>SIR2_SCHPO/164-380
GAGISTSLGILDFRS-DNGFYARLARHG--LSEPSEMFDIHTFRENPEIFYTFARDLLPE--TNHYSPSHAF
IRLLEKKN-KLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIR--NQRVS---
---------------------------YCNECGKPPLKLRRVGQNKKEKHY-FSDGDSESSEDDLAQPGIMK
PDITFFGEALPDSFFNKVGSGELEETDLLICIGTSLKVAP
>SIR2_CANAL/246-437
GAGISTSLGIPDFRS-FKGLYNQLSKLN--LSDPQKVFDLQTFMREPGLFYTIAHLVLPP--DGKFSLLHAF
LKLLQDKH-KLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAKCVSCQGIFAGEKIYNHIR--RKQVP---
---------------------------RCAICWKNTKQA-------------------------PIHFGAIK
PTITFFGEDLP-ERFHTLMDKDLQQIDLFLVIGTSLKVEP
>SIR2_KLULA/318-534
GAGISTSLGIPDFRS-SEGFYSKLGDLG--LNDPQDVFSLEVFTEDPSVFYNIAHMVLPP--ENMYSPLHSF
IKMIQDKD-KLLRNYTQNIDNLESYAGVEPEKMVQCHGSFATASCVTCHWKIQGERIFPNIR--NLQLP---
---------------------------ICPYCYSKRLEFFKTKTDEELADGEDDDMDDHHGRSVPKSFGVLK
PDITFFGEALP-SKFHRLIREDVLQCDLLICIGTSLKVAP
>SIR2_YEAST/262-478
GAGVSTSLGIPDFRS-SEGFYSKIKHLG--LDDPQDVFNYNIFMHDPSVFYNIANMVLPP--EKIYSPLHSF
IKMLQMKG-KLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIR--NLELP---
---------------------------LCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLK
PDITFFGEALP-NKFHKSIREDILECDLLICIGTSLKVAP
>SIRT1_DROME/229-434
GAGVSVSCGIPDFRS-TNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPG--EFQPSPCHRF
IKMLETKG-KLLRNYTQNIDTLERVAGIQ--RVIECHGSFSTASCTKCRFKCNADALRADIF--AQRIP---
---------------------------VCPQCQPNKEQSVDASVAV-----------TEEELRQLVENGIMK
PDIVFFGEGLP-DEYHTVMATDKDVCDLLIVIGSSLKVRP
>SIR2_CAEEL/153-334
GAGVSVSCGIPDFRS-KDGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPG--QFVPSVSHRF
IKELETSG-RLLRNYTQNIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYDGNEIREEVL--AMRVA---
---------------------------HCKRC--E---------------------------------GVIK
PNIVFFGEDLG-REFHQHVTEDKHKVDLIVVIGSSLKVRP
>HST2_CANAL/26-208
GAGISTGAGIPDFRSPDTGLYANLAKLN--LPFAEAVFDIDFFKEDPKPFYTLAEELYPG--NFAPTKFHHF
IKLLQDQG-SLKRVYTQNIDTLERLAGVEDKYIVEAHGSFASNHCVDCHKEMTTETLKTYMK--DKKIP---
---------------------------SCQHCEG-----------------------------------YVK
PDIVFFGEGLP-VKFFDLWEDDCEDVEVAIVAGTSLTVFP
>SIR2_TRYB2/37-220
GAGISVAAGIPDFRSPHTGLYAKLSRYN--LNSPEDAFSLPLLRQQPSVFYNILMDMDLWPGKYCPTTVHHF
ISLLAKKG-MLLCCCTQNIDGLERACGIPESLLVEAHGSFSSASCVDCHAKYDINMARAETR--AGKVP---
---------------------------HCNQCGG-----------------------------------IVK
PDVVFFGENLP-EAFFNVAG-LIEETELLLILGTSLQVHP
>SIR2_LEIMA/39-223
GAGASVAAGIPDFRSSDTGIYAKLGKYN--LDDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHF
IRLLQDEG-RLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAM--SGTVS---
---------------------------RCSTCGG-----------------------------------IVK
PNVVFFGENLP-DAFFDALHHDAPIAELVIIIGTSMQVHP
