Analysis Type: PANTHER Overrepresentation Test (Released 20240807) Annotation Version and Release Date: GO Ontology database DOI: 10.XXXX/zenodo.XXXXXXXX Released 2025-10-05 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20580) upload_1 (181) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) fatty acid metabolic process (GO:0006631) 336 151 2.96 + 51.10 9.27E-254 1.35E-249 monocarboxylic acid metabolic process (GO:0032787) 530 152 4.66 + 32.61 3.14E-219 2.28E-215 carboxylic acid metabolic process (GO:0019752) 797 161 7.01 + 22.97 2.63E-209 1.27E-205 oxoacid metabolic process (GO:0043436) 818 161 7.19 + 22.38 2.74E-207 9.95E-204 organic acid metabolic process (GO:0006082) 827 161 7.27 + 22.14 1.93E-206 5.60E-203 lipid metabolic process (GO:0006629) 1221 165 10.74 + 15.37 9.34E-186 2.26E-182 small molecule metabolic process (GO:0044281) 1549 164 13.62 + 12.04 1.37E-165 2.84E-162 fatty acid biosynthetic process (GO:0006633) 130 75 1.14 + 65.60 1.74E-125 3.17E-122 monocarboxylic acid biosynthetic process (GO:0072330) 180 79 1.58 + 49.90 1.10E-119 1.78E-116 carboxylic acid biosynthetic process (GO:0046394) 283 87 2.49 + 34.95 3.09E-116 4.50E-113 organic acid biosynthetic process (GO:0016053) 287 87 2.52 + 34.47 1.30E-115 1.72E-112 long-chain fatty acid metabolic process (GO:0001676) 113 67 .99 + 67.42 1.37E-112 1.66E-109 small molecule biosynthetic process (GO:0044283) 474 89 4.17 + 21.35 9.84E-98 1.10E-94 unsaturated fatty acid metabolic process (GO:0033559) 105 58 .92 + 62.81 2.89E-94 3.00E-91 lipid biosynthetic process (GO:0008610) 593 90 5.22 + 17.26 4.37E-90 4.24E-87 icosanoid metabolic process (GO:0006690) 119 54 1.05 + 51.60 3.02E-81 2.74E-78 fatty acid catabolic process (GO:0009062) 92 49 .81 + 60.56 3.89E-78 3.32E-75 acyl-CoA metabolic process (GO:0006637) 98 48 .86 + 55.69 4.22E-74 3.41E-71 lipid oxidation (GO:0034440) 91 47 .80 + 58.73 5.29E-74 4.04E-71 fatty acid derivative metabolic process (GO:1901568) 85 46 .75 + 61.53 1.06E-73 7.69E-71 monocarboxylic acid catabolic process (GO:0072329) 116 49 1.02 + 48.03 1.51E-71 1.04E-68 lipid modification (GO:0030258) 154 52 1.35 + 38.39 8.29E-70 5.48E-67 fatty acid oxidation (GO:0019395) 84 43 .74 + 58.20 2.29E-67 1.44E-64 primary metabolic process (GO:0044238) 6771 169 59.55 + 2.84 1.04E-66 6.31E-64 metabolic process (GO:0008152) 7657 174 67.34 + 2.58 2.61E-65 1.52E-62 carboxylic acid catabolic process (GO:0046395) 232 55 2.04 + 26.96 3.03E-64 1.63E-61 organic acid catabolic process (GO:0016054) 232 55 2.04 + 26.96 3.03E-64 1.69E-61 lipid catabolic process (GO:0016042) 307 58 2.70 + 21.48 1.18E-61 6.12E-59 sulfur compound metabolic process (GO:0006790) 274 56 2.41 + 23.24 1.71E-61 8.55E-59 olefinic compound metabolic process (GO:0120254) 155 47 1.36 + 34.48 2.49E-60 1.21E-57 small molecule catabolic process (GO:0044282) 352 59 3.10 + 19.06 1.67E-59 7.84E-57 amide metabolic process (GO:0043603) 423 62 3.72 + 16.67 6.42E-59 2.92E-56 fatty acid beta-oxidation (GO:0006635) 60 35 .53 + 66.33 1.49E-57 6.55E-55 arachidonate metabolic process (GO:0019369) 62 35 .55 + 64.19 7.91E-57 3.38E-54 fatty-acyl-CoA metabolic process (GO:0035337) 45 31 .40 + 78.33 1.89E-54 7.84E-52 acyl-CoA biosynthetic process (GO:0071616) 47 31 .41 + 74.99 1.68E-53 6.77E-51 fatty acid derivative biosynthetic process (GO:1901570) 53 32 .47 + 68.65 2.50E-53 9.82E-51 fatty-acyl-CoA biosynthetic process (GO:0046949) 28 25 .25 + > 100 2.31E-49 8.83E-47 unsaturated fatty acid biosynthetic process (GO:0006636) 41 28 .36 + 77.65 4.95E-49 1.85E-46 very long-chain fatty acid metabolic process (GO:0000038) 35 26 .31 + 84.46 3.61E-47 1.31E-44 amide biosynthetic process (GO:0043604) 157 39 1.38 + 28.24 4.60E-46 1.63E-43 sulfur compound biosynthetic process (GO:0044272) 109 34 .96 + 35.47 5.56E-44 1.92E-41 long-chain fatty-acyl-CoA metabolic process (GO:0035336) 25 21 .22 + 95.51 2.50E-40 8.46E-38 long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) 19 19 .17 + > 100 3.30E-40 1.09E-37 purine-containing compound metabolic process (GO:0072521) 507 51 4.46 + 11.44 1.51E-39 4.88E-37 icosanoid biosynthetic process (GO:0046456) 52 25 .46 + 54.66 2.82E-38 8.92E-36 nucleoside phosphate metabolic process (GO:0006753) 579 51 5.09 + 10.02 1.16E-36 3.60E-34 nucleobase-containing small molecule metabolic process (GO:0055086) 605 51 5.32 + 9.58 1.02E-35 3.10E-33 organophosphate metabolic process (GO:0019637) 977 61 8.59 + 7.10 1.43E-35 4.24E-33 purine-containing compound biosynthetic process (GO:0072522) 242 34 2.13 + 15.97 3.70E-31 1.08E-28 long-chain fatty acid biosynthetic process (GO:0042759) 28 18 .25 + 73.09 5.07E-31 1.45E-28 biosynthetic process (GO:0009058) 4033 105 35.47 + 2.96 3.08E-30 8.62E-28 fatty acid elongation (GO:0030497) 14 14 .12 + > 100 9.94E-30 2.67E-27 fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) 14 14 .12 + > 100 9.94E-30 2.72E-27 catabolic process (GO:0009056) 2121 77 18.65 + 4.13 1.46E-29 3.85E-27 phosphate-containing compound metabolic process (GO:0006796) 1394 63 12.26 + 5.14 9.33E-29 2.42E-26 phosphorus metabolic process (GO:0006793) 1396 63 12.28 + 5.13 1.01E-28 2.58E-26 nucleoside phosphate biosynthetic process (GO:1901293) 297 34 2.61 + 13.02 4.24E-28 1.06E-25 very long-chain fatty acid biosynthetic process (GO:0042761) 13 13 .11 + > 100 1.22E-27 2.95E-25 linoleic acid metabolic process (GO:0043651) 20 15 .18 + 85.28 1.20E-27 2.97E-25 prostanoid metabolic process (GO:0006692) 40 18 .35 + 51.17 4.00E-27 9.54E-25 prostaglandin metabolic process (GO:0006693) 38 17 .33 + 50.87 1.28E-25 3.01E-23 leukotriene metabolic process (GO:0006691) 36 16 .32 + 50.53 4.09E-24 9.44E-22 organophosphate biosynthetic process (GO:0090407) 568 39 5.00 + 7.81 7.58E-24 1.72E-21 omega-hydroxylase P450 pathway (GO:0097267) 11 11 .10 + > 100 1.79E-23 4.01E-21 prostanoid biosynthetic process (GO:0046457) 21 13 .18 + 70.39 2.33E-22 5.13E-20 alpha-linolenic acid metabolic process (GO:0036109) 10 10 .09 + > 100 2.15E-21 4.67E-19 steroid metabolic process (GO:0008202) 267 27 2.35 + 11.50 5.54E-21 1.19E-18 lipoxygenase pathway (GO:0019372) 11 10 .10 + > 100 2.35E-20 4.95E-18 cellular process (GO:0009987) 15672 179 137.83 + 1.30 8.42E-19 1.75E-16 prostaglandin biosynthetic process (GO:0001516) 19 11 .17 + 65.83 1.27E-18 2.61E-16 sphingolipid metabolic process (GO:0006665) 162 20 1.42 + 14.04 1.68E-17 3.40E-15 fatty acid elongation, saturated fatty acid (GO:0019367) 8 8 .07 + > 100 3.06E-17 6.10E-15 sphingolipid biosynthetic process (GO:0030148) 107 17 .94 + 18.06 6.14E-17 1.21E-14 membrane lipid metabolic process (GO:0006643) 212 21 1.86 + 11.26 2.45E-16 4.75E-14 cyclooxygenase pathway (GO:0019371) 10 8 .09 + 90.96 1.36E-15 2.60E-13 short-chain fatty acid metabolic process (GO:0046459) 16 9 .14 + 63.96 2.80E-15 5.28E-13 fatty acid transport (GO:0015908) 92 15 .81 + 18.54 2.94E-15 5.49E-13 fatty acid elongation, monounsaturated fatty acid (GO:0034625) 7 7 .06 + > 100 3.62E-15 6.50E-13 fatty acid elongation, polyunsaturated fatty acid (GO:0034626) 7 7 .06 + > 100 3.62E-15 6.58E-13 fatty acid elongation, unsaturated fatty acid (GO:0019368) 7 7 .06 + > 100 3.62E-15 6.67E-13 epoxygenase P450 pathway (GO:0019373) 18 9 .16 + 56.85 1.17E-14 2.07E-12 membrane lipid biosynthetic process (GO:0046467) 148 17 1.30 + 13.06 1.64E-14 2.88E-12 fatty acid derivative catabolic process (GO:1901569) 19 9 .17 + 53.86 2.21E-14 3.82E-12 monocarboxylic acid transport (GO:0015718) 148 15 1.30 + 11.52 3.86E-12 6.60E-10 carnitine metabolic process (GO:0009437) 14 7 .12 + 56.85 1.18E-11 2.00E-09 leukotriene biosynthetic process (GO:0019370) 23 8 .20 + 39.55 1.34E-11 2.24E-09 medium-chain fatty acid metabolic process (GO:0051791) 15 7 .13 + 53.06 2.20E-11 3.63E-09 sulfur compound catabolic process (GO:0044273) 37 9 .33 + 27.66 2.59E-11 4.24E-09 long-chain fatty acid transport (GO:0015909) 54 10 .47 + 21.06 3.69E-11 5.96E-09 lipoxin A4 metabolic process (GO:2001302) 5 5 .04 + > 100 4.98E-11 7.95E-09 amino-acid betaine metabolic process (GO:0006577) 18 7 .16 + 44.22 1.06E-10 1.68E-08 xenobiotic metabolic process (GO:0006805) 133 13 1.17 + 11.11 1.74E-10 2.72E-08 regulation of lipid metabolic process (GO:0019216) 341 19 3.00 + 6.34 1.90E-10 2.91E-08 fatty acid beta-oxidation using acyl-CoA dehydrogenase (GO:0033539) 11 6 .10 + 62.02 1.90E-10 2.93E-08 xenobiotic catabolic process (GO:0042178) 31 8 .27 + 29.34 2.03E-10 3.08E-08 malonyl-CoA metabolic process (GO:2001293) 6 5 .05 + 94.75 2.97E-10 4.44E-08 Unclassified (UNCLASSIFIED) 2741 1 24.11 - .04 3.25E-10 4.77E-08 biological_process (GO:0008150) 17839 180 156.89 + 1.15 3.25E-10 4.82E-08 regulation of fatty acid oxidation (GO:0046320) 34 8 .30 + 26.75 4.58E-10 6.65E-08 succinyl-CoA metabolic process (GO:0006104) 13 6 .11 + 52.48 6.94E-10 9.99E-08 steroid biosynthetic process (GO:0006694) 95 11 .84 + 13.17 7.39E-10 1.05E-07 response to toxic substance (GO:0009636) 255 16 2.24 + 7.13 1.00E-09 1.41E-07 short-chain fatty acid catabolic process (GO:0019626) 7 5 .06 + 81.22 1.03E-09 1.43E-07 leukotriene catabolic process (GO:0036100) 7 5 .06 + 81.22 1.03E-09 1.44E-07 positive regulation of lipid localization (GO:1905954) 99 11 .87 + 12.63 1.16E-09 1.59E-07 fatty acid transmembrane transport (GO:1902001) 14 6 .12 + 48.73 1.21E-09 1.64E-07 regulation of lipid localization (GO:1905952) 156 13 1.37 + 9.48 1.27E-09 1.71E-07 carboxylic acid transport (GO:0046942) 300 17 2.64 + 6.44 1.40E-09 1.85E-07 organic acid transport (GO:0015849) 300 17 2.64 + 6.44 1.40E-09 1.86E-07 cellular response to xenobiotic stimulus (GO:0071466) 191 14 1.68 + 8.33 1.56E-09 2.05E-07 nucleobase-containing compound metabolic process (GO:0006139) 2745 55 24.14 + 2.28 1.82E-09 2.36E-07 lipid transport (GO:0006869) 355 18 3.12 + 5.77 2.63E-09 3.38E-07 lipid localization (GO:0010876) 356 18 3.13 + 5.75 2.75E-09 3.47E-07 hepoxilin biosynthetic process (GO:0051122) 8 5 .07 + 71.06 2.73E-09 3.48E-07 positive regulation of lipid transport (GO:0032370) 83 10 .73 + 13.70 3.01E-09 3.78E-07 regulation of fatty acid metabolic process (GO:0019217) 109 11 .96 + 11.47 3.26E-09 4.05E-07 estrogen metabolic process (GO:0008210) 45 8 .40 + 20.21 5.01E-09 6.17E-07 regulation of ketone metabolic process (GO:0010565) 143 12 1.26 + 9.54 5.19E-09 6.34E-07 carnitine shuttle (GO:0006853) 4 4 .04 + > 100 5.79E-09 6.95E-07 lipoxin biosynthetic process (GO:2001301) 4 4 .04 + > 100 5.79E-09 7.01E-07 long-chain fatty acid catabolic process (GO:0042758) 9 5 .08 + 63.17 6.10E-09 7.21E-07 icosanoid catabolic process (GO:1901523) 9 5 .08 + 63.17 6.10E-09 7.26E-07 regulation of fatty acid transport (GO:2000191) 31 7 .27 + 25.67 7.97E-09 9.35E-07 regulation of macromolecule metabolic process (GO:0060255) 5789 19 50.91 - .37 9.66E-09 1.12E-06 regulation of cold-induced thermogenesis (GO:0120161) 152 12 1.34 + 8.98 1.04E-08 1.20E-06 modified amino acid metabolic process (GO:0006575) 186 13 1.64 + 7.95 1.09E-08 1.24E-06 isoprenoid metabolic process (GO:0006720) 124 11 1.09 + 10.09 1.28E-08 1.45E-06 acetyl-CoA metabolic process (GO:0006084) 33 7 .29 + 24.12 1.28E-08 1.45E-06 regulation of RNA metabolic process (GO:0051252) 3702 7 32.56 - .21 1.45E-08 1.62E-06 alcohol metabolic process (GO:0006066) 313 16 2.75 + 5.81 1.87E-08 2.08E-06 positive regulation of fatty acid transport (GO:2000193) 21 6 .18 + 32.49 2.07E-08 2.28E-06 regulation of lipid transport (GO:0032368) 133 11 1.17 + 9.40 2.67E-08 2.92E-06 menaquinone catabolic process (GO:0042361) 5 4 .04 + 90.96 2.87E-08 3.09E-06 leukotriene B4 metabolic process (GO:0036102) 5 4 .04 + 90.96 2.87E-08 3.12E-06 regulation of RNA biosynthetic process (GO:2001141) 3405 6 29.95 - .20 2.98E-08 3.19E-06 regulation of DNA-templated transcription (GO:0006355) 3393 6 29.84 - .20 3.02E-08 3.21E-06 positive regulation of lipid metabolic process (GO:0045834) 136 11 1.20 + 9.20 3.37E-08 3.55E-06 positive regulation of fatty acid metabolic process (GO:0045923) 40 7 .35 + 19.90 5.29E-08 5.53E-06 sterol metabolic process (GO:0016125) 143 11 1.26 + 8.75 5.67E-08 5.89E-06 vitamin K metabolic process (GO:0042373) 13 5 .11 + 43.73 6.05E-08 6.24E-06 terpenoid metabolic process (GO:0006721) 115 10 1.01 + 9.89 7.25E-08 7.42E-06 bile acid metabolic process (GO:0008206) 42 7 .37 + 18.95 7.54E-08 7.66E-06 regulation of transcription by RNA polymerase II (GO:0006357) 2652 3 23.32 - .13 7.87E-08 7.94E-06 phylloquinone catabolic process (GO:0042376) 6 4 .05 + 75.80 8.56E-08 8.35E-06 vitamin K catabolic process (GO:0042377) 6 4 .05 + 75.80 8.56E-08 8.41E-06 menaquinone metabolic process (GO:0009233) 6 4 .05 + 75.80 8.56E-08 8.47E-06 medium-chain fatty-acyl-CoA metabolic process (GO:0036112) 6 4 .05 + 75.80 8.56E-08 8.53E-06 fatty-acyl-CoA catabolic process (GO:0036115) 6 4 .05 + 75.80 8.56E-08 8.58E-06 response to xenobiotic stimulus (GO:0009410) 400 17 3.52 + 4.83 9.77E-08 9.47E-06 ketone metabolic process (GO:0042180) 90 9 .79 + 11.37 9.88E-08 9.51E-06 bile acid biosynthetic process (GO:0006699) 27 6 .24 + 25.27 1.08E-07 1.03E-05 regulation of nucleobase-containing compound metabolic process (GO:0019219) 4005 10 35.22 - .28 1.26E-07 1.19E-05 organic anion transport (GO:0015711) 408 17 3.59 + 4.74 1.30E-07 1.22E-05 fatty acid alpha-oxidation (GO:0001561) 7 4 .06 + 64.97 1.98E-07 1.86E-05 regulation of small molecule metabolic process (GO:0062012) 337 15 2.96 + 5.06 3.18E-07 2.97E-05 positive regulation of cold-induced thermogenesis (GO:0120162) 104 9 .91 + 9.84 3.46E-07 3.20E-05 coenzyme A metabolic process (GO:0015936) 18 5 .16 + 31.58 3.89E-07 3.58E-05 nucleobase-containing compound biosynthetic process (GO:0034654) 1736 37 15.27 + 2.42 4.65E-07 4.25E-05 regulation of gene expression (GO:0010468) 4973 17 43.74 - .39 4.69E-07 4.26E-05 regulation of icosanoid secretion (GO:0032303) 19 5 .17 + 29.92 5.24E-07 4.73E-05 cellular oxidant detoxification (GO:0098869) 81 8 .71 + 11.23 5.71E-07 5.12E-05 lactone catabolic process (GO:1901335) 3 3 .03 + > 100 6.69E-07 5.89E-05 carnitine metabolic process, CoA-linked (GO:0019254) 3 3 .03 + > 100 6.69E-07 5.93E-05 lipoxin A4 biosynthetic process (GO:2001303) 3 3 .03 + > 100 6.69E-07 5.97E-05 regulation of lipid biosynthetic process (GO:0046890) 194 11 1.71 + 6.45 1.23E-06 1.07E-04 positive regulation of organic acid transport (GO:0032892) 41 6 .36 + 16.64 1.48E-06 1.29E-04 intracellular lipid transport (GO:0032365) 42 6 .37 + 16.24 1.72E-06 1.49E-04 diterpenoid metabolic process (GO:0016101) 96 8 .84 + 9.48 2.10E-06 1.81E-04 regulation of macromolecule biosynthetic process (GO:0010556) 5083 19 44.70 - .43 2.19E-06 1.88E-04 regulation of organic acid transport (GO:0032890) 69 7 .61 + 11.53 2.47E-06 2.09E-04 primary alcohol metabolic process (GO:0034308) 98 8 .86 + 9.28 2.46E-06 2.09E-04 methyl-branched fatty acid metabolic process (GO:0097089) 4 3 .04 + 85.28 2.66E-06 2.18E-04 leukotriene B4 catabolic process (GO:0036101) 4 3 .04 + 85.28 2.66E-06 2.20E-04 medium-chain fatty-acyl-CoA catabolic process (GO:0036114) 4 3 .04 + 85.28 2.66E-06 2.21E-04 long-chain fatty acid import into cell (GO:0044539) 12 4 .11 + 37.90 2.71E-06 2.21E-04 malonyl-CoA catabolic process (GO:2001294) 4 3 .04 + 85.28 2.66E-06 2.22E-04 arachidonate metabolite production involved in inflammatory response (GO:0002538) 4 3 .04 + 85.28 2.66E-06 2.23E-04 hormone metabolic process (GO:0042445) 224 11 1.97 + 5.58 4.94E-06 4.01E-04 fat-soluble vitamin catabolic process (GO:0042363) 14 4 .12 + 32.49 5.41E-06 4.34E-04 hydrogen peroxide biosynthetic process (GO:0050665) 14 4 .12 + 32.49 5.41E-06 4.37E-04 regulation of fatty acid biosynthetic process (GO:0042304) 52 6 .46 + 13.12 6.20E-06 4.95E-04 epoxide metabolic process (GO:0097176) 5 3 .04 + 68.22 6.61E-06 5.25E-04 positive regulation of fatty acid oxidation (GO:0046321) 15 4 .13 + 30.32 7.32E-06 5.79E-04 detoxification (GO:0098754) 154 9 1.35 + 6.64 9.15E-06 7.19E-04 cellular detoxification (GO:1990748) 117 8 1.03 + 7.77 9.25E-06 7.23E-04 vitamin catabolic process (GO:0009111) 16 4 .14 + 28.43 9.70E-06 7.50E-04 lipid import into cell (GO:0140354) 16 4 .14 + 28.43 9.70E-06 7.54E-04 positive regulation of small molecule metabolic process (GO:0062013) 156 9 1.37 + 6.56 1.01E-05 7.81E-04 cytoskeleton organization (GO:0007010) 1311 0 11.53 - < 0.01 1.03E-05 7.88E-04 establishment of skin barrier (GO:0061436) 34 5 .30 + 16.72 1.13E-05 8.57E-04 ceramide biosynthetic process (GO:0046513) 58 6 .51 + 11.76 1.18E-05 8.93E-04 ketone catabolic process (GO:0042182) 17 4 .15 + 26.75 1.26E-05 9.44E-04 positive regulation of icosanoid secretion (GO:0032305) 17 4 .15 + 26.75 1.26E-05 9.49E-04 monoterpenoid metabolic process (GO:0016098) 6 3 .05 + 56.85 1.31E-05 9.68E-04 hydrogen peroxide metabolic process (GO:0042743) 35 5 .31 + 16.24 1.30E-05 9.73E-04 succinyl-CoA biosynthetic process (GO:1901290) 6 3 .05 + 56.85 1.31E-05 9.73E-04 cholesterol metabolic process (GO:0008203) 123 8 1.08 + 7.40 1.34E-05 9.80E-04 regulation of fatty acid beta-oxidation (GO:0031998) 18 4 .16 + 25.27 1.61E-05 1.17E-03 cellular response to toxic substance (GO:0097237) 129 8 1.13 + 7.05 1.89E-05 1.37E-03 glutathione metabolic process (GO:0006749) 64 6 .56 + 10.66 2.09E-05 1.51E-03 regulation of cellular process (GO:0050794) 11547 73 101.56 - .72 2.21E-05 1.59E-03 lipid hydroxylation (GO:0002933) 7 3 .06 + 48.73 2.28E-05 1.63E-03 very long-chain fatty acid catabolic process (GO:0042760) 7 3 .06 + 48.73 2.28E-05 1.63E-03 secondary alcohol metabolic process (GO:1902652) 134 8 1.18 + 6.79 2.49E-05 1.76E-03 nucleic acid metabolic process (GO:0090304) 2180 4 19.17 - .21 2.74E-05 1.93E-03 macromolecule metabolic process (GO:0043170) 5431 24 47.77 - .50 2.78E-05 1.95E-03 carboxylic acid transmembrane transport (GO:1905039) 139 8 1.22 + 6.54 3.24E-05 2.26E-03 signal transduction (GO:0007165) 4926 21 43.32 - .48 3.45E-05 2.40E-03 cellular component organization or biogenesis (GO:0071840) 6059 29 53.29 - .54 3.66E-05 2.53E-03 response to nutrient levels (GO:0031667) 506 15 4.45 + 3.37 4.34E-05 2.98E-03 regulation of hormone levels (GO:0010817) 567 16 4.99 + 3.21 4.33E-05 2.98E-03 benzene-containing compound metabolic process (GO:0042537) 23 4 .20 + 19.77 4.50E-05 3.07E-03 positive regulation of macromolecule metabolic process (GO:0010604) 3187 10 28.03 - .36 4.77E-05 3.24E-03 response to nutrient (GO:0007584) 147 8 1.29 + 6.19 4.83E-05 3.27E-03 cell communication (GO:0007154) 5314 24 46.74 - .51 5.25E-05 3.53E-03 response to nematode (GO:0009624) 9 3 .08 + 37.90 5.41E-05 3.59E-03 positive regulation of fatty acid biosynthetic process (GO:0045723) 24 4 .21 + 18.95 5.36E-05 3.59E-03 response to selenium ion (GO:0010269) 9 3 .08 + 37.90 5.41E-05 3.60E-03 secondary metabolic process (GO:0019748) 47 5 .41 + 12.10 5.66E-05 3.74E-03 reactive oxygen species biosynthetic process (GO:1903409) 25 4 .22 + 18.19 6.34E-05 4.15E-03 mitochondrial transmembrane transport (GO:1990542) 25 4 .22 + 18.19 6.34E-05 4.17E-03 cellular response to chemical stimulus (GO:0070887) 1989 35 17.49 + 2.00 6.54E-05 4.27E-03 anatomical structure morphogenesis (GO:0009653) 2287 5 20.11 - .25 6.65E-05 4.32E-03 signaling (GO:0023052) 5270 24 46.35 - .52 7.22E-05 4.66E-03 negative regulation of macromolecule metabolic process (GO:0010605) 2641 7 23.23 - .30 7.31E-05 4.70E-03 positive regulation of long-chain fatty acid import across plasma membrane (GO:0010747) 2 2 .02 + > 100 7.69E-05 4.74E-03 very long-chain fatty-acyl-CoA metabolic process (GO:0036111) 2 2 .02 + > 100 7.69E-05 4.76E-03 oxylipin metabolic process (GO:0031407) 2 2 .02 + > 100 7.69E-05 4.78E-03 oxylipin biosynthetic process (GO:0031408) 2 2 .02 + > 100 7.69E-05 4.80E-03 leukotriene A4 metabolic process (GO:1901751) 2 2 .02 + > 100 7.69E-05 4.82E-03 phytol metabolic process (GO:0033306) 2 2 .02 + > 100 7.69E-05 4.84E-03 malonyl-CoA biosynthetic process (GO:2001295) 2 2 .02 + > 100 7.69E-05 4.86E-03 lipoxin B4 metabolic process (GO:2001304) 2 2 .02 + > 100 7.69E-05 4.88E-03 fatty alcohol metabolic process (GO:1903173) 2 2 .02 + > 100 7.69E-05 4.90E-03 leukotriene production involved in inflammatory response (GO:0002540) 2 2 .02 + > 100 7.69E-05 4.93E-03 oxidative demethylation (GO:0070989) 11 3 .10 + 31.01 1.05E-04 6.40E-03 glutathione catabolic process (GO:0006751) 11 3 .10 + 31.01 1.05E-04 6.43E-03 positive regulation of RNA metabolic process (GO:0051254) 1838 3 16.17 - .19 1.06E-04 6.44E-03 cellular component organization (GO:0016043) 5846 29 51.42 - .56 1.26E-04 7.62E-03 retinol metabolic process (GO:0042572) 56 5 .49 + 10.15 1.32E-04 7.98E-03 mitochondrial transport (GO:0006839) 92 6 .81 + 7.42 1.62E-04 9.75E-03 RNA metabolic process (GO:0016070) 1523 2 13.39 - .15 1.68E-04 1.00E-02 regulation of protein metabolic process (GO:0051246) 1550 2 13.63 - .15 1.71E-04 1.02E-02 vitamin metabolic process (GO:0006766) 32 4 .28 + 14.21 1.72E-04 1.02E-02 regulation of heat generation (GO:0031650) 13 3 .11 + 26.24 1.79E-04 1.05E-02 regulation of prostaglandin secretion (GO:0032306) 13 3 .11 + 26.24 1.79E-04 1.06E-02 ether biosynthetic process (GO:1901503) 13 3 .11 + 26.24 1.79E-04 1.06E-02 steroid hormone biosynthetic process (GO:0120178) 33 4 .29 + 13.78 1.94E-04 1.13E-02 cell surface receptor signaling pathway (GO:0007166) 2140 5 18.82 - .27 1.94E-04 1.13E-02 dicarboxylic acid metabolic process (GO:0043648) 96 6 .84 + 7.11 2.05E-04 1.19E-02 positive regulation of DNA-templated transcription (GO:0045893) 1708 3 15.02 - .20 2.14E-04 1.23E-02 positive regulation of RNA biosynthetic process (GO:1902680) 1710 3 15.04 - .20 2.14E-04 1.23E-02 modified amino acid catabolic process (GO:0042219) 34 4 .30 + 13.38 2.18E-04 1.25E-02 positive regulation of lipid biosynthetic process (GO:0046889) 98 6 .86 + 6.96 2.30E-04 1.25E-02 ceramide metabolic process (GO:0006672) 98 6 .86 + 6.96 2.30E-04 1.26E-02 lauric acid metabolic process (GO:0048252) 3 2 .03 + 75.80 2.29E-04 1.26E-02 negative regulation of icosanoid secretion (GO:0032304) 3 2 .03 + 75.80 2.29E-04 1.27E-02 positive regulation of long-chain fatty acid import into cell (GO:0140214) 3 2 .03 + 75.80 2.29E-04 1.27E-02 butyryl-CoA catabolic process (GO:0044580) 3 2 .03 + 75.80 2.29E-04 1.28E-02 leukotriene D4 catabolic process (GO:1901749) 3 2 .03 + 75.80 2.29E-04 1.28E-02 sesquiterpenoid metabolic process (GO:0006714) 3 2 .03 + 75.80 2.29E-04 1.29E-02 dibenzo-p-dioxin metabolic process (GO:0018894) 3 2 .03 + 75.80 2.29E-04 1.29E-02 negative regulation of fatty acid oxidation (GO:0046322) 14 3 .12 + 24.36 2.27E-04 1.29E-02 endocannabinoid signaling pathway (GO:0071926) 3 2 .03 + 75.80 2.29E-04 1.30E-02 pressure natriuresis (GO:0003095) 3 2 .03 + 75.80 2.29E-04 1.30E-02 organelle organization (GO:0006996) 3146 11 27.67 - .40 2.40E-04 1.31E-02 microtubule-based process (GO:0007017) 954 0 8.39 - < 0.01 2.82E-04 1.52E-02 lactone metabolic process (GO:1901334) 15 3 .13 + 22.74 2.82E-04 1.52E-02 negative regulation of macromolecule biosynthetic process (GO:0010558) 2259 6 19.87 - .30 2.84E-04 1.52E-02 demethylation (GO:0070988) 15 3 .13 + 22.74 2.82E-04 1.53E-02 response to chemical (GO:0042221) 3741 53 32.90 + 1.61 2.98E-04 1.59E-02 regulation of lipid catabolic process (GO:0050994) 67 5 .59 + 8.49 3.09E-04 1.65E-02 dicarboxylic acid catabolic process (GO:0043649) 16 3 .14 + 21.32 3.44E-04 1.82E-02 olefinic compound biosynthetic process (GO:0120255) 16 3 .14 + 21.32 3.44E-04 1.83E-02 reactive oxygen species metabolic process (GO:0072593) 106 6 .93 + 6.44 3.51E-04 1.85E-02 intracellular protein localization (GO:0008104) 1875 4 16.49 - .24 3.65E-04 1.92E-02 acylglycerol metabolic process (GO:0006639) 107 6 .94 + 6.38 3.69E-04 1.93E-02 neutral lipid metabolic process (GO:0006638) 108 6 .95 + 6.32 3.88E-04 2.02E-02 fatty acid homeostasis (GO:0055089) 17 3 .15 + 20.06 4.15E-04 2.15E-02 toxin metabolic process (GO:0009404) 17 3 .15 + 20.06 4.15E-04 2.16E-02 propionyl-CoA metabolic process (GO:1902858) 4 2 .04 + 56.85 4.56E-04 2.32E-02 coenzyme A catabolic process (GO:0015938) 4 2 .04 + 56.85 4.56E-04 2.33E-02 response to symbiotic bacterium (GO:0009609) 4 2 .04 + 56.85 4.56E-04 2.33E-02 negative regulation of germ cell proliferation (GO:1905937) 4 2 .04 + 56.85 4.56E-04 2.34E-02 negative regulation of male germ cell proliferation (GO:2000255) 4 2 .04 + 56.85 4.56E-04 2.35E-02 negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 1656 3 14.56 - .21 4.67E-04 2.36E-02 regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358) 18 3 .16 + 18.95 4.95E-04 2.50E-02 immune response (GO:0006955) 1802 4 15.85 - .25 5.06E-04 2.54E-02 negative regulation of DNA-templated transcription (GO:0045892) 1395 2 12.27 - .16 5.19E-04 2.60E-02 negative regulation of RNA biosynthetic process (GO:1902679) 1404 2 12.35 - .16 5.22E-04 2.61E-02 sterol biosynthetic process (GO:0016126) 43 4 .38 + 10.58 5.46E-04 2.72E-02 hormone biosynthetic process (GO:0042446) 44 4 .39 + 10.34 5.97E-04 2.96E-02 macromolecule biosynthetic process (GO:0009059) 2970 11 26.12 - .42 6.10E-04 3.02E-02 cellular response to calcium ion (GO:0071277) 79 5 .69 + 7.20 6.63E-04 3.27E-02 response to cold (GO:0009409) 46 4 .40 + 9.89 7.08E-04 3.48E-02 immune system process (GO:0002376) 2457 8 21.61 - .37 7.48E-04 3.66E-02 regulation of germ cell proliferation (GO:1905936) 5 2 .04 + 45.48 7.56E-04 3.66E-02 RNA biosynthetic process (GO:0032774) 1350 2 11.87 - .17 7.52E-04 3.67E-02 regulation of male germ cell proliferation (GO:2000254) 5 2 .04 + 45.48 7.56E-04 3.67E-02 regulation of biological process (GO:0050789) 11979 83 105.35 - .79 8.35E-04 4.02E-02 macromolecule catabolic process (GO:0009057) 1146 1 10.08 - .10 8.32E-04 4.02E-02 negative regulation of RNA metabolic process (GO:0051253) 1530 3 13.46 - .22 9.12E-04 4.34E-02 regulation of cellular response to oxidative stress (GO:1900407) 22 3 .19 + 15.50 9.11E-04 4.36E-02 production of molecular mediator involved in inflammatory response (GO:0002532) 22 3 .19 + 15.50 9.11E-04 4.37E-02 regulation of cell development (GO:0060284) 826 0 7.26 - < 0.01 9.56E-04 4.54E-02 post-translational protein modification (GO:0043687) 837 0 7.36 - < 0.01 9.63E-04 4.56E-02 gene expression (GO:0010467) 2582 9 22.71 - .40 9.73E-04 4.59E-02 monoatomic ion transmembrane transport (GO:0034220) 860 0 7.56 - < 0.01 1.03E-03 4.82E-02