SIR2_SCHPO/164-380       GAGISTSLGILDFRS.DNGFYARLARHG..LSEPSEMFDIHTFRENPEIFYTFARDLLPE..TNHYSPSHAFIRLLEKKN.KLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIR..NQRVS..............................YCNECGKPPLKLRRVGQNKKEKHY.FSDGDSESSEDDLAQPGIMKPDITFFGEALPDSFFNKVGSGELEETDLLICIGTSLKVAP
SIR2_CANAL/246-437       GAGISTSLGIPDFRS.FKGLYNQLSKLN..LSDPQKVFDLQTFMREPGLFYTIAHLVLPP..DGKFSLLHAFLKLLQDKH.KLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAKCVSCQGIFAGEKIYNHIR..RKQVP..............................RCAICWKNTKQA.........................PIHFGAIKPTITFFGEDLP.ERFHTLMDKDLQQIDLFLVIGTSLKVEP
SIR2_KLULA/318-534       GAGISTSLGIPDFRS.SEGFYSKLGDLG..LNDPQDVFSLEVFTEDPSVFYNIAHMVLPP..ENMYSPLHSFIKMIQDKD.KLLRNYTQNIDNLESYAGVEPEKMVQCHGSFATASCVTCHWKIQGERIFPNIR..NLQLP..............................ICPYCYSKRLEFFKTKTDEELADGEDDDMDDHHGRSVPKSFGVLKPDITFFGEALP.SKFHRLIREDVLQCDLLICIGTSLKVAP
SIR2_YEAST/262-478       GAGVSTSLGIPDFRS.SEGFYSKIKHLG..LDDPQDVFNYNIFMHDPSVFYNIANMVLPP..EKIYSPLHSFIKMLQMKG.KLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIR..NLELP..............................LCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALP.NKFHKSIREDILECDLLICIGTSLKVAP
SIRT1_DROME/229-434      GAGVSVSCGIPDFRS.TNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPG..EFQPSPCHRFIKMLETKG.KLLRNYTQNIDTLERVAGIQ..RVIECHGSFSTASCTKCRFKCNADALRADIF..AQRIP..............................VCPQCQPNKEQSVDASVAV...........TEEELRQLVENGIMKPDIVFFGEGLP.DEYHTVMATDKDVCDLLIVIGSSLKVRP
SIR2_CAEEL/153-334       GAGVSVSCGIPDFRS.KDGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPG..QFVPSVSHRFIKELETSG.RLLRNYTQNIDTLEHQTGIK..RVVECHGSFSKCTCTRCGQKYDGNEIREEVL..AMRVA..............................HCKRC..E.................................GVIKPNIVFFGEDLG.REFHQHVTEDKHKVDLIVVIGSSLKVRP
NPD_BACSU/19-198         GAGMSTESGIPDFRS.AGGIWTEDASRM.EAMSLDYFLSYPRLFWP..KFKELFQMKMSG..SFEPNEGHLLLAELEKQG.KQVDIFTQNIDGLHKKAGSR..HVYELHGSIQTAACPACGARYDLPHLLEREV..PECTAA...........................GNNGDICGT...................................VLKTDVVLFGDAVM..HFDTLYE.KLDQADLLLVIGTSLEVAP
NPD_ECOLI/48-221         GAGISAESGIRTFRA.ADGLWEEHRVED..VATPEGFDRDPELVQA...FYNARRRQLQQ.PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT..NVIHMHGELLKVRCSQSGQVLDW...TGDVT..PEDKC..............................HCCQFPA...................................PLRPHVVWFGEMPL..GMDEIYM.ALSMADIFIAIGTSGHVYP
NPD_MYCTU/8-184          GAGISAESGVPTFRDDKNGLWARFDPYE..LSSTQGWLRNPERVWG...WYLWRHYLVA...NVEPNDGHRAIAAWQDHA..EVSVITQNVDDLHERAGSG..AVHHLHGSLFEFRCARCGVPYTD.ALPEMPEPAIEVEP..............................PVCDCGG...................................LIRPDIVWFGEPLPEEPWRSAVE.ATGSADVMVVVGTSAIVYP
NPD1_ARCFU/20-192        GAGVSAESGIPTFR.GKDGLWNRYRPEE..LANPQAFAKDPEKVWK...WYAWRMEKVFN...AQPNKAHQAFAELERLG.VLKCLITQNVDDLHERAGSR..NVIHLHGSLRVVRCTSCNNSFEVESAPKIPP..LP.................................KCDKCGS...................................LLRPGVVWFGEMLPPDVLDRAMR.EVERADVIIVAGTSAVVQP
NPD2_ARCFU/23-198        GAGISAESGIPTFR.GEDGLWRKYDPEE..VASISGFKRNPRAFWE...FSMEMKDKLF....AEPNPAHYAIAELERMG.IVKAVITQNIDMLHQRAGSR..RVLELHGSMDKLDCLDCHE..TYDWSEFVED..FNKG.E...........................IPRCRKCGS..................................YYVKPRVVLFGEPLPQRTLFEAIE.EAKHCDAFMVVGSSLVVYP
NPD_AQUAE/11-183         GAGISAESGIPTFR.GKDGLWNKFKPEE..LATPEAFFRNPKLVWE...WYDWKRQLIAK...AQPNEGHKILTKMEEEF.PNFYLITQNVDGLHQRAGSK..KVIELHGNIWKVRCVECGN.ERYEYTTPLPE..IP................................PKCEKCGG...................................LLRPGVVWFGESLPVDALSRAYE.LSREAHVFIVVGTSGVVYP
NPD_STAA8/23-198         GAGVSVASGVPDFRS.MGGLFDEISKDG...LSPEYLLSRDYLEDDPEGFINFCHKRLLF.VDTMPNIVHDWIAKLERNQ.QSLGVITQNIDGLHSDAGSQ..HVDELHGTLNRFYCNVCHKSYTKSDVIDRTL..KH..................................CDNCGG...................................AIRPDIVLYGEMLDQPTIIRALN.KIEHADTLVVLGSSLVVQP
SIR42_CAEEL/35-243       GAGISTESGIPDYRSKDVGLYTKTALEP..IYFQDFMKSKKCRQRY...WSRSYLNWPRF.AQALPNFNHYALSKWEAAN.KFHWLITQNVDGLHLKAGSK..MITELHGNALQVKCTSCEYIETRQTYQDRLN..YANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECLNCGG...................................LMKTDVTLFGENLNTDKIKVCGK.KVNECNGVLTLGTSLEVLS
SIR41_CAEEL/35-243       GAGISTESGIPDYRSKDVGLYARIAHKP..IYFQDYMRSNRCRQRY...WSRNFLAWPRF.GQAAPNINHYALSKWEASD.RFQWLITQNVDGLHLKAGSK..MVTELHGSALQVKCTTCDYIESRQTYQDRLD..YANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGG...................................LMKTDVTFFGENVNMDKVNFCYE.KVNECDGILSLGTSLAVLS
HST2_CANAL/26-208        GAGISTGAGIPDFRSPDTGLYANLAKLN..LPFAEAVFDIDFFKEDPKPFYTLAEELYPG..NFAPTKFHHFIKLLQDQG.SLKRVYTQNIDTLERLAGVEDKYIVEAHGSFASNHCVDCHKEMTTETLKTYMK..DKKIP..............................SCQHCEG...................................YVKPDIVFFGEGLP.VKFFDLWEDDCEDVEVAIVAGTSLTVFP
SIR2_TRYB2/37-220        GAGISVAAGIPDFRSPHTGLYAKLSRYN..LNSPEDAFSLPLLRQQPSVFYNILMDMDLWPGKYCPTTVHHFISLLAKKG.MLLCCCTQNIDGLERACGIPESLLVEAHGSFSSASCVDCHAKYDINMARAETR..AGKVP..............................HCNQCGG...................................IVKPDVVFFGENLP.EAFFNVAG.LIEETELLLILGTSLQVHP
SIR2_LEIMA/39-223        GAGASVAAGIPDFRSSDTGIYAKLGKYN..LDDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEG.RLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAM..SGTVS..............................RCSTCGG...................................IVKPNVVFFGENLP.DAFFDALHHDAPIAELVIIIGTSMQVHP