA. AC G1K9P0; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 28-MAR-2018, entry version 60. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSACAP00000001544}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSACAP00000001544}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001544, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000001544, ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000001544}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSACAP00000001544} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR RefSeq; XP_003218898.2; XM_003218850.3. DR ProteinModelPortal; G1K9P0; -. DR STRING; 28377.ENSACAP00000001544; -. DR Ensembl; ENSACAT00000001581; ENSACAP00000001544; ENSACAG00000001655. DR GeneID; 100563333; -. DR KEGG; acs:100563333; -. DR CTD; 51284; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G1K9P0; -. DR KO; K05404; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000001646; Chromosome 3. DR Bgee; ENSACAG00000001655; -. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 16 39 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 848 872 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 896 1043 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1056 AA; 122185 MW; F969C37DDBBFEE7A CRC64; MSKMAIYPWY IISRRVLFMI QLVFFMTSLL PMMIPAIWYP KTLPCIVTNT TKGYVTVDCS EQHLRVFPDG IPSEVTNLSL TINDIHNIDP SNFEKFKNLL EIDFRCNCLP PKLGPQDHVC NTKLKIETHS FANLFQLKSL YLDGNQLSAI PRGLPPNLLL LSLEVNNIFS IHEDDFIELG KLESLFLGKN CYYRNACNTS FFINETAFRN LKALRLLSLK ANNISTVPKN LPSTLTELSL YNNAIRNISE HDLSGLHNLE TLDLSGNCPR CHNAPYNCTE CPKNTSIEIH PNAFDSLKQL RILRLHSTSL RAVKSQWFYH TKKLEVLDLS QNYLANEIEK ADFLNYLPNL INLDLSFNFD LGAYRSHLSL SKTFSNLTNL QTLRLRGFVF KELDGSTINN LISLKNLRVL DFGTNFIRNV DLTLFNKLPA LNVINLSFNK ISLFSNDANG RCYSGPEPSP DRNDRFLLQD MHYFMYDEYS RSCKSKNKEV TYSFPFTTEA ACRNYGKTLD LSRNNIFFIT ASDFQQLTYL KCLNLSSNAM SQTLNGTEFK YLPRLKYLDF SDNRVDLLYP NAFEGLRELE VLNLSDNSHY FKAEGITHML GFTSNLTSLT TLIMNGNEIS TSTEKGMASN SLKTLEFKRN HLDVLWKDDY YSFFKNLTNL ENLDISENSL TFLRPDVFDG LPSSLRELRL ASNKMKYFRW DKLQVLEKLE VLDLSNNQLT TVPYELSNCS KTLKKLILQN NNIKRLTDNF LQNAVTLKYL DLSFNKIKTL RNSSFPKDVI NNLETLLLHG NPFKCNCDLV WFVWWVNQTS VTIPFLATDV TCTGPGTWRG KSVVYLDLET CELDFSQILY LSSVSAIMFV MIITTISQLY FWDMWYLYHF FAASLKGYKR LFSSDIVYDA FIAYDKRDAA VSEWVLKELV EKLEDEREKQ FNLCLEERDW LPGEPVLTNL SESIQVSRKT VFVLTNKYIA SGNFRMAFYL AHQRLMDEKV DVIILIFLEK VLQMSKCLRL RKILCSQSVL EWPTNPRSQC YFWHCLRNSL TANHDTSYSK LFKEMV // ID G1LR75_AILME Unreviewed; 1175 AA. AC G1LR75; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 49. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000009559}; GN Name=TWF2 {ECO:0000313|Ensembl:ENSAMEP00000009559}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009559, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000009559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000009559} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ACTA01018545; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9646.ENSAMEP00000009559; -. DR Ensembl; ENSAMET00000009973; ENSAMEP00000009559; ENSAMEG00000009061. DR eggNOG; KOG1747; Eukaryota. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G1LR75; -. DR OMA; CRRCDHA; -. DR OrthoDB; EOG091G0BWK; -. DR TreeFam; TF325595; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0036019; C:endolysosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0003779; F:actin binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:1902350; P:cellular response to chloroquine; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl. DR GO; GO:0032741; P:positive regulation of interleukin-18 production; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl. DR GO; GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl. DR GO; GO:0050864; P:regulation of B cell activation; IEA:Ensembl. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; IEA:InterPro. DR GO; GO:0032640; P:tumor necrosis factor production; IEA:Ensembl. DR Gene3D; 3.40.20.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR002108; ADF-H. DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027181; TLR9. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24373:SF37; PTHR24373:SF37; 1. DR Pfam; PF00241; Cofilin_ADF; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00102; ADF; 1. DR SMART; SM00369; LRR_TYP; 17. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51263; ADF_H; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 38 170 ADF-H. {ECO:0000259|PROSITE:PS51263}. FT DOMAIN 994 1161 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1175 AA; 132098 MW; BDAE3DD99BD8FE35 CRC64; SCAAPAPLTS AERELQQIRI NEVKTEISVE SKHQTLQGLT FPLQPAAQRA LQQLKQRTIS YIQLKLDLER ETIELVHTEP TEVAQLPSRV PRDAARYHFF LYKHTHEGDP LESVVFIYSM PGYKCSIKER MLYSSCKSRL LDSVEQDFQL EISKKGPCSG ALHPLSLLVQ AAALAVVLAP GALPPFLPCE LQSRGLVNCD WLFLTSVPRF SAAAPRGNIT SLSLYSNRIR HLHDSDFVHL SSLRRLDLKW NCPPAGLSPM HFPCHMTIEP NTFLAVPTLE DLNLSYNGIS TVPALPSSLV SLSLSRTNIL VLDPGHLAGL HNLRYLFLDG NCYYKNPCRQ ALRVAPGALL GLRNLTHLSL KYNNLTMVPR HLPPSLEYLL LSYNHIITLA RDDLANLTAL RVLDVGGNCR RCDHARNPCR ECPRGFPKLH PDTFSHLSRL EGLVLKDSSL HSLDPRWFRG LGNLLVLDLS ENFLYDCITK TEAFRGLARL RRLNLSFNYH KKVSFAHLHL APSFGSLLSL QELDMHGIFF RSLSKTTLWP LVHLPLLQRL HLQLNFINQA QLSLFGAFPG LRHVDLSDNR ISGAAEPLAA ATGEADGPEQ AWRLPRNTAQ GRPGAPSSED FMPSCRTLNF TLDLSRNNVV SIQPEMFAQL SRLQCLCLSH NSISQAVNGS QFVPLTSLRV LDLSHNKLDL YHGRSFTELP RLEALDLSYN SQPFSMRGVG HNLSFVAQLP ALRYLSLAHN DIHSRVSQQL RSASLWALDF SGNVLSQMWA EGDLYLRFFR GLSSLVHLDL SQNRLHTLLP RNLDNLPKSL RLLRLRDNYL AFFNWSSLAL LPSLEALDLA GNQLKALSNG SLPNGTRLQR LDLSGNSIGF VVPGFFALAA GLRELNLSAN ALKTVEPSWF GSLAGALHVL DVTANPLHCA CGAAFVDFLL EVQDAVPGLP SHVRCGSPGQ LQGRSIFAQD LRLCLDEALS WDCFGLSMLA VALSLAVPVL HHLCGWDLWY CFHLCLAWLP RRGRRRGAVF DKAQSSVADW VYNELRVQLE ERRGRRALRL CLEERDWLPG RTLFENLWAS VYSSRKTLFV LAHTDSVSGL LRASFLLAQQ RLLEDRKDVV VLVMLRADAR PRSRYVRLRQ RLCRQSVLFW PHQPRGQRSF WAQLGTALTR DNRHFYNRNF CRGPT // ID G1LRM1_AILME Unreviewed; 440 AA. AC G1LRM1; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMEP00000009707}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009707, ECO:0000313|Proteomes:UP000008912}; RN [1] {ECO:0000313|Ensembl:ENSAMEP00000009707} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., RA Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., RA Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., RA Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., RA Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., RA Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., RA Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., RA Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., RA Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., RA Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., RA Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., RA Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., RA Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., RA Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., RA Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., RA Wang J., Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000009707} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ACTA01129533; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01137533; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ACTA01145532; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9646.ENSAMEP00000009707; -. DR Ensembl; ENSAMET00000010128; ENSAMEP00000009707; ENSAMEG00000009240. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G1LRM1; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008912}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 104 125 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 94 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 147 306 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 440 AA; 50521 MW; E5C1F69BDAA1D9C0 CRC64; LSAGDSANLT CRAFFGYSGD VSPLIYWMKG EKFIEDLDEN RVWESDIRIL KEHLGEQEVS ISLIVDSVEE GDLGNYSCYV ENGNGRRHAS VLLHKRELMY TVELAGGLGA ILLLLVCLVT IYKCYKIEIM LFYRNHFGAE ELDGDNKDYD AYLSYTKVDP DQWNQETGEE ERFALEILPD MLEKHYGYKL FIPDRDLIPT GTYIEDVARC VDQSKRLIIV MTPNYVVRRG WSIFELETRL RNMLVTGEIK VILIECSELR GIMNYQEVEA LKHTIKLLTV IKWHGPKCNK LNSKFWKRLQ YEMPFKRIEP ITHEQALDVS EQGPFGELQT VSAISMAAAT STALATAHPD LRSTFHNTYH SQMRQKHYYR SYEYDVPPTG TLPLTSIGNQ HTYCNIPMTL INGQRPQTKS SREQNPDEAH TNSAILPLLP RETSISSVIW // ID G1NPM7_MELGA Unreviewed; 555 AA. AC G1NPM7; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000015694}; GN Name=LOC100540676 {ECO:0000313|Ensembl:ENSMGAP00000015694}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000015694, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000015694, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000015694} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR Ensembl; ENSMGAT00000016653; ENSMGAP00000015694; ENSMGAG00000014808. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 555 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417370. FT TRANSMEM 339 359 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 19 112 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 142 214 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 386 543 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 555 AA; 63987 MW; 6F08C4BBC8ADC8F0 CRC64; MHKMTSTFLL IGHLILVIPL FSAEECVICN YFVLVGEPTA ISCPVITLPM PHSDYNLTWY KNGSSTPITT ERHARIHQRK GLLWFIPATL EDSGLYECEV RSLNRSKQKI INLKVFKNDN DLCFNGEMKY DQIVKSANAG KIICPDLENF KDEDNINPEI HWYKECKSGF LEDKRLVLAE GENAILILNA TIQDKGNYTC RMVYTFMGKQ YNVSRTMNLE VKESPLKMRP EFIYPNNNTI EVELGSHIVM ECNVSSGVYG LLPYWQVNDE DVDSFDSTYR EQFYEEGMPH GIAVSGTKFN ISEVKLKDYT YKFFCHFFYD SQEFTSYIKL EHPVQNIRGY LIGGGISLIF LLFLILVIYK TFKIDIVLWY RSSCHPFLGK KVSDGKIYDA YVLYPKNRES CLYSSDIFAL KILPEVLERQ CGYNLFIFGR NDLAGEAVIS ITDEKIHQSR RVIIILVPEP SCYGVLEDAS EKHLAVYNAL IQDGIKIILI ELEKIEDYAN MPESIKYVKQ KYGAIRWKGD FSERSHSAST KFWKKVRYHM PSRKHGSSSG FHLSP // ID G1NPM9_MELGA Unreviewed; 533 AA. AC G1NPM9; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 28-MAR-2018, entry version 38. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSMGAP00000015696}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSMGAP00000015696}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000015696, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000015696, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000015696} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR Ensembl; ENSMGAT00000016655; ENSMGAP00000015696; ENSMGAG00000014810. DR eggNOG; ENOG410IPTT; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 533 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003416757. FT TRANSMEM 323 343 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 103 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 106 194 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 207 314 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 368 523 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 533 AA; 61794 MW; A62F9C2BA516D9E7 CRC64; MMMYVHLIFL SIFLPASVIS ESYDAIEGEA LVVRCPENDL SAKVTWYHTD TRKRIPEEEE GSRVFSKELF LWFLPTSLED SGNYTCLINY PDGSKKGRKM NVQVHPYKRG MCFPSRILYA NETRKGKISC PTFKNYENAT IIQWYKDCRP LQGERYFMHD PYIFIENLNK EDDGYYTCQF TYTHRGKVFN VSATRIFISE AKHSSLPVEI LFPKDEDVKE VELGTAFSLK CQARLGIKKQ PIAVVTWDVN KIPAEYADEE KIHQEIIYFE GQHQEYYGEA TLTISNIEHT DLQSSFTCVA MNEMGNTRST VTLRLKEKSG PSVLMIAGFL VLLMSVAVSV VLYQSFRVDI ILLYRDLFQA YSVKDDGKIY DAYVIYPQSH TNEATFVEYF VYQMMPDILE NKCGXXXXXX XXXXXALLDK ANAIEKRIQK SRRLIILLTQ QLINCQELNY DQHIALYNAL IQNDTKVILL EMEKMGTYEN LQESLRYIIK QQGTVKWKEQ HTVHPQSSNS KFWKHVRYHM PVTFRSSDPA NAG // ID G1P974_MYOLU Unreviewed; 827 AA. AC G1P974; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 53. DE SubName: Full=Toll like receptor 4 {ECO:0000313|Ensembl:ENSMLUP00000006762}; GN Name=TLR4 {ECO:0000313|Ensembl:ENSMLUP00000006762}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006762, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006762, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006762} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAPE02022906; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02022907; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000006762; -. DR Ensembl; ENSMLUT00000007409; ENSMLUP00000006762; ENSMLUG00000007417. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G1P974; -. DR OMA; EDWVRNE; -. DR OrthoDB; EOG091G01RC; -. DR TreeFam; TF351113; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; IEA:Ensembl. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl. DR GO; GO:0005102; F:receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl. DR GO; GO:0014002; P:astrocyte development; IEA:Ensembl. DR GO; GO:0002322; P:B cell proliferation involved in immune response; IEA:Ensembl. DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl. DR GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032497; P:detection of lipopolysaccharide; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0050702; P:interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl. DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl. DR GO; GO:0032707; P:negative regulation of interleukin-23 production; IEA:Ensembl. DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl. DR GO; GO:0002537; P:nitric oxide production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl. DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl. DR GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl. DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl. DR GO; GO:0070430; P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; IEA:Ensembl. DR GO; GO:0070434; P:positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; IEA:Ensembl. DR GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; IEA:Ensembl. DR GO; GO:0010572; P:positive regulation of platelet activation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl. DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 12. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 827 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011109995. FT TRANSMEM 620 643 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 659 805 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 827 AA; 94492 MW; A329831D8068EA3B CRC64; IMWPTRLAGM LLPAMAFLSC LRPESWDPCV QVVPNVTYQC MELNLYKIPD NLPTSIKNLD LSFNPLRHLG SHSFSNFSEL QVLDLSRCEI QKIEDDAYQG LKHLSILILT GNPIQSLAPG AFSGLPSLQT LVAVETNLAS LEDFPIRHLK TLKELNVAHN LIDSFKLPDY FSNLPNLEHL DLSNNKIRNI YHEDLQVLHQ MPSFKLSLDL SLNPLDFIQP GAFEKIKLHE LTLRSNFDSA EVMKTCIQGL AGLKINRLIL GEFKNERTIV NFNKSALEGL CNLTIEEFRI AHFDEFPGDD LGFLNCLPEA STISLMGLYL DELKIFPKGF KWQYLNLSKC IFEHFPTLEL TFLKQFVFTA NKGITTFTKV NLPNLEFLDL SKNGLSYKSC CSHRDFGTTQ LKHLNLSFNN IISLDFQHST LKQASDFSVF LSLKNLLYLD ISYTNTKIVF LRIFDGLISL QVLKMAGNSF QDALLPNIFR DLTQLTELDL SQCQLERVSQ EAFGSLLRLQ VLNMSHNHLL SLDMLPFKNL SLRVLDCSFN RIVAANGQEL QHFPSNVTSL NLNQNNFACV CEHMRFLQWV QDHRHILVGA EHMMCEKPLA MQGVPVLSFR NATCQMSKTI ISVSVLSVLV VSVAAVLVYK FYFHLMLLAG CKKYGKGEST YDAFVIYSSH DEDWVRNELV KNLEEGVPPF QLCLHYRDFI PGVAIAANII QEGFHKSRKV IVVVSRHFIQ SRWCLFEYEI AQTWQFLSSH AGIIFIVLQK VERSLLRQQV ELYRLLSRNT YLEWEDSVLG RHIFWRRLRK ALLDGKPWSP EGTEDAESSQ DEATTST // ID G1PIP0_MYOLU Unreviewed; 437 AA. AC G1PIP0; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSMLUP00000010583}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSMLUP00000010583}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010583, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010583, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010583} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAPE02010495; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000010583; -. DR Ensembl; ENSMLUT00000011618; ENSMLUP00000010583; ENSMLUG00000011609. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G1PIP0; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50275 MW; 10E4BF02086CB499 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVQEGDL GNYSCYVENG NGRRHASILL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS NFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID G1PL83_MYOLU Unreviewed; 1041 AA. AC G1PL83; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 51. DE SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSMLUP00000011602}; GN Name=TLR8 {ECO:0000313|Ensembl:ENSMLUP00000011602}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011602, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011602, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011602} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAPE02017465; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G1PL83; -. DR STRING; 59463.ENSMLUP00000011602; -. DR Ensembl; ENSMLUT00000012752; ENSMLUP00000011602; ENSMLUG00000012745. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G1PL83; -. DR OMA; WPDNPKA; -. DR OrthoDB; EOG091G014D; -. DR TreeFam; TF351113; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0003677; F:DNA binding; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 17. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 1041 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003417234. FT TRANSMEM 827 848 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 878 1025 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1041 AA; 118780 MW; F15733E087BBF1FD CRC64; ENMTLPSLLL TCLVLLTSDS CGFSTETNYL RRSFPCDEKI QNGSSVTVGC NNRRLQEVPQ TVGPDVTELD LSDNSITRIT NGSFQRLHNL TTINLNRNAM LPPYFENYQR NKKGMNITDG AFLNLQKLTV LLLENNQLDK IPSGLPGSLR WLSLTQNNII SVTKNSTSGL MNLEILNLGW NCYFGNVCNK TFNADGAFEE MANLKELTLS FNNLSRVPRN LPRSLTKLYL SNTNINAVHG ADLENLGNLT VLDLSGNCPR CFNAPFPCTP CPGDASIFID GNAFDNLTKL EYLNLSSTSL RKINSSWFDK MPDLKELHLE FNYLVPEIAS GEFLTKLLSL EILDLSYNYI KAQYLEFITL SPNFSNLTYL RSLHLKGYVF QKLRYKDFQP LRNLSNLTTI NLGVNFINQI DFTIFNNFSN LKVIYLSANR ISPLVNGNRQ SSARLSSGHS HVLKPRSANS EFDPHSNFYH STKPLIKPEC EHYGQAIDLS LNNIFFIGQK QFKDFPPILC LNLSSNGNGQ ALNGSEFSAL PKLKYLDFSH NKLDFDADSA FNELPELEVL DLSNNEHYFQ IAGVTHRLGF IKNLTKLKVL NVSQNSIYTL TEYNLSSTSL KQLVFSGNRL DILWKAADKR YVCIFRNLNV LEELDISFNN LERIPKQAFI NLPRNLTKLY LNDNKLRFFN WTLLQHFPQL QLLDLSRNCL YYLTDSLSKI TSSLQTLLLS ENLIAHMPSG FVSENSSLVT LDLSSNKLKM INRSTFQTNK NSNLALLRLD GNPFDCTCDM GDFLRWMDEN LNVTIPRLTD VTCSSPGDQI GKSIVTLELT ACVSDTIAAI LCFFTSFLTL TVMLAALAHH WFYWDVWFIY HVCLAKVKGY RSLSTSQTFY DAYVSYDTKD ASVTDWVINE LRFHLEESEE KNVLLCLEER DWDPGLAIID NLMQSINQSK KTIFVLTRKY AGSWSFKTAF YLALQRLMDE NMDVIVFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EVLFWQSLKN VVLTENNSRY NSLYVDSIKQ Y // ID G1PUZ5_MYOLU Unreviewed; 599 AA. AC G1PUZ5; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSMLUP00000015131}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSMLUP00000015131}; OS Myotis lucifugus (Little brown bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015131, ECO:0000313|Proteomes:UP000001074}; RN [1] {ECO:0000313|Ensembl:ENSMLUP00000015131, ECO:0000313|Proteomes:UP000001074} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSMLUP00000015131} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAPE02045342; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAPE02045343; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59463.ENSMLUP00000015131; -. DR Ensembl; ENSMLUT00000016605; ENSMLUP00000015131; ENSMLUG00000016603. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G1PUZ5; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000001074; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001074}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001074}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 599 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003418685. FT TRANSMEM 361 388 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 148 237 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 250 352 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 408 564 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 599 AA; 67432 MW; E614E4A834EC1E52 CRC64; MLCLGWIFLW FVTGERIKGF NISGCSIKNF LWMYSAESAE EFVLFCDLAE PQKPRSYHRH PLSPAQGPAR RPCRGREGLS DAQWYLQPRE GGALKEITSN QSHLLLDKTA LRFLTAERSH AGSYICRPRM RSRRDEACCV KMVLEVQPQA DLSCAHPVPR TRYLRLGSTD SIHCPSLGCQ GGARSPEMTW YQNGRLLSAQ RSNPLQLDVI YDYHQGTYAC DYTQADGAGS RTVRAVVQVK TIVRNTTLKP DILEPVKDTL EVELGKPLTL NCTARFGFEE HFKPVLRWYS KDSGRELEIP TKEGRRVKAT VEAEVIQRTV HLERVAQSDL HKTFICFAQN SLGNSTQPLQ LRGRKGASPV VFLYVLLGTV AALAGALAAG ALLFTYWIEV VLLCRTCQDK DETLGDKKEF DAFISYAKGS ASESEPASPM SEDCLALKLF PEVLENKYGY TLCLLERDVA PGGVYTEDIV SIIKKSRRGV FILSPNYVNG PSVFELQAAV SLALDDQTLK LILVKFCPFQ EPESLPDLVR KALRVLPTVT WRGLKSAPPN SRFWTRLRYH MPMKNPTGLP WGHLRVISRA FWEDSKTETP GRSSQPRHW // ID G1RD05_NOMLE Unreviewed; 1049 AA. AC G1RD05; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 54. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSNLEP00000011104}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSNLEP00000011104}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011104, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011104} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011104} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADFV01194311; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01194312; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003261075.1; XM_003261027.3. DR STRING; 61853.ENSNLEP00000011104; -. DR Ensembl; ENSNLET00000011652; ENSNLEP00000011104; ENSNLEG00000009123. DR GeneID; 100585813; -. DR KEGG; nle:100585813; -. DR CTD; 51284; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G1RD05; -. DR KO; K05404; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000001073; Chromosome X. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 840 865 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 891 1036 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1049 AA; 120952 MW; 33A8EE6DE686AEAB CRC64; MVFPTWTLKR QILILFDIIL ISKLLGARWF PKTLPCDVTL DVPENHVIVD CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC VPIPLGSKNN MCTKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF LNLTKLKLLS LKDNNITTVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ LQILDLSGNC PRCYNAPFPC TPCENNSPLQ IPVNAFDALT ELKVLRLHSN SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP NLIQLDLSFN FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE VLDLGTNFIK IANLSMFKQF ERLKVIDLSV NKISPSGDSS EVGFCSNART SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL KLEELDISKN SLSSLPSGVF DGMPPNLKNL SLAKNGLKSF IWEKLQCLKN LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH TEVTIPYLAT DVTCVGPGAH KGQSVVSLDL YTCELDLTNL ILFSLSISVS LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV // ID G1RGF4_NOMLE Unreviewed; 696 AA. AC G1RGF4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 42. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSNLEP00000012304}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSNLEP00000012304}; OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates OS leucogenys). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hylobatidae; Nomascus. OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000012304, ECO:0000313|Proteomes:UP000001073}; RN [1] {ECO:0000313|Ensembl:ENSNLEP00000012304} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSNLEP00000012304} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Gibbon Genome Sequencing Consortium; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADFV01195151; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195152; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195153; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195154; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195155; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195156; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195157; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195158; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195159; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADFV01195160; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003261220.1; XM_003261172.2. DR ProteinModelPortal; G1RGF4; -. DR STRING; 61853.ENSNLEP00000012304; -. DR Ensembl; ENSNLET00000012903; ENSNLEP00000012304; ENSNLEG00000010091. DR GeneID; 100604188; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G1RGF4; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000001073; Chromosome X. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001073}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001073}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 696 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014190941. FT TRANSMEM 360 381 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 6 134 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 162 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 350 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 403 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 696 AA; 79969 MW; 9B7A0B503D73CCA9 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSIDIKK YQVLVGEPVR IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG DSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LVCLVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSSREQ NPDEAHTNSA ILPLLPRETS ISSVIW // ID G1T3W4_RABIT Unreviewed; 1043 AA. AC G1T3W4; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 28-MAR-2018, entry version 50. DE SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSOCUP00000010932}; GN Name=TLR8 {ECO:0000313|Ensembl:ENSOCUP00000010932}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010932, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010932, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010932} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010932}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAGW02002947; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9986.ENSOCUP00000010932; -. DR Ensembl; ENSOCUT00000012700; ENSOCUP00000010932; ENSOCUG00000012701. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G1T3W4; -. DR OMA; WPDNPKA; -. DR OrthoDB; EOG091G014D; -. DR TreeFam; TF351113; -. DR Proteomes; UP000001811; Chromosome 13. DR Bgee; ENSOCUG00000012701; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0003677; F:DNA binding; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 16. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT DOMAIN 877 1027 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1043 AA; 117149 MW; A8E970779EDFEF20 CRC64; TVAWLCLLTG CHAFLSSSDT THHSSRSYPC DERRQNGSVL AECNRRGLRE VPRTVSAYVT ELDLSNNLIA RITNASFPPL PNVTRINLNH NANRGQGNPS LRESGMQITD GAFLGLLRLR ELLLEDNQLG AIPAALPASL EELSLVQNSI VSVSKTHTAT LRHLRRLHLA WNCHFVCNKT FAAEDGAFAS LARLELLSLS FNNLARVPLG LPGSLRKLFL SNAGIARVGR DDFQGLHNLR LLDLSGNCPR CFNAPFPCTP CAGDSSIDIH PLAFQPLSRL AYLNLSSTSL RVVPASWFAN MTSLKVLHLE FNYLAHEMAA GEFLTQLPRL QVLDLSFNYR QAEYPLRLNV STNFAALRSL RALHLRGYVF QELRREDVRP LVALPRLKTI NLGVNFIRQI DFDLFQDFPG LRLIYLSENR ISPLVGGHDA QSSLGNVSLH RHGHRLQPRS ADPAFNPHAN FYHDTRPLVK PQCAAYGKAL DLSLNSIFFI GERQFASFRD VACLNLSSNG NAQVLRGTEF AALPRLKYLD LTDNRLDFDD DRALGELREL EVLDLSRNAH YFRVAGVTHR LGFLQNLTRL RVLNLSHNGI YTLTDHALRS ASLEELVFRG NRLDVLWGAD DHRYWPLFQG LHNLTQLDLS FNRLQRIPEQ AFLSLPRMLT ELRVSNNALR AFAWALLRTL PALRLLDLSA NRLTSVTRGL SAHAPSLRTL LLARNHIAQL PGGFLSGAAS LERLDLSANL LRTINRSTLA DDAAANTRLA VLELGGNPLD CSCAIRDFRA WMDEHPRITI PRLTDVACAS PGDQKGKSVV SLELATCVSD TVAAILFFFS FSVTAAVLGA ALAHHVFSWD VWFLYHVCLA KVRGYRSLST AAAAQHSVYD AYVSYDVRDA CVADWVINEL RRRLEEGEDG DSGKNVLLCL EDRDWDPGLA VIDNLARSIT ARRRFFVLTR KYACSWGFRT AFYLALQRLM EESADVIVFV LLEPALQHSR FLRLRRRLCR SSVLQWPDNP KAEGLFWHSL RHVVLTDNQS RYNHFYVDSI KQY // ID G3H6I2_CRIGR Unreviewed; 431 AA. AC G3H6I2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-FEB-2018, entry version 28. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:EGV92288.1}; GN ORFNames=I79_005943 {ECO:0000313|EMBL:EGV92288.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV92288.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JH000175; EGV92288.1; -; Genomic_DNA. DR ProteinModelPortal; G3H6I2; -. DR InParanoid; G3H6I2; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EGV92288.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 174 201 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 67 169 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 222 378 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 431 AA; 49329 MW; CD3D08C54CDAE4E6 CRC64; MGAAYHEELD GRLLPEYKNS IIQLGAIYDS YQGLYVCDYT QSDNVSSWTV RAVVQVRTIV KDINLKPDIL DPITDTLEVE LGKSLTLPCK VQFGFQRDFQ PVVKWYVKES TQEWEFNVFE EKSIQSNYKN EIIEHTIFLR EVTQRDLSRK FICFAQNSIG NTTRTIQLKK KEGVVFVYIL LGTAMMLAGI LVAAAFLYWY WIEIVLLCRA YKSKDETLRD KKEFNAFISY ANRSSPESEA AGSLSEEHLA LNLFPEVLEN KYGYTLCLLE RDVTPGGVYA DDIVNIIKKS RRGIFILSPS YVNGPCVFEL QAAVNLALVD QTLKLILIKF CSFQVPESLP YLVKKALRVL PTVTWRGLKS VQPSSRFWTQ ICYHMPVKNS NRFMYNRLRI IPRGFSPEQD LAREKPPRGV PGSGNSHGAR NLLLSSHQKR C // ID G3IMP6_CRIGR Unreviewed; 801 AA. AC G3IMP6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Toll-like receptor 10 {ECO:0000313|EMBL:EGW14354.1}; GN ORFNames=I79_025190 {ECO:0000313|EMBL:EGW14354.1}; OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW14354.1, ECO:0000313|Proteomes:UP000001075}; RN [1] {ECO:0000313|Proteomes:UP000001075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075}; RX PubMed=21804562; DOI=10.1038/nbt.1932; RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., RA Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., RA Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., RA Quake S.R., Famili I., Palsson B.O., Wang J.; RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell RT line."; RL Nat. Biotechnol. 29:735-741(2011). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JH004940; EGW14354.1; -; Genomic_DNA. DR InParanoid; G3IMP6; -. DR Proteomes; UP000001075; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027182; TLR10. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF23; PTHR24365:SF23; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001075}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:EGW14354.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000001075}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 570 593 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 624 768 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 801 AA; 92939 MW; E4997699632E68A4 CRC64; MLYNIIMSTE AWAPRLPEER ELISNFSNMA LREIPPDLTE ATTILDLSYN LLFQLQSSDF HSFSKLRFLI LCHNRIQQLD TKVFDLNREL SHLDLSYNRL KVIIWSSLAG LRHLDLSFND FDTLPTCEDI GNMPHLETLG LSGAKIQKSD LQKIAHLHLR AVLLGLRTLS HYEEGSLPIL NTTALHIVLP MNTNFWVLLC DGMKTSKVVE MTNIDGKSQF LSYETPWNLT VENTKASTLI FHKVDLLWDD LLLIFQFVWK TSVEYFRIQD LTFGGMANLD HSSFDYSNTV MKAIILEDIH FRIFYIPQDR IYLLFTQMDI ENLTISDAQM PHLLFPSHPQ SFQYLNFANN ILTDDLFKNP IQLPSLKTLI LRGNKLESLS LVSVFANSTP LLHLDLSQNL LQNEIEEPCL WPDTLTLLNL SSNKFEDSVF WCLPRKVQTL DLSHNRIQAV PRETIHLSAL RELRVAFNFL TDLPGCSHFT SLSMLNIEMN LILSPSLDFF RSCQELKTLN AGGNPFRCSC ELRDFIWLEK HSEGLMIGWP DSYICEYPLS LKGTPLKDVY LPEFSCNTTL LIVTVVLAML FLGMAVVFCW LNLDLLWYLR MLGQWIQIQH RVRKTMQKEP KRSVQFHTFI SYCAHDSVWV KNELIPNLQT EDVLICLPER NFDPYRSIAE NIISCTEKSC KSIFVLSPNF VQSEWCHYEF YLAHHNPFHD NYDSIILILL EPIPSYCIPP RFHKLKALLE KQVHLEWPKD RRKRGLFWVN LQAAINVNLI DTREKCELQT FTEPNVEHHG STTSLVRTDC L // ID G3QKJ0_GORGO Unreviewed; 696 AA. AC G3QKJ0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 38. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSGGOP00000002965}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSGGOP00000002965}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000002965, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000002965, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000002965} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CABD030123557; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123558; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123559; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123560; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123562; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123563; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123564; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123565; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CABD030123566; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_018875345.1; XM_019019800.1. DR RefSeq; XP_018875346.1; XM_019019801.1. DR STRING; 9593.ENSGGOP00000002965; -. DR Ensembl; ENSGGOT00000003031; ENSGGOP00000002965; ENSGGOG00000003017. DR GeneID; 101124247; -. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G3QKJ0; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000001519; Chromosome X. DR Bgee; ENSGGOG00000003017; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 696 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014177102. FT TRANSMEM 360 381 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 6 134 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 162 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 350 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 403 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 696 AA; 79969 MW; 9B7A0B503D73CCA9 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSIDIKK YQVLVGEPVR IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG DSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LVCLVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSSREQ NPDEAHTNSA ILPLLPRETS ISSVIW // ID G3S396_GORGO Unreviewed; 811 AA. AC G3S396; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 50. DE RecName: Full=Toll-like receptor {ECO:0000256|RuleBase:RU363040}; GN Name=TLR10 {ECO:0000313|Ensembl:ENSGGOP00000022546}; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Gorilla. OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022546, ECO:0000313|Proteomes:UP000001519}; RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022546, ECO:0000313|Proteomes:UP000001519} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Scally A.; RT "Insights into the evolution of the great apes provided by the gorilla RT genome."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022546} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU363040}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU363040}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|RuleBase:RU363040, ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CABD030027950; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_018880443.1; XM_019024898.1. DR RefSeq; XP_018880444.1; XM_019024899.1. DR RefSeq; XP_018880445.1; XM_019024900.1. DR ProteinModelPortal; G3S396; -. DR STRING; 9593.ENSGGOP00000022546; -. DR Ensembl; ENSGGOT00000033147; ENSGGOP00000022546; ENSGGOG00000025418. DR GeneID; 101126146; -. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G3S396; -. DR OMA; AYLEWPK; -. DR OrthoDB; EOG091G0356; -. DR TreeFam; TF351113; -. DR Proteomes; UP000001519; Chromosome 4. DR Bgee; ENSGGOG00000025418; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027182; TLR10. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF23; PTHR24365:SF23; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01463; LRRCT; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 4. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 9. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001519}; KW Immunity {ECO:0000256|RuleBase:RU363040, KW ECO:0000256|SAAS:SAAS00472892}; KW Inflammatory response {ECO:0000256|RuleBase:RU363040}; KW Innate immunity {ECO:0000256|RuleBase:RU363040, KW ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|RuleBase:RU363040, KW ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|RuleBase:RU363040, KW ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001519}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|RuleBase:RU363040}; KW Transmembrane {ECO:0000256|RuleBase:RU363040, KW ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|RuleBase:RU363040, KW ECO:0000256|SAAS:SAAS00598878}. SQ SEQUENCE 811 AA; 94579 MW; 973EDCAF641B9623 CRC64; MRLFRNIYIF CSIFMTVEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLSHY EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL TDELFKRTIQ LPHLKTLVLN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SILNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS YTCEYPLNLR GTPLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVS ATREMYELQT FTELNEESRG STISLMRTDC L // ID G3SU49_LOXAF Unreviewed; 437 AA. AC G3SU49; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSLAFP00000003644}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSLAFP00000003644}; OS Loxodonta africana (African elephant). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta. OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003644}; RN [1] {ECO:0000313|Ensembl:ENSLAFP00000003644} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003644}; RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., RA Lindblad-Toh K.; RT "The Genome Sequence of Loxodonta africana (African elephant)."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLAFP00000003644} RP IDENTIFICATION. RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003644}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3SU49; -. DR STRING; 9785.ENSLAFP00000003644; -. DR Ensembl; ENSLAFT00000004370; ENSLAFP00000003644; ENSLAFG00000004370. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G3SU49; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000007646; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007646}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007646}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50249 MW; FEC52E742A9BC580 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID G3UNV1_MELGA Unreviewed; 486 AA. AC G3UNV1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSMGAP00000017232}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSMGAP00000017232}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000017232, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000017232, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000017232} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3UNV1; -. DR Ensembl; ENSMGAT00000020251; ENSMGAP00000017232; ENSMGAG00000014810. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 2. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 486 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456872. FT DOMAIN 15 103 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 106 194 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 207 314 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 321 476 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 486 AA; 56622 MW; B0CAEF8BDA9E74DE CRC64; MMMYVHLIFL SIFLPASVIS ESYDAIEGEA LVVRCPENDL SAKVTWYHTD TRKRIPEEEE GSRVFSKELF LWFLPTSLED SGNYTCLINY PDGSKKGRKM NVQVHPYKRG MCFPSRILYA NETRKGKISC PTFKNYENAT IIQWYKDCRP LQGERYFMHD PYIFIENLNK EDDGYYTCQF TYTHRGKVFN VSATRIFISE AKHSSLPVEI LFPKDEDVKE VELGTAFSLK CQARLGIKKQ PIAVVTWDVN KIPAEYADEE KIHQEIIYFE GQHQEYYGEA TLTISNIEHT DLQSSFTCVA MNEMGNTRST VTLRLKEKYG KIYDAYVIYP QSHTNEATFV EYFVYQMMPD ILENKCGXXX XXXXXXXXAL LDKANAIEKR IQKSRRLIIL LTQQLINCQE LNYDQHIALY NALIQNDTKV ILLEMEKMGT YENLQESLRY IIKQQGTVKW KEQHTVHPQS SNSKFWKHVR YHMPVTFRSS DPANAG // ID G3UP79_MELGA Unreviewed; 563 AA. AC G3UP79; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMGAP00000017370}; GN Name=LOC100540676 {ECO:0000313|Ensembl:ENSMGAP00000017370}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000017370, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000017370, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000017370} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3UP79; -. DR STRING; 9103.ENSMGAP00000017370; -. DR Ensembl; ENSMGAT00000018904; ENSMGAP00000017370; ENSMGAG00000014808. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G3UP79; -. DR OMA; IQDYEKM; -. DR OrthoDB; EOG091G03IT; -. DR TreeFam; TF325519; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 563 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456493. FT TRANSMEM 347 367 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 41 117 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 147 219 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 394 551 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 563 AA; 65027 MW; 88055C62BE085930 CRC64; MTSTFLLIGH LILVIPLFSA GKEERNCKYS KEIIYYFVLV GEPTAISCPV ITLPMPHSDY NLTWYKNGSS TPITTERHAR IHQRKGLLWF IPATLEDSGL YECEVRSLNR SKQKIINLKV FKNDNDLCFN GEMKYDQIVK SANAGKIICP DLENFKDEDN INPEIHWYKE CKSGFLEDKR LVLAEGENAI LILNATIQDK GNYTCRMVYT FMGKQYNVSR TMNLEVKESP LKMRPEFIYP NNNTIEVELG SHIVMECNVS SGVYGLLPYW QVNDEDVDSF DSTYREQFYD NEREGMPHGI AVSGTKFNIS EVKLKDYTYK FFCHFFYDSQ EFTSYIKLEH PVQNIRGYLI GGGISLIFLL FLILVIYKTF KIDIVLWYRS SCHPFLGKKV SDGKIYDAYV LYPKNRESCL YSSDIFALKI LPEVLERQCG YNLFIFGRND LAGEAVISIT DEKIHQSRRV IIILVPEPSC YGVLEDASEK HLAVYNALIQ DGIKIILIEL EKIEDYANMP ESIKYVKQKY GAIRWKGDFS ERSHSASTKF WKKVRYHMPS RKHGSSSGFH LSP // ID G3UQ87_MELGA Unreviewed; 547 AA. AC G3UQ87; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSMGAP00000017757}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSMGAP00000017757}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000017757, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000017757, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000017757} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; G3UQ87; -. DR Ensembl; ENSMGAT00000018382; ENSMGAP00000017757; ENSMGAG00000014810. DR eggNOG; ENOG410IPTT; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G3UQ87; -. DR OMA; VQGTIKW; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0002113; F:interleukin-33 binding; IEA:Ensembl. DR GO; GO:0002114; F:interleukin-33 receptor activity; IEA:Ensembl. DR GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IEA:Ensembl. DR GO; GO:0090197; P:positive regulation of chemokine secretion; IEA:Ensembl. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 547 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457054. FT TRANSMEM 323 345 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 13 101 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 104 192 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 205 312 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 370 525 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 547 AA; 63679 MW; 30CA241E9F3689BA CRC64; MYVHLIFLSI FLPASVISES YDAIEGEALV VRCPENDLSA KVTWYHTDTR KRIPEEEEGS RVFSKELFLW FLPTSLEDSG NYTCLINYPD GSKKGRKMNV QVHPYKRGMC FPSRILYANE TRKGKISCPT FKNYENATII QWYKDCRPLQ GERYFMHDPY IFIENLNKED DGYYTCQFTY THRGKVFNVS ATRIFISEAK HSSLPVEILF PKDEDVKEVE LGTAFSLKCQ ARLGIKKQPI AVVTWDVNKI PAEYADEEKI HQEIIYFEGQ HQEYYGEATL TISNIEHTDL QSSFTCVAMN EMGNTRSTVT LRLKEKCYLH HSALFYSIAG FLVLLMSVAV SVVLYQSFRV DIILLYRDLF QAYSVKDDGK IYDAYVIYPQ SHTNEATFVE YFVYQMMPDI LENKCGLKLC VFPEKKYTLL DKANAIEKRI QKSRRLIILL TQQLINCQEL NYDQHIALYN ALIQNDTKVI LLEMEKMGTY ENLQESLRYI IKQQGTVKWK EQHTVHPQSS NSKFWKHVRY HMPVTFRSSD PANAGAYILG KSNLFSF // ID G3USU2_MELGA Unreviewed; 1047 AA. AC G3USU2; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 54. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSMGAP00000018774}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSMGAP00000018774}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000018774, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000018774, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000018774} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR RefSeq; XP_010724773.1; XM_010726471.2. DR Ensembl; ENSMGAT00000020832; ENSMGAP00000018774; ENSMGAG00000014706. DR GeneID; 100542671; -. DR KEGG; mgp:100542671; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR KO; K05404; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1047 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457070. FT DOMAIN 887 1034 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1047 AA; 120309 MW; B44F8232BE4E6558 CRC64; MVRHAKMSNA LLIVLLFLFP MLLLGYWFPK TLPCDVEAFE GTVRVDCSDR HLTEVPRGIP GNATNLTLTI NHIPHISPAS FIQLENLVEI DFRCNCVPVR LGPKDSVCTT PPSIENGSFA ALTRLKSLYL DANQLSEIPQ DLPATLRLLS LEANRIFSIK KNTFSGLRNI ELLYLGQNCY YRNPCNVSFG IEKTAFLNLK NLTVLSLKSN NLTFIPPNLS STLKELYIYN NRIQEVQEHD LSTLHNLEIL DLSGNCPRCY NAPYPCTPCP NISIKIHSKA FYSLKKLRIL RLHSNSLRSI PSSWFKNIKN LKNLDLSQNF LIKEIGDAQF LKLIPSLVEL DLSFNFELQM YSPSLNLSKT FSSLSNLETL RIKGYVFKEL REGNLDPLLS LRNLTVLDLG TNFIKIADLR VFKKFQALKI IDLSLNKISP SSGESNFYGF CSDPRITVEQ YSRQVSQEMH YFRYDEYGRS CKSKDKEADS YQPSVNGDCM SYGKTLDLSR NNIFFVNSVD FQDLSFLKCL NLSGNAISQT LNGSEFYYLS GLKYLDFSNN RIDLLYSTAF KELKFLEILD LSNNKHYFLA EGVSHVLSFM KNLAYLKKLM MNENEISTSI SMGMESQSLQ TLEFRGNRLD IFWADGKTEY LSFFKNLTKL EQLDISSNML SFLPPDVFSA MPPELKILNL TSNQLKTFNW GKLHLLTKLK TLDLSNNLLT TVPRKLSNCT STLQELILRN NRIIRITKYF LRGAIKLSYL DLSSNKIQII KKSSFPENII NNLRMLFLHN NPFKCNCDAV WFVGWINQTH VTIPLLATDV TCAGPGAHKG RSLVFLDLNT CELDTSYLIM YALSTSAVLS LITFAVMSHF YFWDVWYSYH YCTAKLKGYR RLPLPDACYD AFIAYDNTDL AVNEWVMTEL VEKLEDQKAK QFNLCLEERD WLPGQPVFDN LSQSIQLSKK TIFVLTNKYI KSGTFKTTFY MAHQRLLDEK IDVIILIFLE RVLQKSRYVR LRKRLCRSSV LEWPTNPRSQ PYFWQCLKNA IAMNNTLAYN KLLQETV // ID G3UUE3_MELGA Unreviewed; 1053 AA. AC G3UUE3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 52. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSMGAP00000019405}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSMGAP00000019405}; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000019405, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000019405, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000019405} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 9103.ENSMGAP00000019405; -. DR Ensembl; ENSMGAT00000018738; ENSMGAP00000019405; ENSMGAG00000014706. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; G3UUE3; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 16 34 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 893 1040 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1053 AA; 121051 MW; 73F0DBC04CC2411F CRC64; LRKKAFEVRH AKMSNALLIV LLFLFPMLLL GYWFPKTLPC DVEAFEGTVR VDCSDRHLTE VPRGIPGNAT NLTLTINHIP HISPASFIQL ENLVEIDFRC NCVPVRLGPK DSVCTTPPSI ENGSFAALTR LKSLYLDANQ LSEIPQDLPA TLRLLSLEAN RIFSIKKNTF SGLRNIELLY LGQNCYYRNP CNVSFGIEKT AFLNLKNLTV LSLKSNNLTF IPPNLSSTLK ELYIYNNRIQ EVQEHDLSTL HNLEILDLSG NCPRCYNAPY PCTPCPNISI KIHSKAFYSL KKLRILRLHS NSLRSIPSSW FKNIKNLKNL DLSQNFLIKE IGDAQFLKLI PSLVELDLSF NFELQMYSPS LNLSKTFSSL SNLETLRIKG YVFKELREGN LDPLLSLRNL TVLDLGTNFI KIADLRVFKK FQALKIIDLS LNKISPSSGE SNFYGFCSDP RITVEQYSRQ VSQEMHYFRY DEYGRSCKSK DKEADSYQPS VNGDCMSYGK TLDLSRNNIF FVNSVDFQDL SFLKCLNLSG NAISQTLNGS EFYYLSGLKY LDFSNNRIDL LYSTAFKELK FLEILDLSNN KHYFLAEGVS HVLSFMKNLA YLKKLMMNEN EISTSISMGM ESQSLQTLEF RGNRLDIFWA DGKTEYLSFF KNLTKLEQLD ISSNMLSFLP PDVFSAMPPE LKILNLTSNQ LKTFNWGKLH LLTKLKTLDL SNNLLTTVPR KLSNCTSTLQ ELILRNNRII RITKYFLRGA IKLSYLDLSS NKIQIIKKSS FPENIINNLR MLFLHNNPFK CNCDAVWFVG WINQTHVTIP LLATDVTCAG PGAHKGRSLV FLDLNTCELD TSYLIMYALS TSAVLSLITF AVMSHFYFWD VWYSYHYCTA KLKGYRRLPL PDACYDAFIA YDNTDLAVNE WVMTELVEKL EDQKAKQFNL CLEERDWLPG QPVFDNLSQS IQLSKKTIFV LTNKYIKSGT FKTTFYMAHQ RLLDEKIDVI ILIFLERVLQ KSRYVRLRKR LCRSSVLEWP TNPRSQPYFW QCLKNAIAMN NTLAYNKLLQ ETV // ID G3V6F8_RAT Unreviewed; 871 AA. AC G3V6F8; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 61. DE SubName: Full=RCG20122 {ECO:0000313|EMBL:EDL94883.1}; DE SubName: Full=Toll-like receptor 5 {ECO:0000313|Ensembl:ENSRNOP00000004821}; GN Name=Tlr5 {ECO:0000313|Ensembl:ENSRNOP00000004821, GN ECO:0000313|RGD:631351}; GN ORFNames=rCG_20122 {ECO:0000313|EMBL:EDL94883.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000004821, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000004821, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004821, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|EMBL:EDL94883.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL94883.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] {ECO:0000313|EMBL:EDL94883.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL94883.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSRNOP00000004821} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000004821}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AABR07021972; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH473985; EDL94883.1; -; Genomic_DNA. DR RefSeq; NP_001139300.1; NM_001145828.1. DR RefSeq; XP_006250438.1; XM_006250376.2. DR RefSeq; XP_017454221.1; XM_017598732.1. DR RefSeq; XP_017454222.1; XM_017598733.1. DR RefSeq; XP_017454223.1; XM_017598734.1. DR UniGene; Rn.198962; -. DR STRING; 10116.ENSRNOP00000004821; -. DR Ensembl; ENSRNOT00000004821; ENSRNOP00000004821; ENSRNOG00000022067. DR GeneID; 289337; -. DR KEGG; rno:289337; -. DR CTD; 7100; -. DR RGD; 631351; Tlr5. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR KO; K10168; -. DR OMA; KYDAYLC; -. DR OrthoDB; EOG091G030N; -. DR TreeFam; TF351113; -. DR Proteomes; UP000002494; Chromosome 13. DR Bgee; ENSRNOG00000022067; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IDA:RGD. DR GO; GO:0005149; F:interleukin-1 receptor binding; ISO:RGD. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD. DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD. DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0008584; P:male gonad development; IEP:RGD. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IDA:RGD. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; ISO:RGD. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027176; TLR5. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44698:SF2; PTHR44698:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 653 673 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 704 840 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 871 AA; 99625 MW; 91B0160F580DD160 CRC64; MWCFYSLFSH RIMAYQLDLL IGVVFMASPV LEMSPCFSDG RIALFRGCNL TQIPWVLNTT ERLLLSFNYI STVVTTSFPL LEQLLLLELG TQYARLTIGQ EAFRNLPNLR ILDLGQSQIE VLNPDAFQGL PHLFELRLFD CGLSNAVLRD AYFRNLNSLA RLDLSANEIH SLHLHSSFQE LSSLSDINFS FNRIFTLCED ELQPLQGRTL SFFGLKSTSL FSRVFVDWEA CRNPLRGIRL ETLDLSENGW TAAILGNFSH TIQGSHISSL ILTYHIMGSG FGFQNIKDPD QSTFASLARS SVLQLDLSHG YIFSLNPRLF ETLKDLKKLN LAFNKINKIS DYAFHGLDSL QILNLSYNLL GELYNSNFYG LPSIAYLDLQ RNHIGIIQDR TFRLLKKLQT LDLRDNALKT IGFIPSVQMV LLGSNKLTHL PHVRFTANFI ELSENGLENL SDLYFLLRIP GLQFLILNQN RLSSCSNVDY APSQNLSLEQ LFLAENMLQL AWETGLCWDI FKGLSRLQIL YLNNNYLNFL PPGIFNGLVA LRMLSLSANR LTMLSPGSLP ANLEILDISR NQLFSPDPGL FSSLRALDIT HNEFICDCEL STFIVWLNQT NVTLFGSPAD VYCMYPNSLL GSSLYNISTK DCDEEEAVRS LNFSLFILCT VTLTLFLVIT LIVTKFRGIC FLCFKTIQKL MFKGKFRNPE PSAYRYDAYF CFSSKDFEWA QNALLKHLDA QYSSQNRLRL CFEERDFIPG ENHISNIQAA VWGSRKTVCL VSRHFLKDGW CLEAFRYAQS RCLSDLKRVL IVVVVGSLPQ YQLMRHETIR GFLQKQQYLR WPEDLQDVDW FLDKLSGCIL KEEKGKKRSS PIQLRTIRTV S // ID G3W3H1_SARHA Unreviewed; 437 AA. AC G3W3H1; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000009976}; DE Flags: Fragment; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSSHAP00000009976}; OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus. OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009976, ECO:0000313|Proteomes:UP000007648}; RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21709235; DOI=10.1073/pnas.1102838108; RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.; RT "Genetic diversity and population structure of the endangered RT marsupial Sarcophilus harrisii (Tasmanian devil)."; RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011). RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009976} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AEFK01105499; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01105500; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01105501; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AEFK01105502; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9305.ENSSHAP00000009976; -. DR Ensembl; ENSSHAT00000010063; ENSSHAP00000009976; ENSSHAG00000008633. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; G3W3H1; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000007648; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007648}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007648}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSSHAP00000009976}. SQ SEQUENCE 437 AA; 50317 MW; 81C7F6F0129B75EE CRC64; GNLANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTVYK CYKIDIMLFY RNHFGTEEID GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPISH EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSNRE QNPDEAHTNS AILPLLPRET SISSVIW // ID G5AXM8_HETGA Unreviewed; 1356 AA. AC G5AXM8; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 28-FEB-2018, entry version 40. DE SubName: Full=Toll-like receptor 9 {ECO:0000313|EMBL:EHB01789.1}; GN ORFNames=GW7_07749 {ECO:0000313|EMBL:EHB01789.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01789.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHB01789.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JH167404; EHB01789.1; -; Genomic_DNA. DR InParanoid; G5AXM8; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0003779; F:actin binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.20.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR002108; ADF-H. DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027181; TLR9. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24373:SF37; PTHR24373:SF37; 1. DR Pfam; PF00241; Cofilin_ADF; 2. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00102; ADF; 2. DR SMART; SM00369; LRR_TYP; 16. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51263; ADF_H; 2. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EHB01789.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1141 1162 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 4 139 ADF-H. {ECO:0000259|PROSITE:PS51263}. FT DOMAIN 177 313 ADF-H. {ECO:0000259|PROSITE:PS51263}. FT DOMAIN 1192 1340 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 190 210 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1356 AA; 152120 MW; 4A0B76235B776A92 CRC64; MAHQTGIHAT EELKEFFAKA RAGSVRLIKV IIEDEQLVLG ASQEPMGRWD QDYDRAVLPL LDAQQPCYML FRLDSQNAQG FEWLFLAWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE LFGTVKDDLS FAGYQKHLSS CAAPAPLTSA ERELQQIRIN EVKTEISVES KHQTLQGLAF PLQPEAQRAL QQLKQKTINY IQLKLDLERE TIELVHTEPT DVIQLPSRVP RDAARYHFFL YKHTHEGDPL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DSVEQDFQLE ISKKIEIGDG AELTAEFLYD EVHPKQHAFK QAFAKPKGPG GKRGHKRLIR GPVQAVALAE ALALGALPAF LPCELQPHGV VNCNWLFLKS VPRFSAAAPR SNVTSLSLLS NRIHHLHNSD FVHLPNLRHL NLKWNCPPTG LSPMHFPCHM TIEPKTFLAV PTLEDLNLSY NSITTVPALP SSLVNLTLSH TNILVLDSTS LTGLPALRVL FMDGNCYYKN PCHQALEVAP GALLGLGNLT HLSLKYNNLT KVPRDLPPSL EFLLLSYNHI FKLEPGDLVN LTALRVLDVG GNCRRCDHAR NPCVECLNKT LQLHPNTFSH LSHLEGLVLK DSSLHTLEPR WFRGLENLTV LDLSENFLYD SITKTRAFQG LARLRKLNLS FNYCKRVSFA HLQLAPSFGN LTSLQELDMN GIFFRSLSEN TLKPLTHLPL LQTLNLQMNF INQAQLSIFG AFPGLRFVDL SDNRISGAPT QKGLGEADDR EQVWLGPEDL APAPLGNPTS EDFMPSCKHF PFTLDLSGNN LVTVKSEMFT NLSRLQCLIL SHNCIAQAVN GSQFQTLTSL QVLDVSHNKL DLYHGHSFTE LPQLKALDLS YNSQPFGMQG IGHNLSFVAR LHKLQYLSLA HNGINSRVNP RLCSSSLRAL DFSGNTVSSM WAEGDLYLHF FQGLQGLLWL DLSHNHLHTL LPCNLDSLPK SLTLLLLRDN YLAFFNWSSL VLLPNLQTLD LAGNQLKALT NGTLPNGTQL QRLDVSGNSI SFVASGFFAL ATKLRELNLS DNILRTIDSS WFGTLAGSLK VLDVSANPLH CTCGAAFVDF LLEVQAAVPG LPNHIKCGSP SQLQGRSIFA QDLRLCLDEA LSWYCFGLSL LVVALGLVVP VLQHLCGWDL WYCFHLGLTW LPRWGPSGAQ ALPYDAFVIF DKTQGAVADW VYQELRVQLE ERRGFRALRL CLEERDWVPG KTLFENLWAS IYGSCKTVFV LAHTDRVSGL LRTGFLLAQQ RLLEDRKDIV VLVILSPDAH RSRYVRLRQR LCHRSVLFWP QQPRGQGSFW AQLSTALTRD NRHFYNQNFC RGLAAE // ID G5AZF1_HETGA Unreviewed; 548 AA. AC G5AZF1; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 25-OCT-2017, entry version 26. DE SubName: Full=Interleukin-1 receptor-like 1 {ECO:0000313|EMBL:EHB02415.1}; DE Flags: Fragment; GN ORFNames=GW7_06527 {ECO:0000313|EMBL:EHB02415.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02415.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHB02415.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JH167614; EHB02415.1; -; Genomic_DNA. DR ProteinModelPortal; G5AZF1; -. DR InParanoid; G5AZF1; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EHB02415.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 548 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003473794. FT TRANSMEM 326 358 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 11 101 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 112 195 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 204 316 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 372 542 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHB02415.1}. FT NON_TER 548 548 {ECO:0000313|EMBL:EHB02415.1}. SQ SEQUENCE 548 AA; 62465 MW; 5AE2C3E28DC205FE CRC64; GLWILAILTV PIYFTAAKGK SSWGQENEAL LVRCPKQGGS RYPVDWYYMK TNENIPTQKR NRVFASGEWL KFLPAKVGDS GIYTCVIRSP TWNKTRHTNV TIYKRPTDCH IPDYLMYSTV SGSERNSRIY CPTIDLYNWT APLKWFKNCK ALHGSRYRTH RSYLFIDNVG RDDEGDYTCK FTHTESGVNY SVTATRSFTV KDKPGVSVFP VIVTPSYNET KEVEIGKAAN ITCIACFGSG IQSFIAVLWQ VNGSNVKDLG IARIQEEQVQ NRSFSNDTCL NAMLRITKVK EEDLSLQYDC LATNFHGVIR HTTRLTEKKP IGCQSIYYIA AGCSILLMLI NLTVIILKVF WIDLILLWRD LTRPYKTRND GKLYDAYVIY PRDVTHGSEG LSSVEYFVHQ ILPDVLENKC GYNLCLYGRD LLPGEDVATA VEASIQKSRR HLFILTPHVS HSKEFAYEQE VALHCALIQN DSKVILIEME AEDEPGRLEA APGRLEAAGL QDSLSHLVQV QGTIKWREDH MANKRSLNSK FWKHVRYQMP VPSRSPQR // ID G5BA96_HETGA Unreviewed; 1032 AA. AC G5BA96; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:EHB06207.1}; GN ORFNames=GW7_05279 {ECO:0000313|EMBL:EHB06207.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06207.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHB06207.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JH169221; EHB06207.1; -; Genomic_DNA. DR ProteinModelPortal; G5BA96; -. DR InParanoid; G5BA96; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:EHB06207.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 823 848 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 874 1019 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1032 AA; 120117 MW; 23C71D5CD2C6C480 CRC64; MMLISRLLGA RWFPKTLPCD ISLDPSKTHV IVDCTDKHLT EIPEGIPTNA TNLTLTINHI PSISPDSFHN LDHLIEVDFR CNCVPIRMGA KKNMCVRRLQ IKPRSFSRLT YLKSLYLDGN QLLEIPQDLP PSLQLLSLEA NNIFVIMKEN LTELVNIEML FLGQNCYYRN PCNVSYSIEK NAFLNLRNLK VLSLKDNNIT AVPTLLPSNL TELYLYNNII TNIQEDDFNN LNQLEILDLS GNCPRCYNVP FPCIPCENNS PLQIHVNAFD ALTELQVLRL HSNSLQHVPV RWFKNMKNLR ELDLSQNYLA KEIGDAKFLH LLPNLIQLDL SFNYELQVYH AFINLSHSFS SLKNLKILRI KGYVFKELRY LNLSPLHDLH NLEVLDLGTN FIKIANLSIF KQFQKLKFID LSMNKISPSE DSSEIGFCSN TRTSVESNGP QVLETLHYFR YDKYARSCRF KNMETPFLTF NNDCNMYGQT LDLSRNNIFF VKPSDFQHLS FLKCLNLSGN TIGQTLNGSE FQHLEQLKYL DFSNNRLDLL HSTAFEELHN LEVLDLSMNS HYFQSEGITH MLNFTKNLKF LKKLMMNDND ISTSTSRTME SKSLKILEFR GNHLDILWRD GDNRYLKFFK NLLNLEELDI SRNSLSFLPP GVFDGMPPNL KTLSLAKNGL QTFNWRKLSF LKNLEILDLS HNQLTTLPER LSNCSRSLKK LILMKNQIRH LTKYFLKDAF QLRYLDLSSN KIQVIQKTSF PQNVLNNLEM LLLHRNRFLC NCDAVWFVWW VNHTDVTIPY LATEVTCVGP GAHKGQSVVS LDLYTCELNL INLILFSVSI SVALFLMVVM TASHLYFWDM WYIYHFFKAK LRGYQRLRSA ECCYDAFIVY DTKDPAVTEW VLDELVARLE DPREKHFNLC LEERDWLPGQ PVLENLSQSI QLSKKTVFVM TEKYAKTENF KIAFYLSHQR LMDEKVDVII LIFLEKPFTK SKFLQLRKRL CGSSVLEWPT NPQAHPYFWQ CLKNALAMDN HVVYSQMFKE TV // ID G5C728_HETGA Unreviewed; 670 AA. AC G5C728; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 28-FEB-2018, entry version 30. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:EHB17339.1}; DE Flags: Fragment; GN ORFNames=GW7_10261 {ECO:0000313|EMBL:EHB17339.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17339.1, ECO:0000313|Proteomes:UP000006813}; RN [1] {ECO:0000313|EMBL:EHB17339.1, ECO:0000313|Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., RA Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L., RA Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.; RT "Genome sequencing reveals insights into physiology and longevity of RT the naked mole rat."; RL Nature 479:223-227(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; JH173666; EHB17339.1; -; Genomic_DNA. DR InParanoid; G5C728; -. DR Proteomes; UP000006813; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006813}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EHB17339.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000006813}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 334 355 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 20 108 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 136 206 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 216 324 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 377 536 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHB17339.1}. SQ SEQUENCE 670 AA; 77141 MW; A8C6C271FDDE5417 CRC64; TADGCTDWSI DIKKYQVLVG EPVRIKCALF YGYIRTNYSL AQSAGLSLMW YKSSGPGDFE EPIAFDGSRM SKEEDSIWFR PTLLQDSGLY ACVIRNSTYC MKVSISLTVG ENDTGFCYNS KMKYFEKAEL SKSKEIACRD IEDFLLPTRE PEILWYKECR TKTWRHSIVF KRDTLLIREV REDDIGNYTC ELKYGSFVVR RTTELTVTAP LTDKPPKLLY PVESKLTIQE TQLGDSANLT CRAFFGYSGD VSPLIYWMKG EKFIEDLDEN RIWESDIRIL KEHLGEKEVS ISLIVNSVEE GDLGNYSCYV ENGNGRRHAS VLLHKRELMY TVELAGGLGA ILLLLVCLVT IYKCYKIEIM LFYRNHFGAE ELDGDNKDYD AYLSYTKVDP DQWNQETGEE ERFALEILPD MLEKHYGYKL FIPDRDLIPT GTYIEDVARC VDQSKRLIIV MTPNYVVRRG WSIFELETRL RNMLVTGEIK VILIECTELR GIMNYQEVEA LKHTIKLLTV IKWHGPKSNK LNSKFWKRLQ YEMPFKRIEP ITHEQALDVS EQGPFGELQT VSAISMAAAT STALATAHPD LRSTFHNTYH SQMRQKHYYR SYEYDVPPTG TLPLTSIGNQ HTYCNIPMTL INGQRPQTKS SREQNPDEAH TNSAILPLLP RETSISSVIW // ID G7PMU9_MACFA Unreviewed; 598 AA. AC G7PMU9; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 28-FEB-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHH55794.1}; GN ORFNames=EGM_05065 {ECO:0000313|EMBL:EHH55794.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH55794.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH55794.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM001288; EHH55794.1; -; Genomic_DNA. DR Proteomes; UP000009130; Chromosome 13. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 598 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003502565. FT TRANSMEM 359 382 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 149 235 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 251 353 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 406 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 598 AA; 68065 MW; B1D055EC1532A846 CRC64; MLCLGWMFLW LVSGERIKGF NISGCSTKKL LWAYSTRSEE EFILFCDLPE PQKSHFCHRS QLSPTQVPDH LPFTDSKDLP DVQWYRQPSN GDPLEDIRKS YPHIIQDKCT LRFLTPGVNN TGSYICRPKM IKSPYDVACC VKMILEVKPQ SNASCENSAS HKQDLLLGST GSISCPSLSC QSDAQSPEVT WYKNGKLLSM TRSNRIVVDE VYIYHQGTYV CDYTQSDTAS SWTVRAVVQV RTIVGDTKLK PDILDPVEST LEVELGKPLT ISCKARFGFE RVFNPVMKWY IKDADLEWEV SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRTFVCFVQ NSIGNTTQSV QLKEKRGVVL LYILLGTIGT LVAVLVASAL LYRHWIEIVL LYRTYQSKDE TLGDKKDFDA FVSYAKWSSF PSEATSSLTE EHLALSLFPD VLENKYGYTL CLLERDVAPG GVYAEDIVSV IKRSRRGIFI LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR FWTKMRYHMP VKNSQGFTWS QLRITSRIFQ WKGLSTTETT GRSSQPKE // ID G7Q2F4_MACFA Unreviewed; 667 AA. AC G7Q2F4; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 25-OCT-2017, entry version 24. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:EHH60783.1}; DE Flags: Fragment; GN ORFNames=EGM_18644 {ECO:0000313|EMBL:EHH60783.1}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130}; RN [1] {ECO:0000313|EMBL:EHH60783.1, ECO:0000313|Proteomes:UP000009130} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH60783.1}; RX PubMed=22002653; DOI=10.1038/nbt.1992; RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., RA Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., RA Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., RA Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., RA Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., RA Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., RA Wang X., Wang J.; RT "Genome sequencing and comparison of two nonhuman primate animal RT models, the cynomolgus and Chinese rhesus macaques."; RL Nat. Biotechnol. 29:1019-1023(2011). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM001296; EHH60783.1; -; Genomic_DNA. DR Proteomes; UP000009130; Chromosome X. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000009130}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EHH60783.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000009130}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 332 353 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 18 106 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 134 204 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 214 322 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 375 533 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:EHH60783.1}. FT NON_TER 667 667 {ECO:0000313|EMBL:EHH60783.1}. SQ SEQUENCE 667 AA; 76785 MW; 65AA47586F73560A CRC64; DGCTDWSIDI KKYQVLVGEP VRIKCALFYG YIRANYSLAQ SAGLSLMWYK SSGPGDFEEP IAFDGSRMSK EEDSIWFRPT LLQDSGLYAC VIRNSTYCMK VSISLTVGEN DTGLCYNSKM KYFEKAELSK SKEISCRDIE DFLLPTREPE ILWYKECRTK TWRPSIVFKR DTLLIREVRE DDIGNYTCEL KYGGFIVRRT TELTVTAPLT DKPPKLLYPM ESKLTIQETQ LGDSANLTCR AFFGYSGDVS PLIYWMKGEK FIEDLDENRV WESDIRILKE HLGEQEVSIS LIVDSVEEGD LGNYSCYVEN GNGRRHASVL LHKRELMYTV ELAGGLGAIL LLLVCLVTIY KCYKIEIMLF YRNHFGAEEL DGDNKDYDAY LSYTKVDPDQ WNQETGEEER FALEILPDML EKHYGYKLFI PDRDLIPTGY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID H0VQA7_CAVPO Unreviewed; 564 AA. AC H0VQA7; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSCPOP00000012719}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSCPOP00000012719}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012719}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000012719} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012719}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012719} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012719}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAKN02027911; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_013010001.1; XM_013154547.1. DR STRING; 10141.ENSCPOP00000012719; -. DR Ensembl; ENSCPOT00000014262; ENSCPOP00000012719; ENSCPOG00000014120. DR GeneID; 100730828; -. DR CTD; 8807; -. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H0VQA7; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR Bgee; ENSCPOG00000014120; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 564 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003542268. FT TRANSMEM 359 386 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 51 139 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 155 222 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 252 354 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 407 563 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 564 AA; 63674 MW; 84CCD04055C3752E CRC64; MLAWGWVFLW LLGRERIAGL NVAGCFIQKL LWTYCPGKEE EFVLFCDTPE PQRSRLFPGN QHNRTQGPRA LPCAGGKDLV DVRWYRQHRD GGPVEAIAGG HSHVTQREST LHFSSPEAAQ AGTYICRARI RSAPDVQVTC CLKTLLEVAP QTTAPCAASA PHKQYLLLGT VGSIRCPRLS CRGNTHRPEV TWYQNGRVLP GEKSDSILLE DIYDYHQGTY VCDYTVSPNV TSWTARAVVQ VRTIVADTKF KPDIVYPAKD TLEVELGKPL TLPCTVRFGF QRDLHPVIRW YIKSAGQQWE FPTFQEKSVK STMEEEVMER VIFLKEVTQS DLGREFLCFA QNSIGNVTRS LRLQEKRGVL LFYVLLGTVS ILVGVLAAGV LVYTYWIEIL LLYQTCQRKG ETLGDKKEFD AFVSYAKWGS MGSEDEAPLS EEQLALILFP EVLENKYGFT LCLLERDVAP GGVYSEDIVN VIKKSRRGIF ILSPNYLNGP QLFELQAAVN LALNDQMLKL ILIKFCSFQE PESLPLLVKK ALRVLPTITW RGLKSVAPNS RFWTQVRCHM PVKS // ID H0VT00_CAVPO Unreviewed; 777 AA. AC H0VT00; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 49. DE SubName: Full=Toll like receptor 10 {ECO:0000313|Ensembl:ENSCPOP00000013773}; GN Name=TLR10 {ECO:0000313|Ensembl:ENSCPOP00000013773}; OS Cavia porcellus (Guinea pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Caviidae; Cavia. OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013773}; RN [1] {ECO:0000313|Ensembl:ENSCPOP00000013773} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013773}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013773} RP IDENTIFICATION. RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013773}; RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAKN02028001; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAKN02028002; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 10141.ENSCPOP00000013773; -. DR Ensembl; ENSCPOT00000015432; ENSCPOP00000013773; ENSCPOG00000015283. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; H0VT00; -. DR OrthoDB; EOG091G0356; -. DR TreeFam; TF351113; -. DR Proteomes; UP000005447; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027182; TLR10. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF23; PTHR24365:SF23; 2. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 5. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005447}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000005447}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 549 571 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 604 744 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 777 AA; 90158 MW; 36F2BB081066D6E1 CRC64; MGLIRKIYIF CNIVMSVEGW APKLPEEKEM TTNYSGMSLR KVPTLAPATI TLDLSHNFLF QLQNSDFLSV SKLKALIASH NRIQQLDIKI FEFNKELRYL DLSHNRLKVV TWYSLTALRH LDLSFNDFET VPIGEEIGNM TQLETLGLSG AKIQKSDFQK IAHLYLNTVF FGLRSLSHYE EGSLPLLNTT KLHIILPMNI HFWVLLRDGL KTSRILQMTN IDGKIDVPGN DLLLIFQFVW HTSVEYFQIQ EMTFGGQVYL DNSFDYTNTV MRTVRLEHVH LRVFSIPQDT IYLLFTRMDI ENLTLSDAKM PHMLFPNSPK SFRYLNFANN ILTDELFKNP IQLPYLNTLI LKGNKLETLS LVSCFANHTA LMYLDLSQNL LQHINDENCL WPETLVHMNL SSNKFADSVF RCLPRNIQIL DLNYNNIQSV PKEITHLKSL RELNIAVNFL TDLPECSHLR KLSVLNIEMN LILSPSLEFF QSCQEVKTLN AGKNPFRCTC ELRNFIQLEK YSKGMMVGWP DSYICEYPLN LKGTLLKDVY LSELSCNTAL LIVTIVVLLL ILMMPVAVCF LRFDVPWYFR MLGQLMQTWH RARKAAQEQP RRNIQFHAFI SYSAHDSLWV KNELVPNLEK EDGSVLICLC ERNFDPGKSI TENIINCIEK SYKSIFVLSP NFVQSEWCHY ELYCHENSDH IILLLLEPIP LYCIPTHFHR LKALLEKKAY LEWPKDRRKC GLFWANLRIA ISANLTDIRE MCELQTFTEL SEESRGSAVS LIRTECV // ID H0WXK9_OTOGA Unreviewed; 574 AA. AC H0WXK9; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Interleukin 1 receptor type 1 {ECO:0000313|Ensembl:ENSOGAP00000007199}; GN Name=IL1R1 {ECO:0000313|Ensembl:ENSOGAP00000007199}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000007199, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000007199} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000007199} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAQR03110064; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03110065; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_012663397.1; XM_012807943.1. DR ProteinModelPortal; H0WXK9; -. DR STRING; 30611.ENSOGAP00000007199; -. DR Ensembl; ENSOGAT00000008052; ENSOGAP00000007199; ENSOGAG00000008049. DR CTD; 3554; -. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H0WXK9; -. DR OMA; IQDYEKM; -. DR OrthoDB; EOG091G03IT; -. DR TreeFam; TF325519; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019966; F:interleukin-1 binding; IEA:Ensembl. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR GO; GO:0005161; F:platelet-derived growth factor receptor binding; IEA:Ensembl. DR GO; GO:0002020; F:protease binding; IEA:Ensembl. DR GO; GO:2000661; P:positive regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl. DR GO; GO:2000391; P:positive regulation of neutrophil extravasation; IEA:Ensembl. DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 574 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003544108. FT TRANSMEM 339 360 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 43 111 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 112 211 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 228 324 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 384 542 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 574 AA; 66160 MW; FE80D7D8C144743C CRC64; MKVLLGLFCF IALLIFSLEA DECQEREETI NRVSSANEID VRSCPLNPDE KKGDDIIWYK NDSETPISTS QDSRIHQHKN QLWFVPAKVE DSGHYYCAVR DSSSCFKIKI SPKFVENEPN TCYNAEAMFV QKLPLEQDGN LVCPHLDFFK DENNEFPKTQ WYKNCQPLLL DNTHFGGATN QLIVKNVAEE HRGNYTCRAS YTYLGKQHSV TRVIAFVTTN EANKTLRPVI WSPANETIEV EPGSQMQLIC NVTAHPNTFV FWKWNGSEAE DVSVLEEEYH IAENPSDRRR STLITVLNIS EVESRFYLHP FICLARGAND LNVAYIQLIR PVPDFKNHVI GVFVLLTVII TCSVFIYKIF KIDIVLWYRD SCYIFLPPKA SDGKTYDAYI LYPKTLGEGS TSYSDIFVFK VLPEVLEKQC GYKLFIYGRD DYVGEDIVEV INENIKKCRR LIIILVREMS SFGWLGSSSE EQIAMYNALI QDGMKVVLLE LEKIQDYEKM PESIQFIKRK HGAIRWSGDY AEGPQSVKTR FWKSVRYHMP DQRRPSSAKH QLLSLATRPD SKERLQREAH LPLG // ID H0X9X2_OTOGA Unreviewed; 437 AA. AC H0X9X2; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 38. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSOGAP00000012392}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSOGAP00000012392}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012392, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000012392} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012392} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAQR03105600; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0X9X2; -. DR STRING; 30611.ENSOGAP00000012392; -. DR Ensembl; ENSOGAT00000013838; ENSOGAP00000012392; ENSOGAG00000013832. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H0X9X2; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50249 MW; FEC52E742A9BC580 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID H0XAA2_OTOGA Unreviewed; 573 AA. AC H0XAA2; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSOGAP00000012537}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSOGAP00000012537}; OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lorisiformes; Galagidae; Otolemur. OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000012537, ECO:0000313|Proteomes:UP000005225}; RN [1] {ECO:0000313|Ensembl:ENSOGAP00000012537} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B., RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N., RA Walker B.J., Sharpe T., Hall G.; RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby)."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSOGAP00000012537} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAQR03110040; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03110041; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03110042; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAQR03110043; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 30611.ENSOGAP00000012537; -. DR Ensembl; ENSOGAT00000014007; ENSOGAP00000012537; ENSOGAG00000014003. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H0XAA2; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000005225; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005225}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005225}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 573 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003544671. FT TRANSMEM 357 380 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 49 137 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 167 236 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 249 351 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 404 560 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 289 309 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 573 AA; 65871 MW; 80F65E48ACB3A9CC CRC64; MLYLAWLFLW LVTGERMERF NSSECYTKNL LWIPSKSEEE EFILFCDLPE LQKSHFCPER QCLPAQTSEH LPCGGSKDLS DVQWSLQLQN GDYLQDITES SPHIRQEKNS LHFSTRDMNI SGSYVCRPRN RSPQDVACCV KTVLEVKLQK NASCDNSVLH EQYLLLGSIS SIHCPSLSCQ SGVQSPEVTW YENGRLSEQR SNPLVVGEVY DYHQGMYVCD YTQSDNASVW TVRSVVQVIT IVKDTNFKPD ILDPVKDTQE VELGKPLTIS CRVRFGFERV PKYIIRWYVK DSERERDVLE CENKRIRSTL EDEVFECDVI LKKVTQSDLR KKFVCFAQNS LGNSTWSIQL KEKRGVLLLY VLLGTVVTLV GVLAVSVLLY QRWIEIVLLF RTYQSKDETL GDKKEFDAFI SYAKWSSFES ESASSVSEEY LALNLFPEVL ENKYGYTLCL LERDVAPGGV YAEDIIDVIQ KSRRGIFILS PNYINGPCVF ELQAAVNLAL ADQTLKLILI KFSSFQEPES LPYLVKKALR VLPTVTWKGL KSVPPNSRFW TEMHYHMPVK NSKGFSWNQL RII // ID H0YYR5_TAEGU Unreviewed; 808 AA. AC H0YYR5; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 54. DE SubName: Full=Toll-like receptor 4 precursor {ECO:0000313|Ensembl:ENSTGUP00000003444}; GN Name=TLR4 {ECO:0000313|Ensembl:ENSTGUP00000003444}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000003444, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Ensembl:ENSTGUP00000003444, ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000003444} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABQF01036880; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59729.ENSTGUP00000003444; -. DR Ensembl; ENSTGUT00000003478; ENSTGUP00000003444; ENSTGUG00000003342. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; H0YYR5; -. DR OMA; EDWVRNE; -. DR OrthoDB; EOG091G01RC; -. DR TreeFam; TF351113; -. DR Reactome; R-TGU-140534; Ligand-dependent caspase activation. DR Reactome; R-TGU-166016; Toll Like Receptor 4 (TLR4) Cascade. DR Reactome; R-TGU-166166; MyD88-independent TLR4 cascade. DR Reactome; R-TGU-2562578; TRIF-mediated programmed cell death. DR Reactome; R-TGU-5686938; Regulation of TLR by endogenous ligand. DR Reactome; R-TGU-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. DR Reactome; R-TGU-937041; IKK complex recruitment mediated by RIP1. DR Reactome; R-TGU-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex. DR Proteomes; UP000007754; Chromosome 17. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; IEA:Ensembl. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl. DR GO; GO:0005102; F:receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl. DR GO; GO:0014002; P:astrocyte development; IEA:Ensembl. DR GO; GO:0002322; P:B cell proliferation involved in immune response; IEA:Ensembl. DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl. DR GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032497; P:detection of lipopolysaccharide; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0050702; P:interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl. DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl. DR GO; GO:0032707; P:negative regulation of interleukin-23 production; IEA:Ensembl. DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl. DR GO; GO:0002537; P:nitric oxide production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl. DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl. DR GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl. DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl. DR GO; GO:0070430; P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; IEA:Ensembl. DR GO; GO:0070434; P:positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; IEA:Ensembl. DR GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; IEA:Ensembl. DR GO; GO:0010572; P:positive regulation of platelet activation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl. DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 9. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 615 636 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 657 796 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 808 AA; 91783 MW; A59676BBB36439EC CRC64; WDLPLLQVTP NTTFRCTGLN ISGVPDGVPN TTQNLDLSFS NLKSLGSNYF ASVPELQILD LSRCHLHTIE DNSFMDLPRL STLVLTANSL QHLGKAAFYG LTSLKKLVLV ETNRTSLSEL PIGHLHTLQE LNLGHNSITS LKLPKYFTNM TSLRLLSFSS NKITSISRGD LDALREGNRL NLTLVLSLNN IKSIEPGAFA GIHLAELALR SAFEKPTMQT ALQGLAGLQV SRLIVGEFRN IERLQDFEGR LLDGLCQVQM EEFVLICLRG FKDDTDTLFN CIGNVSTIRL VDLGLKEISQ VPVWSKVRQL ECKKCHFEDV PAQKLSLFKE LRMLRINDNR NLKTFEHKFK GLSNLEVIDL SENRLTFSSC CSPQFQNCPN LKHLNLSFNS NIRLTGDFTN VKNLLYLDLQ HTTLFGPGSY PVFLSLQRLI YLDISHTKTE VKSQCTFCGL NSLQVLKMAG NSFADNKLAN NFKNLSHLHT LDISSCKLEH VDQSTFDALS ELKELNISNN KLMTFDPVVY QPLQALRVLD FSRNQLAVLL DPAREILPDS LVLLDISQNL FDCSCVYLDF LKWVKEKQEL LQNEELMLCH TPSYVANVSL PSFDLSSCHI SAGQVASPVV VLFCVVVFLF LVYRYYFQLY YSMVLLSGCK HYAERGDTYD AFVIHSSKDQ EWVMKELVEP LEGGTPRFRL CLYYRDFLPG VPIVTNIIEE GFLSSRNVIA VISADFLQSK WCSFEFDIAQ SWQLVEGKAG LIMIVLEDVN KALLRQRLGL SRYLRRNTYL EWKNKEISKH IFWRQLIGVL LEGKNWNH // ID H0Z9P4_TAEGU Unreviewed; 669 AA. AC H0Z9P4; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSTGUP00000007297}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSTGUP00000007297}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007297, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007297, ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007297} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABQF01021356; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021357; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021358; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021359; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021360; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021361; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021362; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021363; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABQF01021365; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59729.ENSTGUP00000007297; -. DR Ensembl; ENSTGUT00000007369; ENSTGUP00000007297; ENSTGUG00000007085. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H0Z9P4; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Reactome; R-TGU-388844; Receptor-type tyrosine-protein phosphatases. DR Reactome; R-TGU-9007892; Interleukin-38 signaling. DR Proteomes; UP000007754; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 333 354 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 80 205 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 215 323 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 376 535 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 669 AA; 76987 MW; 68BDE7615DBA3A6E CRC64; ADGCTDWSVD YKKYQVLVGE PVRIKCALFY GYIRANYSLA QSAGLSLMWY KSSGPGDFEE PIAFDGTRMS KEEDSIWFRP TVVQDSGLYA CVIRNSTYCM KVSISLTVGE NDTGLCYNSK MKYFEKAELS KSKEISCPEI EDFLFPFREP EILWYKECKS KTWRSSIVFK KDTLVIREVR EDDIGNYTCE LKYGFFVVRR TTELTVTAPL TDKPPKLLHP LEXXXXXXXX XXNSTANLTC RAFFGYSGDV SPLIYWMKGE KFIEDLDDNR VWESDIRVLK EHLGEQEVSI SLILDSVEEA DLGNYSCYVE NGNGRRHASI LLHKRELMYT VELAGGLGAI LLLLVCLVTI YKCYKIEIML FYRNHFGAEE LDGDNKDYDA YLSYTKVDPD QWNQETGEEE RFALEILPDM LEKHYGYKLF IPDRDLIPTG TYIEDVARCV DQSKRLIIVM TPSYVVRRGW SIFELETRLR NMLVTGEIKV ILIECSELRG VMNYQEVEAL KHTIKLLTVI KWHGPKCNKL NSKFWKRLQY EMPFKRIEPM TNEQVLDVSE QGPFGELQTV SAISMAAATS TALATAHPDL RSTFHNTYHS QMRQKHYYRS YEYDVPPAGT LPLTSIGNQH TYCNIPMTLI NGQRPQTKTN REQNPEEAHT NSAILPLLPR ETSISSVIW // ID H0ZHV1_TAEGU Unreviewed; 547 AA. AC H0ZHV1; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSTGUP00000010167}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSTGUP00000010167}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010167, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Ensembl:ENSTGUP00000010167, ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000010167} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABQF01012916; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0ZHV1; -. DR STRING; 59729.ENSTGUP00000010167; -. DR Ensembl; ENSTGUT00000010274; ENSTGUP00000010167; ENSTGUG00000009856. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H0ZHV1; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Reactome; R-TGU-9012546; Interleukin-18 signaling. DR Proteomes; UP000007754; Chromosome 1. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 342 365 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 32 105 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 110 200 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 235 336 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 389 544 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 547 AA; 62548 MW; 9C8436B25437E9DA CRC64; LCIFSDGTDI LLSCFSGCYH VEPQIWYRAI NGEEFVLQCA LPDRDATNIY NSSLLNQHKV KWFWHQKDKE TLKDIKESSN LTFQGDALFF KPIRHSASGV YICRIWGKIP CLKIVLDVQT KTEAKCSGYD TNILYLLAGN GNSITCPGTK CYSHIKKQDV KWYKDGHQIK YRKSRPSLKL KQNEIYLNPT YDKDAGTYVC DYTLSENIIK WTVRTAVTVE VTAKNTIHPP NLLYPNGVVI LEVEVGKPLE LECRVQFGFE RVSPMRVTWI RNNEENVNEK LNQETTLSSV YPKGLKGHTL LHVATLKEVT EKDLRSSFTC FAENSVGNAT AVIRLKRKKR VLFLYVLCSA ISTLFAFVLC TVFIYQHWIE IVLMYRSYLV HNKSTEDGKE FDAFVSYAKL NSSESDSALI SEEKFALELL PDMLENKYGY KLCILERDIL PGGAYTDEVV SAIKQSRRVI IILSPAYVSG PSIFELQAAV NCALEDKGIK LVLIKFQDFK EPEALPPVLK KALRILPIIT WKSSISAAPH KKFWKYMRYH MPMKTTK // ID H0ZHW9_TAEGU Unreviewed; 507 AA. AC H0ZHW9; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTGUP00000010185}; GN Name=LOC100232380 {ECO:0000313|Ensembl:ENSTGUP00000010185}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010185, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Ensembl:ENSTGUP00000010185, ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000010185} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABQF01012916; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0ZHW9; -. DR Ensembl; ENSTGUT00000010293; ENSTGUP00000010185; ENSTGUG00000009867. DR eggNOG; ENOG410IPTT; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H0ZHW9; -. DR OMA; VQGTIKW; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000007754; Chromosome 1. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}. FT DOMAIN 1 78 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 91 171 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 185 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 503 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 507 AA; 58620 MW; 868982CB3D9C6DBE CRC64; DSVEGEALVI KCPKGNSPVK ITWHHTDTLK IIPAEEEGSR VFSVEKFLWF LPTSREDSGN YTCVTHFSSN RTKSYNVSVQ VHSYKPGECF PSPIRYPNDT GRGKIVCPTI DNYKNATIVQ WYKDCKPLQG QRYFKKEKYI YIENPRREDD GYYTCHFIYT HKGNVFNVSA TRIFISGVKY APLPPQIIFP KNNDVVETEL GASLSLRCQA RLGIKKQPLA AVRWDVDNIP VENLVFSRFH EETHFFDGHE QVYYEESILN ITEVKKEDLQ SNFTCIALNT MYNTRVTVTL QLKVQAKEVL PNVLLITGSL AVLGAIALSV ILYQSFQVDI VLLYREIFQP HSVKNDGKIY DAYVIYPKNH TSEANFVEYF VYQIMPDILE NKCGYTLCIY GRDIYPGEDA VSAIEMRLQK SRRLIILLTH QLVNSKEDAF DQHIALYNAL IQNDTKVILL EMETIGTYEK LQESLRFIIK QQGTIKWKEE HTVHPQSPSS RFWKQVRYHM PLTHRPS // ID H2P5A0_PONAB Unreviewed; 599 AA. AC H2P5A0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 41. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSPPYP00000013511}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSPPYP00000013511}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013511, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000013511, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000013511} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABGA01271348; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01271349; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01271350; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01271351; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002811757.1; XM_002811711.2. DR ProteinModelPortal; H2P5A0; -. DR STRING; 9601.ENSPPYP00000013511; -. DR Ensembl; ENSPPYT00000014060; ENSPPYP00000013511; ENSPPYG00000012113. DR GeneID; 100442977; -. DR KEGG; pon:100442977; -. DR CTD; 8807; -. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H2P5A0; -. DR KO; K05174; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000001595; Chromosome 2a. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 599 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003568057. FT TRANSMEM 359 382 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 149 235 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 251 353 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 406 562 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 599 AA; 68480 MW; BBDF9E487CD415DB CRC64; MLYLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE PQKSHFCHRN RLSPKQVPEH LPFMGSKDLS DVRWYRQPSN GDPLEDIRKS YPHIIQDKCT LRFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ TNASSENSTS HKQDLLLGST GSISCPSLSC QSDAQSPEVT WYKNGKLLSV ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK PDILDPVEGT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV SVPEAKSIKS TLKDEIIERN IILEKVTQRD LHRKFVCFVQ NSIGNTTQSV QLKEKRGVVL LYILLGTIAT LVSVLAASAL LYRYWIEIVL LYRTYQSKDE TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYTL CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL ALGDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR FWTKMRYHMP MKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW // ID H2PV69_PONAB Unreviewed; 695 AA. AC H2PV69; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSPPYP00000022613}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSPPYP00000022613}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000022613, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000022613, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000022613} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABGA01072758; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072759; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072760; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072761; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072763; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072764; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072765; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072766; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01072767; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9601.ENSPPYP00000022613; -. DR Ensembl; ENSPPYT00000023573; ENSPPYP00000022613; ENSPPYG00000020212. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H2PV69; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000001595; Chromosome X. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 695 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003567723. FT TRANSMEM 359 380 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 6 134 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 162 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 334 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 402 561 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 695 AA; 79837 MW; 8A946704E861965B CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSIDIKK YQVLVGEPVR IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPVES KLTIQETQLG DSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYENGNG RRHASVLLHK RELMYTVELA GGLGAILLLL VCLVTIYKCY KIEIMLFYRN HFGAEELDGD NKDYDAYLSY TKVDPDQWNQ ETGEEERFAL EILPDMLEKH YGYKLFIPDR DLIPTGTYIE DVARCVDQSK RLIIVMTPNY VVRRGWSIFE LETRLRNMLV TGEIKVILIE CSELRGIMNY QEVEALKHTI KLLTVIKWHG PKCNKLNSKF WKRLQYEMPF KRIEPITHEQ ALDVSEQGPF GELQTVSAIS MAAATSTALA TAHPDLRSTF HNTYHSQMRQ KHYYRSYEYD VPPTGTLPLT SIGNQHTYCN IPMTLINGQR PQTKSSREQN PDEAHTNSAI LPLLPRETSI SSVIW // ID H2PWD7_PONAB Unreviewed; 686 AA. AC H2PWD7; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=IL1RAPL2 isoform 1 {ECO:0000313|EMBL:PNJ54666.1}; DE SubName: Full=Interleukin 1 receptor accessory protein like 2 {ECO:0000313|Ensembl:ENSPPYP00000023054}; GN Name=IL1RAPL2 {ECO:0000313|Ensembl:ENSPPYP00000023054}; GN ORFNames=CR201_G0020485 {ECO:0000313|EMBL:PNJ54666.1}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000023054, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000023054, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSPPYP00000023054} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNJ54666.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Susie {ECO:0000313|EMBL:PNJ54666.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ABGA01293951; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293952; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293953; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293954; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293955; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293956; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293957; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293958; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293959; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABGA01293960; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NDHI03003425; PNJ54666.1; -; Genomic_DNA. DR RefSeq; XP_002831995.1; XM_002831949.1. DR STRING; 9601.ENSPPYP00000023054; -. DR Ensembl; ENSPPYT00000024024; ENSPPYP00000023054; ENSPPYG00000020597. DR GeneID; 100443738; -. DR KEGG; pon:100443738; -. DR CTD; 26280; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H2PWD7; -. DR KO; K05170; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000001595; Chromosome X. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004910; F:interleukin-1, Type II, blocking receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004077; IL-1_rcpt_II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01539; INTRLEUKN1R2. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001595}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 686 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003567754. FT TRANSMEM 357 378 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 132 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 160 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 239 347 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 400 559 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 686 AA; 78796 MW; 68D57992449F92F1 CRC64; MKPPFLLALL VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI RTNYSMAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKRSIKF LSLIKWKGPK SSKLNSKFWK HLVYEMPIKK KEMLSRCHVL DSAEQGLFGE LQPIPSIAMT STSATLVSSQ ADLPEFHPSD SMQMRHCCRG YKHEIPTTTL PVPSLGNHHT YCNLPLTLLN GQLPLNNTLK DTQEFHRNSS LLPLSSKELS FTSDIW // ID H2QYY8_PANTR Unreviewed; 686 AA. AC H2QYY8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=IL1RAPL2 isoform 1 {ECO:0000313|EMBL:PNI29600.1}; DE SubName: Full=Interleukin 1 receptor accessory protein like 2 {ECO:0000313|Ensembl:ENSPTRP00000038081}; GN Name=IL1RAPL2 {ECO:0000313|Ensembl:ENSPTRP00000038081, GN ECO:0000313|VGNC:VGNC:12416}; GN ORFNames=CK820_G0042038 {ECO:0000313|EMBL:PNI29600.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000038081, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000038081, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the RT human genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136134; DOI=10.1038/nature04101; RA Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T., RA Rozen S., Wilson R.K., Page D.C.; RT "Conservation of Y-linked genes during human evolution revealed by RT comparative sequencing in chimpanzee."; RL Nature 437:100-103(2005). RN [3] {ECO:0000313|Ensembl:ENSPTRP00000038081} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000313|EMBL:PNI29600.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI29600.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI29600.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AACZ04018095; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AACZ04018096; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AACZ04018097; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AACZ04018101; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AACZ04018102; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC193208; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC193542; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC193563; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC194762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC195522; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000396; PNI29600.1; -; Genomic_DNA. DR STRING; 9598.ENSPTRP00000038081; -. DR PaxDb; H2QYY8; -. DR Ensembl; ENSPTRT00000041224; ENSPTRP00000038081; ENSPTRG00000022140. DR VGNC; VGNC:12416; IL1RAPL2. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H2QYY8; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000002277; Chromosome X. DR Bgee; ENSPTRG00000022140; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004910; F:interleukin-1, Type II, blocking receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004077; IL-1_rcpt_II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01539; INTRLEUKN1R2. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002277}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 686 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003571259. FT TRANSMEM 357 378 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 132 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 160 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 239 347 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 400 559 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 686 AA; 78654 MW; 6398E6D3BB9742A5 CRC64; MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGPK SSKLNSKFWK HLVYEMPIKK KEMLPRCHVL DSAEQGLFGE LQPTPSIAMT STSATLVSSQ ADLPEFHPSD SVQMRHCCRG YKHEIPATTL PVPSLGNHHT YCNLPLTLLN GQLPLNNTLK DTQEFHRNSS LLPLSSKELS FTSDIW // ID H2SZ04_TAKRU Unreviewed; 567 AA. AC H2SZ04; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000017642}; GN Name=LOC101061911 {ECO:0000313|Ensembl:ENSTRUP00000017642}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000017642, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000017642} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000017642} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2SZ04; -. DR Ensembl; ENSTRUT00000017716; ENSTRUP00000017642; ENSTRUG00000007177. DR GeneTree; ENSGT00760000119071; -. DR OMA; ADDNKEY; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 349 371 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 4 123 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 221 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 239 345 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 396 546 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 567 AA; 65235 MW; D2B68AA4C0D0181D CRC64; ICLPSTISSL CVHTVDGCID WSVDLKEYHV LAGEPVRVKC ALFYSYIRTN YSAAANTKLR LIWYKNKGDA ELEPSVNCRI KGHRLSKEDD SLWFRSAELE DNGFYTCVLR NSTYCMKVSM SVTIEASDEG KCFSSKMRYM EKAEITHAKM MSCPDIEDYL APYKQPQMNW YKECEQIEWR KSIVANSTHV WIPEVEEGDG GNYTCELQYG SRLVRRTLLL KVTDPASPGA AASPHLQNPR FNGLYEKISG MPLSLDCKAF FGYSGENKQP IVYWMKGEKF VEELAGHIKE SEVRILKEHL GEREVQLSLI FDAVEEADLD NYTCYVENHI GRRSGSVFLR KKSLKTHMYR LELAGGLGII LLLLGVLTAF YKCYNLEIVL CYRRHFGSDE TEDDNKEYDA YLYYTMNDDE ETLALEILPD VLENQYGYKL FIPDRDLIPS STYVEDLARS VDQSRRLILV LTPDFVAKRG WSVFLIETRL HSMLVTGEIK VIMIECVDLK NVINYQEVEL LKQTIKALSV IKWKGPKSNK PTSKFWKQML YEMPAKQKEI LSKDQNSSFS HCILNSL // ID H2T5Z0_TAKRU Unreviewed; 1065 AA. AC H2T5Z0; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSTRUP00000020079}; GN Name=tlr7 {ECO:0000313|Ensembl:ENSTRUP00000020079}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000020079, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000020079} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000020079} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000020161; ENSTRUP00000020079; ENSTRUG00000008051. DR GeneTree; ENSGT00530000063201; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 856 887 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 905 1052 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1065 AA; 122550 MW; 28AE16C6151C8482 CRC64; SGSLPTDQSV NALLHHSATM SAIINALIHS LETLLANVSY PKTLPCDVTN NGSVVNVDCT ERSLKGVPVG IPRDVTNLTL TINHIPNFNS SSFQGLDNLR EIDMRCNCVP VKIGPKDRIC TESVTIEENT FTSLRNLQSL YLDGNQLYII PEGLPSSLIL LSLEVNHIYY ISKANLSEIR NIESLYLGQN CYYRNPCNFS YGIEEGAFLE LHNLKLLSLK SNNLSFIPHH LPSSLKELYL YNNNFQQVTD EDFKNLTNLE ILDISGNCPR CYNVPFPCNP CPNNSPLQIS KSAFKTLTKL KTLRMHSNSL RYVVPEWFAS TKELRVLDLS SNHLARDIGV TLFPHHLGKL QELDLSFNYE LQRYPRTLRL SCSFKSLNSL RILRLQGFVF QQLKPESITP LKSLTNLEVL DLGTNFIKMT NLSILMELKS FKIINLSNNR ISSPSDGQAA VGFSGGQAWE WSPMLPADQY QNEEVREIHY FRYDEYARSC KYKDKELGVI ASFVKRECSQ FGKTLDVSRN NIFFLHSRFL NLRELKCLNL SGNAMSQSLN GSEFTYLTGL QYLDFSSNRL DLLYSTAFQE LKNLVILDIS NNNHYFESEG LTHMLNFTQN LKNLKILMMN HNKISTSTNT ELESQSLERL EFRGNRLDML WRDGNTRYLN YFKKLSNLAV LDISHNNLNS IQQQVFSGLP DTLSELYVNN NKLKSFAWGE LSLLPSLLVL DLSGNYLTTV PHMLSNCSKS LKKLILHKNE ILKLTPDFLK YAYNLKYLDL SFNRIGQIEK SNFPDDVVNG MDMLLLHKNR FQCSCSAIWF VMWLNQTTVT IPRLATDVTC ASPGAQRGHP VISVDLLACQ HNFLSIILYF LMTSFTLIFF TLAISSHLFL WDVWYIYHFC RAKLKGYSQL SSQSSVYDAF VMYDKEDSAV SEWVMKEMCV QLEGREDRRL TLCLEERDWI PGTPVIDNLS QSIHRSKRTV FILTNTYIKS GSFKTAFYMA HQRLMDEKND VIVLIFLENI PYNSRYLRLR RRLYRRSVLE WPTNPQARPY FWFSVRSVLA TESHKQYNNL FKETL // ID H2T5Z1_TAKRU Unreviewed; 1050 AA. AC H2T5Z1; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSTRUP00000020080}; GN Name=tlr7 {ECO:0000313|Ensembl:ENSTRUP00000020080}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000020080, ECO:0000313|Proteomes:UP000005226}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000020080} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000020080} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR Ensembl; ENSTRUT00000020162; ENSTRUP00000020080; ENSTRUG00000008051. DR GeneTree; ENSGT00530000063201; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 841 872 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 890 1037 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1050 AA; 121245 MW; DD78358B9C5E20E1 CRC64; LLLFSSSIKK IKTFKKLITL TNVSYPKTLP CDVTNNGSVV NVDCTERSLK GVPVGIPRDV TNLTLTINHI PNFNSSSFQG LDNLREIDMR CNCVPVKIGP KDRICTESVT IEENTFTSLR NLQSLYLDGN QLYIIPEGLP SSLILLSLEV NHIYYISKAN LSEIRNIESL YLGQNCYYRN PCNFSYGIEE GAFLELHNLK LLSLKSNNLS FIPHHLPSSL KELYLYNNNF QQVTDEDFKN LTNLEILDIS GNCPRCYNVP FPCNPCPNNS PLQISKSAFK TLTKLKTLRM HSNSLRYVVP EWFASTKELR VLDLSSNHLA RDIGVTLFPH HLGKLQELDL SFNYELQRYP RTLRLSCSFK SLNSLRILRL QGFVFQQLKP ESITPLKSLT NLEVLDLGTN FIKMTNLSIL MELKSFKIIN LSNNRISSPS DGQAAVGFSG GQAWEWSPML PADQYQNEEV REIHYFRYDE YARSCKYKDK ELGVIASFVK RECSQFGKTL DVSRNNIFFL HSRFLNLREL KCLNLSGNAM SQSLNGSEFT YLTGLQYLDF SSNRLDLLYS TAFQELKNLV ILDISNNNHY FESEGLTHML NFTQNLKNLK ILMMNHNKIS TSTNTELESQ SLERLEFRGN RLDMLWRDGN TRYLNYFKKL SNLAVLDISH NNLNSIQQQV FSGLPDTLSE LYVNNNKLKS FAWGELSLLP SLLVLDLSGN YLTTVPHMLS NCSKSLKKLI LHKNEILKLT PDFLKYAYNL KYLDLSFNRI GQIEKSNFPD DVVNGMDMLL LHKNRFQCSC SAIWFVMWLN QTTVTIPRLA TDVTCASPGA QRGHPVISVD LLACQHNFLS IILYFLMTSF TLIFFTLAIS SHLFLWDVWY IYHFCRAKLK GYSQLSSQSS VYDAFVMYDK EDSAVSEWVM KEMCVQLEGR EDRRLTLCLE ERDWIPGTPV IDNLSQSIHR SKRTVFILTN TYIKSGSFKT AFYMAHQRLM DEKNDVIVLI FLENIPYNSR YLRLRRRLYR RSVLEWPTNP QARPYFWFSV RSVLATESHK QYNNLFKETL // ID H2UQS4_TAKRU Unreviewed; 533 AA. AC H2UQS4; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000039297}; GN Name=LOC105417746 {ECO:0000313|Ensembl:ENSTRUP00000039297}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000039297}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000039297} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000039297} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 31033.ENSTRUP00000039297; -. DR Ensembl; ENSTRUT00000039438; ENSTRUP00000039297; ENSTRUG00000015378. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H2UQS4; -. DR OMA; QKVGLHD; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}. FT DOMAIN 1 78 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 83 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 193 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 348 518 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 533 AA; 60330 MW; 05DD020253615AFF CRC64; TETYKVSVGH LFILKCRISQ TNVTWSREGT HNQSLPPGVE ARGGLLRFLP VQMEHNGSYT CQKRDETNLK MKFSVLVSRE KCPEALETRS ISQGRNGVLP CKLREIFQLN TTRIVQWMKD CHPVEREGKS ISVTEGGVMW LSEASEEDAG TYTCLVDVSL DGRNYTAARS IQLVIETGAC HQRLHLKLQV LYPQQAVVIV EVGMRAELKC SAHVGFMDDS ELSIYWTFNS EHTEAYIEER RGEERRGEES DPERRQVTES TLSISKVRRE FLNVPFRCCV VSPADKKVGL LHLQEADRRG LHITVALCLS AFLTALGLAA AFQFCRTELT LAYRNLSGHL NKPAPEGKLY DAYVSYLHRN SRSSQSALFA LQILPEKLER QHGYTLYIRG RDDSPGEAVH DAIATVIRQC QRLILILSTE EEFGTDGNEK GDLLCDQSQL CYEQSISLYD ALLLNDPKVI LVELGLVDYS GLPESLRYIR RKQGSLTWRK ASAGAPSLRK MYLNRNFWKD LRCHMPSVRM STHTYSGDSW NAG // ID H2UQS5_TAKRU Unreviewed; 485 AA. AC H2UQS5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000039298}; GN Name=LOC105417746 {ECO:0000313|Ensembl:ENSTRUP00000039298}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000039298}; RN [1] {ECO:0000313|Ensembl:ENSTRUP00000039298} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000039298} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H2UQS5; -. DR Ensembl; ENSTRUT00000039439; ENSTRUP00000039298; ENSTRUG00000015378. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}. FT DOMAIN 1 78 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 83 172 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 193 289 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 300 470 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 485 AA; 55132 MW; E70BC5C0E66059FF CRC64; TETYKVSVGH LFILKCRISQ TNVTWSREGT HNQSLPPGVE ARGGLLRFLP VQMEHNGSYT CQKRDETNLK MKFSVLVSRE KCPEALETRS ISQGRNGVLP CKLREIFQLN TTRIVQWMKD CHPVEREGKS ISVTEGGVMW LSEASEEDAG TYTCLVDVSL DGRNYTAARS IQLVIETGAC HQRLHLKLQV LYPQQAVVIV EVGMRAELKC SAHVGFMDDS ELSIYWTFNS EHTEAYIEER RGEERRGEES DPERRQVTES TLSISKVRRE FLNVPFRCCV VSPADKKVGL LHLQEAPEGK LYDAYVSYLH RNSRSSQSAL FALQILPEKL ERQHGYTLYI RGRDDSPGEA VHDAIATVIR QCQRLILILS TEEEFGTDGN EKGDLLCDQS QLCYEQSISL YDALLLNDPK VILVELGLVD YSGLPESLRY IRRKQGSLTW RKASAGAPSL RKMYLNRNFW KDLRCHMPSV RMSTHTYSGD SWNAG // ID H2ZUT7_LATCH Unreviewed; 1060 AA. AC H2ZUT7; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 46. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000001158}; GN Name=LOC102356471 {ECO:0000313|Ensembl:ENSLACP00000001158}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001158, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000001158} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000001158}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000001158} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AFYH01268383; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7897.ENSLACP00000001158; -. DR Ensembl; ENSLACT00000001169; ENSLACP00000001158; ENSLACG00000001037. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; H2ZUT7; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 900 1047 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1060 AA; 122082 MW; B206CBC11FF062C9 CRC64; RIIPLFKIFK KCTSMYWALN HLKVIIFLNA VSKVFAATWF PKTLPCDVNV TERSILLDCS ERHLTEIPKG IPANATNITL TINRIPNVFK TSFSGLEDLK EIDLRCNCMP VKIGPKDQVC TKRLHVQEGS FFSLRNLKSL YLDGNQLAEI PRGLPYNLAL LSLEVNSIYS IRSENLSELS NLESLYLGKN CYYRNPCNVS FFIENGAFSN MSNLLILSLK ADNLTCVPQI LPPSLRQLYL YNNVIQKINK MDFANLVHLE ILDLSGNCPR CYNAPFPCTP CPGQVSIQIH PSAFKELRNL RILRLHGNSL RSVTSEWFHN TPLLQVLDLS QNFLIKEIGE AKFLNYLGNL QHLDLSFNFA LQSYPTHLTL SETFSNLTSL ETLRLRGYIF KELKRENLQP LFGLRYLEVI DFGTNFIKIA NLNFIKDFPA LHIVNLSENK ISPSSSDSIC GLCSISRSSF GQYYSPGILG DMHYFIYDEY GRSCKTKDKE DESFNFFVDR ECSKYGKVLD LSRNNLFFIN PAQFQDLTFL ACLNMSGNAI SQTLNGSEFQ YLSNLKYLDF SNNRLDLLYW TAFQEMKQLE VLDLSGNSHY FLAEGLTHML NFTMGLPALK KLKMNWNEIS TSTNTKLKSL SLEVLELKGN RLDILWKDGD NRYLEFFKEL SNLTVLDISY NSISFVPPRV FENMPPNLLE LYLNNNDLKS FNWGKLHFLR KLITLDLSYN ALKTVPRELS NCTKHLQKLI LRNNKIPKLT KNFLRDAYSL RYLDLSKNKI QIIEQSSFPE KVLNNMEVLL LNGNQFLCTC DAVSFIWWIQ HTTVNIPRLA TDVICAGPGV HQGESVISVD LYACDLDSLA VILHSLSASV IIFLLVVTIS SHLFFWDVWY SYHFCAAKFK GYHPLVSQST CYDAYIAYDV KDPDVADWVF KELCVQLEEQ GDKYFNLCLE ERDWIPGHPI IDNLSQSIQL SRKTVFVLTN RYIRSGSFRV TFYMAHQRLI DEKVDVIVLV FLEKALQKSK YLKLRKRLCS SSVLDWPTNP QAQHYFWQCL KNALATDNRM QYSKLFQETL // ID H2ZUY1_LATCH Unreviewed; 935 AA. AC H2ZUY1; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 45. DE SubName: Full=Toll-like receptor 21 {ECO:0000313|Ensembl:ENSLACP00000001202}; GN Name=LOC102355483 {ECO:0000313|Ensembl:ENSLACP00000001202}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001202, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000001202} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000001202}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000001202} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AFYH01089242; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7897.ENSLACP00000001202; -. DR Ensembl; ENSLACT00000001213; ENSLACP00000001202; ENSLACG00000001078. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; H2ZUY1; -. DR OMA; WSTMSLE; -. DR OrthoDB; EOG091G02LX; -. DR TreeFam; TF351113; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl. DR GO; GO:0052033; P:pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; IEA:Ensembl. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 15. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 935 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003578740. FT TRANSMEM 727 747 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 776 922 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 935 AA; 108862 MW; 6887736DD49FFEEC CRC64; VLLLGVLGVP LVISMGFRNC IQREYDPNSY ACIQRFLKDV ASAVSDLPPS ARTVNISHNS IRRLVPASFS HLTQLVHLRL DFNRLLVIQD GAFDNLTSLR ILNLTNNNIS RLSRGTFRGL VNLTDLLLHN NKLRTVDNQA FQPLEKVRNI QLSFNNLTLF SELVESVSEL RKLQSLDLCH NNISSLNHSF EFPGSLRFLY LCYNHIRDLD CHRDLFAPIH MLDLSNNSIS SAASFRYVNL SNTGLLRLKD NPYLDVFQFL NSSDIPPQNV DYSGMLVGKQ WSIPQLCQHL GSQTMDHFSL LYNKFTDLNR SAINHCPPIK KLDLSNNNIV SLDCLRFVNN KSSLHSFIMD HNKLDSLGSC NASKVPNLRN ISLRYNCILT IEPYAFSFAP RLRTLMLNFN DIVYLKPNAL AGLRNLIVLR LDNNLLTGLY EGRFQDLENL KILNLRNNNV PTIHLKTFFK LTNLIILDLG GNRIRKLTKD SFRYLKSLKK LYLDKNHIKY IQSKIFSPIH STLQVLDLQK NNLRYNSYRI KISPFEELSQ LYDLKLQSQQ PYGINIIPLL FFKGLTSLKA LYLSQNVELS LSPDTFYDLS SLEKLYISDA YNGIQNFAPG IFKKLTRLKI LNLENTGVQL VTPEVFGDLV NLTVLYLAKN AMQTINIDVF KNLTSLRYLD LRKCPVSCTC NNQDFKEWME KSTVQIVYFY NYTCVNQNKE LFYKFDVKVC HVDFGKILFI SVFPTLLLVM TIPILYIKNY WHLKYGFYIF YSWFSDYWWQ KEDQQYLYDA FVSYNSHDEN WVLQQLLPNL ETKGPPSFKL CLHHRDFELG KNIIDNIVDS IYNSRKTICV ISRRYLFSEW CSLEIQLASY RLFQEKKDVL ILVFLEDIPK GELSKYHRMR KVMLKKTYIS WPQEEDAQDL FWARIRKALK ESNSNPEQDN IQLKD // ID H2ZXM5_LATCH Unreviewed; 553 AA. AC H2ZXM5; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000002146}; GN Name=LOC102358615 {ECO:0000313|Ensembl:ENSLACP00000002146}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002146, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000002146} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000002146}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000002146} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AFYH01136298; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136299; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136300; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136301; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136302; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_006002958.1; XM_006002896.2. DR RefSeq; XP_006002959.1; XM_006002897.2. DR RefSeq; XP_006002960.1; XM_006002898.1. DR RefSeq; XP_014348130.1; XM_014492644.1. DR RefSeq; XP_014348131.1; XM_014492645.1. DR ProteinModelPortal; H2ZXM5; -. DR STRING; 7897.ENSLACP00000002146; -. DR Ensembl; ENSLACT00000002162; ENSLACP00000002146; ENSLACG00000001917. DR GeneID; 102358615; -. DR KEGG; lcm:102358615; -. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H2ZXM5; -. DR KO; K04386; -. DR OMA; IQDYEKM; -. DR OrthoDB; EOG091G03IT; -. DR TreeFam; TF325519; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 553 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003578795. FT TRANSMEM 357 378 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 39 124 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 130 227 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 243 310 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 402 551 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 553 AA; 64083 MW; 27240E1555C63308 CRC64; MTCLLLYLTV CSIFMLNVAS TSEKDSCKDF GESFDRSYVP EGELAVLKCP IYHEFGSTCH EDTDNLDPIW YKNDSERIIP ERGSRLQTNK ESLWFFPVRQ EDSGSYTCVM RNSTDCIKQS VILFVHKADP DLCMNKHKYG VTLIKNVDEK QDEKLVCPDL GDTYWLQKMP SLQWYKECQL IETDDIKYWN VGELLIRDMT KDDEGNYTCE MNVMYEGKPF KMTRTIDIYV KEMSFAILEV IYPTNNTIEA KLGINYSIPC HVLSRSSALA EVTVFWLVNN ELVASNKNCN EEKPASYVCN VTTDLEQNLH TNQLRICEVK KKDFGKIFQC IAFGERGAVA SAYFILKPLA PSYKTCIVGT FTALSFIIMM IVLIYKIFKV DIVLWYRNSC PRLRKTEVLD GKIFDAYVIY SKHNCIAETF VMQILPHVLE KKCGYKLFIY GRDVLPGQAI AEMVDETIRR STRLIVILTP STNIKDDFES QIGMHNILIH NQIKAILIEY GKIKDYTYLP ESIQYIKEKQ GTIKWKGDNT EKSLSPNLRF WKNVRYQMPH RPF // ID H2ZXM6_LATCH Unreviewed; 529 AA. AC H2ZXM6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000002147}; GN Name=LOC102358615 {ECO:0000313|Ensembl:ENSLACP00000002147}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002147, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000002147} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000002147}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000002147} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AFYH01136298; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136299; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136300; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136301; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01136302; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSLACT00000002163; ENSLACP00000002147; ENSLACG00000001917. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 335 356 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 100 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 106 203 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 380 529 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 529 AA; 61654 MW; 0F84AE825196F66C CRC64; DSCKDFGESF DRSYVPEGEL AVLKCPIYHE FGSTCHEDTD NLDPIWYKND SERIIPERGS RLQTNKESLW FFPVRQEDSG SYTCVMRNST DCIKQSVILF VHKADPDLCM NKHKYGVTLI KNVDEKQDEK LVCPDLGDTY WLQKMPSLQW YKECQLIETD DIKYWNVGEL LIRDMTKDDE GNYTCEMNVM YEGKPFKMTR TIDIYVKAEM SFAILEVIYP TNNTIEAKLG KLSINYSIPC HVLSRSSALA EVTVFWLRNV KFVQSGHYKQ KWAYYVCNVT TDLEQNLHTN QLRICEVKKK DFGKIFQCIA FGERGAVASA YFILKPLAPS YKTCIVGTFT ALSFIIMMIV LIYKIFKVDI VLWYRNSCPR LRKTEVLDGK IFDAYVIYSK HNCIAETFVM QILPHVLEKK CGYKLFIYGR DVLPGQAIAE MVDETIRRST RLIVILTPST NIKDDFESQI GMHNILIHNQ IKAILIEYGK IKDYTYLPES IQYIKEKQGT IKWKGDNTEK SLSPNLRFWK NVRYQMPHR // ID H3A537_LATCH Unreviewed; 1033 AA. AC H3A537; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 49. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSLACP00000004758}; GN Name=LOC102347513 {ECO:0000313|Ensembl:ENSLACP00000004758}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004758, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000004758} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000004758}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000004758} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AFYH01253536; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7897.ENSLACP00000004758; -. DR Ensembl; ENSLACT00000004799; ENSLACP00000004758; ENSLACG00000004229. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; H3A537; -. DR OMA; RTICATW; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 16. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 1033 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003579234. FT TRANSMEM 824 848 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 873 1020 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1033 AA; 118812 MW; AEEA6B1BB6CBDD97 CRC64; HLSFQSRLLW CSFLLRGGSW WQCVQEKFPK TLPCDVNVTE RSILLDCSER HLTKIPKGIP ANATNITLSI NHIPNVFKTS FSGLEDLKEI DFRCNCMPVK IGPKDQICTK RLHVQEDSFR SLKSLKSLYL DGNQLSEIPR GLPPNLALLS LEVNNIYSIR SENLSELSNL ESLYLGKNCY FRNPCNVSFF IENGAFSNMS NLLILSLKAD NLTNVPQNLP PSLRQLYLYN NMIQKINKMD FANLVHLEIL DLSGNCPRCY NAPFPCTPCP GQVSIQIHPS AFKELRNLRI LRLHSNSLRS VTSEWFHNTP LLQVLELSQN FLAKEIGEAK FLNFLGKLEE LDLSFNYALQ VYATSLTLSK TFSNLTYLKT LRLRGYVFKE LKRDDLQPLF GLRYLEVIDF GTNFIKITNL NFVRDFPALR ILYLAENKIS PTSSGSMFGS CSISSPSVSH FSPGILGGVH YFKYDEYGRS CKMECSNYGK TLDLSGNNIF FINPEQFQDL TFLACLNLSG NAMSQTLNGS EFQNLPNLKF LDFSNNRLDL LHWTAFQELK KLEVLDISVN KHYFEAEGVT HMLNFTMGLP ALKKLKMNQN EISTSTNRKL KSLSLEVLEF KGNRLDILWK DGDNRYLEFF KELSNLTVLD ISYNSISFVP PPVFKNMPPN LLELYLNNNG LKSFNWGKLH FLRKLITLDL SNNALKTVPR ELSNCTKHLQ KLILRNNKIP KLTKNFLRDA YSLRYLDLSE NKIQIIEQSS FPEKVLNKME VLLLNGNQFL CTCDAVSFIW WIQHTTVNIP RLATDVICAG PGVHQGESVI SVDLNTCYLD SLALILYSLS ASVIIFLLVV TISSHLFFWD VWYSYHFCAA KFKGYHPLVS QSTCYDAYIA YDVKDPDVAD WVFKELRIQL EEQGDKYFNL CLEERDWIPG HPIIDNLSQS IQLSRKTVFV LTDRYVRSGS FKMTFYMAHQ RLIDEKLDVI VLVFLEKALQ KSKYLKLRKR LCSSSVLDWP TNPQAQRYFW QCLKNALATD NRMQYSKLFQ ETL // ID H3A6E6_LATCH Unreviewed; 437 AA. AC H3A6E6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSLACP00000005217}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSLACP00000005217}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005217, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000005217} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000005217}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000005217} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AFYH01192067; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01192068; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01192069; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01192070; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7897.ENSLACP00000005217; -. DR Ensembl; ENSLACT00000005264; ENSLACP00000005217; ENSLACG00000004635. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H3A6E6; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 95 119 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50476 MW; 9187BC949EC614F7 CRC64; GSFANLTCRA FFGYSGGITP LIYWMKEEKF IEDLDENRVR ESDIRILKEH FGEKEVSISL IIDSVEESDL GNYSCYVENG NGRRHSSILL HKRELMYTVE LAGGLGAILL LLVCLVTVYK CYKIEIMLFY RNHFGADELD GDNKDYDAYL SYTKVDPDQR SQETREEERF ALEILPDVLE KHYGYKLFIP DRDLIPSGTY IEDVARCVDQ SKRLIIVMTP NYVLRRGWSI FELETRLRNM LITGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKMDS KFWKRLQYEM PFKRIEPITN EQVLDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSLGSQHTY CNIPMTLING QRPQTKTNRE QNPEEPHTNS AILPLLPRET SISSVIW // ID H3BBS3_LATCH Unreviewed; 429 AA. AC H3BBS3; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Interleukin 1 receptor accessory protein-like 2 {ECO:0000313|Ensembl:ENSLACP00000019344}; OS Latimeria chalumnae (West Indian ocean coelacanth). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Coelacanthiformes; Coelacanthidae; Latimeria. OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000019344, ECO:0000313|Proteomes:UP000008672}; RN [1] {ECO:0000313|Ensembl:ENSLACP00000019344} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000019344}; RX PubMed=9215903; RA Zardoya R., Meyer A.; RT "The complete DNA sequence of the mitochondrial genome of a 'living RT fossil,' the coelacanth (Latimeria chalumnae)."; RL Genetics 146:995-1010(1997). RN [2] {ECO:0000313|Ensembl:ENSLACP00000019344} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AFYH01036712; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01036713; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01036714; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AFYH01036715; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7897.ENSLACP00000019344; -. DR Ensembl; ENSLACT00000019479; ENSLACP00000019344; ENSLACG00000017016. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H3BBS3; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000008672; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008672}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008672}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 100 118 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 90 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 143 302 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 429 AA; 49114 MW; 3BA1F5E657156FCC CRC64; GAPASVPCKA FFGFSGETGP MMYWMKGEKF IEELEGHIKE SEIRVLKEHL GEKEVELSLT FDTVQPTDLG NYSCYVENHN GRKHSSILLQ KRDLMYKAEL AGGLGAIILL LILIVTIYKC YNIEIMLFYR NHFGNDETED DNKEYDAYLS YTKVDPDPLE YENREEEHFA FEILPDVLEK HYGYKLFIPD RDLIPSGTYI EDLARCIEQS RRLIIVLTPD YVIRRGWSIF ELESRLHNML VTGEIKVILI ECTDLQGIVN YHEVELLKQT IKLLTVVKWI GPKCNKLSSK FWKQLVYEMP VKKKEILSRR QVLDAGEQSL FGDLKNVSSI AVTATSATLT SSQAELSDFH QTRHMQMRHY CRGYDYDVPT SPLPLTSTGN QHTYCNIPLT LLNGQLPLNS GNKDTSEIHG NSALLPLSVR ELSISSDIW // ID H3D8X6_TETNG Unreviewed; 1048 AA. AC H3D8X6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 48. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSTNIP00000016967}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000016967, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000016967} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000016967} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 99883.ENSTNIP00000016967; -. DR Ensembl; ENSTNIT00000017181; ENSTNIP00000016967; ENSTNIG00000013960. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; H3D8X6; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 17. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 1048 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003583131. FT TRANSMEM 839 870 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 888 1035 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1048 AA; 120998 MW; BC9E4DF2B3D23296 CRC64; LFLLFIILGI CCPLCILTAN VSYPKTLPCD VTNNGSVVNV DCTERSLTDV PHGIPRDVSN LTLTINHIPN FNSTSFQGLD NLREVDMRCN CVPVKIGPKD HICTKSVTIE ENTFNSLKNL QSLYLDGNQL YSIPKGLPSS LILLSLEVNH IYYISKANLS EIRNVEILYL GQNCYYRNPC NFSYGIEDGA FLELYNLKLL SLKSNNLSFI PHHLPSSLKE LYLYNNNFQS VSAEDFKNLT NLEILDISGN CPRCYNVPFP CNPCPNNAPL KISKEAFKTL TKLKTLRMHS NSLTHVAPEW FASIKELRVL DLSSNNLARD IGVTVFPNFL CKLQELDLSF NYELQKYPQT LRLSHTFESL RSLKILRLQG FVFQQLRPKS ITPLKHLTNL EVLDLGTNFI KMTNLSILME LKSFKIINLS NNKISSPSDG QEPVGLSGGQ SWEWSPMLAA DQYQNDQVRE IHYFRYDEYA RSCKYKDKEL GVIASFVKKE CSQFGKTLDV SRNNIFFLHS RFLNLRELKC LNLSGNAMSQ SLNGSEFTYL SGLQYLDFSS NRLGLLYSTA FQELKSLVIL DISYNNHYFE SEGLTHMLNF TGNLRNLKIL MMNHNKISTS TNTELESQSL ERLEFRGNRL DVMWRDGDTR YLNYFKKLSN LAILDISHNN LNSIQRQVFS GLPDTLSELY MTNNKLKSFA WEELYLLRSL LVLDLSENYL TTVPRILSNC SKSLNKLILH KNQILKLTPN FLEYAYNLKY LDLSFNHIEQ IEKSNFPDDV VNGMDVLLLH KNRFQCSCGA IWFIIWLNQT KVTIPRLATD VTCASPGAQR GHPVVSVDLS ACQHNYLSII LYILMTSFIL TFFTLSISSH LFLWDIWYIY HFCRAKLKGY NRLYSQSSVY DAFMVYDKED PAVSEWVMKE MCVQLEGRED RRLALCLEER DWIPGTPLLD NLSQSIHKSK RTVFILTSTY IKSGSFKTAF YMAHQRLMDE KNDVIVLIFL EKIPSNSKYL RLRRRLYRRS VLEWPTNPQA RPYFWFSLRS VLATESHKQY NNLFKETL // ID H3DAM7_TETNG Unreviewed; 704 AA. AC H3DAM7; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSTNIP00000017569}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSTNIP00000017569}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017569, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000017569} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017569} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR Ensembl; ENSTNIT00000017790; ENSTNIP00000017569; ENSTNIG00000014546. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 359 383 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 136 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 164 234 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 244 355 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 408 567 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 704 AA; 80965 MW; 3BB243F4A507F3E6 CRC64; QHLPLFHIAL LRRYPITVIM LQVLAKTTTL EGCTDWSVDY LKYKVLLGEP VRIKCALFYG YIRANYTHAQ SAGLSLMWYK SAGHGEFEEP ISFDGMRMSK EEDAIWFRPA ELDDAGYYSC VLRNSTYCMK VSMSLTVAEN DTDLCYNSKM RFFEKAELSK SKEITCQGIE DFIEPGAVPE IVWYKECKPK QWRQTIERRR DTLSIKEVGE DDIGNYTCEL QFGNFVVRRT TELSVTELLT GRPPKLVYTV SFQLSFRQQQ RGNSRSPVNL TCSAFFGYSG DVSPLIYWMK GDKFIEDLDE ERVQETEIKT IREHLGEQEV SISLTIESLE ESDLGNYSCY VENGNGRRQA NVQLAKKELM YTVELAGGLG AILLLLICLV TLYKCYRIEL MLFYRNHFGS EDIDGDNKDY DAYLSYTKVD PDQWSQETRE EERFALEILP DVLEKHYGYK LFIPDRDLIP TGTYIEDVAR CVDQSKRLII VMTPSYVVRR GWSIFELETR LRNMLVTGEI KVILIECAEL RGIMNYQEVE ALKHTIKMLT VIKWRGPSSN KLNSKFWKQL LYEMPFKRME PLSISHEQVL DVSEQGPFGE LQTVSAISMA AATSTAMATA QPDLRSTFHN SCHTQMRQKH YYRSYDYDLP PGGTLPPLST LGSQHTYCNI PMTLINGQRP QSKSPRQQSL DEAHGNNAML PLLPRETSIS SVIW // ID H3DAM8_TETNG Unreviewed; 706 AA. AC H3DAM8; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 40. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSTNIP00000017570}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSTNIP00000017570}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017570, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000017570} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017570} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 99883.ENSTNIP00000017570; -. DR Ensembl; ENSTNIT00000017791; ENSTNIP00000017570; ENSTNIG00000014546. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H3DAM8; -. DR OMA; ITHEQVL; -. DR TreeFam; TF333913; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 361 385 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 136 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 164 234 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 266 357 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 410 569 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 706 AA; 80971 MW; 9FB1B382B8851E27 CRC64; QHLPLFHIAL LRRYPITVIM LQVLAKTTTL EGCTDWSVDY LKYKVLLGEP VRIKCALFYG YIRANYTHAQ SAGLSLMWYK SAGHGEFEEP ISFDGMRMSK EEDAIWFRPA ELDDAGYYSC VLRNSTYCMK VSMSLTVAEN DTDLCYNSKM RFFEKAELSK SKEITCQGIE DFIEPGAVPE IVWYKECKPK QWRQTIERRR DTLSIKEVGE DDIGNYTCEL QFGNFVVRRT TELSVTAPAS EKGSQRLLPM KSFWKIKQVE IQLGGQGSPV NLTCSAFFGY SGDVSPLIYW MKGDKFIEDL DEERVQETEI KTIREHLGEQ EVSISLTIES LEESDLGNYS CYVENGNGRR QANVQLAKKE LMYTVELAGG LGAILLLLIC LVTLYKCYRI ELMLFYRNHF GSEDIDGDNK DYDAYLSYTK VDPDQWSQET REEERFALEI LPDVLEKHYG YKLFIPDRDL IPTGTYIEDV ARCVDQSKRL IIVMTPSYVV RRGWSIFELE TRLRNMLVTG EIKVILIECA ELRGIMNYQE VEALKHTIKM LTVIKWRGPS SNKLNSKFWK QLLYEMPFKR MEPLSISHEQ VLDVSEQGPF GELQTVSAIS MAAATSTAMA TAQPDLRSTF HNSCHTQMRQ KHYYRSYDYD LPPGGTLPPL STLGSQHTYC NIPMTLINGQ RPQSKSPRQQ SLDEAHGNNA MLPLLPRETS ISSVIW // ID H3DAM9_TETNG Unreviewed; 706 AA. AC H3DAM9; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSTNIP00000017571}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSTNIP00000017571}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017571, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000017571} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017571} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR Ensembl; ENSTNIT00000017792; ENSTNIP00000017571; ENSTNIG00000014546. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 361 385 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 136 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 164 234 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 266 357 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 410 569 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 706 AA; 80838 MW; 409D349C10BF9885 CRC64; QHLPLFHIAL LRRYPITVIM LQVLAKTTTL EGCTDWSVDY LKYKVLLGEP VRIKCALFYG YIRANYTHAQ SAGLSLMWYK SAGHGEFEEP ISFDGMRMSK EEDAIWFRPA ELDDAGYYSC VLRNSTYCMK VSMSLTVAEN DTDLCYNSKM RFFEKAELSK SKEITCQGIE DFIEPGAVPE IVWYKECKPK QWRQTIERRR DTLSIKEVGE DDIGNYTCEL QFGNFVVRRT TELSVTAPAS EKGSQLLRTI ESDIKVKQVE IQLGGQGSPV NLTCSAFFGY SGDVSPLIYW MKGDKFIEDL DEERVQETEI KTIREHLGEQ EVSISLTIES LEESDLGNYS CYVENGNGRR QANVQLAKKE LMYTVELAGG LGAILLLLIC LVTLYKCYRI ELMLFYRNHF GSEDIDGDNK DYDAYLSYTK VDPDQWSQET REEERFALEI LPDVLEKHYG YKLFIPDRDL IPTGTYIEDV ARCVDQSKRL IIVMTPSYVV RRGWSIFELE TRLRNMLVTG EIKVILIECA ELRGIMNYQE VEALKHTIKM LTVIKWRGPS SNKLNSKFWK QLLYEMPFKR MEPLSISHEQ VLDVSEQGPF GELQTVSAIS MAAATSTAMA TAQPDLRSTF HNSCHTQMRQ KHYYRSYDYD LPPGGTLPPL STLGSQHTYC NIPMTLINGQ RPQSKSPRQQ SLDEAHGNNA MLPLLPRETS ISSVIW // ID H3DE18_TETNG Unreviewed; 541 AA. AC H3DE18; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTNIP00000018761}; OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon OS nigroviridis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Tetraodon. OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000018761, ECO:0000313|Proteomes:UP000007303}; RN [1] {ECO:0000313|Ensembl:ENSTNIP00000018761} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496914; DOI=10.1038/nature03025; RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., RA Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., RA Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S., RA Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., RA Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., RA Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., RA Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., RA Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., RA Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., RA Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., RA Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.; RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals RT the early vertebrate proto-karyotype."; RL Nature 431:946-957(2004). RN [2] {ECO:0000313|Ensembl:ENSTNIP00000018761} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; H3DE18; -. DR STRING; 99883.ENSTNIP00000018761; -. DR Ensembl; ENSTNIT00000018989; ENSTNIP00000018761; ENSTNIG00000015686. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H3DE18; -. DR OMA; QKVGLHD; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000007303; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007303}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007303}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 541 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003582234. FT TRANSMEM 324 349 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 19 107 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 112 201 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 221 313 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 373 541 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 541 AA; 60435 MW; 9DCA177CF4EEF63F CRC64; YSFLSLIIIF TLILNISSPS HIRNTPTGTY HVSVGHLFVL KCRLGHANVS WSREGTQNQG LPAGVEARGN LLLFQPVHVS HNGSYTCEKR NSLGDFKLKM TSSVLVSRET CPEPLETKLI SLGGRVGLPC KMKEIFRLNN SRSVRWVKDC HPVEREGKAA SVTETGSVFL AEASEEDAGK YTCLVDVMLD GKSYTAARSI QLLIKNGTQD AVFTKLQVLY PQKDVVIVEP GTRAELTCLA HVGVSEDSEL SMYWTFNADH IDDYMEFNAS WRFVQNRRQV NSESTLSISK VRREFLNVPF RCHVVSPADR KIGLLYLQEA DRSVLLITVT LCLSASLISL ALAAAFLFCK PDFVLAYRNL SGIFTKPEAP DGKLYDAYVS YLHPSSGSSE AAAFALQILP EKLETRHGYS LYIRGRDDSA GEAVHDVIAT KVRQCQRVIV IMSAKEEGTG DGNTEAELLR DQSQLLYEQS ISLYDTLRLN DPKVILVEIG AVDDSGLPES LRYLKRKQGS LIWRKSSPGA SSLSKRYRNR NFWRDLRCYM P // ID H9GCP0_ANOCA Unreviewed; 550 AA. AC H9GCP0; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 28-MAR-2018, entry version 43. DE SubName: Full=Interleukin 1 receptor type 1 {ECO:0000313|Ensembl:ENSACAP00000007300}; GN Name=IL1R1 {ECO:0000313|Ensembl:ENSACAP00000007300}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007300, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000007300} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000007300}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646}; RX PubMed=21881562; DOI=10.1038/nature10390; RA Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., RA Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., RA Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., RA Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., RA Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., RA Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D., RA de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z., RA Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A., RA Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S., RA Breen M., Ponting C.P., Lindblad-Toh K.; RT "The genome of the green anole lizard and a comparative analysis with RT birds and mammals."; RL Nature 477:587-591(2011). RN [3] {ECO:0000313|Ensembl:ENSACAP00000007300} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR RefSeq; XP_008114352.1; XM_008116145.1. DR ProteinModelPortal; H9GCP0; -. DR STRING; 28377.ENSACAP00000007300; -. DR Ensembl; ENSACAT00000007456; ENSACAP00000007300; ENSACAG00000007454. DR GeneID; 100553004; -. DR KEGG; acs:100553004; -. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; H9GCP0; -. DR KO; K04386; -. DR OrthoDB; EOG091G03IT; -. DR TreeFam; TF325519; -. DR Proteomes; UP000001646; Unplaced. DR Bgee; ENSACAG00000007454; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019966; F:interleukin-1 binding; IEA:Ensembl. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR GO; GO:0005161; F:platelet-derived growth factor receptor binding; IEA:Ensembl. DR GO; GO:0002020; F:protease binding; IEA:Ensembl. DR GO; GO:2000661; P:positive regulation of interleukin-1-mediated signaling pathway; IEA:Ensembl. DR GO; GO:2000391; P:positive regulation of neutrophil extravasation; IEA:Ensembl. DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001646}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 550 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003619321. FT TRANSMEM 324 346 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 31 103 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 131 206 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 215 310 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 370 527 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 550 AA; 62993 MW; 30C6973A314E1C71 CRC64; MISALWWACW ISLTYSSLSF CVAFPTYVPV GEPYVIRCPR RSLPSNYSLT WYINGSDIPI TTNNISRIHQ RGDLLWFVPT ILEDTGSYQC VINNATKRNK DIEVVQNDDG LCFNSKTTYP QKVALSKTRQ LICPDLDDFE DKDSSLVIQW YKACSPRLLK GDRYWAFEGS FFITNVTKND EGIYICRANY TYMGKQYYVS RPINLTTYDS PPEGPIEILY PKNHSIEVEL GASISINCTA SRGLSKDVFI EWNFSGEQPE DYLSTYEKYK KKLPEKWISV IRFNISKMKA NNYGRYSCVA DSFGTDQRVA YVMLHRPAPN FQGYLIGGLV SALFVILAAL LTYKFFKVDI VLWYRESYQT AFRERVSDGK LYDAYVLYPR SITNCAYSSD IFVLKALPEV LEKQCGYKLF IFGRDDLPGQ AVVTVVDETI KRSRRVIIVL VPGSSPYGIQ EVSSEHEIAV YSALIRDGIK VILIELAKIK DYSNMAESIK YLKKKHGVLT WQGDFSAKSQ MATTRFWKNV RYQMPTNKIS PSLDLHFWPV ILNSSQISDG // ID H9JNH9_BOMMO Unreviewed; 1188 AA. AC H9JNH9; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:BGIBMGA011082-TA}; OS Bombyx mori (Silk moth). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia; OC Bombycoidea; Bombycidae; Bombycinae; Bombyx. OX NCBI_TaxID=7091 {ECO:0000313|EnsemblMetazoa:BGIBMGA011082-TA, ECO:0000313|Proteomes:UP000005204}; RN [1] {ECO:0000313|EnsemblMetazoa:BGIBMGA011082-TA} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=p50T {ECO:0000313|EnsemblMetazoa:BGIBMGA011082-TA}; RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004; RG International Silkworm Genome Consortium; RT "The genome of a lepidopteran model insect, the silkworm Bombyx RT mori."; RL Insect Biochem. Mol. Biol. 38:1036-1045(2008). RN [2] {ECO:0000313|EnsemblMetazoa:BGIBMGA011082-TA} RP IDENTIFICATION. RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:BGIBMGA011082-TA}; RG EnsemblMetazoa; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; BABH01019465; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7091.BGIBMGA011082-TA; -. DR EnsemblMetazoa; BGIBMGA011082-RA; BGIBMGA011082-TA; BGIBMGA011082. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; H9JNH9; -. DR OMA; LRGFEFD; -. DR Proteomes; UP000005204; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 6. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 22. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005204}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000005204}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 863 887 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 917 1059 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1188 AA; 135135 MW; E9C4E57293BE7498 CRC64; MSMEFHRDTF RGLTDLRSLD LGDNNIWILP SEIFCVLYNL KELNVTQNRL QDISNLGFSD WGNGPTAPGK SCNTVLETLD MSYNEISGLP DNGLSSLRAL QKLFLQNNRI SNVADRAFVG LSDLQILNLS TNALTALPPE MFQSSRDIKQ IYLNNNSLSV LAPGLLEGLD QLQILDLSVN ELTSEWINRD TFSGLVRLIV LNLSHNRITK IDALLFQDLN NLQFLSLEYN NVGRIAEGAF SNLKNLHSLS LAHNNIIEVD SGHFSNLYVL NQLFLDGNRI TKVDIRSFEN ITKLHDLGLS GNQLTDVPEA IKTLRFLTSL DLGMNKITKV ITSHFDGLDD LYGLRLVGNK IEKISKDTFA ALPSLQILNL ASNNIDQIDD GAFASNQQLK AIGLDGNKLV DLKGIFTKTQ PLVWLNVSNN ELLWFDYSHI PSNLEWLDMH ENKIDKLDDT YGLKETTMVK MLDVSNNKIK SVDELSFPSS IETVVLNNNN IEKVSPGTFL QKYNLNKVML YSNKIKTLEL GAFAISSVPD DKDLPEFYIS ENPFVCDCTM EWLQTINQVS DLRQRPRVMD LESVRCSLTH SRRKSETLLL EVKSSEFLCE YESHCFTVCH CCDFDACDCK MTCPDRCSCY HDQTWTTTNV VDCSNAGYDH VPDRIPMDAT EIYLDGNSLK ELGNHVFIGK KKLQVLYLNN SNIDIIQNRT FNGIDSLRVL HLENNNLEVL RNTQFTRLPH LNELYLSSNK IKFIENDTFN YLPSLEFLDL DNNGYVDYMP WRVISDSDPR MRVSVDGNNW ICDCKDVAQL NQWLIKKSKD TENMMCYFAH GQPMNKTIAT VAKECKTETT TEETGTETLK RLFIESNDGV ENYIPYIAAV LIIAIILLLM CALLFMFRED FKLWMHSRYG IRIFSSSPRD LNDSKNKRFD AFFVYNPRDE DFVTRAVSSE LENMGHTLCL QHRDLQLIER RSGDSLVSAA ESSKRLIIVL SINFLQQEWY APESKAAVQS AINSVNVRHR RQKIIFLVTT DLSGINIDPD LKVLLKTCTV IVWGERNCWE KLNFRLPDVD VTLPNRTLHN AYNIIKSGNR EGFGRHGNLR YTAPPTSHDP WYKYGMAPPI LMMSSPLHST SASAEVSARS TEDETCSVAS SEGRPDDRLP HHHSYVSIDN HQCEERPLRP GQQIPMSSTA HTRKTYFV // ID I18RA_MOUSE Reviewed; 614 AA. AC Q9Z2B1; DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 28-FEB-2018, entry version 133. DE RecName: Full=Interleukin-18 receptor accessory protein; DE Short=IL-18 receptor accessory protein; DE Short=IL-18RAcP; DE AltName: Full=Accessory protein-like; DE Short=AcPL; DE AltName: Full=CD218 antigen-like family member B; DE AltName: Full=IL-1R accessory protein-like; DE Short=IL-1RAcPL; DE AltName: Full=Interleukin-18 receptor accessory protein-like; DE AltName: Full=Interleukin-18 receptor beta; DE Short=IL-18R-beta; DE Short=IL-18Rbeta; DE AltName: CD_antigen=CD218b; DE Flags: Precursor; GN Name=Il18rap; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. RX PubMed=9792649; DOI=10.1074/jbc.273.45.29445; RA Born T.L., Thomassen E., Bird T.A., Sims J.E.; RT "Cloning of a novel receptor subunit, AcPL, required for interleukin- RT 18 signaling."; RL J. Biol. Chem. 273:29445-29450(1998). RN [2] RP FUNCTION. RX PubMed=11046021; DOI=10.4049/jimmunol.165.9.4950; RA Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., RA Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.; RT "IL-18 receptors, their role in ligand binding and function: anti-IL- RT 1RAcPL antibody, a potent antagonist of IL-18."; RL J. Immunol. 165:4950-4956(2000). RN [3] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=15843532; DOI=10.4049/jimmunol.174.9.5351; RA Cheung H., Chen N.-J., Cao Z., Ono N., Ohashi P.S., Yeh W.-C.; RT "Accessory protein-like is essential for IL-18-mediated signaling."; RL J. Immunol. 174:5351-5357(2005). CC -!- FUNCTION: Within the IL18 receptor complex, does not mediate IL18- CC binding, but involved in IL18-dependent signal transduction, CC leading to NF-kappa-B and JNK activation. CC {ECO:0000269|PubMed:11046021, ECO:0000269|PubMed:15843532, CC ECO:0000269|PubMed:9792649}. CC -!- SUBUNIT: Heterodimer with IL18R1; within this complex, IL18R1 is CC involved in ligand-binding and IL18RAP in signaling leading to NF- CC kappa-B and JNK activation. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass CC type I membrane protein {ECO:0000305}. CC -!- DISRUPTION PHENOTYPE: Impaired IL-18 signaling. CC {ECO:0000269|PubMed:15843532}. CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF077347; AAC72197.1; -; mRNA. DR CCDS; CCDS14912.1; -. DR RefSeq; NP_034683.1; NM_010553.4. DR UniGene; Mm.20466; -. DR UniGene; Mm.392521; -. DR ProteinModelPortal; Q9Z2B1; -. DR SMR; Q9Z2B1; -. DR STRING; 10090.ENSMUSP00000027237; -. DR iPTMnet; Q9Z2B1; -. DR PhosphoSitePlus; Q9Z2B1; -. DR EPD; Q9Z2B1; -. DR PaxDb; Q9Z2B1; -. DR PRIDE; Q9Z2B1; -. DR Ensembl; ENSMUST00000027237; ENSMUSP00000027237; ENSMUSG00000026068. DR GeneID; 16174; -. DR KEGG; mmu:16174; -. DR UCSC; uc007auk.2; mouse. DR CTD; 8807; -. DR MGI; MGI:1338888; Il18rap. DR eggNOG; ENOG410IGUG; Eukaryota. DR eggNOG; ENOG410Y9SN; LUCA. DR GeneTree; ENSGT00760000119071; -. DR HOGENOM; HOG000060101; -. DR HOVERGEN; HBG081778; -. DR InParanoid; Q9Z2B1; -. DR KO; K05174; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR PhylomeDB; Q9Z2B1; -. DR TreeFam; TF325519; -. DR Reactome; R-MMU-9012546; Interleukin-18 signaling. DR PRO; PR:Q9Z2B1; -. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000026068; -. DR CleanEx; MM_IL18RAP; -. DR ExpressionAtlas; Q9Z2B1; baseline and differential. DR Genevisible; Q9Z2B1; MM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0008283; P:cell proliferation; IMP:MGI. DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl. DR GO; GO:0071351; P:cellular response to interleukin-18; IMP:MGI. DR GO; GO:0032609; P:interferon-gamma production; IMP:MGI. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IMP:MGI. DR GO; GO:0032635; P:interleukin-6 production; IMP:MGI. DR GO; GO:0042119; P:neutrophil activation; IMP:MGI. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IMP:MGI. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IMP:MGI. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 19 {ECO:0000255}. FT CHAIN 20 614 Interleukin-18 receptor accessory FT protein. FT /FTId=PRO_0000042186. FT TOPO_DOM 20 356 Extracellular. {ECO:0000255}. FT TRANSMEM 357 377 Helical. {ECO:0000255}. FT TOPO_DOM 378 614 Cytoplasmic. {ECO:0000255}. FT DOMAIN 148 234 Ig-like C2-type 1. FT DOMAIN 250 352 Ig-like C2-type 2. FT DOMAIN 405 561 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 21 21 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 151 151 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 227 227 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 344 344 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 179 220 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 272 336 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 614 AA; 70094 MW; B71D005E4FA99BA1 CRC64; MLCLGWVFLW FVAGEKTTGF NHSACATKKL LWTYSARGAE NFVLFCDLQE LQEQKFSHAS QLSPTQSPAH KPCSGSQKDL SDVQWYMQPR SGSPLEEISR NSPHMQSEGM LHILAPQTNS IWSYICRPRI RSPQDMACCI KTVLEVKPQR NVSCGNTAQD EQVLLLGSTG SIHCPSLSCQ SDVQSPEMTW YKDGRLLPEH KKNPIEMADI YVFNQGLYVC DYTQSDNVSS WTVRAVVKVR TIGKDINVKP EILDPITDTL DVELGKPLTL PCRVQFGFQR LSKPVIKWYV KESTQEWEMS VFEEKRIQST FKNEVIERTI FLREVTQRDL SRKFVCFAQN SIGNTTRTIR LRKKEEVVFV YILLGTALML VGVLVAAAFL YWYWIEVVLL CRTYKNKDET LGDKKEFDAF VSYSNWSSPE TDAVGSLSEE HLALNLFPEV LEDTYGYRLC LLDRDVTPGG VYADDIVSII KKSRRGIFIL SPSYLNGPRV FELQAAVNLA LVDQTLKLIL IKFCSFQEPE SLPYLVKKAL RVLPTVTWKG LKSVHASSRF WTQIRYHMPV KNSNRFMFNG LRIFLKGFSP EKDLVTQKPL EGMPKSGNDH GAQNLLLYSD QKRC // ID I3KXY5_ORENI Unreviewed; 1055 AA. AC I3KXY5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 28-MAR-2018, entry version 48. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSONIP00000025981}; GN Name=tlr7 {ECO:0000313|Ensembl:ENSONIP00000025981}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025981, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000025981} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Broad Institute Genome Assembly Team; RG Broad Institute Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia)."; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSONIP00000025981} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [3] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AERX01037242; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 8128.ENSONIP00000025981; -. DR Ensembl; ENSONIT00000026002; ENSONIP00000025981; ENSONIG00000020676. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; I3KXY5; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR TreeFam; TF325595; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 1055 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003675132. FT TRANSMEM 843 871 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 895 1042 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1055 AA; 121669 MW; AD45ED3730B8A93E CRC64; LSHFSVQMCV ALLTLWSCLP ILATGIYYPK TLPCDVNEIN NGSEVRVDCT ERNLKKIPHG IPRDTTNLTL TINHIPSLNS TSFHGLENLT EIDMRCNCVP IKIGPKDKMC LKSVTIEENT FSRLSNLRAL YLDGNQLYSI PKGLPSNLIL LSLEVNHIYY LSKANLSELR NVEVLYLGQN CYFRNPCNDS YDIEDDAFLQ FNNLKLLSLK SNNLSFIPHQ LPTTLKELYL YNNNIQEVTD EDFKNLTNLE ILDISGNCPR CYNAPFPCSP CPNNAPLKIS KTAFKMLTKL KTLRLHSNSL TSVPSEWFDT TTELRVLDLS SNFLARELEI TAFPKFLGKL EELDLSFNYE LQKYPQTLRL SCSFSSLKSL KIFRMKGFVF QQLTTESIAH LKPLPNLEVV DLGTNFIKMT KLSILMELKS FKIISLSDNK ISSPSDGRDA LGLSGGETSD WSPMSSAAEY QNKEVREIHY FRYDEYARSC KYKDKELGVI TSFVKKECSQ FGKTLDVSRN NIFFLHSRFL NLTELRCLNL SGNAMSQSLN GSEFTYLANL QYLDFSWNRL DLLYSTAFQE LKNLVILDIS NNNHYFESEG LTHMLNFTRN LKNLKVLLMN HNKISTSTNT ELESQSLERL EFRDNRLDVL WRDGNTRYVN YFKNLVNLTV LDISHNNLPF IPSDVFSGLP EKLSELYIKN NKLKSFNWNK LQLLHSLRVL DLSGNSLTTV PHVLSNCTTS LEKLILHKNQ ILKLTPDFLK GAYHLKYLDL SFNHIQYIEK SSLPDDVLNH MDMLLLHKNR FLCTCNATWF VTWLNRTTVT IPKLGTDVTC VAPGAQRGRP VVSVDLLACQ HHYLSIILST LMTSLVLILV TLSISSHLFL WDVWYIYHFC RAKLKGYRRL YSQSAVYDAF VIYDKEDPAV SEWVTKEMCA HLEECGDRRL TLCLEDRDWM PGCPLIDNLS QSIHRSKRTV FILTKKYIKG GNFKTAFYMA HQRLMDEKND VIVLIFLEKV PCNSKYLRLR KRLYKRSVLE WPTNPQAQPY FWFSLRSVLA TEGHKQYNNL FKETL // ID I3LD75_PIG Unreviewed; 410 AA. AC I3LD75; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000022004}; GN Name=SIGIRR {ECO:0000313|Ensembl:ENSSSCP00000022004}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000022004, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000022004, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000022004}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000022004} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000006; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003354461.1; XM_003354413.3. DR RefSeq; XP_005655093.1; XM_005655036.2. DR RefSeq; XP_005655094.1; XM_005655037.2. DR RefSeq; XP_005655095.1; XM_005655038.2. DR RefSeq; XP_005655097.1; XM_005655040.2. DR ProteinModelPortal; I3LD75; -. DR STRING; 9823.ENSSSCP00000022004; -. DR PaxDb; I3LD75; -. DR Ensembl; ENSSSCT00000025225; ENSSSCP00000022004; ENSSSCG00000024389. DR eggNOG; ENOG410IEXB; Eukaryota. DR eggNOG; ENOG410ZFDI; LUCA. DR GeneTree; ENSGT00840000129987; -. DR InParanoid; I3LD75; -. DR OMA; EVEMNDG; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000008227; Chromosome 2. DR Bgee; ENSSSCG00000024389; -. DR Genevisible; I3LD75; SS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006953; P:acute-phase response; IEA:Ensembl. DR GO; GO:0045079; P:negative regulation of chemokine biosynthetic process; IEA:Ensembl. DR GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0043433; P:negative regulation of DNA binding transcription factor activity; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 115 140 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 14 116 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 163 310 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 410 AA; 45323 MW; 7D7051FF0092FBCD CRC64; MAGVCDRALD FLSPSGNQVL GPALGSAVTL NCTASVVSGP HCPLPSVQWL KDGLPLGNGS HHDLHEDSWV KANWSEVLVS SVLGVNLTST EDFGTFTCSI QNVSSSSFIL RRAGLAGHVA TVLASVMVLL ALLLAALLYV KCRLNVLLWY QDKYGEVEMN DGKLYDAYVS YSDSPEDRKF VNFILKPQLE RRRGYKLFLD DRDLLPRAEP SADLLVNLSR CRRLVVVLSD AFLGRAWCSH SFREGLCRLL ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW KELQLALPRK VQYRAMEGDP QTRLQDDKDP MLIVGGRGPE GRTLDPELDP DPEGDLGVRG PVFGEPAVPS HASGVSLGEG RGSEVDVSDL GSRNYSARTD FYCLVSEDDV // ID I3M3P7_ICTTR Unreviewed; 315 AA. AC I3M3P7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 35. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSSTOP00000003731}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSSTOP00000003731}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003731, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000003731} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000003731} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGTP01098090; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01098091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSTOT00000004157; ENSSTOP00000003731; ENSSTOG00000004162. DR eggNOG; ENOG410IPTT; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 2. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 2. DR SUPFAM; SSF48726; SSF48726; 3. DR PROSITE; PS50835; IG_LIKE; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}. FT DOMAIN 20 111 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 122 205 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 315 AA; 35879 MW; B02213379D13B7F2 CRC64; LPWVDKQRLG LWILAILTVP IHFIEANGYK TFWGLENEAL IVRCPKRRAP LSTVEWYYSK TNETIPTQNK NRVFASGERL KFLPASVDDS GIYTCIIRSS TLNKTGFANV TIYKKQPDCK IPDYLMYSTV SGSEKNSRIS CPTIDLYNWT APLEWFKNCE ALQGSRYRTH KSFLLINNVR SDDEGDYTCK FIHTENGVNY SVTATRSFTV TRKTANITCS ACFGKGSQFL AAVLWQINKT KVSDLGEARI QEEEGQNESF SNELICRSTV LRITDVKKED LSLEYNCLAL NLHGIIRNTI RLRRKKPSKE CGSGH // ID I3MR86_ICTTR Unreviewed; 437 AA. AC I3MR86; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 37. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000014570}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014570, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000014570} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000014570} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGTP01057021; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01057022; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01057023; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01057024; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 43179.ENSSTOP00000014570; -. DR Ensembl; ENSSTOT00000016273; ENSSTOP00000014570; ENSSTOG00000016269. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; I3MR86; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50247 MW; 04B0A976C115D202 CRC64; GDLANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LATGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID I3MZV7_ICTTR Unreviewed; 840 AA. AC I3MZV7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 52. DE SubName: Full=Toll like receptor 4 {ECO:0000313|Ensembl:ENSSTOP00000017653}; GN Name=TLR4 {ECO:0000313|Ensembl:ENSSTOP00000017653}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017653, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000017653} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017653} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGTP01019644; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01019645; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01019646; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005320949.1; XM_005320892.2. DR ProteinModelPortal; I3MZV7; -. DR STRING; 43179.ENSSTOP00000017653; -. DR Ensembl; ENSSTOT00000024441; ENSSTOP00000017653; ENSSTOG00000021892. DR GeneID; 101955169; -. DR CTD; 7099; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; I3MZV7; -. DR OrthoDB; EOG091G01RC; -. DR TreeFam; TF351113; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; IEA:Ensembl. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl. DR GO; GO:0005102; F:receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl. DR GO; GO:0014002; P:astrocyte development; IEA:Ensembl. DR GO; GO:0002322; P:B cell proliferation involved in immune response; IEA:Ensembl. DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl. DR GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032497; P:detection of lipopolysaccharide; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0050702; P:interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl. DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl. DR GO; GO:0032707; P:negative regulation of interleukin-23 production; IEA:Ensembl. DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl. DR GO; GO:0002537; P:nitric oxide production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl. DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl. DR GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl. DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl. DR GO; GO:0070430; P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; IEA:Ensembl. DR GO; GO:0070434; P:positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; IEA:Ensembl. DR GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; IEA:Ensembl. DR GO; GO:0010572; P:positive regulation of platelet activation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl. DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF13516; LRR_6; 2. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 12. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. SQ SEQUENCE 840 AA; 95588 MW; 586FA03682A4D1CD CRC64; MIPPRSLAGT LIPAMAFLSC LRPESWEPCV EVEPNVTYQC MELNLSKIPN SIPSSAKNLD LSFNPLKCID SHSFSSFPEL EVLDLSRCEI QTIEDDAYEG LHNLSTLILT GNPIQSLGTG AFHGLSSLRT LVAVETKLAS LGNFPIEHLT SLEKLNVAHN LIHSFKLPEY FSNLPNLKHL DLSSNEIQNI FNMDLEALHK MPLLNLSLDL SLNPIDFIQP GAFKEIRLHE LTLRSNFHNK SAMKTCIQGL AGLEVHRLVL GEFKNERNVE MVDKSVLEEL CNLTIEEFQL AYIDNLARDV TDLLSCLANV SAMSLVSLNL NRVEEISTGF NWQSLELVKC QFKQFPKIVL PSLKRFTCIA NKDLDSFGEL KAPRLEHLDL SGNDLSFKSC CSHYHFGTTS LKYLDLSFNG AITMTANFMG LEQLEYLDFQ YSTLNRINEF SVFLSLSKLH YLDISYTKIQ VAFHGIFNGL VSLQILKMAG NSFEDNLLPD IFTNMRNLTY LDLSKCQLEQ VSEKAFDALP ELKFLNMSHN NLFLLDELAY KPLYSLEILD CSFNSIKSSR GQELQHFPSN LTINLTQNVL ACTCEHQHFL QWIKDQRRSL VEVEKLVCAT PSDLQGLPAL SFRNDTCQIK KTIIGVSVLS ALVVSVIVFL VYKFYFHLML FAGCKKYGRG ESTYDAFVIY SSQDEDWVRN ELVKNLEEGV PPFQLCLHYR DFIPGVAIAA NIIQEGFHKS RKVIVVVSQH FIQSRWCIFE YEIAQTWQFL SSHAGIIFIV LQKVEKSLLR KQVELYRLLS RNTYLEWEDS ILGRHIFWRR LRKALMDGKL WSPEATADAG NNQQEATTCI // ID I3N7N5_ICTTR Unreviewed; 554 AA. AC I3N7N5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 35. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSSTOP00000020381}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSSTOP00000020381}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020381, ECO:0000313|Proteomes:UP000005215}; RN [1] {ECO:0000313|Ensembl:ENSSTOP00000020381} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.; RT "The Draft Genome of Spermophilus tridecemlineatus."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020381} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGTP01098090; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTP01098091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSSTOT00000030122; ENSSTOP00000020381; ENSSTOG00000004162. DR eggNOG; ENOG410IPTT; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR Proteomes; UP000005215; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0002113; F:interleukin-33 binding; IEA:Ensembl. DR GO; GO:0002114; F:interleukin-33 receptor activity; IEA:Ensembl. DR GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IEA:Ensembl. DR GO; GO:0090197; P:positive regulation of chemokine secretion; IEA:Ensembl. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005215}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005215}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 554 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5013402279. FT TRANSMEM 326 358 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 12 103 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 114 197 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 372 535 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 554 AA; 63090 MW; 7F0639472AE3DCBE CRC64; LGLWILAILT VPIHFIEANG YKTFWGLENE ALIVRCPKRR APLSTVEWYY SKTNETIPTQ NKNRVFASGE RLKFLPASVD DSGIYTCIIR SSTLNKTGFA NVTIYKKQPD CKIPDYLMYS TVSGSEKNSR ISCPTIDLYN WTAPLEWFKN CEALQGSRYR THKSFLLINN VRSDDEGDYT CKFIHTENGV NYSVTATRSF TVSACGTSVL VTWPPLPHGL SVAIRKTANI TCSACFGKGS QFLAAVLWQI NKTKVSDLGE ARIQEEEGQN ESFSNELICR STVLRITDVK KEDLSLEYNC LALNLHGIIR NTIRLRRKKP IDHQHIYYVV AGCSISLMII NILVIILKLF WIEVVLLWRD VARPYKTRND GKLYDAYVIY PRDYRCNSEE ACSAEYFVHQ ILPDVLENQC GYKLCIYGRD LLPGEDAATT VETNLRKSRR HMFILAPHIT NSQEFSYEQE IALHSALIRN DSKVILIEME PPGETGGLQV DDLQDSLKHL VKVQGTIKWR EDHVANKRSP NSRFWKHVRY QMPIPSKLPS KTCTTGTSTS VDLS // ID IRPL1_HUMAN Reviewed; 696 AA. AC Q9NZN1; A0AVG4; Q9UJ53; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 2. DT 28-FEB-2018, entry version 157. DE RecName: Full=Interleukin-1 receptor accessory protein-like 1; DE Short=IL-1-RAPL-1; DE Short=IL-1RAPL-1; DE Short=IL1RAPL-1; DE AltName: Full=Oligophrenin-4; DE AltName: Full=Three immunoglobulin domain-containing IL-1 receptor-related 2; DE Short=TIGIRR-2; DE AltName: Full=X-linked interleukin-1 receptor accessory protein-like 1; DE Flags: Precursor; GN Name=IL1RAPL1; Synonyms=OPHN4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], INVOLVEMENT IN NONSPECIFIC XLMR, TISSUE RP SPECIFICITY, AND ALTERNATIVE SPLICING. RC TISSUE=Fetal brain; RX PubMed=10471494; DOI=10.1038/12623; RA Carrie A., Jun L., Bienvenu T., Vinet M.-C., McDonell N., Couvert P., RA Zemni R., Cardona A., Van Buggenhout G., Frints S., Hamel B.C.J., RA Moraine C., Ropers H.-H., Strom T., Howell G.R., Whittaker A., RA Ross M.T., Kahn A., Fryns J.-P., Beldjord C., Marynen P., Chelly J.; RT "A new member of the IL-1 receptor family highly expressed in RT hippocampus and involved in X-linked mental retardation."; RL Nat. Genet. 23:25-31(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND INVOLVEMENT IN MRX21. RX PubMed=10757639; DOI=10.1038/sj.ejhg.5200415; RA Jin H., Gardner R.J., Viswesvaraiah R., Muntoni F., Roberts R.G.; RT "Two novel members of the interleukin-1 receptor gene family, one RT deleted in Xp22.3-Xp21.3 mental retardation."; RL Eur. J. Hum. Genet. 8:87-94(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Brain, and Testis; RX PubMed=10882729; DOI=10.1074/jbc.M004077200; RA Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., RA Sims J.E.; RT "Identification and characterization of two members of a novel class RT of the interleukin-1 receptor (IL-1R) family. Delineation of a new RT class of IL-1R-related proteins based on signaling."; RL J. Biol. Chem. 275:29946-29954(2000). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=12777533; DOI=10.1093/molbev/msg134; RA Kitano T., Schwarz C., Nickel B., Paeaebo S.; RT "Gene diversity patterns at 10 X-chromosomal loci in humans and RT chimpanzees."; RL Mol. Biol. Evol. 20:1281-1289(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., RA Williams G., Williams L., Williamson A., Williamson H., Wilming L., RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH NCS1. RX PubMed=12783849; DOI=10.1093/hmg/ddg147; RA Bahi N., Friocourt G., Carrie A., Graham M.E., Weiss J.L., Chafey P., RA Fauchereau F., Burgoyne R.D., Chelly J.; RT "IL1 receptor accessory protein like, a protein involved in X-linked RT mental retardation, interacts with Neuronal Calcium Sensor-1 and RT regulates exocytosis."; RL Hum. Mol. Genet. 12:1415-1425(2003). RN [9] RP INVOLVEMENT IN MRX21. RX PubMed=16470793; DOI=10.1002/ajmg.a.31107; RA Tabolacci E., Pomponi M.G., Pietrobono R., Terracciano A., RA Chiurazzi P., Neri G.; RT "A truncating mutation in the IL1RAPL1 gene is responsible for X- RT linked mental retardation in the MRX21 family."; RL Am. J. Med. Genet. A 140:482-487(2006). RN [10] RP VARIANTS ARG-379; HIS-618; SER-637 AND VAL-643. RX PubMed=18801879; DOI=10.1093/hmg/ddn300; RA Piton A., Michaud J.L., Peng H., Aradhya S., Gauthier J., Mottron L., RA Champagne N., Lafreniere R.G., Hamdan F.F., Joober R., Fombonne E., RA Marineau C., Cossette P., Dube M.P., Haghighi P., Drapeau P., RA Barker P.A., Carbonetto S., Rouleau G.A.; RT "Mutations in the calcium-related gene IL1RAPL1 are associated with RT autism."; RL Hum. Mol. Genet. 17:3965-3974(2008). RN [11] RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 403-561, FUNCTION, AND RP DIMERIZATION. RX PubMed=15123616; DOI=10.1074/jbc.M403434200; RA Khan J.A., Brint E.K., O'Neill L.A.J., Tong L.; RT "Crystal structure of the Toll/interleukin-1 receptor domain of human RT IL-1RAPL."; RL J. Biol. Chem. 279:31664-31670(2004). CC -!- FUNCTION: May regulate secretion and presynaptic differentiation CC through inhibition of the activity of N-type voltage-gated calcium CC channel (PubMed:12783849). May activate the MAP kinase JNK CC (PubMed:15123616). Plays a role in neurite outgrowth (By CC similarity). During dendritic spine formation can bidirectionally CC induce pre- and post-synaptic differentiation of neurons by trans- CC synaptically binding to PTPRD (By similarity). CC {ECO:0000250|UniProtKB:P59823, ECO:0000250|UniProtKB:P59824, CC ECO:0000269|PubMed:12783849, ECO:0000269|PubMed:15123616}. CC -!- SUBUNIT: Homodimer (PubMed:15123616). Interacts (calcium- CC independent) with NCS1 (PubMed:12783849). Interacts (via the first CC immunoglobilin domain) with PTPRD (via the second immunoglobilin CC domain); this interaction is PTPRD-splicing-dependent and induces CC pre- and post-synaptic differentiation of neurons and is required CC for IL1RAPL1-mediated synapse formation (By similarity). CC {ECO:0000250|UniProtKB:P59823, ECO:0000269|PubMed:12783849, CC ECO:0000269|PubMed:15123616}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12783849}; CC Single-pass type I membrane protein {ECO:0000269|PubMed:12783849}. CC Cytoplasm {ECO:0000269|PubMed:12783849}. Cell projection, axon CC {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=May CC localize to the cell body and growth cones of dendrite-like CC processes. {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=1; CC Comment=A number of isoforms are produced.; CC Name=1; CC IsoId=Q9NZN1-1; Sequence=Displayed; CC -!- TISSUE SPECIFICITY: Detected at low levels in heart, skeletal CC muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, CC hippocampus, substantia nigra and thalamus. Detected at very low CC levels in tonsil, prostate, testis, small intestine, placenta, CC colon and fetal liver. {ECO:0000269|PubMed:10471494, CC ECO:0000269|PubMed:10882729}. CC -!- DISEASE: Mental retardation, X-linked 21 (MRX21) [MIM:300143]: A CC disorder characterized by significantly below average general CC intellectual functioning associated with impairments in adaptive CC behavior and manifested during the developmental period. CC Intellectual deficiency is the only primary symptom of non- CC syndromic X-linked mental retardation, while syndromic mental CC retardation presents with associated physical, neurological and/or CC psychiatric manifestations. {ECO:0000269|PubMed:10757639, CC ECO:0000269|PubMed:16470793}. Note=The disease is caused by CC mutations affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AJ243874; CAB56046.1; -; mRNA. DR EMBL; AF181284; AAF59411.1; -; mRNA. DR EMBL; AF284435; AAG21369.1; -; mRNA. DR EMBL; AB102650; BAC81119.1; -; mRNA. DR EMBL; AL031575; CAI42035.1; -; Genomic_DNA. DR EMBL; AC005748; CAI42035.1; JOINED; Genomic_DNA. DR EMBL; AC121343; CAI42035.1; JOINED; Genomic_DNA. DR EMBL; AC129852; CAI42035.1; JOINED; Genomic_DNA. DR EMBL; AL031466; CAI42035.1; JOINED; Genomic_DNA. DR EMBL; AL031466; CAI42992.1; -; Genomic_DNA. DR EMBL; AC005748; CAI42992.1; JOINED; Genomic_DNA. DR EMBL; AC121343; CAI42992.1; JOINED; Genomic_DNA. DR EMBL; AC129852; CAI42992.1; JOINED; Genomic_DNA. DR EMBL; AL031575; CAI42992.1; JOINED; Genomic_DNA. DR EMBL; CH471074; EAW99046.1; -; Genomic_DNA. DR EMBL; BC126345; AAI26346.1; -; mRNA. DR EMBL; BC126347; AAI26348.1; -; mRNA. DR CCDS; CCDS14218.1; -. [Q9NZN1-1] DR RefSeq; NP_055086.1; NM_014271.3. [Q9NZN1-1] DR RefSeq; XP_016884729.1; XM_017029240.1. [Q9NZN1-1] DR UniGene; Hs.658912; -. DR PDB; 1T3G; X-ray; 2.30 A; A/B=403-561. DR PDB; 4M92; X-ray; 1.60 A; B=207-222. DR PDB; 5WY8; X-ray; 3.07 A; B=27-349. DR PDBsum; 1T3G; -. DR PDBsum; 4M92; -. DR PDBsum; 5WY8; -. DR ProteinModelPortal; Q9NZN1; -. DR SMR; Q9NZN1; -. DR BioGrid; 116313; 2. DR IntAct; Q9NZN1; 1. DR STRING; 9606.ENSP00000305200; -. DR iPTMnet; Q9NZN1; -. DR PhosphoSitePlus; Q9NZN1; -. DR BioMuta; IL1RAPL1; -. DR DMDM; 34222654; -. DR PaxDb; Q9NZN1; -. DR PeptideAtlas; Q9NZN1; -. DR PRIDE; Q9NZN1; -. DR DNASU; 11141; -. DR Ensembl; ENST00000378993; ENSP00000368278; ENSG00000169306. [Q9NZN1-1] DR GeneID; 11141; -. DR KEGG; hsa:11141; -. DR CTD; 11141; -. DR DisGeNET; 11141; -. DR EuPathDB; HostDB:ENSG00000169306.9; -. DR GeneCards; IL1RAPL1; -. DR HGNC; HGNC:5996; IL1RAPL1. DR MalaCards; IL1RAPL1; -. DR MIM; 300143; phenotype. DR MIM; 300206; gene. DR neXtProt; NX_Q9NZN1; -. DR OpenTargets; ENSG00000169306; -. DR Orphanet; 777; X-linked non-syndromic intellectual disability. DR PharmGKB; PA29812; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR HOGENOM; HOG000092977; -. DR HOVERGEN; HBG052148; -. DR InParanoid; Q9NZN1; -. DR KO; K05170; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR PhylomeDB; Q9NZN1; -. DR TreeFam; TF333913; -. DR Reactome; R-HSA-388844; Receptor-type tyrosine-protein phosphatases. DR Reactome; R-HSA-9007892; Interleukin-38 signaling. DR ChiTaRS; IL1RAPL1; human. DR EvolutionaryTrace; Q9NZN1; -. DR GeneWiki; IL1RAPL1; -. DR GenomeRNAi; 11141; -. DR PRO; PR:Q9NZN1; -. DR Proteomes; UP000005640; Chromosome X. DR Bgee; ENSG00000169306; -. DR CleanEx; HS_IL1RAPL1; -. DR ExpressionAtlas; Q9NZN1; baseline and differential. DR Genevisible; Q9NZN1; HS. DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell. DR GO; GO:0009986; C:cell surface; ISS:BHF-UCL. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0030425; C:dendrite; ISS:BHF-UCL. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0045211; C:postsynaptic membrane; NAS:BHF-UCL. DR GO; GO:0005102; F:receptor binding; ISS:BHF-UCL. DR GO; GO:0005245; F:voltage-gated calcium channel activity; ISS:UniProtKB. DR GO; GO:0071345; P:cellular response to cytokine stimulus; TAS:Reactome. DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:BHF-UCL. DR GO; GO:0045920; P:negative regulation of exocytosis; IDA:UniProtKB. DR GO; GO:0030182; P:neuron differentiation; ISS:BHF-UCL. DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; ISS:BHF-UCL. DR GO; GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB. DR GO; GO:0097105; P:presynaptic membrane assembly; ISS:BHF-UCL. DR GO; GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Cell projection; KW Complete proteome; Cytoplasm; Disulfide bond; Glycoprotein; KW Immunoglobulin domain; Membrane; Mental retardation; Polymorphism; KW Receptor; Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 696 Interleukin-1 receptor accessory protein- FT like 1. FT /FTId=PRO_0000015454. FT TOPO_DOM 19 357 Extracellular. {ECO:0000255}. FT TRANSMEM 358 378 Helical. {ECO:0000255}. FT TOPO_DOM 379 696 Cytoplasmic. {ECO:0000255}. FT DOMAIN 19 134 Ig-like C2-type 1. FT DOMAIN 143 232 Ig-like C2-type 2. FT DOMAIN 242 350 Ig-like C2-type 3. FT DOMAIN 403 562 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT REGION 549 644 Interaction with NCS1. FT {ECO:0000269|PubMed:12783849}. FT SITE 34 34 Essential for interaction with PTPRD. FT {ECO:0000250|UniProtKB:P59823}. FT CARBOHYD 63 63 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 122 122 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 138 138 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 213 213 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 264 264 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 331 331 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 31 126 {ECO:0000250|UniProtKB:P59823}. FT DISULFID 53 118 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 143 185 {ECO:0000250|UniProtKB:P59823}. FT DISULFID 164 216 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 267 334 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 379 379 K -> R (in dbSNP:rs138267399). FT {ECO:0000269|PubMed:18801879}. FT /FTId=VAR_062263. FT VARIANT 618 618 Q -> H (in dbSNP:rs890627874). FT {ECO:0000269|PubMed:18801879}. FT /FTId=VAR_062264. FT VARIANT 637 637 T -> S (in dbSNP:rs756672167). FT {ECO:0000269|PubMed:18801879}. FT /FTId=VAR_062265. FT VARIANT 643 643 I -> V (in dbSNP:rs746481663). FT {ECO:0000269|PubMed:18801879}. FT /FTId=VAR_062266. FT STRAND 32 34 {ECO:0000244|PDB:5WY8}. FT STRAND 40 44 {ECO:0000244|PDB:5WY8}. FT STRAND 49 52 {ECO:0000244|PDB:5WY8}. FT HELIX 54 58 {ECO:0000244|PDB:5WY8}. FT HELIX 64 69 {ECO:0000244|PDB:5WY8}. FT STRAND 73 84 {ECO:0000244|PDB:5WY8}. FT STRAND 93 99 {ECO:0000244|PDB:5WY8}. FT STRAND 102 107 {ECO:0000244|PDB:5WY8}. FT HELIX 110 112 {ECO:0000244|PDB:5WY8}. FT STRAND 114 121 {ECO:0000244|PDB:5WY8}. FT STRAND 126 136 {ECO:0000244|PDB:5WY8}. FT STRAND 142 144 {ECO:0000244|PDB:5WY8}. FT STRAND 150 155 {ECO:0000244|PDB:5WY8}. FT STRAND 160 163 {ECO:0000244|PDB:5WY8}. FT HELIX 168 170 {ECO:0000244|PDB:5WY8}. FT STRAND 180 183 {ECO:0000244|PDB:5WY8}. FT STRAND 200 205 {ECO:0000244|PDB:5WY8}. FT HELIX 208 210 {ECO:0000244|PDB:5WY8}. FT STRAND 212 220 {ECO:0000244|PDB:5WY8}. FT STRAND 223 234 {ECO:0000244|PDB:5WY8}. FT STRAND 243 247 {ECO:0000244|PDB:5WY8}. FT STRAND 259 261 {ECO:0000244|PDB:5WY8}. FT STRAND 263 271 {ECO:0000244|PDB:5WY8}. FT STRAND 274 277 {ECO:0000244|PDB:5WY8}. FT STRAND 280 285 {ECO:0000244|PDB:5WY8}. FT TURN 295 297 {ECO:0000244|PDB:5WY8}. FT STRAND 298 300 {ECO:0000244|PDB:5WY8}. FT STRAND 304 309 {ECO:0000244|PDB:5WY8}. FT STRAND 312 323 {ECO:0000244|PDB:5WY8}. FT TURN 326 328 {ECO:0000244|PDB:5WY8}. FT STRAND 330 338 {ECO:0000244|PDB:5WY8}. FT STRAND 341 348 {ECO:0000244|PDB:5WY8}. FT STRAND 405 410 {ECO:0000244|PDB:1T3G}. FT HELIX 426 431 {ECO:0000244|PDB:1T3G}. FT HELIX 433 440 {ECO:0000244|PDB:1T3G}. FT HELIX 449 452 {ECO:0000244|PDB:1T3G}. FT HELIX 459 468 {ECO:0000244|PDB:1T3G}. FT STRAND 470 477 {ECO:0000244|PDB:1T3G}. FT HELIX 479 483 {ECO:0000244|PDB:1T3G}. FT TURN 484 487 {ECO:0000244|PDB:1T3G}. FT HELIX 488 492 {ECO:0000244|PDB:1T3G}. FT HELIX 494 501 {ECO:0000244|PDB:1T3G}. FT STRAND 504 511 {ECO:0000244|PDB:1T3G}. FT HELIX 518 529 {ECO:0000244|PDB:1T3G}. FT STRAND 532 538 {ECO:0000244|PDB:1T3G}. FT HELIX 542 545 {ECO:0000244|PDB:1T3G}. FT STRAND 546 548 {ECO:0000244|PDB:1T3G}. FT HELIX 550 558 {ECO:0000244|PDB:1T3G}. SQ SEQUENCE 696 AA; 79969 MW; 9B7A0B503D73CCA9 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSIDIKK YQVLVGEPVR IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG DSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LVCLVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSSREQ NPDEAHTNSA ILPLLPRETS ISSVIW // ID IRPL1_MOUSE Reviewed; 695 AA. AC P59823; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 1. DT 22-NOV-2017, entry version 108. DE RecName: Full=Interleukin-1 receptor accessory protein-like 1; DE Short=IL-1-RAPL-1; DE Short=IL-1RAPL-1; DE Short=IL1RAPL-1; DE AltName: Full=X-linked interleukin-1 receptor accessory protein-like 1; DE Flags: Precursor; GN Name=Il1rapl1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] RP FUNCTION, INTERACTION WITH PTPRD, AND SUBCELLULAR LOCATION. RX PubMed=21940441; DOI=10.1523/JNEUROSCI.2136-11.2011; RA Yoshida T., Yasumura M., Uemura T., Lee S.J., Ra M., Taguchi R., RA Iwakura Y., Mishina M.; RT "IL-1 receptor accessory protein-like 1 associated with mental RT retardation and autism mediates synapse formation by trans-synaptic RT interaction with protein tyrosine phosphatase delta."; RL J. Neurosci. 31:13485-13499(2011). RN [4] RP TISSUE SPECIFICITY. RX PubMed=12783849; DOI=10.1093/hmg/ddg147; RA Bahi N., Friocourt G., Carrie A., Graham M.E., Weiss J.L., Chafey P., RA Fauchereau F., Burgoyne R.D., Chelly J.; RT "IL1 receptor accessory protein like, a protein involved in X-linked RT mental retardation, interacts with Neuronal Calcium Sensor-1 and RT regulates exocytosis."; RL Hum. Mol. Genet. 12:1415-1425(2003). RN [5] {ECO:0000244|PDB:4YH6, ECO:0000244|PDB:4YH7, ECO:0000244|PDB:5Y32} RP X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 19-352 IN COMPLEX WITH RP PTPRD, GLYCOSYLATION AT ASN-63; ASN-122; ASN-138; ASN-213 AND ASN-264, RP DISULFIDE BONDS, SUBUNIT, INTERACTION WITH PTPRD, MUTAGENESIS OF RP TRP-34; ASP-37; 75-MET--TYR-77; 88-PRO--PHE-91 AND ASP-292, SITE, AND RP FUNCTION. RX PubMed=25908590; DOI=10.1038/ncomms7926; RA Yamagata A., Yoshida T., Sato Y., Goto-Ito S., Uemura T., Maeda A., RA Shiroshima T., Iwasawa-Okamoto S., Mori H., Mishina M., Fukai S.; RT "Mechanisms of splicing-dependent trans-synaptic adhesion by PTPdelta- RT IL1RAPL1/IL-1RAcP for synaptic differentiation."; RL Nat. Commun. 6:6926-6926(2015). CC -!- FUNCTION: May regulate secretion and presynaptic differentiation CC through inhibition of the activity of N-type voltage-gated calcium CC channel. May activate the MAP kinase JNK (By similarity). Plays a CC role in neurite outgrowth (By similarity). During dendritic spine CC formation can bidirectionally induce pre- and post-synaptic CC differentiation of neurons by trans-synaptically binding to PTPRD CC (PubMed:25908590, PubMed:21940441). {ECO:0000250|UniProtKB:P59824, CC ECO:0000250|UniProtKB:Q9NZN1, ECO:0000269|PubMed:21940441, CC ECO:0000269|PubMed:25908590}. CC -!- SUBUNIT: Homodimer (PubMed:25908590). Interacts (calcium- CC independent) with NCS1/FREQ (By similarity). Interacts (via the CC first immunoglobilin domain) with PTPRD (via the second CC immunoglobilin domain); this interaction is PTPRD-splicing- CC dependent and induces pre- and post-synaptic differentiation of CC neurons and is required for IL1RAPL1-mediated synapse formation CC (PubMed:25908590, PubMed:21940441). {ECO:0000250|UniProtKB:Q9NZN1, CC ECO:0000269|PubMed:21940441, ECO:0000269|PubMed:25908590}. CC -!- INTERACTION: CC Q64487:Ptprd; NbExp=6; IntAct=EBI-5452114, EBI-771834; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass CC type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. CC Cell projection, axon {ECO:0000269|PubMed:21940441}. Cell CC projection, dendrite {ECO:0000269|PubMed:21940441}. Note=May CC localize to the cell body and growth cones of dendrite-like CC processes. CC -!- TISSUE SPECIFICITY: Detected in total brain extracts, olfactory CC bulb, hippocampus and striatum (at protein level). CC {ECO:0000269|PubMed:12783849}. CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AL844900; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL672059; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK081272; -; NOT_ANNOTATED_CDS; mRNA. DR UniGene; Mm.121680; -. DR UniGene; Mm.400887; -. DR UniGene; Mm.426143; -. DR PDB; 4YH6; X-ray; 3.00 A; A/B=19-352. DR PDB; 4YH7; X-ray; 4.40 A; B=19-352. DR PDB; 5Y32; X-ray; 2.70 A; B=19-352. DR PDBsum; 4YH6; -. DR PDBsum; 4YH7; -. DR PDBsum; 5Y32; -. DR ProteinModelPortal; P59823; -. DR SMR; P59823; -. DR IntAct; P59823; 1. DR STRING; 10090.ENSMUSP00000077915; -. DR iPTMnet; P59823; -. DR PhosphoSitePlus; P59823; -. DR PaxDb; P59823; -. DR PRIDE; P59823; -. DR MGI; MGI:2687319; Il1rapl1. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR HOVERGEN; HBG052148; -. DR InParanoid; P59823; -. DR ChiTaRS; Il1rapl1; mouse. DR PRO; PR:P59823; -. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_IL1RAPL1; -. DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell. DR GO; GO:0009986; C:cell surface; IDA:BHF-UCL. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0030425; C:dendrite; IDA:BHF-UCL. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0045211; C:postsynaptic membrane; NAS:BHF-UCL. DR GO; GO:0005102; F:receptor binding; IPI:BHF-UCL. DR GO; GO:0005245; F:voltage-gated calcium channel activity; ISS:UniProtKB. DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IDA:BHF-UCL. DR GO; GO:0045920; P:negative regulation of exocytosis; ISS:UniProtKB. DR GO; GO:0030182; P:neuron differentiation; IDA:BHF-UCL. DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IMP:BHF-UCL. DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:UniProtKB. DR GO; GO:0097105; P:presynaptic membrane assembly; IMP:BHF-UCL. DR GO; GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Cell projection; Complete proteome; KW Cytoplasm; Disulfide bond; Glycoprotein; Immunoglobulin domain; KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 695 Interleukin-1 receptor accessory protein- FT like 1. FT /FTId=PRO_0000015455. FT TOPO_DOM 25 357 Extracellular. {ECO:0000255}. FT TRANSMEM 358 378 Helical. {ECO:0000255}. FT TOPO_DOM 379 695 Cytoplasmic. {ECO:0000255}. FT DOMAIN 25 134 Ig-like C2-type 1. FT DOMAIN 143 232 Ig-like C2-type 2. FT DOMAIN 242 350 Ig-like C2-type 3. FT DOMAIN 403 561 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT REGION 548 643 Interaction with NCS1. {ECO:0000250}. FT SITE 34 34 Essential for interaction with PTPRD. FT {ECO:0000269|PubMed:25908590}. FT CARBOHYD 63 63 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:5Y32, FT ECO:0000269|PubMed:25908590}. FT CARBOHYD 122 122 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000269|PubMed:25908590}. FT CARBOHYD 138 138 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000269|PubMed:25908590}. FT CARBOHYD 213 213 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000269|PubMed:25908590}. FT CARBOHYD 264 264 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000269|PubMed:25908590}. FT CARBOHYD 331 331 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 31 126 {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000269|PubMed:25908590}. FT DISULFID 53 118 {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:25908590}. FT DISULFID 143 185 {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000269|PubMed:25908590}. FT DISULFID 164 216 {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:25908590}. FT DISULFID 267 334 {ECO:0000244|PDB:4YH6, FT ECO:0000244|PDB:4YH7, FT ECO:0000244|PDB:5Y32, FT ECO:0000255|PROSITE-ProRule:PRU00114, FT ECO:0000269|PubMed:25908590}. FT MUTAGEN 34 34 W->A: Abolishes Interaction with PTPRD. FT Abolishes synaptogenesis. FT {ECO:0000269|PubMed:25908590}. FT MUTAGEN 37 37 D->A: Decreases affinity for PTPRD. FT Significantly decreases synaptogenesis. FT {ECO:0000269|PubMed:25908590}. FT MUTAGEN 75 77 MWY->AWA: Decreases affinity for PTPRD; FT when associated with 88-A--A-91. FT Significantly decreases synaptogenesis; FT when associated with 88-A--A-91. FT {ECO:0000269|PubMed:25908590}. FT MUTAGEN 88 91 PIAF->AIAA: Decreases affinity for PTPRD; FT when associated with 75-A--A-77. FT Significantly decreases synaptogenesis; FT when associated with 88-A--A-91. FT {ECO:0000269|PubMed:25908590}. FT MUTAGEN 292 292 D->A: Decreases affinity for PTPRD. FT Significantly decreases synaptogenesis. FT {ECO:0000269|PubMed:25908590}. FT STRAND 32 36 {ECO:0000244|PDB:5Y32}. FT STRAND 41 44 {ECO:0000244|PDB:5Y32}. FT STRAND 49 52 {ECO:0000244|PDB:5Y32}. FT HELIX 54 57 {ECO:0000244|PDB:5Y32}. FT STRAND 60 62 {ECO:0000244|PDB:5Y32}. FT HELIX 64 69 {ECO:0000244|PDB:5Y32}. FT STRAND 73 81 {ECO:0000244|PDB:5Y32}. FT STRAND 93 97 {ECO:0000244|PDB:5Y32}. FT STRAND 102 107 {ECO:0000244|PDB:5Y32}. FT HELIX 110 112 {ECO:0000244|PDB:5Y32}. FT STRAND 114 121 {ECO:0000244|PDB:5Y32}. FT STRAND 126 136 {ECO:0000244|PDB:5Y32}. FT STRAND 142 145 {ECO:0000244|PDB:5Y32}. FT STRAND 146 148 {ECO:0000244|PDB:4YH6}. FT STRAND 150 155 {ECO:0000244|PDB:5Y32}. FT STRAND 160 163 {ECO:0000244|PDB:5Y32}. FT TURN 168 170 {ECO:0000244|PDB:5Y32}. FT STRAND 173 175 {ECO:0000244|PDB:5Y32}. FT STRAND 180 183 {ECO:0000244|PDB:5Y32}. FT STRAND 194 196 {ECO:0000244|PDB:5Y32}. FT STRAND 198 205 {ECO:0000244|PDB:5Y32}. FT HELIX 208 210 {ECO:0000244|PDB:5Y32}. FT STRAND 212 220 {ECO:0000244|PDB:5Y32}. FT STRAND 223 234 {ECO:0000244|PDB:5Y32}. FT STRAND 243 247 {ECO:0000244|PDB:5Y32}. FT STRAND 249 251 {ECO:0000244|PDB:5Y32}. FT STRAND 253 257 {ECO:0000244|PDB:5Y32}. FT STRAND 263 271 {ECO:0000244|PDB:5Y32}. FT STRAND 280 285 {ECO:0000244|PDB:5Y32}. FT STRAND 288 290 {ECO:0000244|PDB:5Y32}. FT STRAND 296 300 {ECO:0000244|PDB:5Y32}. FT STRAND 304 308 {ECO:0000244|PDB:5Y32}. FT STRAND 313 323 {ECO:0000244|PDB:5Y32}. FT TURN 326 328 {ECO:0000244|PDB:5Y32}. FT STRAND 330 338 {ECO:0000244|PDB:5Y32}. FT STRAND 341 351 {ECO:0000244|PDB:5Y32}. SQ SEQUENCE 695 AA; 79630 MW; 5FE34F204E5908B7 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKAW RPSIVFKRDT LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTVQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LICSVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGNIE DVARCVDQSK RLIIVMTPNY VVRRGWSIFE LETRLRNMLV TGEIKVILIE CSELRGIMNY QEVEALKHTI KLLTVIKWHG PKCNKLNSKF WKRLQYEMPF KRIEPITHEQ ALDVSEQGPF GELQTVSAIS MAAATSTALA TAHPDLRSTF HNTYHSQMRQ KHYYRSYEYD VPPTGTLPLT SIGNQHTYCN IPMTLINGQR PQTKSNREPN PDEAHTNSAI LPLLPRETSI SSVIW // ID IRPL1_PANTR Reviewed; 696 AA. AC P60029; DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 21-NOV-2003, sequence version 1. DT 28-MAR-2018, entry version 102. DE RecName: Full=Interleukin-1 receptor accessory protein-like 1; DE Short=IL-1-RAPL-1; DE Short=IL-1RAPL-1; DE Short=IL1RAPL-1; DE AltName: Full=Oligophrenin-4; DE AltName: Full=X-linked interleukin-1 receptor accessory protein-like 1; DE Flags: Precursor; GN Name=IL1RAPL1; Synonyms=OPHN4; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=12777533; DOI=10.1093/molbev/msg134; RA Kitano T., Schwarz C., Nickel B., Paeaebo S.; RT "Gene diversity patterns at 10 X-chromosomal loci in humans and RT chimpanzees."; RL Mol. Biol. Evol. 20:1281-1289(2003). CC -!- FUNCTION: May regulate secretion and presynaptic differentiation CC through inhibition of the activity of N-type voltage-gated calcium CC channel. May activate the MAP kinase JNK (By similarity). Plays a CC role in neurite outgrowth (By similarity). During dendritic spine CC formation can bidirectionally induce pre- and post-synaptic CC differentiation of neurons by trans-synaptically binding to PTPRD CC (By similarity). {ECO:0000250|UniProtKB:P59823, CC ECO:0000250|UniProtKB:P59824, ECO:0000250|UniProtKB:Q9NZN1}. CC -!- SUBUNIT: Homodimer (By similarity). Interacts (calcium- CC independent) with NCS1/FREQ (By similarity). Interacts (via the CC first immunoglobilin domain) with PTPRD (via the second CC immunoglobilin domain); this interaction is PTPRD-splicing- CC dependent and induces pre- and post-synaptic differentiation of CC neurons and is required for IL1RAPL1-mediated synapse formation CC (By similarity). {ECO:0000250|UniProtKB:P59823, CC ECO:0000250|UniProtKB:Q9NZN1}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass CC type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. CC Cell projection, axon {ECO:0000250}. Cell projection, dendrite CC {ECO:0000250}. Note=May localize to the cell body and growth cones CC of dendrite-like processes. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB102651; BAC81120.1; -; mRNA. DR RefSeq; NP_001009038.1; NM_001009038.1. DR RefSeq; XP_009437156.1; XM_009438881.2. DR UniGene; Ptr.6247; -. DR ProteinModelPortal; P60029; -. DR SMR; P60029; -. DR STRING; 9598.ENSPTRP00000037316; -. DR PaxDb; P60029; -. DR Ensembl; ENSPTRT00000040384; ENSPTRP00000037316; ENSPTRG00000021762. DR GeneID; 450116; -. DR KEGG; ptr:450116; -. DR CTD; 11141; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR HOGENOM; HOG000092977; -. DR HOVERGEN; HBG052148; -. DR InParanoid; P60029; -. DR KO; K05170; -. DR Proteomes; UP000002277; Chromosome X. DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0005245; F:voltage-gated calcium channel activity; ISS:UniProtKB. DR GO; GO:0045920; P:negative regulation of exocytosis; ISS:UniProtKB. DR GO; GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB. DR GO; GO:0010975; P:regulation of neuron projection development; ISS:UniProtKB. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Cell membrane; Cell projection; Complete proteome; Cytoplasm; KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; KW Receptor; Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 696 Interleukin-1 receptor accessory protein- FT like 1. FT /FTId=PRO_0000015456. FT TOPO_DOM 19 357 Extracellular. {ECO:0000255}. FT TRANSMEM 358 378 Helical. {ECO:0000255}. FT TOPO_DOM 379 696 Cytoplasmic. {ECO:0000255}. FT DOMAIN 19 134 Ig-like C2-type 1. FT DOMAIN 143 232 Ig-like C2-type 2. FT DOMAIN 242 350 Ig-like C2-type 3. FT DOMAIN 403 562 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT REGION 549 644 Interaction with NCS1. {ECO:0000250}. FT SITE 34 34 Essential for interaction with PTPRD. FT {ECO:0000250|UniProtKB:P59823}. FT CARBOHYD 63 63 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 122 122 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 138 138 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 213 213 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 264 264 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 331 331 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 31 126 {ECO:0000250|UniProtKB:P59823}. FT DISULFID 53 118 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 143 185 {ECO:0000250|UniProtKB:P59823}. FT DISULFID 164 216 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 267 334 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 696 AA; 79969 MW; 9B7A0B503D73CCA9 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSIDIKK YQVLVGEPVR IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG DSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LVCLVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSSREQ NPDEAHTNSA ILPLLPRETS ISSVIW // ID IRPL1_RAT Reviewed; 696 AA. AC P59824; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 1. DT 28-FEB-2018, entry version 104. DE RecName: Full=Interleukin-1 receptor accessory protein-like 1; DE Short=IL-1-RAPL-1; DE Short=IL-1RAPL-1; DE Short=IL1RAPL-1; DE AltName: Full=X-linked interleukin-1 receptor accessory protein-like 1; DE Flags: Precursor; GN Name=Il1rapl1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Wistar; TISSUE=Hippocampus; RA Boda B., Parisi L., Muller D.; RT "Full length cloning of rat IL1RAPL in the hippocampus."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP FUNCTION. RX PubMed=17502602; DOI=10.1073/pnas.0701133104; RA Gambino F., Pavlowsky A., Begle A., Dupont J.-L., Bahi N., RA Courjaret R., Gardette R., Hadjkacem H., Skala H., Poulain B., RA Chelly J., Vitale N., Humeau Y.; RT "IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved RT in cognitive functions, regulates N-type Ca2+-channel and neurite RT elongation."; RL Proc. Natl. Acad. Sci. U.S.A. 104:9063-9068(2007). RN [3] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=18801879; DOI=10.1093/hmg/ddn300; RA Piton A., Michaud J.L., Peng H., Aradhya S., Gauthier J., Mottron L., RA Champagne N., Lafreniere R.G., Hamdan F.F., Joober R., Fombonne E., RA Marineau C., Cossette P., Dube M.P., Haghighi P., Drapeau P., RA Barker P.A., Carbonetto S., Rouleau G.A.; RT "Mutations in the calcium-related gene IL1RAPL1 are associated with RT autism."; RL Hum. Mol. Genet. 17:3965-3974(2008). CC -!- FUNCTION: May regulate secretion and presynaptic differentiation CC through inhibition of the activity of N-type voltage-gated calcium CC channel (PubMed:17502602). May activate the MAP kinase JNK (By CC similarity). Plays a role in neurite outgrowth (PubMed:18801879). CC During dendritic spine formation can bidirectionally induce CC pre- and post-synaptic differentiation of neurons by trans- CC synaptically binding to PTPRD (By similarity). CC {ECO:0000250|UniProtKB:P59823, ECO:0000250|UniProtKB:Q9NZN1, CC ECO:0000269|PubMed:17502602, ECO:0000269|PubMed:18801879}. CC -!- SUBUNIT: Homodimer (By similarity). Interacts (calcium- CC independent) with NCS1/FREQ (By similarity). Interacts (via the CC first immunoglobilin domain) with PTPRD (via the second CC immunoglobilin domain); this interaction is PTPRD-splicing- CC dependent and induces pre- and post-synaptic differentiation of CC neurons and is required for IL1RAPL1-mediated synapse formation CC (By similarity). {ECO:0000250|UniProtKB:P59823, CC ECO:0000250|UniProtKB:Q9NZN1}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18801879}; CC Single-pass type I membrane protein {ECO:0000269|PubMed:18801879}. CC Cytoplasm {ECO:0000269|PubMed:18801879}. Cell projection, axon CC {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=May CC localize to the cell body and growth cones of dendrite-like CC processes. CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY216593; AAO62634.1; -; mRNA. DR RefSeq; NP_808796.1; NM_177935.2. DR UniGene; Rn.214479; -. DR ProteinModelPortal; P59824; -. DR SMR; P59824; -. DR STRING; 10116.ENSRNOP00000061591; -. DR CarbonylDB; P59824; -. DR iPTMnet; P59824; -. DR PhosphoSitePlus; P59824; -. DR SwissPalm; P59824; -. DR PaxDb; P59824; -. DR PRIDE; P59824; -. DR GeneID; 317553; -. DR KEGG; rno:317553; -. DR CTD; 11141; -. DR RGD; 727891; Il1rapl1. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR HOGENOM; HOG000092977; -. DR HOVERGEN; HBG052148; -. DR InParanoid; P59824; -. DR KO; K05170; -. DR PhylomeDB; P59824; -. DR PRO; PR:P59824; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell. DR GO; GO:0009986; C:cell surface; ISO:RGD. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0030425; C:dendrite; ISO:RGD. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0005102; F:receptor binding; ISO:RGD. DR GO; GO:0005245; F:voltage-gated calcium channel activity; IDA:UniProtKB. DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISO:RGD. DR GO; GO:0045920; P:negative regulation of exocytosis; IDA:UniProtKB. DR GO; GO:0030182; P:neuron differentiation; ISO:RGD. DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; ISO:RGD. DR GO; GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB. DR GO; GO:0097105; P:presynaptic membrane assembly; ISO:RGD. DR GO; GO:0010975; P:regulation of neuron projection development; IDA:UniProtKB. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Cell membrane; Cell projection; Complete proteome; Cytoplasm; KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; KW Receptor; Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 24 {ECO:0000255}. FT CHAIN 25 696 Interleukin-1 receptor accessory protein- FT like 1. FT /FTId=PRO_0000015458. FT TOPO_DOM 25 357 Extracellular. {ECO:0000255}. FT TRANSMEM 358 378 Helical. {ECO:0000255}. FT TOPO_DOM 379 696 Cytoplasmic. {ECO:0000255}. FT DOMAIN 25 134 Ig-like C2-type 1. FT DOMAIN 143 232 Ig-like C2-type 2. FT DOMAIN 242 350 Ig-like C2-type 3. FT DOMAIN 403 562 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT REGION 549 644 Interaction with NCS1. {ECO:0000250}. FT SITE 34 34 Essential for interaction with PTPRD. FT {ECO:0000250|UniProtKB:P59823}. FT CARBOHYD 63 63 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 122 122 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 138 138 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 213 213 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 264 264 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 331 331 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 31 126 {ECO:0000250|UniProtKB:P59823}. FT DISULFID 53 118 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 143 185 {ECO:0000250|UniProtKB:P59823}. FT DISULFID 164 216 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 267 334 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 696 AA; 79771 MW; 3684FCCD0A0B3FD9 CRC64; MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR IKCALFYGYI RTNYTLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL AGGLGAILLL LVCSVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ RPQTKSSREP NPDEAHTNSA ILPLLARETS ISSVIW // ID IRPL2_HUMAN Reviewed; 686 AA. AC Q9NP60; Q2M3U3; Q9NZN0; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 28-MAR-2018, entry version 138. DE RecName: Full=X-linked interleukin-1 receptor accessory protein-like 2; DE Short=IL-1 receptor accessory protein-like 2; DE Short=IL-1-RAPL-2; DE Short=IL-1RAPL-2; DE Short=IL1RAPL-2; DE AltName: Full=IL1RAPL-2-related protein; DE AltName: Full=Interleukin-1 receptor 9; DE Short=IL-1R-9; DE Short=IL-1R9; DE AltName: Full=Three immunoglobulin domain-containing IL-1 receptor-related 1; DE Short=TIGIRR-1; DE Flags: Precursor; GN Name=IL1RAPL2; Synonyms=IL1R9; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Fetal brain; RX PubMed=11031108; DOI=10.1006/geno.2000.6328; RA Sana T.R., Debets R., Timans J.C., Bazan J.F., Kastelein R.A.; RT "Computational identification, cloning, and characterization of IL- RT 1R9, a novel interleukin-1 receptor-like gene encoded over an RT unusually large interval of human chromosome Xq22.2-q22.3."; RL Genomics 69:252-262(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Liver; RX PubMed=10882729; DOI=10.1074/jbc.M004077200; RA Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., RA Sims J.E.; RT "Identification and characterization of two members of a novel class RT of the interleukin-1 receptor (IL-1R) family. Delineation of a new RT class of IL-1R-related proteins based on signaling."; RL J. Biol. Chem. 275:29946-29954(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RA Grabowski M., Lorenz B., Hubel R., Strom T.M.; RT "A gene (IL1RAPL-2) with 61% identity to IL1RAPL maps to Xq22.2."; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Brain; RX PubMed=11587848; DOI=10.1016/S0378-1119(01)00659-X; RA Ferrante M.I., Ghiani M., Bulfone A., Franco B.; RT "IL1RAPL2 maps to Xq22 and is specifically expressed in the central RT nervous system."; RL Gene 275:217-221(2001). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Thalamus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., RA Williams G., Williams L., Williamson A., Williamson H., Wilming L., RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 29-686. RX PubMed=10757639; DOI=10.1038/sj.ejhg.5200415; RA Jin H., Gardner R.J., Viswesvaraiah R., Muntoni F., Roberts R.G.; RT "Two novel members of the interleukin-1 receptor gene family, one RT deleted in Xp22.3-Xp21.3 mental retardation."; RL Eur. J. Hum. Genet. 8:87-94(2000). RN [9] RP VARIANT [LARGE SCALE ANALYSIS] LEU-606. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- TISSUE SPECIFICITY: Detected at low levels in fetal and adult CC brain, in particular in the frontal lobe, temporal lobe and CC cerebellum. Detected at very low levels in skin, liver, fetal CC ovary and in placenta. {ECO:0000269|PubMed:10882729, CC ECO:0000269|PubMed:11031108, ECO:0000269|PubMed:11587848}. CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF212016; AAF61307.1; -; mRNA. DR EMBL; AF284436; AAG21370.1; -; mRNA. DR EMBL; AJ272208; CAB86868.1; -; mRNA. DR EMBL; AJ290436; CAB89867.1; -; mRNA. DR EMBL; AK290196; BAF82885.1; -; mRNA. DR EMBL; Z81144; CAI41969.1; -; Genomic_DNA. DR EMBL; AL050401; CAI41969.1; JOINED; Genomic_DNA. DR EMBL; Z68328; CAI41969.1; JOINED; Genomic_DNA. DR EMBL; Z68330; CAI41969.1; JOINED; Genomic_DNA. DR EMBL; Z68908; CAI41969.1; JOINED; Genomic_DNA. DR EMBL; Z69721; CAI41969.1; JOINED; Genomic_DNA. DR EMBL; Z74477; CAI41969.1; JOINED; Genomic_DNA. DR EMBL; Z74619; CAI41969.1; JOINED; Genomic_DNA. DR EMBL; Z69721; CAI41981.1; -; Genomic_DNA. DR EMBL; AL050401; CAI41981.1; JOINED; Genomic_DNA. DR EMBL; Z68328; CAI41981.1; JOINED; Genomic_DNA. DR EMBL; Z68330; CAI41981.1; JOINED; Genomic_DNA. DR EMBL; Z68908; CAI41981.1; JOINED; Genomic_DNA. DR EMBL; Z74477; CAI41981.1; JOINED; Genomic_DNA. DR EMBL; Z74619; CAI41981.1; JOINED; Genomic_DNA. DR EMBL; Z81144; CAI41981.1; JOINED; Genomic_DNA. DR EMBL; Z68908; CAI41987.1; -; Genomic_DNA. DR EMBL; AL050401; CAI41987.1; JOINED; Genomic_DNA. DR EMBL; Z68328; CAI41987.1; JOINED; Genomic_DNA. DR EMBL; Z68330; CAI41987.1; JOINED; Genomic_DNA. DR EMBL; Z69721; CAI41987.1; JOINED; Genomic_DNA. DR EMBL; Z74477; CAI41987.1; JOINED; Genomic_DNA. DR EMBL; Z74619; CAI41987.1; JOINED; Genomic_DNA. DR EMBL; Z81144; CAI41987.1; JOINED; Genomic_DNA. DR EMBL; Z74619; CAI41989.1; -; Genomic_DNA. DR EMBL; AL050401; CAI41989.1; JOINED; Genomic_DNA. DR EMBL; Z68328; CAI41989.1; JOINED; Genomic_DNA. DR EMBL; Z68330; CAI41989.1; JOINED; Genomic_DNA. DR EMBL; Z68908; CAI41989.1; JOINED; Genomic_DNA. DR EMBL; Z69721; CAI41989.1; JOINED; Genomic_DNA. DR EMBL; Z74477; CAI41989.1; JOINED; Genomic_DNA. DR EMBL; Z81144; CAI41989.1; JOINED; Genomic_DNA. DR EMBL; Z68328; CAI42001.1; -; Genomic_DNA. DR EMBL; AL050401; CAI42001.1; JOINED; Genomic_DNA. DR EMBL; Z68330; CAI42001.1; JOINED; Genomic_DNA. DR EMBL; Z68908; CAI42001.1; JOINED; Genomic_DNA. DR EMBL; Z69721; CAI42001.1; JOINED; Genomic_DNA. DR EMBL; Z74477; CAI42001.1; JOINED; Genomic_DNA. DR EMBL; Z74619; CAI42001.1; JOINED; Genomic_DNA. DR EMBL; Z81144; CAI42001.1; JOINED; Genomic_DNA. DR EMBL; Z68330; CAI42006.1; -; Genomic_DNA. DR EMBL; AL050401; CAI42006.1; JOINED; Genomic_DNA. DR EMBL; Z68328; CAI42006.1; JOINED; Genomic_DNA. DR EMBL; Z68908; CAI42006.1; JOINED; Genomic_DNA. DR EMBL; Z69721; CAI42006.1; JOINED; Genomic_DNA. DR EMBL; Z74477; CAI42006.1; JOINED; Genomic_DNA. DR EMBL; Z74619; CAI42006.1; JOINED; Genomic_DNA. DR EMBL; Z81144; CAI42006.1; JOINED; Genomic_DNA. DR EMBL; AL050401; CAI42894.1; -; Genomic_DNA. DR EMBL; Z68328; CAI42894.1; JOINED; Genomic_DNA. DR EMBL; Z68330; CAI42894.1; JOINED; Genomic_DNA. DR EMBL; Z68908; CAI42894.1; JOINED; Genomic_DNA. DR EMBL; Z69721; CAI42894.1; JOINED; Genomic_DNA. DR EMBL; Z74477; CAI42894.1; JOINED; Genomic_DNA. DR EMBL; Z74619; CAI42894.1; JOINED; Genomic_DNA. DR EMBL; Z81144; CAI42894.1; JOINED; Genomic_DNA. DR EMBL; AF181285; AAF59412.1; -; mRNA. DR EMBL; BC104784; AAI04785.1; -; mRNA. DR EMBL; BC104786; AAI04787.1; -; mRNA. DR CCDS; CCDS14517.1; -. DR RefSeq; NP_059112.1; NM_017416.1. DR RefSeq; XP_016884892.1; XM_017029403.1. DR UniGene; Hs.675519; -. DR ProteinModelPortal; Q9NP60; -. DR SMR; Q9NP60; -. DR BioGrid; 117663; 1. DR STRING; 9606.ENSP00000344976; -. DR iPTMnet; Q9NP60; -. DR PhosphoSitePlus; Q9NP60; -. DR BioMuta; IL1RAPL2; -. DR DMDM; 34222651; -. DR PaxDb; Q9NP60; -. DR PRIDE; Q9NP60; -. DR Ensembl; ENST00000372582; ENSP00000361663; ENSG00000189108. DR GeneID; 26280; -. DR KEGG; hsa:26280; -. DR UCSC; uc004elz.1; human. DR CTD; 26280; -. DR DisGeNET; 26280; -. DR EuPathDB; HostDB:ENSG00000189108.12; -. DR GeneCards; IL1RAPL2; -. DR HGNC; HGNC:5997; IL1RAPL2. DR HPA; HPA036128; -. DR HPA; HPA036129; -. DR MIM; 300277; gene. DR neXtProt; NX_Q9NP60; -. DR OpenTargets; ENSG00000189108; -. DR PharmGKB; PA29813; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR HOGENOM; HOG000092977; -. DR HOVERGEN; HBG052148; -. DR InParanoid; Q9NP60; -. DR KO; K05170; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR PhylomeDB; Q9NP60; -. DR TreeFam; TF333913; -. DR Reactome; R-HSA-388844; Receptor-type tyrosine-protein phosphatases. DR ChiTaRS; IL1RAPL2; human. DR GeneWiki; IL1RAPL2; -. DR GenomeRNAi; 26280; -. DR PRO; PR:Q9NP60; -. DR Proteomes; UP000005640; Chromosome X. DR Bgee; ENSG00000189108; -. DR CleanEx; HS_IL1RAPL2; -. DR ExpressionAtlas; Q9NP60; baseline and differential. DR Genevisible; Q9NP60; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0004908; F:interleukin-1 receptor activity; TAS:ProtInc. DR GO; GO:0004910; F:interleukin-1, Type II, blocking receptor activity; IEA:InterPro. DR GO; GO:0007417; P:central nervous system development; TAS:ProtInc. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004077; IL-1_rcpt_II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01539; INTRLEUKN1R2. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Complete proteome; Disulfide bond; Glycoprotein; KW Immunoglobulin domain; Membrane; Polymorphism; Receptor; KW Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 16 {ECO:0000255}. FT CHAIN 17 686 X-linked interleukin-1 receptor accessory FT protein-like 2. FT /FTId=PRO_0000015459. FT TOPO_DOM 17 354 Extracellular. {ECO:0000255}. FT TRANSMEM 355 375 Helical. {ECO:0000255}. FT TOPO_DOM 376 686 Cytoplasmic. {ECO:0000255}. FT DOMAIN 18 132 Ig-like C2-type 1. FT DOMAIN 141 232 Ig-like C2-type 2. FT DOMAIN 239 347 Ig-like C2-type 3. FT DOMAIN 400 559 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 63 63 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 120 120 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 136 136 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 211 211 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 328 328 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 53 116 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 162 214 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 265 331 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VARIANT 606 606 F -> L (in a breast cancer sample; FT somatic mutation). FT {ECO:0000269|PubMed:16959974}. FT /FTId=VAR_036592. SQ SEQUENCE 686 AA; 78670 MW; E400F7ECD186957C CRC64; MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGSK SSKLNSKFWK HLVYEMPIKK KEMLPRCHVL DSAEQGLFGE LQPIPSIAMT STSATLVSSQ ADLPEFHPSD SMQIRHCCRG YKHEIPATTL PVPSLGNHHT YCNLPLTLLN GQLPLNNTLK DTQEFHRNSS LLPLSSKELS FTSDIW // ID IRPL2_MOUSE Reviewed; 686 AA. AC Q9ERS6; Q9ER66; DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 28-MAR-2018, entry version 126. DE RecName: Full=X-linked interleukin-1 receptor accessory protein-like 2; DE Short=IL-1 receptor accessory protein-like 2; DE Short=IL-1-RAPL-2; DE Short=IL-1RAPL-2; DE Short=IL1RAPL-2; DE AltName: Full=IL1RAPL-2-related protein; DE AltName: Full=Three immunoglobulin domain-containing IL-1 receptor-related 1; DE Short=TIGIRR-1; DE Flags: Precursor; GN Name=Il1rapl2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Brain, and Liver; RX PubMed=10882729; DOI=10.1074/jbc.M004077200; RA Born T.L., Smith D.E., Garka K.E., Renshaw B.R., Bertles J.S., RA Sims J.E.; RT "Identification and characterization of two members of a novel class RT of the interleukin-1 receptor (IL-1R) family. Delineation of a new RT class of IL-1R-related proteins based on signaling."; RL J. Biol. Chem. 275:29946-29954(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY. RC TISSUE=Brain; RX PubMed=11587848; DOI=10.1016/S0378-1119(01)00659-X; RA Ferrante M.I., Ghiani M., Bulfone A., Franco B.; RT "IL1RAPL2 maps to Xq22 and is specifically expressed in the central RT nervous system."; RL Gene 275:217-221(2001). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9ERS6-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9ERS6-2; Sequence=VSP_008056, VSP_008057; CC Note=may be due to an intron retention.; CC -!- TISSUE SPECIFICITY: Detected in fetal brain after day 12.5, in CC particular in parts of the diencephalon and in the basal plate of CC the spinal cord. In postnatal brain detected in cerebral cortex, CC olfactory bulb, in the CA1 region of the hippocampus and in CC Purkinje cells of the Xth cerebellar lobule. CC {ECO:0000269|PubMed:11587848}. CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF284437; AAG21371.1; -; mRNA. DR EMBL; AJ277831; CAC10559.1; -; mRNA. DR CCDS; CCDS30429.1; -. [Q9ERS6-1] DR RefSeq; NP_109613.1; NM_030688.2. [Q9ERS6-1] DR UniGene; Mm.328321; -. DR ProteinModelPortal; Q9ERS6; -. DR SMR; Q9ERS6; -. DR iPTMnet; Q9ERS6; -. DR PhosphoSitePlus; Q9ERS6; -. DR PaxDb; Q9ERS6; -. DR PRIDE; Q9ERS6; -. DR Ensembl; ENSMUST00000075471; ENSMUSP00000074917; ENSMUSG00000059203. [Q9ERS6-1] DR Ensembl; ENSMUST00000113063; ENSMUSP00000108686; ENSMUSG00000059203. [Q9ERS6-1] DR GeneID; 60367; -. DR KEGG; mmu:60367; -. DR UCSC; uc009ujt.1; mouse. [Q9ERS6-2] DR UCSC; uc009ujv.1; mouse. [Q9ERS6-1] DR CTD; 26280; -. DR MGI; MGI:1913106; Il1rapl2. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR HOGENOM; HOG000092977; -. DR HOVERGEN; HBG052148; -. DR InParanoid; Q9ERS6; -. DR KO; K05170; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR PhylomeDB; Q9ERS6; -. DR TreeFam; TF333913; -. DR Reactome; R-MMU-388844; Receptor-type tyrosine-protein phosphatases. DR ChiTaRS; Il1rapl2; mouse. DR PRO; PR:Q9ERS6; -. DR Proteomes; UP000000589; Chromosome X. DR Bgee; ENSMUSG00000059203; -. DR CleanEx; MM_IL1RAPL2; -. DR ExpressionAtlas; Q9ERS6; baseline and differential. DR Genevisible; Q9ERS6; MM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004910; F:interleukin-1, Type II, blocking receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004077; IL-1_rcpt_II-typ. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01539; INTRLEUKN1R2. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 16 {ECO:0000255}. FT CHAIN 17 686 X-linked interleukin-1 receptor accessory FT protein-like 2. FT /FTId=PRO_0000015460. FT TOPO_DOM 17 354 Extracellular. {ECO:0000255}. FT TRANSMEM 355 375 Helical. {ECO:0000255}. FT TOPO_DOM 376 686 Cytoplasmic. {ECO:0000255}. FT DOMAIN 32 132 Ig-like C2-type 1. FT DOMAIN 141 232 Ig-like C2-type 2. FT DOMAIN 239 347 Ig-like C2-type 3. FT DOMAIN 400 559 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 63 63 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 120 120 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 136 136 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 211 211 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 328 328 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 53 116 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 162 214 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT DISULFID 265 331 {ECO:0000255|PROSITE-ProRule:PRU00114}. FT VAR_SEQ 350 354 DLIYK -> GILFS (in isoform 2). FT {ECO:0000303|PubMed:11587848}. FT /FTId=VSP_008056. FT VAR_SEQ 355 686 Missing (in isoform 2). FT {ECO:0000303|PubMed:11587848}. FT /FTId=VSP_008057. SQ SEQUENCE 686 AA; 78798 MW; 36160D1CDE9B8264 CRC64; MKLPLLLALV VCSAVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI RTNYSMAQST GLRLMWYRNK GDLEEPIIFS EVRMSKEEDA IWFHSAEEQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI RLLKEHLGEK EVELTLIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG LGAIFLLLIL LLVVYKCYNI ELMLFYRQRF GGDETTDDNK EYDAYLSYTK VDQDTLDCDN TEEEQFALEI LPDVLEKHYG YKLFIPERDL IPSGTYIEDL TRCVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKHNIKL LSLIKWKGPK SSKLNSKFWK HLVYEMPIKK KEMLSHCHVL DSAEQGLFGE LQPIPSIAMT STSATMVPSQ ADLPEFHHSD SMQMRHCCRG YQHEMPANTL SVPSLGNHHT YCNLPLTLLN GQLPLNNSLK ETEEFSRNNP LLPLTSKELS FTSDIW // ID K4CFH6_SOLLC Unreviewed; 973 AA. AC K4CFH6; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 28-FEB-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Solyc07g052770.2.1}; OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; OC Solaneae; Solanum; Lycopersicon. OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc07g052770.2.1, ECO:0000313|Proteomes:UP000004994}; RN [1] {ECO:0000313|EnsemblPlants:Solyc07g052770.2.1} RP IDENTIFICATION. RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc07g052770.2.1}; RG EnsemblPlants; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 4081.Solyc07g052770.2.1; -. DR PaxDb; K4CFH6; -. DR EnsemblPlants; Solyc07g052770.2.1; Solyc07g052770.2.1; Solyc07g052770.2. DR Gramene; Solyc07g052770.2.1; Solyc07g052770.2.1; Solyc07g052770.2. DR eggNOG; COG4886; LUCA. DR InParanoid; K4CFH6; -. DR OMA; MESNEAR; -. DR OrthoDB; EOG093600G2; -. DR Proteomes; UP000004994; Chromosome 7. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000004994}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000004994}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 10 151 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 973 AA; 111403 MW; 7E66AE84D4711A72 CRC64; MSHASSSKVC KYDIFLSFGG EDTRRTFVSH LYNALEQRGI HAFKDDERLE AGQSIFAELL KAIEDARFAV VIFSKSYASS RWCLEELVHI IKCKNELEQA VIPVFYDVSP ADVRHQNSPS VDSFFQHEVK YKDDMEKVQR WRGAFAEAGN ISDEAECVKK LVDDIFPKSL QIISPFRESL VGMRSQLEKV IELLSMESNE ARSIGISGMG GIGKSRLAHV LYERYRHLFE ADCFLGDVGE LHLKNGLAWL AQVVIHKLLG EKMSVTSEHE GMIILKNRLR WKKVLFILDD VNHREQLEFL VGGTEWFGMG SRIILTSRDK HLLISHVGDN VYEVQLLSED EALELFSTHA FREKSPKEDF MKLSREVVEH ACGLPLALKV LGSSFYRRDK KHWRHIIDRL KRIPHKDILG KLRLSFDGLE KDEKELFLDI TFLNFAFLDM EYLARPDFDL YVELLRRDPN RGFLIDYLIE KSLLSIDLNN GIVMHNMIRE MGENVIREEY ANSRIWLPEE ICDLFDGKLI TEKVESLLIP EYYYFEENLV DYSNTFKRMQ SLQILIILTY SLHCPITYLP SSLRFIDWIA YPSISLPESF EQSQLVMLRL PESCLVELLP ISKKLSNLKH LDLSNCYELT KSPNFCDMPV LETLNLQGCE NLEEVHPSLG HCRMLTYLIL SYCDKLKKLP KFVCMNSLKH LDLSNCTRSS WIRSLSPSLS GLRELKLDDC EILESIPDTI RNLSDLSISG CNKLTTLPDS LFESQQLEYL YIHRCSGLVK LPSSLGVQKN LGSLEMDRCE NLQKFPSSIW MESLQRLKIF NLPKLDTFPE IKGDMHCLEA LTLTSTGIRE VPSSIGNLSG LTSLNLSGCE DLVSLPDNLC NLMNLRKLNL RGCKSLEKLP ENIGDLHQVS VLSLPKLHLI TPYRLGGLPE ELRGLHFLNG LDVSGSNISC LPKSFKGLFP LRKLNEQFCE NLNELPSGEL PQI // ID K4CQG0_SOLLC Unreviewed; 1072 AA. AC K4CQG0; DT 28-NOV-2012, integrated into UniProtKB/TrEMBL. DT 28-NOV-2012, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Solyc09g007710.2.1}; OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; OC Solaneae; Solanum; Lycopersicon. OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc09g007710.2.1, ECO:0000313|Proteomes:UP000004994}; RN [1] {ECO:0000313|EnsemblPlants:Solyc09g007710.2.1} RP IDENTIFICATION. RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc09g007710.2.1}; RG EnsemblPlants; RL Submitted (APR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; K4CQG0; -. DR PaxDb; K4CQG0; -. DR EnsemblPlants; Solyc09g007710.2.1; Solyc09g007710.2.1; Solyc09g007710.2. DR Gramene; Solyc09g007710.2.1; Solyc09g007710.2.1; Solyc09g007710.2. DR eggNOG; ENOG410IKCM; Eukaryota. DR eggNOG; ENOG4112BMQ; LUCA. DR InParanoid; K4CQG0; -. DR OMA; WHGFPLR; -. DR OrthoDB; EOG09360336; -. DR Proteomes; UP000004994; Chromosome 9. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS51450; LRR; 4. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000004994}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000004994}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 10 148 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1072 AA; 122278 MW; 44DAD0209D077922 CRC64; MSHAFSSKIC KYDVFLSFRG EDTRRTFVSH LYKALEQSGI RIFKDDERLE RGKPIFDELL KAIEESKIAI VIFSKSYASS RWCLEELAHI IKCRNELELI VIPVFYDVTP SDVRHQNPPF ADSFLQYMKD DMEKVQRWRA AFVEAGKISG YHLLNFKHEA KFNKKLVEEV LELVKPTCMH LPGLVIGPNS HAAGVISLCE FYSSAGVCMF GIYGMGGIGK TTVAKAVYNQ IHRRYEGFSF VAHVRERSEN NMLHNLQKQL LSDVLKRDKF KVQYNVDKGK CLIQDRLGQR KVLIVLDDVD DMSQIKALAE ERSWFGSGST IIITTRSESL LDDVGVDYKY EVTRLDDFSS KRLFFCFHAF KNTTVPENLD HELVNNIASL GGGVPLALEV LGSLLHKKDD QTWRSTLESL KNLAHHTSIH KALKVSYDSL DDNSKEIFLD IACFFIEAQQ CFASLVLTAC GHSFNLGKGI LIGRCLMKIE QNQLWMHDLV RDMAREIVRQ ESVKEPHMRS RLWFHEDVRY VLEKNKGSDQ IEGISAIHPR VKDLTVGTKS FARMDRLKIF QAKGMNLTGS FKNLFEELRW LYWQNFPLKC LPTDIHPTKL VALDMQYSKY HGSLPLENLA YLNLSHCQRL KRTPDFSRAI SLETILFTGC SELGEIDSSI KYLVKLVYLN LEDCVSLKNL PNSICKLESL QHLDMSGCSG LQQLPADFGN LTNLRSLSLE GCNRSLKAQS WRTCILSHFP WAGSSSSRPE WLLPHSLSRL SHLTELNLKD CRLSEADIPT NLGSLTSLEY LDLGGNDFYT LPSSLFCDLY ELQCLVLDDC KNLQMLSLLP CNLLELHAND CSSIESLDMS NYRIMPQLHV SNCDRLSEIK GMETMENVEY VCMEHSRKMA RRFFDESFFQ LTGECDKDLP YPSSYYIAGS EVPEWFSNLN IGSNITLTMP PNIEHNFQGM ILWSIYKCKY NGVFQYGPII EVGDQTNKVT WVLGFPEITV TADNCSWVSF IPQDYFCPAL EGGEQITFSF SIREQGFTGL SVTKCGVHPV YATAGRALPK LQFRSNFEER RSICGDNHPL LK // ID K7FJ32_PELSI Unreviewed; 434 AA. AC K7FJ32; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Single Ig and TIR domain containing {ECO:0000313|Ensembl:ENSPSIP00000008042}; GN Name=SIGIRR {ECO:0000313|Ensembl:ENSPSIP00000008042}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008042, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000008042} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008042} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGCU01143113; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01143114; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01143115; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_006131712.1; XM_006131650.2. DR RefSeq; XP_006131713.1; XM_006131651.2. DR STRING; 13735.ENSPSIP00000008042; -. DR Ensembl; ENSPSIT00000008084; ENSPSIP00000008042; ENSPSIG00000007329. DR GeneID; 102450807; -. DR KEGG; pss:102450807; -. DR CTD; 59307; -. DR eggNOG; ENOG410IEXB; Eukaryota. DR eggNOG; ENOG410ZFDI; LUCA. DR GeneTree; ENSGT00840000129987; -. DR KO; K05169; -. DR OMA; EVEMNDG; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF325519; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006953; P:acute-phase response; IEA:Ensembl. DR GO; GO:0045079; P:negative regulation of chemokine biosynthetic process; IEA:Ensembl. DR GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0043433; P:negative regulation of DNA binding transcription factor activity; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 135 156 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 26 125 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 179 326 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 434 AA; 49200 MW; 6D0DCB2AD0891663 CRC64; MPHLNSHTDA FFTIRLAMSD LCSMSPEVLF PSRNQTLEPA LGSQVTLNCT MRLPFEQDCQ PVLRWMKDGD GLGNESSQYT CKLLNWYSDN ATETFVSSVL GVNLTSDEDY GVFACVVRNT TATFTLHRSE AAGHVSAVVA ALLVLGLLLL MVVIYAKCRL NMLLWYRNRY GELEINDGKL YDAYLSYANS PDDRKFVNFI MKPQLENRHG YKLFLDDKAI LPNSEPSADL IMNVSRCRRL IVVLSYAYLE QDWCNNSFRE GLWRLLELSQ RPIFIAFESQ YREIEHPAIH LLKQHKNAVT LLLWRTGSMT PSSDFWKELC LALPRKVSYQ RTMGDPQTQL QEDKDPMLIL HSSYLEYKGD SHLEGDLGVS GSVLRGPPPP RMMGPEGPPA LAAGILEEVQ LEEGQKNEID ISDLGSRNYG ARTDFYCLVT EDDL // ID K7FUZ0_PELSI Unreviewed; 658 AA. AC K7FUZ0; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Interleukin 1 receptor accessory protein like 2 {ECO:0000313|Ensembl:ENSPSIP00000011850}; GN Name=IL1RAPL2 {ECO:0000313|Ensembl:ENSPSIP00000011850}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011850, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000011850} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000011850} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGCU01118490; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118491; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118492; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118493; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118494; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118495; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118497; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118498; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01118499; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 13735.ENSPSIP00000011850; -. DR Ensembl; ENSPSIT00000011907; ENSPSIP00000011850; ENSPSIG00000010635. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR OMA; ADDNKEY; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 329 350 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 18 104 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 132 200 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 211 319 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 372 531 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 658 AA; 75511 MW; 4DF7501729F9A131 CRC64; DGCIDWSVDL KTYMALAGEP VRVKCALFYS YIRTNYSMAQ STGLRLMWYK NKGDLEEPII FSEVRMSKDE DSIWFHSAEL EDSGFYTCVL RNSTYCMKVS MSLTVAENES GLCYNSQIRY LEKSEVTKRK IISCPDIEDY KTSTQEPEVV WYKECKPKMW RSIIIQKGNT LLIPEVQEED GGNYTCELKF EGKLIRRTIQ LKVTALLTDK PPKPLFPVEN QPSIIDVQLG NPLNIACKAF FGFSGESGPM IYWMRGEKFI EELEGHIREG EIRLLKEHLG EKEVELTLTF DAVGEPDLAN YTCHVENRNG RKHASVLLRK KDLIYKIELA GGLGAILLLL ILLVTVYKCY NIELMLFYRQ NFGGDESMDD HKEYDAYLSY TKVDPDALDC DNNEEEQFAL EILPDVLEKH YGYKLFIPDR DLIPSGTYIE DLTRCVEQSR RLIIVLTPDY VLRRGWSIFA MENKLHNMLV SGEIKVILIE CVDLKGKVNY HEVESLKHTI KVLSVVKWKG PKSSKLNSKF WKHLVYEMPA KKKEILSRRQ VLDSAEQGLF GDLQTVPSIS MTGASSTLEA SQADIADYHQ TDSTQTRHYC RGYEYDMSAA TLPIASISNH HTYCNIPLTL LNGQLPLNNT MKDTQEFHRN NPLLPLSSRE LSFTSDIW // ID K7G218_PELSI Unreviewed; 1043 AA. AC K7G218; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000014329}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014329, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000014329} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014329} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGCU01061617; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 13735.ENSPSIP00000014329; -. DR Ensembl; ENSPSIT00000014397; ENSPSIP00000014329; ENSPSIG00000012812. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR OMA; KHLYGWD; -. DR OrthoDB; EOG091G0BWK; -. DR TreeFam; TF325595; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 30 {ECO:0000256|SAM:SignalP}. FT CHAIN 31 1043 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003906052. FT DOMAIN 883 1030 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1043 AA; 117123 MW; 6487338CC60D71E8 CRC64; TLLLCFLVPQ VSMLLWRVCL LAQGLLGAGA LFPSYPPCAN SKDGKNVDCS LRSLTLVPDI RSSSVTSLNL DSNFLALLAN GSFQGVPCLR DLSLSWNCMP GQLRKAHAVC QLVIQPGALT VLRHLTNLSL AGNSLSVLPP LPCTLRFLDL SYNNILRLGP RSLVELSHVS ELLLGNNCYY RNPCGSSVSL ARDAFLPLTS LRRLSLKFNN MTATPQGLPP TLHQLDLSEN KIAHVSHLEN LTSLRSLNLE WNCQRCDHAA QPCFPCPGNK ALTFEQDAFQ NLAQLRSLNL RGNSLQDLNA SFFSSLRNLE TLDLSDNFLT CAIRHGTFFS VLSSVQTLNL GYNYQSLVTF ENLTLSDSFG QMTSLKNLII NGYFFRHLAE DGIKPLFNLS NLETLQFRTN FIRNVNLSLF SKCRTLTFIS LSQNNIVFSP PCERGGNGAG TGPRGLSHDG TLVGNPRRWA EPKGRAEAMV RDSQSSHANL PAGVRCSKTL DLSFNSIHSI EPAQFQGLEA IDCLNLSSNY ISQSLNGSQF LPLRSLKLLD LSHNRFDLYY DSALQEVCQL VVLNLSNNQF HFTIKGLGHK FEFLKNLTNL KFLNLDNNQI GIRISKHLES QSLRLPLGQN GKADIMWMSG RNTYLEFFVK LPSLRLLDIS FNNLDSIPAQ VIETLPGSLR KLSIACNNLY DFPWDKMEKL SSLEFLDLSY NALETLLVVG RGSFGKNLTT LDLSYNKIKS LQEAFFSHAS SLHFLSLNHN KIQMVDESSF PKALLQSLQQ LDVSSNPLRC TCAAHWFLTF LKSTSITIDH FSTSMQCDLP ESKRGQPLLS MDPRSCQDIY GHLSFLCSSL LVTLVTVLPV LHKLYGWDLW YVSHLCLATL RQGYAQVATA SREEYDAFVA FDAQHSLVAD WVYNEMVPQL EEKGRRRFKL CLEERDWTVG GSRIENLCDS IYKSRKTIFI LGREGFGSGF LRHTFLLSQQ RLLDEKVDVL LLVLLDPAMK MSRFLLARRR LCGRTVLDWP CNPFAQPYFW HCVRARLACE VHPFDASHLR RGV // ID K7GF83_PELSI Unreviewed; 669 AA. AC K7GF83; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSPSIP00000018944}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSPSIP00000018944}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000018944, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000018944} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000018944} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGCU01195619; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195620; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195621; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195622; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195623; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195624; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195625; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195626; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195627; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01195628; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 13735.ENSPSIP00000018944; -. DR Ensembl; ENSPSIT00000019030; ENSPSIP00000018944; ENSPSIG00000016810. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 333 354 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 80 205 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 215 323 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 376 535 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 669 AA; 76988 MW; DA54C0CC10F99CE6 CRC64; ADGCTDWSVD YKKYQVLMGE PVRIKCALFY GYIRANYSLA QSAGLSLMWY KSSGPGDFEE PIAFDGTRMS KEEDSIWFRP TVVQDSGLYA CVIRNSTYCM KVSISLTVGE NDTGLCYHSK MKYFEKAELS KSKEISCPDT EDFLSPYKEP EILWYKECKV KTWRPSIVFK RDTLIIREVR EDDIGNYTCE LKYGLFVVRR TTELTVTAPL TDKPPKLLHP LESKLTIQFS VTGNSANLTC RAFFGYSGDV SPLIYWMKGE KFIEDLDENR VWESDIRVIK EHLGEQEVSI SLILDSVEEG DLGNYSCYVE NGNGRRHASI LLHKRELMYT VELAGGLGAI LLLLVCLVTV YKCYKIEIML FYRNHFGAEE LDGDNKDYDA YLSYTKVDPD QWNQETGEEE RFALEILPDM LEKHYGYKLF IPDRDLIPTG TYIEDVARCV DQSKRLIIVM TPNYVVRRGW SIFELETRLR NMLVTGEIKV ILIECSELRG IMNYQEVEAL KHTIKLLTVI KWHGPKCNKL NSKFWKRLQY EMPFKRIEPI THEQVLDVSE QGPFGELQTV SAISMAAATS TALATAHPDL RSTFHNTYHS QMRQKHYYRS YEYDVPPTGT LPLTSMGNQH TYCNIPMTLI NGQRPQTKTN REQNPDEAHT NSAILPLLPR ETSISSVIW // ID K7GGG6_PELSI Unreviewed; 547 AA. AC K7GGG6; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000019377}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019377, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000019377} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019377} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGCU01153448; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01153449; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01153450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7GGG6; -. DR STRING; 13735.ENSPSIP00000019377; -. DR Ensembl; ENSPSIT00000019468; ENSPSIP00000019377; ENSPSIG00000017180. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR OMA; QKVGLHD; -. DR OrthoDB; EOG091G03IT; -. DR TreeFam; TF325519; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 547 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003902898. FT TRANSMEM 332 354 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 25 113 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 136 214 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 229 321 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 376 534 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 547 AA; 62500 MW; B290B15BA4BB4FBA CRC64; IMVAAVFTCS VILVFLSSVK ASTCPTRVFN SVFVLVGEPL IIDCLLDKTP HMNYNLTWYK SGRKMLVTQV KHSRIHQHEN MLWFVPATLE DSGSYECVIW NLTSCNKIYF NITVFKNTAG LCFNGNYLYP QEVPASSSVK IVCPYLDFFR DEKNTSLVHW YKECNLTKNE RFTSRNDDLI ITNANVNDSG NYLCKMTYKY MGKEYNISRN INVTVIETPP NKRTEILYPR NNTIEVELGS NVIVDCNVSS AKDISVGISW RVNNTLVNYS FMGRVQEGNQ IDSFPDGYLF STVTLNITEV KQEDYGRHFV CFAGEVAAYI ALRQPVQNFQ GYLIGGLLAS VFVTVVAILI YKFFKIDIVL WYRKSCHPFM SKEDGKIYDA YVLYPKISSV DSISTADNFV LKMLPEVLER KCGYNLFILG RDDLPGKAVI NVVDETIKQS RRLIIVLAPE SSSCGLLDNI SEQQLAMYNA LIQDGIKVIL IELDKIKDYT NMPESIKYIK QKHGAIRWKG DFTEKSYSTN TKFWKNVRYR MPPRHLTSSE LHLLPAS // ID K7GGK1_PELSI Unreviewed; 436 AA. AC K7GGK1; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPSIP00000019412}; OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae; OC Pelodiscus. OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019412, ECO:0000313|Proteomes:UP000007267}; RN [1] {ECO:0000313|Ensembl:ENSPSIP00000019412} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17381049; DOI=10.1080/10425170600760091; RA Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.; RT "The complete mitochondrial genome of the Korean soft-shelled turtle RT Pelodiscus sinensis (Testudines, Trionychidae)."; RL DNA Seq. 17:471-483(2006). RN [2] {ECO:0000313|Proteomes:UP000007267} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267}; RG Soft-shell Turtle Genome Consortium; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019412} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGCU01153452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01153453; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01153454; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01153455; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGCU01153456; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; K7GGK1; -. DR STRING; 13735.ENSPSIP00000019412; -. DR Ensembl; ENSPSIT00000019503; ENSPSIP00000019412; ENSPSIG00000017235. DR eggNOG; ENOG410IQBC; Eukaryota. DR eggNOG; ENOG410Z3W1; LUCA. DR GeneTree; ENSGT00760000119071; -. DR OMA; IQDYEKM; -. DR OrthoDB; EOG091G03IT; -. DR TreeFam; TF325519; -. DR Proteomes; UP000007267; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007267}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007267}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 208 230 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 86 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 254 411 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 436 AA; 50050 MW; BFF73945C217327F CRC64; MSIGETGGKI TCPDLEYFKD ENNTAPEIQW YKECKPGLLD NHRFHSPKNE NSLTIKNATI HDKGNYTCQT TYIYMGKQHN VSRTINVDIE EGPKNTPPEI IYPKNHSIEV KLGSHVIMDC NISSSIGSVT PYWQVNDMDV NEFDASYQEE FYEKSSQGSG FIIGTRFNIS KVKRKDYFHK FVCHVLHPYG EAGAYVVLKY PAPNTQGYLI GGLVSLVFVI VVAVFVYKLF KIDIVLWYRN YCHHFLSKEV SDGKIYDAYV LYPKNRVSCL YSPDIFALKI LPEVLERQCG YNLFIFGRDD LPGQAVINVA DEKISQSRRV IIVLVPDSSC YSVLEDSSEQ QLAVYNAIIR DGIKVILIEL DKIKDYTNMP ESIKYIKQKQ GVIKWKGDFT ERSHSARTTF WKNVRYQMPP RQTLSPSELR LLPPTFNSPH TITLER // ID K7GSL5_PIG Unreviewed; 230 AA. AC K7GSL5; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 2. DT 28-MAR-2018, entry version 31. DE SubName: Full=Interleukin 1 receptor accessory protein like 2 {ECO:0000313|Ensembl:ENSSSCP00000030902}; GN Name=IL1RAPL2 {ECO:0000313|Ensembl:ENSSSCP00000030902}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000030902, ECO:0000313|Proteomes:UP000008227}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00000030902, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000030902}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSSSCP00000030902} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AEMK02000120; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9823.ENSSSCP00000030902; -. DR PaxDb; K7GSL5; -. DR Ensembl; ENSSSCT00000034930; ENSSSCP00000030902; ENSSSCG00000012545. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; K7GSL5; -. DR OrthoDB; EOG091G0GXW; -. DR TreeFam; TF333913; -. DR Reactome; R-SSC-388844; Receptor-type tyrosine-protein phosphatases. DR Proteomes; UP000008227; Chromosome X. DR Bgee; ENSSSCG00000012545; -. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF01582; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000008227}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}. FT DOMAIN 1 103 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 230 AA; 26226 MW; D7AB814C3C797011 CRC64; MMKLPTCVEQ SRRLIIVLTP DYILRRGWSI FELESRLHNM LVSGEIKVIL IECTELKGKV NCQEVESLKR SIKLLSLIKW KGPKSSKLNS KFWKHLVYEM PIKKKEMLSR CHVLDSAEQG LFGELQPIPS IAMTSTSASL VSSQADLPDF HHSDSMQMRH CCRGYKHEMP TTTLPVPSLG NHHTYCNLPL TLLNGQLPIN NALKDTQEFH RNSSLPPLSS KELSFTSDIW // ID K7IRA7_NASVI Unreviewed; 1012 AA. AC K7IRA7; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:NV11600-PA}; OS Nasonia vitripennis (Parasitic wasp). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Terebrantes; OC Chalcidoidea; Pteromalidae; Pteromalinae; Nasonia. OX NCBI_TaxID=7425 {ECO:0000313|EnsemblMetazoa:NV11600-PA, ECO:0000313|Proteomes:UP000002358}; RN [1] {ECO:0000313|EnsemblMetazoa:NV11600-PA} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AsymCX {ECO:0000313|EnsemblMetazoa:NV11600-PA}; RX PubMed=20075255; DOI=10.1126/science.1178028; RG Nasonia Genome Working Group; RA Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J., RA Colbourne J.K., Werren J.H., Richards S., Desjardins C.A., Niehuis O., RA Gadau J., Colbourne J.K., Beukeboom L.W., Desplan C., Elsik C.G., RA Grimmelikhuijzen C.J., Kitts P., Lynch J.A., Murphy T., Oliveira D.C., RA Smith C.D., van de Zande L., Worley K.C., Zdobnov E.M., Aerts M., RA Albert S., Anaya V.H., Anzola J.M., Barchuk A.R., Behura S.K., RA Bera A.N., Berenbaum M.R., Bertossa R.C., Bitondi M.M., RA Bordenstein S.R., Bork P., Bornberg-Bauer E., Brunain M., RA Cazzamali G., Chaboub L., Chacko J., Chavez D., Childers C.P., RA Choi J.H., Clark M.E., Claudianos C., Clinton R.A., Cree A.G., RA Cristino A.S., Dang P.M., Darby A.C., de Graaf D.C., Devreese B., RA Dinh H.H., Edwards R., Elango N., Elhaik E., Ermolaeva O., Evans J.D., RA Foret S., Fowler G.R., Gerlach D., Gibson J.D., Gilbert D.G., RA Graur D., Grunder S., Hagen D.E., Han Y., Hauser F., Hultmark D., RA Hunter H.C. IV, Hurst G.D., Jhangian S.N., Jiang H., Johnson R.M., RA Jones A.K., Junier T., Kadowaki T., Kamping A., Kapustin Y., RA Kechavarzi B., Kim J., Kim J., Kiryutin B., Koevoets T., Kovar C.L., RA Kriventseva E.V., Kucharski R., Lee H., Lee S.L., Lees K., Lewis L.R., RA Loehlin D.W., Logsdon J.M. Jr., Lopez J.A., Lozado R.J., Maglott D., RA Maleszka R., Mayampurath A., Mazur D.J., McClure M.A., Moore A.D., RA Morgan M.B., Muller J., Munoz-Torres M.C., Muzny D.M., Nazareth L.V., RA Neupert S., Nguyen N.B., Nunes F.M., Oakeshott J.G., Okwuonu G.O., RA Pannebakker B.A., Pejaver V.R., Peng Z., Pratt S.C., Predel R., RA Pu L.L., Ranson H., Raychoudhury R., Rechtsteiner A., Reese J.T., RA Reid J.G., Riddle M., Robertson H.M., Romero-Severson J., RA Rosenberg M., Sackton T.B., Sattelle D.B., Schluns H., Schmitt T., RA Schneider M., Schuler A., Schurko A.M., Shuker D.M., Simoes Z.L., RA Sinha S., Smith Z., Solovyev V., Souvorov A., Springauf A., RA Stafflinger E., Stage D.E., Stanke M., Tanaka Y., Telschow A., RA Trent C., Vattathil S., Verhulst E.C., Viljakainen L., Wanner K.W., RA Waterhouse R.M., Whitfield J.B., Wilkes T.E., Williamson M., RA Willis J.H., Wolschin F., Wyder S., Yamada T., Yi S.V., Zecher C.N., RA Zhang L., Gibbs R.A.; RT "Functional and evolutionary insights from the genomes of three RT parasitoid Nasonia species."; RL Science 327:343-348(2010). RN [2] {ECO:0000313|EnsemblMetazoa:NV11600-PA} RP IDENTIFICATION. RG EnsemblMetazoa; RL Submitted (MAR-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; K7IRA7; -. DR STRING; 7425.NV11600-PA; -. DR EnsemblMetazoa; NV11600-RA; NV11600-PA; NV11600. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; K7IRA7; -. DR OMA; ICIHIRD; -. DR PhylomeDB; K7IRA7; -. DR Proteomes; UP000002358; Chromosome 2. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 16. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002358}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000002358}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 1012 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003904887. FT TRANSMEM 799 824 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 851 990 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1012 AA; 114909 MW; 1F73B31094DCDD7D CRC64; MARFALPLAV ILIFAVSSTS GQFSCPKHLP CYCFVSAMNE YKIHCAINST ANSAFDITIQ PGNKVRIQCK NSPDWSQFLL GSAIVVGPVV KFEFDSCAAP GPMYSAKIVD WQINALGVEY LKYEDFSAPL TVQDFNVFTQ LKHLVLSYNK LGQLQRDLLR GLPNLKRLEL KNTSIAEIPQ GFFDNSSSLR TLELNGNKLE SLAPGIFDRL KQIYSLNLGQ NNLHEFKPDV FHNLQNLTAL DIQLNNLKTL PANIFADLKS LEVIEFGGNN FISLPADLFQ YNPELKIVNH SNNTGNLTTL PGKLLFGFAN LKVVSLAHSG IHYLPEDLLW GSTSMIELNL NENYLKKLPT NLLKDAAELH TLSLSSNDQE FLEAGTFFNN KKLIKLDLSK NHLTFIKEYT FDGLEYLQEL NMEHNDLTYI NVDAFASLQQ LKIGKFANNK LTLRTDVFDL FGQISPFHAC ASLEVLDLAH NNIEEIFSDW MVTSTNLRTV DLSYNKFEKL QAADFQFTSN RIKVHLSHNN IQLLNLARLE YFSTNQIADK SNVMHPRNAI VFLSSNPIQC DCELYDLVRY LNNQMDLQAQ EFVKLNVKNM TCDGPEHMAG LVVEQLETSA IKCRVQSAKA QKDDPCAANS TCDCWMTPSD NSLLLDCARR NLTSPPAWIN TRGYDCVELD LSRNKLRSGP NMSAKGYDKV VSLNLAENKI TDVEMNLITP NLKILNLEGN NLTSLNSEVL KKLFDVSNIS QLTLRNNPWI CNCSSRDLLS NFQMGYKQIS DFVNITCQNS IVSLSRLTID ELCQFSDNLI IIAGSLASLF VLLMSCVATL YFCFGKQIKI WLYSKNACLC LVTEREVDKG KIYDAFVSYS HKDEEFVVKE LVTKLEEGPR PYKICIHIRD WLAGECIPVQ ISRSVEDSRR TINVLSPNSI ESVWARMEFQ TAYKRALSEK RARVIIVVYG EIGHIYDLDT DLRSYLTMNT YVKWGDPWFW KKLKYALPHS KKVLKDRRHF RTHYVKYINC IG // ID L5M0T5_MYODS Unreviewed; 583 AA. AC L5M0T5; DT 06-MAR-2013, integrated into UniProtKB/TrEMBL. DT 06-MAR-2013, sequence version 1. DT 28-FEB-2018, entry version 27. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:ELK32289.1}; GN ORFNames=MDA_GLEAN10013331 {ECO:0000313|EMBL:ELK32289.1}; OS Myotis davidii (David's myotis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK32289.1, ECO:0000313|Proteomes:UP000010556}; RN [1] {ECO:0000313|Proteomes:UP000010556} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23258410; DOI=10.1126/science.1230835; RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X., RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., RA Zhou P., Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., RA Sun X., Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., RA Wang L.F., Wang J.; RT "Comparative analysis of bat genomes provides insight into the RT evolution of flight and immunity."; RL Science 339:456-460(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB105440; ELK32289.1; -; Genomic_DNA. DR RefSeq; XP_006761182.2; XM_006761119.2. DR GeneID; 102751415; -. DR KEGG; myd:102751415; -. DR CTD; 8807; -. DR KO; K05174; -. DR Proteomes; UP000010556; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000010556}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ELK32289.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000010556}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 583 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003970742. FT TRANSMEM 358 385 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 148 237 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 250 352 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 405 561 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 583 AA; 65361 MW; 8CF832F02D9F1FD5 CRC64; MLCLGWIFLW FVTGERTKGF NISGCSIKNF LWMYSAESAE EFVLFCDLAE AWKPRSYHRH PPSPAQGPER RPCHDREGLS DVQWYLQPRE GGALKEITSN QSHLLLDKTA LRFLTAERSH AGSYICRPRM RSRGDEACCV KMDLDVQPQA DLSCARREPR TRYLRLGSTG SIHCPSLGCQ GGAPSPEMTW YQNGRLLSAQ RSNPLPLDVI YDFHQGTYAC DYTQAGGAGP RTVRAVVHVK TIVRNTTLKP DILEPVKDTL EVELGKPLTL NCTAQFGFEE HFKPVLRWYS KNSGQELEIP TKEGRSVKAT VEAEVIQRTV HLESVAQSDL HKTFICFAQN SLGNSTQPLQ LRGRKGVVFL YVLLGTVAAL VGALAAGVLL FTYWIEVVLL CRTCQDKDET LGDKKEFDAF ISYAKGSASE SEPASPVSED CLALKLFPEV LENKYGYTLC LLERDVAPGG VYTEDIVSII KKSRRGIFIL SPNYVNGPSV FELQAAVSLA LDDQTLKLIL VKFCPFQEPE SLPDLVRKAL RVLPIVTWRG LKSAPPNSRF WTRMRYHMPM KNPTGLPWGH LRVISRAFSL GRQ // ID L8YB37_TUPCH Unreviewed; 735 AA. AC L8YB37; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 28-FEB-2018, entry version 18. DE SubName: Full=Interleukin-1 receptor-like 2 {ECO:0000313|EMBL:ELV11566.1}; DE Flags: Fragment; GN ORFNames=TREES_T100005910 {ECO:0000313|EMBL:ELV11566.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11566.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB365080; ELV11566.1; -; Genomic_DNA. DR InParanoid; L8YB37; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 2. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 5. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 2. DR Pfam; PF01582; TIR; 2. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 2. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 2. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ELV11566.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 735 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003998496. FT TRANSMEM 229 250 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 518 541 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 46 115 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 121 213 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 264 370 TIR. {ECO:0000259|PROSITE:PS50104}. FT DOMAIN 398 486 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 563 721 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:ELV11566.1}. SQ SEQUENCE 735 AA; 85220 MW; 103F375C940C63A9 CRC64; QENMKVLLRL ICFIALLMSS LEADNCMERE SIIHVVSSAD EIDVRTCPLN PNEDKGTISW YKNDSKIPLP MDPVSRIRQR EDNLWFIPAK VEDSGYYYCV VRNASHCLRI KVTVEFVEND PDLCFNTQAR FAQRLPVAGD GKIVCPYLDY FKDENNELPK IQWYKDCKPF PLDETCFSGV ADKLIVSNVA EEHRGNYTCR TSYTYLGKQY HVSRVIELIT VVPDFQNHVI GAFVMLTVII ICSVFIYKIF KVDIVLWYRD SCYDFLPPKD IVEVTNANIK KSRRLIIILV REILGFGWLG NSSEEQIAMY NALIQDGIKV VLLELEKIQD YEKMPESIQF IKQKHGAIRW SGDFREGPQT VKTRFWKNVR DRDSCYRIQV NLTVFEKYWC DPTRRNPPHL SDEYKQILHV GNDSLTCHLH FPKSYIVDSV KWYKDCKEIK EKRFTPLRVM LLVNNVTAKD RGNYACQATL THLGKRYMVL NSITVNVTKR IDNGGRIPKI IYPKNNSIEV QPVPDFRAYL IGGFIALTVT TLSVVCVYNL FKIDIVLWYR SAFPSTRNTE DGKLYDAYVL YPKPQRESQS HDVEKLVLEI LPEVLERQCG YKLFIFGRDE FPGQAVATVI DDNIKLCRRL IVIIVPESLS FSLLKNMSEE QIAVYNALIQ DGMKVILIEL ERIEDYTAMP ESIQYIKQKH GSIQWSGDFT EQSQCAKTKF WKRVRYHMPP QGCSASSDQL LKHKS // ID L9JCG1_TUPCH Unreviewed; 483 AA. AC L9JCG1; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 25-OCT-2017, entry version 16. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:ELW48310.1}; GN ORFNames=TREES_T100019800 {ECO:0000313|EMBL:ELW48310.1}; OS Tupaia chinensis (Chinese tree shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia. OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW48310.1, ECO:0000313|Proteomes:UP000011518}; RN [1] {ECO:0000313|Proteomes:UP000011518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Zhang G., Fan Y., Yao Y., Huang Z.; RT "Genome of the Chinese tree shrew, a rising model animal genetically RT related to primates."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB321064; ELW48310.1; -; Genomic_DNA. DR InParanoid; L9JCG1; -. DR Proteomes; UP000011518; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011518}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ELW48310.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000011518}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 141 165 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 34 137 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 190 349 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 483 AA; 55406 MW; F17D26AA269B0B2F CRC64; MSKAVLYGSQ IEATTMSTHN YGTELRNHIT AFVPENLTTK CENRVACDSA NLTCRAFFGY SGDVSPLIYW MKGEKFIEDL DENRVWESDI RILKEHLGEQ EVSISLIVDS VEEGDLGNYS CYVENGNGRR HASVLLHKRE LMYTVELAGG LGAILLLLVC LVTIYKCYKI EIMLFYRNHF GAEELDGDNK DYDAYLSYTK VDPDQWNQET GEEERFALEI LPDMLEKHYG YKLFIPDRDL IPTGTYIEDV ARCVDQSKRL IIVMTPNYVV RRGWSIFELE TRLRNMLVTG EIKVILIECS ELRGIMNYQE VEALKHTIKL LTVIKWHGPK CNKLNSKFWK RLQYEMPFKR IEPITHEQAL DVSEQGPFGE LQTVSAISMA AATSTALATA HPDLRSTFHN TYHSQMRQKH YYRSYEYDVP PTGTLPLTSI GNQHTYCNIP MTLINGQRPQ TKSSREQNPD EAHTNSAILP LLPRETSISS VIW // ID M1BA09_SOLTU Unreviewed; 974 AA. AC M1BA09; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 28-FEB-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:PGSC0003DMT400040528}; GN Name=107058378 {ECO:0000313|EnsemblPlants:PGSC0003DMT400040528}; OS Solanum tuberosum (Potato). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; OC Solaneae; Solanum. OX NCBI_TaxID=4113 {ECO:0000313|EnsemblPlants:PGSC0003DMT400040528, ECO:0000313|Proteomes:UP000011115}; RN [1] {ECO:0000313|EnsemblPlants:PGSC0003DMT400040528} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. DM1-3 516 R44 RC {ECO:0000313|EnsemblPlants:PGSC0003DMT400040528}; RX PubMed=21743474; DOI=10.1038/nature10158; RG The Potato Genome Sequencing Consortium; RT "Genome sequence and analysis of the tuber crop potato."; RL Nature 475:189-195(2011). RN [2] {ECO:0000313|EnsemblPlants:PGSC0003DMT400040528} RP IDENTIFICATION. RC STRAIN=DM1-3 516 R44 {ECO:0000313|EnsemblPlants:PGSC0003DMT400040528}; RG EnsemblPlants; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR RefSeq; XP_015159499.1; XM_015304013.1. DR ProteinModelPortal; M1BA09; -. DR STRING; 4113.PGSC0003DMT400040528; -. DR EnsemblPlants; PGSC0003DMT400040528; PGSC0003DMT400040528; PGSC0003DMG400015681. DR GeneID; 107058378; -. DR Gramene; PGSC0003DMT400040528; PGSC0003DMT400040528; PGSC0003DMG400015681. DR KEGG; sot:107058378; -. DR eggNOG; ENOG410IGK5; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; M1BA09; -. DR OMA; SESNSQY; -. DR OrthoDB; EOG093600G2; -. DR Proteomes; UP000011115; Unassembled WGS sequence. DR ExpressionAtlas; M1BA09; baseline. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011115}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000011115}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 21 160 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 974 AA; 110671 MW; 0A1A1BFDEDC7D319 CRC64; MASSSSPSES NSQYSCPQQK CKYDVFLSFR GLDTRNNFTS HLYKALTNRV ILTFLDDESL ESGDTLWIEL EKAMEESQVA VIIFSKNYAT SSWCLDELVK IMKCKEDNGQ TVIPVFYDVD PSHVRYQSES FKEAFARHES RYTDEKIEGW RTALIAAANI KGHNIRDRNE AHFIEDLVNE IWPKLCTTSL SSLKDIVGID AHLEKVNSLL EMTINDVRRV WIWGIGGVGK TTIARAIFDI HSSKFDGACF LPVSKENKHE IHSLQSILLS KLAGGKENCV LDKEDGRDWM ARRLCRKKVL VVLDNIDHDD QLKYLAGDLG WFGNGSRIIA TTRDRHFTRK TDAVYRVTTL LEHDAVKLFN QYAFKDEVPD KCFEEMTLEV VRHAQGLPLA LEVWGSSFRE KNIIRWRSAV NGLKKNFNSK ILGILKVSYD GLEPKEQEIF LDIACFLKGR EQTKIKEILE SCDFEAADGL GELIDKSLVF ISEKDTIEMH DLIQKMGKHI VTVQREELSR LWLTEDFEEF SKASIQGARS IEAIWVQEIQ YLSFRENAMN AVKNLRILYI NGFNTHDGSN DQYLPSKLRW FDCCKYPWES LPEKFDPDKL VHLDLQQSSL LHLWTETKKF PSLRRLVLSG CENLRGTPDF TDMPNLEYLG LEECSNLTTV HHSLKDSKKL KKLNLRDCKR LATFEFVSGV SLEYLDIQGC SGLEKFPSIK EKGKRKKRIH VQCSGLSELP SAMIEHQSSL TNLDLSGMKN LEKLSRSIGK LKHLVMLKVS YCSKLSSLPK EIGHLENLEE LDASYTLISQ PPSSIFRLNK LKLLTFAKQK SEAGLEDGVH FVFPPVNGGL HSLEDLDLSY CNLLDGGLPE DIGSLSSLKE LNLSYCNIID GGLPDDIGSL SSLKKLNLRG NNFEHLPQGM ARLGSLQSLN LLDCKSLTQL PEFIPQLGTI YADRRNDSIY NSLFHNISSS SVPGSRSLLR RFEV // ID M3XAS7_FELCA Unreviewed; 870 AA. AC M3XAS7; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-MAR-2018, entry version 46. DE SubName: Full=Toll-like receptor 4 {ECO:0000313|Ensembl:ENSFCAP00000023731}; GN Name=TLR4 {ECO:0000313|Ensembl:ENSFCAP00000023731}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023731, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000023731, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023731, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000023731} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023731}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000023731} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023731}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AANG03345720; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSFCAT00000028421; ENSFCAP00000023731; ENSFCAG00000024741. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR OMA; EDWVRNE; -. DR OrthoDB; EOG091G01RC; -. DR Proteomes; UP000011712; Chromosome D4. DR Bgee; ENSFCAG00000024741; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; IEA:Ensembl. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl. DR GO; GO:0005102; F:receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl. DR GO; GO:0014002; P:astrocyte development; IEA:Ensembl. DR GO; GO:0002322; P:B cell proliferation involved in immune response; IEA:Ensembl. DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl. DR GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IEA:Ensembl. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl. DR GO; GO:0032497; P:detection of lipopolysaccharide; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0050702; P:interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl. DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl. DR GO; GO:0032707; P:negative regulation of interleukin-23 production; IEA:Ensembl. DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl. DR GO; GO:0002537; P:nitric oxide production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl. DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl. DR GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl. DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl. DR GO; GO:0070430; P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; IEA:Ensembl. DR GO; GO:0070434; P:positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; IEA:Ensembl. DR GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; IEA:Ensembl. DR GO; GO:0010572; P:positive regulation of platelet activation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl. DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 9. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 870 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014167447. FT TRANSMEM 671 694 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 710 856 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 870 AA; 99914 MW; 4C840B9A6AF5835C CRC64; MMPPTRLAGT LIPAMAFLSC LRPESWDPCV ERPSIIPGSR IDLYHLCAKG TILGKRNFQA WFTVHYTSVV PNITYQCMDL NLHKIPDNIP SSTKDLDMSF NPLRNLGSHS FSNFPELQVL DLSRCEIQII EDDAYQGLNH LSILILTGNP IQRLFPGAFS GLSSLQTLVA VETNIASLED FPIGHLKTLK ELNVAHNLIH SFKLPEYFSN MSNLEYLDLS NNKIQNIYHK DLQVLHQKPL LNLSLDLSLN PLDFIQPGAF KEVKLRELTL RSNFNSTDVM KASIQGLAGL QIHQLVLGEF KNERNLGRFD KSILEGLCNL IIEKFRIAYF DKFSEDAIDS FNCLANVSTI SLVHLYFKGL KQLPKNLGWQ RLELVNCEFE QFPTWKLDSL KELVFSANEV RNTFTQVKLE SLEFLDLSRN DFSLKSCCSE RDLGTTRLKH LDLSFNNIIT ISSNFLGLEQ LEYLDFQHSS LKQVSDFSVF LPLKNLRYLD ISYTHTQVAF HGIFNGLISL QILKMAGNSF QDNFLPNIFM ELTNLTILDL SDCQLEQVSQ VAFNSLPKLQ LLNMSHNHLL SLDTLPYEPL HSLQTLDCSF NRIVASKEQE LRHFPSNLSS LNLTRNDFAC VCEHQSFLQW VKDQRQLLVE VEQMVCAKPL DMQGMPMLNF RNATCQVRKT IITGSVFTVL LVFLVVVLVY KFYFHLMLLA GCKKYSRGES TYDAFVIYSS QDEDWVRNEL VKNLEEGVPP FQLCLHYRDF IPGVAIAANI IQEGFHKSRK VIVVVSQHFI QSRWCIFEYE IAQTWQFLSS RAGIIFIVLQ KLEKSLLRQQ VELYRLLNRN TYLEWEDSVL GRHIFWRRLR KALLDGKPRC PEGMADAEGS // ID M3Z4X4_MUSPF Unreviewed; 858 AA. AC M3Z4X4; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 44. DE SubName: Full=Toll like receptor 5 {ECO:0000313|Ensembl:ENSMPUP00000018636}; GN Name=TLR5 {ECO:0000313|Ensembl:ENSMPUP00000018636}; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; OC Mustelinae; Mustela. OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000018636, ECO:0000313|Proteomes:UP000000715}; RN [1] {ECO:0000313|Ensembl:ENSMPUP00000018636} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000018636}; RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S., RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., RA Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J., RA Walker B.J., Young S., Birren B., Lindblad-Toh K.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMPUP00000018636} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AEYP01103745; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_004781852.1; XM_004781795.2. DR RefSeq; XP_012906089.1; XM_013050635.1. DR RefSeq; XP_012906090.1; XM_013050636.1. DR RefSeq; XP_012906091.1; XM_013050637.1. DR STRING; 9669.ENSMPUP00000018636; -. DR Ensembl; ENSMPUT00000018908; ENSMPUP00000018636; ENSMPUG00000018756. DR GeneID; 101693476; -. DR CTD; 7100; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR InParanoid; M3Z4X4; -. DR OMA; KYDAYLC; -. DR OrthoDB; EOG091G030N; -. DR Proteomes; UP000000715; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027176; TLR5. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44698:SF2; PTHR44698:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000715}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000000715}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 858 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004045847. FT DOMAIN 691 827 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 858 AA; 96561 MW; 116F01AD2FDCFD5E CRC64; MGGYLDLLLG VVLVVSPVLT IPSCTSDGQR ALYRSCNLTQ VPPVPSTTQI LLLSFNYIRT VTTTSFPFLE QLQLLELGTQ FTPFTIGREA FRNLPNLRVL DLGKSQVDFL HPDAFQGLPR LQELRLFHCG LSDKTLKDGY FRNLESLSRL DLSKNQIQSL NLHPSFWELN SLKSIDFSLN QIPVVCEHEL QPLQGKTLSL LNLAANQLYS RGSMDWGACM NPFKNMVLET LDVSGNGWTA DITGNFSRAV SGSQISSLVL AHHIMGPGFG FQNIRDPNRD TFAGLARSTL LWLDLSYGFI FSLNFRVFEA LKDLKLLQLA HNKINRIAEE AFYGLDSLQV LNMSYNLLGE LYDSDFSGLR QVAYIDLQNN HIGIIQSQTF RFLKTLQTLD LRDNALKTIS FLPSLDTIFL GSNKLAALPD MELKASFIHL SENRLEDLDD LYFLLQVPNL QVLILNQNRF SSCSRARGPA GSLSLEMLFL GRNMLQLVWE TGFCWDVFKG LSRLRVLYLN NNYLTFIPPG ALGDLSALRG LDLSSNRLMA LAPGDLPANL EVLDVSRNQL LTLDPNLLAS LTAVDITHNK FICECDLRSL VVWLNQTNVT VFGSGADISC TYPNALAGTP LSSVSMEDCD EEEVLKALRL SLFVSSTVTL TLFLVTVFVS TKLRGLGFIC YRAACRLLPT VQAERHESKP YRYDAYLCFS GRDFAWVQRA LLRHLDAQYS AQNRFNLCFE ERDFVPGREH IANIQDAVWG SRKVVCLVSR HFLRDGWCLE AFAYAQSRCV SDADGALILV IVGSLSRFQL MKHRGIAGFV RKRHYLRWPE DLQDVGWFLH TLSQHILKRE KDTIRDGSIQ LQAVVTVS // ID M4A3R5_XIPMA Unreviewed; 715 AA. AC M4A3R5; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSXMAP00000009109}; OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; OC Poeciliinae; Xiphophorus. OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000009109, ECO:0000313|Proteomes:UP000002852}; RN [1] {ECO:0000313|Ensembl:ENSXMAP00000009109} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009109}; RA Walter R., Schartl M., Warren W.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSXMAP00000009109} RP IDENTIFICATION. RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009109}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGAJ01018214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01018215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01018216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01018217; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGAJ01018218; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005805061.1; XM_005805004.2. DR STRING; 8083.ENSXMAP00000009109; -. DR Ensembl; ENSXMAT00000009123; ENSXMAP00000009109; ENSXMAG00000009090. DR GeneID; 102234441; -. DR KEGG; xma:102234441; -. DR eggNOG; ENOG410IF3G; Eukaryota. DR eggNOG; ENOG4110Z8K; LUCA. DR GeneTree; ENSGT00760000119071; -. DR InParanoid; M4A3R5; -. DR KO; K05170; -. DR OMA; FPSESQM; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000002852; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002852}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002852}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 715 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004047481. FT TRANSMEM 361 382 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 6 130 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 162 232 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 242 350 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 404 578 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 715 AA; 82123 MW; ACEF88ED7D8C4677 CRC64; MKASIPLLIL LHALVVHCLK VVSKRGSVEG CTDWSVDYQK YKVLVGEPVR IKCALFYGYI RANYSHAQST GLSLMWYKSA VHGDFEEPIS FDGARMSKEE DSIWFRPAEL DDVGYYSCVL RNSTYCMKVS MSLIVAENDT DLCYNSKMRF FEKAELSKCK NITCPDIEDF IQPGVEPKIV WYKDCKPKQW RQTIERRRDT LFIKEVREDD IGNYTCEIPF GNFVVRRTTE LSVTAPVTDQ APKILFPSES QMSIIEMALG SPVNLTCSAF FGYNGDVSPL IYWKKEDNFI EDLDEERIQE SDIKTIREHL GEQEVSISLT IDSLEESDLG NYSCYVENSN GRRQANVKLI KKAELMYTVE LAGGLGAILL LLICLVTLYK CYRIELMLFY RNHFGSEDID GENKDYDAYL SYTKVDPDQW SQETREEERF ALEILPDVLE KHYGYKLFIP DRDLIPTGSF TNDHFQDDTR LLRAYIEDVA RCVDQSKRLI IVMTPSYVVR RGWSIFELET RLRNMLVTGE IKVILIECAE LRGIMNYQEV EALKHTIKML TVIKWRGPSS NKLTSKFWKQ LLYEMPFKRM EPLSISHEQV LDVSEQGAFG ELQTVSAISM AAATSTAMAT AHPDLRSTFH NSCHTQMRQK HYYRSYDYDL PPSGTLPPLS SLGNQHTYCN IPMTLINGQR PQSKSPRQQS VEEGHGNNAM LPLLPRETSI SSVIW // ID M4D1Z6_BRARP Unreviewed; 1184 AA. AC M4D1Z6; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra010496.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra010496.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra010496.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra010496.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra010496.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra010496.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 3711.Bra010496.1-P; -. DR PRIDE; M4D1Z6; -. DR EnsemblPlants; Bra010496.1; Bra010496.1-P; Bra010496. DR Gramene; Bra010496.1; Bra010496.1-P; Bra010496. DR InParanoid; M4D1Z6; -. DR OMA; WIWRISH; -. DR Proteomes; UP000011750; Chromosome A08. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 35 57 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 88 226 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1184 AA; 132442 MW; CB4EADB69AEC7590 CRC64; MLGRSTDYAG PQISCGKVIP MFHDGNFLSS SVNGITVPCC VSAAAICFYA LLGTVFFNRK SRSHQENKTM ASSSLTRLAP PSSLPPNCKH QVFPSFHGVD VLENFLSHIV KEFKSNAIDL FIDNNIERSK SIGPALIEAI RGSRVAIVLL SKNYASSTWC LNELVEIMEC REEVGQTVIT IFYQVNPTDI KKQKSYFGKV FRKTCKGKRN EEIQRWKHAL TDVAQIEGYH SINWKNESEM IEYIATDVSN KLNLSAPSSD FDGFVGMKSQ MVTMGPLLQL DSEEVRKIGI LGQPGIGKTT IARYIFNTYS REFQLSVFMD NIKRKYATTA CSDDYSVKLD LQKHFMSQLT NVTDINNFSH LGIAKHRLKD KKVLVVLDDV DRLVQVEAFA KETNWFGPGT RIIITSQDQR VLKASGINHI HKVNFPSDDE ALQMFCMYAF DQKYPKDGFE ELACEVVSLV GRLPLGLKVM GSYFRGSFEQ EWTEALPKLR THLDRDGEIA SILKFSYDSL CDEDKRLFLH IACFFNCEKV GIVEDCLAKC FSDVRHGRGV LAEKSLISIN MDWGTIEMTK LLVQLGRKIV REQSVNEPGK RQFLNDAIEI CEVLSDDRAD SSSVIGINVE TYEDVECTSE RAFERLYNLQ FLRILGKGVN PQSINHISQK LKVLIWLNSE MTCFPSNFNP KFLVKLEMMN SKLKKLWEET KPLNNLKWMN LSRSRRLEEL PDLSTATNLY DLDLSYCSSL VKLPSSIGNA INLQSLHLSF CSNLVEIPPS IGNAVNIKKI SLIHCSSLVE IPTSITTITS LTSLDISGCS SLMKLPDNIE TFTEPNHINL SGCSSLVEIP SSIVNAKNLQ KLDLSNCLSL VELPSSIGNA INLQKLNLSH CSSLVELPFS IGNATNLQEL NLSHCSSLVE LPSSIGNATN LEELNLSHCS SVVELPFSIG SAINLQKLDL SRCSSLVKLP SSIGNAINFH KLNLSDDWSS MVELPFFMRN LDRLLKCSKS EVLPADNNFQ SINLSDESSF KICPDQSSTI IRELDPWIWR ISHLRTLVLN GMKKLVSLPP LPDSLLFLDA EDCESLERLD CSFDNPDICL NFVNCFKLNQ EARDLISLTP TNGYAVFPGT EVPQCFTYRS SGSSLTVKLI QKSLGISTKF KACILSADLE GNNFPHWSQA SVCCGIIKIS RHLE // ID M4D289_BRARP Unreviewed; 1028 AA. AC M4D289; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra010589.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra010589.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra010589.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra010589.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra010589.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra010589.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 3711.Bra010589.1-P; -. DR EnsemblPlants; Bra010589.1; Bra010589.1-P; Bra010589. DR Gramene; Bra010589.1; Bra010589.1-P; Bra010589. DR InParanoid; M4D289; -. DR OMA; EISECAV; -. DR Proteomes; UP000011750; Chromosome A08. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 14 152 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1028 AA; 116480 MW; DC025032CCEC36A8 CRC64; MATSSLTLLA PRNWKYHVFP SFHGADVRTN FLSHVLKELR SKGIDSFIDN DIERSKLIGP ELVEAIRGSR IAIVLLSRNY ASSTWCLNEL VEIIKCREEF GQTVVPLFYE LDPTDVKKQT GDFGKVLGKT CRGKEKEDIQ RWKRALTEVA QIAGFHSANG ENEAELIEYI ATDVSNKLNL SAPCSDFDGL VGMESRMAEM RQVLQLDSDE VRKIGILGPP GIGKTTIARS LFNRHSQDFQ LSVFMDNIKR KFVIMACSDD YSVKLDFQKQ FMYQLTNETG IKIPHLGVAK DRLKDKKVLV ILDDVDQLVQ LEAMAKETSW FGPGSRIIIT TQDEKVLKAS GIDHIHRVNL PSDDEALQMF CMYAFDQKYP KDGFKKLACE VRNLVGGLPL GLRVMGSYFR GMSEQDWREA LPRLKIHLDR NGEISSILKF SYDALNDEDK RLFLHIACFF SGEPVEMVER CLEKCFQDVR QGLRVLSEKS LIYSKSGLIM MSTLLFQLGR QIVQKESISE PGKRQFLNDA IDIGEVLSDD KAGNSSVIGI DLEWNKDITW TSERAFERLS NLQFIRILGK GVNPLSMNYI SRKLKVLIWP MFPMPCFPSR FNPEFLVNLF VRNSNLEKLW EENKPLKNIK WMDLALSRRL KELPDLSTAI NLYYLDLSYC SSLVKLPSSI GNATNLEKLS LNYCSSLVKL PSSIGNAINL KTLSLKGCSS MVKLPSSIWN IVNLEELNLE NCSNLVELPS LLRSEIEKCT KSDCSRGSGK IIDHLPFIAG LLPNPQFEKN NTITYSESST NIEELDPWIG RILRLRRLVL SGMRKLVSLP QLPDSLLELD AENCESLERL HCSFPNQDIR LNFANCFQLN QEARDLIIQT PTNKYAVFPT EKVPICFSYR SSGSSLTVKL NRLPVGKSTK FKACILCSYD EENNFGLWET ASVFCTITFG GNASIACNKR VERVLPGNLC TFEVEVETEE VTSTKLVFDF GLLNLDFKTW KIKGCGILQL LEGPFEDFEP SDIELVREDD GDERLPLL // ID M4D290_BRARP Unreviewed; 983 AA. AC M4D290; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra010590.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra010590.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra010590.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra010590.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra010590.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra010590.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 3711.Bra010590.1-P; -. DR EnsemblPlants; Bra010590.1; Bra010590.1-P; Bra010590. DR Gramene; Bra010590.1; Bra010590.1-P; Bra010590. DR InParanoid; M4D290; -. DR OMA; IYHESST; -. DR Proteomes; UP000011750; Chromosome A08. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 3. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 29 167 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 983 AA; 110847 MW; E34DAD6E1B5991EA CRC64; MKSRSHQRNQ TAASSLTLLA PPSSLPHNSK HHVFPSFHGA DVRKTFLSHV LKEFRSKGID LFIDKDIERS KSIGPALIEA IRGSRIAIVL LSENYASSTW CLNELVEIIK CRQEFGQTVM PIFYQVNPTD IKKQKGYFGK VFRKTCKGKR KEEIQRWKHA LTQVAQIEGL MIIPLSRETE AEMIDDIATD VSNKLNNSAP SSDFDGLVGI ESHMTKMGPL LQLDSDEVRK IGILGPPGIG KTTIARCLFN QHSRDFQLSV FMDNIKRKYV RLACSDDYNV KLDLQKQFMS QLTNEPCIRI PHLGVAKDRL KDKKVLVVLD DVDHLVQLEA MANETSWFGP GSRIIITTQD QKVLNASGID HIYRVDLPSY DEALQIFCMY AFGHNYPKDG FETLACQVRN LVGRLPLGLR VMGSYFRGMS EQNWTEALPR LRSHLDRDGE IANILKFSYD ALCSEDKSLF LHVACLFDYD EVDTVEACLA SCFLNVKQGL RVLAEKSLIS IESRWIKMSE LLVQLGRKIV REQYVSEPWK RQFLNEAIDI GEVLSDDKAP LSNLKWMDLT NSSNLKELPN LSTATNLQEL DLSYCSRLEE LPDLSTATNL QKLELRHCSS LVELPYSIGN AVNLRELDLN NCSSLVKLPS SIGNAVNLKE MNLSHCSNLV EIPSSIGNAV NLREFDLNNC SSLVKLPSSI GNAVNLKEMN LSHCSSLVEL PSSMRNLGRL SELKLKECSK LEVVLTNINL ESLKELNLSG CSLLKIYHES STDIQELDPW LWRKSCLQFL ALRGMKKLVS LLPLPDSLLE LDAEDCESLE RLDCLFPNPN IRLNFLNCFK LNQEARDLII RTPTNQYAVF PAGEVPMCFT YRSYGSSVTV NLNQNPLGTS TKFKACFICA VEDEEDFQNS ESVFCSITSG GIALTAFFKI LHRFSPGHLY TFDVEVETEE VTSTELVFEF DLGYSDTNVK IKECGIFQLL EVPLLSFRDG DED // ID M4DMS2_BRARP Unreviewed; 926 AA. AC M4DMS2; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra017807.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra017807.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra017807.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra017807.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra017807.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra017807.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 3711.Bra017807.1-P; -. DR PRIDE; M4DMS2; -. DR EnsemblPlants; Bra017807.1; Bra017807.1-P; Bra017807. DR Gramene; Bra017807.1; Bra017807.1-P; Bra017807. DR InParanoid; M4DMS2; -. DR OMA; RYLEWHE; -. DR Proteomes; UP000011750; Chromosome A03. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 12 32 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 61 199 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 926 AA; 104112 MW; 57DBF2F08E904D0B CRC64; MLMDSSFPLI NVVAAAINLF TLLGTIFFLF FYRKSRSHQE NKTVASSLSL LSPPSSLPQK WKHHVFPSFH GADVRKAFLS HVLKEFRRKG IDPFIDNDME RSKSIGSELI EAIRGSRIAL VLLSKNYASS TWCLNELVEI IKCREELDHT VMVLFYEVDP ADVKTQTGDF GKVFRKTCKG KTKEEIGRWK HALAEVAKIT GYHSRNWDKE ADMIEKIATD VSNKLNNSTP SSDFEGLVGM DSHVTKMELL LRLDSDEVRI IGILGPPGIG KTTIARFLFN QHSGNFQLSV FMKNIKTKYA IPACSDDYAV KLYLHEQFMS QLFNEKSFTV SHLGTARDRL KDKKVLVVLD DVDKLVQLEA MARETCWFGP RSRIIITTQD QKLLKASGIN HVYKVDFPSN DEALQMFCMY AFGQKNPKDG FVKLACEVTR LVGELPLGLR VMGSYFRGMS KQEWKRALPR LMTRLDGEIE SILMISYDAL SDEDKSLFLH IACFFDCELV DIVEGCLANS FLDVTQGLHV LAEKSLLSMD SGVIEMHKLL VQLGREIVRK QSVSKPGKRQ FLYHAKDIGE VLSDDKAENF DNGATSNVIG IDLPFCDGSE EDIACTSERA FERLSSLQFL RICGDGINPR SLNSISQKLR LLSWIEFRMS CFPSSFNPKF LVQLDMRYSK LEKLWEKTQP LSNLKWMDLR FSANLKELPD LSTATNLCDL DLRYCSSLVR LPSSIGNTVN LQKLNLGHCL SLVELPYTIG KATNLKYLDI RHCSNLVELP STIGNITNLE ELNLSYCSSL VELPSSMGNL HKLSKLDLNK CSNLEVVPAN INVASLIEPN LSDCSLLKSA MKLNQNPLGG ISTKFKAGII FAENKYAFDG VGESGNVYCI ITSKQNAPYV CLSGRSRVRR DSSAMVVFWD YIFVQSCLTN GANILS // ID M4DSB6_BRARP Unreviewed; 1338 AA. AC M4DSB6; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra019409.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra019409.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra019409.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra019409.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra019409.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra019409.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 3711.Bra019409.1-P; -. DR EnsemblPlants; Bra019409.1; Bra019409.1-P; Bra019409. DR Gramene; Bra019409.1; Bra019409.1-P; Bra019409. DR InParanoid; M4DSB6; -. DR OMA; AFEFRSH; -. DR OrthoDB; EOG09360FZ0; -. DR Proteomes; UP000011750; Chromosome A03. DR ExpressionAtlas; M4DSB6; baseline. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 75 206 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1338 AA; 151006 MW; 49D5E489BFB47174 CRC64; MDLSIFLNIV AAAIGFFFIL RKLRSHQENK EFDLSSLTIL SVNPRSFYSS SLSPSSPPSS LSISSVPRSS SSQVWIHDVF LSFRGEDVRN NFLSHIQKEF KRKGITYFND NGIKRGESIA PELIRGIRGS KIVIVLLSRN YGSSKWCLEE LVEIMKCREE LKQTVMAIFC KVDPSDVKKL TGDFGKVFRK TCEGQTKEDI WRWKQVWRRD DEASMVEEIA TDVSNDLINF VISSDFEGFA GMEAHMKKME PFLLLGSNEV RIIGIWGPSG IGKSTIARVL FSQHSHEFQL SVFMENIKRR SPRPCSDEYS AKLKLQEEFL SKIINQEDVK IHHLGVAPDR LKDKRVLVVL DDVDHLMQLD AMAKDHSWFG PGSRIIVTTQ DKKILTAHGI NHIYKVEYPG FSEAFEIFCM YAFGQKSPYD GFEKLAWEVK EFAGDLPLGL KVMGSYFKGM LKHEWEEELP RLSARLDGEI ESSLKLRYDA LSVDTQDLFL HLACFFNNER IEKVEEYLAR NIVGVKGQLR VLAEKSFISV VGGCIKIHDL LARLGREIVR KQCIHEPGQR QFLVDVGDIC QVLQNDTLGS RSVIGIDLKL LELETELKIS DRAFERMSNV QFLRLLHSDS DLESGSGSDS GRPKQTCHHI IDLMTCLPPN LKLLHWDFFP MTCLPSNFIS EFLVEIALRK SNYLEKLWKG NKTIRNLKWM YLSDSKNLKE LPDLSTATSL QELNLHGCSN LAELPISIGN VISLRRLNLS HCSSLVGFPS SIWNLVDLGK LDFSHCSSLV RLPSSSGNAI IKLKVLDLSG CTSLMELPSS MENATDLEEL NLTGCLHLAK LPSSIGNLKK LYLKDCSSLV ELPSSVRNSI NLKDFTFNGC SNLVELPFYL GNATDLKKID LSGCSSLREL PSSIGNMTNL MHLYLDECSS LLELPSSIGS MTSLLYLYLN ECSSLVELPS SIGNINNLMK LHLNGCSSLV ELPSSIGNMN NLGNLDLNGC ASLVELPSSI GNINHLRKLS LNGCSSLVEV PSSIGHMKHL RKLYLERCSK LTALPININM KSLGKLILTD SSSLKCVPEI STNISVLKLT GTSIEELPRS IMSWPRLREL HLSDTRIQEI APWVKERSSL RELVIKGCTK LVSLLQLPDS LKFLVADNCG SLERLDCSFY KTKFHGISFV NCFGLNQEAR EIIINTWTRD FAIFPGETMP TYFIYRATRS SLSMTWNGLD TQYFPTSLRF KACLLLVYKG DVDAGDWCWP DISYCIKDKL NGVKSGYVAY AYSWHRSSPT SKEHLLVFKI EEKVGSPELA FEFRSHDKNW EIEECGLRPL ESWKQLLWNP WLPHVHGS // ID M4DZX4_BRARP Unreviewed; 772 AA. AC M4DZX4; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra022071.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra022071.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra022071.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra022071.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra022071.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra022071.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR ProteinModelPortal; M4DZX4; -. DR EnsemblPlants; Bra022071.1; Bra022071.1-P; Bra022071. DR Gramene; Bra022071.1; Bra022071.1-P; Bra022071. DR InParanoid; M4DZX4; -. DR OMA; IANMSEL; -. DR OrthoDB; EOG09360CZB; -. DR Proteomes; UP000011750; Chromosome A02. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 15 153 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 772 AA; 88338 MW; 57CB5655BB791496 CRC64; MALSLSSSSS SSRTCTYDVF PSFSGEDVRI TFLSHFLKEL DKRLIIAFKD NETQRSLSLG PELKQAIRDS RIAVVIFSNK YASSSWCLNE LLEIVKCREE CGQMVIPVFY RLDPSHVRKQ TGDFGNIFEE TCKNKTEEVI IQWRRALTDV ANTLGYHSVN WDSEAKMIEE IVSDVSDKLL LTPSEDSENF VGIEDHIAEM SVLLQLESEE VRMVGIWGCS GIGKTTIARV LFNRLSRHFQ GRIFIDRAFL SKSMDIYSQA NPYDYNLKLH LQSEFLSKIL GKKDIEISQL GELAGRLKHH KVLVFIDDLN DQVVLDSLVG QTQWFGSGSR IIVVTNDKHF LRAHGIEHIY EVCLPSEDVA REILCRSAFR EKSPPEGFEE LVYEITRLVG SPLGLTVLGS SLRGRDNEYW MDSLSMLQTG KNGKIEKISR ISYDGLSSEE DKTIFRYIAC YFNGGKVAYM KLLLADSGLS VNVGLENLAD KSLIHVREGR VEMHGLLKKM GKKVVRLEKP ENREFLEDSQ DIFDVLTKGI GTEKVLSISL NISTIEELHV HENAFKRMRN LRFLKVLGSD ESGTMKLRIP KSFDYSKLKL LRWRDYPMRC LPSKFRPENL VELKMQNSKL EKLWEGVVAL PYLKEMDLRY SHDLMQMPDL SKATNLEILN LSQCYSLVKL PSSIPHPNKL RKLNMRDCRN VETIPIGISL KSLEKLDLDG CSRLRTLPQI STNIVHLCLS ETAIEEFPSD LHLENLRFEK LSYLSMQNLK SKKLWEKVQV CM // ID M4F5Q7_BRARP Unreviewed; 1048 AA. AC M4F5Q7; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra036413.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra036413.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra036413.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra036413.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra036413.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra036413.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 3711.Bra036413.1-P; -. DR EnsemblPlants; Bra036413.1; Bra036413.1-P; Bra036413. DR Gramene; Bra036413.1; Bra036413.1-P; Bra036413. DR InParanoid; M4F5Q7; -. DR OMA; DELFFEF; -. DR Proteomes; UP000011750; Chromosome A07. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 50 188 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1048 AA; 119431 MW; 5F256AC69368BBD6 CRC64; MDLYLLLVTV SATIFTLLGR RIFSFVYGKF KVQENRIIAS SPKSTLPRNC THDVFPSFHG ADVRKSFLSH LVKEFGSKGI NLFIDNEITR GEFIGPELKK TIQGSRIAIV LLSKRYASSS WCLDELVEIM KCKEELGQTV VPVFYEVDPS DVKKQAGEFG KVFKKTCKGK TNEVIRKWSK ALAKVATLAG YHSKNWDNEA KMIEDVATDV AKKLFNSTPS RDFDEFTGME AHMEKISLVL RTDLDEVRMI GIWGPAGIGK TTIARCLFNQ LSHTFQHSVF MMNVKAMYTP PVCSDDYNVK LHLQQKFLSQ LLNQSEDLKI SHLGVAQERL NDKKVLVVLD NVDRLVQLEA MAKEILWFDV LYVCFWPKVP PEDGFEKLVW EVTRLAGNLP LGLRVMGSYF RGMSKQEWEN ELPELRMCLD GEIESILIFG YNALSHVNKD LFLHIACFFM FERIEKVVEH LSKRFSDVRQ RLNVLAEKSL IYFESEYVIM HDLLVQLGRD IVRKQSTEPG QRQFLVDERE TGEVLADDAA GSRSVIGIMF RGDEINVGER AFEGMSNLQF LRFRSEPDVA PSYLSRKLRL LDWSYFPMTC LHCIPNPELL VELIMRESKL ENLWEGTKPL SNLKWVNLSE STNLKDVCSL STATSLQELD LRGCSSLVEL PSSIGNAIHL KKLDLARCSS LVELPYSIGN AIRNLEELDL SDCSSLVGVP SSIGNATNLK RLYFSRCSSL VELPASIGNL HELESLILRE CCKLEVLPVN ITLKSLTRLD LTDCSSMKYF PEISTNIKYM LLAGTTIKEV PSSIRLWPRL NKLHMSYNEN LKEFPHVLDI MTDLVMSNTE IQEIPPWIKR SSRLRRLVLN GCKELLSLPQ LPSSLSVIEA ENCESLERLD CSFLNQQIDL NFANCFKLNK EARDVIIQTS TYQFTFLPGK EMPNYFNYQS NGGSLVMKLN ERPSPSSMIW KACILLVSED EVKAGKGETV HVHHGIKQNS LDVPCSPSYH ILLPPLTEHL YIFEFEADVT SDELFFEFGV NREEWMIKEC GVHYLNTR // ID M4FCQ3_BRARP Unreviewed; 1109 AA. AC M4FCQ3; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblPlants:Bra038872.1-P}; OS Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica OS pekinensis). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; OC Brassica. OX NCBI_TaxID=51351 {ECO:0000313|EnsemblPlants:Bra038872.1-P, ECO:0000313|Proteomes:UP000011750}; RN [1] {ECO:0000313|EnsemblPlants:Bra038872.1-P, ECO:0000313|Proteomes:UP000011750} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra038872.1-P, RC ECO:0000313|Proteomes:UP000011750}; RX PubMed=21873998; DOI=10.1038/ng.919; RG Brassica rapa Genome Sequencing Project Consortium; RA Wang X., Wang H., Wang J., Sun R., Wu J., Liu S., Bai Y., Mun J.H., RA Bancroft I., Cheng F., Huang S., Li X., Hua W., Wang J., Wang X., RA Freeling M., Pires J.C., Paterson A.H., Chalhoub B., Wang B., RA Hayward A., Sharpe A.G., Park B.S., Weisshaar B., Liu B., Li B., RA Liu B., Tong C., Song C., Duran C., Peng C., Geng C., Koh C., Lin C., RA Edwards D., Mu D., Shen D., Soumpourou E., Li F., Fraser F., RA Conant G., Lassalle G., King G.J., Bonnema G., Tang H., Wang H., RA Belcram H., Zhou H., Hirakawa H., Abe H., Guo H., Wang H., Jin H., RA Parkin I.A., Batley J., Kim J.S., Just J., Li J., Xu J., Deng J., RA Kim J.A., Li J., Yu J., Meng J., Wang J., Min J., Poulain J., Wang J., RA Hatakeyama K., Wu K., Wang L., Fang L., Trick M., Links M.G., Zhao M., RA Jin M., Ramchiary N., Drou N., Berkman P.J., Cai Q., Huang Q., Li R., RA Tabata S., Cheng S., Zhang S., Zhang S., Huang S., Sato S., Sun S., RA Kwon S.J., Choi S.R., Lee T.H., Fan W., Zhao X., Tan X., Xu X., RA Wang Y., Qiu Y., Yin Y., Li Y., Du Y., Liao Y., Lim Y., Narusaka Y., RA Wang Y., Wang Z., Li Z., Wang Z., Xiong Z., Zhang Z.; RT "The genome of the mesopolyploid crop species Brassica rapa."; RL Nat. Genet. 43:1035-1039(2011). RN [2] {ECO:0000313|EnsemblPlants:Bra038872.1-P} RP IDENTIFICATION. RC STRAIN=cv. Chiifu-401-42 {ECO:0000313|EnsemblPlants:Bra038872.1-P}; RG EnsemblPlants; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR STRING; 3711.Bra038872.1-P; -. DR EnsemblPlants; Bra038872.1; Bra038872.1-P; Bra038872. DR Gramene; Bra038872.1; Bra038872.1-P; Bra038872. DR InParanoid; M4FCQ3; -. DR OMA; KEMEICH; -. DR Proteomes; UP000011750; Chromosome A01. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011750}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000011750}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 56 194 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1109 AA; 125322 MW; CC0CAB59D8405BD4 CRC64; MDLYLLLVTV ASTMFTLLCS KIFSIVYAKF IVQENKIIAY SSSSPPSPKS SLPRNCIHDV FPSFHGADVR KSFLSHFLKE LGSKGINLFT EKEIPRGEFI GPELKKAIQG SRIAIVLLSK RYASSSWCLD ELVEIMKCKE ELGQTVMPIF YEVDPSDVKK QAGEFWKVFK ETCKGKTNEV IGKWSKALAK VATLAGYHSN NWDNDVKMIE DVATEVANKL FNSTPSRDFE EFIGMEAHME KISPVLRTDW DEVRMIGIWG PAGIGKTTIA RCLFNQLSDT FQYSVFMMNV KAMHTPPVCS DDYNVKLHLQ QKLLSQLINE KEEDFKISHL GVARERLSDK KVLVVLDNVD RLVQLEAMAK ETRWFGHGSR IIITTQDRKI LKAHGITQIY KVDFPSDREA IQMFCMYAFG QKSPEDGFER LVREVTRLAG RLPLGLRVMG SYFRGMLKEE WENALPGLRM CLDGEIESIL MFGYNALSHE NKDLFLHIAC FFNNEWIEKV VEHLSKRFTD VRQRLNVLAE KSVISLESER VSMHDLLVQL GRDIVRKQST EPGQRQFLVD NREICEVLAD DAAGSRSVIG IIFRGDEIYM SERAFEVMSN LQFLRLNVGP DGGGEAFHLF GEPSYLSRKL RLLDWSYFPM TCLHCIPNPE LLVELIMYGS KLEKLWDGTK PLRNLKWVDL SDSKNLKDVS SLSTVTSLQE LDLTGCSSLV ELPSSIGNAI HLMKLHLGEC SSLVELPFSI GNAIHLEKLD LTGCSSLVEL PSSIGNATNL EFLSLRSCSR LVELPSCFGN IRNLEELDLS DCSSLVGVPS SIGNTTNLKH LKFSRCSSLV ELPASIGNLH KLYSLILKEC CKLEVLPVNI TDCSLMKSSP EISTNIKSMY LSGTANKQVP SSIRLWSRLD ELSCIYDVHL SYYENFKEFP HVLDILTGLL MSNTEVQESS PWIKRISRLC QLVVKGCKEL LSLPQLPSSL SELDAEDCEG IETLDFSFFN QKIALNFANC FKLNKEARDV IIQTSTNYIT MLPGKEMPNY FNYQANGGSL VIKLNERPFP SPMICKACIL LVSKDEVEAA KGQRVYVHHR IKQNSLDVPC NRSELVLFRP LTERTSVHL // ID M5X4A2_PRUPE Unreviewed; 621 AA. AC M5X4A2; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EMJ20882.1}; DE Flags: Fragment; GN ORFNames=PRUPE_ppa025498mg {ECO:0000313|EMBL:EMJ20882.1}; OS Prunus persica (Peach) (Amygdalus persica). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; OC Amygdaleae; Prunus. OX NCBI_TaxID=3760 {ECO:0000313|EMBL:EMJ20882.1}; RN [1] {ECO:0000313|EMBL:EMJ20882.1} RP NUCLEOTIDE SEQUENCE. RG The International Peach Genome Initiative; RA Verde I., Abbott A.G., Salamini F., Schmutz J., Sosinski B., RA Morgante M., Rokhsar D.S.; RT "The genome of Prunis persica."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB638974; EMJ20882.1; -; Genomic_DNA. DR RefSeq; XP_007219683.1; XM_007219621.1. DR EnsemblPlants; ONI22186; ONI22186; PRUPE_2G112700. DR Gramene; ONI22186; ONI22186; PRUPE_2G112700. DR OMA; GCDESII; -. DR OrthoDB; EOG09361AEF; -. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS51450; LRR; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 6 146 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:EMJ20882.1}. SQ SEQUENCE 621 AA; 70411 MW; 24BBBC24E477D21C CRC64; SAPPQWNYDV FLSFRGVDTR NSFLSHLYHE LQHRCIKTFM DDPKLERGTT ISSELFKAIQ ESRLAIVVLS PNYASSSWCL DELTNNLQCM KSNDTVLPMF FNVDPSDVRI QSGIFAGAFA EHEKRFREDI EKVKRWRAAL TEVANLSGKV HRTFKLLDST ELVGIKFTRE QMDLLLDPTD DVRFVGIWGM GGIGKTTIAR LVYESIYIHF EVSCFLANVR EASEGNCLVD LQTQLLFPVL KKQITQVLNE DWGTYFIKNC LCNKKVLLIL DDVNASSQLE KFAKEKDWFG KGSIIIITTR DKRLDLPNLK YIGLSFSRNL ATTPIFTGIP KLKVLNLQWC ENLVEIHPSV ADLKWLTHLI LNGCKSVKSL PKEIEMDSLI YLYLQGCSKL KKIPEFSGQM KKISTPDLKG TPVEKLPSSI GRLVGLTFLN VGNCENLLGL PSEICNLKSL EWLFRDIPVD IGCLSSLEEL DLSRNNFVSL PPSIGCLPKL KSLKNEGCDE SIILGMLWIA MDWRFLQVPR WNIPAFQIVT PGSRIPEWFN NQSVGYSLIV ELPSCTTSIW IAFCDVFEEV FLTLTLTEYI TRKPINCFVG IPTLSSSLHL LDSLCNLLQL CSLLLFSISE F // ID M5X8T1_PRUPE Unreviewed; 1075 AA. AC M5X8T1; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 30. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EMJ21886.1}; GN ORFNames=PRUPE_ppa021903mg {ECO:0000313|EMBL:EMJ21886.1}; OS Prunus persica (Peach) (Amygdalus persica). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; OC Amygdaleae; Prunus. OX NCBI_TaxID=3760 {ECO:0000313|EMBL:EMJ21886.1}; RN [1] {ECO:0000313|EMBL:EMJ21886.1} RP NUCLEOTIDE SEQUENCE. RG The International Peach Genome Initiative; RA Verde I., Abbott A.G., Salamini F., Schmutz J., Sosinski B., RA Morgante M., Rokhsar D.S.; RT "The genome of Prunis persica."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB638974; EMJ21886.1; -; Genomic_DNA. DR RefSeq; XP_007220687.1; XM_007220625.1. DR OMA; KELDICC; -. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 21 161 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1075 AA; 123175 MW; 0F047B978407C577 CRC64; MTTQPDSSSP SSSSFTHDSS WKYDVFLSFR GEDTSTNFTD HLYKALCDKG IYTFIDRELV RGEEISPALV KAIEESRISL IVFSENYASS RWCLDELVKI LQCKESKQQI VFPIFYKVDP LDVRHQISSY GDAFVHHERK FKDDKKKMLK WRRALKEAAN LSGWHFEKGA CWWEWSRMVG IWGTSGIGKT TIAKAIWNAI AHEFEGSCFL PNVREGSLVQ LHETLLDKVL GKNWKIQSVD EGIGVIKKRL RHKKILLILD DVDHLEQLEN LAGDDWFGEG SRVIITTKDR GLLDNREIEL IYEVKKLEYN LALELFSWHA FGRSEPPKDY LELAQRAIAF ADGLPLALTI LGSHLRNRSI GRGQVILDGY KGEPYTHIER ILQKSYDALD DDAKEVFLDI ACFFKGGNKN SVLGIVPKNC IEVLVDKAMI TIEFNHRILM HDLLEKLGKD IVHKESPNDP GKRSRLWFYE DVKQVLTEST GTRNIKGIMV KLLEPDEIIL NPECFRNMVN LQIFINHNAS LRGAINYLPN TLRFIDWPSC QLQSLPPNFQ GNRLVAFNML SSHIRHLEGF KHLPNLTSMD LSGCQFLEKI PDLSGIPNIK YLILSGCRRL VEIDDSVGLL DKLVQLNLSR CVKLTRFATT LRLKSLEELD LSDCKRLKSF PEIEVEMESL WTLNMAGSGI RELPLSIAYL TGLLDLILKR CFNLTGLELR LLYFWSTLRY LDLSGNNFVT LPECISKFVS LDQLDLRDCK SLLEIPQEVL PPRVYVVLLD NCTSLEKIPK LPLSSEVEYL RLINCVRLRG YDITENSILD QVSSRSHSEF TITLPGDEVP KWFSCCKDAT LLKEEFVIAR CEVCFEIPPN LDWKTLRLVL CVINKGKSYV RIDRGEVESR VHINGKMVQS THMFVFRSKN KKTKIEESHM ALKCIPLLNL SELGVEEELT RLQQGNMCQI IFEFYRMPTP VKILCGVHLL GHQVADVTVD RGQRQWLLPD AMAVDDDIHD DQHQDNELLS LPSASETSLG KRPRLSDFMA LDDDHRANVV DVGDHEAQRG EVDHPKRRHI DLNEEPKYVN PLNIE // ID M5XM17_PRUPE Unreviewed; 1131 AA. AC M5XM17; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 28-MAR-2018, entry version 35. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EMJ20100.1}; GN ORFNames=PRUPE_ppa000489mg {ECO:0000313|EMBL:EMJ20100.1}; OS Prunus persica (Peach) (Amygdalus persica). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; OC Amygdaleae; Prunus. OX NCBI_TaxID=3760 {ECO:0000313|EMBL:EMJ20100.1}; RN [1] {ECO:0000313|EMBL:EMJ20100.1} RP NUCLEOTIDE SEQUENCE. RG The International Peach Genome Initiative; RA Verde I., Abbott A.G., Salamini F., Schmutz J., Sosinski B., RA Morgante M., Rokhsar D.S.; RT "The genome of Prunis persica."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB638974; EMJ20100.1; -; Genomic_DNA. DR RefSeq; XP_007218901.1; XM_007218839.1. DR ProteinModelPortal; M5XM17; -. DR OMA; MELERNM; -. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 12 153 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1131 AA; 128259 MW; 1DDF35C25E0CC55B CRC64; MTTQPVSSSS SFSYDVFLSF RGGDTRFNFT DHLHKALVRK GIWTFIDREL VRGEEISPAL VKAIEESRIS LIVFSEKYAS SRWCLDELVK ILQCKQSKQQ VVLPIFYKVD PSHVRNQKSK FGDAFEELIK RKFKNDKEKV LIWREALTEA ANLSGHTFKD GEYETTFINN IVDGILSQVL SRTYWNVAKH PVGIHSRVQD VKKLLDVGGN GRRMVGIWGT SGIGKTTIAK AIWNAIAHKF EGSCFLSNVR ENSMSDGDLI KLQEILLHKI LGGEWKIHSV DEGIGVIKER LSHKKILLIL DDVNQLKQLD NLAGVGWFGE GSRVITTTQD SGLLKCHGID LIYEVQKLYR NQALELFSFC AFGTNKPPKD YLELAQRALE YAQGVPLALT ILGSHLRNKD KDRWQDILNS YEGEPYTGIQ KILQKSYDAL ENSMQQFFLD IACFFKGKKK DYVLQIVSNS KNKVSRDCIE VLIQKAMITI DYGTIQMHDL LEKLGKDIVH KESPNDPGKR SRLWFYEDVE QVLTESTGTR NIKGIIVKLP EPAEITLNPE CFCNMVNLEI FINRNASLCG HINYLPNALR LIDWDRCQLQ SLPPNFQGNR LVEFNMPRSH IRQLDGFNFK HLSKLTSMNL RGCQFLEKIP DLSGIPNIKY LNLRECTLLF EVDGSVGFLD KLVELDLGGC FNLTRFGTRL RLKSLKKLYL NNCKRLESFP EIEVEMESLQ ILDMQESGIR ELPPSIAYLT GLQKLNLGGC FNLTRFATLG LKSLELLDLC GCKRLESFPE IEVEMESLRI LYISGSGVRE LPSSIAYLTG LSHLFAAYCE NLTITFNSQV SSSNSELQLL PNLFQFSLTG CNLSKIDLLL HLDCWSTLTE LDLSGNNFVN LPRCFSKFVN LRTLDLSYCK SLLEIPEQVL PPGIESVSLY NCTSLEKIPK LAWVLLDNCT SLEKIPELPR KDDNMYLSLI NCVRLRGYDI TENIFLNQVS VSSSRSHFDI RLPGDEVPKW FSCRKGPGTK KYNSGCEVIF EIPPNLKWET LRLVLCVVTQ ADVKILLNGK LVNEKHIASW ESHVQLTSIP LLDKYAYEFE EPLTKQGNTC QVIFDLFVKV PTPVKIPCGV HLLGHQVADV SETAVVDHGP T // ID M7B4S9_CHEMY Unreviewed; 487 AA. AC M7B4S9; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 25-OCT-2017, entry version 21. DE SubName: Full=Interleukin-1 receptor type 1 {ECO:0000313|EMBL:EMP27148.1}; GN ORFNames=UY3_15747 {ECO:0000313|EMBL:EMP27148.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP27148.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., RA Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., RA Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., RA Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J., RA Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G., RA Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield RT insights into the development and evolution of the turtle-specific RT body plan."; RL Nat. Genet. 45:701-706(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB573110; EMP27148.1; -; Genomic_DNA. DR ProteinModelPortal; M7B4S9; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000031443}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EMP27148.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 261 283 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 17 92 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 124 191 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 307 465 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 487 AA; 56373 MW; 9D3CC830D2638F85 CRC64; MVHDVLHSQS LVSVLVGEPL TIDCLLDKTL ALQHMNYSLT WYKSGRKMPV TQVKLSRIHQ HGNLLSFMPA ILEDSGSYEC VIWNLTSCKK IYFNVIVFKN TAGLCFNGDF FYAQEITASS NEKIVCPHLD YFRDEKNTLP IHWYKECNLI DNERFLNWNE DLIIISVNVN DSGNYICKRT YNYMGKEYNI SRNIYVTVIE TPLKKKTEIL YPRNNTIEVE LVTLSITEVK QEDYGRQFVC HAGEVAAYIA LRQSVRNFQG YLTGGLLAPV FVIVVAILIY KYFKVDIVLW YRKFCRPFLS KEVSDGKIYD AYVLYPKINK VDCIYPPDNF VLMLLPEVLE RQCGYNLFIL GRDDLPGKAV VSVVDETIKQ SRRLIIVLVP ESSSCSLLED IFEQQLVVYN ALVQDGIKVI LIELDKIKNY TNMPESIKYI KQKHGAIRWK GDFTEKSYSA NTKFWKNVRY QMPSRCPTSS ELHLLPTTLN TFQTTER // ID M9NK50_ANAPL Unreviewed; 857 AA. AC M9NK50; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Toll-like receptor 5 {ECO:0000313|EMBL:AFJ04295.1, ECO:0000313|Ensembl:ENSAPLP00000000694}; DE Flags: Fragment; GN Name=TLR5 {ECO:0000313|Ensembl:ENSAPLP00000000694}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|EMBL:AFJ04295.1}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000000694} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AFJ04295.1} RP NUCLEOTIDE SEQUENCE. RA Elfeil W.M.; RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSAPLP00000000694} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [4] {ECO:0000313|Ensembl:ENSAPLP00000000694} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADON01045456; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JN573267; AFJ04295.1; -; mRNA. DR Ensembl; ENSAPLT00000001265; ENSAPLP00000000694; ENSAPLG00000001279. DR GeneTree; ENSGT00760000119006; -. DR OMA; KYDAYLC; -. DR OrthoDB; EOG091G030N; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027176; TLR5. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44698:SF2; PTHR44698:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:AFJ04295.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 639 659 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 690 826 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 857 857 {ECO:0000313|EMBL:AFJ04295.1}. SQ SEQUENCE 857 AA; 98551 MW; 7C8796952DD61FBE CRC64; MLHQQLVLVF GISLARDIFA PRCYSEAQVA MYNSCNLTAI PPVPKNTMKF LLNFNYIREV NAFSFPLLEH LLHLEIGSQY VSPVIIGKEA FRNLPNLRVL DLGQNEILQL DLDAFVGLTS LTELRLFHNN LGASILEEHY FQDLISLEKL DLSGNQITKL QPHSLFYNLT VLKSVNLAFN DISKLCESNL TSFQGKHFSF FSLRDTYLYK INETVWAKCP NPFRNITFNL LDVSHSGWSA EKVQHFCTAI KGTPINNLSF SFHTMGSGFG YNNLKNPDND TFTGLAKSDL RVLDISNGYI FSLNSLIFKS LGNLESLNLF RNKVNQIQRQ AFFGLGKLTT LNLSSNLLGE LYDYTFEGLH SVMYIDLQQN HIGMIGQKSF SKLVNLKIIN LRDNAIKKLP SLPRLTYAFL GENKLMSVSD TAIAATYLEL ERNWLADLGD LYVIFQVPGV QYIFLKQNHF SYCEKSVTVT ENNQLIFMDL GENMLQLVWE RGSCLDVFRP LSKLQVLFLN NNYLNALPQG IFSGLISLEG LNLASNLLSH LSPGIFPKSL RHLNLSGNQL FSPEPEVFMS LRTLDITHNS YVCDCTLKSL LVWLNETNVT LAGSQFDRYC VYPPMLAGEP LSFLTHDCDE DELQQALRFS VFIFTSTTLL MFLMAVIIFT RCRGICFVWY KTITKQLIDR HPPAAGTSEY KYDAYLCYSK NDFEWVQNSL LKRLDSQYFD KNRFTLCFEE RDFMPGEEHI NNIRDAIWNS RKTICIVTRQ FLKDGWCVEA FNFAQSRYFS DLKDVLVMVV VGSLSQYQLM KHKPIRIYLQ RSQYLRWPED YQDIEWFLNN LSYQILKEKK VQRNVDGIEL QTVATLS // ID Q28YE4_DROPS Unreviewed; 1445 AA. AC Q28YE4; DT 04-APR-2006, integrated into UniProtKB/TrEMBL. DT 14-OCT-2008, sequence version 2. DT 28-MAR-2018, entry version 90. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAL26021.2}; GN Name=Dpse\GA21191 {ECO:0000313|EMBL:EAL26021.2}; GN ORFNames=Dpse_GA21191 {ECO:0000313|EMBL:EAL26021.2}, GN GA21191 {ECO:0000313|FlyBase:FBgn0081179}; OS Drosophila pseudoobscura pseudoobscura (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=46245 {ECO:0000313|EMBL:EAL26021.2, ECO:0000313|Proteomes:UP000001819}; RN [1] {ECO:0000313|EMBL:EAL26021.2, ECO:0000313|Proteomes:UP000001819} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MV2-25 / Tucson 14011-0121.94 RC {ECO:0000313|Proteomes:UP000001819}; RX PubMed=15632085; DOI=10.1101/gr.3059305; RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., RA Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., RA van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E., RA Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., RA Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., RA Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., RA Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., RA Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A., RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W., RA Weinstock G.M., Gibbs R.A.; RT "Comparative genome sequencing of Drosophila pseudoobscura: RT chromosomal, gene, and cis-element evolution."; RL Genome Res. 15:1-18(2005). RN [2] {ECO:0000313|EMBL:EAL26021.2, ECO:0000313|Proteomes:UP000001819} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MV2-25 / Tucson 14011-0121.94 RC {ECO:0000313|Proteomes:UP000001819}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 Genomes Consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., RA Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., RA Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., RA Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W., RA Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., RA Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., RA Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., RA Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., RA Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., RA Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., RA Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., RA Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., RA Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., RA Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., RA Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., RA Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., RA Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., RA Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., RA Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., RA Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., RA Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., RA Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., RA Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., RA McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., RA Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., RA Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., RA Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., RA Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., RA Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., RA Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., RA Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., RA Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., RA Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., RA Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., RA Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., RA Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., RA Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., RA Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., RA Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., RA Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., RA Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., RA Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., RA An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., RA Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., RA Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., RA Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., RA Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., RA DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., RA Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., RA Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., RA LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., RA Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., RA Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., RA Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., RA Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., RA Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., RA Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., RA Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., RA Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., RA Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM000071; EAL26021.2; -; Genomic_DNA. DR RefSeq; XP_001361443.2; XM_001361406.3. DR ProteinModelPortal; Q28YE4; -. DR STRING; 7237.FBpp0278316; -. DR EnsemblMetazoa; FBtr0279878; FBpp0278316; FBgn0081179. DR GeneID; 4804967; -. DR KEGG; dpo:Dpse_GA21191; -. DR FlyBase; FBgn0081179; Dpse\GA21191. DR InParanoid; Q28YE4; -. DR OMA; NHAFIGR; -. DR Proteomes; UP000001819; Chromosome 3. DR Bgee; FBgn0081179; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa. DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa. DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa. DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 19. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001819}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000001819}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 1445 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004204497. FT TRANSMEM 1052 1075 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1101 1241 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1445 AA; 160955 MW; 92FA2E6151614F68 CRC64; MEFPLLLPLV SVLLLGSASD WSCLAALAPK ESGDNSASAM LGGGAGSASV SLSGDYSSLL SAAMPPASAD DSSPAAPAHS GPSNQCSWTY NGTSSVHCAL RLIERQPGLD LQGADGSSQL TIQCSDLYLF ESTLPVAVFA RLQTLETLRL EACKLLQLPN NAFEGLGTLK TLRLSSHNAE WGPARALELY PDSLNGLKQL TELDMSDNNL RALPAGFLCP VGNLQALNLT HNRIRTAEQL GFADMNCSGG SELQLLDASH NELRSITESW GISRLRRLQH LNLQHNNISE LSGEALAGLA SLRIVNLSNN HLETLPEGLF AGSKELREIH LQHNELYELP KGLFHRLEQL LVVDLSGNQL TSNHVDNTTF AGLIRLIVLN LAHNALTRID YRTFKELYFL QILNLRNNSI GHIEDNAFLP LYNLHTLNLA ENRLHTLDDK LFNGLYVLSK LTLNNNLISV VEQAVFKNCS DLKELDLSSN QLNEVPRALQ DLAMLRTLDL GENQIRTFDN QSFKNLHQLT GLRLIDNQIG NITVGMFQDL PRLSVLNLAK NRIQSIERGS FDKNFELEAI RLDRNFLSDI NGVFATLVSL LWLNLSENHL VWFDYAFIPS NLKWLDIHGN YIEALGNYYK LQEEIRVKTL DASHNRITEI GPMSIPNTIE LLFINNNLIG NVQPNAFVDK ANLARVDLYA NQLSKLQLQQ LRVAPVVAPK ALPEFYLGGN PFECDCTMDW LQRINNLTTR QHPRVMDMPN IECVMPHARG AAVRPLSALK PQDFLCRYES HCFALCHCCD FDACDCEMTC PHNCTCYHDQ IWSTNVVDCG GQQTMELPRR VPMDSSIVYL DGNNFPVLKN HAFIGRKNLK ALYVNGSQVA AIQNRTFASL TSLQILQLAD NRLQTLHGYE FEQLSSLREL YLQNNLLATI ENATLSPLVS LQLLRIDGNR LVTLPIWQLH ATHFGRRLRS IALGRNQWSC RCQFLQALTS YVAENALIVQ DAQDIYCMAA PNTAGYDASS YDSSSSEGSL QKRELDFNST GAACTDYYSG GSMLQHGIPE SYIPLLAAAL ALVFLLVVII IVFIFRESLR IWLFAHYGVR VFGPRCEESE KLYDAVLLHS AKDSEFVCQH LASELETGRP PLRVCLQHRD LAHDATHYQL LEATRVSRRV VILLTRNFLQ TEWSRCELRR SVHDALRGRP QKLVIIEEPE VAFEAESDIE LLPYLKTSAV HRIRRSDRHF WEKLRYALPA DYPTYRGNNY TLDHNHERVK QPASPGLLYR QAPPPAYCGP AEGGAPSATT APAEQNYSTA TTATPSPRPQ RRGDHHGGVS GSGAAAAPHG HHLHAQYYQH HGMRPPSEHI YSSIDSDYST LDNEQHMLMM PAGPVVSLEG TPRAQTWRPK QQQQQQPGLQ SGPSSVGHVA TMGPSGKTPP QQQQQQQQAV GSGQQQGPHV QAYLV // ID Q2LDA0_BOVIN Unreviewed; 858 AA. AC Q2LDA0; DT 21-FEB-2006, integrated into UniProtKB/TrEMBL. DT 21-FEB-2006, sequence version 1. DT 28-MAR-2018, entry version 113. DE SubName: Full=Toll-like receptor 5 {ECO:0000313|EMBL:ABC68311.1, ECO:0000313|Ensembl:ENSBTAP00000000604}; GN Name=TLR5 {ECO:0000313|EMBL:ABC68311.1, GN ECO:0000313|Ensembl:ENSBTAP00000000604}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:ABC68311.1}; RN [1] {ECO:0000313|EMBL:ABC68311.1} RP NUCLEOTIDE SEQUENCE. RA Reinhardt K.A., Inglis N.F., Eggen A., Piumi F., Smith D.G.E.; RT "Complete Sequence of the Bovine Toll-Like Receptor 5 (TLR5) Open RT Reading Frame."; RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ABU86926.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=44N {ECO:0000313|EMBL:ABU86926.1}, RC 74S {ECO:0000313|EMBL:ABU86927.1}, 80U {ECO:0000313|EMBL:ABU86929.1}, RC and JEW38 {ECO:0000313|EMBL:ABU86928.1}; RX PubMed=17719743; DOI=10.1016/j.ygeno.2007.07.001; RA Seabury C.M., Cargill E.J., Womack J.E.; RT "Sequence variability and protein domain architectures for bovine RT Toll-like receptors 1, 5, and 10."; RL Genomics 90:502-515(2007). RN [3] {ECO:0000313|Ensembl:ENSBTAP00000000604, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000604, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [4] {ECO:0000313|EMBL:AFR42387.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BTA123 {ECO:0000313|EMBL:AFR42394.1}, RC BTA134 {ECO:0000313|EMBL:AFR42395.1}, RC BTA153 {ECO:0000313|EMBL:AFR42396.1}, RC BTA39 {ECO:0000313|EMBL:AFR42388.1}, RC BTA4 {ECO:0000313|EMBL:AFR42387.1}, RC BTA45 {ECO:0000313|EMBL:AFR42389.1}, RC BTA5 {ECO:0000313|EMBL:AFR42399.1}, RC BTA73 {ECO:0000313|EMBL:AFR42390.1}, RC BTA74 {ECO:0000313|EMBL:AFR42391.1}, RC BTA83 {ECO:0000313|EMBL:AFR42398.1}, RC BTA84 {ECO:0000313|EMBL:AFR42392.1}, and RC BTA91 {ECO:0000313|EMBL:AFR42393.1}; RA Jones B.C., Yang E., Cai J.J., Womack J.E.; RT "A phylogenetic examination of toll-like receptor 5 (TLR5) in a RT variety of species."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Ensembl:ENSBTAP00000000604} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000604}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; DAAA02042627; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; DQ335128; ABC68311.1; -; Genomic_DNA. DR EMBL; EU006637; ABU86926.1; -; Genomic_DNA. DR EMBL; EU006638; ABU86927.1; -; Genomic_DNA. DR EMBL; EU006639; ABU86928.1; -; Genomic_DNA. DR EMBL; EU006640; ABU86929.1; -; Genomic_DNA. DR EMBL; JQ805125; AFR42387.1; -; Genomic_DNA. DR EMBL; JQ805126; AFR42388.1; -; Genomic_DNA. DR EMBL; JQ805127; AFR42389.1; -; Genomic_DNA. DR EMBL; JQ805128; AFR42390.1; -; Genomic_DNA. DR EMBL; JQ805129; AFR42391.1; -; Genomic_DNA. DR EMBL; JQ805130; AFR42392.1; -; Genomic_DNA. DR EMBL; JQ805131; AFR42393.1; -; Genomic_DNA. DR EMBL; JQ805132; AFR42394.1; -; Genomic_DNA. DR EMBL; JQ805133; AFR42395.1; -; Genomic_DNA. DR EMBL; JQ805134; AFR42396.1; -; Genomic_DNA. DR EMBL; JQ805136; AFR42398.1; -; Genomic_DNA. DR EMBL; JQ805137; AFR42399.1; -; Genomic_DNA. DR RefSeq; XP_015322242.1; XM_015466756.1. DR RefSeq; XP_015322243.1; XM_015466757.1. DR RefSeq; XP_015322244.1; XM_015466758.1. DR RefSeq; XP_015322245.1; XM_015466759.1. DR RefSeq; XP_015330544.1; XM_015475058.1. DR RefSeq; XP_015330545.1; XM_015475059.1. DR RefSeq; XP_015330546.1; XM_015475060.1. DR RefSeq; XP_015330547.1; XM_015475061.1. DR UniGene; Bt.66307; -. DR UniGene; Bt.90128; -. DR STRING; 9913.ENSBTAP00000000604; -. DR Ensembl; ENSBTAT00000000604; ENSBTAP00000000604; ENSBTAG00000000477. DR GeneID; 444870; -. DR CTD; 7100; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000008675; -. DR HOVERGEN; HBG023182; -. DR OMA; KYDAYLC; -. DR OrthoDB; EOG091G030N; -. DR TreeFam; TF351113; -. DR Proteomes; UP000009136; Chromosome 16. DR Bgee; ENSBTAG00000000477; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027176; TLR5. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44698:SF2; PTHR44698:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:ABC68311.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 858 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014104278. FT TRANSMEM 640 663 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 691 827 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 858 AA; 98002 MW; 2E57A7528FB5F6EE CRC64; MGDCLDLLLG VVLLTSPALG MSSCFFDGWR AIYLSCNLTQ VPQVPNTTKS LLLSFNYIRT VTTASFPFLE QLQLLELGTQ FTPLTIYREA FRNLPNLRIL DLGGSQINFL HPDAFQGLPH LTKLRLFSCG LSDAVLKDGY FRNLASLTHL DLSKNKIQSL YLHPSFRELN SLKSIDFSFN KIPIVCEQEF KPLQGKTLSF LSLADNQLYS RVSVDWNKCL NPFRNMVLET LDVSGNGWGV DIMRNFSNAI NGSQIFSLVL TRHIMGSSFG FSNLKDPDYH TFAGLARSSM IQLDISHGYI FSLNFRIFET LQELKVLNLA YNKINSISRN AFYGLDNLQV LNISYNLLGE LYNYDFDGLP KVAYIDLQKN HIGIIQDKTF KFLGKLNTLD LRDNALKTIY FLPSIPNIFL SGNKLMTLPN IPLTANFIQL SENRLENLND LYFLLQVPHL QILILNQNRF SFCHQNHAPS ENSSLEKLFL GENMLQLAWE TGSCWDIFKG LSHLQLLYLN KNYLNFLPPG VFHHLTALRG LSLKDNRLTV LFPGDLPANL EILDISGNQL LSPDPDLFAS LSAIDITHNN FICECELSAF IHWLNQTNIT IAGSPADMYC MYPNSLAGVS IYSLSTESCE EEEVLESLKF SLFILVTVTL TLFLVITLAV TKFRGFCFIC YKKAQSLLFK DPIKGRESDT YKYDAYLCFS SKDFEWVQNA LLKHLDVQYH SQNRFNLCFE ERDFMPGENH IANIQDAVWS SRKIVCLVSR HFLRDGWCLE AFSYAQSRCL ADLNGALIMV VVGSLSQFHL MRHQSIRGFV QKRQYLRWPE DLQDVDWFLN KLSQCILKKE KERKKDSAIQ LQNVTTIS // ID Q5H719_TAKRU Unreviewed; 1047 AA. AC Q5H719; DT 01-MAR-2005, integrated into UniProtKB/TrEMBL. DT 01-MAR-2005, sequence version 1. DT 28-MAR-2018, entry version 93. DE SubName: Full=TLR7 {ECO:0000313|EMBL:AAW69375.1}; DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSTRUP00000020082}; GN Name=tlr7 {ECO:0000313|Ensembl:ENSTRUP00000020082}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|EMBL:AAW69375.1}; RN [1] {ECO:0000313|EMBL:AAW69375.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15976025; DOI=10.1073/pnas.0502272102; RA Roach J.C., Glusman G., Rowen L., Kaur A., Purcell M.K., Smith K.D., RA Hood L.E., Aderem A.; RT "The evolution of vertebrate Toll-like receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 102:9577-9582(2005). RN [2] {ECO:0000313|Ensembl:ENSTRUP00000020082} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21551351; RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., RA Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.; RT "Integration of the genetic map and genome assembly of fugu RT facilitates insights into distinct features of genome evolution in RT teleosts and mammals."; RL Genome Biol. Evol. 3:424-442(2011). RN [3] {ECO:0000313|Ensembl:ENSTRUP00000020082} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AC156438; AAW69375.1; -; Genomic_DNA. DR RefSeq; XP_011607453.1; XM_011609151.1. DR Ensembl; ENSTRUT00000020164; ENSTRUP00000020082; ENSTRUG00000008051. DR GeneID; 101074686; -. DR KEGG; tru:101074686; -. DR CTD; 51284; -. DR GeneTree; ENSGT00530000063201; -. DR HOGENOM; HOG000230468; -. DR KO; K05404; -. DR Proteomes; UP000005226; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005226}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000005226}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 1047 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014105679. FT TRANSMEM 838 869 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 887 1034 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1047 AA; 120856 MW; F1F26E3621E8CC1B CRC64; MFLLLILGLW CPLCILTANV SYPKTLPCDV TNNGSVVNVD CTERSLKGVP VGIPRDVTNL TLTINHIPNF NSSSFQGLDN LREIDMRCNC VPVKIGPKDR ICTESVTIEE NTFTSLRNLQ SLYLDGNQLY IIPEGLPSSL ILLSLEVNHI YYISKANLSE IRNIESLYLG QNCYYRNPCN FSYGIEEGAF LELHNLKLLS LKSNNLSFIP HHLPSSLKEL YLYNNNFQQV TDEDFKNLTN LEILDISGNC PRCYNVPFPC NPCPNNSPLQ ISKSAFKTLT KLKTLRMHSN SLRYVVPEWF ASTKELRVLD LSSNHLARDI GVTLFPHHLG KLQELDLSFN YELQRYPRTL RLSCSFKSLN SLRILRLQGF VFQQLKPESI TPLKSLTNLE VLDLGTNFIK MTNLSILMEL KSFKIINLSN NRISSPSDGQ AAVGFSGGQA WEWSPMLPAD QYQNEEVREI HYFRYDEYAR SCKYKDKELG VIASFVKREC SQFGKTLDVS RNNIFFLHSR FLNLRELKCL NLSGNAMSQS LNGSEFTYLT GLQYLDFSSN RLDLLYSTAF QELKNLVILD ISNNNHYFES EGLTHMLNFT QNLKNLKILM MNHNKISTST NTELESQSLE RLEFRGNRLD MLWRDGNTRY LNYFKKLSNL AVLDISHNNL NSIQQQVFSG LPDTLSELYV NNNKLKSFAW GELSLLPSLL VLDLSGNYLT TVPHMLSNCS KSLKKLILHK NEILKLTPDF LKYAYNLKYL DLSFNRIGQI EKSNFPDDVV NGMDMLLLHK NRFQCSCSAI WFVMWLNQTT VTIPRLATDV TCASPGAQRG HPVISVDLLA CQHNFLSIIL YFLMTSFTLI FFTLAISSHL FLWDVWYIYH FCRAKLKGYS QLSSQSSVYD AFVMYDKEDS AVSEWVMKEM CVQLEGREDR RLTLCLEERD WIPGTPVIDN LSQSIHRSKR TVFILTNTYI KSGSFKTAFY MAHQRLMDEK NDVIVLIFLE NIPYNSRYLR LRRRLYRRSV LEWPTNPQAR PYFWFSVRSV LATESHKQYN NLFKETL // ID Q9SUK4_ARATH Unreviewed; 1304 AA. AC Q9SUK4; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 28-FEB-2018, entry version 142. DE SubName: Full=Disease resistance RPP5 like protein {ECO:0000313|EMBL:CAB46046.1}; DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:AEE83823.1}; GN Name=dl4490c {ECO:0000313|EMBL:CAB46046.1}; GN OrderedLocusNames=At4g16920 {ECO:0000313|Araport:AT4G16920, GN ECO:0000313|EMBL:AEE83823.1}; GN ORFNames=Dl4490c {ECO:0000313|EMBL:AEE83823.1}, GN FCAALL.311 {ECO:0000313|EMBL:AEE83823.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000313|EMBL:CAB46046.1}; RN [1] {ECO:0000313|EMBL:CAB46046.1} RP NUCLEOTIDE SEQUENCE. RA Bevan M., Stiekema W., Murphy G., Wambutt R., Pohl T., Terryn N., RA Kreis M., Kavanagh T., Entian K.D., Rieger M., James R., RA Puigdomenech P., Hatzopoulos P., Obermaier B., Duesterhoft A., RA Jones J., Palme K., Ansorge W., Delseny M., Bancroft I., Mewes H.W., RA Schueller C., Chalwatzis N.; RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AEE83823.1, ECO:0000313|Proteomes:UP000006548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RX PubMed=10617198; DOI=10.1038/47134; RG EU; RG CSHL and WU Arabidopsis Sequencing Project; RA Mayer K., Schuller C., Wambutt R., Murphy G., Volckaert G., Pohl T., RA Dusterhoft A., Stiekema W., Entian K.D., Terryn N., Harris B., RA Ansorge W., Brandt P., Grivell L., Rieger M., Weichselgartner M., RA de Simone V., Obermaier B., Mache R., Muller M., Kreis M., Delseny M., RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., RA Portatelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., RA Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.A., RA McCullagh B., Bilham L., Robben J., Van der Schueren J., RA Grymonprez B., Chuang Y.J., Vandenbussche F., Braeken M., Weltjens I., RA Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., RA Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., RA van Staveren M., Dirske W., Mooijman P., Klein Lankhorst R., Rose M., RA Hauf J., Kotter P., Berneiser S., Hempel S., Feldpausch M., RA Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., RA Villarroel R., De Clercq R., Van Montagu M., Rogers J., Cronin A., RA Quail M., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., RA Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., RA Benes V., Rechmann S., Borkova D., Blocker H., Scharfe M., Grimm M., RA Lohnert T.H., Dose S., de Haan M., Maarse A., Schafer M., RA Muller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., RA Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., RA Piravandi E., Massenet O., Quigley F., Clabauld G., Mundlein A., RA Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., RA Chefdor F., Cooke R., Berger C., Montfort A., Casacuberta E., RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., RA Frishman D., Haase D., Lemcke K., Mewes H.W., Stocker S., Zaccaria P., RA Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., RA Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sehkon M., RA Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., RA Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., RA Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., RA Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., RA Fulton L., Mardis E., Dante M., Pepin K., Hillier L., Nelson J., RA Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., RA Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., RA O'Shaughnessy A., Rodriguez M., Hoffmann J., Till S., Granat S., RA Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., RA Marra M., Martienssen R., McCombie W.R.; RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis RT thaliana."; RL Nature 402:769-777(1999). RN [3] {ECO:0000313|EMBL:CAB46046.1} RP NUCLEOTIDE SEQUENCE. RA EU Arabidopsis sequencing project; RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:CAB80963.1} RP NUCLEOTIDE SEQUENCE. RA EU Arabidopsis sequencing project; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:AEE83823.1} RP NUCLEOTIDE SEQUENCE. RG TAIR10; RA Swarbreck D., Lamesch P., Wilks C., Huala E.; RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AEE83823.1, ECO:0000313|Proteomes:UP000006548} RP GENOME REANNOTATION. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CP002687; AEE83823.1; -; Genomic_DNA. DR EMBL; Z97342; CAB46046.1; -; Genomic_DNA. DR EMBL; AL161545; CAB80963.1; -; Genomic_DNA. DR PIR; G85188; G85188. DR RefSeq; NP_193425.1; NM_117795.1. DR UniGene; At.33039; -. DR UniGene; At.43451; -. DR SMR; Q9SUK4; -. DR STRING; 3702.AT4G16920.1; -. DR EnsemblPlants; AT4G16920.1; AT4G16920.1; AT4G16920. DR GeneID; 827400; -. DR Gramene; AT4G16920.1; AT4G16920.1; AT4G16920. DR Araport; AT4G16920; -. DR TAIR; locus:2130250; AT4G16920. DR eggNOG; ENOG410IGA8; Eukaryota. DR eggNOG; COG4886; LUCA. DR HOGENOM; HOG000064702; -. DR OMA; GMAIEIC; -. DR OrthoDB; EOG093700JW; -. DR Proteomes; UP000006548; Chromosome 4. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF07725; LRR_3; 3. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006548}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000006548}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 10 145 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1304 AA; 147730 MW; BE661972EF2DD0DA CRC64; MAAASSSGSD IFPSFSGEDV RKNFLSHLLK QLNRRSINTF MDHVIERSCI IADALISAIR EARISIVIFS KNYAASTWCL NELVEIDNCS KYFGQKVIPV FYDVDPSHVR KQIGEFGKVF KKTCEDKPAD QKQRWVKALT DISNIAGEDL RNGPNDAHMV EKIANDVSNK LFHPPKGFGD LVGIEDHIEA IKSILCLESK EAKIMVGIWG QSGIGKSTIG RALFSQLSSQ FPLRAFVTYK STSGSDVSGM KLSWQKELLS EILGQKDIKI DHFGVVEQRL KHKKVLILLD DVDNLEFLKT LVGKAEWFGS GSRIIVITQD RQLLKAHEID LVYEVKLPSQ GLALQMISQY AFGKDSPPDD FKALAFEVAE LAGSLPLGLS VLGSSLKGRD KDEWVKMMPR LRNDSDDKIE ETLRVCYDRL NKKNRELFKC IACFFNGFKV SNVKELLEDD VGLTMLVEKS LIRITPDGDI EMHNLLEKLG REIDRAKSKG NPGKRQFLTN FEDIQEVLAE KTGTEILLGI RLPHPGYLTT RSFLIDEKLF KGMRNLQYLE IGYWSDGDLP QSLVYLPLKL RLLEWVYCPL KSLPSTFRAE YLVKLIMKNS KLEKLWEGTL PLGSLKKMNL WYSKYFKEIP DLSLAINLEE LNLSECESLV TLPSSIQNAI KLRTLYCSGV LLIDLKSLEG MCNLEYLSVD CSRMEGTQGI VYFPSKLRLL LWNNCPLKRL HSNFKVEYLV KLRMENSDLE KLWDGTQPLG RLKQMFLRGS KYLKEIPDLS LAINLEEVDI CKCESLVTFP SSMQNAIKLI YLDISDCKKL ESFPTDLNLE SLEYLNLTGC PNLRNFPAIK MGCSDVDFPE GRNEIVVEDC FWNKNLPAGL DYLDCLMRCM PCEFRPEYLV FLNVRCYKHE KLWEGIQSLG SLEEMDLSES ENLTEIPDLS KATNLKHLYL NNCKSLVTLP STIGNLQKLV RLEMKECTGL EVLPTDVNLS SLETLDLSGC SSLRTFPLIS KSIKWLYLEN TAIEEILDLS KATKLESLIL NNCKSLVTLP STIGNLQNLR RLYMKRCTGL EVLPTDVNLS SLGILDLSGC SSLRTFPLIS TNIVWLYLEN TAIGEVPCCI EDFTRLRVLL MYCCQRLKNI SPNIFRLRSL MFADFTDCRG VIKALSDATV VATMEDHVSC VPLSENIEYT CERFWDALYD DDYKNYFKFC CSNRIKECGV RLLYVYQETE YNQQTTRSEK RMGMTSGTSE EYINLPYGQI VADSGLAALN MELSLGQGEA SSSTSLEGEA LCVDYMITEE QDEEIPILST DSGN // ID R0FU66_9BRAS Unreviewed; 841 AA. AC R0FU66; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EOA26046.1}; GN ORFNames=CARUB_v10019460mg {ECO:0000313|EMBL:EOA26046.1}; OS Capsella rubella. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Capsella. OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA26046.1, ECO:0000313|Proteomes:UP000029121}; RN [1] {ECO:0000313|Proteomes:UP000029121} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23749190; DOI=10.1038/ng.2669; RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L., RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., RA Mandakova T., Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., RA Brandvain Y., Coop G., Andolfatto P., Hu T.T., Blanchette M., RA Clark R.M., Quesneville H., Nordborg M., Gaut B.S., Lysak M.A., RA Jenkins J., Grimwood J., Chapman J., Prochnik S., Shu S., Rokhsar D., RA Schmutz J., Weigel D., Wright S.I.; RT "The Capsella rubella genome and the genomic consequences of rapid RT mating system evolution."; RL Nat. Genet. 45:831-835(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB870809; EOA26046.1; -; Genomic_DNA. DR RefSeq; XP_006293148.1; XM_006293086.1. DR KEGG; crb:CARUB_v10019460mg; -. DR Proteomes; UP000029121; Unassembled WGS sequence. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 3. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00367; LRR_CC; 6. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000029121}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000029121}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 69 207 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 244 264 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 841 AA; 94401 MW; 804C23E43B54C413 CRC64; MNSSFIICSV VAAVGFFKVY KRYRFHQDKK DTTKSSSLSS PSPPSSLSLP SPSTSLSLSS PSTSVSQVWE HHVFPSFHGA DVRKTILSHI LESFRNKGID SFIDNDIERS KSIGPKLVEA IKGSKIAIVL LSKNYASSSW CLDELAEIMK CREVLGKIVM TIFYEVDPTD IKKQIGDFGK AFRKTCKGKT KERTEIWRKA LEDVAQIAGY HSRNWLCSTG KVQAGVENDA TKDNRSFIGI NLDLSETKEE LNISEKALAR MSDLEIIRIN GDKDFDPSQL ERLHSLLYHS QKIRLLDWSY FQNTCLPSTF NLKFLVELDM CFSKLQKLWE GTKQLKNLRR MNLYLSKDLK ELPDLSTATN LEDLFLKGCS SLVELPSSIG NATNLRELDL LGCSSLVELP SSIGNATNLH YLVLSQCSSL VELPSSIGNA TNLQYLVLSQ CSSLVELPSS IGNATSLREL NLSKCSKLVK IPSSIENLTN LEKLNLSDCF NLTELPLSIG TATNLRELNI SGCSSLVNLP SSIGDLTNLK EFDLSNCSRL KSFPEISTNI EVLKLTGTAI KEVPMSIMSC SGLSDFRISY FESLKDFPHA LDIITYLQLN EDIQEVSPWV KEMSCLRTLR LDNCKNLVSL PQFSDSLCEI DADNCQSLER LDCSFEDDYI GLEFRNCFKL NQEARDLIMH TWTATYAILP GTQVPVCFNH RATAEGSLTI KLNESCLPES LSFKACIMLV NINEETVDEH VSMRVNIKIM DKQNDLEVYI NRALTEHIYT FDVEAEDVTS TELVFEFTTT NNSKWKIGEC GFIKLCITYA KLVYDCQCVI SRLCLNEDGE EEEKVKKESK S // ID RPP4_ARATH Reviewed; 1147 AA. AC F4JNA9; O23527; O23528; Q8GW40; Q8L843; Q8S4Q0; DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2011, sequence version 1. DT 28-MAR-2018, entry version 57. DE RecName: Full=Disease resistance protein RPP4 {ECO:0000305}; DE AltName: Full=Protein CHILLING-SENSITIVE 2 {ECO:0000303|PubMed:20699401}; DE AltName: Full=Protein RECOGNITION OF PERONOSPORA PARASITICA 4 {ECO:0000303|PubMed:11846877}; GN Name=RPP4 {ECO:0000303|PubMed:11846877}; GN Synonyms=CHS2 {ECO:0000303|PubMed:20699401}; GN OrderedLocusNames=At4g16860 {ECO:0000312|Araport:AT4G16860}; GN ORFNames=dl4460c {ECO:0000312|EMBL:CAB10461.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INTERACTION WITH RP RSH1. RX PubMed=11846877; DOI=10.1046/j.0960-7412.2001.01229.x; RA van der Biezen E.A., Freddie C.T., Kahn K., Parker J.E., Jones J.D.; RT "Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB- RT LRR genes and confers downy mildew resistance through multiple RT signalling components."; RL Plant J. 29:439-451(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=9461215; DOI=10.1038/35140; RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., RA Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., RA Wedler H., Wedler E., Wambutt R., Weitzenegger T., Pohl T., Terryn N., RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., RA Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., RA Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., RA Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., RA Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., RA Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., RA Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., RA Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., RA Klosterman S., Schueller C., Chalwatzis N.; RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of RT Arabidopsis thaliana."; RL Nature 391:485-488(1998). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617198; DOI=10.1038/47134; RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., RA Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., RA Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., RA Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M., RA Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., RA Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., RA Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., RA Langham S.-A., McCullagh B., Bilham L., Robben J., RA van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., RA Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., RA Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., RA De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., RA van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., RA Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., RA Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., RA Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., RA Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., RA Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., RA Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., RA Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., RA Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., RA Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., RA Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., RA Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., RA Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., RA Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., RA Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., RA Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., RA Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., RA Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., RA Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., RA Chen E., Marra M.A., Martienssen R., McCombie W.R.; RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis RT thaliana."; RL Nature 402:769-777(1999). RN [4] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-157. RC STRAIN=cv. Columbia; RX PubMed=11910074; DOI=10.1126/science.1071006; RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., RA Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., RA Shibata K., Shinagawa A., Shinozaki K.; RT "Functional annotation of a full-length Arabidopsis cDNA collection."; RL Science 296:141-145(2002). RN [7] RP FUNCTION, AND MUTAGENESIS OF SER-389. RX PubMed=20699401; DOI=10.1104/pp.110.157610; RA Huang X., Li J., Bao F., Zhang X., Yang S.; RT "A gain-of-function mutation in the Arabidopsis disease resistance RT gene RPP4 confers sensitivity to low temperature."; RL Plant Physiol. 154:796-809(2010). CC -!- FUNCTION: TIR-NB-LRR receptor-like protein that confers resistance CC to the pathogen Hyaloperonospora arabidopsis isolates Emoy2 and CC Emwa1 (downy mildew disease) (PubMed:11846877). Plays a role in CC the regulation of temperature response during plant growth and CC survival (PubMed:20699401). {ECO:0000269|PubMed:11846877, CC ECO:0000269|PubMed:20699401}. CC -!- SUBUNIT: Interacts with RSH1. {ECO:0000269|PubMed:11846877}. CC -!- SEQUENCE CAUTION: CC Sequence=AAM18462.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=BAC43672.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC Sequence=CAB10461.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=CAB80957.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF440696; AAM18462.1; ALT_SEQ; Genomic_DNA. DR EMBL; Z97342; CAB10461.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL161545; CAB80957.1; ALT_SEQ; Genomic_DNA. DR EMBL; CP002687; AEE83818.1; -; Genomic_DNA. DR EMBL; AY120755; AAM53313.1; -; mRNA. DR EMBL; AK119099; BAC43672.1; ALT_INIT; mRNA. DR PIR; C71436; C71436. DR RefSeq; NP_193420.2; NM_117790.4. DR UniGene; At.43768; -. DR ProteinModelPortal; F4JNA9; -. DR SMR; F4JNA9; -. DR STRING; 3702.AT4G16860.1; -. DR PaxDb; F4JNA9; -. DR PRIDE; F4JNA9; -. DR EnsemblPlants; AT4G16860.1; AT4G16860.1; AT4G16860. DR GeneID; 827395; -. DR Gramene; AT4G16860.1; AT4G16860.1; AT4G16860. DR KEGG; ath:AT4G16860; -. DR Araport; AT4G16860; -. DR TAIR; locus:2129221; AT4G16860. DR eggNOG; ENOG410IGA8; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; F4JNA9; -. DR OMA; TELEDTC; -. DR OrthoDB; EOG093700JW; -. DR PRO; PR:F4JNA9; -. DR Proteomes; UP000006548; Chromosome 4. DR ExpressionAtlas; F4JNA9; baseline and differential. DR Genevisible; F4JNA9; AT. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0030275; F:LRR domain binding; ISS:TAIR. DR GO; GO:0006952; P:defense response; TAS:TAIR. DR GO; GO:0009817; P:defense response to fungus, incompatible interaction; ISS:TAIR. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF07725; LRR_3; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW ATP-binding; Complete proteome; Leucine-rich repeat; KW Nucleotide-binding; Plant defense; Reference proteome; Repeat. FT CHAIN 1 1147 Disease resistance protein RPP4. FT /FTId=PRO_0000433379. FT DOMAIN 11 149 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT DOMAIN 189 446 NB-ARC. {ECO:0000255}. FT REPEAT 548 573 LRR 1. {ECO:0000255}. FT REPEAT 584 606 LRR 2. {ECO:0000255}. FT REPEAT 608 629 LRR 3. {ECO:0000255}. FT REPEAT 630 653 LRR 4. {ECO:0000255}. FT REPEAT 655 676 LRR 5. {ECO:0000255}. FT REPEAT 698 721 LRR 6. {ECO:0000255}. FT REPEAT 722 743 LRR 7. {ECO:0000255}. FT REPEAT 744 766 LRR 8. {ECO:0000255}. FT REPEAT 767 790 LRR 9. {ECO:0000255}. FT REPEAT 792 813 LRR 10. {ECO:0000255}. FT REPEAT 814 836 LRR 11. {ECO:0000255}. FT REPEAT 837 860 LRR 12. {ECO:0000255}. FT REPEAT 926 950 LRR 13. {ECO:0000255}. FT REPEAT 952 973 LRR 14. {ECO:0000255}. FT REPEAT 974 996 LRR 15. {ECO:0000255}. FT REPEAT 997 1017 LRR 16. {ECO:0000255}. FT REPEAT 1018 1042 LRR 17. {ECO:0000255}. FT REPEAT 1044 1064 LRR 18. {ECO:0000255}. FT COMPBIAS 3 10 Poly-Ser. {ECO:0000255}. FT MUTAGEN 389 389 S->F: In the gain-of-function mutants FT chs2-1 and chs2-2; seedling lethality FT when grown at temperatures below 12 FT degrees Celsius. Dwarf plants with FT chlorotic leaves when grown between 16 FT and 18 degrees Celsius. No visible FT phenotype when grown at 22 degrees FT Celsius. {ECO:0000269|PubMed:20699401}. FT CONFLICT 713 713 G -> D (in Ref. 5; AAM53313). FT {ECO:0000305}. SQ SEQUENCE 1147 AA; 130429 MW; F86DBD8A5C9B7DA3 CRC64; MASSSSSPSS RRYDVFPSFS GVDVRKTFLS HLIEALDRRS INTFMDHGIV RSCIIADALI TAIREARISI VIFSENYASS TWCLNELVEI HKCYKKGEQM VIPVFYGVDP SHVRKQIGGF GDVFKKTCED KPEDQKQRWV KALTDISNLA GEDLRNGPTE AFMVKKIAND VSNKLFPLPK GFGDFVGIED HIKAIKSILC LESKEARIMV GIWGQSGIGK STIGRALFSQ LSSQFHHRAF ITYKSTSGSD VSGMKLSWEK ELLSEILGQK DIKIDHFGVV EQRLKHKKVL ILLDDVDNLE FLKTLVGKAE WFGSGSRIIV ITQDKQLLKA HEIDLVYEVE LPSQGLALKM ISQYAFGKDS PPDDFKELAF EVAELVGSLP LGLSVLGSSL KGRDKDEWVK MMPRLRNDSD DKIEETLRVG YDRLNKKNRE LFKCIACFFN GFKVSNVKEL LEDDVGLTML ADKSLIRITP DGDIEMHNLL EKLGREIDRA KSKGNPAKRQ FLTNFEDIQE VVTEKTGTET VLGIRVPPTV LFSTRPLLVI NEESFKGMRN LQYLEIGHWS EIGLWSEIGL WSKIDLPQGL VYLPLKLKLL KWNYCPLKSL PSTFKAEYLV NLIMKYSKLE KLWEGTLPLG SLKKMDLGCS NNLKEIPDLS LAINLEELNL SKCESLVTLP SSIQNAIKLR TLYCSGVLLI DLKSLEGMCN LEYLSVDWSS MEGTQGLIYL PRKLKRLWWD YCPVKRLPSN FKAEYLVELR MENSDLEKLW DGTQPLGSLK EMYLHGSKYL KEIPDLSLAI NLERLYLFGC ESLVTLPSSI QNATKLINLD MRDCKKLESF PTDLNLESLE YLNLTGCPNL RNFPAIKMGC SYFEILQDRN EIEVEDCFWN KNLPAGLDYL DCLMRCMPCE FRPEYLTFLD VSGCKHEKLW EGIQSLGSLK RMDLSESENL TEIPDLSKAT NLKRLYLNGC KSLVTLPSTI GNLHRLVRLE MKECTGLELL PTDVNLSSLI ILDLSGCSSL RTFPLISTRI ECLYLENTAI EEVPCCIEDL TRLSVLLMYC CQRLKNISPN IFRLTSLMVA DFTDCRGVIK ALSDATVVAT MEDHVSCVPL SENIEYTCER FWDELYERNS RSIFSYKDED GDVYWVNWDL MMMLMLI // ID RPP5_ARATH Reviewed; 1449 AA. AC F4JNB7; B9DG46; O23535; Q0WV14; DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2011, sequence version 1. DT 28-MAR-2018, entry version 59. DE RecName: Full=Disease resistance protein RPP5 {ECO:0000305}; DE AltName: Full=Protein RECOGNITION OF PERONOSPORA PARASITICA 5 {ECO:0000303|PubMed:9212464}; GN Name=RPP5 {ECO:0000303|PubMed:9212464}; GN OrderedLocusNames=At4g16950 {ECO:0000312|Araport:AT4G16950}; GN ORFNames=dl4505c {ECO:0000312|EMBL:CAB46048.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=9461215; DOI=10.1038/35140; RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., RA Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., RA Wedler H., Wedler E., Wambutt R., Weitzenegger T., Pohl T., Terryn N., RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., RA Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., RA Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., RA Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., RA Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., RA Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., RA Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., RA Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., RA Klosterman S., Schueller C., Chalwatzis N.; RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of RT Arabidopsis thaliana."; RL Nature 391:485-488(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617198; DOI=10.1038/47134; RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., RA Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., RA Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., RA Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M., RA Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., RA Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., RA Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., RA Langham S.-A., McCullagh B., Bilham L., Robben J., RA van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., RA Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., RA Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., RA De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., RA van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., RA Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., RA Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., RA Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., RA Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., RA Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., RA Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., RA Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., RA Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., RA Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., RA Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., RA Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., RA Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., RA Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., RA Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., RA Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., RA Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., RA Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., RA Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., RA Chen E., Marra M.A., Martienssen R., McCombie W.R.; RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis RT thaliana."; RL Nature 402:769-777(1999). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1374. RC STRAIN=cv. Columbia; RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K., RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., RA Hayashizaki Y., Shinozaki K.; RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 804-1449. RC STRAIN=cv. Columbia; RX PubMed=19423640; DOI=10.1093/dnares/dsp009; RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., RA Seki M., Shinozaki K.; RT "Analysis of multiple occurrences of alternative splicing events in RT Arabidopsis thaliana using novel sequenced full-length cDNAs."; RL DNA Res. 16:155-164(2009). RN [6] RP FUNCTION. RX PubMed=9212464; DOI=10.1105/tpc.9.6.879; RA Parker J.E., Coleman M.J., Szabo V., Frost L.N., Schmidt R., RA van der Biezen E.A., Moores T., Dean C., Daniels M.J., Jones J.D.; RT "The Arabidopsis downy mildew resistance gene RPP5 shares similarity RT to the toll and interleukin-1 receptors with N and L6."; RL Plant Cell 9:879-894(1997). RN [7] RP INTERACTION WITH RSH1. RX PubMed=10725385; DOI=10.1073/pnas.97.7.3747; RA van der Biezen E.A., Sun J., Coleman M.J., Bibb M.J., Jones J.D.; RT "Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant RT signaling."; RL Proc. Natl. Acad. Sci. U.S.A. 97:3747-3752(2000). RN [8] RP FUNCTION, AND INTERACTION WITH RSH1. RX PubMed=11846877; DOI=10.1046/j.0960-7412.2001.01229.x; RA van der Biezen E.A., Freddie C.T., Kahn K., Parker J.E., Jones J.D.; RT "Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB- RT LRR genes and confers downy mildew resistance through multiple RT signalling components."; RL Plant J. 29:439-451(2002). CC -!- FUNCTION: TIR-NB-LRR receptor-like protein that confers resistance CC to the pathogen Hyaloperonospora arabidopsis isolate Noco2 (downy CC mildew disease) (PubMed:9212464). Confers resistance to CC H.arabidopsis isolates Emoy2, Emwa1 and Noco2 (PubMed:11846877). CC -!- SUBUNIT: Interacts with RSH1. {ECO:0000269|PubMed:10725385, CC ECO:0000269|PubMed:11846877}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=1; CC Comment=A number of isoforms are produced. According EST CC sequences. {ECO:0000305}; CC Name=1; CC IsoId=F4JNB7-1; Sequence=Displayed; CC -!- SEQUENCE CAUTION: CC Sequence=CAB46048.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=CAB80966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Z97342; CAB46048.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL161545; CAB80966.1; ALT_SEQ; Genomic_DNA. DR EMBL; CP002687; AEE83826.1; -; Genomic_DNA. DR EMBL; AK226966; BAE99034.1; -; mRNA. DR EMBL; AK317019; BAH19713.1; -; mRNA. DR PIR; B85189; B85189. DR RefSeq; NP_193428.2; NM_117798.4. [F4JNB7-1] DR UniGene; At.33039; -. DR UniGene; At.43768; -. DR UniGene; At.4449; -. DR UniGene; At.67198; -. DR UniGene; At.71837; -. DR ProteinModelPortal; F4JNB7; -. DR SMR; F4JNB7; -. DR STRING; 3702.AT4G16950.1; -. DR iPTMnet; F4JNB7; -. DR PaxDb; F4JNB7; -. DR EnsemblPlants; AT4G16950.1; AT4G16950.1; AT4G16950. [F4JNB7-1] DR GeneID; 827403; -. DR Gramene; AT4G16950.1; AT4G16950.1; AT4G16950. [F4JNB7-1] DR KEGG; ath:AT4G16950; -. DR Araport; AT4G16950; -. DR TAIR; locus:2130270; AT4G16950. DR eggNOG; ENOG410IGA8; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; F4JNB7; -. DR OMA; NETIEMH; -. DR OrthoDB; EOG09360CZB; -. DR PhylomeDB; F4JNB7; -. DR PRO; PR:F4JNB7; -. DR Proteomes; UP000006548; Chromosome 4. DR ExpressionAtlas; F4JNB7; baseline and differential. DR Genevisible; F4JNB7; AT. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0000166; F:nucleotide binding; TAS:TAIR. DR GO; GO:0006952; P:defense response; TAS:TAIR. DR GO; GO:0009817; P:defense response to fungus, incompatible interaction; IMP:TAIR. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 3. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Alternative splicing; ATP-binding; Complete proteome; KW Leucine-rich repeat; Nucleotide-binding; Plant defense; KW Reference proteome; Repeat. FT CHAIN 1 1449 Disease resistance protein RPP5. FT /FTId=PRO_0000433380. FT DOMAIN 10 152 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT DOMAIN 192 446 NB-ARC. {ECO:0000255}. FT REPEAT 549 573 LRR 1. {ECO:0000255}. FT REPEAT 574 595 LRR 2. {ECO:0000255}. FT REPEAT 597 618 LRR 3. {ECO:0000255}. FT REPEAT 619 642 LRR 4. {ECO:0000255}. FT REPEAT 644 665 LRR 5. {ECO:0000255}. FT REPEAT 687 710 LRR 6. {ECO:0000255}. FT REPEAT 712 732 LRR 7. {ECO:0000255}. FT REPEAT 733 755 LRR 8. {ECO:0000255}. FT REPEAT 756 779 LRR 9. {ECO:0000255}. FT REPEAT 802 825 LRR 10. {ECO:0000255}. FT REPEAT 826 849 LRR 11. {ECO:0000255}. FT REPEAT 915 939 LRR 12. {ECO:0000255}. FT REPEAT 941 962 LRR 13. {ECO:0000255}. FT REPEAT 963 985 LRR 14. {ECO:0000255}. FT REPEAT 986 1011 LRR 15. {ECO:0000255}. FT REPEAT 1028 1052 LRR 16. {ECO:0000255}. FT REPEAT 1053 1077 LRR 17. {ECO:0000255}. FT REPEAT 1096 1119 LRR 18. {ECO:0000255}. FT REPEAT 1120 1143 LRR 19. {ECO:0000255}. FT COMPBIAS 4 7 Poly-Ser. {ECO:0000255}. FT CONFLICT 972 972 E -> K (in Ref. 5; BAH19713). FT {ECO:0000305}. SQ SEQUENCE 1449 AA; 164461 MW; A1CD42BD2D37D075 CRC64; MAASSSSGRR RYDVFPSFSG VDVRKTFLSH LIEALDGKSI NTFIDHGIER SRTIAPELIS AIREARISIV IFSKNYASST WCLNELVEIH KCFNDLGQMV IPVFYDVDPS EVRKQTGEFG KVFEKTCEVS KDKQPGDQKQ RWVQALTDIA NIAGEDLLNG PNEAHMVEKI SNDVSNKLIT RSKCFDDFVG IEAHIEAIKS VLCLESKEAR MVGIWGQSGI GKSTIGRALF SQLSIQFPLR AFLTYKSTSG SDVSGMKLSW EKELLSEILG QKDIKIEHFG VVEQRLKHKK VLILLDDVDN LEFLKTLVGK AEWFGSGSRI IVITQDRQFL KAHDIDLVYE VKLPSQGLAL TMLCRSAFGK DSPPDDFKEL AFEVAKLAGH LPLGLNVLGS SLRRRGKKEW MEMMPRLRNG LNGDIMKTLR VSYDRLHQKD QDMFLCIACL FNGFEVSYVK DLLEDNVGLT MLSEKSLIRI TPDGHIEMHN LLEKLGREID RAKSKGNPGK RQFLTNFEDI HEVVTEKTGT ETLLGIRLPF EEYFSTRPLL IDKESFKGMR NLQYLKIGDW SDGGQPQSLV YLPLKLRLLD WDDCPLKSLP STFKAEYLVN LIMKYSKLEK LWEGTLPLGS LKKMNLLCSK NLKEIPDLSN ARNLEELDLE GCESLVTLPS SIQNAIKLRK LHCSGVILID LKSLEGMCNL EYLSVDCSRV EGTQGIVYFP SKLRLLLWNN CPLKRLHSNF KVEYLVKLRM ENSDLEKLWD GTQPLGRLKQ MFLRGSKYLK EIPDLSLAIN LEEVDICKCE SLVTFPSSMQ NAIKLIYLDI SDCKKLESFP TDLNLESLEY LNLTGCPNLR NFPAIKMGCS DVDFPEGRNE IVVEDCFWNK NLPAGLDYLD CLMRCMPCEF RPEYLVFLNV RCYKHEKLWE GIQSLGSLEE MDLSESENLT EIPDLSKATN LKHLYLNNCK SLVTLPSTIG NLQKLVRLEM KECTGLEVLP TDVNLSSLET LDLSGCSSLR TFPLISKSIK WLYLENTAIE EILDLSKATK LESLILNNCK SLVTLPSTIG NLQNLRRLYM KRCTGLEVLP TDVNLSSLGI LDLSGCSSLR TFPLISTNIV WLYLENTAIG EVPCCIEDFT RLRVLLMYCC QRLKNISPNI FRLRSLMFAD FTDCRGVIKA LSDATVVATM EDSVSCVPLS ENIEYTCERF WGELYGDGDW DLGTEYFSFR NCFKLDRDAR ELILRSCFKP VALPGGEIPK YFTYRAYGDS LTVTLPRSSL SQSFLRFKAC LVVDPLSEGK GFYRYLEVNF GFNGKQYQKS FLEDEELEFC KTDHLFFCSF KFESEMTFND VEFKFCCSNR IKECGVRLMY VSQETEYNQQ TTRSKKRMRM TSGTSEEYIN LAGDQIVADT GLAALNMELS LGEGEASSST SLEGEALSVD YMITKEQDED IPFLDPVSDG TWRSFYSAE // ID S7ND80_MYOBR Unreviewed; 461 AA. AC S7ND80; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 25-OCT-2017, entry version 14. DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|EMBL:EPQ15126.1}; GN ORFNames=D623_10022232 {ECO:0000313|EMBL:EPQ15126.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ15126.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KE164108; EPQ15126.1; -; Genomic_DNA. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EPQ15126.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 119 143 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 4 115 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 168 327 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 461 AA; 53008 MW; 0FBE1CF0DC883468 CRC64; MALPTLEHRG NHNHSEFSVK FLVSGDSANL TCRAFFGYSG DVSPLIYWMK GEKFIEDLDE NRVWESDIRI LKEHLGEQEV SISLIVDSVQ EGDLGNYSCY VENGNGRRHA SILLHKRELM YTVELAGGLG AILLLLVCLV TIYKCYKIEI MLFYRNHFGA EELDGDNKDY DAYLSYTKVD PDQWNQETGE EERFALEILP DMLEKHYGYK LFIPDRDLIP TGTYIEDVAR CVDQSKRLII VMTPNYVVRR GWSIFELETR LRNMLVTGEI KVILIECSEL RGIMNYQEVE ALKHTIKLLT VIKWHGPKCN KLNSKFWKRL QYEMPFKRIE PITHEQALDV SEQGPFGELQ TVSAISMAAA TSTALATAHP DLRSNFHNTY HSQMRQKHYY RSYEYDVPPT GTLPLTSIGN QHTYCNIPMT LINGQRPQTK SSREQNPDEA HTNSAILPLL PRETSISSVI W // ID S7NHK2_MYOBR Unreviewed; 1039 AA. AC S7NHK2; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:EPQ16884.1}; GN ORFNames=D623_10004314 {ECO:0000313|EMBL:EPQ16884.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ16884.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KE164308; EPQ16884.1; -; Genomic_DNA. DR RefSeq; XP_005881009.1; XM_005880947.2. DR RefSeq; XP_014384418.1; XM_014528932.1. DR RefSeq; XP_014384419.1; XM_014528933.1. DR GeneID; 102258490; -. DR KEGG; myb:102258490; -. DR CTD; 51311; -. DR KO; K10170; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 17. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:EPQ16884.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 1039 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004554657. FT TRANSMEM 825 846 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 876 1023 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1039 AA; 118704 MW; 1F461BA7F27A0222 CRC64; MTLPSLLLTC LVLLTSDSCG FSTETNYLRR SFPCDEKIQN GSSVIVECNN RRLQEVPQTV GPDVTELDLS DNSITRITNG SFQRLRNLTT INLNRNAMLP PYFENYRRNK KGMSITDGAF LNLQKLTVLL LENNQLDKIP SGLPGSLRWL SLIQNDIISV TKNSTSGLMN LEILNLGWNC YFGNVCNKTF NADGAFEEMA NLKELTLSFN NLSRVPRNLP RSLTKLYLSN TNINAVHGAD LENLGNLTVL DLSGNCPRCF NAPFPCTPCP GDASISIDGN AFDNLTKLEY LNLSSTSLRK INSSWFYKMP HLKELHLEFN YLVQEIASGE FLTKLLSLEI LDLSYNYIKT QYLEFITLSP NFSKLTHLRS LHLRGYVFQK LRYKDFQPLR SLSNLSTINL GVNFINQIDF TIFHNFSELK VIYLSANRIS PLVNGTRQSG ARLSTGHSHV LKPRSADSEF DPHSNFYHST KPLIKPECVH YGKAIDLSLN NIFFIGQKQF KDFPPIACLN LSSNGNGQAL NGSEFSALPH LKYLDFSHNK LDFDADSAFN ELPELEVLDL SNNEHYFQIA GVTHRLGFIK NLTKLKVLNV SQNSIYTLTE YNLSSSSLKQ LVFSGNRLDI LWKAADKRYV CIFRNLNVLE ELDISFNNLE RIPKQAFINL PRNLTKLYLN DNKLRFFNWT LLQHFPQLQL LDLSRNCLYY LTDSLSKITS SLQTLLLSEN IIAHMPTGFV SENSSLVTLD LSSNKLKMIN RSTFQTNKNS NLALLRLDGN PFDCTCDMGD FLRWMDENLN VTIPRLTDVT CSSPGDQIGK SIVTLELTTC VSDTIAAILC FFTSFLTLTV MLAALAHHWF YWDVWFIYHV CLAKVKGYRS LSTSQTFYDA YVSYDTKDAS VTDWVINELR FHLEESEEKN VLLCLEERDW DPGLAIIDNL MQSINQSKKT IFVLTRKYAG SWSFKTAFYL ALQRLMDENM DVIVFILLEP VLQHSQYLRL RQRICKSSIL QWPDNPKAEV LFWQSLKNVV LTENNSRYNN LYVDSIKQY // ID S7P5W9_MYOBR Unreviewed; 583 AA. AC S7P5W9; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Interleukin-18 receptor accessory protein {ECO:0000313|EMBL:EPQ03047.1}; GN ORFNames=D623_10006598 {ECO:0000313|EMBL:EPQ03047.1}; OS Myotis brandtii (Brandt's bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; OC Vespertilionidae; Myotis. OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ03047.1, ECO:0000313|Proteomes:UP000052978}; RN [1] {ECO:0000313|Proteomes:UP000052978} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23962925; DOI=10.1038/ncomms3212; RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., RA Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., RA Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., RA Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.; RT "Genome analysis reveals insights into physiology and longevity of the RT Brandt's bat Myotis brandtii."; RL Nat. Commun. 4:2212-2212(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KE161316; EPQ03047.1; -; Genomic_DNA. DR RefSeq; XP_005858807.2; XM_005858745.2. DR RefSeq; XP_014388547.1; XM_014533061.1. DR GeneID; 102262632; -. DR KEGG; myb:102262632; -. DR CTD; 8807; -. DR KO; K05174; -. DR Proteomes; UP000052978; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000052978}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:EPQ03047.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000052978}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 583 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004543539. FT TRANSMEM 358 385 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 148 237 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 250 352 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 405 561 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 583 AA; 65512 MW; 119FCEC68467776D CRC64; MLCLGWIFLW FVTGERIKGF NISGCSIKNF LWMYSAESTE EFVLFCDLAE PQKPRSYHRH PLSPAQGPAR RPCRGREGLS DAQWYLQPRE GGALKEITSN QSHLLLDKTA LRFLTAERSH AGSYICRPRM RSRRDEACCV KMVLEVQPQA DLSCARPVPR TRYLRLGSTD SIHCPSLGCQ GGTPSPEMTW YQNGRLLSAQ RSNPLQLDVI YDYHQGTYAC DYAQADGAGS RTVRAVVQVK TIVRNTTLKP DILEPVKDTL EVELGKPLTL NCTARFGFEE HFKPVLRWFS KDSGRELEIP TKEGRRVKAT VEAEVIQRTV HLERVAQSDL HKTFICFAQN SLGNSTQPLQ LRGRKGVVFL YVLLGTVAAL AGALAAGALL FTYWIEVVLL CRTCQDKDET LGDKKEFDAF ISYAKGSASE SEPASPVSED CLALKLFPEV LENKYGYTLC LLERDVAPGG VYTEDIVSII KKSRRGVFIL SPNYVNGPSV FELQAAVSLA LDDQTLKLIL VKFCPFQEPE SLPDLVRKAL RVLPTVTWRG LKSAPPNSRF WTRMRYHMPM KNPTGLPWGH LRVISRAFSL GRQ // ID T1GEJ0_MEGSC Unreviewed; 1179 AA. AC T1GEJ0; DT 16-OCT-2013, integrated into UniProtKB/TrEMBL. DT 16-OCT-2013, sequence version 1. DT 28-MAR-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:MESCA001754-PA}; OS Megaselia scalaris (Humpbacked fly) (Phora scalaris). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Platypezoidea; Phoridae; Megaseliini; Megaselia. OX NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA001754-PA, ECO:0000313|Proteomes:UP000015102}; RN [1] {ECO:0000313|EnsemblMetazoa:MESCA001754-PA, ECO:0000313|Proteomes:UP000015102} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Durham, and RC NC isolate 2 -- Noor lab {ECO:0000313|EnsemblMetazoa:MESCA001754-PA}; RA Hughes D.; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:MESCA001754-PA} RP IDENTIFICATION. RG EnsemblMetazoa; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CAQQ02393984; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EnsemblMetazoa; MESCA001754-RA; MESCA001754-PA; MESCA001754. DR OMA; NHAFIGR; -. DR Proteomes; UP000015102; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 6. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 16. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 16. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000015102}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000015102}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 1179 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004577278. FT TRANSMEM 814 837 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 863 1003 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1179 AA; 134476 MW; 07981763B79B847E CRC64; MDYKFVVALI AILSLFGCPF TSLATAANQC SLEFNGTTSV TCNIRTIDKS GLDLLAADGT SRLDIKCNDV FLFESQLPQN VFARLQTLEE LSIESCKLLQ LPNNAFEGLS ATKVLKVRTK NSEWGLGKSL ELFPDSLIGL KQLTALHLKN LGFTNMVCNG GSELQVLDLS YNELKTIPEN WGVSRFRRLQ HLNLQNNNIT ELHAESFAGL SSLRVINVSN NHLETLPIGL FAGSKELREI HLQHNELYEL PKGLFHRLEQ LLVLDLSSNQ LTSHHVDNTT FAGLIRLIVL NLANNALTRI DYRTFKELYF LQILNLRNNS IGHIEDNAFL PLYNLHTLNL AENRLHTLDD KLFNGLYVLS KLTLNNNLIS VIEGSVFKNC SDLKELDLSS NQLTDVPEAI QDLAMLRTLD LGENQISTFT NGSFRNLHQL TGLRLIDNRI GNITVGMFWD LPRLSVLNLA KNRIQSIERG SFDRMWKSKQ FDWIEISCQI LMPNTFVHKG NLARVDLYAN ALNQLQLQLL RIAKIDEEQP QPEFYLGGNP FQCDCSMEWL QRINNMTTGH YPKVMDLQNI ECMMPHARGS PQRPLTSLKS KDFLCRYEAH CFALCHCCDF DACDCEMTCP SNCTCYHDQT WGTNVVDCGG YQTSNLPKRV PMDSTIVYLD GNMFPILDNH AFIGRKNLRE LYVNNSGVTS IKPKTFSGLT SLAILHLEDN KLKVLRLDGN KLHSIPIWQM QLSQFKTNIK SLYLGGNEWS CRCKFLQELT TFVADNALII QDSQDIYCMD AVTGKKELDF NATSACSDYY AGGSVLQNGI PKTYLPLLAV ALIFIFLFVI LIVIFVFREP LRIWLFAHYG VRVFGPRCEE SEKLYDAVLL HSAKDTEFVM QCLITELEAG RPPLRICLQH RDLSHEATHF QVLEAARVSR RVIILLTRNF LQTEWSRCEL RRAVHDALRG RPHKLVIIEE PDVCLEAEMD VELVPYLKTS GVNRIRRNDR HFWEKLRYAL PVDFPYRGNN YTIDHMTHEP PPPAYCPDGE DPNYSSATTA TPSPRPSRRA VELLQAQFPQ MSHHPNPHYQ QSGHVRPPSE HIYSSIDSDY STLDNENVMM MPQQQAAVNS LHRSMHQHQQ QPQYNPHHTW RPAPSQDMQL QKQQQQQHHQ QQQQQTPQQT TPQEVVPGQQ GPHVQAYLV // ID TLR10_HUMAN Reviewed; 811 AA. AC Q9BXR5; A8K7L1; B3Y668; D1CS21; D1CS22; Q32MI7; Q32MI8; Q5FWG4; AC Q6UXL3; DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 17-OCT-2006, sequence version 2. DT 28-FEB-2018, entry version 159. DE RecName: Full=Toll-like receptor 10; DE AltName: CD_antigen=CD290; DE Flags: Precursor; GN Name=TLR10; ORFNames=UNQ315/PRO358; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Spleen; RX PubMed=11267672; DOI=10.1016/S0167-4781(00)00289-X; RA Chuang T.-H., Ulevitch R.J.; RT "Identification of hTLR10: a novel human Toll-like receptor RT preferentially expressed in immune cells."; RL Biochim. Biophys. Acta 1518:157-161(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=18810425; DOI=10.1007/s00251-008-0332-0; RA Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., RA Kimura A.; RT "Natural selection in the TLR-related genes in the course of primate RT evolution."; RL Immunogenetics 60:727-735(2008). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-381. RX PubMed=19924287; DOI=10.1371/journal.pone.0007803; RA Georgel P., Macquin C., Bahram S.; RT "The heterogeneous allelic repertoire of human Toll-Like receptor RT (TLR) genes."; RL PLoS ONE 4:E7803-E7803(2009). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-241; LEU-369 RP AND VAL-775. RC TISSUE=Spleen; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-241; LEU-369; RP THR-473 AND VAL-775. RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 622-776, AND SUBUNIT. RX PubMed=18332149; DOI=10.1074/jbc.C800001200; RA Nyman T., Stenmark P., Flodin S., Johansson I., Hammarstrom M., RA Nordlund P.; RT "The crystal structure of the human toll-like receptor 10 cytoplasmic RT domain reveals a putative signaling dimer."; RL J. Biol. Chem. 283:11861-11865(2008). CC -!- FUNCTION: Participates in the innate immune response to microbial CC agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B CC activation, cytokine secretion and the inflammatory response (By CC similarity). {ECO:0000250}. CC -!- SUBUNIT: Binds MYD88 via their respective TIR domains (By CC similarity). Homodimer (Potential). {ECO:0000250, ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I CC membrane protein {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, CC thymus, tonsil and at lower levels in lung. Highly expressed in CC promyelocytic HL-60 cells and in B-cell lines. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF296673; AAK26744.1; -; mRNA. DR EMBL; AB445680; BAG55077.1; -; mRNA. DR EMBL; DQ011504; AAY78479.1; -; mRNA. DR EMBL; DQ011505; AAY78480.1; -; mRNA. DR EMBL; AY358300; AAQ88667.1; -; mRNA. DR EMBL; AK292026; BAF84715.1; -; mRNA. DR EMBL; CH471069; EAW92897.1; -; Genomic_DNA. DR EMBL; BC089406; AAH89406.1; -; mRNA. DR EMBL; BC109111; AAI09112.1; -; mRNA. DR EMBL; BC109112; AAI09113.1; -; mRNA. DR CCDS; CCDS3445.1; -. DR RefSeq; NP_001017388.1; NM_001017388.2. DR RefSeq; NP_001182035.1; NM_001195106.1. DR RefSeq; NP_001182036.1; NM_001195107.1. DR RefSeq; NP_001182037.1; NM_001195108.1. DR RefSeq; NP_112218.2; NM_030956.3. DR RefSeq; XP_011512063.1; XM_011513761.2. DR RefSeq; XP_011512064.1; XM_011513762.2. DR UniGene; Hs.120551; -. DR UniGene; Hs.730896; -. DR PDB; 2J67; X-ray; 2.20 A; A/B=622-776. DR PDBsum; 2J67; -. DR ProteinModelPortal; Q9BXR5; -. DR SMR; Q9BXR5; -. DR BioGrid; 123585; 10. DR STRING; 9606.ENSP00000308925; -. DR iPTMnet; Q9BXR5; -. DR PhosphoSitePlus; Q9BXR5; -. DR BioMuta; TLR10; -. DR DMDM; 116242819; -. DR PaxDb; Q9BXR5; -. DR PeptideAtlas; Q9BXR5; -. DR PRIDE; Q9BXR5; -. DR Ensembl; ENST00000308973; ENSP00000308925; ENSG00000174123. DR Ensembl; ENST00000361424; ENSP00000354459; ENSG00000174123. DR Ensembl; ENST00000506111; ENSP00000421483; ENSG00000174123. DR Ensembl; ENST00000508334; ENSP00000424923; ENSG00000174123. DR Ensembl; ENST00000613579; ENSP00000478206; ENSG00000174123. DR Ensembl; ENST00000622002; ENSP00000478985; ENSG00000174123. DR GeneID; 81793; -. DR KEGG; hsa:81793; -. DR UCSC; uc003gti.3; human. DR CTD; 81793; -. DR DisGeNET; 81793; -. DR EuPathDB; HostDB:ENSG00000174123.10; -. DR GeneCards; TLR10; -. DR HGNC; HGNC:15634; TLR10. DR MIM; 606270; gene. DR neXtProt; NX_Q9BXR5; -. DR OpenTargets; ENSG00000174123; -. DR PharmGKB; PA38011; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000008676; -. DR HOVERGEN; HBG023180; -. DR InParanoid; Q9BXR5; -. DR KO; K10171; -. DR OMA; AYLEWPK; -. DR OrthoDB; EOG091G0356; -. DR PhylomeDB; Q9BXR5; -. DR TreeFam; TF351113; -. DR Reactome; R-HSA-168142; Toll Like Receptor 10 (TLR10) Cascade. DR Reactome; R-HSA-5603037; IRAK4 deficiency (TLR5). DR Reactome; R-HSA-975871; MyD88 cascade initiated on plasma membrane. DR EvolutionaryTrace; Q9BXR5; -. DR GeneWiki; TLR10; -. DR GenomeRNAi; 81793; -. DR PRO; PR:Q9BXR5; -. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000174123; -. DR CleanEx; HS_TLR10; -. DR ExpressionAtlas; Q9BXR5; baseline and differential. DR Genevisible; Q9BXR5; HS. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0016020; C:membrane; TAS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:UniProtKB. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027182; TLR10. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF23; PTHR24365:SF23; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 4. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 9. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Glycoprotein; Immunity; KW Inflammatory response; Innate immunity; Leucine-rich repeat; Membrane; KW Polymorphism; Receptor; Reference proteome; Repeat; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 19 {ECO:0000255}. FT CHAIN 20 811 Toll-like receptor 10. FT /FTId=PRO_0000034739. FT TOPO_DOM 20 576 Extracellular. {ECO:0000255}. FT TRANSMEM 577 597 Helical. {ECO:0000255}. FT TOPO_DOM 598 811 Cytoplasmic. {ECO:0000255}. FT REPEAT 24 46 LRR 1. FT REPEAT 49 70 LRR 2. FT REPEAT 73 94 LRR 3. FT REPEAT 97 118 LRR 4. FT REPEAT 119 139 LRR 5. FT REPEAT 143 166 LRR 6. FT REPEAT 296 321 LRR 7. FT REPEAT 325 348 LRR 8. FT REPEAT 349 368 LRR 9. FT REPEAT 373 394 LRR 10. FT REPEAT 398 419 LRR 11. FT REPEAT 422 442 LRR 12. FT REPEAT 444 465 LRR 13. FT REPEAT 467 488 LRR 14. FT REPEAT 489 509 LRR 15. FT DOMAIN 522 576 LRRCT. FT DOMAIN 632 778 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 33 33 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 36 36 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 140 140 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 189 189 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 236 236 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 278 278 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 330 330 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 416 416 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 427 427 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT VARIANT 163 163 A -> S (in dbSNP:rs11466649). FT /FTId=VAR_024669. FT VARIANT 167 167 L -> P (in dbSNP:rs11466650). FT /FTId=VAR_028125. FT VARIANT 241 241 N -> H (in dbSNP:rs11096957). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_024670. FT VARIANT 298 298 V -> I (in dbSNP:rs11466651). FT /FTId=VAR_028126. FT VARIANT 326 326 M -> T (in dbSNP:rs11466653). FT /FTId=VAR_024671. FT VARIANT 369 369 I -> L (in dbSNP:rs11096955). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_024672. FT VARIANT 381 381 G -> D (in dbSNP:rs11466655). FT {ECO:0000269|PubMed:19924287}. FT /FTId=VAR_024673. FT VARIANT 469 469 R -> G (in dbSNP:rs11466656). FT /FTId=VAR_028127. FT VARIANT 473 473 I -> T (in dbSNP:rs11466657). FT {ECO:0000269|PubMed:15489334}. FT /FTId=VAR_028128. FT VARIANT 525 525 R -> W (in dbSNP:rs11466658). FT /FTId=VAR_024674. FT VARIANT 736 736 Y -> C (in dbSNP:rs11466660). FT /FTId=VAR_028129. FT VARIANT 775 775 I -> F (in dbSNP:rs4129009). FT /FTId=VAR_059832. FT VARIANT 775 775 I -> L (in dbSNP:rs4129009). FT /FTId=VAR_028130. FT VARIANT 775 775 I -> V (in dbSNP:rs4129009). FT {ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_059833. FT VARIANT 799 799 R -> L (in dbSNP:rs4129008). FT /FTId=VAR_059834. FT VARIANT 799 799 R -> P (in dbSNP:rs4129008). FT /FTId=VAR_059835. FT VARIANT 799 799 R -> Q (in dbSNP:rs4129008). FT /FTId=VAR_028131. FT CONFLICT 96 96 K -> R (in Ref. 5; BAF84715). FT {ECO:0000305}. FT CONFLICT 562 562 T -> I (in Ref. 1; AAK26744). FT {ECO:0000305}. FT STRAND 634 639 {ECO:0000244|PDB:2J67}. FT HELIX 642 644 {ECO:0000244|PDB:2J67}. FT HELIX 645 650 {ECO:0000244|PDB:2J67}. FT HELIX 652 656 {ECO:0000244|PDB:2J67}. FT HELIX 668 671 {ECO:0000244|PDB:2J67}. FT HELIX 678 687 {ECO:0000244|PDB:2J67}. FT STRAND 689 696 {ECO:0000244|PDB:2J67}. FT HELIX 698 703 {ECO:0000244|PDB:2J67}. FT HELIX 705 707 {ECO:0000244|PDB:2J67}. FT HELIX 709 712 {ECO:0000244|PDB:2J67}. FT TURN 717 719 {ECO:0000244|PDB:2J67}. FT STRAND 725 731 {ECO:0000244|PDB:2J67}. FT HELIX 735 737 {ECO:0000244|PDB:2J67}. FT HELIX 743 750 {ECO:0000244|PDB:2J67}. FT STRAND 754 756 {ECO:0000244|PDB:2J67}. FT HELIX 761 763 {ECO:0000244|PDB:2J67}. FT HELIX 764 775 {ECO:0000244|PDB:2J67}. SQ SEQUENCE 811 AA; 94564 MW; 6BFAAEF76886BFBA CRC64; MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD LPGCSHFSRL SVLNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVL ATREMYELQT FTELNEESRG STISLMRTDC L // ID TLR13_MOUSE Reviewed; 991 AA. AC Q6R5N8; Q148Y7; Q3TDS2; DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 28-FEB-2018, entry version 118. DE RecName: Full=Toll-like receptor 13; DE Flags: Precursor; GN Name=Tlr13; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/6J; RX PubMed=14993594; DOI=10.1073/pnas.0400525101; RA Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., RA Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., RA Beutler B.; RT "Toll-like receptors 9 and 3 as essential components of innate immune RT defense against mouse cytomegalovirus infection."; RL Proc. Natl. Acad. Sci. U.S.A. 101:3516-3521(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-682. RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH UNC93B1. RX PubMed=17452530; DOI=10.1083/jcb.200612056; RA Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., RA Kim Y.M.; RT "The interaction between the ER membrane protein UNC93B and TLR3, 7, RT and 9 is crucial for TLR signaling."; RL J. Cell Biol. 177:265-275(2007). RN [7] RP FUNCTION. RX PubMed=21131352; DOI=10.1074/jbc.M110.159590; RA Shi Z., Cai Z., Sanchez A., Zhang T., Wen S., Wang J., Yang J., Fu S., RA Zhang D.; RT "A novel Toll-like receptor that recognizes vesicular stomatitis RT virus."; RL J. Biol. Chem. 286:4517-4524(2011). RN [8] RP FUNCTION, AND RNA-BINDING. RX PubMed=22821982; DOI=10.1126/science.1220363; RA Oldenburg M., Kruger A., Ferstl R., Kaufmann A., Nees G., Sigmund A., RA Bathke B., Lauterbach H., Suter M., Dreher S., Koedel U., Akira S., RA Kawai T., Buer J., Wagner H., Bauer S., Hochrein H., Kirschning C.J.; RT "TLR13 recognizes bacterial 23S rRNA devoid of erythromycin RT resistance-forming modification."; RL Science 337:1111-1115(2012). RN [9] RP FUNCTION, RNA-BINDING, AND SUBCELLULAR LOCATION. RX PubMed=22896636; DOI=10.4049/jimmunol.1200898; RA Hidmark A., von Saint Paul A., Dalpke A.H.; RT "TLR13 Is a Receptor for Bacterial RNA."; RL J. Immunol. 189:2717-2721(2012). CC -!- FUNCTION: Component of innate and adaptive immunity that CC recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like CC receptors) control host immune response against pathogens through CC recognition of molecular patterns specific to microorganisms. Acts CC via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine CC secretion and the inflammatory response. Specifically binds the CC 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also CC bound by MLS group antibiotics (including erythromycin). May also CC recognize vesicular stomatitis virus; however, these data require CC additional evidences. {ECO:0000269|PubMed:21131352, CC ECO:0000269|PubMed:22821982, ECO:0000269|PubMed:22896636}. CC -!- SUBUNIT: Binds MYD88 via their respective TIR domains (By CC similarity). Interacts with UNC93B1. {ECO:0000250, CC ECO:0000269|PubMed:17452530}. CC -!- INTERACTION: CC Self; NbExp=4; IntAct=EBI-16173901, EBI-16173901; CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000269|PubMed:22896636}; Single-pass type I membrane protein CC {ECO:0000269|PubMed:22896636}. CC -!- MISCELLANEOUS: The sequence 23S rRNA from clinical isolates of CC erythromycin-resistant S.aureus is methylated and is not CC recognized by Tlr13 anymore, suggesting a link between antibiotic CC resistance and evasion from Tlr13 recognition. 23S rRNA CC modifications generating resistance toward MLS antibiotics CC preventing recognition of bacteria from Tlr13. These data may also CC explain why Tlr13 is not conserved in human: human may instead CC possess a related rRNA-sensing pattern recognition receptor that CC has evolved to recognize species that can hide from Tlr13 owing to CC rRNA modifications (PubMed:22821982). CC {ECO:0000305|PubMed:22821982}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAE41528.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AY510706; AAS37674.1; -; mRNA. DR EMBL; AK170044; BAE41528.1; ALT_INIT; mRNA. DR EMBL; AL672288; CAM16892.1; -; Genomic_DNA. DR EMBL; CH466564; EDL14060.1; -; Genomic_DNA. DR EMBL; BC117913; AAI17914.1; -; mRNA. DR EMBL; BC117914; AAI17915.1; -; mRNA. DR CCDS; CCDS30338.1; -. DR RefSeq; NP_991389.1; NM_205820.1. DR UniGene; Mm.336203; -. DR PDB; 4Z0C; X-ray; 2.30 A; A/D=69-777. DR PDBsum; 4Z0C; -. DR ProteinModelPortal; Q6R5N8; -. DR SMR; Q6R5N8; -. DR DIP; DIP-61832N; -. DR STRING; 10090.ENSMUSP00000043101; -. DR iPTMnet; Q6R5N8; -. DR PhosphoSitePlus; Q6R5N8; -. DR MaxQB; Q6R5N8; -. DR PaxDb; Q6R5N8; -. DR PeptideAtlas; Q6R5N8; -. DR PRIDE; Q6R5N8; -. DR Ensembl; ENSMUST00000040065; ENSMUSP00000043101; ENSMUSG00000033777. DR GeneID; 279572; -. DR KEGG; mmu:279572; -. DR UCSC; uc009ubn.1; mouse. DR CTD; 279572; -. DR MGI; MGI:3045213; Tlr13. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000203220; -. DR HOVERGEN; HBG094977; -. DR InParanoid; Q6R5N8; -. DR KO; K18808; -. DR OMA; PLFWARI; -. DR OrthoDB; EOG091G018G; -. DR PhylomeDB; Q6R5N8; -. DR TreeFam; TF325595; -. DR PRO; PR:Q6R5N8; -. DR Proteomes; UP000000589; Chromosome X. DR Bgee; ENSMUSG00000033777; -. DR CleanEx; MM_TLR13; -. DR Genevisible; Q6R5N8; MM. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005768; C:endosome; IDA:UniProtKB. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0042803; F:protein homodimerization activity; IDA:MGI. DR GO; GO:0004872; F:receptor activity; IBA:GO_Central. DR GO; GO:0019843; F:rRNA binding; IDA:UniProtKB. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IDA:UniProtKB. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IGI:MGI. DR GO; GO:0043408; P:regulation of MAPK cascade; IGI:MGI. DR GO; GO:0009615; P:response to virus; IMP:MGI. DR GO; GO:0034178; P:toll-like receptor 13 signaling pathway; IDA:UniProtKB. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR025875; Leu-rich_rpt_4. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF12799; LRR_4; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 18. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Endosome; Glycoprotein; Immunity; KW Inflammatory response; Innate immunity; Leucine-rich repeat; Membrane; KW Receptor; Reference proteome; Repeat; RNA-binding; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 68 {ECO:0000255}. FT CHAIN 69 991 Toll-like receptor 13. FT /FTId=PRO_0000042795. FT TOPO_DOM 69 783 Extracellular. {ECO:0000255}. FT TRANSMEM 784 804 Helical. {ECO:0000255}. FT TOPO_DOM 805 991 Cytoplasmic. {ECO:0000255}. FT REPEAT 104 125 LRR 1. FT REPEAT 128 149 LRR 2. FT REPEAT 152 174 LRR 3. FT REPEAT 175 196 LRR 4. FT REPEAT 199 220 LRR 5. FT REPEAT 225 246 LRR 6. FT REPEAT 248 268 LRR 7. FT REPEAT 271 292 LRR 8. FT REPEAT 295 315 LRR 9. FT REPEAT 318 338 LRR 10. FT REPEAT 348 368 LRR 11. FT REPEAT 372 394 LRR 12. FT REPEAT 397 418 LRR 13. FT REPEAT 421 442 LRR 14. FT REPEAT 445 466 LRR 15. FT REPEAT 469 490 LRR 16. FT REPEAT 493 514 LRR 17. FT REPEAT 517 538 LRR 18. FT REPEAT 541 562 LRR 19. FT REPEAT 565 585 LRR 20. FT REPEAT 594 617 LRR 21. FT REPEAT 620 641 LRR 22. FT REPEAT 644 665 LRR 23. FT REPEAT 672 693 LRR 24. FT REPEAT 696 716 LRR 25. FT DOMAIN 729 779 LRRCT. FT DOMAIN 832 978 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 93 93 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 109 109 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 125 125 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 152 152 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 167 167 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 209 209 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 233 233 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 263 263 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 271 271 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 274 274 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 300 300 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 310 310 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 357 357 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 388 388 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 413 413 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 421 421 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 644 644 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 663 663 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 711 711 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 742 742 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT STRAND 75 77 {ECO:0000244|PDB:4Z0C}. FT STRAND 80 85 {ECO:0000244|PDB:4Z0C}. FT HELIX 94 98 {ECO:0000244|PDB:4Z0C}. FT STRAND 107 109 {ECO:0000244|PDB:4Z0C}. FT TURN 120 125 {ECO:0000244|PDB:4Z0C}. FT STRAND 131 133 {ECO:0000244|PDB:4Z0C}. FT TURN 144 149 {ECO:0000244|PDB:4Z0C}. FT STRAND 155 157 {ECO:0000244|PDB:4Z0C}. FT STRAND 178 180 {ECO:0000244|PDB:4Z0C}. FT TURN 191 196 {ECO:0000244|PDB:4Z0C}. FT STRAND 202 204 {ECO:0000244|PDB:4Z0C}. FT HELIX 213 220 {ECO:0000244|PDB:4Z0C}. FT STRAND 228 230 {ECO:0000244|PDB:4Z0C}. FT STRAND 251 253 {ECO:0000244|PDB:4Z0C}. FT STRAND 274 276 {ECO:0000244|PDB:4Z0C}. FT STRAND 298 300 {ECO:0000244|PDB:4Z0C}. FT HELIX 308 310 {ECO:0000244|PDB:4Z0C}. FT HELIX 313 316 {ECO:0000244|PDB:4Z0C}. FT STRAND 321 323 {ECO:0000244|PDB:4Z0C}. FT HELIX 329 331 {ECO:0000244|PDB:4Z0C}. FT HELIX 336 343 {ECO:0000244|PDB:4Z0C}. FT STRAND 351 353 {ECO:0000244|PDB:4Z0C}. FT HELIX 361 370 {ECO:0000244|PDB:4Z0C}. FT STRAND 374 377 {ECO:0000244|PDB:4Z0C}. FT TURN 391 394 {ECO:0000244|PDB:4Z0C}. FT STRAND 399 402 {ECO:0000244|PDB:4Z0C}. FT STRAND 424 426 {ECO:0000244|PDB:4Z0C}. FT TURN 437 442 {ECO:0000244|PDB:4Z0C}. FT STRAND 448 450 {ECO:0000244|PDB:4Z0C}. FT HELIX 461 464 {ECO:0000244|PDB:4Z0C}. FT STRAND 472 474 {ECO:0000244|PDB:4Z0C}. FT STRAND 496 498 {ECO:0000244|PDB:4Z0C}. FT TURN 509 514 {ECO:0000244|PDB:4Z0C}. FT STRAND 520 522 {ECO:0000244|PDB:4Z0C}. FT TURN 533 538 {ECO:0000244|PDB:4Z0C}. FT STRAND 544 546 {ECO:0000244|PDB:4Z0C}. FT TURN 557 562 {ECO:0000244|PDB:4Z0C}. FT STRAND 568 570 {ECO:0000244|PDB:4Z0C}. FT STRAND 578 580 {ECO:0000244|PDB:4Z0C}. FT TURN 588 591 {ECO:0000244|PDB:4Z0C}. FT STRAND 597 599 {ECO:0000244|PDB:4Z0C}. FT TURN 612 617 {ECO:0000244|PDB:4Z0C}. FT STRAND 623 625 {ECO:0000244|PDB:4Z0C}. FT STRAND 632 634 {ECO:0000244|PDB:4Z0C}. FT TURN 638 641 {ECO:0000244|PDB:4Z0C}. FT STRAND 647 649 {ECO:0000244|PDB:4Z0C}. FT HELIX 656 659 {ECO:0000244|PDB:4Z0C}. FT STRAND 660 662 {ECO:0000244|PDB:4Z0C}. FT TURN 664 669 {ECO:0000244|PDB:4Z0C}. FT STRAND 675 677 {ECO:0000244|PDB:4Z0C}. FT STRAND 699 701 {ECO:0000244|PDB:4Z0C}. FT TURN 712 717 {ECO:0000244|PDB:4Z0C}. FT STRAND 723 725 {ECO:0000244|PDB:4Z0C}. FT HELIX 735 737 {ECO:0000244|PDB:4Z0C}. FT HELIX 738 746 {ECO:0000244|PDB:4Z0C}. FT HELIX 755 757 {ECO:0000244|PDB:4Z0C}. FT HELIX 769 771 {ECO:0000244|PDB:4Z0C}. FT HELIX 774 776 {ECO:0000244|PDB:4Z0C}. SQ SEQUENCE 991 AA; 114443 MW; 6FB622DC62F37E74 CRC64; MSGLYRILVQ LEQSPYVKTV PLNMRRDFFF LVVTWMPKTV KMNGSSFVPS LQLLLMLVGF SLPPVAETYG FNKCTQYEFD IHHVLCIRKK ITNLTEAISD IPRYTTHLNL THNEIQVLPP WSFTNLSALV DLRLEWNSIW KIDEGAFRGL ENLTLLNLVE NKIQSVNNSF EGLSSLKTLL LSHNQITHIH KDAFTPLIKL KYLSLSRNNI SDFSGILEAV QHLPCLERLD LTNNSIMYLD HSPRSLVSLT HLSFEGNKLR ELNFSALSLP NLTNLSASRN GNKVIQNVYL KTLPQLKSLN LSGTVIKLEN LSAKHLQNLR AMDLSNWELR HGHLDMKTVC HLLGNLPKLE TLVFQKNVTN AEGIKQLAKC TRLLFLDLGQ NSDLIYLNDS EFNALPSLQK LNLNKCQLSF INNRTWSSLQ NLTSLDLSHN KFKSFPDFAF SPLKHLEFLS LSRNPITELN NLAFSGLFAL KELNLAACWI VTIDRYSFTQ FPNLEVLDLG DNNIRTLNHG TFRPLKKLQS LILSHNCLKI LEPNSFSGLT NLRSLDLMYN SLSYFHEHLF SGLEKLLILK LGFNKITYET TRTLQYPPFI KLKSLKQLNL EGQRHGIQVV PSNFFQGLGS LQELLLGKNP SVFLDHHQFD PLINLTKLDI SGTKDGDRSL YLNASLFQNL KRLKILRLEN NNLESLVPDM FSSLQSLQVF SLRFNNLKVI NQSHLKNLKS LMFFDVYGNK LQCTCDNLWF KNWSMNTEEV HIPFLRSYPC QQPGSQSLLI DFDDAMCNFD LGKVYFLCSF SMVLSTMVFS WFSTKMIASL WYGLYICRAW YLTKWHKTEK KFLYDAFVSF SATDEAWVYK ELVPALEQGS QTTFKLCLHQ RDFEPGIDIF ENIQNAINTS RKTLCVVSNH YLHSEWCRLE VQLASMKMFY EHKDVIILIF LEEIPNYKLS SYHRLRKLIN KQTFITWPDS VHQQPLFWAR IRNALGKETV EKENTHLIVV E // ID TLR3_MOUSE Reviewed; 905 AA. AC Q99MB1; Q91ZM4; DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 31-JAN-2002, sequence version 2. DT 28-MAR-2018, entry version 161. DE RecName: Full=Toll-like receptor 3; DE AltName: CD_antigen=CD283; DE Flags: Precursor; GN Name=Tlr3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=129/Sv; RX PubMed=11607032; DOI=10.1038/35099560; RA Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A.; RT "Recognition of double-stranded RNA and activation of NF-kappaB by RT Toll-like receptor 3."; RL Nature 413:732-738(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=BALB/c X NIH; TISSUE=Macrophage; RA Applequist S.E., Ljunggren H.G.; RT "Molecular cloning of mouse Toll-like receptor 3 cDNA."; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP FUNCTION IN CYTOMEGALOVIRUS INFECTION. RX PubMed=14993594; DOI=10.1073/pnas.0400525101; RA Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., RA Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., RA Beutler B.; RT "Toll-like receptors 9 and 3 as essential components of innate immune RT defense against mouse cytomegalovirus infection."; RL Proc. Natl. Acad. Sci. U.S.A. 101:3516-3521(2004). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH UNC93B1. RX PubMed=17452530; DOI=10.1083/jcb.200612056; RA Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., RA Kim Y.M.; RT "The interaction between the ER membrane protein UNC93B and TLR3, 7, RT and 9 is crucial for TLR signaling."; RL J. Cell Biol. 177:265-275(2007). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [7] RP INTERACTION WITH WDFY1 AND TICAM1. RX PubMed=25736436; DOI=10.15252/embr.201439637; RA Hu Y.H., Zhang Y., Jiang L.Q., Wang S., Lei C.Q., Sun M.S., Shu H.B., RA Liu Y.; RT "WDFY1 mediates TLR3/4 signaling by recruiting TRIF."; RL EMBO Rep. 16:447-455(2015). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.66 ANGSTROMS) OF 28-704 IN COMPLEX WITH RP DS-RNA, SUBUNIT, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-71; RP ASN-197; ASN-253; ASN-276; ASN-292; ASN-399; ASN-414; ASN-425; RP ASN-508; ASN-663 AND ASN-668. RX PubMed=18420935; DOI=10.1126/science.1155406; RA Liu L., Botos I., Wang Y., Leonard J.N., Shiloach J., Segal D.M., RA Davies D.R.; RT "Structural basis of toll-like receptor 3 signaling with double- RT stranded RNA."; RL Science 320:379-381(2008). CC -!- FUNCTION: Key component of innate and adaptive immunity. TLRs CC (Toll-like receptors) control host immune response against CC pathogens through recognition of molecular patterns specific to CC microorganisms. TLR3 is a nucleotide-sensing TLR which is CC activated by double-stranded RNA, a sign of viral infection. Acts CC via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, CC IRF3 nuclear translocation, cytokine secretion and the CC inflammatory response (By similarity). {ECO:0000250, CC ECO:0000269|PubMed:14993594}. CC -!- SUBUNIT: Monomer and homodimer; dimerization is triggered by CC ligand-binding, the signaling unit is composed of one ds-RNA of CC around 40 bp and two TLR3 molecules, and lateral clustering of CC signaling units along the length of the ds-RNA ligand is required CC for TLR3 signal transduction. Interacts (via transmembrane domain) CC with UNC93B1; the interaction is required for transport from the CC ER to the endosomes. Interacts with SRC; upon binding of double- CC stranded RNA (By similarity). Interacts with TICAM1 (via the TIR CC domain) in response to poly(I:C) and this interaction is enhanced CC in the presence of WDFY1 (PubMed:25736436). The tyrosine- CC phosphorylated form (via TIR domain) interacts with WDFY1 (via WD CC repeat 2) in response to poly(I:C) (PubMed:25736436). CC {ECO:0000250|UniProtKB:O15455, ECO:0000269|PubMed:25736436}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass CC type I membrane protein. Endosome membrane CC {ECO:0000250|UniProtKB:O15455}. Early endosome CC {ECO:0000250|UniProtKB:O15455}. CC -!- TISSUE SPECIFICITY: Highly expressed in lung. After CC intraperitoneal injection of lipopolysaccharide, highly expressed CC in brain, heart, kidney, liver, lung and spleen. CC -!- DOMAIN: ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to CC 18. CC -!- PTM: TLR3 signaling requires a proteolytic cleavage mediated by CC cathepsins CTSB and CTSH, the cleavage occurs between amino acids CC 252 and 346. The cleaved form of TLR3 is the predominant form CC found in endosomes (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF420279; AAL27007.1; -; mRNA. DR EMBL; AF355152; AAK26117.1; -; mRNA. DR EMBL; AK083977; BAC39082.1; -; mRNA. DR CCDS; CCDS22278.1; -. DR RefSeq; NP_569054.2; NM_126166.4. DR RefSeq; XP_006509341.1; XM_006509278.3. DR RefSeq; XP_006509342.1; XM_006509279.2. DR RefSeq; XP_006509343.1; XM_006509280.2. DR RefSeq; XP_006509344.1; XM_006509281.3. DR RefSeq; XP_006509345.1; XM_006509282.3. DR RefSeq; XP_006509346.1; XM_006509283.3. DR UniGene; Mm.33874; -. DR PDB; 3CIG; X-ray; 2.66 A; A=28-704. DR PDB; 3CIY; X-ray; 3.41 A; A/B=28-704. DR PDBsum; 3CIG; -. DR PDBsum; 3CIY; -. DR ProteinModelPortal; Q99MB1; -. DR SMR; Q99MB1; -. DR BioGrid; 228338; 8. DR IntAct; Q99MB1; 1. DR MINT; Q99MB1; -. DR STRING; 10090.ENSMUSP00000034056; -. DR ChEMBL; CHEMBL2146340; -. DR iPTMnet; Q99MB1; -. DR PhosphoSitePlus; Q99MB1; -. DR MaxQB; Q99MB1; -. DR PaxDb; Q99MB1; -. DR PRIDE; Q99MB1; -. DR Ensembl; ENSMUST00000034056; ENSMUSP00000034056; ENSMUSG00000031639. DR Ensembl; ENSMUST00000167106; ENSMUSP00000126556; ENSMUSG00000031639. DR Ensembl; ENSMUST00000209772; ENSMUSP00000147738; ENSMUSG00000031639. DR GeneID; 142980; -. DR KEGG; mmu:142980; -. DR UCSC; uc009loy.1; mouse. DR CTD; 7098; -. DR MGI; MGI:2156367; Tlr3. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000251618; -. DR HOVERGEN; HBG023181; -. DR InParanoid; Q99MB1; -. DR KO; K05401; -. DR OMA; HLLKDPL; -. DR OrthoDB; EOG091G02Q2; -. DR PhylomeDB; Q99MB1; -. DR TreeFam; TF325595; -. DR Reactome; R-MMU-1679131; Trafficking and processing of endosomal TLR. DR EvolutionaryTrace; Q99MB1; -. DR PRO; PR:Q99MB1; -. DR Proteomes; UP000000589; Chromosome 8. DR Bgee; ENSMUSG00000031639; -. DR CleanEx; MM_TLR3; -. DR ExpressionAtlas; Q99MB1; baseline and differential. DR Genevisible; Q99MB1; MM. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0005622; C:intracellular; ISO:MGI. DR GO; GO:0003725; F:double-stranded RNA binding; ISS:UniProtKB. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0004872; F:receptor activity; IBA:GO_Central. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0035690; P:cellular response to drug; IEA:Ensembl. DR GO; GO:0071360; P:cellular response to exogenous dsRNA; IEA:Ensembl. DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:Ensembl. DR GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0006952; P:defense response; IMP:MGI. DR GO; GO:0051607; P:defense response to virus; IGI:MGI. DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:MGI. DR GO; GO:0007252; P:I-kappaB phosphorylation; ISO:MGI. DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; TAS:BHF-UCL. DR GO; GO:0008584; P:male gonad development; IEA:Ensembl. DR GO; GO:0001774; P:microglial cell activation; IEA:Ensembl. DR GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0097527; P:necroptotic signaling pathway; ISO:MGI. DR GO; GO:0045766; P:positive regulation of angiogenesis; IGI:BHF-UCL. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IMP:MGI. DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:MGI. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; ISS:UniProtKB. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; ISS:UniProtKB. DR GO; GO:0032728; P:positive regulation of interferon-beta production; IDA:BHF-UCL. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; ISS:UniProtKB. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IDA:BHF-UCL. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:BHF-UCL. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI. DR GO; GO:0046330; P:positive regulation of JNK cascade; IDA:MGI. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; ISO:MGI. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:MGI. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL. DR GO; GO:0032481; P:positive regulation of type I interferon production; IDA:MGI. DR GO; GO:0034346; P:positive regulation of type III interferon production; IDA:MGI. DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IDA:MGI. DR GO; GO:0043330; P:response to exogenous dsRNA; IMP:MGI. DR GO; GO:0009615; P:response to virus; IMP:MGI. DR GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IEA:InterPro. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027173; TLR3. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44599; PTHR44599; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 16. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Disulfide bond; KW Endoplasmic reticulum; Endosome; Glycoprotein; Immunity; KW Inflammatory response; Innate immunity; Leucine-rich repeat; Membrane; KW Phosphoprotein; Receptor; Reference proteome; Repeat; RNA-binding; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 25 {ECO:0000255}. FT CHAIN 26 905 Toll-like receptor 3. FT /FTId=PRO_0000034716. FT TOPO_DOM 26 705 Lumenal. {ECO:0000255}. FT TRANSMEM 706 726 Helical. {ECO:0000255}. FT TOPO_DOM 727 905 Cytoplasmic. {ECO:0000255}. FT DOMAIN 26 52 LRRNT. FT REPEAT 53 74 LRR 1. FT REPEAT 77 98 LRR 2. FT REPEAT 101 122 LRR 3. FT REPEAT 125 146 LRR 4. FT REPEAT 149 170 LRR 5. FT REPEAT 173 196 LRR 6. FT REPEAT 199 220 LRR 7. FT REPEAT 250 271 LRR 8. FT REPEAT 276 297 LRR 9. FT REPEAT 300 321 LRR 10. FT REPEAT 324 345 LRR 11. FT REPEAT 357 378 LRR 12. FT REPEAT 381 401 LRR 13. FT REPEAT 409 430 LRR 14. FT REPEAT 433 454 LRR 15. FT REPEAT 458 479 LRR 16. FT REPEAT 482 502 LRR 17. FT REPEAT 508 529 LRR 18. FT REPEAT 532 553 LRR 19. FT REPEAT 564 585 LRR 20. FT REPEAT 588 609 LRR 21. FT REPEAT 612 633 LRR 22. FT DOMAIN 646 699 LRRCT. FT DOMAIN 755 897 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT MOD_RES 760 760 Phosphotyrosine. FT {ECO:0000250|UniProtKB:O15455}. FT MOD_RES 859 859 Phosphotyrosine. FT {ECO:0000250|UniProtKB:O15455}. FT CARBOHYD 53 53 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 58 58 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 71 71 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 125 125 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 197 197 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 248 248 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 253 253 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 276 276 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 292 292 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 399 399 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 414 414 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 425 425 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 508 508 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 663 663 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT CARBOHYD 668 668 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:18420935}. FT DISULFID 29 38 {ECO:0000269|PubMed:18420935}. FT DISULFID 96 123 {ECO:0000269|PubMed:18420935}. FT DISULFID 650 678 {ECO:0000269|PubMed:18420935}. FT DISULFID 652 697 {ECO:0000269|PubMed:18420935}. FT CONFLICT 670 670 S -> F (in Ref. 2; AAK26117). FT {ECO:0000305}. FT STRAND 33 37 {ECO:0000244|PDB:3CIY}. FT STRAND 55 58 {ECO:0000244|PDB:3CIY}. FT TURN 69 72 {ECO:0000244|PDB:3CIG}. FT TURN 74 77 {ECO:0000244|PDB:3CIG}. FT STRAND 79 82 {ECO:0000244|PDB:3CIG}. FT HELIX 94 98 {ECO:0000244|PDB:3CIG}. FT STRAND 104 106 {ECO:0000244|PDB:3CIG}. FT HELIX 117 120 {ECO:0000244|PDB:3CIY}. FT STRAND 128 130 {ECO:0000244|PDB:3CIG}. FT TURN 143 146 {ECO:0000244|PDB:3CIG}. FT STRAND 152 154 {ECO:0000244|PDB:3CIG}. FT STRAND 167 169 {ECO:0000244|PDB:3CIG}. FT STRAND 176 178 {ECO:0000244|PDB:3CIG}. FT HELIX 190 195 {ECO:0000244|PDB:3CIG}. FT STRAND 199 204 {ECO:0000244|PDB:3CIG}. FT TURN 215 220 {ECO:0000244|PDB:3CIG}. FT STRAND 221 224 {ECO:0000244|PDB:3CIG}. FT STRAND 226 228 {ECO:0000244|PDB:3CIG}. FT HELIX 236 246 {ECO:0000244|PDB:3CIG}. FT STRAND 247 249 {ECO:0000244|PDB:3CIG}. FT STRAND 253 255 {ECO:0000244|PDB:3CIG}. FT STRAND 262 264 {ECO:0000244|PDB:3CIY}. FT TURN 266 269 {ECO:0000244|PDB:3CIG}. FT HELIX 270 272 {ECO:0000244|PDB:3CIG}. FT STRAND 279 281 {ECO:0000244|PDB:3CIG}. FT TURN 292 297 {ECO:0000244|PDB:3CIG}. FT STRAND 303 305 {ECO:0000244|PDB:3CIG}. FT TURN 316 321 {ECO:0000244|PDB:3CIG}. FT STRAND 327 329 {ECO:0000244|PDB:3CIG}. FT STRAND 339 341 {ECO:0000244|PDB:3CIG}. FT TURN 349 354 {ECO:0000244|PDB:3CIG}. FT STRAND 360 362 {ECO:0000244|PDB:3CIG}. FT TURN 373 378 {ECO:0000244|PDB:3CIY}. FT STRAND 384 386 {ECO:0000244|PDB:3CIG}. FT STRAND 391 393 {ECO:0000244|PDB:3CIG}. FT TURN 399 402 {ECO:0000244|PDB:3CIG}. FT HELIX 403 405 {ECO:0000244|PDB:3CIG}. FT STRAND 412 414 {ECO:0000244|PDB:3CIG}. FT TURN 425 430 {ECO:0000244|PDB:3CIG}. FT STRAND 436 438 {ECO:0000244|PDB:3CIG}. FT STRAND 445 447 {ECO:0000244|PDB:3CIG}. FT HELIX 451 453 {ECO:0000244|PDB:3CIY}. FT STRAND 461 463 {ECO:0000244|PDB:3CIG}. FT STRAND 468 471 {ECO:0000244|PDB:3CIG}. FT TURN 474 479 {ECO:0000244|PDB:3CIG}. FT STRAND 485 487 {ECO:0000244|PDB:3CIG}. FT STRAND 493 495 {ECO:0000244|PDB:3CIG}. FT STRAND 497 500 {ECO:0000244|PDB:3CIY}. FT TURN 502 505 {ECO:0000244|PDB:3CIG}. FT STRAND 511 513 {ECO:0000244|PDB:3CIG}. FT TURN 524 529 {ECO:0000244|PDB:3CIG}. FT STRAND 535 537 {ECO:0000244|PDB:3CIG}. FT STRAND 567 569 {ECO:0000244|PDB:3CIG}. FT TURN 580 585 {ECO:0000244|PDB:3CIG}. FT STRAND 591 593 {ECO:0000244|PDB:3CIG}. FT TURN 604 609 {ECO:0000244|PDB:3CIG}. FT STRAND 615 617 {ECO:0000244|PDB:3CIG}. FT HELIX 628 635 {ECO:0000244|PDB:3CIG}. FT STRAND 639 642 {ECO:0000244|PDB:3CIG}. FT HELIX 652 664 {ECO:0000244|PDB:3CIG}. FT HELIX 672 675 {ECO:0000244|PDB:3CIG}. FT STRAND 677 681 {ECO:0000244|PDB:3CIG}. FT HELIX 682 684 {ECO:0000244|PDB:3CIG}. FT HELIX 689 691 {ECO:0000244|PDB:3CIG}. FT HELIX 694 696 {ECO:0000244|PDB:3CIY}. SQ SEQUENCE 905 AA; 103671 MW; 8EA6DBA9818E14B4 CRC64; MKGCSSYLMY SFGGLLSLWI LLVSSTNQCT VRYNVADCSH LKLTHIPDDL PSNITVLNLT HNQLRRLPPT NFTRYSQLAI LDAGFNSISK LEPELCQILP LLKVLNLQHN ELSQISDQTF VFCTNLTELD LMSNSIHKIK SNPFKNQKNL IKLDLSHNGL SSTKLGTGVQ LENLQELLLA KNKILALRSE ELEFLGNSSL RKLDLSSNPL KEFSPGCFQT IGKLFALLLN NAQLNPHLTE KLCWELSNTS IQNLSLANNQ LLATSESTFS GLKWTNLTQL DLSYNNLHDV GNGSFSYLPS LRYLSLEYNN IQRLSPRSFY GLSNLRYLSL KRAFTKQSVS LASHPNIDDF SFQWLKYLEY LNMDDNNIPS TKSNTFTGLV SLKYLSLSKT FTSLQTLTNE TFVSLAHSPL LTLNLTKNHI SKIANGTFSW LGQLRILDLG LNEIEQKLSG QEWRGLRNIF EIYLSYNKYL QLSTSSFALV PSLQRLMLRR VALKNVDISP SPFRPLRNLT ILDLSNNNIA NINEDLLEGL ENLEILDFQH NNLARLWKRA NPGGPVNFLK GLSHLHILNL ESNGLDEIPV GVFKNLFELK SINLGLNNLN KLEPFIFDDQ TSLRSLNLQK NLITSVEKDV FGPPFQNLNS LDMRFNPFDC TCESISWFVN WINQTHTNIS ELSTHYLCNT PHHYYGFPLK LFDTSSCKDS APFELLFIIS TSMLLVFILV VLLIHIEGWR ISFYWNVSVH RILGFKEIDT QAEQFEYTAY IIHAHKDRDW VWEHFSPMEE QDQSLKFCLE ERDFEAGVLG LEAIVNSIKR SRKIIFVITH HLLKDPLCRR FKVHHAVQQA IEQNLDSIIL IFLQNIPDYK LNHALCLRRG MFKSHCILNW PVQKERINAF HHKLQVALGS RNSAH // ID TLR4_FELCA Reviewed; 833 AA. AC P58727; DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot. DT 11-FEB-2002, sequence version 1. DT 28-FEB-2018, entry version 105. DE RecName: Full=Toll-like receptor 4; DE AltName: CD_antigen=CD284; DE Flags: Precursor; GN Name=TLR4; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Yoshioka N., Kano R.; RT "Felis catus Toll like receptor 4."; RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cooperates with LY96 and CD14 to mediate the innate CC immune response to bacterial lipopolysaccharide (LPS). Acts via CC MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine CC secretion and the inflammatory response. Also involved in LPS- CC independent inflammatory responses triggered by free fatty acids, CC such as palmitate. In complex with TLR6, promotes sterile CC inflammation in monocytes/macrophages in response to oxidized low- CC density lipoprotein (oxLDL) or amyloid-beta 42. In this context, CC the initial signal is provided by oxLDL- or amyloid-beta 42- CC binding to CD36. This event induces the formation of a heterodimer CC of TLR4 and TLR6, which is rapidly internalized and triggers CC inflammatory response, leading to the NF-kappa-B-dependent CC production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling CC pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well CC as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates CC the cytokine release induced by LDL(-) (By similarity). CC {ECO:0000250|UniProtKB:O00206}. CC -!- SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a CC multi-protein complex containing at least CD14, LY96 and TLR4. CC Binding to bacterial LPS leads to homodimerization. Interacts with CC LY96 via the extracellular domain. Interacts with MYD88 and TIRAP CC via their respective TIR domains. Interacts with TICAM2. Interacts CC with NOX4. Interacts with CNPY3 and HSP90B1; this interaction is CC required for proper folding in the endoplasmic reticulum. CC Interacts with MAP3K21; this interaction leads to negative CC regulation of TLR4 signaling. Interacts with CD36, following CD36 CC stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer CC with TLR6. The trimeric complex is internalized and triggers CC inflammatory response. LYN kinase activity facilitates TLR4-TLR6 CC heterodimerization and signal initiation. Interacts with TICAM1 in CC response to LPS in a WDFY1-dependent manner. Interacts with WDFY1 CC in response to LPS. Interacts with SMPDL3B. Interacts with CC CEACAM1; upon lipopolysaccharide stimulation, forms a complex CC including TLR4 and the phosphorylated form of SYK and CEACAM1, CC which in turn, recruits PTPN6 that dephosphorylates SYK, reducing CC the production of reactive oxygen species (ROS) and lysosome CC disruption, which in turn, reduces the activity of the CC inflammasome. Interacts with RFTN1; the interaction occurs in CC response to lipopolysaccharide stimulation. CC {ECO:0000250|UniProtKB:O00206, ECO:0000250|UniProtKB:Q9QUK6}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000250|UniProtKB:O00206}; Single-pass type I membrane CC protein {ECO:0000250|UniProtKB:O00206}. Early endosome CC {ECO:0000250|UniProtKB:O00206}. Note=Upon complex formation with CC CD36 and TLR6, internalized through dynamin-dependent endocytosis. CC Colocalizes with RFTN1 at cell membrane and then together with CC RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. CC {ECO:0000250|UniProtKB:O00206}. CC -!- DOMAIN: The TIR domain mediates interaction with NOX4. CC {ECO:0000250|UniProtKB:O00206}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB060687; BAB43947.1; -; mRNA. DR RefSeq; NP_001009223.1; NM_001009223.1. DR ProteinModelPortal; P58727; -. DR SMR; P58727; -. DR STRING; 9685.ENSFCAP00000023731; -. DR GeneID; 493698; -. DR KEGG; fca:493698; -. DR CTD; 7099; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR HOVERGEN; HBG018823; -. DR InParanoid; P58727; -. DR KO; K10160; -. DR Proteomes; UP000011712; Unplaced. DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; ISS:UniProtKB. DR GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central. DR GO; GO:0001875; F:lipopolysaccharide receptor activity; ISS:UniProtKB. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central. DR GO; GO:0032497; P:detection of lipopolysaccharide; ISS:UniProtKB. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0050702; P:interleukin-1 beta secretion; ISS:UniProtKB. DR GO; GO:0042116; P:macrophage activation; ISS:UniProtKB. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:InterPro. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027168; TLR4. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44568; PTHR44568; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 9. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; Endosome; KW Glycoprotein; Immunity; Inflammatory response; Innate immunity; KW Leucine-rich repeat; Membrane; Receptor; Reference proteome; Repeat; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 23 {ECO:0000255}. FT CHAIN 24 833 Toll-like receptor 4. FT /FTId=PRO_0000034719. FT TOPO_DOM 24 632 Extracellular. {ECO:0000255}. FT TRANSMEM 633 653 Helical. {ECO:0000255}. FT TOPO_DOM 654 833 Cytoplasmic. {ECO:0000255}. FT DOMAIN 24 54 LRRNT. FT REPEAT 55 76 LRR 1. FT REPEAT 79 100 LRR 2. FT REPEAT 103 124 LRR 3. FT REPEAT 127 148 LRR 4. FT REPEAT 151 172 LRR 5. FT REPEAT 176 197 LRR 6. FT REPEAT 205 225 LRR 7. FT REPEAT 227 236 LRR 8. FT REPEAT 352 373 LRR 9. FT REPEAT 374 394 LRR 10. FT REPEAT 400 420 LRR 11. FT REPEAT 423 444 LRR 12. FT REPEAT 448 456 LRR 13. FT REPEAT 472 495 LRR 14. FT REPEAT 497 518 LRR 15. FT REPEAT 521 542 LRR 16. FT REPEAT 545 565 LRR 17. FT DOMAIN 579 630 LRRCT. FT DOMAIN 673 819 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 35 35 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 173 173 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 205 205 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 238 238 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 309 309 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 497 497 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 526 526 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 570 570 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 575 575 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 625 625 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 29 40 {ECO:0000250|UniProtKB:O00206}. FT DISULFID 281 306 {ECO:0000250|UniProtKB:O00206}. FT DISULFID 390 391 {ECO:0000250|UniProtKB:O00206}. FT DISULFID 583 609 {ECO:0000250|UniProtKB:O00206}. FT DISULFID 585 628 {ECO:0000250|UniProtKB:O00206}. SQ SEQUENCE 833 AA; 95592 MW; 3E3A84F2BEBA55EA CRC64; MMPPTRLAGT LIPAMAFLSC LRPESWDPCV EVVPNITYQC MDLNLHKIPD NIPSSTKDLD MSFNPLRNLG SHSFSNFPEL QVLDLSRCEI QIIEDDAYQG LNHLSILILT GNPIQRLFPG AFSGLSSLQT LVAVETNIAS LEDFPIGHLK TLKELNVAHN LIHSFKLPEY FSNMSNLEYL DLSNNKIQNI YHKDLQVLHQ KPLLNLSLDL SLNPLDFIQP GAFKEVKLRE LTLRSNFNST DVMKASIQGL AGLQIHQLVL GEFKNERNLG RFDKSILEGL CNLIIEKFRI AYFDKFSEDA IDSFNCLANV STISLVHLYF KGLKQLPKNL GWQRLELVNC EFEQFPTWKL DPLKELVFSA NEVRNAFTQV KLESLEFLDL SRNDFSLKSC CSERDLGTTR LKHLDLSFNN IITISSNFLG LEQLEYLDFQ HSSLKQVSDF SVFLPLKNLR YLDISYTHTQ VAFHGIFNGL ISLQILKMAG NSFQDNFLPN IFMELTNLTI LDLSDCQLEQ VSQVAFNSLP KLQLLNMSHN HLLSLDTLPY EPLHSLQTLD CSFNRIVASK EQELRHFPSN LSSLNLTRND FACVCEHQSF LQWVKDQRQL LVEVEQMVCA KPLDMQGMPM LNFRNATCQV RKTIITGSVF TVLLVFLVVV LVYKFYFHLM LLAGCKKYSR GESTYDAFVI YSSQDEDWVR NELVKNLEEG VPPFQLCLHY RDFIPGVAIA ANIIQEGFHK SRKVIVVVSQ HFIQSRWCIF EYGIAQTWQF LSSRAGIIFI VLQKLEKSLL RQQVELYRLL NRNTYLEWED SVLGRHIFWR RLRKALLDGK PRCPEGMADA EGS // ID TLR7_HUMAN Reviewed; 1049 AA. AC Q9NYK1; D1CS69; Q9NR98; DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 28-FEB-2018, entry version 168. DE RecName: Full=Toll-like receptor 7; DE Flags: Precursor; GN Name=TLR7; ORFNames=UNQ248/PRO285; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Placenta; RX PubMed=11022119; RA Du X., Poltorak A., Wei Y., Beutler B.; RT "Three novel mammalian Toll-like receptors: gene structure, RT expression, and evolution."; RL Eur. Cytokine Netw. 11:362-371(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Placenta; RX PubMed=11022120; RA Chuang T.-H., Ulevitch R.J.; RT "Cloning and characterization of a sub-family of human Toll-like RT receptors: hTLR7, hTLR8 and hTLR9."; RL Eur. Cytokine Netw. 11:372-378(2000). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-11. RX PubMed=19924287; DOI=10.1371/journal.pone.0007803; RA Georgel P., Macquin C., Bahram S.; RT "The heterogeneous allelic repertoire of human Toll-Like receptor RT (TLR) genes."; RL PLoS ONE 4:E7803-E7803(2009). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP FUNCTION. RX PubMed=18250417; DOI=10.4049/jimmunol.180.4.2117; RA Gantier M.P., Tong S., Behlke M.A., Xu D., Phipps S., Foster P.S., RA Williams B.R.; RT "TLR7 is involved in sequence-specific sensing of single-stranded RNAs RT in human macrophages."; RL J. Immunol. 180:2117-2124(2008). CC -!- FUNCTION: Key component of innate and adaptive immunity. TLRs CC (Toll-like receptors) control host immune response against CC pathogens through recognition of molecular patterns specific to CC microorganisms. TLR7 is a nucleotide-sensing TLR which is CC activated by single-stranded RNA. Acts via MYD88 and TRAF6, CC leading to NF-kappa-B activation, cytokine secretion and the CC inflammatory response (By similarity). {ECO:0000250, CC ECO:0000269|PubMed:18250417}. CC -!- SUBUNIT: Interacts with MYD88 via their respective TIR domains. CC Interacts with UNC93B1. Interacts with SMPDL3B (By similarity). CC {ECO:0000250|UniProtKB:P58681}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000250|UniProtKB:P58681}; Single-pass type I membrane CC protein {ECO:0000250|UniProtKB:P58681}. Endosome CC {ECO:0000250|UniProtKB:P58681}. Lysosome CC {ECO:0000250|UniProtKB:P58681}. Cytoplasmic vesicle, phagosome CC {ECO:0000250|UniProtKB:P58681}. Note=Relocalizes from endoplasmic CC reticulum to endosome and lysosome upon stimulation with agonist. CC {ECO:0000250|UniProtKB:P58681}. CC -!- TISSUE SPECIFICITY: Detected in brain, placenta, spleen, stomach, CC small intestine, lung and in plasmacytoid pre-dendritic cells. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF240467; AAF60188.1; -; mRNA. DR EMBL; AF245702; AAF78035.1; -; mRNA. DR EMBL; DQ022185; AAZ99026.1; -; Genomic_DNA. DR EMBL; AY358292; AAQ88659.1; -; mRNA. DR EMBL; BC033651; AAH33651.1; -; mRNA. DR CCDS; CCDS14151.1; -. DR RefSeq; NP_057646.1; NM_016562.3. DR UniGene; Hs.659215; -. DR ProteinModelPortal; Q9NYK1; -. DR SMR; Q9NYK1; -. DR BioGrid; 119436; 2. DR IntAct; Q9NYK1; 8. DR STRING; 9606.ENSP00000370034; -. DR BindingDB; Q9NYK1; -. DR ChEMBL; CHEMBL5936; -. DR DrugBank; DB05127; ANA971. DR DrugBank; DB01611; Hydroxychloroquine. DR DrugBank; DB00724; Imiquimod. DR DrugBank; DB04860; Isatoribine. DR DrugBank; DB05475; SCV-07. DR GuidetoPHARMACOLOGY; 1757; -. DR iPTMnet; Q9NYK1; -. DR PhosphoSitePlus; Q9NYK1; -. DR BioMuta; TLR7; -. DR DMDM; 20140876; -. DR PaxDb; Q9NYK1; -. DR PeptideAtlas; Q9NYK1; -. DR PRIDE; Q9NYK1; -. DR DNASU; 51284; -. DR Ensembl; ENST00000380659; ENSP00000370034; ENSG00000196664. DR GeneID; 51284; -. DR KEGG; hsa:51284; -. DR UCSC; uc004cvc.4; human. DR CTD; 51284; -. DR DisGeNET; 51284; -. DR EuPathDB; HostDB:ENSG00000196664.4; -. DR GeneCards; TLR7; -. DR HGNC; HGNC:15631; TLR7. DR HPA; HPA059613; -. DR MIM; 300365; gene. DR neXtProt; NX_Q9NYK1; -. DR OpenTargets; ENSG00000196664; -. DR PharmGKB; PA38008; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000230468; -. DR HOVERGEN; HBG018601; -. DR InParanoid; Q9NYK1; -. DR KO; K05404; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR PhylomeDB; Q9NYK1; -. DR TreeFam; TF325595; -. DR Reactome; R-HSA-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-HSA-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-HSA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-HSA-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-HSA-975155; MyD88 dependent cascade initiated on endosome. DR ChiTaRS; TLR7; human. DR GeneWiki; TLR_7; -. DR GenomeRNAi; 51284; -. DR PRO; PR:Q9NYK1; -. DR Proteomes; UP000005640; Chromosome X. DR Bgee; ENSG00000196664; -. DR CleanEx; HS_TLR7; -. DR ExpressionAtlas; Q9NYK1; baseline and differential. DR Genevisible; Q9NYK1; HS. DR GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL. DR GO; GO:0032009; C:early phagosome; ISS:UniProtKB. DR GO; GO:0036020; C:endolysosome membrane; TAS:Reactome. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005768; C:endosome; ISS:UniProtKB. DR GO; GO:0010008; C:endosome membrane; TAS:Reactome. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; ISS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL. DR GO; GO:0043235; C:receptor complex; IDA:MGI. DR GO; GO:0003725; F:double-stranded RNA binding; IDA:UniProtKB. DR GO; GO:0008144; F:drug binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; ISS:UniProtKB. DR GO; GO:0035197; F:siRNA binding; ISS:UniProtKB. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB. DR GO; GO:0051607; P:defense response to virus; IMP:UniProtKB. DR GO; GO:0007252; P:I-kappaB phosphorylation; IDA:BHF-UCL. DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0001774; P:microglial cell activation; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IDA:BHF-UCL. DR GO; GO:0050729; P:positive regulation of inflammatory response; IC:BHF-UCL. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IDA:UniProtKB. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IDA:UniProtKB. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IDA:UniProtKB. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IMP:UniProtKB. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IDA:BHF-UCL. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IDA:BHF-UCL. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IBA:GO_Central. DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome. DR GO; GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; KW Endosome; Glycoprotein; Immunity; Inflammatory response; KW Innate immunity; Leucine-rich repeat; Lysosome; Membrane; KW Polymorphism; Receptor; Reference proteome; Repeat; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 26 {ECO:0000255}. FT CHAIN 27 1049 Toll-like receptor 7. FT /FTId=PRO_0000034733. FT TOPO_DOM 27 839 Extracellular. {ECO:0000255}. FT TRANSMEM 840 860 Helical. {ECO:0000255}. FT TOPO_DOM 861 1049 Cytoplasmic. {ECO:0000255}. FT REPEAT 43 64 LRR 1. FT REPEAT 65 87 LRR 2. FT REPEAT 110 126 LRR 3. FT REPEAT 127 149 LRR 4. FT REPEAT 151 170 LRR 5. FT REPEAT 171 195 LRR 6. FT REPEAT 203 226 LRR 7. FT REPEAT 228 247 LRR 8. FT REPEAT 248 275 LRR 9. FT REPEAT 289 312 LRR 10. FT REPEAT 314 337 LRR 11. FT REPEAT 339 368 LRR 12. FT REPEAT 369 392 LRR 13. FT REPEAT 396 419 LRR 14. FT REPEAT 421 443 LRR 15. FT REPEAT 492 515 LRR 16. FT REPEAT 516 540 LRR 17. FT REPEAT 541 564 LRR 18. FT REPEAT 566 588 LRR 19. FT REPEAT 595 618 LRR 20. FT REPEAT 619 644 LRR 21. FT REPEAT 649 672 LRR 22. FT REPEAT 674 697 LRR 23. FT REPEAT 698 721 LRR 24. FT REPEAT 723 745 LRR 25. FT REPEAT 746 769 LRR 26. FT REPEAT 772 795 LRR 27. FT DOMAIN 889 1036 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 66 66 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 69 69 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 167 167 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 202 202 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 215 215 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 361 361 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 413 413 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 488 488 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 523 523 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 534 534 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 590 590 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 679 679 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 720 720 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 799 799 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT VARIANT 11 11 Q -> L (in dbSNP:rs179008). FT {ECO:0000269|PubMed:19924287}. FT /FTId=VAR_034554. FT VARIANT 448 448 A -> V (in dbSNP:rs5743781). FT /FTId=VAR_024665. FT CONFLICT 725 725 L -> H (in Ref. 2; AAF78035). FT {ECO:0000305}. FT CONFLICT 738 738 L -> P (in Ref. 2; AAF78035). FT {ECO:0000305}. SQ SEQUENCE 1049 AA; 120922 MW; 8C701E9E437F2721 CRC64; MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV // ID TLR8_HUMAN Reviewed; 1041 AA. AC Q9NR97; B3Y654; D1CS70; D1CS76; Q495P4; Q6UXL6; Q9NYG9; DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 28-MAR-2018, entry version 165. DE RecName: Full=Toll-like receptor 8; DE AltName: CD_antigen=CD288; DE Flags: Precursor; GN Name=TLR8; ORFNames=UNQ249/PRO286; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RC TISSUE=Placenta; RX PubMed=11022119; RA Du X., Poltorak A., Wei Y., Beutler B.; RT "Three novel mammalian Toll-like receptors: gene structure, RT expression, and evolution."; RL Eur. Cytokine Netw. 11:362-371(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=11022120; RA Chuang T.-H., Ulevitch R.J.; RT "Cloning and characterization of a sub-family of human Toll-like RT receptors: hTLR7, hTLR8 and hTLR9."; RL Eur. Cytokine Netw. 11:372-378(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=18810425; DOI=10.1007/s00251-008-0332-0; RA Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., RA Kimura A.; RT "Natural selection in the TLR-related genes in the course of primate RT evolution."; RL Immunogenetics 60:727-735(2008). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=19924287; DOI=10.1371/journal.pone.0007803; RA Georgel P., Macquin C., Bahram S.; RT "The heterogeneous allelic repertoire of human Toll-Like receptor RT (TLR) genes."; RL PLoS ONE 4:E7803-E7803(2009). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., RA Williams G., Williams L., Williamson A., Williamson H., Wilming L., RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP FUNCTION, AND INTERACTION WITH BTK. RX PubMed=17932028; DOI=10.1074/jbc.M707682200; RA Doyle S.L., Jefferies C.A., Feighery C., O'Neill L.A.; RT "Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine RT kinase."; RL J. Biol. Chem. 282:36953-36960(2007). RN [10] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-80 AND ASN-88. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of RT multiple enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [11] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 27-827 IN COMPLEXES WITH RP RESIQUIMOD AND OTHER SYNTHETIC AGONISTS, FUNCTION, SUBUNIT, RP LEUCINE-RICH REPEATS, MUTAGENESIS OF TYR-348; VAL-378; PHE-405; RP VAL-520; ASP-543 AND THR-574, GLYCOSYLATION AT ASN-293; ASN-395; RP ASN-511; ASN-546; ASN-590; ASN-640 AND ASN-680, AND DISULFIDE BONDS. RX PubMed=23520111; DOI=10.1126/science.1229159; RA Tanji H., Ohto U., Shibata T., Miyake K., Shimizu T.; RT "Structural reorganization of the Toll-like receptor 8 dimer induced RT by agonistic ligands."; RL Science 339:1426-1429(2013). CC -!- FUNCTION: Key component of innate and adaptive immunity. TLRs CC (Toll-like receptors) control host immune response against CC pathogens through recognition of molecular patterns specific to CC microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B CC activation, cytokine secretion and the inflammatory response. CC {ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23520111}. CC -!- SUBUNIT: Interacts with MYD88 via their respective TIR domains. CC Interacts with UNC93B1 (By similarity). Homodimer. Interacts with CC BTK. Interacts with SMPDL3B (By similarity). CC {ECO:0000250|UniProtKB:P58682, ECO:0000269|PubMed:17932028, CC ECO:0000269|PubMed:23520111}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I CC membrane protein {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9NR97-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9NR97-2; Sequence=VSP_053412; CC -!- TISSUE SPECIFICITY: Detected in brain, heart, lung, liver, CC placenta, in monocytes, and at lower levels in CD11c+ immature CC dendritic cells. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF246971; AAF64061.1; -; mRNA. DR EMBL; AF245703; AAF78036.1; -; mRNA. DR EMBL; AB445666; BAG55063.1; -; mRNA. DR EMBL; DQ023132; AAZ95433.1; -; Genomic_DNA. DR EMBL; DQ023133; AAZ95434.1; -; Genomic_DNA. DR EMBL; DQ023134; AAZ95435.1; -; Genomic_DNA. DR EMBL; DQ023135; AAZ95436.1; -; Genomic_DNA. DR EMBL; DQ023136; AAZ95437.1; -; Genomic_DNA. DR EMBL; DQ023137; AAZ95438.1; -; Genomic_DNA. DR EMBL; DQ023138; AAZ95439.1; -; Genomic_DNA. DR EMBL; DQ023139; AAZ95440.1; -; Genomic_DNA. DR EMBL; DQ023140; AAZ95441.1; -; Genomic_DNA. DR EMBL; CH471074; EAW98808.1; -; Genomic_DNA. DR EMBL; AY358296; AAQ88663.1; -; mRNA. DR EMBL; AC005859; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC139705; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471074; EAW98809.1; -; Genomic_DNA. DR EMBL; BC101076; AAI01077.1; -; mRNA. DR EMBL; BC101077; AAI01078.1; -; mRNA. DR CCDS; CCDS14152.1; -. [Q9NR97-1] DR CCDS; CCDS14153.1; -. [Q9NR97-2] DR RefSeq; NP_057694.2; NM_016610.3. [Q9NR97-2] DR RefSeq; NP_619542.1; NM_138636.5. [Q9NR97-1] DR RefSeq; XP_011543831.1; XM_011545529.1. [Q9NR97-2] DR RefSeq; XP_011543832.1; XM_011545530.2. [Q9NR97-2] DR UniGene; Hs.660543; -. DR PDB; 3W3G; X-ray; 2.30 A; A/B=27-827. DR PDB; 3W3J; X-ray; 2.00 A; A/B=27-827. DR PDB; 3W3K; X-ray; 2.30 A; A/B=27-827. DR PDB; 3W3L; X-ray; 2.33 A; A/B/C/D=27-827. DR PDB; 3W3M; X-ray; 2.70 A; A=27-827. DR PDB; 3W3N; X-ray; 2.10 A; A/B=27-827. DR PDB; 3WN4; X-ray; 1.81 A; A=27-827. DR PDB; 4QBZ; X-ray; 2.00 A; A/B=27-827. DR PDB; 4QC0; X-ray; 2.10 A; A/B=27-827. DR PDB; 4R07; X-ray; 2.00 A; A/B/C/D=27-827. DR PDB; 4R08; X-ray; 2.40 A; A/B/C/D=27-827. DR PDB; 4R09; X-ray; 2.62 A; A/B/C/D=27-827. DR PDB; 4R0A; X-ray; 1.90 A; A=27-827. DR PDB; 4R6A; X-ray; 2.10 A; A/B=27-827. DR PDB; 5AWA; X-ray; 2.20 A; A=27-827. DR PDB; 5AWB; X-ray; 2.10 A; A=27-827. DR PDB; 5AWC; X-ray; 2.50 A; A/B/C/D=27-827. DR PDB; 5AWD; X-ray; 2.05 A; A=27-827. DR PDB; 5AZ5; X-ray; 2.40 A; A/B/C/D=27-827. DR PDB; 5HDH; X-ray; 2.60 A; A=27-827. DR PDB; 5WYX; X-ray; 2.40 A; A/B=27-827. DR PDB; 5WYZ; X-ray; 2.30 A; A/B=27-827. DR PDBsum; 3W3G; -. DR PDBsum; 3W3J; -. DR PDBsum; 3W3K; -. DR PDBsum; 3W3L; -. DR PDBsum; 3W3M; -. DR PDBsum; 3W3N; -. DR PDBsum; 3WN4; -. DR PDBsum; 4QBZ; -. DR PDBsum; 4QC0; -. DR PDBsum; 4R07; -. DR PDBsum; 4R08; -. DR PDBsum; 4R09; -. DR PDBsum; 4R0A; -. DR PDBsum; 4R6A; -. DR PDBsum; 5AWA; -. DR PDBsum; 5AWB; -. DR PDBsum; 5AWC; -. DR PDBsum; 5AWD; -. DR PDBsum; 5AZ5; -. DR PDBsum; 5HDH; -. DR PDBsum; 5WYX; -. DR PDBsum; 5WYZ; -. DR ProteinModelPortal; Q9NR97; -. DR SMR; Q9NR97; -. DR BioGrid; 119462; 1. DR DIP; DIP-61413N; -. DR IntAct; Q9NR97; 1. DR STRING; 9606.ENSP00000218032; -. DR BindingDB; Q9NR97; -. DR ChEMBL; CHEMBL5805; -. DR DrugBank; DB00724; Imiquimod. DR GuidetoPHARMACOLOGY; 1758; -. DR iPTMnet; Q9NR97; -. DR PhosphoSitePlus; Q9NR97; -. DR BioMuta; TLR8; -. DR DMDM; 20140873; -. DR PaxDb; Q9NR97; -. DR PeptideAtlas; Q9NR97; -. DR PRIDE; Q9NR97; -. DR Ensembl; ENST00000218032; ENSP00000218032; ENSG00000101916. [Q9NR97-1] DR Ensembl; ENST00000311912; ENSP00000312082; ENSG00000101916. [Q9NR97-2] DR GeneID; 51311; -. DR KEGG; hsa:51311; -. DR UCSC; uc004cvd.4; human. [Q9NR97-1] DR CTD; 51311; -. DR DisGeNET; 51311; -. DR EuPathDB; HostDB:ENSG00000101916.11; -. DR GeneCards; TLR8; -. DR H-InvDB; HIX0176772; -. DR HGNC; HGNC:15632; TLR8. DR HPA; HPA001608; -. DR MIM; 300366; gene. DR neXtProt; NX_Q9NR97; -. DR OpenTargets; ENSG00000101916; -. DR PharmGKB; PA38009; -. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000119006; -. DR HOGENOM; HOG000230468; -. DR HOVERGEN; HBG018601; -. DR InParanoid; Q9NR97; -. DR KO; K10170; -. DR OMA; WPDNPKA; -. DR OrthoDB; EOG091G014D; -. DR PhylomeDB; Q9NR97; -. DR TreeFam; TF351113; -. DR Reactome; R-HSA-1679131; Trafficking and processing of endosomal TLR. DR Reactome; R-HSA-168181; Toll Like Receptor 7/8 (TLR7/8) Cascade. DR Reactome; R-HSA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling. DR Reactome; R-HSA-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-HSA-975155; MyD88 dependent cascade initiated on endosome. DR GeneWiki; TLR8; -. DR GenomeRNAi; 51311; -. DR PRO; PR:Q9NR97; -. DR Proteomes; UP000005640; Chromosome X. DR Bgee; ENSG00000101916; -. DR CleanEx; HS_TLR8; -. DR Genevisible; Q9NR97; HS. DR GO; GO:0036020; C:endolysosome membrane; TAS:Reactome. DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0010008; C:endosome membrane; TAS:Reactome. DR GO; GO:0009897; C:external side of plasma membrane; IDA:CAFA. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB. DR GO; GO:0003725; F:double-stranded RNA binding; IDA:UniProtKB. DR GO; GO:0008144; F:drug binding; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0004872; F:receptor activity; IBA:GO_Central. DR GO; GO:0003723; F:RNA binding; TAS:UniProtKB. DR GO; GO:0003727; F:single-stranded RNA binding; IDA:UniProtKB. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB. DR GO; GO:0051607; P:defense response to virus; IMP:UniProtKB. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IDA:UniProtKB. DR GO; GO:0016064; P:immunoglobulin mediated immune response; TAS:UniProtKB. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; NAS:UniProtKB. DR GO; GO:0001774; P:microglial cell activation; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IDA:CAFA. DR GO; GO:0045089; P:positive regulation of innate immune response; IDA:UniProtKB. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IDA:UniProtKB. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IDA:UniProtKB. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IDA:UniProtKB. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IDA:CAFA. DR GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:CAFA. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IMP:UniProtKB. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0009615; P:response to virus; IDA:UniProtKB. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IDA:CAFA. DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome. DR GO; GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 15. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; KW Glycoprotein; Immunity; Inflammatory response; Innate immunity; KW Leucine-rich repeat; Membrane; Polymorphism; Receptor; KW Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 26 {ECO:0000255}. FT CHAIN 27 1041 Toll-like receptor 8. FT /FTId=PRO_0000034735. FT TOPO_DOM 27 827 Extracellular. {ECO:0000255}. FT TRANSMEM 828 848 Helical. {ECO:0000255}. FT TOPO_DOM 849 1041 Cytoplasmic. {ECO:0000255}. FT REPEAT 126 147 LRR 1. {ECO:0000269|PubMed:23520111}. FT REPEAT 148 168 LRR 2. {ECO:0000269|PubMed:23520111}. FT REPEAT 171 193 LRR 3. {ECO:0000269|PubMed:23520111}. FT REPEAT 202 223 LRR 4. {ECO:0000269|PubMed:23520111}. FT REPEAT 224 244 LRR 5. {ECO:0000269|PubMed:23520111}. FT REPEAT 247 268 LRR 6. {ECO:0000269|PubMed:23520111}. FT REPEAT 288 309 LRR 7. {ECO:0000269|PubMed:23520111}. FT REPEAT 312 334 LRR 8. {ECO:0000269|PubMed:23520111}. FT REPEAT 338 360 LRR 9. {ECO:0000269|PubMed:23520111}. FT REPEAT 368 389 LRR 10. {ECO:0000269|PubMed:23520111}. FT REPEAT 395 416 LRR 11. {ECO:0000269|PubMed:23520111}. FT REPEAT 419 440 LRR 12. {ECO:0000269|PubMed:23520111}. FT REPEAT 482 503 LRR 13. {ECO:0000269|PubMed:23520111}. FT REPEAT 506 527 LRR 14. {ECO:0000269|PubMed:23520111}. FT REPEAT 531 551 LRR 15. {ECO:0000269|PubMed:23520111}. FT REPEAT 555 577 LRR 16. {ECO:0000269|PubMed:23520111}. FT REPEAT 585 606 LRR 17. {ECO:0000269|PubMed:23520111}. FT REPEAT 609 630 LRR 18. {ECO:0000269|PubMed:23520111}. FT REPEAT 640 661 LRR 19. {ECO:0000269|PubMed:23520111}. FT REPEAT 665 685 LRR 20. {ECO:0000269|PubMed:23520111}. FT REPEAT 689 710 LRR 21. {ECO:0000269|PubMed:23520111}. FT REPEAT 713 734 LRR 22. {ECO:0000269|PubMed:23520111}. FT REPEAT 737 758 LRR 23. {ECO:0000269|PubMed:23520111}. FT DOMAIN 772 824 LRRCT. FT DOMAIN 878 1025 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 29 29 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 42 42 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 80 80 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT CARBOHYD 88 88 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:19159218}. FT CARBOHYD 115 115 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 160 160 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 247 247 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 285 285 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 293 293 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:23520111}. FT CARBOHYD 358 358 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 362 362 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 395 395 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:23520111}. FT CARBOHYD 416 416 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 443 443 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 511 511 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:23520111}. FT CARBOHYD 546 546 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:23520111}. FT CARBOHYD 582 582 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 590 590 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:23520111}. FT CARBOHYD 640 640 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:23520111}. FT CARBOHYD 680 680 N-linked (GlcNAc...) asparagine. FT {ECO:0000269|PubMed:23520111}. FT CARBOHYD 752 752 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 36 49 {ECO:0000269|PubMed:23520111}. FT DISULFID 181 187 {ECO:0000269|PubMed:23520111}. FT DISULFID 257 270 {ECO:0000269|PubMed:23520111}. FT DISULFID 260 267 {ECO:0000269|PubMed:23520111}. FT DISULFID 479 509 {ECO:0000269|PubMed:23520111}. FT DISULFID 776 803 {ECO:0000269|PubMed:23520111}. FT VAR_SEQ 1 1 M -> MKESSLQNSSCSLGKETKK (in isoform 2). FT {ECO:0000303|PubMed:11022119}. FT /FTId=VSP_053412. FT VARIANT 10 10 M -> V (in dbSNP:rs5744077). FT /FTId=VAR_024667. FT VARIANT 715 715 R -> Q (in dbSNP:rs5744082). FT /FTId=VAR_052363. FT MUTAGEN 348 348 Y->A: Abolishes activation of NF-kappa-B. FT {ECO:0000269|PubMed:23520111}. FT MUTAGEN 378 378 V->A: Increases activation of NF-kappa-B. FT {ECO:0000269|PubMed:23520111}. FT MUTAGEN 405 405 F->A: Abolishes activation of NF-kappa-B. FT {ECO:0000269|PubMed:23520111}. FT MUTAGEN 520 520 V->A: Strongly decreases activation of FT NF-kappa-B. FT {ECO:0000269|PubMed:23520111}. FT MUTAGEN 543 543 D->A: Abolishes activation of NF-kappa-B. FT {ECO:0000269|PubMed:23520111}. FT MUTAGEN 574 574 T->A: Strongly decreases activation of FT NF-kappa-B. FT {ECO:0000269|PubMed:23520111}. FT CONFLICT 217 217 P -> S (in Ref. 1; AAF64061). FT {ECO:0000305}. FT CONFLICT 328 328 A -> V (in Ref. 5; AAQ88663). FT {ECO:0000305}. FT CONFLICT 366 366 L -> P (in Ref. 1; AAF64061). FT {ECO:0000305}. FT CONFLICT 410 410 D -> N (in Ref. 4; AAZ95439). FT {ECO:0000305}. FT CONFLICT 867 867 V -> I (in Ref. 1; AAF64061). FT {ECO:0000305}. FT STRAND 37 39 {ECO:0000244|PDB:3WN4}. FT STRAND 42 44 {ECO:0000244|PDB:4R0A}. FT STRAND 46 48 {ECO:0000244|PDB:3WN4}. FT STRAND 66 69 {ECO:0000244|PDB:3WN4}. FT TURN 80 85 {ECO:0000244|PDB:3WN4}. FT STRAND 91 93 {ECO:0000244|PDB:3WN4}. FT STRAND 96 98 {ECO:0000244|PDB:3W3J}. FT TURN 118 123 {ECO:0000244|PDB:3WN4}. FT STRAND 129 131 {ECO:0000244|PDB:3WN4}. FT STRAND 149 152 {ECO:0000244|PDB:3WN4}. FT HELIX 163 166 {ECO:0000244|PDB:3WN4}. FT STRAND 174 176 {ECO:0000244|PDB:3WN4}. FT STRAND 179 181 {ECO:0000244|PDB:3WN4}. FT STRAND 183 185 {ECO:0000244|PDB:5WYX}. FT TURN 194 199 {ECO:0000244|PDB:3WN4}. FT STRAND 205 207 {ECO:0000244|PDB:3WN4}. FT STRAND 225 228 {ECO:0000244|PDB:3WN4}. FT TURN 241 244 {ECO:0000244|PDB:3WN4}. FT STRAND 250 252 {ECO:0000244|PDB:3WN4}. FT HELIX 271 273 {ECO:0000244|PDB:3WN4}. FT TURN 280 285 {ECO:0000244|PDB:3WN4}. FT STRAND 291 293 {ECO:0000244|PDB:3WN4}. FT HELIX 304 307 {ECO:0000244|PDB:3WN4}. FT STRAND 315 317 {ECO:0000244|PDB:3WN4}. FT STRAND 320 322 {ECO:0000244|PDB:3W3K}. FT HELIX 324 329 {ECO:0000244|PDB:3WN4}. FT HELIX 331 335 {ECO:0000244|PDB:3WN4}. FT STRAND 341 343 {ECO:0000244|PDB:3WN4}. FT HELIX 361 365 {ECO:0000244|PDB:3WN4}. FT STRAND 371 373 {ECO:0000244|PDB:3WN4}. FT STRAND 380 382 {ECO:0000244|PDB:3WN4}. FT HELIX 384 390 {ECO:0000244|PDB:3WN4}. FT STRAND 398 400 {ECO:0000244|PDB:3WN4}. FT HELIX 411 416 {ECO:0000244|PDB:3WN4}. FT STRAND 417 419 {ECO:0000244|PDB:3W3N}. FT STRAND 421 424 {ECO:0000244|PDB:3WN4}. FT STRAND 459 461 {ECO:0000244|PDB:4R07}. FT STRAND 467 469 {ECO:0000244|PDB:3WN4}. FT HELIX 477 480 {ECO:0000244|PDB:3WN4}. FT STRAND 485 487 {ECO:0000244|PDB:3WN4}. FT TURN 498 503 {ECO:0000244|PDB:3WN4}. FT STRAND 508 511 {ECO:0000244|PDB:3WN4}. FT TURN 525 528 {ECO:0000244|PDB:3WN4}. FT STRAND 533 536 {ECO:0000244|PDB:3WN4}. FT TURN 547 552 {ECO:0000244|PDB:3WN4}. FT STRAND 558 560 {ECO:0000244|PDB:3WN4}. FT HELIX 565 568 {ECO:0000244|PDB:3WN4}. FT TURN 571 573 {ECO:0000244|PDB:3W3G}. FT HELIX 578 582 {ECO:0000244|PDB:3WN4}. FT STRAND 588 590 {ECO:0000244|PDB:3WN4}. FT STRAND 599 601 {ECO:0000244|PDB:5WYZ}. FT STRAND 607 609 {ECO:0000244|PDB:3WN4}. FT STRAND 612 614 {ECO:0000244|PDB:3WN4}. FT HELIX 620 623 {ECO:0000244|PDB:3WN4}. FT STRAND 626 629 {ECO:0000244|PDB:5HDH}. FT TURN 630 637 {ECO:0000244|PDB:3WN4}. FT STRAND 638 640 {ECO:0000244|PDB:3W3M}. FT STRAND 643 645 {ECO:0000244|PDB:3WN4}. FT HELIX 656 660 {ECO:0000244|PDB:3WN4}. FT STRAND 667 670 {ECO:0000244|PDB:3WN4}. FT HELIX 681 686 {ECO:0000244|PDB:3WN4}. FT STRAND 692 694 {ECO:0000244|PDB:3WN4}. FT HELIX 707 709 {ECO:0000244|PDB:3WN4}. FT STRAND 716 718 {ECO:0000244|PDB:3WN4}. FT TURN 729 733 {ECO:0000244|PDB:3WN4}. FT STRAND 734 737 {ECO:0000244|PDB:5AZ5}. FT STRAND 740 742 {ECO:0000244|PDB:3WN4}. FT HELIX 753 756 {ECO:0000244|PDB:3WN4}. FT STRAND 758 760 {ECO:0000244|PDB:3WN4}. FT STRAND 765 768 {ECO:0000244|PDB:3WN4}. FT HELIX 778 780 {ECO:0000244|PDB:3WN4}. FT HELIX 781 789 {ECO:0000244|PDB:3WN4}. FT TURN 790 792 {ECO:0000244|PDB:4R0A}. FT HELIX 798 800 {ECO:0000244|PDB:3WN4}. FT STRAND 801 806 {ECO:0000244|PDB:3WN4}. FT TURN 807 811 {ECO:0000244|PDB:3WN4}. FT HELIX 814 816 {ECO:0000244|PDB:4QBZ}. FT HELIX 819 822 {ECO:0000244|PDB:5HDH}. SQ SEQUENCE 1041 AA; 119828 MW; 39A38B60629291C8 CRC64; MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS NRRLQEVPQT VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV QHQNGNPGIQ SNGLNITDGA FLNLKNLREL LLEDNQLPQI PSGLPESLTE LSLIQNNIYN ITKEGISRLI NLKNLYLAWN CYFNKVCEKT NIEDGVFETL TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE DFKGLINLTL LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK GSYPQHINIS RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN LGINFIKQID FKLFQNFSNL EIIYLSENRI SPLVKDTRQS YANSSSFQRH IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA AYGKALDLSL NSIFFIGPNQ FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN RLDFDNASAL TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR LKHIPNEAFL NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL LFLTDSLSDF TSSLRTLLLS HNRISHLPSG FLSEVSSLKH LDLSSNLLKT INKSALETKT TTKLSMLELH GNPFECTCDI GDFRRWMDEH LNVKIPRLVD VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT MVMLAALAHH LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYISYDTKD ASVTDWVINE LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY AKSWNFKTAF YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQTLRN VVLTENDSRY NNMYVDSIKQ Y // ID TOLL6_DROME Reviewed; 1514 AA. AC Q9VUN0; Q6NN49; Q9NBK9; DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 28-MAR-2018, entry version 147. DE RecName: Full=Toll-like receptor 6 {ECO:0000305}; DE Flags: Precursor; GN Name=Toll-6 {ECO:0000312|FlyBase:FBgn0036494}; GN Synonyms=Tl-6 {ECO:0000312|FlyBase:FBgn0036494}; GN ORFNames=CG7250 {ECO:0000312|FlyBase:FBgn0036494}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803}; RN [1] {ECO:0000312|EMBL:AAF86226.1} RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=10973475; DOI=10.1073/pnas.180130797; RA Tauszig S., Jouanguy E., Hoffmann J.A., Imler J.L.; RT "Toll-related receptors and the control of antimicrobial peptide RT expression in Drosophila."; RL Proc. Natl. Acad. Sci. U.S.A. 97:10520-10525(2000). RN [2] {ECO:0000312|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000312|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000312|EMBL:AAR99103.1, ECO:0000312|EMBL:ACM16686.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley {ECO:0000312|EMBL:AAR99103.1, RC ECO:0000312|EMBL:ACM16686.1}; RC TISSUE=Embryo {ECO:0000312|EMBL:AAR99103.1}; RA Carlson J., Booth B., Chavez C., Frise E., George R., Pacleb J., RA Park S., Rubin G.M., Stapleton M., Wan K., Yu C., Celniker S.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000305} RP DEVELOPMENTAL STAGE. RX PubMed=12617819; DOI=10.1016/S1567-133X(02)00020-0; RA Kambris Z., Hoffmann J.A., Imler J.L., Capovilla M.; RT "Tissue and stage-specific expression of the Tolls in Drosophila RT embryos."; RL Gene Expr. Patterns 2:311-317(2002). RN [6] {ECO:0000305} RP DISRUPTION PHENOTYPE. RX PubMed=21158756; DOI=10.1111/j.1440-169X.2010.01213.x; RA Yagi Y., Nishida Y., Ip Y.T.; RT "Functional analysis of Toll-related genes in Drosophila."; RL Dev. Growth Differ. 52:771-783(2010). RN [7] {ECO:0000305} RP FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=23892553; DOI=10.1038/nn.3474; RA McIlroy G., Foldi I., Aurikko J., Wentzell J.S., Lim M.A., RA Fenton J.C., Gay N.J., Hidalgo A.; RT "Toll-6 and Toll-7 function as neurotrophin receptors in the RT Drosophila melanogaster CNS."; RL Nat. Neurosci. 16:1248-1256(2013). RN [8] {ECO:0000305} RP FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=25363762; DOI=10.1038/nature13953; RA Pare A.C., Vichas A., Fincher C.T., Mirman Z., Farrell D.L., RA Mainieri A., Zallen J.A.; RT "A positional Toll receptor code directs convergent extension in RT Drosophila."; RL Nature 515:523-527(2014). RN [9] {ECO:0000305} RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE. RX PubMed=25741726; DOI=10.1016/j.neuron.2015.02.003; RA Ward A., Hong W., Favaloro V., Luo L.; RT "Toll receptors instruct axon and dendrite targeting and participate RT in synaptic partner matching in a Drosophila olfactory circuit."; RL Neuron 85:1013-1028(2015). CC -!- FUNCTION: Toll-related receptor which binds to the neurotrophin CC spz5 (PubMed:10973475, PubMed:23892553). Functions in olfactory CC circuit assembly by promoting synaptic partner matching between CC olfactory receptor neurons (ORN) axons and projection neurons (PN) CC dendrites partners in the antennal lobe (PubMed:25741726). CC Involved in the targeting of specific classes of PN dendrites CC (Va1d, Va1v, DC3 and DA1) (PubMed:25741726). Functions with Toll-7 CC to regulate motor axon targeting and neuronal survival in the CC central nervous system (CNS) (PubMed:23892553). Possibly functions CC with 18w and Toll-8 during convergent extension, to help direct CC proper planar cell polarity, cell intercalation and axis CC elongation (PubMed:25363762). Promotes heterophilic cell adhesion CC with 18w in vitro (PubMed:25363762). May be an upstream component CC of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553). CC {ECO:0000269|PubMed:10973475, ECO:0000269|PubMed:23892553, CC ECO:0000269|PubMed:25363762, ECO:0000269|PubMed:25741726}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass CC type I membrane protein {ECO:0000305}. CC -!- DEVELOPMENTAL STAGE: Expressed 48 hours after puparium formation CC in lateral glomeruli in the anterior and central regions of the CC antennal lobe, including the DA1, VA1d, VA1v, DC3. DC1, DA4l and CC DA4m glomeruli (at protein level) (PubMed:25741726). Expressed CC zygotically (PubMed:12617819). High levels of expression in CC embryos and pupae, and relatively low levels of expression in CC larvae and adults (PubMed:10973475). At cellular blastoderm stage, CC expressed as several segmentally separated stripes, with the CC anterior stripes appearing first (PubMed:12617819). At germ band CC extension, strongly expressed in the delaminating neuroblasts CC (PubMed:12617819). Expression decreases at germ band extension, CC remaining in a specific subset of neurons in the central nervous CC system (PubMed:12617819). Expressed in 6 segmentally repeated CC stripes in the germband (PubMed:25363762). In larvae, detected in CC the fat body (PubMed:12617819). In larvae, expressed in the optic CC lobes and the ventral nerve cord of the CNS (PubMed:23892553). CC Expressed 48 hours after puparium formation in ORN axons and PN CC dendrites that target to largely overlaping glomeruli CC (PubMed:25741726). {ECO:0000269|PubMed:10973475, CC ECO:0000269|PubMed:12617819, ECO:0000269|PubMed:23892553, CC ECO:0000269|PubMed:25363762, ECO:0000269|PubMed:25741726}. CC -!- DISRUPTION PHENOTYPE: Viable (PubMed:25741726). Dorsomedial or CC dorsolateral mistargeting of VA1d ORN axons (PubMed:25741726). No CC effect on the immune response to septic injury using a mixture of CC Gram-positive and Gram-negative bacteria; adult flies are able CC induce expression of antibacterial peptide genes (Drs, AttA, DptA CC and Mtk) and mount a proper innate immune response CC (PubMed:21158756). {ECO:0000269|PubMed:21158756, CC ECO:0000269|PubMed:25741726}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF247766; AAF86226.1; -; mRNA. DR EMBL; AE014296; AAF49645.1; -; Genomic_DNA. DR EMBL; AE014296; AFH04436.1; -; Genomic_DNA. DR EMBL; AE014296; AFH04437.1; -; Genomic_DNA. DR EMBL; BT011445; AAR99103.1; -; mRNA. DR EMBL; BT057976; ACM16686.1; -; mRNA. DR RefSeq; NP_001246765.1; NM_001259836.2. DR RefSeq; NP_001246766.1; NM_001259837.3. DR RefSeq; NP_524081.1; NM_079357.4. DR UniGene; Dm.2661; -. DR ProteinModelPortal; Q9VUN0; -. DR IntAct; Q9VUN0; 5. DR STRING; 7227.FBpp0297411; -. DR PaxDb; Q9VUN0; -. DR PRIDE; Q9VUN0; -. DR EnsemblMetazoa; FBtr0075614; FBpp0075367; FBgn0036494. DR EnsemblMetazoa; FBtr0306307; FBpp0297410; FBgn0036494. DR EnsemblMetazoa; FBtr0306308; FBpp0297411; FBgn0036494. DR GeneID; 39663; -. DR KEGG; dme:Dmel_CG7250; -. DR UCSC; CG7250-RA; d. melanogaster. DR CTD; 39663; -. DR FlyBase; FBgn0036494; Toll-6. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000118777; -. DR OMA; PDAFRNC; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; Q9VUN0; -. DR GenomeRNAi; 39663; -. DR PRO; PR:Q9VUN0; -. DR Proteomes; UP000000803; Chromosome 3L. DR Bgee; FBgn0036494; -. DR ExpressionAtlas; Q9VUN0; differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005030; F:neurotrophin receptor activity; IMP:FlyBase. DR GO; GO:0003401; P:axis elongation; IGI:FlyBase. DR GO; GO:0060026; P:convergent extension; IGI:FlyBase. DR GO; GO:0070983; P:dendrite guidance; IMP:FlyBase. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 6. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 23. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 24. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Developmental protein; KW Disulfide bond; Glycoprotein; Leucine-rich repeat; Membrane; Receptor; KW Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 14 {ECO:0000255}. FT CHAIN 15 1514 Toll-like receptor 6. FT /FTId=PRO_0000436858. FT TOPO_DOM 15 1057 Extracellular. {ECO:0000305}. FT TRANSMEM 1058 1078 Helical. {ECO:0000255}. FT TOPO_DOM 1079 1514 Cytoplasmic. {ECO:0000305}. FT REPEAT 145 168 LRR 1. {ECO:0000255}. FT REPEAT 170 191 LRR 2. {ECO:0000255}. FT REPEAT 199 222 LRR 3. {ECO:0000255}. FT REPEAT 224 246 LRR 4. {ECO:0000255}. FT REPEAT 276 299 LRR 5. {ECO:0000255}. FT REPEAT 300 323 LRR 6. {ECO:0000255}. FT REPEAT 324 347 LRR 7. {ECO:0000255}. FT REPEAT 349 372 LRR 8. {ECO:0000255}. FT REPEAT 374 398 LRR 9. {ECO:0000255}. FT REPEAT 399 422 LRR 10. {ECO:0000255}. FT REPEAT 424 446 LRR 11. {ECO:0000255}. FT REPEAT 448 470 LRR 12. {ECO:0000255}. FT REPEAT 471 494 LRR 13. {ECO:0000255}. FT REPEAT 495 518 LRR 14. {ECO:0000255}. FT REPEAT 519 541 LRR 15. {ECO:0000255}. FT REPEAT 543 565 LRR 16. {ECO:0000255}. FT REPEAT 566 589 LRR 17. {ECO:0000255}. FT REPEAT 591 612 LRR 18. {ECO:0000255}. FT REPEAT 614 635 LRR 19. {ECO:0000255}. FT REPEAT 636 658 LRR 20. {ECO:0000255}. FT REPEAT 660 682 LRR 21. {ECO:0000255}. FT REPEAT 683 705 LRR 22. {ECO:0000255}. FT REPEAT 707 729 LRR 23. {ECO:0000255}. FT REPEAT 858 881 LRR 24. {ECO:0000255}. FT REPEAT 883 905 LRR 25. {ECO:0000255}. FT REPEAT 906 929 LRR 26. {ECO:0000255}. FT REPEAT 930 953 LRR 27. {ECO:0000255}. FT REPEAT 955 977 LRR 28. {ECO:0000255}. FT DOMAIN 1111 1247 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 111 111 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 174 174 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 230 230 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 253 253 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 331 331 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 359 359 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 406 406 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 494 494 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 557 557 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 620 620 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 708 708 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 829 829 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 891 891 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 900 900 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 948 948 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 1024 1024 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 1033 1033 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT DISULFID 752 802 {ECO:0000250|UniProtKB:P08953}. FT DISULFID 826 832 {ECO:0000250|UniProtKB:P08953}. FT DISULFID 830 845 {ECO:0000250|UniProtKB:P08953}. FT DISULFID 993 1020 {ECO:0000250|UniProtKB:P08953}. FT CONFLICT 249 249 K -> Q (in Ref. 1; AAF86226). FT {ECO:0000305}. FT CONFLICT 889 889 Y -> C (in Ref. 4; AAR99103). FT {ECO:0000305}. FT CONFLICT 1475 1475 V -> A (in Ref. 1; AAF86226). FT {ECO:0000305}. SQ SEQUENCE 1514 AA; 170158 MW; 5BC45E5EE9A1E28F CRC64; MIYYMLLILP VVLAQDQQHT TESLSTKHHQ QQQLSHSNAI MGEAGVSNSQ LMQPSTPART LRPLTAGAGG DPSLYDAPDD CHFMPAAGLD QPEIALTCNL RTVNSEFDTT NFSVIPAEHT IALHILCNDE IMAKSRLEAQ SFAHLVRLQQ LSIQYCKLGR LGRQVLDGLE QLRNLTLRTH NILWPALNFE IEADAFSVTR RLERLDLSSN NIWSLPDNIF CTLSELSALN MSENRLQDVN ELGFRDRSKE PTNGSTESTS TTESAKKSSS SSTSCSLDLE YLDVSHNDFV VLPANGFGTL RRLRVLSVNN NGISMIADKA LSGLKNLQIL NLSSNKIVAL PTELFAEQAK IIQEVYLQNN SISVLNPQLF SNLDQLQALD LSMNQITSTW IDKNTFVGLI RLVLLNLSHN KLTKLEPEIF SDLYTLQILN LRHNQLENIA ADTFAPMNNL HTLLLSHNKL KYLDAYALNG LYVLSLLSLD NNALIGVHPD AFRNCSALQD LNLNGNQLKT VPLALRNMRH LRTVDLGENM ITVMEDSAFK GLGNLYGLRL IGNYLENITM HTFRDLPNLQ ILNLARNRIA VVEPGAFEMT SSIQAVRLDG NELNDINGLF SNMPSLLWLN ISDNRLESFD YGHVPSTLQW LDLHKNRLSS LSNRFGLDSE LKLQTLDVSF NQLQRIGPSS IPNSIELLFL NDNLITTVDP DTFMHKTNLT RVDLYANQIT TLDIKSLRIL PVWEHRALPE FYIGGNPFTC DCNIDWLQKI NHITSRQYPR IMDLETIYCK LLNNRERAYI PLIEAEPKHF LCTYKTHCFA VCHCCEFDAC DCEMTCPTNC TCFHDQTWST NIVECSGAAY SEMPRRVPMD TSELYIDGNN FVELAGHSFL GRKNLAVLYA NNSNVAHIYN TTFSGLKRLL ILHLEDNHII SLEGNEFHNL ENLRELYLQS NKIASIANGS FQMLRKLEVL RLDGNRLMHF EVWQLSANPY LVEISLADNQ WSCECGYLAR FRNYLGQSSE KIIDASRVSC IYNNATSVLR EKNGTKCTLR DGVAHYMHTN EIEGLLPLLL VATCAFVAFF GLIFGLFCYR HELKIWAHST NCLMNFCYKS PRFVDQLDKE RPNDAYFAYS LQDEHFVNQI LAQTLENDIG YRLCLHYRDV NINAYITDAL IEAAESAKQF VLVLSKNFLY NEWSRFEYKS ALHELVKRRK RVVFILYGDL PQRDIDMDMR HYLRTSTCIE WDDKKFWQKL RLALPLPNGR GNNNKRVVSG CLSGRTPSVN MYATSHEYQA GNGGVIPPPS ARYADCGSNN YATINECAAA GGGRGYKPIP TSASAAAAAC KFNTMNQLSK KQQRDLSVAG MAKTLEHQHH HNHQANRRSQ HEYAVPSYLP SAAPAYDSVD YAKQQIRNNA NCECVNLGTA KRAAGKNPAS GLPSSFSSNF VPPGGASYNC KKSCSCIGDD ELLCSCGGGG GIGVNLLESG TQSSVTMSSS SNNSRQPELT HYESNLSLND DEDEDHDQQK NLWA // ID TOLL7_DROME Reviewed; 1446 AA. AC Q7KIN0; E1NZA7; Q2XXU8; DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot. DT 03-OCT-2006, sequence version 1. DT 28-MAR-2018, entry version 121. DE RecName: Full=Toll-like receptor 7 {ECO:0000305}; DE Flags: Precursor; GN Name=Toll-7 {ECO:0000312|FlyBase:FBgn0034476}; GN ORFNames=CG8595 {ECO:0000312|FlyBase:FBgn0034476}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803}; RN [1] {ECO:0000312|EMBL:AAF86225.1} RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=10973475; DOI=10.1073/pnas.180130797; RA Tauszig S., Jouanguy E., Hoffmann J.A., Imler J.L.; RT "Toll-related receptors and the control of antimicrobial peptide RT expression in Drosophila."; RL Proc. Natl. Acad. Sci. U.S.A. 97:10520-10525(2000). RN [2] {ECO:0000312|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000312|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000312|EMBL:ABA86520.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-1435. RC STRAIN=Ral1 {ECO:0000312|EMBL:ABA86520.1}; RX PubMed=16120803; DOI=10.1093/molbev/msi246; RA Comeron J.M., Guthrie T.B.; RT "Intragenic Hill-Robertson interference influences selection intensity RT on synonymous mutations in Drosophila."; RL Mol. Biol. Evol. 22:2519-2530(2005). RN [5] {ECO:0000312|EMBL:ADN32842.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-1031. RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000305} RP DEVELOPMENTAL STAGE. RX PubMed=12617819; DOI=10.1016/S1567-133X(02)00020-0; RA Kambris Z., Hoffmann J.A., Imler J.L., Capovilla M.; RT "Tissue and stage-specific expression of the Tolls in Drosophila RT embryos."; RL Gene Expr. Patterns 2:311-317(2002). RN [7] {ECO:0000305} RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE. RX PubMed=21158756; DOI=10.1111/j.1440-169X.2010.01213.x; RA Yagi Y., Nishida Y., Ip Y.T.; RT "Functional analysis of Toll-related genes in Drosophila."; RL Dev. Growth Differ. 52:771-783(2010). RN [8] {ECO:0000305} RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY VIRAL INFECTION, AND RP DISRUPTION PHENOTYPE. RX PubMed=22464169; DOI=10.1016/j.immuni.2012.03.003; RA Nakamoto M., Moy R.H., Xu J., Bambina S., Yasunaga A., Shelly S.S., RA Gold B., Cherry S.; RT "Virus recognition by Toll-7 activates antiviral autophagy in RT Drosophila."; RL Immunity 36:658-667(2012). RN [9] {ECO:0000305} RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE. RX PubMed=23892553; DOI=10.1038/nn.3474; RA McIlroy G., Foldi I., Aurikko J., Wentzell J.S., Lim M.A., RA Fenton J.C., Gay N.J., Hidalgo A.; RT "Toll-6 and Toll-7 function as neurotrophin receptors in the RT Drosophila melanogaster CNS."; RL Nat. Neurosci. 16:1248-1256(2013). RN [10] {ECO:0000305} RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE. RX PubMed=25741726; DOI=10.1016/j.neuron.2015.02.003; RA Ward A., Hong W., Favaloro V., Luo L.; RT "Toll receptors instruct axon and dendrite targeting and participate RT in synaptic partner matching in a Drosophila olfactory circuit."; RL Neuron 85:1013-1028(2015). CC -!- FUNCTION: Toll-related receptor which binds to the neurotrophins CC NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for CC antiviral autophagy, it detects and binds to the vesicular CC stomatitis virus (vsv) following infection (PubMed:22464169). This CC role is likely to be independent of the canonical Toll, immune CC deficiency, and JAK-STAT signaling pathways (PubMed:22464169). CC Functions in olfactory circuit assembly by promoting synaptic CC partner matching between olfactory receptor neurons (ORN) axons CC and projection neurons (PN) dendrites partners in the antennal CC lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and CC sufficient for correct targeting to their partner PN dendrites CC (PubMed:25741726). Also involved in the targeting of other classes CC of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate CC motor axon targeting and neuronal survival in the central nervous CC system (CNS) (PubMed:23892553). May be an upstream component of CC the NF-kappa-B (rel) regulatory cascade (PubMed:23892553). CC {ECO:0000269|PubMed:10973475, ECO:0000269|PubMed:22464169, CC ECO:0000269|PubMed:23892553, ECO:0000269|PubMed:25741726}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22464169}; CC Single-pass type I membrane protein {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Expressed in the fan-shaped body and the CC ellipsoid body, which are components of the locomotion center in CC the CNS (at protein level) (PubMed:23892553). CC {ECO:0000269|PubMed:23892553}. CC -!- DEVELOPMENTAL STAGE: In embryos, expressed in the ventral neurons, CC motor neurons and in the longitudinal interneuron axons (at CC protein level) (PubMed:23892553). May also be expressed in the CC motor neuron dendrites or possibly the glia (at protein level) CC (PubMed:23892553). Expressed 48 hours after puparium formation in CC the lateral glomeruli of the anterior and central regions of the CC antennal lobe, including the DA1, VA1d and VA1v glomeruli (at CC protein level) (PubMed:25741726). Expressed zygotically CC (PubMed:12617819). High levels of expression in embryos and pupae, CC and relatively low levels of expression in larvae and adults CC (PubMed:10973475). At germ band extension, expressed as 14 stripes CC in the embryo (PubMed:12617819). At germ band retraction, CC expressed in a subset of neurons in the CNS, the precursors of the CC leg imaginal disks and in the ventral epithelium of the large CC intestine (PubMed:12617819). Expressed in the posterior and CC anterior spiracles (PubMed:12617819). In stage 16 embryos, CC expression decreases and is mainly localized to the CNS CC (PubMed:12617819). Expressed in the proximal region of the wing CC imaginal disks, around the wing pouch and hinge regions CC (PubMed:21158756). Also expressed in the distal segments of the CC leg imaginal disks, with high levels of expression around the A-P CC border of the tarsal to tibia segments (PubMed:21158756). In CC larvae, detected in the fat body (PubMed:12617819). CC {ECO:0000269|PubMed:10973475, ECO:0000269|PubMed:12617819, CC ECO:0000269|PubMed:21158756, ECO:0000269|PubMed:23892553, CC ECO:0000269|PubMed:25741726}. CC -!- INDUCTION: Up-regulated during vesicular stomatitis virus (VSV) CC infection. {ECO:0000269|PubMed:22464169}. CC -!- DISRUPTION PHENOTYPE: Mistargeting of VA1d ORN axons to a medial CC position (PubMed:25741726). No effect on the immune response to CC septic injury using a mixture of Gram-positive and Gram-negative CC bacteria; adults are able induce expression of antibacterial CC peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate CC immune response (PubMed:21158756). RNAi-mediated knockdown results CC in adults that are acutely sensitive to the vesicular stomatitis CC virus (vsv) (PubMed:22464169). Following infection with vsv adult CC survival is decreased, and adults show a dramatic increase in CC viral RNA production 6 days post vsv infection and viral CC replication 9 days post infection (PubMed:22464169). Reduced CC autophagy in adult fat body cells following vsv infection CC (PubMed:22464169). Starvation-induced autophagy is not affected CC (PubMed:22464169). {ECO:0000269|PubMed:21158756, CC ECO:0000269|PubMed:22464169, ECO:0000269|PubMed:25741726}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF247765; AAF86225.1; -; mRNA. DR EMBL; DQ138914; ABA86520.1; -; Genomic_DNA. DR EMBL; AE013599; AAF57514.1; -; Genomic_DNA. DR EMBL; BT125656; ADN32842.1; -; mRNA. DR RefSeq; NP_523797.1; NM_079073.3. DR UniGene; Dm.2660; -. DR ProteinModelPortal; Q7KIN0; -. DR IntAct; Q7KIN0; 1. DR STRING; 7227.FBpp0085638; -. DR PaxDb; Q7KIN0; -. DR PRIDE; Q7KIN0; -. DR EnsemblMetazoa; FBtr0086336; FBpp0085638; FBgn0034476. DR GeneID; 37272; -. DR KEGG; dme:Dmel_CG8595; -. DR UCSC; CG8595-RA; d. melanogaster. DR CTD; 37272; -. DR FlyBase; FBgn0034476; Toll-7. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR GeneTree; ENSGT00760000118777; -. DR OMA; NHAFIGR; -. DR OrthoDB; EOG091G0137; -. DR PhylomeDB; Q7KIN0; -. DR GenomeRNAi; 37272; -. DR PRO; PR:Q7KIN0; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0034476; -. DR ExpressionAtlas; Q7KIN0; differential. DR GO; GO:0009897; C:external side of plasma membrane; IDA:FlyBase. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005030; F:neurotrophin receptor activity; IMP:FlyBase. DR GO; GO:0008329; F:signaling pattern recognition receptor activity; IC:FlyBase. DR GO; GO:0046790; F:virion binding; IDA:FlyBase. DR GO; GO:0007411; P:axon guidance; IMP:FlyBase. DR GO; GO:0002752; P:cell surface pattern recognition receptor signaling pathway; IC:FlyBase. DR GO; GO:0051607; P:defense response to virus; IMP:FlyBase. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0010508; P:positive regulation of autophagy; IMP:FlyBase. DR GO; GO:0050688; P:regulation of defense response to virus; IMP:FlyBase. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 5. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 5. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 20. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 23. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Developmental protein; KW Disulfide bond; Immunity; Innate immunity; Leucine-rich repeat; KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 16 {ECO:0000255}. FT CHAIN 17 1446 Toll-like receptor 7. FT /FTId=PRO_5006489795. FT TOPO_DOM 17 1049 Extracellular. {ECO:0000305}. FT TRANSMEM 1050 1070 Helical. {ECO:0000255}. FT TOPO_DOM 1071 1446 Cytoplasmic. {ECO:0000305}. FT REPEAT 133 156 LRR 1. {ECO:0000255}. FT REPEAT 158 180 LRR 2. {ECO:0000255}. FT REPEAT 188 211 LRR 3. {ECO:0000255}. FT REPEAT 213 235 LRR 4. {ECO:0000255}. FT REPEAT 246 270 LRR 5. {ECO:0000255}. FT REPEAT 271 294 LRR 6. {ECO:0000255}. FT REPEAT 295 318 LRR 7. {ECO:0000255}. FT REPEAT 320 342 LRR 8. {ECO:0000255}. FT REPEAT 344 368 LRR 9. {ECO:0000255}. FT REPEAT 369 392 LRR 10. {ECO:0000255}. FT REPEAT 393 416 LRR 11. {ECO:0000255}. FT REPEAT 417 440 LRR 12. {ECO:0000255}. FT REPEAT 442 464 LRR 13. {ECO:0000255}. FT REPEAT 465 488 LRR 14. {ECO:0000255}. FT REPEAT 489 511 LRR 15. {ECO:0000255}. FT REPEAT 513 535 LRR 16. {ECO:0000255}. FT REPEAT 536 559 LRR 17. {ECO:0000255}. FT REPEAT 561 582 LRR 18. {ECO:0000255}. FT REPEAT 584 605 LRR 19. {ECO:0000255}. FT REPEAT 606 629 LRR 20. {ECO:0000255}. FT REPEAT 631 652 LRR 21. {ECO:0000255}. FT REPEAT 653 675 LRR 22. {ECO:0000255}. FT REPEAT 677 699 LRR 23. {ECO:0000255}. FT DOMAIN 716 773 LRRCT. {ECO:0000255}. FT REPEAT 828 851 LRR 24. {ECO:0000255}. FT REPEAT 852 875 LRR 25. {ECO:0000255}. FT REPEAT 876 899 LRR 26. {ECO:0000255}. FT REPEAT 900 923 LRR 27. {ECO:0000255}. FT REPEAT 925 947 LRR 28. {ECO:0000255}. FT REPEAT 951 979 LRR 29. {ECO:0000255}. FT DOMAIN 1096 1236 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT DISULFID 722 772 {ECO:0000250|UniProtKB:P08953}. FT DISULFID 796 802 {ECO:0000250|UniProtKB:P08953}. FT DISULFID 800 815 {ECO:0000250|UniProtKB:P08953}. FT DISULFID 966 993 {ECO:0000250|UniProtKB:P08953}. FT CONFLICT 58 58 P -> L (in Ref. 4; ABA86520). FT {ECO:0000305}. FT CONFLICT 124 124 T -> K (in Ref. 4; ABA86520). FT {ECO:0000305}. FT CONFLICT 1426 1426 Missing (in Ref. 4; ABA86520). FT {ECO:0000305}. SQ SEQUENCE 1446 AA; 160950 MW; 80D281BDA9500ABC CRC64; MAAILLLLLG FSWSLAVESA LAPKESESSA SAMLGAGTGA AATVSLSGDY SSLLSNVPAA SPVPANPSQP SGPANQCSWS YNGTSSVHCA LRLIERQPGL DLQGADGSSQ LTIQCSELYL FESTLPVAVF ARLQTLEALR LDSCKLLQLP NNAFEGLATL KSLRLSTHNS EWGPTRTLEL FPDSLGGLKQ LTDLDLGDNN LRQLPSGFLC PVGNLQVLNL TRNRIRTAEQ MGFADMNCGA GSGSAGSELQ VLDASHNELR SISESWGISR LRRLQHLNLA YNNLSELSGE ALAGLASLRI VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD LSGNQLTSNH VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN LRNNSIGHIE DNAFLPLYNL HTLNLAENRL HTLDDKLFNG LYVLSKLTLN NNLISVVEPA VFKNCSDLKE LDLSSNQLNE VPRALQDLAM LRTLDLGENQ IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFQDLPRLS VLNLAKNRIQ SIERGSFDKN FELEAIRLDR NFLADINGVF ATLVSLLWLN LSENHLVWFD YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS IPNTIELLFI NNNLIGNVQP NAFVDKANLA RVDLYANQLS KLQLQQLRVA PVVAPKPLPE FYLGGNPFEC DCTMDWLQRI NNLTTRQHPR VMDMANIECV MPHARGAAVR PLSGLRPQDF LCRYESHCFA LCHCCDFDAC DCEMTCPSNC TCYHDQIWST NVVDCGGQQT TELPRRVPMD SSVVYLDGNN FPVLKNHAFI GRKNLRALYV NGSQVAAIQN RTFASLASLQ LLHLADNKLR TLHGYEFEQL SALRELYLQN NQLTTIENAT LAPLAALELI RIDGNRLVTL PIWQMHATHF GTRLKSISLG RNQWSCRCQF LQALTSYVAD NALIVQDAQD IYCMAASSGT GSAALEDSSS NSGSLEKREL DFNATGAACT DYYSGGSMLQ HGIPESYIPL LAAALALLFL LVVIAMVFAF RESLRIWLFA HYGVRVFGPR CEESEKLYDA VLLHSAKDSE FVCQHLAAQL ETGRPPLRVC LQHRDLAHDA THYQLLEATR VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA ESDIELLPYL KTSAVHRIRR SDRHFWEKLR YALPVDYPTF RGNNYTLELD HHNHERVKQP ASPGLLYRQA PPPAYCGPAD AVGIGAVPQV VPVNASVPAE QNYSTATTAT PSPRPQRRGE QPGSGSGGNH HLHAQYYQHH GMRPPSEHIY SSIDSDYSTL DNEQHMLMMP GAPGGLAMEA AQRAQTWRPK REQLHLQQAQ AGTLGSKASQ AAHQQQQQQQ QQQQQQPNPT AVSGQQQGPH VQAYLV // ID TOLL_DROME Reviewed; 1097 AA. AC P08953; A4V3G7; A8WHK7; Q8MRF3; Q9VBB8; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1988, sequence version 1. DT 28-MAR-2018, entry version 196. DE RecName: Full=Protein toll; DE Flags: Precursor; GN Name=Tl {ECO:0000312|FlyBase:FBgn0262473}; GN ORFNames=CG5490 {ECO:0000312|FlyBase:FBgn0262473}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=2449285; DOI=10.1016/0092-8674(88)90516-8; RA Hashimoto C., Hudson K.L., Anderson K.V.; RT "The Toll gene of Drosophila, required for dorsal-ventral embryonic RT polarity, appears to encode a transmembrane protein."; RL Cell 52:269-279(1988). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., RA Yu C., Celniker S.E.; RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-1097, AND VARIANTS. RC STRAIN=MelZim1, MelZim3, MelZim4, MelZim5, MelZim6, MelZim7, and RC MelZim8; RX PubMed=12930753; RA Schlenke T.A., Begun D.J.; RT "Natural selection drives Drosophila immune system evolution."; RL Genetics 164:1471-1480(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 366-1097. RC STRAIN=Berkeley; TISSUE=Head; RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). RN [7] RP FUNCTION. RX PubMed=3931919; DOI=10.1016/0092-8674(85)90275-2; RA Anderson K.V., Bokla L., Nusslein-Volhard C.; RT "Establishment of dorsal-ventral polarity in the Drosophila embryo: RT the induction of polarity by the Toll gene product."; RL Cell 42:791-798(1985). RN [8] RP FUNCTION. RX PubMed=2124970; RA Keith F.J., Gay N.J.; RT "The Drosophila membrane receptor Toll can function to promote RT cellular adhesion."; RL EMBO J. 9:4299-4306(1990). RN [9] RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE. RX PubMed=1879347; RA Hashimoto C., Gerttula S., Anderson K.V.; RT "Plasma membrane localization of the Toll protein in the syncytial RT Drosophila embryo: importance of transmembrane signaling for dorsal- RT ventral pattern formation."; RL Development 111:1021-1028(1991). RN [10] RP FUNCTION. RX PubMed=8808632; DOI=10.1016/S0092-8674(00)80172-5; RA Lemaitre B., Nicolas E., Michaut L., Reichhart J.-M., Hoffmann J.A.; RT "The dorsoventral regulatory gene cassette spatzle/Toll/cactus RT controls the potent antifungal response in Drosophila adults."; RL Cell 86:973-983(1996). RN [11] RP FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=10973475; DOI=10.1073/pnas.180130797; RA Tauszig S., Jouanguy E., Hoffmann J.A., Imler J.L.; RT "Toll-related receptors and the control of antimicrobial peptide RT expression in Drosophila."; RL Proc. Natl. Acad. Sci. U.S.A. 97:10520-10525(2000). RN [12] RP DEVELOPMENTAL STAGE. RX PubMed=12617819; DOI=10.1016/S1567-133X(02)00020-0; RA Kambris Z., Hoffmann J.A., Imler J.L., Capovilla M.; RT "Tissue and stage-specific expression of the Tolls in Drosophila RT embryos."; RL Gene Expr. Patterns 2:311-317(2002). RN [13] RP FUNCTION. RX PubMed=12872120; DOI=10.1038/ni955; RA Weber A.N., Tauszig-Delamasure S., Hoffmann J.A., Lelievre E., RA Gascan H., Ray K.P., Morse M.A., Imler J.L., Gay N.J.; RT "Binding of the Drosophila cytokine Spatzle to Toll is direct and RT establishes signaling."; RL Nat. Immunol. 4:794-800(2003). RN [14] RP SUBCELLULAR LOCATION. RX PubMed=15373972; DOI=10.1179/096805104225004897; RA Bettencourt R., Tanji T., Yagi Y., Ip Y.T.; RT "Toll and Toll-9 in Drosophila innate immune response."; RL J. Endotoxin Res. 10:261-268(2004). RN [15] RP FUNCTION, AND DEVELOPMENTAL STAGE. RX PubMed=19018662; DOI=10.1371/journal.pbio.0060284; RA Zhu B., Pennack J.A., McQuilton P., Forero M.G., Mizuguchi K., RA Sutcliffe B., Gu C.-J., Fenton J.C., Hidalgo A.; RT "Drosophila neurotrophins reveal a common mechanism for nervous system RT formation."; RL PLoS Biol. 6:E284-E284(2008). RN [16] RP INDUCTION BY VIRAL INFECTION. RX PubMed=22464169; DOI=10.1016/j.immuni.2012.03.003; RA Nakamoto M., Moy R.H., Xu J., Bambina S., Yasunaga A., Shelly S.S., RA Gold B., Cherry S.; RT "Virus recognition by Toll-7 activates antiviral autophagy in RT Drosophila."; RL Immunity 36:658-667(2012). RN [17] RP FUNCTION, AND TISSUE SPECIFICITY. RX PubMed=20504957; DOI=10.1242/dev.046672; RA Inaki M., Shinza-Kameda M., Ismat A., Frasch M., Nose A.; RT "Drosophila Tey represses transcription of the repulsive cue Toll and RT generates neuromuscular target specificity."; RL Development 137:2139-2146(2010). RN [18] RP X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 28-228. RX PubMed=23596340; DOI=10.1107/S0021889812051606; RA Gangloff M., Moreno A., Gay N.J.; RT "Liesegang-like patterns of Toll crystals grown in gel."; RL J. Appl. Crystallogr. 46:337-345(2013). RN [19] RP X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 28-397 IN COMPLEX WITH SPZ, RP AND SUBUNIT. RX PubMed=24282309; DOI=10.1073/pnas.1317002110; RA Lewis M., Arnot C.J., Beeston H., McCoy A., Ashcroft A.E., Gay N.J., RA Gangloff M.; RT "Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a RT neurotrophin-like specificity and couples receptor activation."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20461-20466(2013). RN [20] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 28-228, AND MUTAGENESIS OF RP ARG-154; LYS-208 AND ARG-432. RX PubMed=23245851; DOI=10.1016/j.str.2012.11.003; RA Gangloff M., Arnot C.J., Lewis M., Gay N.J.; RT "Functional insights from the crystal structure of the N-terminal RT domain of the prototypical toll receptor."; RL Structure 21:143-153(2013). RN [21] RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 28-802 IN COMPLEX WITH SPZ, RP AND SUBUNIT. RX PubMed=24733933; DOI=10.1073/pnas.1320678111; RA Parthier C., Stelter M., Ursel C., Fandrich U., Lilie H., RA Breithaupt C., Stubbs M.T.; RT "Structure of the Toll-Spatzle complex, a molecular hub in Drosophila RT development and innate immunity."; RL Proc. Natl. Acad. Sci. U.S.A. 111:6281-6286(2014). CC -!- FUNCTION: Receptor for the cleaved activated form of spz, spaetzle CC C-106 (PubMed:12872120). Binding to spaetzle C-106 activates the CC Toll signaling pathway and induces expression of the antifungal CC peptide drosomycin (PubMed:12872120, PubMed:8808632, CC PubMed:10973475). Component of the extracellular signaling pathway CC that establishes dorsal-ventral polarity in the embryo CC (PubMed:3931919). Promotes heterophilic cellular adhesion CC (PubMed:2124970). Involved in synaptic targeting of motoneurons CC RP5 and V to muscle 12 (M12); functions as a repulsive cue CC inhibiting motoneuron synapse formation on muscle 13 (M13) to CC guide RP5 and V to the neighboring M12, where its expression is CC repressed by tey (PubMed:20504957). May also function in embryonic CC neuronal survival and the synaptic targeting of SNa motoneurons CC (PubMed:19018662). {ECO:0000269|PubMed:10973475, CC ECO:0000269|PubMed:12872120, ECO:0000269|PubMed:19018662, CC ECO:0000269|PubMed:20504957, ECO:0000269|PubMed:2124970, CC ECO:0000269|PubMed:3931919, ECO:0000269|PubMed:8808632}. CC -!- SUBUNIT: In the absence of ligand, forms a low-affinity disulfide- CC linked homodimer (PubMed:24733933). In the presence of ligand, CC crystal structures show one Tl molecule bound to a spaetzle C-106 CC homodimer (PubMed:24282309, PubMed:24733933). However, the active CC complex probably consists of two Tl molecules bound to a spaetzle CC C-106 homodimer (PubMed:24282309, PubMed:24733933). This is CC supported by in vitro experiments which also show binding of the CC spaetzle C-106 dimer to 2 Tl receptors (PubMed:12872120). Ligand CC binding induces conformational changes in the extracellular domain CC of Tl (PubMed:24282309). This may enable a secondary CC homodimerization interface at the C-terminus of the Tl CC extracellular domain (PubMed:24282309). CC {ECO:0000269|PubMed:12872120, ECO:0000269|PubMed:24282309, CC ECO:0000269|PubMed:24733933, ECO:0000303|PubMed:24282309}. CC -!- INTERACTION: CC Self; NbExp=2; IntAct=EBI-143610, EBI-143610; CC Q7K105:Myd88; NbExp=3; IntAct=EBI-143610, EBI-129988; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15373972, CC ECO:0000269|PubMed:1879347}; Single-pass type I membrane protein CC {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:15373972}. Note=In CC the fat body, detected in puntate structures along the cell CC periphery. Becomes evenly distributed in the cytoplasm 1 hour CC after bacterial infection. {ECO:0000269|PubMed:15373972}. CC -!- TISSUE SPECIFICITY: In early embryos, concentrated in the CC pseudocleavage furrows that form transiently between nuclei before CC cellularization and in the cleavage furrows during cellularization CC (at protein level) (PubMed:1879347). Later, found on cells in the CC mesectoderm, stomodeum, proctodeum, anterior and posterior CC midguts, splanchnopleura, salivary gland placode and adjacent to CC the segmentally repeated tracheal placodes (at protein level) CC (PubMed:1879347). During and after germ band shortening, localized CC in a number of cell types, including the salivary gland, foregut, CC hindgut, Malpighian tubules and epidermis (at protein level) CC (PubMed:1879347). In embryos, high expression in M13 with CC comparatively low expression in M12 (PubMed:20504957). CC {ECO:0000269|PubMed:1879347, ECO:0000269|PubMed:20504957}. CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically CC (PubMed:2449285, PubMed:1879347, PubMed:12617819). Maternal Tl CC increases in syncytial embryos, reaching a peak at the syncytial CC blastoderm stage and then decreases and is almost undetectable by CC the time of ventral furrow formation at gastrulation (at protein CC level) (PubMed:1879347). Expressed throughout development, with CC highest levels of expression in the embryo (PubMed:10973475). CC Expressed in all embryonic central nervous system axons CC (PubMed:19018662). In larvae, detected in the blood cells and fat CC body (PubMed:12617819). {ECO:0000269|PubMed:10973475, CC ECO:0000269|PubMed:12617819, ECO:0000269|PubMed:1879347, CC ECO:0000269|PubMed:19018662, ECO:0000269|PubMed:2449285}. CC -!- INDUCTION: Up-regulated during vesicular stomatitis virus (VSV) CC infection. {ECO:0000269|PubMed:22464169}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000305}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M19969; AAA28941.1; -; mRNA. DR EMBL; AE014297; AAF56624.1; -; Genomic_DNA. DR EMBL; AE014297; AAN14086.1; -; Genomic_DNA. DR EMBL; BT031153; ABX00775.1; -; mRNA. DR EMBL; AY349649; AAQ64932.1; -; Genomic_DNA. DR EMBL; AY349650; AAQ64933.1; -; Genomic_DNA. DR EMBL; AY349651; AAQ64934.1; -; Genomic_DNA. DR EMBL; AY349652; AAQ64935.1; -; Genomic_DNA. DR EMBL; AY349653; AAQ64936.1; -; Genomic_DNA. DR EMBL; AY349654; AAQ64937.1; -; Genomic_DNA. DR EMBL; AY349655; AAQ64938.1; -; Genomic_DNA. DR EMBL; AY121616; AAM51943.1; -; mRNA. DR PIR; A29943; A29943. DR RefSeq; NP_524518.1; NM_079794.3. DR RefSeq; NP_733166.1; NM_170287.3. DR UniGene; Dm.2347; -. DR PDB; 4ARN; X-ray; 2.41 A; A/B/C/D=28-228. DR PDB; 4ARR; X-ray; 3.00 A; A/B=28-228. DR PDB; 4BV4; X-ray; 2.35 A; R=28-397. DR PDB; 4LXR; X-ray; 2.20 A; A=28-802. DR PDB; 4LXS; X-ray; 3.30 A; A=28-802. DR PDBsum; 4ARN; -. DR PDBsum; 4ARR; -. DR PDBsum; 4BV4; -. DR PDBsum; 4LXR; -. DR PDBsum; 4LXS; -. DR ProteinModelPortal; P08953; -. DR SMR; P08953; -. DR BioGrid; 68116; 22. DR DIP; DIP-34358N; -. DR IntAct; P08953; 6. DR MINT; P08953; -. DR STRING; 7227.FBpp0303187; -. DR PaxDb; P08953; -. DR PRIDE; P08953; -. DR EnsemblMetazoa; FBtr0085059; FBpp0084431; FBgn0262473. DR EnsemblMetazoa; FBtr0330155; FBpp0303188; FBgn0262473. DR GeneID; 43222; -. DR KEGG; dme:Dmel_CG5490; -. DR CTD; 109651; -. DR FlyBase; FBgn0262473; Tl. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR InParanoid; P08953; -. DR KO; K18809; -. DR OMA; PAIMIAN; -. DR OrthoDB; EOG091G00ZN; -. DR PhylomeDB; P08953; -. DR Reactome; R-DME-209442; Formation of the trans-membrane 'signalling complex'. DR Reactome; R-DME-214842; DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'. DR Reactome; R-DME-214844; DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'. DR Reactome; R-DME-214862; Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'. DR Reactome; R-DME-214863; Adaptor protein complex binds to TL receptor at the plasma membrane. DR Reactome; R-DME-214869; Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'. DR Reactome; R-DME-214874; PLL kinase binds to TUB in the TL receptor 'signalling complex'. DR ChiTaRS; Tl; fly. DR GenomeRNAi; 43222; -. DR PRO; PR:P08953; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0262473; -. DR ExpressionAtlas; P08953; differential. DR Genevisible; P08953; DM. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0032154; C:cleavage furrow; IDA:UniProtKB. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005769; C:early endosome; IDA:FlyBase. DR GO; GO:0009897; C:external side of plasma membrane; IDA:FlyBase. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0043234; C:protein complex; IPI:FlyBase. DR GO; GO:0019955; F:cytokine binding; TAS:FlyBase. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0070976; F:TIR domain binding; IPI:FlyBase. DR GO; GO:0004888; F:transmembrane signaling receptor activity; NAS:FlyBase. DR GO; GO:0019732; P:antifungal humoral response; IMP:FlyBase. DR GO; GO:0019730; P:antimicrobial humoral response; IGI:FlyBase. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR GO; GO:0006952; P:defense response; TAS:FlyBase. DR GO; GO:0050832; P:defense response to fungus; TAS:FlyBase. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; TAS:FlyBase. DR GO; GO:0002229; P:defense response to oomycetes; IMP:FlyBase. DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB. DR GO; GO:0009880; P:embryonic pattern specification; TAS:FlyBase. DR GO; GO:0007507; P:heart development; IMP:FlyBase. DR GO; GO:0035172; P:hemocyte proliferation; IMP:FlyBase. DR GO; GO:0030097; P:hemopoiesis; TAS:FlyBase. DR GO; GO:0006955; P:immune response; TAS:FlyBase. DR GO; GO:0045087; P:innate immune response; IDA:FlyBase. DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase. DR GO; GO:0006963; P:positive regulation of antibacterial peptide biosynthetic process; IMP:FlyBase. DR GO; GO:0006967; P:positive regulation of antifungal peptide biosynthetic process; IMP:FlyBase. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase. DR GO; GO:1902875; P:regulation of embryonic pattern specification; IMP:UniProtKB. DR GO; GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase. DR GO; GO:0035007; P:regulation of melanization defense response; TAS:FlyBase. DR GO; GO:0009617; P:response to bacterium; NAS:FlyBase. DR GO; GO:0009620; P:response to fungus; TAS:FlyBase. DR GO; GO:0007416; P:synapse assembly; IMP:FlyBase. DR GO; GO:0016201; P:synaptic target inhibition; IMP:FlyBase. DR GO; GO:0008063; P:Toll signaling pathway; TAS:Reactome. DR GO; GO:0007352; P:zygotic specification of dorsal/ventral axis; NAS:FlyBase. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000372; LRRNT. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01462; LRRNT; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00082; LRRCT; 2. DR SMART; SM00013; LRRNT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell adhesion; Cell membrane; Complete proteome; KW Cytoplasm; Developmental protein; Disulfide bond; Glycoprotein; KW Immunity; Innate immunity; Leucine-rich repeat; Membrane; KW Polymorphism; Receptor; Reference proteome; Repeat; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1 27 {ECO:0000255}. FT CHAIN 28 1097 Protein toll. FT /FTId=PRO_0000034740. FT TOPO_DOM 28 807 Extracellular. {ECO:0000255}. FT TRANSMEM 808 828 Helical. {ECO:0000255}. FT TOPO_DOM 829 1097 Cytoplasmic. {ECO:0000255}. FT REPEAT 175 195 LRR 1. FT REPEAT 198 219 LRR 2. FT REPEAT 222 243 LRR 3. FT REPEAT 246 267 LRR 4. FT REPEAT 270 291 LRR 5. FT REPEAT 294 314 LRR 6. FT REPEAT 320 340 LRR 7. FT REPEAT 343 364 LRR 8. FT REPEAT 367 388 LRR 9. FT REPEAT 391 412 LRR 10. FT REPEAT 415 436 LRR 11. FT REPEAT 439 460 LRR 12. FT REPEAT 474 495 LRR 13. FT REPEAT 498 521 LRR 14. FT REPEAT 523 544 LRR 15. FT DOMAIN 561 620 LRRCT 1. FT DOMAIN 622 663 LRRNT. FT REPEAT 669 690 LRR 16. FT REPEAT 693 713 LRR 17. FT REPEAT 715 738 LRR 18. FT DOMAIN 751 801 LRRCT 2. FT DOMAIN 857 996 TIR. {ECO:0000255|PROSITE- FT ProRule:PRU00204}. FT CARBOHYD 80 80 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4ARN, FT ECO:0000244|PDB:4ARR, FT ECO:0000244|PDB:4BV4, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 140 140 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4ARN, FT ECO:0000244|PDB:4ARR, FT ECO:0000244|PDB:4BV4, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 175 175 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXS}. FT CARBOHYD 235 235 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXS}. FT CARBOHYD 270 270 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4BV4, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 275 275 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 346 346 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4BV4, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 391 391 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4BV4, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 482 482 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 508 508 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 528 528 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 654 654 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXS}. FT CARBOHYD 677 677 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 703 703 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT CARBOHYD 715 715 N-linked (GlcNAc...) asparagine. FT {ECO:0000244|PDB:4LXR}. FT CARBOHYD 730 730 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT CARBOHYD 738 738 N-linked (GlcNAc...) asparagine. FT {ECO:0000255}. FT DISULFID 34 45 {ECO:0000244|PDB:4ARN, FT ECO:0000244|PDB:4ARR, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 43 56 {ECO:0000244|PDB:4ARN, FT ECO:0000244|PDB:4ARR, FT ECO:0000244|PDB:4BV4, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 79 107 {ECO:0000244|PDB:4ARN, FT ECO:0000244|PDB:4ARR, FT ECO:0000244|PDB:4BV4, FT ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 565 597 {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 567 618 {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 631 637 {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 635 650 {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 755 781 {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT DISULFID 757 799 {ECO:0000244|PDB:4LXR, FT ECO:0000244|PDB:4LXS}. FT VARIANT 98 98 E -> G (in strain: MelZim6). FT VARIANT 218 218 G -> S (in strain: MelZim7). FT VARIANT 245 245 T -> S (in strain: MelZim3). FT VARIANT 390 390 T -> I (in strain: MelZim3 and MelZim7). FT VARIANT 414 414 G -> A (in strain: MelZim3). FT VARIANT 435 435 V -> L (in strain: MelZim8). FT VARIANT 460 460 M -> T (in strain: MelZim6). FT VARIANT 471 471 Y -> D (in strain: MelZim1, MelZim4, FT MelZim5 and MelZim6). FT VARIANT 486 486 I -> R (in strain: MelZim6). FT VARIANT 513 513 G -> R (in strain: MelZim1, MelZim5 and FT MelZim6). FT VARIANT 538 538 A -> E (in strain: MelZim1, MelZim5 and FT MelZim6). FT VARIANT 544 544 H -> Y (in strain: MelZim1, MelZim5 and FT MelZim6). FT VARIANT 568 568 T -> M (in strain: MelZim1, MelZim5 and FT MelZim6). FT VARIANT 592 592 T -> A (in strain: MelZim6). FT VARIANT 603 603 L -> M (in strain: MelZim1, MelZim5 and FT MelZim6). FT VARIANT 681 681 L -> V (in strain: MelZim1, MelZim3, FT MelZim4, MelZim5, MelZim6 and MelZim7). FT VARIANT 714 714 T -> I (in strain: MelZim5 and MelZim8). FT VARIANT 732 732 T -> S (in strain: MelZim8). FT VARIANT 741 741 M -> I (in strain: MelZim1). FT MUTAGEN 154 154 R->A: No change in signaling capacity. FT {ECO:0000269|PubMed:23245851}. FT MUTAGEN 208 208 K->E: 25% decrease in signaling capacity. FT {ECO:0000269|PubMed:23245851}. FT MUTAGEN 432 432 R->A: 33% decrease in signaling capacity. FT {ECO:0000269|PubMed:23245851}. FT CONFLICT 355 355 K -> S (in Ref. 5; AAQ64932/AAQ64933/ FT AAQ64934/AAQ64935/AAQ64936/AAQ64937/ FT AAQ64938). {ECO:0000305}. FT CONFLICT 602 602 V -> A (in Ref. 5; AAQ64933/AAQ64934/ FT AAQ64937/AAQ64938). {ECO:0000305}. FT CONFLICT 786 786 M -> I (in Ref. 4; ABX00775). FT {ECO:0000305}. FT CONFLICT 825 825 A -> T (in Ref. 4; ABX00775). FT {ECO:0000305}. FT HELIX 31 36 {ECO:0000244|PDB:4LXR}. FT TURN 37 40 {ECO:0000244|PDB:4LXR}. FT STRAND 42 48 {ECO:0000244|PDB:4LXR}. FT STRAND 51 57 {ECO:0000244|PDB:4LXR}. FT STRAND 64 70 {ECO:0000244|PDB:4LXR}. FT STRAND 72 79 {ECO:0000244|PDB:4LXR}. FT HELIX 84 89 {ECO:0000244|PDB:4LXR}. FT STRAND 97 106 {ECO:0000244|PDB:4LXR}. FT STRAND 111 113 {ECO:0000244|PDB:4ARN}. FT HELIX 115 121 {ECO:0000244|PDB:4LXR}. FT STRAND 124 126 {ECO:0000244|PDB:4ARR}. FT STRAND 128 133 {ECO:0000244|PDB:4LXR}. FT HELIX 143 146 {ECO:0000244|PDB:4LXR}. FT STRAND 153 158 {ECO:0000244|PDB:4LXR}. FT TURN 167 172 {ECO:0000244|PDB:4LXR}. FT STRAND 177 183 {ECO:0000244|PDB:4LXR}. FT HELIX 190 193 {ECO:0000244|PDB:4LXR}. FT STRAND 201 203 {ECO:0000244|PDB:4LXR}. FT HELIX 217 219 {ECO:0000244|PDB:4LXR}. FT STRAND 225 227 {ECO:0000244|PDB:4LXR}. FT HELIX 238 241 {ECO:0000244|PDB:4LXR}. FT STRAND 249 251 {ECO:0000244|PDB:4LXR}. FT TURN 262 267 {ECO:0000244|PDB:4LXR}. FT STRAND 273 275 {ECO:0000244|PDB:4LXR}. FT TURN 286 291 {ECO:0000244|PDB:4LXR}. FT STRAND 297 300 {ECO:0000244|PDB:4LXR}. FT TURN 312 315 {ECO:0000244|PDB:4LXR}. FT STRAND 323 326 {ECO:0000244|PDB:4LXR}. FT TURN 335 340 {ECO:0000244|PDB:4LXR}. FT STRAND 346 348 {ECO:0000244|PDB:4LXR}. FT TURN 359 364 {ECO:0000244|PDB:4LXR}. FT STRAND 370 372 {ECO:0000244|PDB:4LXR}. FT TURN 383 386 {ECO:0000244|PDB:4LXR}. FT STRAND 394 396 {ECO:0000244|PDB:4LXR}. FT TURN 409 412 {ECO:0000244|PDB:4LXR}. FT STRAND 418 420 {ECO:0000244|PDB:4LXR}. FT TURN 431 434 {ECO:0000244|PDB:4LXR}. FT STRAND 442 444 {ECO:0000244|PDB:4LXR}. FT HELIX 456 460 {ECO:0000244|PDB:4LXR}. FT HELIX 468 471 {ECO:0000244|PDB:4LXR}. FT STRAND 477 479 {ECO:0000244|PDB:4LXR}. FT HELIX 490 494 {ECO:0000244|PDB:4LXR}. FT STRAND 501 503 {ECO:0000244|PDB:4LXR}. FT STRAND 511 513 {ECO:0000244|PDB:4LXS}. FT HELIX 514 517 {ECO:0000244|PDB:4LXR}. FT STRAND 526 528 {ECO:0000244|PDB:4LXR}. FT STRAND 536 538 {ECO:0000244|PDB:4LXS}. FT STRAND 554 557 {ECO:0000244|PDB:4LXR}. FT HELIX 567 569 {ECO:0000244|PDB:4LXR}. FT HELIX 570 576 {ECO:0000244|PDB:4LXR}. FT STRAND 577 579 {ECO:0000244|PDB:4LXR}. FT HELIX 584 586 {ECO:0000244|PDB:4LXR}. FT STRAND 588 591 {ECO:0000244|PDB:4LXR}. FT STRAND 596 600 {ECO:0000244|PDB:4LXR}. FT TURN 601 605 {ECO:0000244|PDB:4LXR}. FT HELIX 608 610 {ECO:0000244|PDB:4LXR}. FT HELIX 613 615 {ECO:0000244|PDB:4LXR}. FT STRAND 617 619 {ECO:0000244|PDB:4LXR}. FT STRAND 636 640 {ECO:0000244|PDB:4LXR}. FT TURN 641 644 {ECO:0000244|PDB:4LXR}. FT STRAND 645 649 {ECO:0000244|PDB:4LXR}. FT STRAND 670 674 {ECO:0000244|PDB:4LXR}. FT HELIX 691 693 {ECO:0000244|PDB:4LXR}. FT STRAND 695 698 {ECO:0000244|PDB:4LXR}. FT HELIX 709 711 {ECO:0000244|PDB:4LXR}. FT STRAND 718 720 {ECO:0000244|PDB:4LXR}. FT STRAND 723 725 {ECO:0000244|PDB:4LXS}. FT HELIX 731 737 {ECO:0000244|PDB:4LXR}. FT STRAND 745 747 {ECO:0000244|PDB:4LXR}. FT HELIX 757 759 {ECO:0000244|PDB:4LXR}. FT HELIX 760 767 {ECO:0000244|PDB:4LXR}. FT TURN 770 772 {ECO:0000244|PDB:4LXR}. FT HELIX 776 778 {ECO:0000244|PDB:4LXR}. FT HELIX 790 792 {ECO:0000244|PDB:4LXR}. FT HELIX 795 798 {ECO:0000244|PDB:4LXR}. SQ SEQUENCE 1097 AA; 124656 MW; D1BFC42245E3EABE CRC64; MSRLKAASEL ALLVIILQLL QWPGSEASFG RDACSEMSID GLCQCAPIMS EYEIICPANA ENPTFRLTIQ PKDYVQIMCN LTDTTDYQQL PKKLRIGEVD RVQMRRCMLP GHTPIASILD YLGIVSPTTL IFESDNLGMN ITRQHLDRLH GLKRFRFTTR RLTHIPANLL TDMRNLSHLE LRANIEEMPS HLFDDLENLE SIEFGSNKLR QMPRGIFGKM PKLKQLNLWS NQLHNLTKHD FEGATSVLGI DIHDNGIEQL PHDVFAHLTN VTDINLSANL FRSLPQGLFD HNKHLNEVRL MNNRVPLATL PSRLFANQPE LQILRLRAEL QSLPGDLFEH STQITNISLG DNLLKTLPAT LLEHQVNLLS LDLSNNRLTH LPDSLFAHTT NLTDLRLEDN LLTGISGDIF SNLGNLVTLV MSRNRLRTID SRAFVSTNGL RHLHLDHNDI DLQQPLLDIM LQTQINSPFG YMHGLLTLNL RNNSIIFVYN DWKNTMLQLR ELDLSYNNIS SLGYEDLAFL SQNRLHVNMT HNKIRRIALP EDVHLGEGYN NNLVHVDLND NPLVCDCTIL WFIQLVRGVH KPQYSRQFKL RTDRLVCSQP NVLEGTPVRQ IEPQTLICPL DFSDDPRERK CPRGCNCHVR TYDKALVINC HSGNLTHVPR LPNLHKNMQL MELHLENNTL LRLPSANTPG YESVTSLHLA GNNLTSIDVD QLPTNLTHLD ISWNHLQMLN ATVLGFLNRT MKWRSVKLSG NPWMCDCTAK PLLLFTQDNF ERIGDRNEMM CVNAEMPTRM VELSTNDICP AEKGVFIALA VVIALTGLLA GFTAALYYKF QTEIKIWLYA HNLLLWFVTE EDLDKDKKFD AFISYSHKDQ SFIEDYLVPQ LEHGPQKFQL CVHERDWLVG GHIPENIMRS VADSRRTIIV LSQNFIKSEW ARLEFRAAHR SALNEGRSRI IVIIYSDIGD VEKLDEELKA YLKMNTYLKW GDPWFWDKLR FALPHRRPVG NIGNGALIKT ALKGSTDDKL ELIKPSPVTP PLTTPPAEAT KNPLVAQLNG VTPHQAIMIA NGKNGLTNLY TPNGKSHGNG HINGAFIINT NAKQSDV // ID U3I841_ANAPL Unreviewed; 669 AA. AC U3I841; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSAPLP00000003412}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSAPLP00000003412}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000003412, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000003412} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000003412} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000003412} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADON01090146; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090147; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090148; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090149; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090150; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090151; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090152; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090153; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090154; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01090155; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAPLT00000004013; ENSAPLP00000003412; ENSAPLG00000003925. DR GeneTree; ENSGT00760000119071; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 223 244 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 333 354 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 80 205 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 215 323 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 376 535 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 669 AA; 77031 MW; 5D52A42D72B4D614 CRC64; VDGCTDWSVD YKKYQVLVGE PVRIKCALFY GYIRANYSLA QSAGLSLMWY KSSGPGDFEE PIAFDGTRMS KEEDSIWFRP TVVQDSGLYA CVIRNSTYCM KVSISLTVGE NDTGLCYNSK MKYFEKAELS KSKEISCPEV EDFLFPFREP EILWYKECKS KTWRSSIVFK KDTLVIREVR EDDIGNYTCE VKYGIFVVRR TTELTVTAPL TDKPPKLLHP LEIFFFFSFF VTGGSANLTC RAFFGYSGDV SPLIYWMKGE KFIEDLDDSR VWESDIRVLK EHLGEQEVSI SLILDSVEEG DLGNYSCYVE NGNGRRHASI LLHKRELMYT VELAGGLGAI LLLLVCLVTI YKCYKIEIML FYRNHFGAEE LDGDNKDYDA YLSYTKVDPD QWNQETGEEE RFALEILPDM LEKHYGYKLF IPDRDLIPTG TYIEDVARCV DQSKRLIIVM TPNYVVRRGW SIFELETRLR NMLVTGEIKV ILIECSELRG VMNYQEVEAL KHTIKLLTVI KWHGPKCNKL NSKFWKRLQY EMPFKRTEPI THEQVLDVSE QGPFGELQTV SAISMAAATS TALATAHPDL RSTFHNTYHS QMRQKHYYRS YEYDVPPTGT LPLTSIGNQH TYCNIPMTLI NGQRPQTKTN REQNPEEAHT NSAILPLLPR ETSISSVIW // ID U3I8Q9_ANAPL Unreviewed; 1048 AA. AC U3I8Q9; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 39. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSAPLP00000003630}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSAPLP00000003630}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000003630, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000003630} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000003630} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000003630} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADON01133867; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAPLT00000004233; ENSAPLP00000003630; ENSAPLG00000004139. DR GeneTree; ENSGT00760000119006; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 839 863 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 888 1035 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1048 AA; 120894 MW; BA1CE5E877879729 CRC64; LCFYWTVKMQ ADIKVYLFLF PLLLSGAWFP KSLPCDVEAS EGSVRVDCSD RRLTEVPRGI PANATNLTLT INHIPHIYPT SFAYLERLVE IDFRCNCVPV RLGPKDHVCT RTPTIENGSF AALTRLKSLY LDANQLSEIP RGLPSTLSLL SLEANSISSI QKANLSELRN IEILYLGQNC YYRNPCNVSF EIEQTAFLDL KNLTVLSLKS NNITHIPPNL SSTLKELYIY NNIIQEVQEY DLSALHNLEI LDLSGNCPRC YNAPYPCVPC PNNALKIHSK AFYSLKKLRI LRLHSNSLRN IPSSWFKNTR NLEELDLSQN FLMKEIGDAQ FLKFVPRLVE LDLSFNFELQ MYSPSLNLSK TFSTLSNLEI LRIRGYVFKE LKKENLYPLL NLRNLTVLDL GTNFIKVADL TVFKRFQALK VIDLSVNKIS PSSSESNSYG ICSNPRISVE QRNRQVLQEM HYFRYDEYGR SCKSKDKEAN SYRPSVNRDC LDYGKTLDLS RNNIFFISPS DFQDLDFLRC LNLSGNAISQ TLNGSEFHYL SGLKYLDFSN NRIDLLYSTA FEELKLLEIL DLSNNKHYFL AEGVTHVLNF MKNLAYLKKL MMNENEISTS ISTGMESQSL KILEFRGNRL DVLWMDGNAR YLSFFKNLTN LEKLDISFNS LSFLPSDVFE AMPPELKILN LTNNRLKAFK WGKLYLLKKL TTLDLSNNLL TTVPRELSNC TSTLQELILR NNHIQRLTKY FLRGAIGLQY LDLSSNKIQI IKKSSFPENV INNLKMLLLH GNPFKCNCDA VWFVWWINQT QVTIPLLATD VTCAGPGAHK GKSLVFLDLY TCELDTSYLI MYALSASAVL GFMVFAVMSH LYFWDVWYSY HYCTAKLKGY RRLPLQDTCY DAFIAFDNTD PAVNEWVMTE LVEKLEDQKT RKFNLCLEER DWLPGQPVFD NLSQSIQLSK KTIFVLTNKY IKSGSFKTTF YMAHQRLLDE KIDVIILIFL EKILQKSRYV RLRKRLCRSS VLEWPTNPRS QPYFWQTLKN AIATCNTLAY NNLLQETV // ID U3I9U3_ANAPL Unreviewed; 554 AA. AC U3I9U3; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000004014}; GN Name=LOC101794055 {ECO:0000313|Ensembl:ENSAPLP00000004014}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000004014, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000004014} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000004014} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000004014} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADON01033466; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01033467; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01033468; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; U3I9U3; -. DR Ensembl; ENSAPLT00000004621; ENSAPLP00000004014; ENSAPLG00000004478. DR GeneTree; ENSGT00760000119071; -. DR OMA; IQDYEKM; -. DR OrthoDB; EOG091G03IT; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004076; IL-1_rcpt_I-typ. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01538; INTRLEUKN1R1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 554 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004643355. FT TRANSMEM 340 362 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 16 109 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 136 215 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 386 543 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 554 AA; 63837 MW; 8544F6BD9455CE35 CRC64; MTSTFLLIGH LILLIPLFSA EECIVCDYFV LVGEPTAISC PVITLPALHS DYNMTWYKNG SNTPITTEKN ARIHVRKGLL WFIPATLEDS GLYECEVRGL NRSNQKTINL KVFKNDNGLC FNGKMKYEQV VNSANIGNII CPDLENFKDE DNVKPEVHWY KECKPGFLED KRFVLAEGEN AVLIHNVSVQ DKGNYTCRMV YTYMGKQYNV SRTMSLVVKE SPLQMRPEFI YPKNNTIEVE LGSHVVMECN VSSGINSLIP YWEVNDGYVD DFDSTYREQF YETQRRSSCR KSLATGTKFN ISKVKEKDYA YKFFCHFIYE SQQFTSYIKL EPPAQNIQGY LIGGGVSLVF LVFVTLIIYK IFKIDIVLWY RNSCHPFLGE KASDGKIYDA YVLYPKNRES CLYSSDIFAL KILPEVLERQ CGYNLFIFGR NDLPGEAVIS IADEKIRQSR RVIVILVPEP SCYSILEDAS EKHLAMYNAL IQDGIKVILI ELEKIHDYTN MPESIKYIKQ KYGAIRWKGD FSERSHSAST RFWKKVRYHM PSRKRGSSSG FHLL // ID U3IB50_ANAPL Unreviewed; 534 AA. AC U3IB50; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSAPLP00000004472}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSAPLP00000004472}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000004472, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000004472} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000004472} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000004472} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADON01033470; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ADON01033471; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAPLT00000005088; ENSAPLP00000004472; ENSAPLG00000004919. DR GeneTree; ENSGT00760000119071; -. DR OMA; VQGTIKW; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0002113; F:interleukin-33 binding; IEA:Ensembl. DR GO; GO:0002114; F:interleukin-33 receptor activity; IEA:Ensembl. DR GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IEA:Ensembl. DR GO; GO:0090197; P:positive regulation of chemokine secretion; IEA:Ensembl. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 2. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 534 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004643404. FT TRANSMEM 330 353 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 17 109 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 112 200 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 213 320 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 375 530 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 534 AA; 62708 MW; DEF273E90B4BE2E2 CRC64; FLWFRNMVWY VHLIFLSTFL LVSVTSESYD AMEGEALVVK CPRRNSAVKV TWYHTDTKKI IPEEEEGSRI FSLGRFLWFL PNSVEDSGNY TCVTHYPNNS TKEFNMSVKV HPYKEGICFP SRILYPNNTR RGEIVCPTFD NYKNATMIQW YKDCRPLHGE RYLKKDKYIF ISDLTKEDDG YYTCHFTYTH RGNVFNVSAT RIFISEAKHL SLPAQILFPK EKDVIEVELG APLSLKCQAR LGIKKQPIDV VTWDVDNNPV IYTDTSRFHE ETHFFEGQAR EYYKEATLHI SEIKEEDLQS NFTCVVVNEM GNTRATVTLQ LKAQSDHPNV LMIVGFLVLL VIVAVSVVLY QFFRIDIVLF YREIFQPYSV KDDGKIYDAY VIYPRSYGNE ANFVEYFVHQ IMPDILENKC GYKLCIYGRD TYPGEDKASA IEKRIQKSRR LIILLTHQLL NCKEFAYDQH VALYNALIQN NTKVILLEME RMETYETLQE SLKYIIKKQG TVKWKEQHTV HPQSSNSKFW KRVRYLMPLR LRPS // ID U3IQW1_ANAPL Unreviewed; 842 AA. AC U3IQW1; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAPLP00000009634}; GN Name=TLR-15 {ECO:0000313|Ensembl:ENSAPLP00000009634}; OS Anas platyrhynchos (Mallard) (Anas boschas). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000009634, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000009634} RP NUCLEOTIDE SEQUENCE. RA Li N.; RT "The genome sequence and transcriptome of duck provide insight into RT the interaction host."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000009634} RP NUCLEOTIDE SEQUENCE. RX PubMed=23749191; DOI=10.1038/ng.2657; RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., RA Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., RA Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., RA Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J., RA Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G., RA Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M., RA Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J., RA Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J., RA Li N.; RT "The duck genome and transcriptome provide insight into an avian RT influenza virus reservoir species."; RL Nat. Genet. 45:776-783(2013). RN [3] {ECO:0000313|Ensembl:ENSAPLP00000009634} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; ADON01068471; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAPLT00000010330; ENSAPLP00000009634; ENSAPLG00000009929. DR GeneTree; ENSGT00760000119006; -. DR OMA; CDLYWFV; -. DR OrthoDB; EOG091G05L8; -. DR Proteomes; UP000016666; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016666}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 626 649 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 678 822 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 842 AA; 95671 MW; 15A505FBD87F06D6 CRC64; YFLSFLFCTS NGFLTWRTTE SAFPFYNYSY LNLSSVSEAQ APKMARALNF SHNIIEKITK RDFEGFDALE VLDLSYNQIK DIEPGTFEIL LSLVSVNLSF NDKKLLVSGL APHLKLLATS RASDKSTEAA LEPPASAEEL PHSGSPPDLQ KRRAEENTMV SPTATLRPNR CGLPINGTLD LSKSKLSEEE LTEKLDPDLC QAQLDGVLEL DISHNDLEMD LLSLFILFLP MKNVQSIDAS YNNITINNID VEAICRFPFS NLSFVNISNN PLNNLETICL PPTITVIDLS FTNISVIPQN FAKKLFNLEN MYVQGNHFIY TVHPKPNNTA PKFAPGTVHI SAISLVRNQA GTPIESLPEK VKHLKISNCS IVELPEWFAN RMQELLFLDL SSNRISMLPD LPISLQHLDI SNSDIKIIPP SFKSLPNLTV FNIQNNKVTD MHPEYFPLTL TKCDISKNKL SVLSLTKTIG KLEFLNVSRN LITRLEPTSQ LRLLTNLDGS HNLISELPDH FGKSLPMLKY FNLSGNKISF LQRGSLPVSL MELDISDNAI TTIAEDTFGQ LTSLSILTVQ GKHFFCNCDL YWFVNVYVHT PHLQINGKEN LRCSFPPDRR GSLVEGSNLT LLHCSLGIQM AITACVAVLV VLVLTGLCWR FDGLWYVKMG WYWCMAKRKQ YKKRPENKPF DAFISYSEHD ANWMKENLLV RLETDGFKIC YHERDFKPGH PVLGNIFNCI ENSHKVLFVL SPSFVNSCWC QYELYFAEHQ VLNENQDSLI MIVLEDLPPN SIPQKFSKLR KLLKRKTYLK WSPEEHKQKI FWHQLAAVLK TTNEPFIVRA ENGPTQDMYE MK // ID U3JM37_FICAL Unreviewed; 589 AA. AC U3JM37; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSFALP00000003841}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSFALP00000003841}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003841, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000003841} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23103876; DOI=10.1038/nature11584; RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., RA Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K., RA Qvarnstrom A., Uebbing S., Wolf J.B.; RT "The genomic landscape of species divergence in Ficedula RT flycatchers."; RL Nature 491:756-760(2012). RN [2] {ECO:0000313|Ensembl:ENSFALP00000003841} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGTO01010246; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSFALT00000003856; ENSFALP00000003841; ENSFALG00000003687. DR GeneTree; ENSGT00760000119071; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000016665; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 589 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004645553. FT TRANSMEM 349 372 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 23 112 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 120 210 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 245 343 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 396 551 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 589 AA; 67091 MW; 5A71FF126C2618F5 CRC64; VLTLCWILTL LISGVEVREI NLPGCSHVEP QIWYRAINGE EFVLQCALPD RDATNIYNSS LLDKHKVKWF WHQKDKETLM AIKESSNLTF QGDALWFKPI RDSASGVYIC KIWSLRGKIP CLKIVLDVQT KKAAKCSGYD TSILYLLAGS GNSITCPGTK CYSHIKKPDV KWYKDGHQIK YRKSRPSLKL KQNEIYLNPT YDKDAGIYVC DYTLPDNITK WTVRTAVTVE VTAKNTIHPP NLLYPNGVVI LEVEVGKPLE LQCRVQFGFE TVSPVRVTWK RNNEENVNEK LNQETSVCSE GLKGHTLLHV ATLKEVTEKD LRSNFTCFAE NSVGNATAVI QLKKKQRVLF LYILCSAIST LFALVLCTAF IYQHWIEIVL MYRSYLVHNK STEDGKEFDA FVSYAKLNSS ESESALISEE KFALELLPDM LENKYGYKLC ILERDILPGG AYTDDIVTAI KQSRRVIIIL SPAYVSGPSI FELQAAVNCA LEDKGIKLVL IKFLDFQEPE TLPPVVKKAL RILPVITWKS SISAAPHKKF WKYMRYYMPV KSTKRLENCS LKGLSQRLFR LPAIARSETS RRTEQAKHY // ID U3JM51_FICAL Unreviewed; 540 AA. AC U3JM51; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Interleukin 1 receptor like 1 {ECO:0000313|Ensembl:ENSFALP00000003855}; GN Name=IL1RL1 {ECO:0000313|Ensembl:ENSFALP00000003855}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003855, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000003855} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23103876; DOI=10.1038/nature11584; RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., RA Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K., RA Qvarnstrom A., Uebbing S., Wolf J.B.; RT "The genomic landscape of species divergence in Ficedula RT flycatchers."; RL Nature 491:756-760(2012). RN [2] {ECO:0000313|Ensembl:ENSFALP00000003855} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGTO01010246; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005037600.1; XM_005037543.1. DR Ensembl; ENSFALT00000003870; ENSFALP00000003855; ENSFALG00000003700. DR GeneID; 101814773; -. DR KEGG; fab:101814773; -. DR CTD; 9173; -. DR GeneTree; ENSGT00760000119071; -. DR KO; K05171; -. DR OMA; VQGTIKW; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000016665; Unplaced. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR GO; GO:0002113; F:interleukin-33 binding; IEA:Ensembl. DR GO; GO:0002114; F:interleukin-33 receptor activity; IEA:Ensembl. DR GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IEA:Ensembl. DR GO; GO:0090197; P:positive regulation of chemokine secretion; IEA:Ensembl. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 2. DR Pfam; PF13895; Ig_2; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 540 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004645550. FT DOMAIN 18 107 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 113 198 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 212 314 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 375 530 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 540 AA; 62200 MW; 3E7B29061C0314BC CRC64; MFRNMMGHID LILLSAFLSV SMTSETFDSV EGEALVIKCS KWTSAVKITW YHMDTHKIIP GEEEGSRIFS VGNLLWFLPT SREDSGNYTC VTHFSRNRTK LYNVSVQVHS YKPGGCFPSR PYYPNETERG RVTCPTIDNY ENATVVQWYK DCKPLQGQRY LKEGKYIYIE NPRREDDGYY TCQFIYAHKG NVFNVSATRI FISEVKHSPL RPEIIFPKNK DVVEAELGAA LSLKCQARLG IKKQPLAAVK WDVDNIPVES LSFSRFHEET NFFNGHDQVY YGETTLNITE VKKEDLQSNF TCISLNIMSN TRVTVTLQLK VKSEEVLPNV LLITGSLVLL GAIAVSVILY QSFRVDIVLL YREIFQPYSV KDDGKTYDAY VIYPKNHTSE ANFVEYFVYQ VMPDILENKC GYKLCIYGRD IYPGEDAASA IEKMMQKSRR LIILLTHQLI NSKEDSYDQH IALYNALIQN DTKVILLEME TIGTYGKLQE SLRFIIKQQG TIKWKEEHTA HPQSPNSKFW KQVRYHMPLT PRASHSANTR // ID U3JPF7_FICAL Unreviewed; 1047 AA. AC U3JPF7; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 28-MAR-2018, entry version 42. DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSFALP00000004661}; GN Name=TLR7 {ECO:0000313|Ensembl:ENSFALP00000004661}; OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; OC Ficedula. OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000004661, ECO:0000313|Proteomes:UP000016665}; RN [1] {ECO:0000313|Ensembl:ENSFALP00000004661} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23103876; DOI=10.1038/nature11584; RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., RA Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K., RA Qvarnstrom A., Uebbing S., Wolf J.B.; RT "The genomic landscape of species divergence in Ficedula RT flycatchers."; RL Nature 491:756-760(2012). RN [2] {ECO:0000313|Ensembl:ENSFALP00000004661} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AGTO01000469; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AGTO01010589; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005037457.1; XM_005037400.1. DR ProteinModelPortal; U3JPF7; -. DR Ensembl; ENSFALT00000004685; ENSFALP00000004661; ENSFALG00000004472. DR GeneID; 101820445; -. DR KEGG; fab:101820445; -. DR CTD; 51284; -. DR GeneTree; ENSGT00760000119006; -. DR KO; K05404; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR Proteomes; UP000016665; Unplaced. DR GO; GO:0032009; C:early phagosome; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0005768; C:endosome; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0043235; C:receptor complex; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 14. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000016665}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000016665}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1047 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004644703. FT TRANSMEM 838 862 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 887 1034 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1047 AA; 119940 MW; F8076529BDE72FFC CRC64; MVPRAKMSNA LPFILLFIFP MLLSGAWFPK TLPCDVKSSE GTVTVDCTDR RLTEVPRGIP GNATNLTLSI NHIPHIYPTT FNHLESLEEI DFRCNCVPVK LGPKDRVCSS PLKIENGSFA ALTSLRSLYL DANQLAEIPR GLPATLSLLS LEANSIFSIQ EASFSELGNI EALYLGQNCY YRNPCNVSFE IEKTAFLGLK KLTILSLKSD NLTQIPPNLS STLRELYIYN NMIQEIQEED LSGVPNLEIL DLSGNCPRCY NAPYPCIPCP KSSIQIHSKA FDSLENLRIL RLHSNSLQSI PSSWFKNMKN LQELDLSQNF LMREIGDAQF LTFIPSLVQL DLSFNFQLKM YSPYLNLSKT FSSLSNLETL RLKGYVFKEL RARDLRPLLS LRNLTMLDLG TNFIKIANLT VFEEFPALKF IDLSVNKISP SSGESNLHGF CSSPGISVER YNGQVQQEMH YFRYDLYERS CRSKDKEASS YKPLVKEDCL NYGKTLDLSR NNVFFVNPSD FQGFSSLKCL NLSGNAISQT LNGSEFSYLT GLKYLDFSNN RVDLLYQTAF KELKHLEILD LSNNQHYFLA EGVSHVLSFM KNLAHLRKLM MNENEISTTI DTGMESKSLR ILEFRGNRLD ALWMDGNARY LSFFENLTSL EELDISFNSL SFLQHGVFEK MPPSLRILNL TNNQLKSFIW GNLPSLRNLV TLDLSNNLLT NVPRELSNCT SSLQQLMLRN NRIHRLTKYF LRGAFELRYL DLSSNKIEVI KRSSFPENVI NNLKMLLLHG NPFKCNCEAV WFVWWINRTQ VTIPLLATDV TCAGPGAHKG RSVVFLDLYT CELDTSYLIL YALSASAVLG LMVFTVMSHL YFWDVWYSYH YCTAKLKGYR RLSSPDACYD AFVAYDSEDA AVNEWVLQEL VERLENQKAR QFNLCLEGRD WLPGQPVFDN LSQSIQLSKK TIFVLTKRYI KSGRFKTTFY MAHQRLLDEK MDVIILVFLE KVLQKSRYVR LRKRLCRSSV LEWPTNPQSQ PYFWQCLRNA IATSNSLAYN KLLKETV // ID U4ULX3_DENPD Unreviewed; 313 AA. AC U4ULX3; DT 11-DEC-2013, integrated into UniProtKB/TrEMBL. DT 11-DEC-2013, sequence version 1. DT 25-OCT-2017, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERL94122.1}; GN ORFNames=D910_11404 {ECO:0000313|EMBL:ERL94122.1}; OS Dendroctonus ponderosae (Mountain pine beetle). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; OC Cucujiformia; Curculionidae; Scolytinae; Dendroctonus. OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL94122.1, ECO:0000313|Proteomes:UP000030742}; RN [1] {ECO:0000313|EMBL:ERL94122.1, ECO:0000313|Proteomes:UP000030742} RP NUCLEOTIDE SEQUENCE. RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27; RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K., RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., RA Henderson H., Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., RA W Huber D.P., Birol I., Jones S.J., Bohlmann J.; RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae RT Hopkins, a major forest pest."; RL Genome Biol. 14:R27-R27(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB632380; ERL94122.1; -; Genomic_DNA. DR Proteomes; UP000030742; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030742}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000030742}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 109 129 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 93 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 154 298 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 313 AA; 35369 MW; 0632B1CA74E0E6B7 CRC64; MIPHTGDSLR LFCEAFGGTV DLPDAYNEAV WHKELADGTL IKLPKRLYQE KTLREDGQTF GTYLKFESFQ LEDAGTYVCV ISKPGVSVQK RVSIRDAAVF YIDPNPFPWK QITIACLIVS TLIMSIIVLN RKYGPKVKAL VKDNCYAIED YDGKTNDVLI AYSAEDTELA NGIMLPKLET RSYTCTSRKI TCDITRCAAE ISQYAESSRR IIVILSPAAL NDIWTSAQLY QVLKHFQTIN TCKIVYVTVR SFPVSGAEVK NNSGESLRSL MSKINIIQWN VSKDANFWFR LCRELPPKRS KYRVKSKSDG MLA // ID U5CPS8_AMBTC Unreviewed; 1015 AA. AC U5CPS8; DT 11-DEC-2013, integrated into UniProtKB/TrEMBL. DT 11-DEC-2013, sequence version 1. DT 28-MAR-2018, entry version 29. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERN15171.1}; GN ORFNames=AMTR_s00056p00146390 {ECO:0000313|EMBL:ERN15171.1}; OS Amborella trichopoda. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; OC Amborellaceae; Amborella. OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN15171.1, ECO:0000313|Proteomes:UP000017836}; RN [1] {ECO:0000313|Proteomes:UP000017836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24357323; RG Amborella Genome Project; RT "The Amborella genome and the evolution of flowering plants."; RL Science 342:1241089-1241089(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI392510; ERN15171.1; -; Genomic_DNA. DR EnsemblPlants; ERN15171; ERN15171; AMTR_s00056p00146390. DR Gramene; ERN15171; ERN15171; AMTR_s00056p00146390. DR OMA; WHGFPLR; -. DR OrthoDB; EOG09360336; -. DR Proteomes; UP000017836; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS51450; LRR; 12. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000017836}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000017836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 1 134 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1015 AA; 114653 MW; D44D0671F077E761 CRC64; MEVFLNFCDL DTGKTFTSHL KKALDVSGIS AFLPTQQQQQ LSDIQRAIEK CEVFIAVFSS NYACSSFCLD QISYLLSLSR KRTIFAVFYD VEPSHVRFQK GHFEEAFVDH RNKNGFDEET VQKWRNALKE VVSLSGWEMK NYRTEAKLIE ELVNHVSTKL DYETQLHVAD YPIGLDSRVA DVMRLLDIDA NDARMIAIHG MGGIGKTTLA KAVFNKICSS FEGRCFLSNV RESSKTNDGV VSLQKQLLQE LFNEGVPNIY SVDRGINVIK ARIGSKKVLV VIDDVDNEDQ LEKLAGNCDW YSQGSRIIIT TRDEHVLNVH KRVDSHHIYE LKVLDDTQSL ELFSWCAFKR NQPMQEYVQL SKDVTSIAGG LPLALEVLGY YLCDLTSIEE WEDAITELKR IPEDKVMLKL RISFDDLSRE TKQIFLDIAC FFIGDDKDYA IDIWKGCRFP AAGSIRKLLQ RALIKINNKN ELWMHDQLRD MGRRIVELEN LDDPGRRSRL WSEEDVTTVL KYHMGTLEVR GLMLKGNELE RSWELETFKP MTNLKLLSIS GVSLIGSFKS ISPKLVWLKL QGCPLHYLLG DLSYEELAVL DLSNNDCILE ISDIIIQQLF PKLKVLKLRC HNLQRIPRCS LYPNLEKLNL GGCCNLVEIT DSIACLGNLV YLNLEDCLNL KKLPDSLGSL AKLKELNVAQ CKELSRLPVS MGRMRSLHCL RMQQTAITTL PDDFGCLSNL KDLSMRGSKQ LKKLIESFGS LKSLRTLDIY GSSLTRLPST FSDLCSLEAL DVSYCNLKGM IPDDFEKLFS LKTLNLSGNN IKGLPSSMRG LSKLETLSIL HCKLLVAIPD LPTSLRYLNA YGCRSLQTLP KLFNLSKLEE LHFCNCEHLV AIPELPNSLK YLNASGCKSL QVLPKLSQLS ELGRLDVVDC GELSAIQELP TALETLDASN CISLQIIPNL SHLSQLKKLD LRNCKKLIEI QGLSGLISLR YLDLTGCSDH ILRGQSLAKK TPATCLLSQP FHFDC // ID U5CYD1_AMBTC Unreviewed; 1077 AA. AC U5CYD1; DT 11-DEC-2013, integrated into UniProtKB/TrEMBL. DT 11-DEC-2013, sequence version 1. DT 28-MAR-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERN15169.1}; GN ORFNames=AMTR_s00056p00145810 {ECO:0000313|EMBL:ERN15169.1}; OS Amborella trichopoda. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; OC Amborellaceae; Amborella. OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN15169.1, ECO:0000313|Proteomes:UP000017836}; RN [1] {ECO:0000313|Proteomes:UP000017836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24357323; RG Amborella Genome Project; RT "The Amborella genome and the evolution of flowering plants."; RL Science 342:1241089-1241089(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI392510; ERN15169.1; -; Genomic_DNA. DR EnsemblPlants; ERN15169; ERN15169; AMTR_s00056p00145810. DR Gramene; ERN15169; ERN15169; AMTR_s00056p00145810. DR OMA; WHAFRSS; -. DR OrthoDB; EOG09360336; -. DR Proteomes; UP000017836; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000017836}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000017836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 36 136 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1077 AA; 123531 MW; F237564685AD382B CRC64; MEVFLNFCDE DTGKSFTSHL NRVLIDSGIS TFFFPSILQQ QPRDIQRAIE KCEVFIAIFS PNYASSFFCL DQLSYFLSLP RRSRFILPVF YDVEPSHVRW QSGLFEEAFV DHRNKNGFDE ETVQKWRKAL KEFASLSRWE MKNYRTEANL VNELVKHVSA KLNYETPLHV TDYPIGLDSR VDDVLRLLDI DANDARMIGI HGMGGIGKTT LAKAVFNKIY SSFQGSCFLS DVQESSKTNV GVVSLQKQLL QELLNEGDPC ICNVDGGINV IKNRIGSKKV LVVIDDVDSE EQLEKIIGNR DWYSQGSRTI ITSRDEHVLN VRNRVDSDHI YELKGLDDAQ SLELFSWCAF QRNQPMQEYV QLSKDVTSTA GGLPLALEVL GYYLCDKRSI DEWEDATTKL KRIPEDKIML KLKVSFDDLS EETKQIFLDI VCFFIGEDKD YAIDIWKGCC FPALDSIRKL LQRLLIKIMN RNSLWMHDQL RDMGRRIVEL ENLGDPGKRS RLWSEEDVTA VLKNYMYLPG DLSYEKLVVL DLSNNDYVLE ISSSNIKQLF PKLNVLNLRC CTLWRIPNCF LYPNLEKLNL ISCCKLVEIP DPIGLLGNLV YLNLENCYNL KELPNSLGSL VNLRELNVNG CKELSRFPAS MGRMRSLLCL RMQETAIAAL PNDFGCLSNL EDLYMWNCKQ LEELPESFGS LTCLRILNIG NNINLTRLPS TFSGLCSLEI FNASDCNLQG MIPDDFEKLS SLTTLVLSGN SIQGLPRSMR GLSNLETLYI NSCKQLVAIP DLPTSLKYLS ASGCESLQTL PKLSNHSKLD YLNVRLIEIQ GLSGLMCLRE LLLSGCKPHV LRGQSLLEEM FTGLYSLSVP GSKVPNWFMC KCTSRYIRIQ DIENPDWFMY QTLSCTVSRI SEEGLHIREM MVWFVIYVNE LSCTHQKHVV NLLIKRKGRE KDRLPLGIYP GTHRNQIYIY HFRDGIGFEF QMNWLKDGDQ IEFVSESTYY EDQIEVINES GPSLTPSLGF PCYHLKQAGI HLVYESEDTE DSIEEKLADF FNSLHVQWQL TASLYVRYPF WFRIATPYFL CGIWILK // ID U5GDG4_POPTR Unreviewed; 1276 AA. AC U5GDG4; DT 11-DEC-2013, integrated into UniProtKB/TrEMBL. DT 11-DEC-2013, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERP60351.1}; GN ORFNames=POPTR_0005s03260g {ECO:0000313|EMBL:ERP60351.1}; OS Populus trichocarpa (Western balsam poplar) (Populus balsamifera OS subsp. trichocarpa). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; OC Populus. OX NCBI_TaxID=3694 {ECO:0000313|EMBL:ERP60351.1, ECO:0000313|Proteomes:UP000006729}; RN [1] {ECO:0000313|EMBL:ERP60351.1, ECO:0000313|Proteomes:UP000006729} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729}; RX PubMed=16973872; DOI=10.1126/science.1128691; RA Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I., RA Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J., RA Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., RA Boerjan W., Brun A., Brunner A., Busov V., Campbell M., Carlson J., RA Chalot M., Chapman J., Chen G.L., Cooper D., Coutinho P.M., RA Couturier J., Covert S., Cronk Q., Cunningham R., Davis J., RA Degroeve S., Dejardin A., Depamphilis C., Detter J., Dirks B., RA Dubchak I., Duplessis S., Ehlting J., Ellis B., Gendler K., RA Goodstein D., Gribskov M., Grimwood J., Groover A., Gunter L., RA Hamberger B., Heinze B., Helariutta Y., Henrissat B., Holligan D., RA Holt R., Huang W., Islam-Faridi N., Jones S., Jones-Rhoades M., RA Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J., Kelleher C., RA Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F., RA Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F., RA Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., RA Nilsson O., Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., RA Razumovskaya J., Richardson P., Rinaldi C., Ritland K., Rouze P., RA Ryaboy D., Schmutz J., Schrader J., Segerman B., Shin H., Siddiqui A., RA Sterky F., Terry A., Tsai C.J., Uberbacher E., Unneberg P., Vahala J., RA Wall K., Wessler S., Yang G., Yin T., Douglas C., Marra M., RA Sandberg G., Van de Peer Y., Rokhsar D.; RT "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray)."; RL Science 313:1596-1604(2006). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; CM000341; ERP60351.1; -; Genomic_DNA. DR RefSeq; XP_006382554.1; XM_006382492.1. DR STRING; 3694.POPTR_0005s03260.1; -. DR EnsemblPlants; POPTR_0005s03260.1; POPTR_0005s03260.1; POPTR_0005s03260. DR GeneID; 18098741; -. DR Gramene; POPTR_0005s03260.1; POPTR_0005s03260.1; POPTR_0005s03260. DR KEGG; pop:POPTR_0005s03260g; -. DR eggNOG; ENOG410J606; Eukaryota. DR eggNOG; COG4886; LUCA. DR OrthoDB; EOG093600KT; -. DR Proteomes; UP000006729; Linkage group LGV. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 8. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006729}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000006729}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 12 150 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1276 AA; 142154 MW; 8D2869BD722BC333 CRC64; MASSSSPTTP YLKHEVFLSF RGTDTRNSFT SHLYDALQRN QIDAYIDNKL DGGEKIEPAL LERIEESFIS LVIFSENYAD STFCLRELSK ILECMETKQQ MVLPVFYQLD PSHVQNLTGS YGDALCKHER DRSSEEVESW RRALKEIANL KGWDSNVIKD ETKLIQEIVS DIQKKLSHEL SLSFEEEGLV GMESRVEDIE SLLSFGSTGV LIVGIWGMGG IGKSTTADFV YRRNRSKFEG HCCFRNVREE SRKHGVDHVR QKILGDVLEK KDMTIRTIVL PPDTKRMLQR KKVLIVLDDV NDPQDLKYLL GDDDRQVLIN ACDEDKIYEV KILDEDDALR LFSLHAFKQD RPIEGYAGLS KTVVSCVKGI PLVLEVLGSS LYKKTGVEYW GSKVAQLRTN GGEEVEKCLE LCYQELRDTE KKIFLDIACF FGRCKRDHLQ QTLDLEERSG IDRLIDMCLI KIVQNKIWMH DVLVKLGKKI VHQENVDPRE RSRLWQADDI YRVLTTQRTG SKVESISLNL LAITEEMILS PTAFEGMYNL RLLKIYYPPF LKDPSKEQIM NGKRVGIRLP GGLHFLSSEL RFLYWYNYPL KSMPSNFFPK KPFQLEMPCS QLEQFWNEYQ PKLASLPDNI GELRSLVELS LSSCSKLARL ASLPDNIGAL KSLEWLHLSG CSGLASLPDS IGALKSLKSL HLSGCSGLAS LPDSIGALKS LEWLHLYGCS GLASLPNSIG ALKSLKSLHL SGCSGLASLP DTIGALKSLQ CLELSDCSGL ASLPDSIGAL KSLESLHLSG CSGLASLPDS IGALKSLEWL HLYGCSGLAS LPDSIGALKS LKSLHLSGCS GLASLPDTIG ALKSLQCLEL SDCSGLASLP DSIGALKSLE SLLLYGLASL PDTIGALKSL KSLDLKGCSG LASLPDTIGA LKSLQHLDLN GCSGLKSLPE SIGELKRLTT LDLSGCLKLA SLPNNIIDLE FKGLDKQHCY MLSGFQKVEE IASSTYKLGC HEFLNSGNSC VLKTQERLGS LVSLTQLRLS HIDFERIPAS IKQLTKLSTL YLDDCKRLQC LPELPSTLQV LIASGCISLK SVASIFMQGD REYKAVSQEF NFSECLQLDQ NSHTRIVGAA HLRIQRMATS LFYQEYHGKP LKEVRLCIPG SEVPEWFSYK NREGSLVQIQ QPAHWHRGFT LCAVVSFGQS GERRPVNIKC ECHLICKDGT QIDLSSYYYE IYEERVRSLW ERVHVFIWSV HSKCFFKEAS FQFKSPWGAT DVVVACGVHP LFVNKP // ID V3ZUI8_LOTGI Unreviewed; 583 AA. AC V3ZUI8; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 25-OCT-2017, entry version 20. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO86245.1}; GN ORFNames=LOTGIDRAFT_167288 {ECO:0000313|EMBL:ESO86245.1}; OS Lottia gigantea (Giant owl limpet). OC Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; OC Patellogastropoda; Lottioidea; Lottiidae; Lottia. OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO86245.1, ECO:0000313|Proteomes:UP000030746}; RN [1] {ECO:0000313|EMBL:ESO86245.1, ECO:0000313|Proteomes:UP000030746} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23254933; DOI=10.1038/nature11696; RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P., RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R., RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., RA Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., RA Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.; RT "Insights into bilaterian evolution from three spiralian genomes."; RL Nature 493:526-531(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KB203115; ESO86245.1; -; Genomic_DNA. DR RefSeq; XP_009063017.1; XM_009064769.1. DR EnsemblMetazoa; LotgiT167288; LotgiP167288; LotgiG167288. DR GeneID; 20240577; -. DR KEGG; lgi:LOTGIDRAFT_167288; -. DR CTD; 20240577; -. DR OrthoDB; EOG09371FJ2; -. DR Proteomes; UP000030746; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030746}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000030746}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 282 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 374 397 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 28 122 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 424 500 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 583 AA; 67229 MW; 754186E35466D17E CRC64; MVNQSVRHIH TSRNLFRSGG HPIPEKGPPF VLENQTRYLG EDAMFSCGMS FNGTISEIDH VLWLKNNEAI VNGTNHYITW EFANYSESRV KVTTNLTIYS VTEDDFGMYQ CYVTILESVK PTNDTKQKPK PKRRTENVDC SCRCVNSPSL RMPEFSKEDI QLLYYILHKF HWIGEFHLLR EKPRIRTLFI VPGTLVTVTV YFRHLREIDD FSVRFTRSGQ DIQSFDTQCS YSVRANALLL YLNGISVAYN NITYMNATEV DHWMASIGTI WTCISPSMYG VYQITILRKI YHKHDNTQWI EKIDYPTKVY IKPKESTIVT ENISNNKNRA VVVYNESCWS NEELKPESCE HINTLVESIF DKNILYENLI TRNIVILLFG AILISGIIVF FISPFMWCKI SQCYFVMKMS GKKGLAGIQV NPDLQYHLYI SSSSAPSDRS FIEQNILPII KPLDLNVFCG QEDVLPGSFE ITEISNAINK SLKCLVIATK KYIETPLQNY FEMNCILGSF SICDLVIVNV DNCLINKRFD TMYTVINCSR EGLSEKDKTV LMHWAVKGRQ IIPNVTQKSL LSKIKSCIKL FYR // ID V4LK77_EUTSA Unreviewed; 861 AA. AC V4LK77; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESQ50955.1}; GN ORFNames=EUTSA_v10022545mg {ECO:0000313|EMBL:ESQ50955.1}; OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; OC Eutrema. OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ50955.1, ECO:0000313|Proteomes:UP000030689}; RN [1] {ECO:0000313|EMBL:ESQ50955.1, ECO:0000313|Proteomes:UP000030689} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23518688; DOI=10.3389/fpls.2013.00046; RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., RA Jenkins J., Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A., RA Mitchell-Olds T., Schumaker K.S., Wang X.; RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum."; RL Front. Plant Sci. 4:46-46(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI517392; ESQ50955.1; -; Genomic_DNA. DR RefSeq; XP_006409502.1; XM_006409439.1. DR GeneID; 18025921; -. DR KEGG; eus:EUTSA_v10022545mg; -. DR Proteomes; UP000030689; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030689}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000030689}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 6 28 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 169 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 861 AA; 98073 MW; D152F1DE36FE45A4 CRC64; MDSYFFLAIV VAAISFFMLL VTIMFLFYKN SRFHQENITI ASFLSPSSPP FSFPHNQKTT SSRASTVQIE RSRSIGPELI DAIRGSKISI VLRSRNYAFS TWCMNELVEI MKCREELSQT VMTVFYEVDP TDVKKQEGDF GKVFSKTCKG KSREDIVRWS HALEEVAKIA GYHSSNWDNE AEMIEDIATD VSNKLFNSTP SRDFDGLVGI RAHMEKIEEL LQPDLDEVGM IGILGPAGIG NSTIARFLYH HHSKKFQLSV FMENIKITCQ LRACSDNYGA KLYLQEKFMS QMINHLGVKI PHLGIVEERL KDKKVLVILD DVDQLVQLES MAKEPCWFGP WSRIIITTQD QKLLRARGIN HIYRVEFPSN DEALQIFCMY AFGQKSPKDG FMDLAWECSY FKEMPEHEWS VELQRLRSRL DGKIESILKF SYDALCDEDK DLFLHIACFF NYQEVEKVVE HLAKSFFHVS VRQRLHILAE KSLIYIDEGM IEMHSLLAQL GKEIVCKQCV RDPGRRRFLV DAQDICEVLT DYTTEINLRF EESKLNISET IFEEMSNLQF LRLRNDVGPP NILFFPGCLS YISPKLRLLD WKYSLMTCLP FIGNLEFLVE LRMDHSKFEK LWDEIKPLRY LKWMDLSHSK NLKKLPNILT TPSLKELYLT NCSSLVELPS SIGNATNLRD LDLTQCSNLV ELPSSIGNAT NLRNLYLSGC SSLIELPSSI GNATNLRNLY FSGCSSLDLD LSECSSLVEL PSSIWNATKL QYLYLRQCLR LVELPSSIGK ASNLQTLDLS GCSAILPSSI GNTTNLRKLN LCGCSNLVEL PSSITNATNL QNLNLCGCSS LVGLNNLVSL ITIESNTRYN E // ID V4LWX4_EUTSA Unreviewed; 1495 AA. AC V4LWX4; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 28-FEB-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESQ55160.1}; GN ORFNames=EUTSA_v10024211mg {ECO:0000313|EMBL:ESQ55160.1}; OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; OC Eutrema. OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ55160.1, ECO:0000313|Proteomes:UP000030689}; RN [1] {ECO:0000313|EMBL:ESQ55160.1, ECO:0000313|Proteomes:UP000030689} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23518688; DOI=10.3389/fpls.2013.00046; RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., RA Jenkins J., Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A., RA Mitchell-Olds T., Schumaker K.S., Wang X.; RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum."; RL Front. Plant Sci. 4:46-46(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI517384; ESQ55160.1; -; Genomic_DNA. DR RefSeq; XP_006413707.1; XM_006413644.1. DR GeneID; 18028632; -. DR KEGG; eus:EUTSA_v10024211mg; -. DR Proteomes; UP000030689; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 4. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000030689}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030689}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 161 299 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 7 27 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1495 AA; 164758 MW; F1A5FC1FBA000337 CRC64; MRFQSFLREF KKQRRMVEKR KKRKSEELSN PVRKKIRVPS PPSLSLSSAP SSLSPSLPSS PPSPTSLSLP LLPSSLFLSS PPYSLSPSLP SSPPSPTSLS LSSLPSSLSL SSPPSSLSPS SLPSSSYLSS PPSSMSPLLP SSSSSPPSLP SPRSSSSSHN WTHDVFPSFR GEDVRRSFLS HIQKEFERKG ITPFNDNGIK RGKSIGPELI RAIRGSKIAI ILISKNYASS SWCLDELVEI MKCEEELGQT VLAIFYKVDP SDVKKLTGYF GEVFKKTCAD KSKEDIRRWR QALEKVAKIA GYHSINWDDE ANMIETIAKD VSNKLINNAP SSDFDGFVGM RAHMENMKPL LLLGSNEVRM IGIWGPSGIG KSTIARVLFW EHSSQFQFSV FMADIKRRYP RLGCSEYSTQ LQLQEEFLSS IFNQKDIKIH HLGVVQDRLK DKRVLVVLDD VDHLDQLYAV AKATGWFGPG SRIIITTQDK GLLNAHGINH VYKVGFPRYN EALEIFCMYA FGQKAPYDGF EKLAWEVTRL AGSLPLGLKV MGSYLKGRPE EEWWKELPRL RTSLDGDIES VLEFSYNALL AEDKELFLYI ACFFNNVPME KVETHLANHF PSVSQGLKVL AERSLISITT SYNGLTPEDV CMHDLLARFG REIVRRQSLY DPGQRQFLVN VQDICKVLKN DTLGSERVVG LQLDYDEIED ELIISEGSFE RMSGLQFLRT TRGDRYKHSS PNYLPRKVKL LHCGHSLMTC LPSNFNTDSL VELNMPHSKL EKLWDGIKTI KNLKWMDLSR SSNLKELPDL STATNLRVLK LQNCSGLVKL PSSIGNATKL LKLDLSGCSN LVELPSSIGN LINLTELYLS GCSNLVELLS SIGNLINLKH LDLRSCSNLV ELPSSIGNAT KLLKLDLSGC SNLVELPSSI GNLINLTELY LIDCSNLEEL PSSIGNLINL TELYLIDCSN LEELPSFIGN LINLEQLDLR SCSNLVELPS SIGNATKLLK LDLSGCSNLV ELPSSIGNAT KLLKLDLSGC SNLVELPSSI GNLINLTGLD ISGCSNLVEL PSSIGNLINL EQLDLRSCSN LVELPSSIGN LNNLEQLDLK SCSNLVELPS SIGNLINLKH LDLRSCSNLV ELPSSIGNAT KLLKLDLSGC SSLVELPSSI GNLINLAELN VSRCSSLAEL PSSIGNATKL RKLDISGCSS LLPSSIGNAT KLLKLDLSGC SSLVELPSSI GNLINLTKLD LNWCSNLVEL PSSIGNLINL KHLDLRSCSN LVELPSSIGN ATKLLILDLS GCSSLVELPY SIGDLINLTE LDLSSCSSLG CTNLVSLPEL PGSLRVLLAE NCESLETLDC SFHKIEFDRL LFSNCFKLNQ EARDLIIKTS IILPGEKVPT YFTYRNTGSS VSVNLNETDT HFPISLRFKA CILIGEQSKD TYNLMFNCRI NGVWVKMLNR VNRSLVEHLL LMELEAEVSS CELLFEFKSL SHPRCEIGGC GIRTL // ID V4MFB1_EUTSA Unreviewed; 1246 AA. AC V4MFB1; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 28-FEB-2018, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESQ55159.1}; GN ORFNames=EUTSA_v10024234mg {ECO:0000313|EMBL:ESQ55159.1}; OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; OC Eutrema. OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ55159.1, ECO:0000313|Proteomes:UP000030689}; RN [1] {ECO:0000313|EMBL:ESQ55159.1, ECO:0000313|Proteomes:UP000030689} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23518688; DOI=10.3389/fpls.2013.00046; RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., RA Jenkins J., Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A., RA Mitchell-Olds T., Schumaker K.S., Wang X.; RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum."; RL Front. Plant Sci. 4:46-46(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI517384; ESQ55159.1; -; Genomic_DNA. DR RefSeq; XP_006413706.1; XM_006413643.1. DR GeneID; 18028631; -. DR KEGG; eus:EUTSA_v10024234mg; -. DR Proteomes; UP000030689; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 4. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00367; LRR_CC; 7. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030689}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030689}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 63 201 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1246 AA; 139295 MW; E5052FA8253C17A5 CRC64; MDSSILITIL AAAIGFFMIF RKIRSHQENK EIDSSSSSLS TSSVPPSLSS PSSVPSSSSS HNWIHDVFPS FRGEDVREEF LSHIKKEFGR KGITPFNDNG IKRGESIGPE LIRAIRESKI AIVLLSKNYA SSKWCLDELV EIMKCREELG QTVMAVFYKV DPSDVKKLLG DFGKVFRKTC AGKRKEDIGR WRQALEKVAT IAGYHSNNWD DEAAMIEKIA IDVSNELINN APSSDFDGFI GMGAHMEKME PFLLLGSNEV RMIGILGPSG IGKSTIARVL YSKYSHHFQL IVFMENIKRR YPRLAYDEYS TKLQLQNEFL SQIINQEGIK IHHLGVAQDR LKDKRVLVVL DDVDHLVQLD AMAKETRWFG PGSRIIITTQ DKRLLNAHGI NHIYEVGFPH EDEALEIFCM AAFGQNSPYE GFKILAREVT GLGGRLPLGL RVMGSYLKGR SEQEWRQELP RLRTSLDGEI ESVLEFSYNA LRAEDKALFL YIACFFNNER IEKVQVHLAK NFSNVSQGLQ VLAEKSLISI SGWGSIEMHD LLARLGKEIV GRQAIHDPGE RQFLVNAQDI CQVLNNDTLG SKRVIGIDLK YHEIKDELKI SERAFERMSS LQFLRTRGDS NYALQPRPNY LPPKVTLLHC EYFPMTCLPS RFNPNFLVEL NMPRSRLEKL WKGIKTIKNL KWMDLSYSEN LKELPDLSTA SSLQELKLKY CSSLVKLPSS IGNAVNLQKL DLSKCSSLVK LPSSIGNAVN LQKLNLSRCS SLVEVSSSIG YVINLKKLNL CGCSSIVNLP FSIGNVTSLQ RLDLSGCLSL VELPSSIRNL INLQKLDLSD CSSLVELPSS IWNVFNSNLK ELNLRDCSSV VKLPSFIVNV VNLEKLNISG CSSLVKLSSS MGNAVNLNEL NLSGCSSIVK LPFSIGNVTN LQELNLKGCS SLVELPFSIG NLINLTELDL SGCSSLAELP SSIGNAVNLQ KLDLNGCSSL VELPSSIENL RNLLYLPLKG CSKLEALPIN INMESLHKLD LTDCSSLKSH CIILSTCKCN TGMYRLHTLV LERCTNLVSL PELPGSLRVL LAENCESLET LDCSFHKTEF DRLRFINCFK LNQDAIDLII KTSIGHYGHA VLPGEKVPTY FTYRNNGSSI SVNLNETDTH FPISLRFKAC VLLVNKGGNW SLRYLYCRIN GVNSRIPILT ELSPCGKEHL FIFEYEAQVS SSELVFEFEF SEKKLEIGEC GIQTSVEAED EVSRED // ID V4NC85_EUTSA Unreviewed; 1104 AA. AC V4NC85; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 28-FEB-2018, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESQ43551.1}; DE Flags: Fragment; GN ORFNames=EUTSA_v10015416mg {ECO:0000313|EMBL:ESQ43551.1}; OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; OC Eutrema. OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ43551.1, ECO:0000313|Proteomes:UP000030689}; RN [1] {ECO:0000313|EMBL:ESQ43551.1, ECO:0000313|Proteomes:UP000030689} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23518688; DOI=10.3389/fpls.2013.00046; RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., RA Jenkins J., Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A., RA Mitchell-Olds T., Schumaker K.S., Wang X.; RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum."; RL Front. Plant Sci. 4:46-46(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI517464; ESQ43551.1; -; Genomic_DNA. DR RefSeq; XP_006402098.1; XM_006402035.1. DR GeneID; 18018394; -. DR KEGG; eus:EUTSA_v10015416mg; -. DR Proteomes; UP000030689; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR011713; Leu-rich_rpt_3. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 2. DR Pfam; PF07725; LRR_3; 1. DR Pfam; PF00931; NB-ARC; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030689}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030689}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 1 136 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1104 1104 {ECO:0000313|EMBL:ESQ43551.1}. SQ SEQUENCE 1104 AA; 125109 MW; D23C0EC03ECA4FEA CRC64; MEGNTKVRLT MMIHVVRKLK GMFKSKGITP FIDNEIKRGQ SIGPELILAI RESRVAIVLL SSNYASSSWC LDELVEIIKC KEENQQTVMT IFYDVDPSDV RKQTGDVGKA FEKTCVGKTK EVKQRWSQAL KDVASIAVES SFFFLDNEAD LINKIASDVM GVLDFTPSRD FDDFVGIEAR ITEINSLLSL QSDEVKMLGI LGPAGIGKTT TARVLYDQLS CDFQYSAFME NIKASYARPC YDDYQLKLCF QKQLLSQIVN QKDIEVRHLG VAQEKLRDKK VLVVLDEVFK AHGINHIYEM TYPTSDEALQ IFCQYAFGQN SPYDGFEGLA WEVTKLAGEL PLGLRVLGSY LRGMSIDEWI DALPRLRSSL DKEIESVLRF SYDALGDKDK ALFLYIACFF ALDWDYFDSY SVERIKRFLA NSDLDVNHGL QLLAQKSLIC IDDGTLDIHP LLQQMGREIV YKQSFEPGKR QFLMDSTEIC DLLKENTGTG TVLGIFFQPP DREEIYLSEK AFDGMNNLQL LTVYSSSVCL PEGLNCLPNK LRFLNWDYFP MRFWPSEFSS EFLVELIMCQ SKLEKLWEGI KVTAPMSQAM KLSHSEDLKE IPDLSKATNL EVLDLSGCSG FLELTNSIGN ATKLKRLNLG GCCLLKELPF SIGNAMSIQY LDLYYCTSLE KLPSSIVASM SGCKNIETFP TNINMKSLSE ISLGGCTRLK MFPDISRRIK KLDLRDTAIE EVPSSISSWY SLYSLDMSGC RNLKEFPYVP DTIVGLELSE TRIKEVPPRI ENLFRLCKLI MYGCKKLNNI SPKISKLENL QFLGLKDGEG GKDAVDGDGE DDEVINWGHS KPSWTLRTDF NVHYILPICL PEKALTSPIS LCFRGNGLKT IPNCVRRLSE LSKLDIRECR KLVALPQLPD SYYSFPNSKI CLNFANCINL NQEARELIQR SACQYAFLPG VEVPAHLTHQ ATSHSLTINL SPRPLPSLFT FRACIILSTR NCNLEDHTEE DEEDETSLRH VSCHVKGKQD GFTVRYKSIH LPIPAKLGDI EHQYICKDSS FRTQVCPEAN EDTFSELVFE FIVHDKTWEV RACGVQILDT HHHILDENKT EEKE // ID V4T462_9ROSI Unreviewed; 980 AA. AC V4T462; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 28-FEB-2018, entry version 21. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESR55003.1}; GN ORFNames=CICLE_v10023653mg {ECO:0000313|EMBL:ESR55003.1}; OS Citrus clementina. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; OC Citrus. OX NCBI_TaxID=85681 {ECO:0000313|EMBL:ESR55003.1, ECO:0000313|Proteomes:UP000030687}; RN [1] {ECO:0000313|EMBL:ESR55003.1, ECO:0000313|Proteomes:UP000030687} RP NUCLEOTIDE SEQUENCE. RG International Citrus Genome Consortium; RA Jenkins J., Schmutz J., Prochnik S., Rokhsar D., Gmitter F., RA Ollitrault P., Machado M., Talon M., Wincker P., Jaillon O., RA Morgante M.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI536661; ESR55003.1; -; Genomic_DNA. DR RefSeq; XP_006441763.1; XM_006441700.1. DR GeneID; 18050039; -. DR KEGG; cic:CICLE_v10023653mg; -. DR Proteomes; UP000030687; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030687}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030687}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 2 77 TIR. {ECO:0000259|Pfam:PF01582}. FT DOMAIN 102 344 NB-ARC. {ECO:0000259|Pfam:PF00931}. SQ SEQUENCE 980 AA; 111654 MW; DC049BC76004AF2C CRC64; MVYPIFYDVE PTDVRKQSGI LEAVFARHEE ILAQNKEKVQ KWRDTLKEVA NICGWELKDR NQSEFILEVV KVISSKSPII SGILKNLVGI DSHLKNLRLL MDKGSNYVRM IGICGMGGIG KTTLARVVYD LTSHKFEGSS FLANVREISK EGGLISLQKQ LLSQLLKLPN NGIWNVYDGI NIIGSRLHHK KVLLLIDDVV DIKQLECLAG KREWFGPGSR IIITSRDKHL LMTHGVDEVY KLRELHDDNA LQLFCKKAFK THQPKKGYEQ LSEWVTKYSG GLPLALKVLG SFLYGKTTKE WQSAVKRLKR DSENEILDIL QISFDGLKET EKKIFLDIAC FHRGENRDYV TKILDYCDFD PVIGIRVLID KSLIEVLSNN QLWMHDFLRE MGQQIVKRQC PEDPGKRSRL WKEADVRQLL TRNTGSETVE VIYLNFPAEA EVHFRASSNT FLKMTNLRML LIRNVQVQLP EGLEYLSNEL RLLEWPGYPL KSLPSNFQPD KIVELNMCYS HIEQMWNGIK PLSNLKFMRL GKSKNLIRTP DFSGMPCLEE LDLGGCTRLC DIHPTLLLHK KVTLLNLKDC TSLTTLPGKI FMESLKILVL SGCLKLKNFP EIVGKIMTNM EHVLELHLEG TAIRGLPISI ELFSGLVLLN LRDCKNLLSL PCTINGLKSL KKLYLSGCSK LKNVPENLGK VESLEVLELS GCKGPPVSSS WYLPSPISLK RSCSDPTALR LPSLSGLWSL RKLDLSDCDL GEGAIPNDIG NLWSLEELYL SKNSFVTAPA SINRLFNLEE LELEDCKRLQ SMPQLPPNIK EVGAVSRPMQ KFGIVVPGSE IPEWFMHQND GSSIKFIMPS NLYCKNKALG YAVCCVFHVR EHSPGIQTRR SYPTHQLNCQ MKGSSTSYSI EFREKFAEAE SGHLWLLYLS LKKCYYSNWR FDNNLIELSF RPVSGSGLQV KRCGFHPIYR HKVEFFNQIR NQWTHSLHCL // ID V4VPQ2_9ROSI Unreviewed; 1097 AA. AC V4VPQ2; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 28-FEB-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESR54924.1}; DE Flags: Fragment; GN ORFNames=CICLE_v10024297mg {ECO:0000313|EMBL:ESR54924.1}; OS Citrus clementina. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; OC Citrus. OX NCBI_TaxID=85681 {ECO:0000313|EMBL:ESR54924.1, ECO:0000313|Proteomes:UP000030687}; RN [1] {ECO:0000313|EMBL:ESR54924.1, ECO:0000313|Proteomes:UP000030687} RP NUCLEOTIDE SEQUENCE. RG International Citrus Genome Consortium; RA Jenkins J., Schmutz J., Prochnik S., Rokhsar D., Gmitter F., RA Ollitrault P., Machado M., Talon M., Wincker P., Jaillon O., RA Morgante M.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI536661; ESR54924.1; -; Genomic_DNA. DR RefSeq; XP_006441684.1; XM_006441621.1. DR GeneID; 18045948; -. DR KEGG; cic:CICLE_v10024297mg; -. DR Proteomes; UP000030687; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 4. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000030687}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000030687}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 12 152 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1097 1097 {ECO:0000313|EMBL:ESR54924.1}. SQ SEQUENCE 1097 AA; 123339 MW; 1026E7A19F7F573D CRC64; MAFTSIQTIS YGKYDAFLSF RGEDARKSFT GHLYTALKNK GIYAFRDDKE LQKGGSISPE LLKAIEESRV SIIVLSKNYA SSTWCLDELA KIVECKNKED QIFPIFYDVE PTVVRKQTAN FGKAFAKHEE NFKDNIEKVQ KWRDALKVVA NKSGWELKDS NESEFIEEIV NVISSKIRTK PETAKGLVGI ESRLEKLMFL MGTGSIDVRM IGIWGMGGLG KTTLARVAYD LMSHEFDGSS FLADVREKSE KEGSVISLQK QLLSDLLKLA DNSIRNVHDG INMIGSRLRQ KKVLLVIDDV ANVEQLQRLA GKRDWFGPGS RIIITTRDEH LLKLHRVEEV FKLEALSYYK AFELFCLKAF ETQKPREEYV HLSQLVVKYA SGLPLALKVL GSFLFGRPVD EWTSTLERLK REPENEILDI LQISFDGLKE AEKEIFLDVA CFFKGEKRDY VSKILNSCGF EPVIGISVLI EQSLLTVCED DKLWMHDLLQ EMGRQIVRRQ SPEEPGKRSR LWEEADVCHV LSQNTGSEVV EGIIVDDYYF LKDKVHLSAG PKAFSKMTNL RLLKICNLQL PQGLEYLSNK LRLLDWHQYP WKSLPSDLQL DKIVEFKMSP FCFQQPLNVL KVMKLSHSKN LIKTPDFTEV PNLEELDLEG CTRLREIHPS LLLHNKLILL NLKGCTSLIT LPGKIFMKSL KTLVLSSCLK LKKFPCVAGG MKCLQDLLLN ETDIKELPLS IELLSGLVQL TLKGCKNLSS LPVTISSLKC LRNLELSGCS KLKTFPEIVA SMEDLSELYL DGTSITEVPP SIELLMGLEL LNLNDCKNLV RLPNSIKGLK SLKTLNLSGC FKLENVPETV GQVESLEELD ISGTAIRQPP SSIFLMKNLR TLSFSECNGP PSSTSWHFHF PFNLMAKSSY PVPLMLPSLS GLCSLTKLDL RDCSLGEGVI PNDIGNLCSL KALYLSKNSF VRLPASIDGL FNLEELELED CKSLQSLPQL PPNVKRVNVN GCTSLVTLLG ALKLCKSEYT LIDCVDSLKF PGNNGLAFSM LQEYLEVSLL ATPKLCLKKL SNGMDSFIFL IFWLQAVSGP LKDFSIVVPG SEIPKWF // ID V8NJV6_OPHHA Unreviewed; 459 AA. AC V8NJV6; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 17. DE SubName: Full=Interleukin-1 receptor-like 2 {ECO:0000313|EMBL:ETE61938.1}; DE Flags: Fragment; GN Name=Il1rl2 {ECO:0000313|EMBL:ETE61938.1}; GN ORFNames=L345_12310 {ECO:0000313|EMBL:ETE61938.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE61938.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE61938.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE61938.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE61938.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AZIM01003565; ETE61938.1; -; Genomic_DNA. DR ProteinModelPortal; V8NJV6; -. DR Proteomes; UP000018936; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 2. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 2. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ETE61938.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 233 256 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 13 116 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 131 211 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 279 436 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE61938.1}. FT NON_TER 459 459 {ECO:0000313|EMBL:ETE61938.1}. SQ SEQUENCE 459 AA; 52357 MW; A8F8CA816E2FD2A7 CRC64; VLPDGRRVTS ALPKVTARQI QGEEAIVSFY PKGEPGTVSC LSGSQSNHVV TWYRKDIEMP ITTDNSSREC HLHLYEDRKF SSSGEQLLIN NVSKEDEGIY ICRAKHIYQG KEYNISRAIK LITFEAPKTY PDIIYPNNNS IEVKPGSRFD LVCNVSADPL DKMVIVTWTF DNEILNTNEK VQVLSGKQII EVKLNISKVK DRDYGKYLCE VWSGRVIQVA YVMLNYPAPN IQIYVIGGLI SPLFIIVASL LTYKFFKVDI VLWYRDSCQH LSKGISDEKV YDAYVLYPHN VSGSVYLTET FVFKLLPEIL EKQCGYKLFI LGRDDVPGQA VITIVDKMIK LSRRVIIILM PDLYCGGRQS LFSEQELAVY SALIQEETKV ILIQLDKIKD FNSIPESLRY LKQKHGILTW RGTFTETTEM ATTRFWKNVR YQMPASPSPL SSNLHFLPIT FHSSQISDG // ID V8NVI8_OPHHA Unreviewed; 546 AA. AC V8NVI8; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 28-FEB-2018, entry version 24. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:ETE66264.1}; DE Flags: Fragment; GN Name=TLR7 {ECO:0000313|EMBL:ETE66264.1}; GN ORFNames=L345_07960 {ECO:0000313|EMBL:ETE66264.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE66264.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE66264.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE66264.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE66264.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AZIM01001611; ETE66264.1; -; Genomic_DNA. DR Proteomes; UP000018936; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 2. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 3. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 7. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Receptor {ECO:0000313|EMBL:ETE66264.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 445 546 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE66264.1}. SQ SEQUENCE 546 AA; 62627 MW; 840B73A836FDD911 CRC64; MYMQVDCSDR KLIEFPKDIP ANVTNLTLAV NHISQISKSH FKNLKNLLEI DFKCNCVPIR LGPKDHVCTQ GLKIQAHAFS KLFSLKSLYL DGNQLSAIPQ HLPPNLRLLS LEANSIFSVK KENLSGLENL EVLQLGQNCY YRNPCNITFE INGTAFQPLT NLKVLSLKAN NLSKVPQNLP STLRELYLYN NAIRNIAEHD LSSLNNLEVL DLSGNCPRCH NARYHCTECP GSILINPKAF DSLKHLKVLR LHSTSLKQVD HHWFKNTKNL QQLSDLKCLN ISNNAMSQAF KGTEFTHLSS LKCLDLSNNR IDLLHVKAFQ QLKELEVLNL SDNSYYFKAE GVTHMLGFTK YLINLKILIM SGNEISVSTD KGMESDSIKI LEFRRNRLDI LWKDGTIEYL AFFKNLTTLE SLDISENFLT SLPPDVFYNL PPKLKGYKRL FSSEVKYDAF VAYDNKDEAV TEWILKELIE KLEDQKEKKF NICLEERDWL PGHPLMENLN DSIHTSRKTI FVLTNSYIAS GNFRIAFYMA HQRLLDEKVD TVLLCF // ID V8PAS8_OPHHA Unreviewed; 444 AA. AC V8PAS8; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|EMBL:ETE71103.1}; DE Flags: Fragment; GN Name=IL1RAPL2 {ECO:0000313|EMBL:ETE71103.1}; GN ORFNames=L345_03082 {ECO:0000313|EMBL:ETE71103.1}; OS Ophiophagus hannah (King cobra) (Naja hannah). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71103.1, ECO:0000313|Proteomes:UP000018936}; RN [1] {ECO:0000313|EMBL:ETE71103.1, ECO:0000313|Proteomes:UP000018936} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ETE71103.1}; RX PubMed=24297900; DOI=10.1073/pnas.1314702110; RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J., RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J., RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A., RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C., RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M., RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., RA Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M., RA Richardson M.K.; RT "The king cobra genome reveals dynamic gene evolution and adaptation RT in the snake venom system."; RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013). CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:ETE71103.1}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AZIM01000431; ETE71103.1; -; Genomic_DNA. DR Proteomes; UP000018936; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018936}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ETE71103.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000018936}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 444 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004771406. FT TRANSMEM 114 132 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 15 104 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 157 316 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 1 1 {ECO:0000313|EMBL:ETE71103.1}. SQ SEQUENCE 444 AA; 51033 MW; 3CA970D7BED39195 CRC64; HHYHFLFTLL CCFPGQPLNV VCKAFFGFSG ESGPMIYWTR GEKFIEELES HIKEGEIRLL KEHLGEKIVE LTLIFDIVKE ADLANYTCHV ENRNGKKQAS IILRKRDLIS RIELAGGLGA IFLLLVLLVT IYKCYNIELM LCYRQMFGGD EAMDDNKEYD AYLSYTKVDP DTLDRDNREE EQFVLEILPD VLEKQYGYKL FIPDRDLIPT GTYLEDLARC IEQSRRLLIV LTPDYVLRRG WSIFEMENRL HNMLLGGEIK VIFIECPQLR GKVNYQEVES LKHSIKLFSV VPWKGPQSNK PNSKFWKHLL YEMPAKKKEV ISRRQVLDSA EQGLFADLQT VPSIAVTDTP ATLISSQADL GDYPPANTAQ MRHYCRGYDY NVQSATLPLA AISSNHHTYC NIPLTLLNGQ LPLNSSVKDV QDFHRNPSLL PLSTRELSFT SDIW // ID W1NGT2_AMBTC Unreviewed; 1140 AA. AC W1NGT2; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 28-FEB-2018, entry version 24. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERM94380.1}; GN ORFNames=AMTR_s00010p00250780 {ECO:0000313|EMBL:ERM94380.1}; OS Amborella trichopoda. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; OC Amborellaceae; Amborella. OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERM94380.1, ECO:0000313|Proteomes:UP000017836}; RN [1] {ECO:0000313|Proteomes:UP000017836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24357323; RG Amborella Genome Project; RT "The Amborella genome and the evolution of flowering plants."; RL Science 342:1241089-1241089(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI397513; ERM94380.1; -; Genomic_DNA. DR EnsemblPlants; ERM94380; ERM94380; AMTR_s00010p00250780. DR Gramene; ERM94380; ERM94380; AMTR_s00010p00250780. DR OrthoDB; EOG093600UI; -. DR Proteomes; UP000017836; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 3. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000017836}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000017836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 79 165 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1140 AA; 130328 MW; AB474CD9B9EE6E27 CRC64; MPRISSSRAQ KLFSCWFRPD TSIMEVNKSN VDLRKCEIFI CHSPSLEVQN GIAKDLLSHL QKLNISTLCS RDCSIPNEEA INEATVCIVI LSRDFANCTL CLEELRLMHQ SKVHMIPIFY DVRPSEVRRT EKGVYRPAFE EAEKSMQKEE WKFFLQKTGY LSGWKFSDFR GNSRKLLKAV VQDAINMVNA NVLEVARHPV GLAEKTEKLQ RLLEVGREGT GARVLGLVGM GGIGKTTLAK EFFSIMRSQF KAFSFVDDIK DRVVRAGLEK VQGFLLKDLL QIDHQIHSIN QGKFLLRKCL SRAEVIIVLD NIDDFDQLDA LRVPEVVHCT SIVLITTRDR RLVECIPNAL IYDMDGLEKH HAKELFCWHA FLMPQPALGF DVLVDNFVTY CNGLPLSLET LGAQVFGETI HIWERILQTI VEIIPGDIDR HLRVSYDALD WSEKQIFLDI ASFFIGENKD MAIKVWDAFK WFGSVGVQSL QQKCLVKLEK NKFRMHDQLR DMAAKILEEE DFNNPGRRSR LWRPNDVIKV LDEESGSETV QGLTLIVNAV EDDRSHSFVV PKSKVIRKKG GPLVWSLSSF APMTELQLLI LEDACIEGDF SFLSRKLVWL RWRHSPSVSF PVGLPLTNLH ILDMSGGKFA HLWNDDQEIP VKLQELNLRG CVYLQGFPKS VKLLTRLEKL VLNHCLNLVA ISDEFCYIQA LKYLDLSGCE NMQALPDNIG NLRNLQYLDL SHCERLDYLP PTIGDLLKLE HLDLNGCRAL LEIPESFQKL TEIRYLDLEH CWKLRVEKDI IGGFKKLEVC RAFSCKTFYF PSVISCQRCI RELLVSCSQF TELPDYFGEL TSLEELCLWN GHEVRAFPTT LFTKLTQLKK LTIGFFKLLE DLGSSIKHLR KLTSFSILSC RIRRLPMEMS DLKNMEFLLV HNCRKLMKLP VGNISGLVTL SLSGTPQLKL DPEAFPDLSA IKKLHIDECV ISDGFLKFIF EGFPSLEELE LKNLRLPNML GIGKYPANLQ SVSILSCSNI KEFEIVGAFK SLQIKDCPGL KKIIASKLSM KLQTLYLGHC KHLVDVCSIE NLHSLEYLNF EGCFDLQSIE NLEKLNKLTE FHLFLSDKYL VESSNQEKEK VDWLQVSITG DASYRLFICS // ID W1NL71_AMBTC Unreviewed; 1366 AA. AC W1NL71; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 28-FEB-2018, entry version 26. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERM95965.1}; GN ORFNames=AMTR_s00060p00214220 {ECO:0000313|EMBL:ERM95965.1}; OS Amborella trichopoda. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; OC Amborellaceae; Amborella. OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERM95965.1, ECO:0000313|Proteomes:UP000017836}; RN [1] {ECO:0000313|Proteomes:UP000017836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24357323; RG Amborella Genome Project; RT "The Amborella genome and the evolution of flowering plants."; RL Science 342:1241089-1241089(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI397373; ERM95965.1; -; Genomic_DNA. DR EnsemblPlants; ERM95965; ERM95965; AMTR_s00060p00214220. DR Gramene; ERM95965; ERM95965; AMTR_s00060p00214220. DR OrthoDB; EOG093600UI; -. DR Proteomes; UP000017836; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000017836}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000017836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 79 165 TIR. {ECO:0000259|PROSITE:PS50104}. FT COILED 1302 1329 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1366 AA; 155821 MW; 9F89F5CFD577A895 CRC64; MPRSSSSRVQ KLFSRWFRPD TSTMEVNTCN VDSRKCEIFI CHSPSLEVQN GIAKDLLLHL QKLNISTLCS RNCSIPNEEV INEATVCIVI LTRDFANCTL CLEELRLMHQ SKIHMIPIFY DVRPSEVRRT EKGVFRLAFE GAEKSMQKEE WKFFLQKTGY LSGWKFSDFR WNSRKLLKAV VQDAIKMVNA NVLEVAKHPV GLAEKTEKLQ RLLEVGREGR GARVLGLVGM GGIGKTTLAK EFFNIMRSQF KASCFVDDIK DRVVRAGLEK VQGFLLKDLL QIDNQIHSIN QGKFLLRKCL VRAEVIIVLD NIDDFDQLDA LQVPEVVHCT SIVLITTRDR RLVECIPNVL IYDMDGLEKH YAKELFCWHA FLMPQPALGF DVLVDKFVTY CNGLPLSLET LGAQVFGETI HIWERILQTI VEIIPGDIDR HLRVSYDALD WSEKQIFLDI ASFFIGEDKD MAIRVWDALK WFGSAGVRSL QHKCLVKLEK NKFRMHDQLR DMAAKILEEE NFNNPGCRSR LWRPNDVIKV LDEGSGSETV QGLTLVVNAV EDDGIHSFVV PKSKVIRKKG GHLPWSLSSF APMTELQLLI LEDACIEGDF SFLSRKLLCF RWRHSPSESF PVGLPVTNLH VLDMSGGKFS HLWSDIQEIP VQLQELNLRG CLYLQGFPKS IKLLTRLEKL VLSHCLSLVA ISDEFCDIQA LKYLDLSGCE NMQALPDNIG NLRNLQYLDL SDCERLEYLP PTIGDLLKLE HLDLKGCTAL LEIPESFKKL TEIRYLDFEQ CCKLQVEKDI IGGFQKLEFF RALSCKTFYF PSVISCQRCI RKLWVSCSQF TELPEYFGEL TSLEELRLWN GHGVRAFPTT LFTKLTQLKK LTIGLFTLLE DLGSSVKHLR KLTLFSILSC RIHCLPMEMS DLKNMEFLFI HNCRKLMKLP VGSLSGLVTL SLSGTPQLKL DPEAFPELSA IKKLCIDECV ITDGFLKFVF EGFPSLEELE LGNLRLPNML GIGKYPANLQ SVSISSCTNI KEFEIVGAFK SLRIKDCPGL RKIIASKFST KLQTLYLGHC KHLVDVCSIE NLHNLEYLNF EGCFDLESIE NLEKLNKLTE FHLFLSDKYL VGGTNQEKKK VLMKGTDWLQ KFIGNKQPQA THLSAEVNLL TSNLDIHPYF QQIFAHSSSE FKFRLPPTRS MMGTVMICFI CQHSKSKNIL IGPSGGMKSV LYRPIDLHLV NGANKNQISQ YRVYDSGTFL HIGIFTEEYM VMEMLAEESE LVLSAGSSDL IYGAWACLLP VSEKHLVGEI ISRQINMLKV HKKNDKNYVE REEVEKKKLK DEVQDLMFDM DLHNVYALDI ANFIVQRTYM LCNTSIYVSL HGFAST // ID W1NN18_AMBTC Unreviewed; 1242 AA. AC W1NN18; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERM96709.1}; GN ORFNames=AMTR_s00001p00273020 {ECO:0000313|EMBL:ERM96709.1}; OS Amborella trichopoda. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; OC Amborellaceae; Amborella. OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERM96709.1, ECO:0000313|Proteomes:UP000017836}; RN [1] {ECO:0000313|Proteomes:UP000017836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24357323; RG Amborella Genome Project; RT "The Amborella genome and the evolution of flowering plants."; RL Science 342:1241089-1241089(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI397142; ERM96709.1; -; Genomic_DNA. DR RefSeq; XP_006829293.1; XM_006829230.1. DR EnsemblPlants; ERM96709; ERM96709; AMTR_s00001p00273020. DR GeneID; 18424646; -. DR Gramene; ERM96709; ERM96709; AMTR_s00001p00273020. DR KEGG; atr:18424646; -. DR OMA; WNDDVER; -. DR OrthoDB; EOG093600KT; -. DR Proteomes; UP000017836; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 2. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 2. DR SMART; SM00369; LRR_TYP; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000017836}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000017836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 42 136 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1242 AA; 142264 MW; 171F6F2BE81AEE85 CRC64; MAVFLNFCDE DTGKSFVAHL NNALTESGIS TFFFSQRGQG EEEMERAIRE CEVLIAVFST NYASSSLCLN QLSYLMSLPA TSMKSILPVF YDVEPFHVRR QEGPFKGALE FHKKKNGSDE EIILNWRNAF QQVADLFCWD MQNHSYASFS FPLDQLSYFL NLPPKWGRRS IFPVFFYVEP SRFCRQQRPF SGAFEFHKKK TEIGEETVQN WRNALKEVGG LCGWDMKNCR NEANLVQELV EHASAKLENT TSWHVADHPI GLDSRVDDVM TLLDVDAADV RMIGIHGMGG IGKTTLAKAV FNKIYASFDA KCFLSDIREV SRTCGGLVTL QKHLLKELFS DEGRNIYDVD RGINVIKKRI GSKKVLVVFD DIDDEIQLEK LAGNHHWYCQ GSRIIITTRD EHVLNVHKRV ENNHIYKLEG LADTQSLELF SWCAFQRNQP MQEYVQLSRD VVSTAGGLPL ALEVLGYYLC DKTIEEWKDA ITKLKRIPED KVLLKLKISF DDLSEETKQI FLDIACFFIG QDKDYTIYIW KGSGFPALNS IRKLLQRALI KITNENCLWM HDQLRDVGRR IVELENLGDP GRCSRLWSRE DVIDVLKNHK GTREVRGLML KGNEREENWE TEAFKPMTNL KLLNISDVSL KGSFKSLSSE LVWLKWLRCP LKYVPDDFSY EKLAVLDLSD SEAVWNLLNN NIKQIFPKLK VLILRGCHNL ERIPNCSLYP NLETLNLEQC CNLVEIPNSI GLLRNLVYLN LCECSSLKEV PDSLGSLENL KELDVGQCEE LSRFPTSIGR MRSLRYLYMK NTALATLPDD FGRLSKLEEL TMNWCKQLKE LPESFGNLTS LRALNISNST SLTRLPSTFS SLCSLEKLNA EDCNLQGMIP DDFEKLSSLR ILNLTRNKVQ GLPSSMRCLS HLEELYINGC EQLVAIPELP TSLKHLDASG CKSLQMITKL SHLYHLETLC IYDCEQLVAI PELPHSLKEF KARGCSSLQT MPKLFHLSKL KELDVNDCKK LSAIEDIPTN LELLFASNCI SLQIIPNLFH LSQLKHLDLT NCEKVIEIQG LNGLKSLREL FLSGCSPHTL RGQSLAKETF TSLDKLSIPG SKVPDWFMFQ TPSFTVPRLS DVGLHIREVL LCFSYSTYDT SPGSPRSMVS IKREDRGIRI EEQVDIQYFP LSHQNQVFFR RLRHGHMPRL WFKWFKDENQ IELLTKFMVC LKGAMHLVYK PADTDESIQE RLANFFNPLL SE // ID W1PVE6_AMBTC Unreviewed; 1153 AA. AC W1PVE6; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 28-MAR-2018, entry version 27. DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERN11255.1}; GN ORFNames=AMTR_s00024p00233110 {ECO:0000313|EMBL:ERN11255.1}; OS Amborella trichopoda. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; OC Amborellaceae; Amborella. OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN11255.1, ECO:0000313|Proteomes:UP000017836}; RN [1] {ECO:0000313|Proteomes:UP000017836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24357323; RG Amborella Genome Project; RT "The Amborella genome and the evolution of flowering plants."; RL Science 342:1241089-1241089(2013). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; KI392710; ERN11255.1; -; Genomic_DNA. DR EnsemblPlants; ERN11255; ERN11255; AMTR_s00024p00233110. DR Gramene; ERN11255; ERN11255; AMTR_s00024p00233110. DR OMA; MVHLDMS; -. DR OrthoDB; EOG0936057E; -. DR Proteomes; UP000017836; Unassembled WGS sequence. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000017836}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Reference proteome {ECO:0000313|Proteomes:UP000017836}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 1 140 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1153 AA; 130601 MW; D4E5BF57338E1E4A CRC64; MPVFLNFCYE DTGKSFTAHL NRVLNESGFS TFFSPTEQNQ AISNLAGEIQ RAIEECEVFI TILSYNYASS VSCLEELSFR VSLRAVRSSV VPVFYGVEPS DARFQTGSFE GALEDQKKQN GLDEERVQRW KNALKHVADR SGRDMKNYRS EANLVHEIVK VVADKLNYMA PLHVADHLIG LDSRVDDVER LLDVSADGGV RMIGIHGMGG IGKTTLAKAI FNKIRSSFQC SCFLSDIREA SRTHYGLVNL LKQLLKDLFN EEDPNISDAD RGVSVFKNRI RSKKVLVILD DVDHQKQLEK LAGKHDWYCR GSRIITTTRD EHVLNVSNRV DRHHVYKLKE LDYTQSLQLF SWWAFGRDQP TQEYAKLSKD VVSTAGGLPL ALEVLGSSLW DKTTIEEWEE TVEMLRNVPE NDVILKLKVS FDYLIEEEKQ IFLDIACFFI GMDRDYAVTI WKGCGLPASI SIKRLSQRSL IKIDDENRLW MHDQLRDMGR RIVKLENLDD PGSRSRLWDQ DEVFDVLKNH KGSGKVRGLI LSVNNQGQSW KTEAFKPMSS LKLLSISFAS LNGSFRSLPS GLVWLKWKKC PLQYLPDDFP YEKLAVLDLS NSLSELVWKN MLIPNLKVLD LRYCVKLNRI PNCSQYQNLE KLNLSNCWEL VEIPNSISLL ENLIYLNVNR CHLKELPSTI SGLQSLQKLI ISNNHGLDKL PEQLFSMKSL TELDMTSSGI QQLPDSIGNL KNLRILRLGF TNVRELPDSL GSLVNLEELD VNRCNIRELP DSLGTLVNLE KLNVNRCKIL SRFPASMGRM RSLLYLNMVE TATATLPHDF GLLSKLDKLN TIGCRQLKEL PESFGSLTSL RTLEMNNNIN LTRLPSTFSG LCSLGKFEAT HCNLQGMIPD DFEKLCSLKI LSLSFNNFHG LPSSLRGLSL LEQLLINGCQ QLVAIPELPI SLKKLDAGEC TSLQTMPKLS HLCKLETLSV HRCVQLVAIP ELPTSLKYLD AAVCTRLQTM PQLSHLSKLE NLYIYGCEQL ASIPQLPTNL KHLFADKTKS LQELLFRSRP LWLQISYMNC EQLVCIPELP SSLVGAVGYS ESAHHFEIKV RVLPTGYSCK SFLEGRICLA YKPGVTKDSI QEKPPEFFNW IVNASLQPRY VTRHPGEKSG CRL // ID W4YRH6_STRPU Unreviewed; 896 AA. AC W4YRH6; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SPU_018409-tr}; OS Strongylocentrotus purpuratus (Purple sea urchin). OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; OC Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; OC Strongylocentrotus. OX NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_018409-tr, ECO:0000313|Proteomes:UP000007110}; RN [1] {ECO:0000313|EnsemblMetazoa:SPU_018409-tr} RP NUCLEOTIDE SEQUENCE. RA Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y., RA Muzny D.M., Worley K.C., Gibbs R.A.; RT "Genome sequencing for Strongylocentrotus purpuratus."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:SPU_018409-tr} RP IDENTIFICATION. RG EnsemblMetazoa; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAGJ04080765; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EnsemblMetazoa; SPU_018409-tr; SPU_018409-tr; SPU_018409. DR OrthoDB; EOG091G0NGT; -. DR Proteomes; UP000007110; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR031283; AMIGO. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24368; PTHR24368; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000007110}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000007110}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 896 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004853108. FT TRANSMEM 688 709 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 736 886 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 896 AA; 103613 MW; 67FB4001070F8508 CRC64; MAGTRLIPLS VVLHTVVLAL IEVSLQYERS QGNHIRYLDL KTTNCSLGPS QESISCTRLD LKDVPHDLFP GVEELNLSFN QIRYLKNSSF RPYSRLRILS LFYNYIEEIG IGSFHSMPDL ENLDLGFNDN LKSITSEMFR ISTKLAYLSF DGDLALEFIP SDILRWLPNL RILNLNDTAI SQINITTCSS PLRKLNIYLE NNSITNITNS TFVIDCELNS LYLEPLGRPQ ILTIDPYTLA TLRSKTFSLA WNTMSSELWK LFFIGIGNSK IEELILHNAY IEDIDPHYYA PMQNSKLQVL DLSDNNFTSI TKQGFLDLPH LHTLVLDRCQ IGVIYPKDFA RMKGLRVLHL NSNHISDIGF FLSNPKWEIN LQELYLASNS LGVIHERSFA GLNNLKILVL AGNTDLKLLT ISSLTNFNLS SLQYFNLACV SKMGVYTPNL QTFISKDCYD KSSRYTNTNL GFMLNHSKFI KNISLENNYL ESLWYYIDLF EVSKVSLFEG RRSLTTLDLK KNPLATLQSG LFLDLLFLQE LDLSYCELFQ IESKTFEGLQ RLKTLYLQGN KLHGLPRKVF QNSGELATIL LEGNKLRYLE HDLFVNSSKL QNLTLAGNRL SGFNRSTFEP IFTNLISIDI SNNEFVCTCN LKWLPLWLSG SITLLDENDT RCSPASLEEL RESPLLSFKP AELCGTNVFL YTLLPLGIIC ITVLLIFAYR HRWFLKCKIF LLKLAVIGYR EIPDARDFDD YEFHVNIMFA EEDEEWVRDR FRPVLEELLP EYERNLYGDD DLPLGMHYYD AVHYVVEMSY KTIVLVSRAA IKDNWFIIKF RTAADQVNDT QIENMVVIFL EDIPDDELPF LVRLYLSDRK PYLSWEEEEW FQEYFWQKLT KMLTINLRCN NVTPPE // ID W4YRH7_STRPU Unreviewed; 913 AA. AC W4YRH7; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 28-FEB-2018, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SPU_018410-tr}; OS Strongylocentrotus purpuratus (Purple sea urchin). OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; OC Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; OC Strongylocentrotus. OX NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_018410-tr, ECO:0000313|Proteomes:UP000007110}; RN [1] {ECO:0000313|EnsemblMetazoa:SPU_018410-tr} RP NUCLEOTIDE SEQUENCE. RA Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y., RA Muzny D.M., Worley K.C., Gibbs R.A.; RT "Genome sequencing for Strongylocentrotus purpuratus."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:SPU_018410-tr} RP IDENTIFICATION. RG EnsemblMetazoa; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAGJ04080765; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7668.SPU_018410tr; -. DR EnsemblMetazoa; SPU_018410-tr; SPU_018410-tr; SPU_018410. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR OrthoDB; EOG091G00DZ; -. DR Proteomes; UP000007110; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR031283; AMIGO. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24368; PTHR24368; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 10. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 13. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007110}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007110}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 39 56 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 705 726 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 753 903 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 913 AA; 105973 MW; EB4D4ADD202B9A7F CRC64; MSLSVQNDSN LNLSDGYCSV CFNIFLFQFL SNNMAHKRFI QLSAVLTILV VTVISFQEVK LNHQGLTSRT KCYLGPFQRN ISCTNMGLKE VPQDLFPGVE ELDLSSNAIP YLYNVSFMPY KRIKKLSLYY NDIKGIAPTA FQSMPELQYL DLGRNYYLFS CFKSEIFRPS KKLSHLSFSG SPMREIPNDT LRWLPSLQML DLSETDLRYI NVTCNSAVHN LTVDLQGNIF GAIQSTAFKI DCQLDFLNLS RWLDSFYMYL NPDTIAAIRS RSLSFDRNHL LPEIWKLFFT GVGNSEIEKL LLRTTNVGNV HPEFFALLGS KRLRVLDLSN NNLSNFFKQG FVTLPFISTL ILNRCAIDYI DPTYFSRMKG LRVLQLNFNK IRFIGQEYSN SSWDIDLQEL YLVSNPLVRI YKTSFKGLTN LTKLVLRGNE DLYDIEFRAN NLRYLDLSGC IQLISVMTHL PNLETLVYSN CKTDEFMSYM GQILSQTEST KHIFLGNSSI YSLWTPFTGN NISLFQGMRN LISLDVKMNR IKLLEAGLFV DLVYLIQLDL SNCQINVIEE NAFEGLQRLH TLNVQGNHFQ FLPPEVLKNV GQLHNIHLEG NQIRYLDRDL FVNKSKLKYL TIADNRLTSL NHSTFQPILN TLSFIDISSN ELGCTCELKW LPIWLAGPIT VLNENDTRCS SSSIDELREK PLMSFKPAEL CGPNIALYCS LSIVISWIIM VLVFAYRHRW FLKCKLFLLK LAVIGYREIR DARDYDDYEF HVNIMFAEED EWWVRDHLRP TLEELLPEYE RNLLGDDHLP LGMHYYDAVH YVVEMSYKTI VLVSRAAIQD NWFIIKFRTA ADQVNDTQIE NMVVIFLEDI PDNELPFVVR LYLSDRNPYL SWEEEEGFQE YFWQKLTKML TINLRCNNVI PPE // ID W4ZG59_STRPU Unreviewed; 854 AA. AC W4ZG59; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 28-FEB-2018, entry version 33. DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SPU_027164-tr}; OS Strongylocentrotus purpuratus (Purple sea urchin). OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; OC Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; OC Strongylocentrotus. OX NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_027164-tr, ECO:0000313|Proteomes:UP000007110}; RN [1] {ECO:0000313|EnsemblMetazoa:SPU_027164-tr} RP NUCLEOTIDE SEQUENCE. RA Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y., RA Muzny D.M., Worley K.C., Gibbs R.A.; RT "Genome sequencing for Strongylocentrotus purpuratus."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:SPU_027164-tr} RP IDENTIFICATION. RG EnsemblMetazoa; RL Submitted (JUN-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAGJ04109369; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 7668.SPU_027164tr; -. DR EnsemblMetazoa; SPU_027164-tr; SPU_027164-tr; SPU_027164. DR eggNOG; KOG4641; Eukaryota. DR eggNOG; COG4886; LUCA. DR OMA; DIKISHM; -. DR OrthoDB; EOG091G00DZ; -. DR Proteomes; UP000007110; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR031283; AMIGO. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24368; PTHR24368; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 11. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000007110}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00889600}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000007110}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 854 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004853738. FT TRANSMEM 647 668 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 698 845 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 854 AA; 96756 MW; C6C2E076ED463D86 CRC64; MAAMICVHLV LVASGIVFLL LPQSEGTAKD VASNKNLPKC HLNNSSHGII ANCRNLGLRA VPQDLPIEVN TLDLSSNNIT TLHDESFKHL PNLVTLAAYD NFKGCSRWSH LTEVTLRMNE VQEIHQSDFL PLQNTTVGTF SLFGNKIHNL STKAFSHLTS IDSFILQGNS LKSFDIQPFL GMTYIKKLSV WGCGIHQLLP PDNASDYHTP YPSILTLDMR RNSVEYVPPG SFWGFIRLKK LLLSSNKISS LSNKSFSQLT SLIELDISYN KLVSLPPETF ACLPNLTTLN LSKNLLQNLS PPSYDGMPLI QSISVSGNKI THFNMGKHLW ALGTLKVLDM SNNDIPSIPN GRFTGLTNLE VLNLSQNQVT TCSKYAFTDL VLLKKLQLSN EIGLLLKDTF KQLRTLLYLD LSYTSIKVSR NAIEQFNNMA CLKDLHLERT ELRDTDLYNG INNRSLFSGL FSLKKLRLND NYLVSLDKRV FHNLSNVYYL DMSKSRIQVL RLGVFSPLSS LKFLYLRENK LVEMAGDIFH GLYQLRVVNI PDNILRGLKP TTFAQAPRLT DLSLSGNQIS TIGRGTVLPA NTSLRLDISR NPFTCTCSLT WFRQWLQSAD IDLKHAEKTL CSKTSLQGVV NQPIMAFHPE DHCGADIVLI TVLTLTGVVL VMISMLAYNK RWWLNHKLFL LKLAAIGYEE MAEDFNADNY RHHLNLMFEE AEQEWVDRVM RPALEERMPH LQNIIFGDEG LHLGMYYIPA LYDAIDNSFK TVLLLSNQSV NDAWTMTKLR MALEHLNDSG LDKVILIFVE DIEDENLPYL VRLFLSRNKP YMLWTDDEDG QELFWAQFEK SMRANKAINN AIPL // ID W5KW72_ASTMX Unreviewed; 624 AA. AC W5KW72; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 22. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000011834}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011834, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000011834, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000011834}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000011834} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; APWO01084006; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01084007; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; APWO01084008; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSAMXT00000011834; ENSAMXP00000011834; ENSAMXG00000011502. DR GeneTree; ENSGT00760000119071; -. DR OMA; PERCDDW; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}. FT DOMAIN 15 123 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 233 338 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 391 535 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 624 AA; 70865 MW; 895D81C995608074 CRC64; MVVKLTCASL TEAPPTLESG SQCLDIGLSR SMRVIAGESG RIPCPPFSFP TLYSYNQSSG QTLLWYRHTD THELEEPIHL RTHRFLKYRD SLWIQPTTLQ DSGLYICMLR NNSSCVKMGV QLQVFARVGM CDSAVHQNII VPLDSQCTLR CPDQQHLPTN STHNVTWYYK CMKEFTGVHR ELKGDELVIY IMYDHYAGPY TCVVSYQSGG HTLQFTRTIN IRAVPPRRGT KHPRILNPAS GQIYKVTLGE DAELTCRVYL PYLDDEEGLV WWTIDNKTGK CVCVCVCLHV FRVEDDDDDK TVLTMLRVKE FSAADLLREF RCSAQNSRGL NFSIATLEKE VYIPTVELAC GLGVTLALAV LLIVLYRVFK LEVHLLYRTW FGTDERNIDD KEYDVYISYA RNGEEEEFVM TTLRRVLEVD FGYTVCIFDR DSLPGGNLLE CVFRCMQASR RLLVVLSSEC VCEKSVSLLE CRLCVYLHHT LHTPLITIRR CTLGATCGEL TELRRSSTCI RWHGARSERA GSRFWKLLRL ALPVRPLALG RRLIDSTSSH SDLAAVALRH THTLSHMRQG GVVRGAPKVT GQRGQRQRGR GCDQKGQGCV VCVNFLESRR IWGGATVPQW NTRL // ID W5LUE9_ASTMX Unreviewed; 1058 AA. AC W5LUE9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 36. DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSAMXP00000026765}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026765, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000026765, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000026765}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000026765} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; APWO01000087; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007227775.1; XM_007227713.1. DR Ensembl; ENSAMXT00000026786; ENSAMXP00000026765; ENSAMXG00000026060. DR GeneID; 103027598; -. DR KEGG; amex:103027598; -. DR GeneTree; ENSGT00760000119006; -. DR KO; K05404; -. DR OMA; SSVLEWP; -. DR OrthoDB; EOG091G023M; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR026880; TLR7. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF1; PTHR44312:SF1; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 11. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 1058 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004867130. FT DOMAIN 897 1045 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1058 AA; 122291 MW; DEFA109F1D48D3DD CRC64; MAEMTLLPIT VLLLFFQSVW LQSSWYPKSL PCDVIRASNG TEVAVDCTSR SLTRIPAGIP SNATNLTLTI NHIPHIQNTS FQGLDNVTEI DMRCNCVPIK IGPKDHMCTQ SVTIDNGSFW QLKNLKSLYL DGNQLSSIPK GLPPNIVLLS LEVNRISTIL KENLTEVPNI QFLYLGQNCY FRNPCNMSYY IEKDAFFHLE RMTLLSLKSN NLSYIPHRLP SSLKELYLYN NNIQQVTEQD FQNLTDLEIL DLSGNCPRCY NAPFPCVPCP NNAPFQIAEN AFQNLTKLQI LRLHSNSLTV VNKEWFQGCK QLKVLDLSSN FLGKAITYTS FPHYLPFLEE LDLSFNYELQ RYPSSLNLSR AFSHLKSLKI LRIRGFVFQE LKRQDILPLI SLDKLEMIDL GTNFIKITDL SILTELKSFH IINLSDNKIS SPSEGESPGA LTMTARGAPD QYFTSPMSRG AQYQSGDVRE IHYFRYDEYA RSCKYRDKEV GTLSPFNTQC SSFGKTLDIS RNNIFFLHSR FLNLQELRCL NLSGNAMSQA LNGSEFAYLK NLQYLDFSRN RLDLMFSTAF QELSNLVVLD ISYNNHYFEA EGLTHMLNFT KNLNKLTKLI MNHNQISTST NTEMESFSLE HLEFKGNRLD MLWRDGDLRY VNYFKKLMSL KTLDISRNNL NFIPKQVFQG LPQTLIELNI TNNKLKSFNW EFLKYLKNLQ VLDLSSNQLK TVPAKLSNCS KSIVMLVLRK NEIASLTPNF LQDATSLRNL DLSYNQIKYI EESSFPENVI DNLQVLYLNN NRFICSCNAT WFVRWINRTT VNIPRLATDV TCAAPGTQRG QSVIFLNLQA CQHNYVSIML SILTTSLILS ILTLAISSHL FLWDVWYIYH FCLAKVKGYR RLLPDSTAYD AFVVYDKTDK AVSDWVMQEL RLQLEDRGER RLQLCLEDRD WVPGCPLIEN LSESIQLSKR TIFILTGRFI KSGHFKTAFY LAHQRLLDEK NDVIILIFLE KFSSSHSKYL RLRKRLYKRS VLEWPRNPRA QPYFWFCLKS VMAAESQQHY NKLFQETL // ID W5LUX5_ASTMX Unreviewed; 1066 AA. AC W5LUX5; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Toll-like receptor 9 {ECO:0000313|Ensembl:ENSAMXP00000027050}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; OC Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000027050, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Ensembl:ENSAMXP00000027050, ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000027050}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAMXP00000027050} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; APWO01034205; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_007237059.1; XM_007236997.1. DR RefSeq; XP_007237060.1; XM_007236998.1. DR Ensembl; ENSAMXT00000027071; ENSAMXP00000027050; ENSAMXG00000026345. DR GeneID; 103036522; -. DR KEGG; amex:103036522; -. DR CTD; 54106; -. DR GeneTree; ENSGT00760000119006; -. DR KO; K10161; -. DR OMA; KHLYGWD; -. DR OrthoDB; EOG091G0BWK; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 14. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018467}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Membrane {ECO:0000256|SAAS:SAAS00598878}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 1066 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004865141. FT DOMAIN 897 1047 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1066 AA; 121956 MW; B4E044862FD96449 CRC64; MFGPRLFLFV VLNHLCVVKA INLKFYPCDN TTASNGDINV DCGHRGLTSV PKFKSPIVVS LNLNENLIQR VKREDFSDLP NLQNLSLMWN CLPGRLKALR LPSCKVRIDQ DAFVNLKNLS SLYLVGNSLD TIPLLPQRLQ VLGLEFNNIF HIEKPLGTPF LKQLLLSKNC YYANPCNQSF SIETRVLQDL PELRNLTLGF NNITTVPVQL PPSLESLDLR ENKITEITKE SFANLTKLRY LNLEWNCQRC DHAAEPCFPC PNNASLGLDP GAFHDQRSSL SFLSLRGNSL HYLPKNIFAQ LSRLKTLDLS DNFLAYSIHN GTFFEELQKV VSLNLLYNYQ PMKTFPELIL SPYMSRMRAL KKLSLSGFFF HQLSNYSLEP LFDLPKLEYL DLRMNFISSC NVTAFSQLRA LRMVVLSQNM LAFNPCYKAI SMDIQLTSMT LSDRKREDPL ENQEDPYFRS ELERNSGQCA EEDCPINDSM WYLQRCHCYG KLSFNLSQNN IPWLNASTFK GMENAVCMDL SYNYMSQTLS GQQFSPLTKL IFLNMAHNRI DLYFDDAFRE LRSTLKALDL SNNEFHFLMR GIGHRFEFIK NMTSLEALSL ANNNIGLRIS NILRSTSLKY LFFSGNRLDI MWDTRGDQYI RFFQGLIKLR YLDISDNQLR SFSPEAMANL PKSVQVLRVD SNILNYFPWG NLSTLAQLCF LNLSGNHLSN LPDIAVPFGP KLSSLDLSHN RLTAIPESFF SQATALKDLR LDHNQLKIIE KQVLPSSFKS AICSTAFKTK NCKLTLHANP FICSCVTSWF AEFLRGSPLF IPHLTTDVRC GFPESQTGVN VLAIDPRSCQ EIFGSVAFLF TSLLALAATT IPILKHLYGW DLWYCFQILW AGHKGYTSLQ GNSMVNNDHD AFVVFDTQNK AVRDWIYNEM VANLERRGRW QFKLCLEERD WVPGVSCIEN LHNAVYNSRK TVFVLTNNGS FSSVSGIIRQ AFLLVQQRLL DEKVDVAVLV LLDSVFPKVK YLQMRKRLCK KSVLSWPKNP QAQPLFWNDL CVAIASDNVK SYDKKVTESF LSHELL // ID W5MQI3_LEPOC Unreviewed; 592 AA. AC W5MQI3; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 21. DE SubName: Full=Interleukin 18 receptor 1 {ECO:0000313|Ensembl:ENSLOCP00000010642}; GN Name=IL18R1 {ECO:0000313|Ensembl:ENSLOCP00000010642}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000010642, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000010642, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000010642} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR Ensembl; ENSLOCT00000010657; ENSLOCP00000010642; ENSLOCG00000008743. DR GeneTree; ENSGT00760000119071; -. DR OMA; TWHKENG; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR004074; IL-1_rcpt_I/II-typ. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR PRINTS; PR01536; INTRLKN1R12F. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 3. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 15 31 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 384 408 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 73 148 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 266 368 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 430 579 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 592 AA; 67587 MW; 657194F952E0D593 CRC64; MRCALGVPAS SQENFIALCF TMGMLIMRGM TRRVEKKRDK LTRGHFSQNM KIIFQILIVL FAAFKERVHC CSPSSKSEVF AHEGELAVLK CTSSVKCDDS SLRSDWIVSS SGGFMKLTSG VRDSLIIKRK WLIILGVTLN DTGLYQCTQR CSNGTDIISS NKYNLTVYGG KCFTEEDLYR IKKNTGNSFT LSCEDKDIPL SISHITWLKD CNQVYNSEQV INIASLMKSH AGKYTIIYSY TYGNRHYNLS ETTELVVKDS SDLLDPKIIH PAENKTIEVE IGKEIVINCT AVIYRKPKLK TLYWLKNKEF VEVCDGNKSV CCKESSEHKP HNKYHMVSSL VFKSVTKECL NILYTCKLDS AQKNRKVFIT LQLKETNQQG VSTVYLWLGI LGCFALSAST FTAIYIQFKI EIALLYRNIT GKDDTVGDGK TYDAYVTYYK IKSSKSFFEK ERKSLLEVLE EHYGYQLCIY ERDVLPGGAF ADTILEYIDK SRRLIMIPSA DDPAHESQYE LVTGLYNALV DKKIQIIIIQ CEPKADLDSF PEPLRLLLKS NGAVRWKDRK SKELDSVFWR KLRYMMPAKK HAVPLPEQIK ML // ID W5MUZ7_LEPOC Unreviewed; 1039 AA. AC W5MUZ7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 37. DE SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSLOCP00000012206}; GN Name=TLR8 (1 of many) {ECO:0000313|Ensembl:ENSLOCP00000012206}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012206, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000012206, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012206} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AHAT01012853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_015216941.1; XM_015361455.1. DR RefSeq; XP_015216942.1; XM_015361456.1. DR Ensembl; ENSLOCT00000012227; ENSLOCP00000012206; ENSLOCG00000009982. DR GeneID; 102685072; -. DR GeneTree; ENSGT00760000119006; -. DR OMA; LNISCIN; -. DR OrthoDB; EOG091G023M; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0051607; P:defense response to virus; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR026906; LRR_5. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13306; LRR_5; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 15. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 1039 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004866817. FT TRANSMEM 827 852 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 876 1023 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1039 AA; 119844 MW; 4597AF567E79C03D CRC64; MLTTSPLQNR MLCLFVITTF VPSILTNCWV SKHLPCDVMI RNDTSILFDC SARRLTVVPT DIKCNVTSLR LSQNQIQHIS NESFWNLENL IILNLKWNRD TEGLKIAKGS FTALKKLKIL LLDGNLLSTI PEDLPHELNI LSLSSNNIAS IGSENFKGIP NIKEIRLNKN CYHGNGCNNS LIIHNDTFSN VLELEKLSLN LNRLTRVPQN LPKYLKSLSL TLNKIERVNH FDLENLTELR TLDLSGNCPR CQNAPFPCET CKTPKGSIEV DPHAFQSLVN LEELHLSGNS LVKVHASWFQ NCTKLKYLFL SFNFLISEIA TGEFLNVLPH VEVIDLSFNY APKSYPRKIK LSSNFSKLEA LRALHIEGYV FRILDGNDLN PLFSLKNLSL LNVGTNFLQY IHLTLFQNFF NLSLIYLSEN RLASLSQRND SIYANGNEAD CVLNKPLMKY HGNHEEKGTY IVHKDKDYRL SHPLVKQQCL RYGPVLDLSK NNIFYISPEL FKGLENTTCL NLSKNSIADS FNGTEFIHLP KLKYLDLSYN KIDLAYDYAF SELTHLEVLD LSNNPHYFVV AGVTHNLNFV KHLQVLKVLN LSQNEIFTLT EKEMSSSSLK ELQFQGNRLD ILWKNDERYI RLFTNLLNLT HLDMSHNKLQ NIPSAAYENF PKTLTHLFLN NNKLNLFKWE KLIYFECLEV LDLSNNKIES IAEHIANYTK MLRKLYLGNN KISRLSDGFL RGARSLSRLY LDNNNLSLIN TSTFLSGPEN YLKTLSLKGN PFQCTCEIFD FLLWVEGTDI VIPRLATDVT CATPERLKRN AVIGFDRQQC IIDGTSAILF LASSSIIVIT VAVAITQHLF YWDVWYIFHY LKAKMKGYHY LKSTESIYDA FITYDTKDPV VSDWVLNHLR VQLEENGEKL FPICLEERDW HPGAPVIDNL SQSIKQSRKT VFVLTEGYVK SGTFKIAFYL AHQRLLDDNT DVIVLVLLEP VLLHSQFFRL RKRLCRKTIL EWPKNPRAEK WFWHCLRNII RVEHQAVYNK LYSCYFINK // ID W5NAU9_LEPOC Unreviewed; 1039 AA. AC W5NAU9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 31. DE SubName: Full=Toll like receptor 9 {ECO:0000313|Ensembl:ENSLOCP00000017758}; GN Name=TLR9 {ECO:0000313|Ensembl:ENSLOCP00000017758}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017758, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000017758, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017758} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AHAT01014872; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSLOCT00000017790; ENSLOCP00000017758; ENSLOCG00000014430. DR GeneTree; ENSGT00760000119006; -. DR OMA; CRRCDHA; -. DR OrthoDB; EOG091G0BWK; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 13. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 20. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 1039 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004869492. FT DOMAIN 875 1022 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1039 AA; 115453 MW; E76F84898CF7C9C3 CRC64; SSPQASPRGA AALPGFLAVL VSLLPPGAAT YPPFLPCGSP SPQTVDCAAH GLTRVPLFRA PTGAVTALLL SGNHISRIPA DAFALFRRLE TLELQWNGLL RPGVPKAGGP MVLAPRAFEP LAQLRSLDLR GNGLRAVPLL PPSLRTLDLS YNRLLLLEPP ARPPALAALQ TLRLDGNCYY NNPCGHSQGA PRGFLAGMGR LRELSLGHNN LTAVPGGLPA GLRRLALHYN QISAVAPGDF GQLARLSSLD LKGNCRRCEH APSPCIKCAR SALHLPAGCF ASLGSLKSLN LSDNSLASLN DSVFAPLRGL EELLLSDNLL SRTSPNGNDL VLGSPAFRGF PRLRSLDLSY NYRRFTVFRR LALTEDFAGL ARLQSLQITG CFFQSVDNAS VAPLAGLPEL RLLNLRLNFI KNIELHIFDS LAGLSYLRLS DNEISCTRCR GAPGKRPGLP DHRLTPGSSL QARGLIAPEP QVGLPLPESC TGRETLNLMR NNLVYVQKEL FEGFERIECL ILSHNSISQS FNGNQFILLK RLKLLDLSYN RIDLYYKAAF SELPSLEVLD LSNNNYHFQL SGMGHRLDFI AGLPSLRLLD LGFDSISDRI STALASSSLN KLVFRHNRLQ DMWNKKIYFQ FFRNLTNLTS LDLSNNLLTR IPPEGIYHLP PTLRDLNLKF NKLTSFPWEA LSAFPCLEIL DLSYNWLSTL SRSLHPGSYI PPDSGLRSLN LSSNRIHAID RDFFRNATAL ASLLLSDNQL EQLDFDNFLL QRLRVLDIRW NRLVCTCDSS FYELFGNFNF SVPALTSQVT CGSPDKLRGR SVFSRDAPLC PGSRNMAAFL LSLALALPLT ALPVLRQVLG WDAWYAFYVW VARAWGLFYK GGEGSAYDAF VAFDKEQESV ADWVYNELRV QLEDSGAQRF RLCLEERDWL PGRSSIENLH EAVQGSRKTV FVLPRAGPAG GLLREAFFLA QQRLLEERAD VAVFVLLEKG RRGSRYLQLR RLLCRETVLL WPQNPQAQGY FWHRLRCVLG RDIQASYDRK HCRGVPTPL // ID W5NP58_LEPOC Unreviewed; 965 AA. AC W5NP58; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 32. DE SubName: Full=Toll-like receptor 22 {ECO:0000313|Ensembl:ENSLOCP00000022417}; OS Lepisosteus oculatus (Spotted gar). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; OC Lepisosteus. OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000022417, ECO:0000313|Proteomes:UP000018468}; RN [1] {ECO:0000313|Ensembl:ENSLOCP00000022417, ECO:0000313|Proteomes:UP000018468} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.; RT "The Draft Genome of Lepisosteus oculatus."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSLOCP00000022417} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AHAT01005505; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSLOCT00000022458; ENSLOCP00000022417; ENSLOCG00000018316. DR GeneTree; ENSGT00760000119006; -. DR OMA; HISKIDS; -. DR OrthoDB; EOG091G024T; -. DR Proteomes; UP000018468; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0052033; P:pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; IEA:Ensembl. DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 4. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 3. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 16. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 18. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000018468}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000018468}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 965 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004867907. FT TRANSMEM 774 791 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 804 948 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 965 AA; 110458 MW; BB98B0A1B7B164DF CRC64; KILIPLGKSM HFIYLVSCCL LPTWVRFAPT AGYSLGSCVA HGSLNYTNRL KVLCYSEQLR LVPSNIPPNV TVLDISDNLI SRIQLENFRN LSNLRVLNVS RNLISRVAEG AFKHLVNLQE LNMARNKLSV LSENIFEGLG NLTVLQLGDN NIKSVESTAF RFLLSIRFVN LTTNELQHLN KVRPILKFPH LQQLHVGNNS LFTFQTEDLS DFPLALKVLD LSWNPLTKLN VTTDILPKLE SLDLSYSGTN GSEEWYIRDG FLLRDVKKLS LNGTNISEEV LFSVLQCLNS SLEVLTMSNL KHLKVKAFLN VTCQMLPLLR VFNLQGNSLG SLGDGLKPCS LLRDLDLSRN KLVQVADFVF KNMSQLHALN LSYNQLNAVP VAVRIITSLE TLDLSYNSIS ELKSSDFAKM TMLKELYLVN NLIRDINGSA FQDLINLRSL RLGKNHIWMI TYPMFLSLRK LVVLDLKSNQ LSSLKNGTFQ NLNSLKSLNL VDNQISEIEE GAFQGLLNLT TLLLGSNKIT GDILRTGTVF SGMPALRELQ LFDNFISYES TAKLKSPPFS LLKSLKTLSL NSQGHEGLLN LPSNFLEGLD SLIELHAGRL NINFLHPQTF SYTPKLSFLD ISRNAIGNLT PQLFQPIPNL TEFILTQGRL QTLDFLIHAN LTQVKILRAK GNELTVITES LIRSLPSVKY VDLRENSFSC DCDNSWFLKW ALHDTYAQVI YMNTYFCKYP PNLRGMKLID LKMDSCSVDL EFICFISSTT LVALTLLASF FYRFLRWQVV YAYYLFLAFL YDNRKKRRRP VLQYQYDAFV SYNTHDELWV LRELLPNLEQ VQGWRLCLHH RDFEAGKPII DNIVDSIYNS RKTICLISRH YLESEWCSRE IQVASFRLFD EQKDVLILVF LEDIPACQLS PYHRMRKLVK KRTYLKWPGH REETRMFWHK LNIALQTRGE ADEENPLLSG LDTQD // ID W5P4M0_SHEEP Unreviewed; 871 AA. AC W5P4M0; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Toll-like receptor 5 precursor {ECO:0000313|Ensembl:ENSOARP00000005373}; GN Name=TLR5 {ECO:0000313|Ensembl:ENSOARP00000005373}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005373, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000005373, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005373}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000005373} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AMGL01020947; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000005460; ENSOARP00000005373; ENSOARG00000005017. DR GeneTree; ENSGT00760000119006; -. DR OMA; KYDAYLC; -. DR OrthoDB; EOG091G030N; -. DR Proteomes; UP000002356; Chromosome 12. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:Ensembl. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl. DR GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0034146; P:toll-like receptor 5 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 3. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027176; TLR5. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44698:SF2; PTHR44698:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13516; LRR_6; 1. DR Pfam; PF13855; LRR_8; 4. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 12. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 10. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 653 673 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 704 840 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 871 AA; 99430 MW; AE5988349899DE05 CRC64; MSVSSLSLLF HRIMGDCLDL LLGVVLLTRP ALGISSCFFD GWRAIYLSCN LTQVPQVPNT TKSLLLSFNY IRTVRTTSFP FLEQLQLLEL GTQFTSLTIY REAFQNLPNL RILDLGGSQI DFLHPDAFQG LPHLTELRLF FCGLSDAVLK DGYFRNLASL TRLDLSKNQI QSLHLHPSFR ELNSLKSIDF SLNQIPIVCE QEFKPLQGKT LSFLSLADNH LYSRVSVDWK RCLNPFRNMV LETLDVSGNG WGVDIMRNFS NAINGSQIFS LVLTHHIMGS SFGFSNLKDP DQHTFAGLAR SSMIQLDISH GYIFSLNSRV FETLQELKVL NLAYNKINSI SRNAFYGLDN LQVLNISYNL LGELYNHDFN GLPKVAYIDL QKNHIGIIQD KTFKFLGKLN TLDLRDNALK TIHFLPSIPN IFLGGNKLVT LPNIPLTANL IQLSENRLEN LNDLYFLLQV PHLQILILNQ NRFSFCPQNH APSENPSLEK LFLGENMLQL AWETKSCWDI FKGLSHLQLL YLNQNYLNFL PPGVFHHLTA LRGLSLRDNR LTVLSPGDLP ANLEILDISG NQLLSPDPDL FASLSAMDIT HNKFICDCEL SAFIHWVNQT NITISGSPAD MYCMYPNSLA GVSIYSLSTE GCEEEEFLES LKFSLFILFT VTLTLFLVII LMVTKFRGFC FICYKKAQSL LFKDPIKGRE SDTYKYDAYL CFSSKDFEWV QNALLKHLDV QYSNQNRFNL CFEERDFMPG ENHIANIQDA VWSSRKTVCL VSRHFLRDGW CLEAFSYAQS RCLADLNGAL IMVVVGSLSQ FHLMKHQSIR GFVQKRQYLR WPEDLQDVDW FLNKLSQCIL KKEKERKKDS AIQLQSVTTV S // ID W5PU79_SHEEP Unreviewed; 585 AA. AC W5PU79; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSOARP00000014010}; GN Name=IL18RAP {ECO:0000313|Ensembl:ENSOARP00000014010}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014010, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000014010, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014010}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000014010} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AMGL01078650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000014217; ENSOARP00000014010; ENSOARG00000013079. DR GeneTree; ENSGT00760000119071; -. DR OMA; YVCDYTQ; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000002356; Chromosome 3. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008283; P:cell proliferation; IEA:Ensembl. DR GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl. DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl. DR GO; GO:0042119; P:neutrophil activation; IEA:Ensembl. DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl. DR GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 2. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Repeat {ECO:0000256|SAAS:SAAS00938886}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 585 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004871204. FT TRANSMEM 361 387 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 51 127 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 151 241 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 253 355 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 408 564 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 585 AA; 66550 MW; A713682861FE20E3 CRC64; MLCLGWIFLW LVAQGRIRGL NTPDCFTEKP LRTYSARCGE EFVLFCDLPE PQKSHFYHGS QLSPTQGSEY LPCRGSENLS DVQWYLQPQN GDPAVEITQN APQVIQEKST LHFLTTGINH AGLYICRPRM SFPRSPQENA CCVRMILEVK PQTNMSCESA VSHEQHLLLG SMSSIYCPGL SHQSDAQSPE VTWYQNGKLL SEKRSNPIEV DEVYDYHQGT YVCDYTQTDN SSSWTVRAVV QVKTIVKNTN LKPDILDPIK DTLEVELGKP LTLNCTARFG FEINFNPVIK WYIRDSDQEW EIETPKGRSV KSTLKDEVIE RVVLLEKVTE SDLHKKFICF AQNSIGNTTQ SIQLKKKTGA VFLYVLLGTV TGLAGMLTTG ALFYMYWIEI VLLYRTYQSK DETLGDQKEF DAFVSYAKWS PFESEASSSL SEETLALNLL PDVLENKYGY TLCLLERDVA PGGVYTEDIV SVIKKSRRGI FILSPNYVSG PSIFELQAAV NLALEDQTLK LILIKFSSFQ EPESLPHLVR RALRVLPTVT WKGLKSVPPN SRFWTQIRYH MPVKSSRGVT WNHLRIMPWI FSLQK // ID W5Q9A4_SHEEP Unreviewed; 437 AA. AC W5Q9A4; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 25. DE SubName: Full=Interleukin 1 receptor accessory protein like 1 {ECO:0000313|Ensembl:ENSOARP00000019296}; GN Name=IL1RAPL1 {ECO:0000313|Ensembl:ENSOARP00000019296}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019296, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000019296, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019296}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000019296} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AMGL01114424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AMGL01114425; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; W5Q9A4; -. DR Ensembl; ENSOART00000019564; ENSOARP00000019296; ENSOARG00000017975. DR GeneTree; ENSGT00760000119071; -. DR OMA; ITHEQVL; -. DR OrthoDB; EOG091G0GXW; -. DR Proteomes; UP000002356; Chromosome X. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR015621; IL-1_rcpt_fam. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR11890; PTHR11890; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF01582; TIR; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50104; TIR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 101 122 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 144 303 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 437 AA; 50249 MW; FEC52E742A9BC580 CRC64; GDSANLTCRA FFGYSGDVSP LIYWMKGEKF IEDLDENRVW ESDIRILKEH LGEQEVSISL IVDSVEEGDL GNYSCYVENG NGRRHASVLL HKRELMYTVE LAGGLGAILL LLVCLVTIYK CYKIEIMLFY RNHFGAEELD GDNKDYDAYL SYTKVDPDQW NQETGEEERF ALEILPDMLE KHYGYKLFIP DRDLIPTGTY IEDVARCVDQ SKRLIIVMTP NYVVRRGWSI FELETRLRNM LVTGEIKVIL IECSELRGIM NYQEVEALKH TIKLLTVIKW HGPKCNKLNS KFWKRLQYEM PFKRIEPITH EQALDVSEQG PFGELQTVSA ISMAAATSTA LATAHPDLRS TFHNTYHSQM RQKHYYRSYE YDVPPTGTLP LTSIGNQHTY CNIPMTLING QRPQTKSSRE QNPDEAHTNS AILPLLPRET SISSVIW // ID W5Q9N5_SHEEP Unreviewed; 1035 AA. AC W5Q9N5; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 28-MAR-2018, entry version 34. DE SubName: Full=Toll-like receptor 8 precursor {ECO:0000313|Ensembl:ENSOARP00000019427}; GN Name=TLR8 {ECO:0000313|Ensembl:ENSOARP00000019427}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019427, ECO:0000313|Proteomes:UP000002356}; RN [1] {ECO:0000313|Ensembl:ENSOARP00000019427, ECO:0000313|Proteomes:UP000002356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019427}; RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x; RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W., RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., RA Wang J., Wang W., Xun X.; RT "The sheep genome reference sequence: a work in progress."; RL Anim. Genet. 41:449-453(2010). RN [2] {ECO:0000313|Ensembl:ENSOARP00000019427} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2014) to UniProtKB. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|SAAS:SAAS00598595}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AMGL01113776; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSOART00000019697; ENSOARP00000019427; ENSOARG00000018099. DR GeneTree; ENSGT00760000119006; -. DR OMA; WPDNPKA; -. DR OrthoDB; EOG091G014D; -. DR Proteomes; UP000002356; Chromosome X. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0003677; F:DNA binding; IEA:Ensembl. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl. DR GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl. DR GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl. DR GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl. DR GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl. DR Gene3D; 3.40.50.10140; -; 1. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027175; TLR8. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF13855; LRR_8; 6. DR Pfam; PF01582; TIR; 1. DR SMART; SM00369; LRR_TYP; 16. DR SMART; SM00082; LRRCT; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 19. DR PROSITE; PS50104; TIR; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002356}; KW Immunity {ECO:0000256|SAAS:SAAS00472892}; KW Innate immunity {ECO:0000256|SAAS:SAAS00472892}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00473103}; KW Reference proteome {ECO:0000313|Proteomes:UP000002356}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00598878, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 1035 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004870028. FT TRANSMEM 821 842 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 872 1019 TIR. {ECO:0000259|PROSITE:PS50104}. SQ SEQUENCE 1035 AA; 118664 MW; 1C962B14BB6E307F CRC64; ENMTLRFLLL TSLFLLISDS CEFFTEASYP RSYPCDVKNK NGSFIAECNS RRLQEVPQTV DKAVTEVDLS DNFITRITNE SFQGLQNLTK INLNHNAKSQ SGNPAVKKAM TITYGAFLNL KHLRELLLED NQLQEIPAGL PESLKELSLI QNNIITLTKK NTSGLGNLER LYLGWNCYFA CNKKFSIENG AFQNLTKLKV LSLSFNPLHS VPPSLPSSLT ELYLSNTHIG NVSEEDFKEL SNLRVLDLSG NCPRCFNAPF PCVPCQGGAS IQIHPLAFQT LTQLRYLNLS STSLRKVPAS WFDNMHNLKV LDLEFNYLMD EIASGEFLTK LPSLEILDLS YNYELKKYPQ YINISKNFSK LISLQMLHLR GYVFQELRRK DFKPLQHLSN LTTINLGVNF IKQIDFSIFH WFPNLKIVYL SENRISPLVS DTEQHDANGT FFQSHILKRR SADIQFDPHS NFYHNTHPLI KTECSRLGNA LDLSLNSIFF IGVNQFKDFG NISCLNLSSN GNGQVLNGTE FSRLSGIKYL DLTNNRLDFD DDAAFSELPL LEVLDLSYNA HYFRIAGVTH RLGFIEHLTN LRVLNLSNND IFTLTETQLK SASLGELVFS GNRLDLLWNA QDVRYWQIFQ NLTNLTRLDL ARNNLQHISS QAFLNLPRTL TDLYINDNML NFFNWSLLEY FPHLRLLDLS GNQLFFLTNS LSTFASSLET LLLSRNRISH LPSDFLSGAS SLIHLDLSSN QLKMLNRSTF ETKTATKLTI LELGSNPFDC TCDFGDFREW MDRNLNVRVP RLTDVICASP GDQEGKSIVS LDLTTCVSDT IAAIFCFLTF SVTISVMLAA LAHHWFYWDA WFIYHVCLAK VKGYRSLSTS QTFYDAYVSY DTKDASVTDW VINELRFHLE ESEDKNVLLC LEERDWDPGL AIIDNLMQSI NQSKKTIFVL TKKYAKNWNF KTAFYLALQR LMEENMDVIV FILLEPVLQH SQYLRLRQRI CKSSILQWPD NPKAEGLFWQ SLKNVVLTAN DSRYNNLYVN SIKQY //