RID: 3SNZ7W8G01N Job Title:tr|A0A833DZW1|A0A833DZW1_9EURY Reverse Program: BLASTP Query: tr|A0A833DZW1|A0A833DZW1_9EURY Reverse gyrase OS=Methanothermococcus okinawensis OX=155863 GN=rgy PE=3 SV=1 ID: lcl|Query_548258(amino acid) Length: 1112 Database: swissprot Non-redundant UniProtKB/SwissProt sequences Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Methanocaldo... NA 243232 1233 1660 99% 0.0 72.29 1613 Q58907.1 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Pyrococcus f... NA 186497 915 915 99% 0.0 43.75 1214 P95479.2 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Pyrococcus a... NA 272844 912 912 99% 0.0 43.53 1214 Q9UZ86.1 RecName: Full=Reverse gyrase 1; Includes: RecName:... Aquifex aeol... NA 224324 755 755 99% 0.0 40.52 1146 O67037.1 RecName: Full=Reverse gyrase 2; Includes: RecName:... Aquifex aeol... NA 224324 712 712 98% 0.0 39.46 1159 O67226.2 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Pyrobaculum ... NA 178306 699 699 99% 0.0 37.21 1228 Q8ZXT5.1 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Archaeoglobu... NA 224325 698 698 99% 0.0 39.05 1054 O29238.1 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Thermotoga m... NA 243274 679 679 98% 0.0 39.01 1104 O51934.1 RecName: Full=Reverse gyrase 1; Includes: RecName:... Saccharolobu... NA 273057 668 668 99% 0.0 38.09 1242 Q97ZZ8.1 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Thermococcus... NA 69014 663 914 99% 0.0 41.36 1711 Q6F598.1 RecName: Full=Reverse gyrase 2; Includes: RecName:... Sulfurisphae... NA 273063 662 662 98% 0.0 38.21 1233 Q975P6.2 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Sulfolobus a... NA 330779 660 660 98% 0.0 37.58 1248 Q08582.3 RecName: Full=Reverse gyrase 1; Includes: RecName:... Aeropyrum pe... NA 272557 658 658 99% 0.0 35.05 1370 Q9YCB6.2 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Pyrococcus h... NA 70601 656 916 99% 0.0 40.62 1624 O58530.1 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Caldanaeroba... NA 273068 646 646 98% 0.0 38.54 1117 Q8R979.1 RecName: Full=Reverse gyrase 2; Includes: RecName:... Aeropyrum pe... NA 272557 622 622 99% 0.0 34.75 1215 Q9YC75.2 RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase... Saccharolobu... NA 2286 600 600 99% 0.0 36.15 1166 P74759.1 RecName: Full=Reverse gyrase 2; Includes: RecName:... Saccharolobu... NA 273057 597 597 99% 0.0 36.48 1166 Q97ZF5.1 RecName: Full=Reverse gyrase 1; Includes: RecName:... Sulfurisphae... NA 273063 595 595 100% 0.0 37.75 1156 Q971T7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Thermotoga m... NA 243274 218 218 49% 5e-59 33.96 633 P46799.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Aquifex aeol... NA 224324 214 214 50% 2e-58 31.77 540 O66893.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Campylobacte... NA 192222 213 213 50% 9e-57 30.62 700 Q9PLZ2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 279808 209 209 50% 1e-55 30.54 689 Q4L5V2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 273036 206 206 50% 1e-54 30.57 689 Q2YXL8.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 176279 206 206 50% 1e-54 31.11 689 Q5HPU2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Fervidobacte... NA 2423 206 206 50% 2e-54 30.50 699 O34204.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 282459 206 206 50% 2e-54 30.57 689 Q6G9W3.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 1280 206 206 50% 2e-54 30.57 689 Q06AK7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 367830 204 204 50% 4e-54 30.57 689 Q2FHI8.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 342451 204 204 50% 8e-54 30.84 688 Q49X35.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Treponema pa... NA 243276 201 201 49% 9e-53 29.87 731 O83409.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Halalkalibac... NA 272558 201 201 50% 1e-52 28.83 690 Q9KA23.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pasteurella ... NA 272843 201 201 49% 8e-52 28.43 868 Q9CN30.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Haemophilus ... NA 71421 196 196 49% 2e-50 28.64 868 P43012.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pseudomonas ... NA 208964 195 195 50% 6e-50 29.21 868 Q9HZJ5.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Lactococcus ... NA 272623 192 192 50% 9e-50 29.53 710 Q9CG80.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Synechococcu... NA 1140 194 194 50% 1e-49 28.93 883 P34185.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Xylella fast... NA 183190 189 189 50% 3e-48 28.32 815 Q87AQ6.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Bacillus sub... NA 224308 187 187 50% 4e-48 28.90 691 P39814.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Xylella fast... NA 160492 188 188 50% 7e-48 28.32 815 Q9PEV8.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Synechocysti... NA 1111708 188 188 50% 1e-47 28.35 898 P73810.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Helicobacter... NA 85962 186 186 50% 1e-47 29.65 736 P55991.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Escherichia ... NA 83333 187 187 51% 2e-47 27.74 865 P06612.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Salmonella e... NA 99287 185 185 50% 6e-47 27.30 865 P0A2I1.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Vibrio chole... NA 243277 185 185 50% 8e-47 28.03 876 Q9KRB2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Zymomonas mo... NA 264203 186 186 50% 9e-47 28.16 1212 Q9X3X7.3 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Helicobacter... NA 85963 181 181 50% 4e-46 29.49 736 Q9ZMV7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia c... NA 272944 177 177 50% 1e-44 28.59 776 Q92IH1.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia b... NA 336407 175 175 50% 1e-43 29.30 800 Q1RIM1.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia f... NA 315456 174 174 50% 2e-43 28.75 776 Q4UM42.1 RecName: Full=DNA topoisomerase 1 type prokaryotic [Acanthamoe... Acanthamoeba... NA 212035 173 173 51% 4e-43 27.23 854 Q5UQB5.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pyrococcus a... NA 272844 170 170 50% 1e-42 29.24 685 Q9UYS8.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pyrococcus h... NA 70601 168 168 50% 6e-42 28.99 686 O58356.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia t... NA 257363 168 168 50% 1e-41 28.46 779 Q68X45.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia p... NA 272947 167 167 50% 3e-41 28.04 776 Q9ZDK2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycolicibact... NA 246196 166 166 49% 1e-40 27.15 936 A0R5D9.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycoplasmoid... NA 272634 161 161 50% 9e-40 27.06 711 P78032.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycobacteriu... NA 233413 162 162 49% 2e-39 27.22 934 P0A621.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Buchnera aph... NA 107806 162 162 50% 2e-39 27.99 861 P57371.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Methanocaldo... NA 243232 159 159 49% 8e-39 28.93 761 Q59046.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycoplasmoid... NA 243273 150 150 50% 4e-36 26.82 709 P47368.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Borreliella ... NA 224326 150 150 50% 1e-35 29.64 848 O51768.1 RecName: Full=DNA topoisomerase I, plasmid; AltName:... Xylella fast... NA 160492 148 148 50% 1e-35 27.80 660 Q9PHK2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Buchnera aph... NA 198804 148 148 40% 4e-35 29.84 853 Q8K9P7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Streptomyces... NA 100226 139 211 47% 3e-32 33.44 952 Q9X909.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycoplasmoid... NA 710127 138 138 50% 4e-32 26.56 719 Q9JN65.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycobacteriu... NA 272631 126 126 25% 4e-28 31.13 947 O69548.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Thermoplasma... NA 273075 119 119 41% 3e-26 26.43 770 Q9HM08.1 RecName: Full=DNA topoisomerase 3-alpha; AltName: Full=DNA... Drosophila m... fruit fly 7227 107 107 46% 2e-22 25.22 1250 Q9NG98.2 RecName: Full=DNA topoisomerase 3-alpha [Arabidopsis thaliana] Arabidopsis ... thale cress 3702 100 100 47% 5e-20 23.13 926 Q9LVP1.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Bacillus lic... NA 279010 87.0 87.0 47% 4e-16 24.92 727 Q65N90.2 RecName: Full=DNA topoisomerase 3-beta [Oryza sativa Japonica... Oryza sativa... Japanese rice 39947 86.7 86.7 50% 6e-16 23.44 866 Q0J0S6.1 RecName: Full=DNA topoisomerase 3-beta [Arabidopsis thaliana] Arabidopsis ... thale cress 3702 79.3 79.3 50% 1e-13 21.73 865 F4ISQ7.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Bacillus sub... NA 224308 77.0 77.0 47% 5e-13 23.85 727 P96583.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Escherichia ... NA 83333 68.9 68.9 35% 2e-10 24.39 653 P14294.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pyrococcus f... NA 186497 65.9 65.9 16% 2e-09 31.91 1060 O73954.2 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Salmonella e... NA 90370 63.5 63.5 35% 7e-09 23.87 649 Q8Z6F5.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Salmonella e... NA 99287 63.5 63.5 35% 8e-09 23.87 649 P40687.2 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Bacillus thu... NA 412694 62.4 62.4 35% 2e-08 22.83 729 A0R979.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Bacillus cer... NA 222523 62.0 62.0 35% 2e-08 22.62 729 Q73E74.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Bacillus cer... NA 288681 61.6 61.6 35% 3e-08 22.65 729 Q63GK5.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Vibrio chole... NA 243277 57.8 57.8 35% 5e-07 24.08 647 Q9KQF5.1 RecName: Full=DNA topoisomerase 3; AltName: Full=DNA... Haemophilus ... NA 71421 52.4 52.4 50% 2e-05 21.26 651 P43704.1 RecName: Full=UvrABC system protein B; Short=Protein UvrB;... Colwellia ps... NA 167879 44.3 44.3 23% 0.006 24.83 673 Q480C7.1 RecName: Full=Probable helicase HelY [Mycobacterium tuberculos... Mycobacteriu... NA 83331 42.7 42.7 11% 0.020 26.32 906 P9WMR0.1 Alignments: >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase; Contains: RecName: Full=Mja r-Gyr intein [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q58907.1 Length: 1613 Range 1: 1 to 866 Score:1233 bits(3190), Expect:0.0, Method:Compositional matrix adjust., Identities:626/866(72%), Positives:749/866(86%), Gaps:6/866(0%) Query 1 MIPIIYKEMCPNCFGEIYSSRLELGVCERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCK 60 MIP+IYKEMCPNC GEI S RL +GVCE+CL+EE KL LC KL ++K L LK YC Sbjct 1 MIPMIYKEMCPNCNGEITSERLAIGVCEKCLKEENVFEKLKLCEKLREEKTLKNLKDYCI 60 Query 61 VWNEFKKFDRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLADR 120 +WNEFK+F+ F K+LG+ELLSIQKMWAKRVLKNKSFSIV PTGVGKS FG+LMSL+LA + Sbjct 61 IWNEFKEFEEFVKDLGFELLSIQKMWAKRVLKNKSFSIVVPTGVGKSFFGILMSLFLAKK 120 Query 121 GKRCYIILPTTLLVKQTYERAQSLVGDN---IKVVCYHSELSEREKRDIKKRIEEGDFQV 177 GKRCYIILPTTLLVKQTYE+ SL N I+VV YHSELS +EK+++K+RIE D+ V Sbjct 121 GKRCYIILPTTLLVKQTYEKISSLTEKNNLNIRVVAYHSELSTKEKKEVKERIENNDYDV 180 Query 178 LITTSNYLTRNMPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKIILLMK 237 LITTSNYLT+NMP FDF+FVDDVDALLK+SKNIDRTL LLGF E+I+EAYKII L+K Sbjct 181 LITTSNYLTKNMPKCKFDFVFVDDVDALLKASKNIDRTLKLLGFDEEIINEAYKIIYLIK 240 Query 238 WRKFDKALELREKLRKKLEGIKHGCIVIASATGKSYGDKVKLYRELLNFEVGYGINKLRD 297 K + A++ RE L+KK+ IKHGC++IASATGKSYGD+VKLYRELL+FE+G+G+NKLRD Sbjct 241 IGKIEDAMKKREILKKKISKIKHGCLIIASATGKSYGDRVKLYRELLDFEIGFGMNKLRD 300 Query 298 VVDVYDE-IDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLLRENNIKAKVVHSKDK 356 VVD+YDE ++K+LEY+KL G GG++FVS DYG+E A++IE L ENNIKAK++HSKDK Sbjct 301 VVDIYDEEFSKEKILEYIKLFGSGGIVFVSIDYGVEKAQEIEKYLLENNIKAKLIHSKDK 360 Query 357 EGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKFKLREYLEKVRKNR 416 +GF+DFR GKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPK K +L+EY+ +++ Sbjct 361 KGFDDFREGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRLKEYINSLKEKG 420 Query 417 KI--DIDIEGKSLEEIEDILKRDLKLRNFSIKVEDDEIYILIPDIKTYIQASGRTSRMTE 474 ++ DI+IEGK+ EEI I+ LK++NFS++ EDDE +LIPD+KTYIQASGRTSRMTE Sbjct 421 ELKEDINIEGKTEEEIRQIITEKLKIKNFSLRKEDDEYLLLIPDVKTYIQASGRTSRMTE 480 Query 475 FGLTKGVSILLVDHWKLFESIEKYMLFHYESEFKSAREVNFEELIKKIDEDREKIKLCMR 534 FGLTKG SI+LVD ++FE+++KYMLF YESEFK EVN EELIKKIDEDREKIK+ Sbjct 481 FGLTKGASIVLVDEKEIFEALKKYMLFMYESEFKRIDEVNLEELIKKIDEDREKIKVGRA 540 Query 535 RGKVPDILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHI 594 +GKVPD+LKS+LMVVESPNKARTIA+FFG+PS RKI NVYEVCIGD+NLIITASGGH+ Sbjct 541 KGKVPDLLKSVLMVVESPNKARTIANFFGKPSVRKINNRNVYEVCIGDLNLIITASGGHV 600 Query 595 FDLVTKEGYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCR 654 FDLVTKEG+YGVKIE+N+YIPIY +I+K+NGEQ TDQKD+EE++++L+EKGE V ++ + Sbjct 601 FDLVTKEGFYGVKIENNLYIPIYTSIKKVNGEQFTDQKDLEELIKQLMEKGERVNAMDAK 660 Query 655 DNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRA 714 +N+E IREIADEVD +FIATDIDTEGEKIGYDI +N LPFNRNIYR+GFNEIT+RAIL+A Sbjct 661 ENIEIIREIADEVDAIFIATDIDTEGEKIGYDIAINALPFNRNIYRVGFNEITKRAILKA 720 Query 715 VEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWI 774 VE++++GEEL LDENKVK Q+VRRIEDRWIGF+LS+KLWEVF KNYLSAGRVQTPVLGWI Sbjct 721 VESFKKGEELSLDENKVKGQVVRRIEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWI 780 Query 775 IERYEEHKKKVPYLSLKLEYDIYVGKIWEGDFKGEEVEVEVNLYSRDISPSPPFTTDTLL 834 IERY EHK KVPYLSLKLE DIY+GKIWE +F +EVEVEV +Y ++I P PPFTTDTLL Sbjct 781 IERYNEHKIKVPYLSLKLENDIYIGKIWEDEFDKDEVEVEVKVYEKEIPPLPPFTTDTLL 840 Query 835 EEATKRFNLSTEEVMRIAQDLFELGL 860 EEATKRF LST+E+M IAQ+LFELGL Sbjct 841 EEATKRFGLSTDEIMSIAQELFELGL 866 Range 2: 1362 to 1605 Score:427 bits(1097), Expect:2e-126, Method:Compositional matrix adjust., Identities:205/244(84%), Positives:231/244(94%), Gaps:0/244(0%) Query 862 TYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFI 921 TYHRTSSTRVSL+GM+VAREYLKL+NLEDYLKNRE++MEG HECIRPTKPM+T ELIEF+ Sbjct 1362 TYHRTSSTRVSLDGMRVAREYLKLNNLEDYLKNREYFMEGAHECIRPTKPMNTDELIEFL 1421 Query 922 RENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDVEFDGWTRI 981 +ENNI L+KNHIK+YDLIFRRFIASQMKEA V YEE+YIKD+DE++EGYVD++FDGW+RI Sbjct 1422 KENNIKLTKNHIKVYDLIFRRFIASQMKEAVVEYEEIYIKDLDEKVEGYVDIKFDGWSRI 1481 Query 982 YNLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLL 1041 YNLKL+KLP+IEKS LKVLD +RK+ KVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLL Sbjct 1482 YNLKLKKLPRIEKSSLKVLDKKLRKIPKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLL 1541 Query 1042 DRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQV 1101 DRGYV+KSK+K KLIPTKLGIEVYNYLI +YPHLISEE+TRELEEIMDKIE GEVDYI+V Sbjct 1542 DRGYVVKSKDKNKLIPTKLGIEVYNYLINNYPHLISEERTRELEEIMDKIENGEVDYIEV 1601 Query 1102 LHAL 1105 L AL Sbjct 1602 LKAL 1605 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Pyrococcus furiosus DSM 3638] Sequence ID: P95479.2 Length: 1214 Range 1: 4 to 1204 Score:915 bits(2366), Expect:0.0, Method:Compositional matrix adjust., Identities:532/1216(44%), Positives:761/1216(62%), Gaps:130/1216(10%) Query 5 IYKEMCPNCFGEIYSSRLEL-GVCERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCKVWN 63 IY++MCPNC G I RL C+ CL+E S D + + +K KLKG K W Sbjct 4 IYRDMCPNCRGAITDERLAAKNPCDACLDEP--ISMDDYFQLVTAIRKALKLKGVLKEWE 61 Query 64 EFKKFDRFCKEL--------GYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSL 115 E ++ KE+ G+ S Q+ W KR++K KSFSI+APTG+GKS FG MS+ Sbjct 62 EIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSI 121 Query 116 YLADRGKRCYIILPTTLLVKQTYERAQSLVGD---NIKVVCYHSELSEREKRDIKKRIEE 172 Y A +GK+ YI++PTT LV QT ++ ++++ + +V YH L ++EK + ++I+ Sbjct 122 YFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKS 181 Query 173 GDFQVLITTSNYLTRN----MPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDE 228 G+F +L+T+S +L + DF+FVDDVDA LK+SKNIDR+L++LGF+ E+I + Sbjct 182 GNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKK 241 Query 229 AYKIILLMKWRKFDKALELREKLRKKLEGI---------------KHGCIVIASATGKSY 273 A++II L K E + +KL K G +++ASATG + Sbjct 242 AWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSAR 301 Query 274 GDKVKLYRELLNFEVGYGINKLRDVVDVY---DEIDRDKVLEYVKLLGPGGLIFVSQDYG 330 GD++KLYRELL FEVG G + LR++VD Y ++ + V E +K LG GGLIFV D G Sbjct 302 GDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKG 361 Query 331 LEVAKDIENLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERV 390 +E A+ + N L+ K ++V ++DK+G E F ++D L+GVA+YYG +VRGLD+P V Sbjct 362 IEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLV 421 Query 391 RYAIFYGIPKMKFKLR-----------------EYLEKVRKN---------RKIDIDIEG 424 R+AIF G+PK +F L E+L + ++ R++ +I Sbjct 422 RFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQ 481 Query 425 KSLEEIEDILKRDLKLRNF----------------------------------SIKVEDD 450 L +IE+ L L+L F S+K + Sbjct 482 YELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEG 541 Query 451 EIYILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHY-ESEFKS 509 + YI IPD++TYIQASGRTSR+ G+TKG+S++LVD K+F + + M + + E E K Sbjct 542 KWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKP 601 Query 510 AREVNFEELIKKIDEDREKIKLCMR---RGKVPDILKSILMVVESPNKARTIASFFGRPS 566 E+N EE++K+ID DREK++L + +V D++KS LM+VESPNKARTIA+FFG+PS Sbjct 602 LGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPS 661 Query 567 RRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYGV----KIEDNIYIPIYMAIRK 622 +R+I + YEV IGD L I ASGGH+FDLVT EGY+GV K ++P+Y I++ Sbjct 662 KRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKR 721 Query 623 IN--GEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEG 680 G Q D ++ + + + S V + +N++ +R++A EVD + I TD DTEG Sbjct 722 CRDCGHQFVDWEE-----KGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEG 776 Query 681 EKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIE 740 EKI +DI + P+ I RI F+E+TR AILRA+ R ++E++V +QLVRRIE Sbjct 777 EKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEAR-----DINEDRVNAQLVRRIE 831 Query 741 DRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEH-KKKVPYLSLKLEYDIYVG 799 DRWIGF+LS+KLWEVF+ LSAGRVQTPVLGWI++RY+E + + +L L LE DI + Sbjct 832 DRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITI- 890 Query 800 KIWEGDFKGEEVEV---EVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLF 856 I EG G+ EV EV + R+I+P PP+TTD +L++A++ S M++AQDLF Sbjct 891 -ILEG-VSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLF 948 Query 857 ELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGE 916 ELGLTTYHRT S VS G+++A+EY+ E+Y R++ EG HE IRPT+P+DTG Sbjct 949 ELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGR 1008 Query 917 LIEFIRENNISLSKN----HIKLYDLIFRRFIASQMKEATVVYEELYIKDI--DERIEGY 970 LI+ IR+ I+L +N H KLYDLIFRRF+ASQMK A V+YE I + IEGY Sbjct 1009 LIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGY 1068 Query 971 VDVEFDGWTRIYNLKLRKLPKIEKSK-LKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGR 1029 +DV +DGW+RI L L+KLP++EK + LKV + + KV LY +G+V+ LMKERGIGR Sbjct 1069 IDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGR 1128 Query 1030 PSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMD 1089 PSTYA+I++ LL RGYVI++K+K KL+PT+ GI+VY+YL++ Y L+SEE+TR+LE++MD Sbjct 1129 PSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMD 1188 Query 1090 KIERGEVDYIQVLHAL 1105 +E + +Y +VL+ L Sbjct 1189 MVEEAKANYQEVLNEL 1204 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Pyrococcus abyssi GE5] Sequence ID: Q9UZ86.1 Length: 1214 Range 1: 4 to 1204 Score:912 bits(2357), Expect:0.0, Method:Compositional matrix adjust., Identities:528/1213(44%), Positives:760/1213(62%), Gaps:124/1213(10%) Query 5 IYKEMCPNCFGEIYSSRL-ELGVCERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCKVWN 63 IY+ MCPNC G I RL E CE CL E + D + + + KL+G K W Sbjct 4 IYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAE--DYEKLVFAVRNALKLRGTLKDWE 61 Query 64 EFKKF--------DRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSL 115 + + D F + G+ S Q+ W KR+L+ KSFSI+APTG+GKS FG +S+ Sbjct 62 DLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISI 121 Query 116 YLADRGKRCYIILPTTLLVKQTYERAQSLV---GDNIKVVCYHSELSEREKRDIKKRIEE 172 Y A +GKR YI++PTT LV QT ++ Q ++ G N+++V YH L ++EK + KRI++ Sbjct 122 YFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKD 181 Query 173 GDFQVLITTSNYLTRN----MPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDE 228 GDF +L+T+S +L + FD IFVDDVDA LK+SKNIDR+LLLLGF++E+I+ Sbjct 182 GDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINR 241 Query 229 AYKIILLMKWRKFDKALELREKLRKKLEGIKH---------------GCIVIASATGKSY 273 A+++I L K + +EK ++L G +++ASATG + Sbjct 242 AWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSAR 301 Query 274 GDKVKLYRELLNFEVGYGINKLRDVVDVYDEIDR---DKVLEYVKLLGPGGLIFVSQDYG 330 GD++KLYRELL FEVG G + LR++VD Y +R ++V ++ LG GGLIFV D G Sbjct 302 GDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKG 361 Query 331 LEVAKDIENLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERV 390 +E A+++ N L+ K ++V +K+K G E F G++D L+GVA+YYG +VRGLD+P + Sbjct 362 IEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLI 421 Query 391 RYAIFYGIPKMKFKL-------------------------REYLEKV-RKNRKIDIDIEG 424 R+A+F G+PK +F + RE EK+ + R++ +I Sbjct 422 RFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQ 481 Query 425 KSLEEIEDILKRDLKLRNF----------------------------------SIKVEDD 450 L +IE+ L ++L F S+K + Sbjct 482 YELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEG 541 Query 451 EIYILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHY-ESEFKS 509 ++YI IPD++TYIQASGRTSR+ G+TKG+S+++VD K+F + + M + + E E K Sbjct 542 KLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKK 601 Query 510 AREVNFEELIKKIDEDREKIKLCMR---RGKVPDILKSILMVVESPNKARTIASFFGRPS 566 E+N E ++++IDEDR+K++L + +V D++KS LM+VESPNKARTIASFFG+PS Sbjct 602 FEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPS 661 Query 567 RRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYGVKIEDN----IYIPIYMAIRK 622 +R+I + YEV IGD L I ASGGH+FDLVT EGY+GV I + Y+P+Y I++ Sbjct 662 KRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKR 721 Query 623 IN--GEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEG 680 G Q D + + + K S V + +N++ +RE+A EVD + I TD DTEG Sbjct 722 CRDCGHQFVDWEQ-----KGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEG 776 Query 681 EKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIE 740 EKI +DI + P+ NI RI F+E+TR AIL+A++ R ++E++VK+QLVRRIE Sbjct 777 EKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEAR-----DINEDRVKAQLVRRIE 831 Query 741 DRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEH-KKKVPYLSLKLEYDIYVG 799 DRWIGF+LS+KLWEVF+ LSAGRVQTPVLGWI++RY+E + + +L L LE I + Sbjct 832 DRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISIT 891 Query 800 KIWEGDFKGEEVEVEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG 859 E +V + R+I+P PP+TTD +L++A++ S + M++AQDLFELG Sbjct 892 IENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELG 951 Query 860 LTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIE 919 L TYHRT S VS G+++A+EY+ E+Y R++ EG HE IRPT+P+DTG LI+ Sbjct 952 LCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQ 1011 Query 920 FIRENNISLSKN----HIKLYDLIFRRFIASQMKEATVVYEELYIKDI--DERIEGYVDV 973 IR+ I+L +N H +LYDLIFRRFIASQMK A V+YE+ I D +EGY+++ Sbjct 1012 LIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEI 1071 Query 974 EFDGWTRIYNLKLRKLPKIEKS-KLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPST 1032 +DGW+R+ L L+++PK+EK KLKV + + KV LY +G+V+ LMKERGIGRPST Sbjct 1072 LYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPST 1131 Query 1033 YAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 YA+I++ LL RGYVI++K + KL+PT+ GI+VY YL++ Y L+SEE+TR+LE+IMD+IE Sbjct 1132 YAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIE 1191 Query 1093 RGEVDYIQVLHAL 1105 + DY +VL L Sbjct 1192 EAKADYQEVLREL 1204 >RecName: Full=Reverse gyrase 1; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Aquifex aeolicus VF5] Sequence ID: O67037.1 Length: 1146 Range 1: 1 to 1134 Score:755 bits(1949), Expect:0.0, Method:Compositional matrix adjust., Identities:481/1187(41%), Positives:734/1187(61%), Gaps:135/1187(11%) Query 1 MIPIIYKEMCPNCFGEIYSSRLELGV-CERCLEEEERCSKLDLCRKLGDKKKLDKLKGYC 59 MI I+ +CPNC GEI + RL G+ CE+CL EE ++ ++C+KL + K +C Sbjct 1 MIKAIFDTLCPNCGGEISAERLLKGLPCEKCLPEE--VNREEVCQKLEN----GSFKEFC 54 Query 60 KVWNEFKKFDRFCKE-LGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLA 118 ++ +E K ++ F KE LG S+QK WA++V +SF+++APTGVGK+ FGL M+ YLA Sbjct 55 ELLSELKDWEDFFKEILGTSPWSLQKSWARKVFLGRSFAMLAPTGVGKTTFGLSMASYLA 114 Query 119 DRGKRCYIILPTTLLVKQTYERAQSLVGDNIKVVCYHSELSEREKRDIKKRIEEGDFQVL 178 +GK+ YIILPT LLV+Q ER ++ D +++ + +LSE++K+++K+RI++GDF +L Sbjct 115 KQGKKSYIILPTQLLVEQVSERIKTFGVDEDRLIVW-GKLSEKKKKELKERIQKGDFDIL 173 Query 179 ITTSNYLTRN--MPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKIILLM 236 ITTS +L +N + P F FIFVDDVD+ LK++KN+D+ L LLGFS E I +A+++I L Sbjct 174 ITTSMFLYKNYEILPKDFSFIFVDDVDSFLKTAKNVDKVLYLLGFSEEDIHKAFELIRLK 233 Query 237 KWRKFDKALELREKLRKKLEGI------KHGCIVIASATGKSYGDKVKLYRELLNFEVGY 290 + K +K+ E E+++K+ E + K G + ++SATG +++KL+RELL FEVG Sbjct 234 E--KPNKSEEDWEEIKKRSEELREIAKKKKGVLAVSSATGNPRSNRIKLFRELLGFEVGK 291 Query 291 GINKLRDVVDVYDEID--RDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLLRENNIKA 348 LR++V+ Y+E ++ +L+ VK G GGL+FVS DYG E ++++ L + +KA Sbjct 292 PSVLLRNIVETYEETQNLKETLLKRVKEFGKGGLVFVSSDYGREAVEEVKKFLESHGVKA 351 Query 349 KVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKFKLR-- 406 V + +D + FE G+ V IG++S+ L RG+D+P VRYAIFYG+PK++ L+ Sbjct 352 -VTYEEDLKLFE---KGEAQVAIGISSFKNPLARGIDLPHVVRYAIFYGVPKIRVPLKVE 407 Query 407 -------------------------------EYLEKVRKNRKIDID-----------IEG 424 +++++R+ + D IE Sbjct 408 TSVSHLLWALLSLRPIILKDEKLKSEVKKVDTWIQRLRRYSFLSDDFVEERPDLKDRIEN 467 Query 425 KSLEEIEDILKRDL--KLRN---FSIKVEDDEIYILIPDIKTYIQASGRTSRMTEFGLTK 479 E E +L+ D+ K++N ++++ ++ +++ D+ Y+QASGRTSRM GLTK Sbjct 468 LRKEVQEFLLREDIVEKIKNSEELTLRLGEEGFELVVADVTGYLQASGRTSRMYAGGLTK 527 Query 480 GVSILLVDHWKLFESIEKYM-LFHYESEFKSAREVNFEELIKKIDEDREKIKLCMRRGKV 538 G+S +LVD + F+++EK + F+ + FK EV+ +E++++IDEDR+K++ + GKV Sbjct 528 GLSHVLVDDRRAFKNLEKKVRWFNQDINFKKIEEVDLKEVLREIDEDRKKVREILE-GKV 586 Query 539 P----DILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHI 594 + +K +L+VVESPNKARTIA+FFG+P RKI GI+V EV +GD+ ++ITAS GH+ Sbjct 587 KAEQKEHVKPVLVVVESPNKARTIANFFGKPMGRKIGGIDVLEVMVGDLYIMITASLGHV 646 Query 595 FDLVTKEGYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCR 654 FDLV + ++GV ++ Y+PIY E+IE E++ Sbjct 647 FDLVKDKEFHGVIAKNGEYVPIY----------------------EVIEGKENI------ 678 Query 655 DNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRA 714 ++ +RE+A EVD V I TD DTEGEKIG+D+G + P+ N+ RI F+E+TR+AI A Sbjct 679 --VKGLRELAQEVDTVLIGTDPDTEGEKIGWDLGALLSPYIPNVERIEFHEVTRKAIKHA 736 Query 715 VEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWI 774 VE R +EN VK+QLVRRI DRW+GF++S + + F K++LS GRVQ PVLGWI Sbjct 737 VENPR-----DFNENLVKAQLVRRIADRWVGFEVSRIVQQAFDKHWLSGGRVQIPVLGWI 791 Query 775 IERYEEHKKKVPYLSLKL-EYDIYVGKIWEGDFKGEEVEVEVNLYSRDI----------S 823 IER + ++KK + + E ++ +E K E E NL D+ + Sbjct 792 IEREKLYRKKKHVVQITFKENGRWLRLGFEFQDKKEAKEFYENLKEIDVEVLEEREELKN 851 Query 824 PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGMKVAREYL 883 P PPFTTDT+L+EA+ R+ +S ++M++AQ+LFE GL TYHRT STRVS G+ VA+E++ Sbjct 852 PPPPFTTDTMLKEASDRYRISVPKLMQLAQELFEYGLITYHRTDSTRVSDVGIGVAKEWI 911 Query 884 KLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRENNI-SLSKNHIKLYDLIFRR 942 ++ R + G HECIRPTKP+D +L + + +L++ H+ LY+LIF+R Sbjct 912 SEELGKELFYPRVWGEGGAHECIRPTKPLDVEDLRSMMLAGQLQNLTREHLLLYELIFKR 971 Query 943 FIASQMKEATVVYEELYIKDIDERIEGYVDVEF--DGWTRIYNLKLRKLPKIEKSKLKVL 1000 F+ASQMK V +++ +K + E + E +G+ ++Y L+L+ P ++ S Sbjct 972 FMASQMKPVKVKTKKVKVKALGREQELILTTEILEEGFNKVYPLELQ--PDLKGSVYVED 1029 Query 1001 DYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKL 1060 ++ V LY +G +V+ MK RGIGRPSTYA I+ KLL+RGYVI + G LIPTKL Sbjct 1030 KKELKSVPMAYLYTQGSLVEEMKRRGIGRPSTYATIVSKLLERGYVI--ERHGFLIPTKL 1087 Query 1061 GIEVYNYLITHYP--HLISEEKTRELEEIMDKIERGEVDYIQVLHAL 1105 G +VY +L + +SEE TR+LEE+MDK+E G+ DY+QVL L Sbjct 1088 GKQVYEFLKSREKIMPFVSEEFTRKLEELMDKVEEGKEDYLQVLDEL 1134 >RecName: Full=Reverse gyrase 2; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Aquifex aeolicus VF5] Sequence ID: O67226.2 Length: 1159 Range 1: 10 to 1147 Score:712 bits(1838), Expect:0.0, Method:Compositional matrix adjust., Identities:466/1181(39%), Positives:689/1181(58%), Gaps:125/1181(10%) Query 10 CPNCFGEIYSSRLELGV-CERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCKVWNEFKKF 68 CPNC G I S RLE G+ C +CL + ++ +C L + K L LK +C ++F Sbjct 10 CPNCGGVISSDRLEKGLPCSKCLP---KPTEEKVCDALEELKTLKYLKPFCDTDKSLERF 66 Query 69 -DRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLADRGKRCYII 127 + F K +G + S+Q++WAKRV N+SF+IVAPTGVGK+ FGL+MSL+L R I Sbjct 67 INFFEKAVGAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFLKGR---VLAI 123 Query 128 LPTTLLVKQTYERAQSL---VGDNIKVVCYHSELSEREKRDIKKRIEEGDFQVLITTSNY 184 PT LL +Q +R L VG N K++ Y S K++I+++ GD+ +L+ T+ + Sbjct 124 FPTRLLAQQAGDRLSELAQKVGVNKKILIYQS------KKNIREQFLNGDWDILLGTNMF 177 Query 185 LTRNMPPTT---FDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKIILLMKWRKF 241 L +N F IF+DD+D+ LK KN+D LLGFS E I A K R + Sbjct 178 LHKNFENLINFKFKLIFIDDIDSFLKRGKNVDYLFKLLGFSGEEIKLALKEN--KTQRDY 235 Query 242 DKALELREKLRKKLEGIKHGCIVIASATGKSYGDKVKLYRELLNFEVGYGINKLRDVVDV 301 D+ +R++ R + ++++SAT K G + L+R LL F+V I LR++VDV Sbjct 236 DRLARIRKRKRDTV-------LIVSSATLKPRGKRAYLFRNLLGFDVQKAITTLRNIVDV 288 Query 302 YDEIDR-----DKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLLRENNIKA-KVVHSKD 355 + + +K +E +K LG GGL+++S YG + ++++ R++ I A + K Sbjct 289 AEPVKDLEEALEKSVELIKKLGKGGLVYLSVFYGKDKVQEVKEFYRKHGINAVSYLDYKP 348 Query 356 KEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKF------------ 403 +E ++ G+ DV +G++ LVRG+D+P +RYA+F PK F Sbjct 349 EELYQILEKGEFDVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPTELTLSPPLLH 408 Query 404 --------------KLRE-----YLEKVRKNRKIDIDIEGK---SLEEIEDILKRDLKLR 441 +L+ YL++ R+ +D + +EEI++ L+ LK Sbjct 409 GLLLTLLNLFEGDDRLKAIQYVMYLKRYLTLREEQLDNYPRIKERVEEIKNFLENYLKDE 468 Query 442 NFSIKVEDDE----------IYILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKL 491 NF K+++ E +YI++ D +YIQASGRTSR G+TKG+S++ K Sbjct 469 NFLKKIKESEDISLVPKEGKLYIVVGDANSYIQASGRTSRFIAGGMTKGLSVVYYSDPKA 528 Query 492 FESIEKYMLFHY---ESEFKSAREVNFEELIKKIDEDREKIKLCMRR---GKVPDILKSI 545 F S++K + +Y E EFK EV+ +LIK+IDEDR++ + ++ ++ D+ K+ Sbjct 529 FYSLKKRLALYYMTQEIEFKRLSEVDLNKLIKEIDEDRKRAREILQGKGVAQIKDLFKTT 588 Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESPNKARTIA FFG+P R + YEV +GD L+ITAS GH+ DLVT +G++G Sbjct 589 LVIVESPNKARTIAGFFGKPQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFFG 648 Query 606 VKIEDNIYIPIYMAIR--KINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREI 663 V + Y+P+Y I+ + EQ T+ E ++K K+ + + ++ +RE+ Sbjct 649 VLDDTYPYLPVYDTIKICRETHEQHTEY--------EYLKKRCKGKIEDKLEIIKGVREV 700 Query 664 ADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEE 723 + EVD VFIATD D EGEKIGYD+ L PFN NI R F+E+T +A A++ R Sbjct 701 SYEVDEVFIATDPDAEGEKIGYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPR---- 756 Query 724 LKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKK 783 ++D N VK+QLVRRI DRW+GF LS LW+ F K +LSAGRVQTPVLGW+I+RYEE K+ Sbjct 757 -EVDLNLVKAQLVRRILDRWVGFTLSHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKE 815 Query 784 K-------VPYLSLKLEY-DIYVGKIWEGDFKGEEVEVEVNLYSRDISPSPPFTTDTLLE 835 K V LK+E D+ K D + ++ + N + P PP+TTDT+LE Sbjct 816 KKGEILLHVNDFPLKIEIEDLMFAKEIFKDLELADISLS-NPQEEEKRPLPPYTTDTVLE 874 Query 836 EATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEG-MKVAREYLKLSNLEDYLKN 894 +A ++ +LS + M+I Q+LFE G TYHRT STRVS G VA+ Y+ E+Y Sbjct 875 DANEKLHLSAHKTMKILQELFEAGYITYHRTDSTRVSDAGKYLVAKPYITKMFGEEYFYP 934 Query 895 REFYMEGPHECIRPTKPMDTGELIEFIRENNISL---SKNHIKLYDLIFRRFIASQMKEA 951 R + G HECIRPT+P++ +L EF+ I+ +N +K+Y+LIF+RF+ASQM+ A Sbjct 935 RSWGEGGAHECIRPTRPLEPKDL-EFMITAGIAEFEDPENALKVYELIFKRFMASQMRPA 993 Query 952 TVVYEELYIK----DIDERIEGYVDVEFDGWTRIYNLKLRKLPKIEKSKLKVLDYSIRKV 1007 V+ EE+ +K + ER+ +V+ G+ +Y + PK K KL++ R+V Sbjct 994 KVITEEIILKLPYFEWKERV--VTEVKEHGFDLMYP-TFKVFPK--KEKLEITHKEFREV 1048 Query 1008 NKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNY 1067 KV Y +G +++ MK RG+GRPSTYAQI++ LL+R YV+ + KG LIPT LG EVY Y Sbjct 1049 PKVYPYTQGTLIQEMKRRGLGRPSTYAQIVQTLLERHYVV--EEKGFLIPTDLGREVYEY 1106 Query 1068 LITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHALKSI 1108 L H+P SEE TR+LEE MDKIERGE+DY++VL + I Sbjct 1107 LTKHFPEWTSEELTRKLEEAMDKIERGELDYMEVLKEVHRI 1147 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Pyrobaculum aerophilum str. IM2] Sequence ID: Q8ZXT5.1 Length: 1228 Range 1: 3 to 1214 Score:699 bits(1805), Expect:0.0, Method:Compositional matrix adjust., Identities:461/1239(37%), Positives:688/1239(55%), Gaps:162/1239(13%) Query 2 IPII-YKEMCPNCFGEIYSSRLELGV-CERCLEEEERCSKL-DLCRKLGDKKKLDKL--- 55 +P++ Y CPNC G I S RL G+ C CL + + + + L +K L L Sbjct 3 VPLVAYLHSCPNCGGPITSDRLASGLPCRECLPDGAKAGSIKQVITALRKRKALQGLAWV 62 Query 56 KGYCKVWNEFKKFDRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSL 115 + Y + + EF +F F + +G+E+ Q++WA+R ++ KSF+IVAPTG GK+ F L+ +L Sbjct 63 EAYLRGYEEFAEF--FKRIVGFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATL 120 Query 116 YLADRGKRCYIILPTTLLVKQTYERAQSLV---GDNIKVVCYHSELSEREKRDIKKRIEE 172 Y A +GKR +I PT+ L Q Y++ + G ++K + YHS L+EREK++ + +E Sbjct 121 YSAKQGKRALLIFPTSALAHQAYKKLLTFAERGGVSLKALAYHSLLTEREKKEALEALER 180 Query 173 GDFQVLITTSNYLTRNMPPTT---FDFIFVDDVDALLKS-SKNIDRTLLLLGFSRELIDE 228 GDF VL+TTS +L + + FDF+ DDVD++L++ SKNIDR L LLG S +++ Sbjct 181 GDFDVLVTTSAFLPKRFELLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDAVLNT 240 Query 229 AYKIILLMK-WRKFDKA-------------LELREKLRKKLEGIKHGCIVIASATGKSYG 274 A ++I L K RK + A +LR KLR++++ +K G V + A K+ Sbjct 241 ALEVINLTKQLRKAEVAGDLKEVERLDQEMAKLRAKLREEVQRLKLGVFVASGALAKARR 300 Query 275 D-KVKLYRELLNFEVGYGINKLRDVVDVYDEIDRD---KVLEYVKLLGPGGLIFVSQDYG 330 ++ L+RE+L F+VG LR+VVD+Y E + + L VK LGPGG+I+V QD Sbjct 301 TVRLLLFREILGFDVGGRAEGLRNVVDLYVEASDNVIEQTLALVKRLGPGGIIYV-QDR- 358 Query 331 LEVAKDIENLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERV 390 E+ + I RE + + + E F G++ L+G+AS LVRG+D+P + Sbjct 359 -ELGEAIVERAREAGLAVEHFFRPRRGVLESFERGELAALVGLASSRSALVRGIDLPHVI 417 Query 391 RYAIFYGIPKMKFK---------------------------------------------- 404 RY IF G+PK KF+ Sbjct 418 RYVIFVGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLAGDARYKADRLIGQLKRLAPYALS 477 Query 405 LREYLEKVRKNRKID------IDIEGKSLEEIEDILKRDLKLRNFSIKVE------DDEI 452 ++E L+K + ++ +D+ ++E + +L+ + + E D E+ Sbjct 478 VQEALKKASEGAELSSFDRHAVDVVKSAVEFVNSLLQNEEIRKAIETSSEVKLAYIDGEM 537 Query 453 YILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHY-ESEFKSAR 511 Y+L+PD+ TYIQ SGRTSR+ GL+KG+S+++VD K+F ++++ + + E+EFK Sbjct 538 YVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDPKVFHALKRELSLRFDEAEFKHLG 597 Query 512 EVNFEELIKKIDEDREKIKLCMRRGKVP-----DILKSILMVVESPNKARTIASFFGRPS 566 E + ++++ +D DR+ I+ M VP D++++ILMVVESP KARTIA+FFGRPS Sbjct 598 EADLDKILADVDRDRKTIRDIMEGRLVPAARGVDLMRTILMVVESPTKARTIANFFGRPS 657 Query 567 RRKIRGINVYEVCIGDINLIITASGGHIFDLVT--------------------KEGYY-- 604 GI +YEV GD L++TAS GHI++L T K G Y Sbjct 658 LIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSLNKIDQRQREVLAKWFGDFKHGNYDG 717 Query 605 ---GVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIR 661 V +++ ++P+Y I + G D DI + L D +E IR Sbjct 718 ENYAVIVKEYGFVPVYNKIWRCRGAVYVDDIDIPPGCKPL-------------DVLEAIR 764 Query 662 EIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRG 721 IA EVD V + TD D+EGEKI +D+ L + P+ ++I R+ F+E+TRRAIL A+ A RG Sbjct 765 NIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRRAILNAL-ANPRG 823 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEH 781 L VK+Q+VRR+EDRWIGF LS+ L FK LSAGRVQTPVLGWI+ YEE Sbjct 824 VNFSL----VKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWIVNTYEES 879 Query 782 -KKKVPYLSLKL-EYDIYVGKIWEG-DFKGEEVEVEVNLYSRD---ISPSPPFTTDTLLE 835 K +V + L+L + DI + + D ++ V + L +R+ ++P PP+TTD LL Sbjct 880 LKNRVYNVELQLNDVDIRLQVPRDVLDVLRKKKRVAIKLVARERRQVNPPPPYTTDELLR 939 Query 836 EATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNR 895 +A + LS + MR+AQDLFE GL TYHRT STRVS G+ +AREY+ E K R Sbjct 940 DAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGIAIAREYIVRKFGEGVFKPR 999 Query 896 EF--YMEGPHECIRPTKPMDTGELIEFIREN----NISLSKNHIKLYDLIFRRFIASQMK 949 + EG HE IRPT+P+D EL + I L+K+H +LYD+IFRRF+ASQM Sbjct 1000 SWGEAEEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQLTKSHYQLYDIIFRRFMASQM- 1058 Query 950 EATVVYEELYIKDIDERI---EGYVDVEFDGWTRIYNLKLRKLPKIEKSKLKVLDYSIRK 1006 E +VV Y +ID + E V V + G+ +Y L + P++ L V+ R Sbjct 1059 EPSVVEVAKYNVEIDGHVIQLERTVGVAYMGFQTLYQLTPVE-PELPTGTLDVVIKRYRV 1117 Query 1007 VNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYN 1066 V +V + +V+ LM++RGIGRPSTYA I++ L R YV + +IPTK G E++ Sbjct 1118 VRRV--LSQADVLALMRQRGIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFR 1175 Query 1067 YLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHAL 1105 +L + L+SE++TR +E+ MD IE G+ Y +V+ L Sbjct 1176 FLKEAFGKLVSEDRTRLIEQYMDAIEVGKARYEEVIAEL 1214 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Archaeoglobus fulgidus DSM 4304] Sequence ID: O29238.1 Length: 1054 Range 1: 1 to 1046 Score:698 bits(1801), Expect:0.0, Method:Compositional matrix adjust., Identities:451/1155(39%), Positives:660/1155(57%), Gaps:159/1155(13%) Query 1 MIPIIYKEMCPNCFGEIYSSRLELGVCERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCK 60 MIP++Y +CP C G++ S +E VC R K + C Sbjct 1 MIPVVYSNLCPVCGGDLESKEIEKHVCFR------------------------KKRSLCL 36 Query 61 VWNEF--KKFDRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLA 118 +F K+F F ++ E +IQKMWAKR+L+ +SF+ APTGVGK+ FGL MSL+LA Sbjct 37 FPEDFLLKEFVEFFRKCVGEPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFLA 96 Query 119 DRGKRCYIILPTTLLVKQTYER-----AQSLVGDNIKVVCYHSELSEREKRDIKKRIEEG 173 +GKRCY+I PT+LLV Q E ++ VG + YH + +REK + + + Sbjct 97 LKGKRCYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLR-- 154 Query 174 DFQVLITTSNYLTRNMPP-TTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKI 232 +F+++ITT+ +L+++ FDFIFVDDVDA+LK+SKN+D+ L LLGF +L +++ Sbjct 155 NFKIVITTTQFLSKHYRELGHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTKSWV- 213 Query 233 ILLMKWRKFDKALELREKLRKKLEGIKHGCIVIASATGKSYGDKVKLYRELLNFEVGYGI 292 G GC+++++AT K G K +L+R+LLNF++G Sbjct 214 ------------------------GEARGCLMVSTATAKK-GKKAELFRQLLNFDIGSSR 248 Query 293 NKLRDVVDVYDEIDRDKVLEYV-KLLGPGGLIFVSQDYGLEVAKDIENLLRENNIKAKVV 351 +R+V DV + L + + LG GG+I+ G E + E+L +N + +V Sbjct 249 ITVRNVEDVAVNDESISTLSSILEKLGTGGIIYART--GEEAEEIYESL--KNKFRIGIV 304 Query 352 HSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKF-------- 403 + K +E F G+ID LIG A YYG LVRGLD+PER+R+A+F G P + Sbjct 305 TATKKGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAVFVGCPSFRVTIEDIDSL 364 Query 404 -----KLREYL-EKVRKNRKIDIDIEGKSLEEIEDILKRDL-KLRNFSIKVEDDEIYILI 456 KL YL V + ++ +E + ++E+ +ILK+ + K R + V E ++ Sbjct 365 SPQMVKLLAYLYRNVDEIERLLPAVE-RHIDEVREILKKVMGKERPQAKDVVVREGEVIF 423 Query 457 PDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFES-IEKYMLFHYESEFKSAREVNF 515 PD++TYIQ SGRTSR+ GLTKG S LL D +L + IE+ L Y+ EFKS EV+F Sbjct 424 PDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIERAKL--YDIEFKSIDEVDF 481 Query 516 EELIKKIDEDREKIKLCMRRGKVPDILKSILMVVESPNKARTIASFFGRPSRRKIRGINV 575 E+L +++DE R++ RR + D++K L +VESP KAR I+ FFG+PS + + G V Sbjct 482 EKLSRELDESRDR----YRRRQEFDLIKPALFIVESPTKARQISRFFGKPSVKVLDGAVV 537 Query 576 YEVCIGDINLIITASGGHIFDLVTKEGYYGVKIEDNIYIPIYMAIRKIN--GEQITDQKD 633 YE+ + L++TAS GH+ DL+T G++GV + + ++P+Y +I++ G Q T+ Sbjct 538 YEIPMQKYVLMVTASIGHVVDLITNRGFHGVLV-NGRFVPVYASIKRCRDCGYQFTED-- 594 Query 634 IEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILP 693 RE K S V N R +E +R++A + + V + TD DTEGEKI +D+ N+L Sbjct 595 -----RESCPKCGSENVDNSRSRIEALRKLAHDAEFVIVGTDPDTEGEKIAWDLK-NLLS 648 Query 694 FNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLW 753 + R F+E+TRRAIL A+E+ R +DEN VK+Q+VRRIEDRWIGF LS+KLW Sbjct 649 GCGAVKRAEFHEVTRRAILEALESLR-----DVDENLVKAQVVRRIEDRWIGFVLSQKLW 703 Query 754 EVFKKNYLSAGRVQTPVLGWIIERYEEHKKK-----VPYLSLKLEYDIYVGKIWEGDFKG 808 E F LSAGR QTPVLGWII+R++E +++ V L LE+D Sbjct 704 ERFNNRNLSAGRAQTPVLGWIIDRFQESRERRKIAIVRDFDLVLEHD------------E 751 Query 809 EEVEVEVNLYSRD---ISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHR 865 EE ++ + L +P PP+TT+T+L +A + S ++ M+IAQ+LFE GL TYHR Sbjct 752 EEFDLTIKLVEEREELRTPLPPYTTETMLSDANRILKFSVKQTMQIAQELFENGLITYHR 811 Query 866 TSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRENN 925 T STRVS G ++A+EYL D RE+ G HECIRPT+P+ ++ I+E Sbjct 812 TDSTRVSDVGQRIAKEYLG-----DDFVGREWGESGAHECIRPTRPLTRDDVQRLIQEGV 866 Query 926 I---SLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDVEFDGWT--- 979 + L H LYDLIFRRF+ASQ + VV ++ I EFDG T Sbjct 867 LVVEGLRWEHFALYDLIFRRFMASQCRPFKVVVKKYSI-------------EFDGKTAEE 913 Query 980 --------RIYNLKLRKLPKIE-KSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRP 1030 R Y L K E + + ++ V KV + + E++++MKERGIGRP Sbjct 914 ERIVRAEGRAYELYRAVWVKNELPTGTFRVKAEVKSVPKVLPFTQSEIIQMMKERGIGRP 973 Query 1031 STYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDK 1090 STYA I+ +L R YV+ + G++IPTKLGI+V+ +L+ Y +SE++TR+LE MD Sbjct 974 STYATIVDRLFMRNYVV--EKYGRMIPTKLGIDVFRFLVRRYAKFVSEDRTRDLESRMDA 1031 Query 1091 IERGEVDYIQVLHAL 1105 IERGE+DY++ L L Sbjct 1032 IERGELDYLKALEDL 1046 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Thermotoga maritima MSB8] Sequence ID: O51934.1 Length: 1104 Range 1: 7 to 1093 Score:679 bits(1751), Expect:0.0, Method:Compositional matrix adjust., Identities:440/1128(39%), Positives:674/1128(59%), Gaps:69/1128(6%) Query 6 YKEMCPNCFGEIYSSRLELGV-CERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCKVWNE 64 Y C NC G R E G+ CE CL E+ S D+ R L ++K L + + Y + WNE Sbjct 7 YHHSCINCGGLNTDERNERGLPCEVCLPED---SPSDIYRALLERKTLKEYRFYHEFWNE 63 Query 65 FKKFDRFCKE-LGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLADRGKR 123 ++ F F K+ G +L Q++WAKR+++ KSF++VAPTGVGK+ FG++ +L+LA +GK+ Sbjct 64 YEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKK 123 Query 124 CYIILPTTLLVKQTYERAQSLVGDNIKVVCYHSELSEREKRDIKKRIEEGDFQVLITTSN 183 ++ PT LVKQT ER Q L + +K+ ++S + + EK +K EE D+ +L+ ++ Sbjct 124 SALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQ 183 Query 184 YLTRN---MPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKIILLMKWRK 240 ++++N + FDF+FVDDVDA+LK+S+NID L+++G E+I +A+ I Sbjct 184 FVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTI------- 236 Query 241 FDKALELREKLRKKLEGIKHGCIVIASATGKSYGDKVKLYRELLNFEVGYGINKLRDVVD 300 + K+ ++ + +K G +V++SAT K G + L+R+LLNF VG ++ R++ Sbjct 237 ------KQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITH 290 Query 301 V-YDEIDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLLRENNIKAKVVHSKDKEGF 359 V ++K++E +++ G LIF + E K++ L+ S+ ++ F Sbjct 291 VRISSRSKEKLVELLEIFRDGILIFAQTE---EEGKELYEYLKRFKFNVGETWSEFEKNF 347 Query 360 EDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKFKL------REYLEKVR 413 EDF+ GKI++LIGV +YYG L RG+D+PER++Y IF+G P M+F L R L +V Sbjct 348 EDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVL 407 Query 414 KNRKIDIDIEGKSLEEIEDILKRDLKLRNF---------SIKVEDDEIYILIPDIKTYIQ 464 K + E +EE+ I K L + F + V+D+++ ++IPD+ TYIQ Sbjct 408 KEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQ 467 Query 465 ASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHYESEFKSAREVNFEELIKKIDE 524 ASGR+SR+ L KGVS++ + ++FES++ +L E E E N++EL+ +++E Sbjct 468 ASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEE 527 Query 525 DREKIKLCMRRGKVPDILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDIN 584 R + + + D +S+L++VESP KA T++ F GR S RK R I V+E G+ Sbjct 528 SRRRSEREL-----TDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGV 582 Query 585 LIITASGGHIFDLVTKEGYYGVKIEDNIYIPIYMAIRKIN--GEQITDQKDIEEILRELI 642 ++ TA+ GH++DLVTK G +GV+ E+ ++P+Y ++++ G Q T+ +D + Sbjct 583 ILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVC---- 638 Query 643 EKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIG 702 S + + + + +REI+ E D + +ATD D EGEKI +D+ +LP R++ RI Sbjct 639 ---SSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIE 695 Query 703 FNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLS 762 +EITR +A E+ R +D N VK+Q+VRR++DRWIGF+LS KL + F ++ LS Sbjct 696 MHEITRYGFKKARESVRF-----VDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLS 750 Query 763 AGRVQTPVLGWIIERYEEHKKKVPYLSLKLEYDIYVGKIWEGDFKGEEVE-VEVNLYSRD 821 AGRVQ+ VLGWI+ER EE+KK +L L + V EG + V VE+ + Sbjct 751 AGRVQSTVLGWIVEREEEYKKSEKDFTL-LVLENGVNLEVEGKIADDVVTVVELQEAEEE 809 Query 822 ISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGMKVARE 881 +P PP+TT + L E +++ L +EVM I QDLFE G TYHRT STR+SLEG VAR Sbjct 810 KNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVART 869 Query 882 YLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRENNIS-LSKNHIKLYDLIF 940 YL+ ED R + EG HE IRP KP+D EL E I E I+ L+K H+++Y+LIF Sbjct 870 YLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIF 929 Query 941 RRFIASQMKEATVVYEELYIKDIDER---IEGYVDVEFDGWTRIYNLKLRKLPKIEKSKL 997 RF+ASQ A V +++ D+D + IE V++ DGW L + P+ E Sbjct 930 NRFLASQ-SAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVS--PRFEHRTY 986 Query 998 KVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIP 1057 K+ + K + VPL+ + +V+ MK+RGIGRPSTYA+I++ L RGYV + K K ++ P Sbjct 987 KIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYK-RVRP 1045 Query 1058 TKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHAL 1105 T+ G+ VY+YL Y ++EE TR LEEIMDK+ERGE DY L L Sbjct 1046 TRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLL 1093 >RecName: Full=Reverse gyrase 1; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Saccharolobus solfataricus P2] Sequence ID: Q97ZZ8.1 Length: 1242 Range 1: 9 to 1234 Score:668 bits(1723), Expect:0.0, Method:Compositional matrix adjust., Identities:478/1255(38%), Positives:684/1255(54%), Gaps:181/1255(14%) Query 3 PIIYKEMCPNCFGEIYSSRLELG-VCERCLEEEERCSKL-DLCRKLGDKKKLDKLKGYCK 60 P IY CPNC G I S RL G VCE CL+++ S L DL L + L L Sbjct 9 PSIYTRSCPNCGGNISSQRLFNGSVCESCLKDDREFSNLSDLINILSENSNLKNLTQIRD 68 Query 61 VWNEFKKFDRFCKEL--GYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLA 118 V E+KK + +L + + Q+ W R L+ +SF+I+AP G+GK+ FGL+MSLY A Sbjct 69 VLEEYKKVEEIFGKLLNNSKPIGPQRSWTIRFLRGESFAIIAPPGLGKTTFGLIMSLYNA 128 Query 119 DRGKRCYIILPTTLLVKQTYERAQ--SLVGDNIKVVCYHSELSEREKRDIKKRIEEGDFQ 176 R ++ II PT L+ QT ++ S + + Y+ + S + +I +++ G+F Sbjct 129 TRNRKSIIIFPTRTLISQTVDKLAKFSELYSYSPRILYNKQ-SPTQTENILDQLKSGNFD 187 Query 177 VLITTSNYLTRNMPPTT---FDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKII 233 + I+T+ ++ +N+ + FDFIFVDDVDA LKS K+ L L+GF+ E I K++ Sbjct 188 IFISTNRFVIQNLSELSNIKFDFIFVDDVDAALKSGKSAKAILRLVGFTDEDIQTTMKLL 247 Query 234 L--LMKWRKFDKALELRE-KLRKKLEGIKHGCIVIASATGKSYGDKVKLYRELLNFEVGY 290 + + KF K E+RE +L+ K IVI S+ S G+ + L+ F G Sbjct 248 RENIGEEEKFGKIQEIRESRLKDK--------IVIFSSATISRGNPI--LSSLMGFRPGS 297 Query 291 GINKLRDVVDVY------------DEIDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIE 338 + LR++ D Y +E V++ +K L G LIFV D G + A + Sbjct 298 SVIYLRNIYDSYIDLTQTCKGQDFEECTLGTVIKLLKRLNDGTLIFVPIDKGAQYADYLA 357 Query 339 NLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGI 398 + LR++ I + V S E F G++ L+GVA++YGVLVRG+D+P RV+Y+IF GI Sbjct 358 SNLRDHGINVESVASSSISKLEKFERGEVSSLVGVATHYGVLVRGIDLPWRVKYSIFVGI 417 Query 399 PKMKFKLREYL------------------EKVR--------KNRKI----------DI-- 420 PK KFK+ EY+ +KVR + RKI DI Sbjct 418 PKFKFKIGEYMHPLALTRLLSLVYLVKNDDKVRGLLSYIRKRLRKISPAALAMLAKDIRE 477 Query 421 -DIEGKSLEEIEDILKRDLKLRNFSIKVED------DEIYILIPDIKTYIQASGRTSRMT 473 I+ + L+E +++ LK F KV D + YIL+PD TYIQASGRTSR+ Sbjct 478 GKIDDERLKEAYNLVNEYLKDNEFLKKVSDVGDLVIEGDYILMPDYLTYIQASGRTSRLY 537 Query 474 EFGLTKGVSILLVDHWKLFESI--------EKYMLFHYESEFKSAREVNFEELIKKIDED 525 LT G+S+LL+D+ +LFE + ++ + + + +V+ ++ KI E+ Sbjct 538 GANLTTGLSVLLIDNSRLFELLNKKLNLILDEVKWYSLDIDADKLGQVSLSDISAKITEE 597 Query 526 REKIKLCMRRGKVPDI---LKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGD 582 RE + + G V +K+ L +VESPNKA+TI++FF RPS R + VYE +GD Sbjct 598 RESLSKIKKEGNVESSSLSVKTTLFIVESPNKAKTISNFFSRPSTRSYGKLRVYETVLGD 657 Query 583 INLIITASGGHIFDLVTKEG--------YYGVKIEDNIYIPIYMAIRKI-NGEQITDQKD 633 LI+ ASGGHI+DL+T++ YGV ++D+ +IPIY I+K G QI Sbjct 658 RVLIVAASGGHIYDLITEDESEKQDDNYVYGVLVKDSKFIPIYSTIKKCEKGHQI----- 712 Query 634 IEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILP 693 ++++ + S V + + ++ +R++A EVD V I TD DTEGEKI +DI L I P Sbjct 713 VKDLSQNKCPICGSRIVTDKTEVVDILRKLALEVDEVLIGTDPDTEGEKIAWDIYLAIRP 772 Query 694 FNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKL- 752 FN NI R F+E+TRRAIL A++ R + ++N VKSQ+VRRIEDRWIGFKLS KL Sbjct 773 FNGNIKRAEFHEVTRRAILNAIKNPR-----EFNDNLVKSQIVRRIEDRWIGFKLSRKLQ 827 Query 753 ---WE-----VFKKNY----------LSAGRVQTPVLGWIIERYE---EHKKK------- 784 WE + KKN LSAGRVQTPVL W++ RY+ E+KKK Sbjct 828 TEFWEQHCTSISKKNSKDEECKENRNLSAGRVQTPVLDWVVNRYQKYNENKKKYLIIESQ 887 Query 785 ----VPYLSLKLEYDIYVGKIWEGDFKGEEVEV---EVNLYSRDISPSPPFTTDTLLEEA 837 P+ L L+ + G K ++ + ++N+ + P PP+TTDTLL +A Sbjct 888 DKSIFPFSVLALKKN--------GLSKNTQIIIHLEDINIKEEEFGPLPPYTTDTLLSDA 939 Query 838 TKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGMKVAREYLKLS--NLEDYLKNR 895 + + MR+AQDLFELGL TYHRT STRVS G+ VA YLK ++ + R Sbjct 940 ANLLRIPASDTMRVAQDLFELGLITYHRTDSTRVSNVGISVAETYLKSKQVDISKIFRPR 999 Query 896 EFYMEGPHECIRPTKPMDTGELIEFIRENNISLSK----NHIKLYDLIFRRFIASQMKEA 951 + G HE IRPTKP+D L I + ++ LSK NH ++Y+LIFRRFI SQ+ Sbjct 1000 SWGEGGAHEAIRPTKPLDETMLKASIEQGDLELSKQLTFNHFRVYNLIFRRFITSQLPPL 1059 Query 952 TVVYE----ELYIKD-----IDER----IEGYVDVEFDGWTR-----IYNLKLRKLPKIE 993 V + Y KD +DE + GY E D + + IY L P E Sbjct 1060 VVTKQIVRIRAYTKDNIELELDENKKEFVIGYKLKEGDEFRQTLQDAIYTLFRLYQPLDE 1119 Query 994 KSKLKVLDYSIR-KVNK--VPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSK 1050 K K K L +I +NK V LY EGE++ MK + IGRPSTYA II L R Y+I+SK Sbjct 1120 KMKGKELSATITGTLNKSDVQLYTEGELISEMKSKQIGRPSTYAVIISTLKKRRYIIESK 1179 Query 1051 NKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHAL 1105 N K+IPTKLG+ V YL+ +Y ++SE++T +L E M+++E G+VDY+ +L L Sbjct 1180 NLKKIIPTKLGMAVKEYLMENYKQIVSEKRTVKLLEKMNEVEEGKVDYLVLLKEL 1234 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase; Contains: RecName: Full=Pko r-Gyr intein [Thermococcus kodakarensis KOD1] Sequence ID: Q6F598.1 Length: 1711 Range 1: 4 to 970 Score:663 bits(1710), Expect:0.0, Method:Compositional matrix adjust., Identities:407/984(41%), Positives:590/984(59%), Gaps:132/984(13%) Query 5 IYKEMCPNCFGEIYSSRLEL-GVCERCLEEEERC-SKLDLCRKLGDKKKLDKLKGYCKVW 62 +Y+EMCPNC+G I RL + CE CL+E S L + + KL+G K W Sbjct 4 VYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAV---RNALKLRGTLKEW 60 Query 63 -------NEFKKFDRFCKEL-GYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMS 114 N+ ++ + F K+ G+ S Q+ W KR+LK +SFSI+APTG+GKS FG M+ Sbjct 61 EKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 Query 115 LYLADRGKRCYIILPTTLLVKQTYERAQSLVGD---NIKVVCYHSELSEREKRDIKKRIE 171 ++ A +GK+ YI++PTT LV QT + + ++ + ++++ YH L ++EK ++ +RI+ Sbjct 121 VWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIK 180 Query 172 EGDFQVLITTSNYLTRN----MPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELID 227 D+ +L+T++ +L RN + FDFIFVDDVDA LK+SKNIDR+L LLGF+ E+I Sbjct 181 NEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQ 240 Query 228 EAYKIILLMKW--RKFDKALELR-----------EKLRKKLEGIKH----GCIVIASATG 270 +A++II L K R + E R EKL++++E K G ++IASATG Sbjct 241 KAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATG 300 Query 271 KSYGDKVKLYRELLNFEVGYGINKLRDVVDVYDEIDRD---KVLEYVKLLGPGGLIFVSQ 327 + GD++KLYRELL FEVG G + LR+VVD Y + +D V E + LG GGLIFV Sbjct 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPV 360 Query 328 DYGLEVAKDIENLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMP 387 D GL A+++ N L E K ++V SK+K+ E F G+ D LIG A+YYG LVRG+D+P Sbjct 361 DQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLP 420 Query 388 ERVRYAIFYGIPKMKFKL-------------------------REYLEKVRKN-RKIDID 421 +RYA+F G+PK +F + R EK+ R++ + Sbjct 421 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRN 480 Query 422 IEGKSLEEIEDILKRDLKLRN-----------------------------------FSIK 446 I L +IE+ L L + N S+ Sbjct 481 IPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLV 540 Query 447 VEDDEIYILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHYESE 506 E+ + YI IPD++TYIQA+GRTSR+ G+TKG+S+L+VD+ K+F + + M + ++ E Sbjct 541 KEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQ-E 599 Query 507 FKSA--REVNFEELIKKIDEDREKIKLCMR---RGKVPDILKSILMVVESPNKARTIASF 561 FK E++ +E++++IDEDREK++L M KV D+++S LM+VESPNKARTIA+F Sbjct 600 FKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANF 659 Query 562 FGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYGVKIEDN----IYIPIY 617 FG+PS+ +I + YE+ +GD L I ASGGH+FDLVT EGY+GV I++ +IP+Y Sbjct 660 FGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVY 719 Query 618 MAIRKIN--GEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIATD 675 +++ G Q D + + + + S V + +N+ +REIA EVD + IATD Sbjct 720 DTLKRCRDCGHQFVDWEK-----KGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATD 774 Query 676 IDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQL 735 DTEGEKI +DI + P+ NI RI F+E+TR AI++A++ R ++EN+V +Q+ Sbjct 775 PDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEAR-----DVNENRVNAQI 829 Query 736 VRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEH-KKKVPYLSLKLEY 794 VRRIEDRWIGF+LS++L VF+ LSAGRVQTPVLGWIIERY+E + +V +L L LE Sbjct 830 VRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLEN 889 Query 795 DIYV----GKIWEGDFKGEEVEV-EVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVM 849 + V GK + E V V EV L R+++P+PP+TTD +L++A+ LS E M Sbjct 890 GLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETM 949 Query 850 RIAQDLFELGLTTYHRTSSTRVSL 873 R+AQDLFE GL T T VSL Sbjct 950 RLAQDLFEAGLCV---TPDTLVSL 970 Range 2: 1451 to 1703 Score:251 bits(640), Expect:7e-67, Method:Compositional matrix adjust., Identities:132/253(52%), Positives:182/253(71%), Gaps:7/253(2%) Query 862 TYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFI 921 TYHRT ST VS G++VA+EY+ E Y K R + EG HE IRPT+P+DTG L++ I Sbjct 1451 TYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLI 1510 Query 922 RENNI----SLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDI--DERIEGYVDVEF 975 R+ I +L++NH +LYD+IFRRF+ SQM A ++YE+ I +EGYV++ Sbjct 1511 RDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIE 1570 Query 976 DGWTRIYNLKLRKLPKIEKS-KLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYA 1034 DGWTR+ + LR+LPK+EK KLKV++ K KV LY +G+++ LMKER IGRPSTYA Sbjct 1571 DGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYA 1630 Query 1035 QIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERG 1094 +I++ L+ RGYV+++K + KL+PT+ GI+VY+YL++ Y L+SEE+TRELEEIMD+IE G Sbjct 1631 KIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEG 1690 Query 1095 EVDYIQVLHALKS 1107 DYI+VL L S Sbjct 1691 IEDYIKVLGELYS 1703 >RecName: Full=Reverse gyrase 2; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Sulfurisphaera tokodaii str. 7] Sequence ID: Q975P6.2 Length: 1233 Range 1: 9 to 1222 Score:662 bits(1709), Expect:0.0, Method:Compositional matrix adjust., Identities:473/1238(38%), Positives:678/1238(54%), Gaps:165/1238(13%) Query 6 YKEMCPNCFGEIYSSRLELG-VCERCLEEEERCSKL-DLCRKLGDKKKLDKLKGYCKVWN 63 Y CPNC I + RL G VC CLEE+ + + +L +L KL++L +V Sbjct 9 YLSSCPNCGRVISAERLYKGSVCSECLEEDREFNSIRELVNELSRLNKLNRLNYIKEVLR 68 Query 64 EFKKF-DRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLADRGK 122 E+ F + F + +G+ QK W RVL+ +SF+I+AP G+GK+ FG++ SLY + + Sbjct 69 EYDIFVELFKRIIGFPPFGPQKSWIIRVLRKESFAIIAPPGLGKTTFGIITSLYFSSKNF 128 Query 123 RCYIILPTTLLVKQTYERAQSLVG-DNI--KVVCYHSELSEREKRDIKKRIEEGDFQVLI 179 R +I PT LVKQ +R NI K++ YHS ++E +K+++ K + GDF + I Sbjct 129 RSILIFPTRSLVKQAVDRISMYSNKTNIETKLLYYHSGINESQKQELYKALNAGDFNIFI 188 Query 180 TTSNYLT---RNMPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKIILLM 236 T+ + + +DF+FVDDVD LKSSK+ + L L GFS+ D+ + L+ Sbjct 189 ATNRFFIDKINELKNIKYDFMFVDDVDTALKSSKSAETILNLAGFSK---DDILSVKELL 245 Query 237 KWRKFDKAL--ELREKLRKKLEGIKHGCIVIASATGKSYGDKVKLYRELLNFEVGYGINK 294 + + D+++ +++E KL+G IV +SAT + G+ V L+ F G + Sbjct 246 RKSREDESVYTKIQEIRGNKLKG---KTIVFSSAT-LTRGNPV--LSALMGFRPGSSVIY 299 Query 295 LRDVVDVYDEI---DRDKVLEYVKLL---GPGGLIFVSQDYGLEVAKDIENLLRENNIKA 348 LR ++D Y + D D V +LL G GGLIFV D G E AK +E L ++ Sbjct 300 LRKIIDTYAYLPNNDDDVVNLLKELLNKLGEGGLIFVPVDKGQEYAKFLEAKLSDS-FNV 358 Query 349 KVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKFKLREY 408 + S + EDF G I LIG A++YG+LVRG+D+P RV+YAIF GIPK KFK+ E Sbjct 359 VTITSSNTNKIEDFANGNIYALIGSATHYGILVRGIDIPWRVKYAIFVGIPKFKFKIGEV 418 Query 409 LEKVRKNRKI--------DIDI---------------------------EGKSLEEI--- 430 + V +R + D DI EGK +E Sbjct 419 MNLVALSRILSMIGLITKDQDIVRLAGRVRGKLRKLSPAAISMLTNQAREGKLEDETLLR 478 Query 431 -----------EDILKRDLKLRNFSIKVEDDEIYILIPDIKTYIQASGRTSRMTEFGLTK 479 +DILK+ +L + I YIL+PD TYIQASGRTSR+ LT Sbjct 479 AYEVVNKYLEDKDILKKIAELGDLVI----SNGYILMPDYLTYIQASGRTSRIYGGELTT 534 Query 480 GVSILLVDHWKLFESIEKYM------LFHYESEFKSAR--EVNFEELIKKIDEDREKIKL 531 G+S+LL+D LF + + + + E + K + + E+I KI+E+RE+I Sbjct 535 GLSVLLIDDINLFNILNRKLSLILDEIIWQELQIKKNKIGSSDLTEIINKINEERERILK 594 Query 532 CMRRGKV-PDI--LKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIIT 588 + G++ P + +K++L +VESPNKA+TI++FF +PS R++ I +E + D LI+ Sbjct 595 VKKEGEIEPSLQKVKTVLFIVESPNKAKTISNFFAKPSIRQLENIRAFETVLEDKILIVA 654 Query 589 ASGGHIFDLVTKE-GYYGVKIEDNI----YIPIYMAIRK-INGEQITDQKDIEEILRELI 642 A+GGH++DL T+ G YGV+++ +IP Y I+K ING Q TD + + Sbjct 655 ATGGHVYDLTTQNIGIYGVEVQQQNSHFNFIPYYNTIKKCINGHQFTDFEQGNQC----- 709 Query 643 EKGESVKVI-NCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRI 701 K + ++I + ++ +R++A E D + I TD DTEGEKI +DI L + PFN NI R Sbjct 710 PKCHTTQIILDKTATIDALRKLALEADEILIGTDPDTEGEKIAWDIYLALKPFNSNIKRA 769 Query 702 GFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKL----WEVFK 757 F+E+TR+AIL+A+ R + N VKSQ+VRRIEDRWIGFKLS KL W+ + Sbjct 770 EFHEVTRKAILQAINNPR-----PFNVNLVKSQIVRRIEDRWIGFKLSTKLQEDFWKEYC 824 Query 758 KNY---------LSAGRVQTPVLGWIIERYEEH---KKKVPYLSLKL--EYDIYVGKIWE 803 KNY LSAGRVQ+PVL WI+ RY+E+ K K+ Y S+K E YV K E Sbjct 825 KNYNCKSEENKNLSAGRVQSPVLNWIVNRYDEYNANKTKIYYGSIKGIDELKFYVFKQNE 884 Query 804 GDFKGEEVEVEV---NLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGL 860 K + V++ + +I+P PP+TTDTLL +A + + +S E M+IAQDLFELGL Sbjct 885 KIRKNANIYVKIINTKVLEEEINPLPPYTTDTLLYDANQFYGISASETMKIAQDLFELGL 944 Query 861 TTYHRTSSTRVSLEGMKVAREYLKLSNLEDY---LKNREFYMEGPHECIRPTKPMDTGEL 917 TYHRT STR+S G+ +A YLK E+Y K R + G HE IRPT+P+D +L Sbjct 945 ITYHRTDSTRISNTGISIAEGYLKQIAGENYTKIFKPRSWGEGGAHEAIRPTRPLDVDQL 1004 Query 918 IEFIRENNISLSKN----HIKLYDLIFRRFIASQMKEATVVYEEL--------------- 958 + E I L+K H +YDLIFRRFI SQ+ V+ E + Sbjct 1005 RLLVDEGEIELAKKITRAHFLIYDLIFRRFITSQLVPLKVIKERIEYKICEDSNCNSELK 1064 Query 959 -------YIKDIDERIE-GYVDVEFDGWTRIY-NLKLRKLPKIEKSKLKVLDYSIRKV-- 1007 +I DI I+ Y + TRI N ++KL + S L I+ Sbjct 1065 TLQNYSEFITDIKLPIQLDYSKFLYLPTTRIIKNSIIKKLQETTGSTNAELVSKIQLTGS 1124 Query 1008 ---NKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEV 1064 + V LY + E+V MK + IGRPSTYA II +L RGYVI+SK KLIPT+LG EV Sbjct 1125 FVKSTVNLYTQAELVAEMKRKEIGRPSTYATIISTILKRGYVIESKKTKKLIPTQLGKEV 1184 Query 1065 YNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVL 1102 YL + +SEE+TR L ++MD +E+G+ DYIQ+L Sbjct 1185 NKYLNQKFSSFVSEERTRNLLQLMDMVEQGKQDYIQIL 1222 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Sulfolobus acidocaldarius DSM 639] Sequence ID: Q08582.3 Length: 1248 Range 1: 9 to 1237 Score:660 bits(1703), Expect:0.0, Method:Compositional matrix adjust., Identities:472/1256(38%), Positives:683/1256(54%), Gaps:183/1256(14%) Query 3 PIIYKEMCPNCFGEIYSSRLELG-VCERCLEEEERCSKL-DLCRKLGDKKKLDKLKGYCK 60 P IY CPNC I + RL LG VC CLEE++ + DL + + + L KLK + Sbjct 9 PSIYLFSCPNCGRSISTYRLLLGSVCNICLEEDKEYKNIGDLIKDIEKQGNLIKLKDIQR 68 Query 61 VWNEFKKF-DRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLAD 119 V ++++ F F + LG+ QK W R+L +SF+I+AP G+GK+ FGL+ S+YL Sbjct 69 VLDDYESFVSVFRRLLGFPPFGPQKSWIYRLLSGESFAIIAPPGLGKTTFGLISSIYLYL 128 Query 120 RGKRCYIILPTTLLVKQTYERAQSLVGD-------NIKVVCYHSELSEREKRDIKKRIEE 172 RGK+ ++ PT LV+Q ++ S + + KV+ Y+S +S E+++ + ++ Sbjct 129 RGKKSILVFPTKSLVRQAIDKLSSYIQNLAEIKENPPKVIYYYSGMSASERKEADEGLQS 188 Query 173 GDFQVLITTSNYLTRNM---PPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFS---RELI 226 F + I+T+ +L N+ T++ F+FVDDVD LKSSK+ L LLGF+ ++ I Sbjct 189 KTFDIFISTNRFLIDNIDQISSTSYQFLFVDDVDTALKSSKSAQAILKLLGFTPSDQDKI 248 Query 227 DEAYKIILLMKWRKFDKALELREKLRKKLEGIK-----HGCIVIASATGKSYGDKVKLYR 281 E+ K K+R+ + E E + ++++ I+ ++ +SAT + Sbjct 249 KESLK-----KYRENTQKNEQNEYIFEEIDKIRKDRLASKTVIFSSAT---LNRSNPILT 300 Query 282 ELLNFEVGYGINKLRDVVDVY-DEIDRDK-----VLEYVKLLGPGGLIFVSQDYGLEVAK 335 L+ F+ G + +R V D+Y + D+++ + + LG GGLIFV D E K Sbjct 301 SLVGFKPGSSVIYIRKVYDMYVKQPDKEQETFNLIKSLLHRLGDGGLIFVPVDKKQEYIK 360 Query 336 DIENLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIF 395 +++ L N + S +DF G+IDVLIG A++YG+LVRGLD+P RV+Y+IF Sbjct 361 RLQSEL-SNEFNVAAITSTSATKIDDFANGEIDVLIGSATHYGILVRGLDLPWRVKYSIF 419 Query 396 YGIPKMKFKLREYL-----------------------------EKVRKNRKIDIDI---- 422 GIPK KF+L E + +K+R+ + + Sbjct 420 VGIPKFKFRLGEKVNLLTLSRLLSLIALITKDQEVIYISRRVKDKIRRLSPAALTMLSVQ 479 Query 423 --EGKSLEEI--------------EDILKRDLKLRNFSIKVEDDEIYILIPDIKTYIQAS 466 EGK + I +++LKR ++ +F + ++D ILIPD TY+QAS Sbjct 480 AKEGKLEDSILLKAYDLLNKYLSNQNVLKRISEIGDFVLSPDND---ILIPDYLTYVQAS 536 Query 467 GRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLF--------HYESEFKSAREVNFEEL 518 GRTSR+ +T G+SILLVD + LF + K + + + E +A +V + L Sbjct 537 GRTSRIYAGDVTTGLSILLVDDFNLFRLLNKKLQYILDDIQWRELDVEKWTAGDVEIKNL 596 Query 519 IKKIDEDREKIKLCMRRGKVPDIL---KSILMVVESPNKARTIASFFGRPSRRKIRGINV 575 I KI+E+R +I G V L K++L+VVESPNKA+TI+SFF RPS R+I + V Sbjct 597 ISKINEERNEISKLKNEGNVAPALQKVKTVLLVVESPNKAKTISSFFSRPSIRQIGNMRV 656 Query 576 YEVCIGDINLIITASGGHIFDLVTKE-GYYGVKIEDN----IYIPIYMAIRKI-NGEQIT 629 YE +GD L++TASGGH++DL T++ G YGV I ++IPIY +I+K N Q T Sbjct 657 YETVLGDKVLMVTASGGHVYDLTTQDMGIYGVDIMKQNSSLVFIPIYNSIKKCENNHQFT 716 Query 630 DQKDIEEILRELIEKG--ESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDI 687 D + + R + K +S+K IN +R +A E D V I TD DTEGEKI +D+ Sbjct 717 DFFESNKCPRCMTTKVRYDSLKSINV------LRNLAVEADEVLIGTDPDTEGEKIAWDL 770 Query 688 GLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFK 747 L + P+N NI R F+E+TR+AIL+A+ R + + N VKSQLVRRIEDRWIGFK Sbjct 771 YLALRPYNSNIRRAEFHEVTRKAILQAINQPR-----EFNVNLVKSQLVRRIEDRWIGFK 825 Query 748 LSEKLWEVFKKNY-----------------LSAGRVQTPVLGWIIERYEEH---KKKVPY 787 LS L F Y LSAGRVQTPVL WI++RY E+ K +V Y Sbjct 826 LSSILQTRFWPEYCKSLSSNKQLNCNENKNLSAGRVQTPVLSWIVDRYTEYQRNKSRVYY 885 Query 788 LSLKLEYDI--YVGKIWEGDFKGEEVEV---EVNLYSRDISPSPPFTTDTLLEEATKRFN 842 + DI YV K +G K ++ V E+N + P PP+TTDTLL ++ F Sbjct 886 GKIDQLQDIVIYVPK-QDGVRKNSKIVVVFNEINQLEEEFGPLPPYTTDTLLSDSNNFFG 944 Query 843 LSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDY---LKNREFYM 899 LS E MRIAQDLFELGL TYHRT S R+S G+ VA YLK + Y K R + Sbjct 945 LSAPETMRIAQDLFELGLITYHRTDSNRISNTGISVAENYLKDVLGDKYTNIFKPRSWGD 1004 Query 900 EGPHECIRPTKPMDTGELIEFIRENNIS----LSKNHIKLYDLIFRRFIASQMKEATVVY 955 G HE IRPTKP+D +L I E + L+ NH K+YD+IFRRFI+SQ+ V Sbjct 1005 GGAHEGIRPTKPIDVEQLRLLIEEGELELAKRLTNNHFKVYDIIFRRFISSQIIPLKVRK 1064 Query 956 E----ELYIKDIDERIEGY--------------VDVEFDGWTRIYNLKLRKLPKIEKSKL 997 E ELY ++ E+I +D E + + +R + + +L Sbjct 1065 EIVKIELYGENKKEKINSNQNIIEVITGITLPGIDTEISKFAYV---PVRNVSRSVAERL 1121 Query 998 KVL------DYSIRKVNK-----VPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYV 1046 K L D+SI N V LY + ++V MK + IGRPSTYA II +L RGYV Sbjct 1122 KELGRSIPTDFSIEISNSFIKSTVNLYTQADLVMEMKNKKIGRPSTYATIIGTILRRGYV 1181 Query 1047 IKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVL 1102 ++S KLIPT+LG+EV YL +Y +SE++TR+L ++MD +E G+ Y +VL Sbjct 1182 LESLKTKKLIPTRLGVEVNKYLNENYGRFVSEDRTRKLLQLMDMVEAGQEKYEEVL 1237 >RecName: Full=Reverse gyrase 1; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Aeropyrum pernix K1] Sequence ID: Q9YCB6.2 Length: 1370 Range 1: 11 to 1315 Score:658 bits(1698), Expect:0.0, Method:Compositional matrix adjust., Identities:463/1321(35%), Positives:694/1321(52%), Gaps:236/1321(17%) Query 5 IYKEMCPNCFGEIYSSRLELGV-CERCLEEEER---CSKLDLCRKLGDKKKLDK-LKGYC 59 +Y+ +CPNC G RL G+ C RCL R L R L + L +K Sbjct 11 VYRYLCPNCGGPNSEERLSRGLPCPRCLPRLPRKGVSGWTGLARLLRREGTLGAGVKAMA 70 Query 60 KVWNEFKKFDRFC-KELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLA 118 + E + RF K +G Q+ WAKR+ + SFSI+APTGVGK+ FG SL+ A Sbjct 71 SLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAASLFYA 130 Query 119 -DRGKRCYIILPTTLLVKQTYERAQSLVGDN----IKVVCYHSELSEREKRDIKKRIEEG 173 +G R YI+LPTT L + +S+V ++++ HS+L E+R+ +R E+G Sbjct 131 CKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAMERFEKG 190 Query 174 DFQVLITTSNYLTR---NMPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAY 230 DF +L+TT+ + + + F +FVDDVDA+L+S++++D L ++GF E I++ Sbjct 191 DFDILVTTAAFARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEEAIEKGL 250 Query 231 KIILLMKWRKFDKAL------ELREKLRKKLEGIKH----------------GCIVIASA 268 +++ L + + L E+RE+ RKKL +K ++++SA Sbjct 251 EVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIEARRGRTASLIVSSA 310 Query 269 TGKSYGDKVKLYRELLNFEVG-YGINKLRDVVDVYDEID---RDKVLEYVKLLGPGGLIF 324 TG+ G +V+L+R LLNFE G G LR V+D Y +KV+E V+ LG GGL++ Sbjct 311 TGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRRLGTGGLVY 370 Query 325 VSQDYGLEVAKDIENLLRENNIKAKVVHSKDK-EGFEDFRTGKIDVLIGVASYYGVLVRG 383 V D G+E A+ + LR +KA+ H+K E + F G+IDVL+GVA+YYG LVRG Sbjct 371 VPIDMGVEYAERLAEELRRAGVKAEAYHAKKPLELLDRFAEGEIDVLVGVANYYGTLVRG 430 Query 384 LDMPERVRYAIFYGIPKMKF-----------------------------KLREYLEKVRK 414 LD+P RVRYA+F G+P+ KF R ++ ++R+ Sbjct 431 LDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASAARSHMGRLRR 490 Query 415 --------------NRKIDIDIEG-------KSLEEIEDILKRD-----LKLRNFSIKVE 448 R ++EG ++ + + + L RD L+ + I E Sbjct 491 MLRVLSPAALQMIAERVARGEVEGGYDRQVLEAYQFLREALARDDVWESLRELDVGIVRE 550 Query 449 DDEIYILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHYESEFK 508 YIL+PD TY+QASGRTSR+ G+T G+S+++VD+ + + K + + E +++ Sbjct 551 GGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMRGLMKRVSWMAEVDWR 610 Query 509 SAREVNFEELIKKIDEDREKIKLCMR---RGKVPDILKSILMVVESPNKARTIASFFGRP 565 +++ + ++++IDEDREK++ ++ RG +++++ L+VVESPNKARTIA FFG+P Sbjct 611 RFEDLDLQSILREIDEDREKVRRVVKGLYRGV--ELVRTALLVVESPNKARTIARFFGQP 668 Query 566 SRRKIRGIN-VYEVCIGDINLIITASGGHIFDLVTK--------------EGYYGV---K 607 S R + G VYEV GD L+I ASGGH+FDLV + +GV + Sbjct 669 SVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEAAGGEPEHAIFGVLRYR 728 Query 608 IEDN---IYIPIYMAIRKI--NGEQITDQKD-IEEILRELIEKGESVKVINCRDNMETIR 661 + N Y P+Y +I++ G Q D+ ELI N +E +R Sbjct 729 LGGNGAAAYTPVYTSIKRCLDCGYQFVDEASRCPRCGSELIR--------NSLSTVEDLR 780 Query 662 EIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRG 721 +A E D V++ TD DTEGEKIG+D+ L + P+ +I R+ F+E+T++AIL A+ R Sbjct 781 RVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAILEALSNPR-- 838 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNY--------------------- 760 D+N V +Q+VRR+EDRWIGF LS LW F Y Sbjct 839 ---SFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMDRERCA 895 Query 761 -------LSAGRVQTPVLGWIIERYEEHKKKV-------------PYLSLKLEYDIYVGK 800 LSAGRVQTP LGW+++R ++KKV S E V + Sbjct 896 KYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVPESVKR 955 Query 801 I---WEGDFKGEEVEVEVNLYS-------RDISPSPPFTTDTLLEEATKRFNLSTEEVMR 850 + W K +E +++ + + P PP+TTDT+L +A + L + E MR Sbjct 956 VLDNWVKHHKKTGIEPWLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGSAEAMR 1015 Query 851 IAQDLFELGLTTYHRTSSTRVSLEGMKVAREYL--KLSNLEDYL-KNREFYMEGPHECIR 907 IAQDLFE GL TYHRT STRVS GM+VARE+L + L L + R + G HE IR Sbjct 1016 IAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGAHEAIR 1075 Query 908 PTKPMDTGELIEFIRENNI----SLSKNHIKLYDLIFRRFIASQMKEA---TVVYEELYI 960 P +P+D L + E I +L++ H++LYDLIFRRF+ASQM+EA VVY L + Sbjct 1076 PVRPIDVERLQLLVEEGVIELPGTLTRRHLRLYDLIFRRFMASQMREADALRVVY-RLRV 1134 Query 961 KDIDE---RIEGYVDV----EFDGWTRIYNL---KLRKLPKIEKSKLKVLDYSI--RKVN 1008 ++D +E V++ + +G TR + L +R P++ + + + + R+V Sbjct 1135 PELDGYTLTLERVVEIGRPGDAEGVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGRQVP 1194 Query 1009 KVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVI-----KSKNKGKLIPTKLGIE 1063 K Y EGE+V+ MK RGIGRPSTYA+I++ L R YVI + + G ++ T GI Sbjct 1195 KAYPYTEGEIVEEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGIN 1254 Query 1064 VYNYL-------------------ITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHA 1104 VYNYL + P L+SE++TRELE MD +E+G+ VL + Sbjct 1255 VYNYLTEELRSADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLES 1314 Query 1105 L 1105 + Sbjct 1315 V 1315 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase; Contains: RecName: Full=Pho r-Gyr intein [Pyrococcus horikoshii OT3] Sequence ID: O58530.1 Length: 1624 Range 1: 4 to 982 Score:656 bits(1693), Expect:0.0, Method:Compositional matrix adjust., Identities:407/1002(41%), Positives:590/1002(58%), Gaps:137/1002(13%) Query 5 IYKEMCPNCFGEIYSSRLE-LGVCERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCKVWN 63 IY+ MCPNC G I RL CE CL E D + + KL+G K W Sbjct 4 IYRGMCPNCRGAITDERLSNKNPCEGCLSEPILSE--DYNELIVAVRNALKLRGTLKDWE 61 Query 64 EFKKFDR--------FCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSL 115 E + ++ F K G++ S Q+ W KR+++ KSFSI+APTG+GKS FG +S+ Sbjct 62 ELYRLNKEVSEIEELFEKSTGFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISI 121 Query 116 YLADRGKRCYIILPTTLLVKQTYERAQSLV---GDNIKVVCYHSELSEREKRDIKKRIEE 172 Y A +GK+ YI++PTT LV QT ++ +S++ ++++V YH L ++EK + ++I Sbjct 122 YFATKGKKSYIVVPTTPLVIQTVKKIESMLEKANVSVRLVYYHGNLRKKEKEEALEKIRN 181 Query 173 GDFQVLITTSNYLTRN----MPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDE 228 GDF +LIT+S +L + FD IFVDDVDA LK+SKNIDR+L++LGFS E+I Sbjct 182 GDFDILITSSQFLATRFKELLKDKKFDLIFVDDVDAFLKASKNIDRSLIMLGFSEEIIGR 241 Query 229 AYKIIL---------------------LMKWRKFDKALELREKLRKKLEGIKHGCIVIAS 267 A+++I L K + + K R K+ G +++AS Sbjct 242 AWEVIKLKKQLAKLLQNEKKNEEEIEKLNKEIEKIEDEIEEYKRRNKI-----GILIVAS 296 Query 268 ATGKSYGDKVKLYRELLNFEVGYGINKLRDVVDVY---DEIDRDKVLEYVKLLGPGGLIF 324 ATG + GD++KLYRELL FEVG G + LR++VD Y ++ + V+E ++ LG GGLIF Sbjct 297 ATGSAKGDRIKLYRELLGFEVGSGRSVLRNIVDTYLLPEKPIEEHVVELLRKLGKGGLIF 356 Query 325 VSQDYGLEVAKDIENLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGL 384 V D G+E A+++ + L+ K ++V +K+K+G E F G+ID L+GVA+YYG LVRGL Sbjct 357 VPIDKGIEYAEELTDYLKSQGFKVELVSAKNKKGLELFEKGEIDYLVGVATYYGTLVRGL 416 Query 385 DMPERVRYAIFYGIPKMKFKLR-----------------EYLEKVRKN---------RKI 418 D+P +R+AIF G+PK +F + E+L + +K+ R++ Sbjct 417 DLPHLIRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEEKKSEGEKLYARLRRL 476 Query 419 DIDIEGKSLEEIEDILKRDLKLRNF----------------------------------S 444 +I L +IE+ L L+L F S Sbjct 477 IRNIPQYELMKIEEALAEGLELEGFHNHVLEVFKQSVEFLREVLKDEEVIKKIAENPFLS 536 Query 445 IKVEDDEIYILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHY- 503 +K + ++YI IPD++TYIQASGRTSR+ G+TKG+S+++VD K+F + + M + + Sbjct 537 LKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFV 596 Query 504 ESEFKSAREVNFEELIKKIDEDREKIKLCMR---RGKVPDILKSILMVVESPNKARTIAS 560 E + K EVN +E++K+ID DREK+KL + +V D++KS LM+VESPNKARTIAS Sbjct 597 EFDIKKFEEVNLKEVLKEIDRDREKVKLVIEGKISEQVKDLVKSALMIVESPNKARTIAS 656 Query 561 FFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYGVKIEDN----IYIPI 616 FFG+PS+RKI + YEV IGD L I ASGGH+FDLVT EGY+GV I N ++P+ Sbjct 657 FFGQPSKRKIGDLTAYEVSIGDKMLTILASGGHMFDLVTNEGYHGVLILKNNGKPYFVPV 716 Query 617 YMAIRKIN--GEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIAT 674 Y I++ G Q D + + + + S V + +N++ +RE+A EVD + I T Sbjct 717 YDTIKRCRDCGHQFVDWEQ-----KGVCPRCGSRNVHDALENVKAMRELALEVDEILIGT 771 Query 675 DIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQ 734 D DTEGEKI +DI + P+ NI RI F+E+TR AILRA+ R ++E++V +Q Sbjct 772 DPDTEGEKIAWDIRNVLAPYAPNIKRIEFHEVTRPAILRAIREAR-----DINEDRVNAQ 826 Query 735 LVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEH-KKKVPYLSLKLE 793 LVRRIEDRWIGF+LS+KLWEVF+ LSAGRVQTPVLGWI++RY+E + + +L + LE Sbjct 827 LVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGIILE 886 Query 794 YDIYVGKIWEGDFKGEEVEVEVN---LYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMR 850 I V + KGE EVEV + +D++P PP+TTDT+L++A++ S + M+ Sbjct 887 NGINVTI---ENAKGEVREVEVKDVIIEEKDVNPLPPYTTDTMLQDASRFLGFSATKTMQ 943 Query 851 IAQDLFELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYL 892 +AQDLFE GL T T VSL ++ + N E+ L Sbjct 944 LAQDLFEAGLCV---TPDTLVSLSDGRIIEIREAVENSEESL 982 Range 2: 1365 to 1615 Score:259 bits(662), Expect:1e-69, Method:Compositional matrix adjust., Identities:134/253(53%), Positives:185/253(73%), Gaps:11/253(4%) Query 862 TYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFI 921 TYHRT S VS G++VA+EY+ E+Y R++ EG HE IRPT+P+DTG LI+ I Sbjct 1365 TYHRTDSIHVSNTGIEVAKEYITQEIGEEYFTPRKWGEEGAHEAIRPTRPIDTGRLIQLI 1424 Query 922 RENNISLSKN----HIKLYDLIFRRFIASQMKEATVVYEELYI----KDIDERIEGYVDV 973 R+ I++ KN H +LYDLIFRRF+ASQMK A ++YE+ I KD++ +EGY+DV Sbjct 1425 RDGIITIPKNLTRDHFRLYDLIFRRFMASQMKPAKILYEKAIISTPFKDVE--VEGYIDV 1482 Query 974 EFDGWTRIYNLKLRKLPKIEKS-KLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPST 1032 +DGW++I +L LR++PK+EK +L+V + + KV LY +G+V+ LMKERGIGRPST Sbjct 1483 LYDGWSKIKSLPLRQIPKLEKGQRLRVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPST 1542 Query 1033 YAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 YA+I++ LL RGYVI++K K KL+PT+ GI+VY YLIT Y L+SEE+TR+LE+IMD +E Sbjct 1543 YAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLITKYKDLVSEERTRQLEKIMDMVE 1602 Query 1093 RGEVDYIQVLHAL 1105 + DY VL+ L Sbjct 1603 EAKADYQDVLNEL 1615 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Caldanaerobacter subterraneus subsp. tengcongensis MB4] Sequence ID: Q8R979.1 Length: 1117 Range 1: 9 to 1106 Score:646 bits(1666), Expect:0.0, Method:Compositional matrix adjust., Identities:442/1147(39%), Positives:661/1147(57%), Gaps:96/1147(8%) Query 6 YKEMCPNCFGEIYSSRLELGV-CERCLEEEERCSKLDLCRKLGDKKKLDKLKGYCKVWN- 63 Y C NC G +R E G+ CE CL E+ D+ + L K + LKGY K WN Sbjct 9 YYHSCINCGGINTDTRNEKGLPCEVCLPFEDG----DVLKGL---KLNNSLKGYEKYWNL 61 Query 64 --EFKKFDRFC------KELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSL 115 ++K+F+ F K GY Q+ WAKR+L +KSF++VAPTGVGK+ FGL+ +L Sbjct 62 NQQYKEFEEFFFSKINKKPTGY-----QRFWAKRLLLSKSFTLVAPTGVGKTTFGLISAL 116 Query 116 YLADRGKRCYIILPTTLLVKQTYER--AQSLVGDNIKVVCYHSELSEREKRDIKKRIEEG 173 ++A +G + ++ PT LV+Q +R S +++ ++ Y S L ++E+ +K EG Sbjct 117 WIAKKGGKVALVFPTVSLVEQAAKRLIEFSKEDEDVNILFYTSSLKKKEREKFEKNFSEG 176 Query 174 DFQVLITTSNYLTR---NMPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAY 230 ++ +L+ +S ++++ + FD +FVDDVDA+LKSSKNID L ++G S++ ID Sbjct 177 NYDILVISSQFISKRKEQLSQKVFDLVFVDDVDAVLKSSKNIDTLLNMIGISQKAIDST- 235 Query 231 KIILLMKWRKFDKALELREKLRKKLEGIKHGCIVIASATGKSYGDKVKLYRELLNFEVGY 290 + L K DK +++ EK K G ++++SAT K G K L+RELL FE+G Sbjct 236 -LDNLKKGNNSDK-IQIEEKAPK-------GRLIVSSATAKPKGIKPLLFRELLGFEIGR 286 Query 291 GINKLRDVVDV-YDEIDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLLRENNIKAK 349 R++ +V E +K+L + LL G L+FV + E K+I N L E+ +K Sbjct 287 FTTSARNITNVRIKEKSLEKLLYIINLLKDGILLFVPTE---EEGKEIANYLEEHGVKLG 343 Query 350 VVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKFK----- 404 ++ FE F+ G + +L G+ SYYG LVRG+D+P R+++A+F+G P KF Sbjct 344 KTWEDFEKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFSTKLEN 403 Query 405 ---------LREYLEKVRKNRKIDIDIEGKSLEEIEDILKR--------DLKLRNF-SIK 446 ++YLE K + D++ S E++ +++ L +NF + K Sbjct 404 APRFILERNFQDYLENNPKLKAYFKDLQRLSTEKLRKSVEKYISPETWEKLIQKNFPTTK 463 Query 447 VEDDEIYILIPDIKTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHYESE 506 + ++ I+IPD+ TYIQASGRTSR+ LTKG+SIL + LFE ++ +L Y +E Sbjct 464 FDKEKNLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFEEDDSLFELLKARLL--YLTE 521 Query 507 FKSAREVNFEELIKKIDEDREKIKLCMRRGKVPDILKSILMVVESPNKARTIASFFGRPS 566 + E E L+K+ +E R+ I +KS +++VESP KA+TI+ F + S Sbjct 522 EEWTEEGEIEHLVKEAEETRKAIST----DSSSKDMKSRMIIVESPTKAQTISKFLEKSS 577 Query 567 RRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYGVKIEDNIYIPIYMAIRKIN-- 624 R+ + V+E + L++TAS GH++DL TK G +GV+I D +IP Y +I++ + Sbjct 578 TRRYGSLMVHESITQEGILLLTASKGHLYDLETKTGLHGVEINDGRFIPYYNSIKRCSSC 637 Query 625 GEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIG 684 G Q TD E+ R S K+ + + +E +R+IA EVD V IATD D EGEKIG Sbjct 638 GAQFTD-----ELPR--CPYCNSDKIDDKKKILEALRDIAMEVDEVIIATDPDVEGEKIG 690 Query 685 YDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWI 744 +DI I P N+N+ RI +EIT+ +A+ R D N VKSQ+VRRIEDRW+ Sbjct 691 WDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRN-----CDVNLVKSQIVRRIEDRWV 745 Query 745 GFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKKKVPYLSLKLEYDIYVGKIWEG 804 GF+LS +L + F+ + LSAGRVQ+ VLGWI+E+ EH K ++ ++ + G +E Sbjct 746 GFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIEHSKSKKTVT---QFTLDNGFKFEV 802 Query 805 DFKGEEVEVEVNLYS---RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLT 861 D K + EVEV + + +SP PPF T +LL A+++F L +++M I Q LFELG Sbjct 803 DGKIDVDEVEVEIVEEKEQALSPLPPFNTPSLLTAASQQFKLPVQQIMEILQTLFELGFI 862 Query 862 TYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFI 921 TYHRT STR+S G K+AR YL+ L RE+ EG HE IRP KP+ EL EFI Sbjct 863 TYHRTDSTRISSTGQKIARSYLEKIGKITLLSEREWGKEGAHEAIRPVKPISPEELSEFI 922 Query 922 RENNIS-LSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDVEF--DGW 978 E + LS HIK+Y LIF RF+ASQM V+ +++ IK+ ++E V V+ +GW Sbjct 923 TEKIAAYLSPMHIKVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQEEGW 982 Query 979 TRIYNLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIK 1038 I+N P E+ K V+ + VPL+ + +++ M++R IGRPSTYA+I+ Sbjct 983 N-IFNPITVYTP-FEEKKYSVVSKRTYTTHTVPLFTQASLIEEMQKRNIGRPSTYAKIVD 1040 Query 1039 KLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDY 1098 L R Y+I+ K +L T LG +VY+YL Y + I+EE TR+LE++M+ +E GE DY Sbjct 1041 ILFKRKYIIEDVYK-RLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVETGEKDY 1099 Query 1099 IQVLHAL 1105 VL L Sbjct 1100 QSVLKNL 1106 >RecName: Full=Reverse gyrase 2; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Aeropyrum pernix K1] Sequence ID: Q9YC75.2 Length: 1215 Range 1: 8 to 1198 Score:622 bits(1604), Expect:0.0, Method:Compositional matrix adjust., Identities:425/1223(35%), Positives:644/1223(52%), Gaps:148/1223(12%) Query 5 IYKEMCPNCFGEIYSSRLELGV-CERCLEEEER-CSKLDLCRKLGDKKKLDKLKGYCKVW 62 +Y +C NC G I RLE G+ C RCL R + L + R L KK L Y + Sbjct 8 VYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPRRATPLTVYRAL---KKAGTLGAYSWEY 64 Query 63 NEFKKFDRF----CKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSLYLA 118 ++ +RF + G L S Q+ WAKR++K SF+I+APTGVGKS + + Y+A Sbjct 65 LSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYVA 124 Query 119 D--RGKRCYIILPTTLLVKQTYERAQSLVGDNIKVVCYHSELSEREKRDIKKRIEEGDFQ 176 RG+ Y++ PT LV+Q Y + + + Y+S + + + ++I G + Sbjct 125 AVKRGRVLYLV-PTENLVRQVYAKLDQV--EPGIATAYYSRMPAKARESSLEKIASGGAR 181 Query 177 VLITTSNYLTRNM----PPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKI 232 +++ T+ +L+R P FD VDDVD+LL++S+N++R LLL GFS E ++ A+ + Sbjct 182 LIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEETVEAAHSL 241 Query 233 I--LLMKWRKFDKAL-------------ELREKLRKKLEGIKHGCIVIASATGKSYGDKV 277 + L +R +L +LR L G +VIASATG+ G K Sbjct 242 VKARLKLYRALHSGASESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASATGRPRGVKH 301 Query 278 KLYRELLNFEVGYGINKLRDVVDVYDEIDRDKV---LEYVKLLGPGGLIFVSQDYGLEVA 334 L++ELL FEVG G + LR++VD Y +D D V E V LG G ++FVSQ G +VA Sbjct 302 LLFKELLGFEVGGGSDYLRNIVDAY-VVDSDPVGRTAEIVSALGDGVIVFVSQRLGKDVA 360 Query 335 KDIENLLRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAI 394 + I L + + + + E F G+ VLIG+AS YGV+VRGLD+PER +YA+ Sbjct 361 RAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLDLPERSKYAV 420 Query 395 FYGIPKMKFKLREYL--------------------------------EKVRKNRKIDIDI 422 F G P K L E L EKV + + Sbjct 421 FLGAPSAKTHLLEALYSPRRMLAFLSIAQEKGVEWAGEAFRRLSRLLEKVIDTSIVSLAA 480 Query 423 EGK----------------SLEEIEDILKRDLKLRNFSIKVEDDEI-------YILIPDI 459 GK + + D L + +L+ ++V + Y+++PD Sbjct 481 RGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGLVVDARGPIPYLVVPDA 540 Query 460 KTYIQASGRTSRMTEFGLTKGVSILLVDHWKLFESIEKYMLFHYESEFKSAREVNFEELI 519 TYIQASGR SR+ +T+G+SI++ + + E++ + + + S + EV+ E+L Sbjct 541 PTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWTTSSRLRPLSEVDMEKLR 600 Query 520 KKIDEDREKIKLCMRRGKVPDILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVC 579 ++I+E R + +K+ L+VVESP KARTIA F+GRP +R+I +YE Sbjct 601 REIEESRRGKGRRV-------RVKTTLLVVESPTKARTIAWFWGRPGKRRIGRSVIYEAS 653 Query 580 I-----GDINLI-ITASGGHIFDLVTKE--GYYGVKIEDNIYIPIYMAIRKI--NGEQIT 629 + GD++++ IT++ GH+ DL T YGV + Y Y I++ G Q T Sbjct 654 VSDPETGDVHILQITSTRGHLTDLTTDSVGSKYGVDEDGGGYRAYYSTIKRCLDCGAQHT 713 Query 630 DQKDIEEILRELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGL 689 + S + ++ + +E +R++A EVD + IATD D EGEKI +D+ L Sbjct 714 SSSP-------FCPRCGSPRQVDSKSVVEILRKLASEVDEIVIATDPDREGEKIAWDVFL 766 Query 690 NILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLS 749 + P+N N+ R F+E+T RA+ +EA R GE ++++ +++Q VRRI DRWIGF LS Sbjct 767 AVRPYNPNVRRGRFHEVTPRAV---IEALRSGE--SVEKSLIEAQKVRRIVDRWIGFHLS 821 Query 750 EKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKKKVPYLSL-KLEYDIYVGKIWEGDFKG 808 L F K +L AGRVQTPVLGWI++RY E + YL + KL + + Sbjct 822 THLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGGRTSYFTQNRLEV 881 Query 809 EEVE-------VEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLT 861 E ++ V++ + + +P PP+TTD L +A+++ LS M+IAQDLFE GL Sbjct 882 ENLKRVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKIAQDLFESGLI 941 Query 862 TYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFI 921 TYHRT STRVS G+K+A EYL LE + R + G HE IRP +P+D +L + Sbjct 942 TYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAV 1001 Query 922 RENN----ISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDVEFDG 977 + I L++ HI++YD+IFRRFIASQMK AT+ E ++ G G Sbjct 1002 LSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQ------AGETVFNHAG 1055 Query 978 WTRIY-NLKLRKLPKIEK--------SKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIG 1028 R+ L P++E+ ++ V D + K + LY G++VK+M+E GIG Sbjct 1056 VARVRGGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMREHGIG 1115 Query 1029 RPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIM 1088 RPSTYA+ I++ GYVI+SK LIPTK G+ +Y+YL + L+S + TR LEE + Sbjct 1116 RPSTYAKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEAL 1175 Query 1089 DKIERGEVDYIQVLHALKSICDQ 1111 +++E+G VL ++ + D+ Sbjct 1176 ERVEKGVEKPEAVLASVWRMVDE 1198 >RecName: Full=Reverse gyrase; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Saccharolobus shibatae] Sequence ID: P74759.1 Length: 1166 Range 1: 1 to 1146 Score:600 bits(1546), Expect:0.0, Method:Compositional matrix adjust., Identities:432/1195(36%), Positives:645/1195(53%), Gaps:142/1195(11%) Query 1 MIPIIYKEMCPNCFGEIYSSRLELGV-CERCLEEEERCSKLDLCRKLGDKKKL----DKL 55 MI ++YK CPNC G+I + RL G+ CE CL +D K+ + DK+ Sbjct 1 MINVMYKNSCPNCGGDISADRLLNGLPCETCLPYINGIDGIDHISKVKALYNILLDNDKI 60 Query 56 KGYCKVWNEFKKFDR----FCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGL 111 K Y ++ F+ F + GYE S+QK+W +R++ N+SF++ APTG+GK+ + Sbjct 61 KNYWNLYYNITTFETVFKYFKDKTGYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLM 120 Query 112 LMSLYLADRGKRCYIILPTTLLVKQTYERAQSLVGDNIKVVCYHSELSEREKRDIKKRIE 171 S+++ G+ I+PT L++Q +R + L +V C ++ +R Sbjct 121 TYSVFI---GQDVVYIVPTKSLMEQVCKRLEKL---GAQVSC--GKVDQR---------- 162 Query 172 EGDFQVLITTSNYLTRNMPPTTF---DFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDE 228 +V + T +YL +N T +F+ +DD DA++KS K DR + LLG ++ + Sbjct 163 ----KVSVITISYLNKNADSITSYKPNFVAIDDADAVIKSGKTTDRLVSLLGIPNDVYES 218 Query 229 AYKIILLMKWRKFDKAL--ELREKLRK---KLEGIKH--GCIVIASATGKSYGDKVKLYR 281 A ++I L F E++EK+R+ K+ K +VIASAT + G K K R Sbjct 219 AIQLIRLRNKYYFSNEFTEEIKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALR 278 Query 282 ELLNFEVGYGINKLRDVVDVY-DEIDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENL 340 L FE R+++D Y D +D L +K LG GGLI VS++YG +I+ Sbjct 279 LLTGFEPSSIQLYARNIIDTYTDNLD----LSIIKELGSGGLILVSKEYGRSRLNEIKKY 334 Query 341 LRENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPK 400 + + AK+ S ++ +DF GK+D+L+G ASYYGV VRG+D P+R++Y I+YG+PK Sbjct 335 VEDLGFNAKLAIS-GRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPK 393 Query 401 MKFKLREYLEK----VRKNRKIDID-----------------------IEGKSL------ 427 +K KL + L +R + I ++ I+G+++ Sbjct 394 IKAKLFDALSNPFTLLRVGKMIGVNFSELQNKILVLSPSEAQLLKFSIIKGETINYQKLE 453 Query 428 --------------EEIEDILKRDLKLRNFSIKVEDDEIYILIPDIKTYIQASGRTSRMT 473 +++++I + L NF I ++ YI+ PD+ TY+Q SGR SR+ Sbjct 454 QLRQELLYYISLVKDKLKEIGEETLISDNFVIAKQNTNYYIIYPDMITYLQGSGRASRLY 513 Query 474 EFGLTKGVSILLVDHWKLFESIEKYM--LFHYESEFKSAREVNFEELIKKIDEDREKIKL 531 GLT G SI+LVD +FE ++K M LF + F S +N E+ K++E R++ Sbjct 514 NGGLTLGFSIILVDDKHIFEILKKKMQKLFP-NTNFTSLSNINLSEIKTKLEESRKE--- 569 Query 532 CMRRGKVPDILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLI----I 587 +V + + L++VESP KA+TIA F RPS R I + VYE I D N I + Sbjct 570 --EGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRVINKVPVYETIIVDGNQIYVLDV 627 Query 588 TASGGHIFDLVTKE-GYYGVKIE-DNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKG 645 AS GHI DL ++ GYYG+KIE I P Y I+K D I + Sbjct 628 VASKGHIVDLTLEDIGYYGIKIEYSGIIKPYYDLIKKC-----LDCNKTFSIASDKCPYC 682 Query 646 ESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNE 705 S V + + +RE+A VD VFIA+D DTEGEKI YD+ + P+N NIYRI ++E Sbjct 683 GSTNVQTAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNIYRITYHE 742 Query 706 ITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGR 765 IT++AIL A+ +K++ N V SQ+VRRIEDRWIGF LS L F + AGR Sbjct 743 ITKKAILEALR-----NPMKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGR 797 Query 766 VQTPVLGWIIERYEEHKKKVPYLSLKLEYDIYVGKIWEGDFKGEE--------VEVEVNL 817 VQTPVLGWI+++ ++K + Y+ + ++ Y K+ + K E V++E + Sbjct 798 VQTPVLGWIVDKTIKYKSAMGYV-VYIDIAGYPIKMHFSERKKMEEYINNLQVVKIE-KI 855 Query 818 YSRDI--SPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEG 875 + I SP PPFTTDTLL EA ++ L VM+IAQDLFE GL TYHRT ST +S G Sbjct 856 FEEKILLSPLPPFTTDTLLIEANMKYKLPANLVMKIAQDLFEAGLITYHRTDSTHISSVG 915 Query 876 MKVAREYLKLSNL-EDYL-KNREFYMEGPHECIRPTKPMDTGELIEFIREN----NISLS 929 +++A+EYL+ L +D++ ++ E EG HE IRPT+ +D ELI+ I EN +I S Sbjct 916 IEIAKEYLQKQGLIKDFVPRSWESSEEGAHEAIRPTRAIDVNELIQEIEENPYKYSIRFS 975 Query 930 KNHIKLYDLIFRRFIASQMKEATVVYEELYIK-DIDERIEGYVDVEFD-GWTRIYNLKLR 987 K H +YDLIFRRF+ASQM A IK + ++ I + + G+ ++Y +K+ Sbjct 976 KLHFLIYDLIFRRFMASQMSHAVGTKSRYLIKLNKNDNINAELLSNAEGGFIKVYPVKVY 1035 Query 988 KLPKIEKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVI 1047 LP + + K KV + K + L +V+ LMK +GIGRPSTYA+ I+ L+ GY++ Sbjct 1036 NLP-LGEVKPKV---NTGKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLVRHGYIV 1091 Query 1048 KSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVL 1102 SK K LI T GI Y +L + + L+SE T +L +D I ++ VL Sbjct 1092 SSKRKSYLIATNRGISAYQFLSSKFYDLVSEGTTAKLMSKLDDIALSKLSASTVL 1146 >RecName: Full=Reverse gyrase 2; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Saccharolobus solfataricus P2] Sequence ID: Q97ZF5.1 Length: 1166 Range 1: 1 to 1146 Score:597 bits(1538), Expect:0.0, Method:Compositional matrix adjust., Identities:440/1206(36%), Positives:636/1206(52%), Gaps:164/1206(13%) Query 1 MIPIIYKEMCPNCFGEIYSSRLELGV-CERCLEEEERCSKLDLCRKLGDKKKL----DKL 55 MI ++YK CPNC G+I RL G+ CE CL +D K+ + DK+ Sbjct 1 MINVMYKNSCPNCGGDISGDRLLNGLPCEACLPYINGIDDVDHISKVKTLYNILLNNDKI 60 Query 56 KGYCKVWNEFKKFDR----FCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGL 111 K Y ++ F+ F + GYE S+QK+W +R+ N+SF++ APTG+GK+ + Sbjct 61 KNYWNLYYNITTFETVFKYFRDKTGYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTTTLM 120 Query 112 LMSLYLADRGKRCYIILPTTLLVKQTYERAQSLVGDNIKVVCYHSELSEREKRDIKKRIE 171 S+++ G+ I+PT L++Q +R + L +V C K D KK Sbjct 121 TYSVFI---GQDVVYIVPTKSLMEQVCKRLEKL---GAQVSC--------GKIDQKK--- 163 Query 172 EGDFQVLITTSNYLTRNMPPTTF---DFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDE 228 V + T +YL +N +F+ +DD DA++KS K DR + LLG +++ + Sbjct 164 -----VSVITISYLNKNADSIVSLKPNFVVIDDADAVIKSGKTTDRLVSLLGIPKDVYES 218 Query 229 AYKIILLMKWRKFDKAL--ELREKLRK---KLEGIKH--GCIVIASATGKSYGDKVKLYR 281 A ++I L F E++EK+R+ K+ K +VIASAT + G K K R Sbjct 219 AIQLIRLRNKYYFSNEYTEEVKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALR 278 Query 282 ELLNFEVGYGINKLRDVVDVYDEIDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLL 341 L FE R+++D Y E + L VK LG GGLI VS++YG +I+ + Sbjct 279 LLTGFEPSSIQLYARNIIDAYTE---NLDLSIVKELGSGGLILVSKEYGRSKLNEIKKYV 335 Query 342 RENNIKAKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKM 401 + AK+ S ++ +DF GK+D+L+G ASYYGV VRG+D P+R++Y I+YG+PK+ Sbjct 336 EDLGFNAKLAIS-GRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKI 394 Query 402 KFKLREYLEK----VRKNRKIDID-----------------------IEGKSL------- 427 + KL + L +R + I ID I+G+S+ Sbjct 395 RAKLFDALSNPFTLLRVGKLIGIDFSKLQNKILILNPSEVQLLKFSIIKGESINYHKLEQ 454 Query 428 -----------------EEIEDILKRDLKLRNFSIKVEDDEIYILIPDIKTYIQASGRTS 470 E++ED L D +F I ++ YI+ PD+ TY+Q SGR S Sbjct 455 LRQELLYYMSLVKDKLKEKVEDTLISD----SFVITKQNGNYYIVYPDMITYLQGSGRAS 510 Query 471 RMTEFGLTKGVSILLVDHWKLFESIEKYM--LFHYESEFKSAREVNFEELIKKIDEDREK 528 R+ GLT G SI+LVD +FE +EK M LF + F S N E+ K+++ R++ Sbjct 511 RLYNGGLTLGFSIILVDDRHIFEILEKKMQKLFP-NTTFTSLSNTNLSEIKIKLEDSRKE 569 Query 529 IKLCMRRGKVPDILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLI-- 586 +V + + L++VESP KA+TIA F RPS R + VYE I D N I Sbjct 570 -----EGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRIRNKVPVYETIIVDGNQIYV 624 Query 587 --ITASGGHIFDLVTKE-GYYGVKIEDNIYI-PIYMAIRKINGEQITDQKDIEEILRELI 642 I AS GHI DL ++ GYYG+K+ED+ I P Y I+K D +I Sbjct 625 LDIVASKGHIVDLTLEDIGYYGIKVEDDGTIKPYYDLIKKC--------LDCNKIFSSAS 676 Query 643 EKGESVKVINCRDNMETI---REIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIY 699 +K N + TI RE+A VD VFIA+D DTEGEKI YD+ + P+N N+Y Sbjct 677 DKCPYCGSANLQSAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVY 736 Query 700 RIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKN 759 R+ ++EIT++AIL A+ + K++ N V SQ+VRRIEDRWIGF LS L F + Sbjct 737 RVVYHEITKKAILEALRNPK-----KINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGH 791 Query 760 YLSAGRVQTPVLGWIIERYEEHKKKV--------------PYLSLKLEYDIYVGKIWEGD 805 AGRVQTPVLGWI+ + ++K + Y S K + + Y+ + Sbjct 792 NHGAGRVQTPVLGWIVNKTIKYKSAMGHVVYIDIAGYSIKKYFSEKRKVEEYINNLQVAR 851 Query 806 FKGEEVEVEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHR 865 E++ E L +SP PPFTTDTLL EA ++ L VM+IAQDLFE GL TYHR Sbjct 852 I--EKISEEKIL----LSPLPPFTTDTLLIEANMKYKLPANLVMKIAQDLFEAGLITYHR 905 Query 866 TSSTRVSLEGMKVAREYLKLSNL--EDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRE 923 T ST +S G+++A+EYL+ L E ++ E EG HE IRPT+ +D ELI+ I E Sbjct 906 TDSTHISSVGIEIAKEYLQKQALIKEFVPRSWESSEEGAHEAIRPTRAIDVNELIQEIEE 965 Query 924 N----NISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYI---KDIDERIEGYVDVEFD 976 N +I SK H+ +YDLIF+RFIASQM A I KD + +E + E Sbjct 966 NPYKYSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLIKLGKDDNVDVELLSNAE-G 1024 Query 977 GWTRIYNLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQI 1036 G+ ++Y +K+ LP + + + KV +I K + L +V+ LMK +GIGRPSTYA+ Sbjct 1025 GFIKVYPVKVYNLP-VGEIQPKV---NITKGSSEQLLSYSDVISLMKSKGIGRPSTYAKT 1080 Query 1037 IKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEV 1096 I+ L+ GY++ SK K LI T GI VY +L + + L+SE T L +D I ++ Sbjct 1081 IENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLVSESTTSRLMTKLDDIALSKL 1140 Query 1097 DYIQVL 1102 + VL Sbjct 1141 NASTVL 1146 >RecName: Full=Reverse gyrase 1; Includes: RecName: Full=Helicase; Includes: RecName: Full=Topoisomerase [Sulfurisphaera tokodaii str. 7] Sequence ID: Q971T7.1 Length: 1156 Range 1: 1 to 1142 Score:595 bits(1533), Expect:0.0, Method:Compositional matrix adjust., Identities:450/1192(38%), Positives:650/1192(54%), Gaps:130/1192(10%) Query 1 MIPIIYKEMCPNCFGEIYSSRLELGV-CERCLEEEERCSKLDLCRKLGDKKKLDKLKGYC 59 M+ + Y CPNC G I L GV C +CL R LD K LKGY Sbjct 1 MLKVYYTFGCPNCGGPIDDEHLLAGVPCSKCLPG--RVENLDYRVIYDLLVKNSTLKGYA 58 Query 60 KVWNEFKKFDR----FCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFGLLMSL 115 + + + + F+ F + +G E ++QK W KR+ K++SFS+ APTG+GK+ L+ SL Sbjct 59 EYFYDNETFEEIVRIFKRVIGNEPWNLQKYWIKRLAKSESFSLSAPTGLGKTTTLLVYSL 118 Query 116 YLADRGKRCYIILPTTLLVKQTYERAQSLVGDNIKVVCYHSELSEREKRDIKKR-IEEGD 174 + ++ ++PT L Q ER +++ KV C D+K+ I Sbjct 119 FFSNT---TLYVVPTNSLKDQICERLRNM---GAKVSC----------NDVKEEYINVAT 162 Query 175 F-QVLITTSNYLTRNMPPTTFDFIFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKII 233 F ++L NY++ + P + VDD D +LKS K + +LG S E+ A +I Sbjct 163 FNRILRHYDNYVS--LQP---KLVIVDDSDMILKSGKTTEVMAKILGISEEIFQYAISLI 217 Query 234 LLMKWRKFDKA-LELREK---LRKKLEGIKHGC-IVIASATGKSYGDKVKLYRELLNFEV 288 L + KF++ EL+ K L K+ K ++ASAT + G K + R L+ FE Sbjct 218 RLKRILKFNEDDKELKNKIVELEYKIGSWKPFVQFLVASATLRPKGIKQQALRTLIGFEP 277 Query 289 GYGINKLRDVVDVYDE-IDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLLRENNIK 347 LR++ D+Y + +D + +L+ K+ GGL+ VS++YG E +++ ++ + Sbjct 278 STIQTYLRNIADLYYQGVDIEAILD--KISDNGGLLLVSKEYGREKMLELKEIIEKRGYS 335 Query 348 AKVVHSKDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKMKFKLRE 407 + S ++ F GKID LIG ASYYGV VRGLD P+R++Y IFYGIPK++ L + Sbjct 336 TGLAIS-GRKFLNKFTEGKIDYLIGSASYYGVAVRGLDEPKRLKYVIFYGIPKIRLNLTD 394 Query 408 YLE------KVRKNRKIDI-DIEGKSL--------------------------------- 427 L K+ + ID+ DI K L Sbjct 395 ALNNPSLIVKIGELLNIDVKDIRRKLLFLSPPEFQILRYSLMKDEELSGKLKDIKVNLIN 454 Query 428 --EEIEDILKRD----LKLRNFSIKVEDDEIYILIPDIKTYIQASGRTSRMTEFGLTKGV 481 E+I D+LK D LK F + + + Y+ IPD TYIQASGR+SR+ GLT G+ Sbjct 455 IKEKIWDVLKSDNIKKLKADTFLVTENNGKYYVYIPDTVTYIQASGRSSRIISNGLTFGI 514 Query 482 SILLVDHWKLFESI-EKYMLFHYESEFKSAREVNFEELIKKIDEDREKIKLCMRRGKVPD 540 SI+LVD+ L + + +K FK+ EV+ EL RE + + K + Sbjct 515 SIVLVDNIDLLDILSQKLKKIIPNFMFKNINEVDIRELKSLAVSSRE---VSTSQKKKIN 571 Query 541 ILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYE--VCIGDINLI--ITASGGHIFD 596 I K+IL++VESP KA+TIA FGRPSRR++ GI VYE + + D LI I A+ GHI D Sbjct 572 I-KTILLIVESPTKAKTIARLFGRPSRREVHGIPVYETIILVNDEILITNIIATKGHITD 630 Query 597 LVTKE-GYYGVKIEDNIYIPIYMAIRKI--NGEQITDQKDIEEILRELIEKGESVKVINC 653 L T+ GYYGV++ +N + Y I K G+ T I SV + + Sbjct 631 LTTENIGYYGVEVGNNEFNAYYSPIYKCYNCGKTFT-------IKSNTCPYCGSVFISSS 683 Query 654 RDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILR 713 + +R+++ EVD ++IA+D D EGEKI YD+ + I P+N+NIYRI ++EITR IL Sbjct 684 EKVVSALRKLSTEVDEIYIASDPDQEGEKIAYDVAMLISPYNKNIYRIKYHEITRNGILN 743 Query 714 AVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGW 773 A+ +G K++ N VKSQ+VRRIEDRWIGF+LS L +F + +GRVQ PVL W Sbjct 744 AI--LNKG---KINMNLVKSQIVRRIEDRWIGFELSLALKSMFYERNHGSGRVQGPVLSW 798 Query 774 IIERYEEHKKKVPY-LSLKLEYDIYVGKIW----EGDFKGEEVEVEVNLYS--RDI-SPS 825 I+ER +E+KK + L +KL D + K + E + E++ +++NL S ++I +P Sbjct 799 IVERTKEYKKNYGWILYIKLG-DYAIKKFFRIKEEANKFIEKLNIKINLISERKEIQNPL 857 Query 826 PPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGMKVAREYLKL 885 PPFTTD+LL +A + + ++ VM+IAQDLFE GL TYHRT ST VS G+ +A+EYL+ Sbjct 858 PPFTTDSLLMDAYDKLGIGSQIVMKIAQDLFESGLITYHRTDSTHVSALGISIAKEYLES 917 Query 886 SNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRENN----ISLSKNHIKLYDLIFR 941 NL D R + EG HE IRPT MDT LI+ I +N I +K H+++YDLIFR Sbjct 918 KNLNDSFSGRSWGNEGTHEAIRPTSSMDTESLIKDIEDNPNKYFIKFTKYHLRIYDLIFR 977 Query 942 RFIASQMKEATVVYEELYIKDIDERIEGYVDVEFD-GWTRIYNLKLRKLPKIEKSKLKVL 1000 RFIASQMK A V Y + I E++E + + G++ IY LK + EK + Sbjct 978 RFIASQMKPAEVTYSKFEIFINGEKLEVELPTKISGGFSIIYPLKTYVVS--EKYSTYLT 1035 Query 1001 DYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKL 1060 SI +PL+ E++K MKE+ IGRPSTYA+ I L+ GYV++SK K LI T Sbjct 1036 KGSI-----IPLFTYAEIIKNMKEKEIGRPSTYAKTISALIRHGYVVESKRKALLIATNK 1090 Query 1061 GIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHALKSICDQI 1112 GI+ Y +L + LISE +T+ L + +DKI G+V+ VL L QI Sbjct 1091 GIKAYEFLSSCCSDLISENRTKLLLQKIDKIANGDVNVDYVLEDLHKEITQI 1142 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Thermotoga maritima MSB8] Sequence ID: P46799.1 Length: 633 Range 1: 9 to 524 Score:218 bits(555), Expect:5e-59, Method:Compositional matrix adjust., Identities:199/586(34%), Positives:285/586(48%), Gaps:108/586(18%) Query 547 MVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYGV 606 +VVESP KA+TI S G N YEV AS GHI DL + +GV Sbjct 9 IVVESPAKAKTIKSILG----------NEYEVF---------ASMGHIIDL--PKSKFGV 47 Query 607 KIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIADE 666 +E + + P + I+ ++ + E L++L +KGE Sbjct 48 DLEKD-FEPEFAVIK--------GKEKVVEKLKDLAKKGE-------------------- 78 Query 667 VDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELKL 726 + IA+D+D EGE I + I R RI F+EIT R I AV+ R ++ Sbjct 79 ---LLIASDMDREGEAIAWHIARVTNTLGRK-NRIVFSEITPRVIREAVKNPR-----EI 129 Query 727 DENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE------ 780 D KV++QL RRI DR +G+ LS LW FK N LSAGRVQ+ L + +R E Sbjct 130 DMKKVRAQLARRILDRIVGYSLSPVLWRNFKSN-LSAGRVQSATLKLVCDREREILRFVP 188 Query 781 ---HKKKVPYLSLKLEYDIYVGKIWEGDFKGE-----EVEVEVNLYS-RDISPSPPFTTD 831 H+ V + L E D+ K ++ + E E+ VE S + +P PF T Sbjct 189 KKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTS 248 Query 832 TLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTYHRTSSTRVSLEGMKVAREYL 883 TL +EA + S + M IAQ L+E + TY RT STRVS + AR + Sbjct 249 TLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLI 308 Query 884 KLSNLEDYLKNR------EFYMEGPHECIRPTKPMDTGELIEFIRENNISLSKNHIKLYD 937 E+Y+ ++ ++ HE IRPT T E E L+ + KLY+ Sbjct 309 TEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPE------EAGKYLNSDQKKLYE 362 Query 938 LIFRRFIASQMKEATVVYEE----LYIKDIDERIEGYVDVE-FDGWTRIYNLKLR--KLP 990 LI++RF+ASQMK + YEE L KD R +G V + FDG+ +++ + + P Sbjct 363 LIWKRFLASQMKPSQ--YEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFP 420 Query 991 KIEKSKLK--VLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIK 1048 E +K V+ ++ P Y EG +VK M+ GIGRPSTYA IK LL+RGY+ Sbjct 421 FEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYI-- 478 Query 1049 SKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERG 1094 K +G L PT +G V +YL Y ++S T E+E+ +D++E+G Sbjct 479 KKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQG 524 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Aquifex aeolicus VF5] Sequence ID: O66893.1 Length: 540 Range 1: 3 to 525 Score:214 bits(545), Expect:2e-58, Method:Compositional matrix adjust., Identities:190/598(32%), Positives:289/598(48%), Gaps:115/598(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L +VESP KA+TI F G+ ++ A+ GH+ DL KE G Sbjct 3 LFIVESPTKAKTIQKFLGK-------------------GFLVKATLGHVKDLPEKE--LG 41 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V LR L K + V + +E +++++ Sbjct 42 VD------------------------------LRTL--KAKYVYKRGKKKLVEQLKKLSR 69 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 V++ TD D EGE I Y + ++ N+NI R F EIT AI E+ R ++ Sbjct 70 RSSIVYLGTDPDREGEAIAYFLKKDLEKVNKNIKRAVFYEITPEAIR---ESIRNAGDVN 126 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--- 782 + N V +Q RRI DR IG+ +S LW+ FK LSAGRVQ+P L I+ER E + Sbjct 127 M--NLVYAQFARRILDRLIGYLISPILWKEFKNYKLSAGRVQSPALRLIVEREREIQNFK 184 Query 783 -KKVPYLSLKLE---------YD----------IYVGKIWEGDFKGEEVEVEVNLYSRDI 822 KK Y+ L YD I K+ +G F +V + Sbjct 185 VKKYYYVKALLRKGSEEFWAIYDYRYENPSDAKIIAKKLEKGYFSV----YKVEKKKEKV 240 Query 823 SPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGMKVAREY 882 SP PF T L EA +F S+E ++AQ+L+E G TY RT S R++ + K Y Sbjct 241 SPPKPFITSDLQSEANAKFGFSSERTQKLAQELYEKGYITYPRTDSYRMNEKKAKEFMNY 300 Query 883 LKLSNLEDYL-KNREF----YMEGPHECIRPTKPMDTGELIEFIRENNISLSKNHIKLYD 937 ++ ++Y+ + R F +G HECIRPT +RE I + LYD Sbjct 301 IEKKYGKEYVGRLRRFREKATAQGAHECIRPTS----------LRE-EIPEREELRLLYD 349 Query 938 LIFRRFIASQMKEATVVYEELYIKDIDERIEGYV-------DVEFDGWTRIYNLKL--RK 988 LIFRR IAS MKE + E++ ++ I ++ V + FDGW+R+Y ++ K Sbjct 350 LIFRRTIASLMKEMLLEREKVTVEAITPELKHPVYLVAKGLKIVFDGWSRVYPSEITEEK 409 Query 989 LPKI-EKSKLKVLDYSI--RKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGY 1045 LP++ E L ++ ++ RK P Y EG ++K +++ GIGRPSTYA I+K L +RGY Sbjct 410 LPELYEGDLLDLVKTTLEERKTQPPPRYTEGTLIKTLEKLGIGRPSTYATIVKTLKERGY 469 Query 1046 VIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLH 1103 V K L+PT++ +V +L+ +P L+ + T ++EE +D +E G++++ V++ Sbjct 470 V--EVKKKALVPTEIAFQVVEFLMERFPTLMDYKFTAQMEEKLDLVEEGKLNWKSVVY 525 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819] Sequence ID: Q9PLZ2.1 Length: 700 Range 1: 1 to 542 Score:213 bits(542), Expect:9e-57, Method:Compositional matrix adjust., Identities:188/614(31%), Positives:292/614(47%), Gaps:125/614(20%) Query 542 LKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKE 601 +K L++VESP KA+TI +F G+ YEV AS GHI DL + Sbjct 1 MKKNLIIVESPAKAKTIGNFLGKD----------YEV---------IASKGHIRDL--PK 39 Query 602 GYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIR 661 +G+KIED+ +IP Y +IT D +++EL K + K Sbjct 40 SSFGIKIEDDEFIPEY---------RITS--DHSALVKELKSKAKDAK------------ 76 Query 662 EIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRG 721 V++ATD D EGE I Y I I + RI F+EIT+ AI A++ R Sbjct 77 -------EVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPR-- 127 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEH 781 KL+ + V +Q RR+ DR +G+KLS L + ++ LSAGRVQ+ L I++R +E Sbjct 128 ---KLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRG-LSAGRVQSAALKIIVDREKEI 183 Query 782 KKKVPYLSLKLEYDIYVGKIWEGDFKGEEVEVEV-----------------------NLY 818 + VP LEY + I++ D E VE + +Y Sbjct 184 RAFVP-----LEY-FSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVY 237 Query 819 S--------RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTT 862 S R I+P PPF T TL + A+ R + ++ M IAQ L+E +G+ T Sbjct 238 SISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVIT 297 Query 863 YHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNREFY-------MEGPHECIRPTKPMDTG 915 Y RT S ++ E ++ AR++++ + +DYL ++ + HE IRPT T Sbjct 298 YMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTP 357 Query 916 ELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKD--IDERIEGYVDV 973 E+ L K+ +KLY LI+ RF+A QM A + +++K+ + +I G + Sbjct 358 EIAAKF------LDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGR-KI 410 Query 974 EFDGWTRIYN--LKLRKLPKI---EKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIG 1028 FDG+ ++Y K + LP + K++ L+ + Y E +VK ++ GIG Sbjct 411 LFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIG 470 Query 1029 RPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIM 1088 RPSTYA I L R YV + +K +LIP+ + V L ++ ++ + T LE + Sbjct 471 RPSTYAPTISILTSRDYV--TIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTL 528 Query 1089 DKIERGEVDYIQVL 1102 D+I + D+ + L Sbjct 529 DEIAEDKADWQETL 542 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus haemolyticus JCSC1435] Sequence ID: Q4L5V2.1 Length: 689 Range 1: 5 to 545 Score:209 bits(533), Expect:1e-55, Method:Compositional matrix adjust., Identities:186/609(31%), Positives:289/609(47%), Gaps:120/609(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V +EDN Y P Y+ IR KG VK +++ A Sbjct 44 VDVEDN-YEPKYITIRG---------------------KGPVVK---------DLKKYAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 + VF+A+D D EGE I + + + + R+ FNEIT+ A+ + + + RG E+ Sbjct 73 KAKNVFLASDPDREGEAIAWHLSKILELDDSKENRVVFNEITKDAVKESFK-HPRGIEMD 131 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKKKV 785 L V +Q RRI DR +G+ +S LW+ KK LSAGRVQ+ L +I+R E + Sbjct 132 L----VDAQQARRILDRLVGYNISPVLWKKVKKG-LSAGRVQSVALRLVIDRENEIRNFK 186 Query 786 P--YLSLKLEYDI-----------YVGKIWE-----------GDFKGEEVEV-EVNLYSR 820 P Y S++ E+ Y K ++ + G++ E+ VN + Sbjct 187 PEEYWSIEGEFRYKKSKFTAKFLHYKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEK 246 Query 821 DISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSSTRV 871 +P+ PFTT TL +EA ++ N + M +AQ L+E +GL TY RT STR+ Sbjct 247 TRNPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRI 306 Query 872 SLEGMKVAREYLKLSNLEDYLKNREFYM----EGPHECIRPTKPMDTGELIEFIRENNIS 927 S A++Y++ +DYL NR + HE IRPT + T E Sbjct 307 SQTAKDEAKQYIEDKYGKDYLSNRTAKGKQGDQDAHEAIRPTSTLRTP------YEMKAY 360 Query 928 LSKNHIKLYDLIFRRFIASQMKEATV--VYEELYIKDIDERIEGYVDVEFDGWTRIY--- 982 L+++ +LY LI+ RF+ASQM A + V ++ +I R G ++F G+ +Y Sbjct 361 LTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNNIKFRANGQT-IKFKGFMTLYVEA 419 Query 983 -----NLKLRKLPKIEKS---KLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYA 1034 N K KLP + K ++ + P Y E +VK ++E IGRPSTYA Sbjct 420 KDDKDNEKENKLPNLSKGDEVTATQIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYA 479 Query 1035 QIIKKLLDRGYV-IKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIER 1093 I + R YV ++SK + +PT+LG VY + ++P +I E T +E ++DKI Sbjct 480 PTIDTIQKRNYVKLESK---RFVPTELGEIVYEQVKDYFPEIIDVEFTVNMETLLDKIAE 536 Query 1094 GEVDYIQVL 1102 G++ + +V+ Sbjct 537 GDIGWRKVI 545 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus RF122] Sequence ID: Q2YXL8.2 Length: 689 Range 1: 5 to 550 Score:206 bits(525), Expect:1e-54, Method:Compositional matrix adjust., Identities:188/615(31%), Positives:288/615(46%), Gaps:122/615(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V EDN Y P Y+ IR KG VK +++ A Sbjct 44 VDTEDN-YEPKYITIRG---------------------KGPVVK---------ELKKHAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 + VF+A+D D EGE I + + + + R+ FNEIT+ A+ E+++ E++ Sbjct 73 KAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVK---ESFKNPREIE 129 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQT----------------- 768 + N V +Q RRI DR +G+ +S LW+ KK LSAGRVQ+ Sbjct 130 M--NLVDAQQARRILDRLVGYNISPVLWKKVKKG-LSAGRVQSVALRLVIDRENEIRNFK 186 Query 769 PVLGWIIE---RYEEHKKKVPYL-----SLKLEYDIYVGKIWEGDFKGEEVEV-EVNLYS 819 P WIIE RY++ K +L KL+ + KI G++ E+ V Sbjct 187 PEEYWIIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDIEKITAA-LDGDQFEITNVTKKE 245 Query 820 RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSSTR 870 + +P+ PFTT TL +EA ++ N + M +AQ L+E +GL TY RT STR Sbjct 246 KTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTR 305 Query 871 VSLEGMKVAREYLKLSNLEDYLKNREFYM----EGPHECIRPTKPMDTGELIEFIRENNI 926 +S A++Y+ E Y R+ + HE IRP+ M T + ++ Sbjct 306 ISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSF----- 360 Query 927 SLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK--DIDERIEGYVDVEFDGWTRIY-- 982 L+K+ +LY LI+ RF+ASQM A + L I DI R G ++F G+ +Y Sbjct 361 -LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT-IKFKGFMTLYVE 418 Query 983 ------NLKLRKLPKIE---KSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTY 1033 + K KLPK+E K ++ + P Y E +VK ++E IGRPSTY Sbjct 419 TKDDIDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY 478 Query 1034 AQIIKKLLDRGYV-IKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 A I + R YV ++SK + +PT+LG V+ + ++P +I E T +E ++DKI Sbjct 479 APTIDTIQKRNYVKLESK---RFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIA 535 Query 1093 RGEVDYIQVLHALKS 1107 G++ + +V+ S Sbjct 536 EGDITWRKVIDGFFS 550 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus epidermidis RP62A] Sequence ID: Q5HPU2.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus epidermidis ATCC 12228] Sequence ID: Q8CSU3.1 Length: 689 Range 1: 5 to 545 Score:206 bits(524), Expect:1e-54, Method:Compositional matrix adjust., Identities:191/614(31%), Positives:287/614(46%), Gaps:130/614(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIEKYLGKRYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V EDN Y P Y+ IR KG VK +++ A Sbjct 44 VDTEDN-YEPKYITIRG---------------------KGPVVK---------DLKKHAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 + +F+A+D D EGE I + + + + R+ FNEIT+ A+ + + + RG E+ Sbjct 73 KAKKIFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKDSFK-HPRGIEMD 131 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE----- 780 L V +Q RRI DR +G+ +S LW+ KK LSAGRVQ+ L +I+R E Sbjct 132 L----VDAQQARRILDRLVGYNISPVLWKKVKKG-LSAGRVQSVALRLVIDRENEIRNFK 186 Query 781 -----------------------HKKKVPYLSLKLEYDIYVGKIWEGDFKGEEVEV-EVN 816 H K PY KL V +I E G++ E+ VN Sbjct 187 PEEYWSIEGEFRYKKSKFTAKFLHYKNKPY---KLNNKDDVQRITEA-LNGDQFEITNVN 242 Query 817 LYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTS 867 + P+ PFTT TL +EA ++ N + M +AQ L+E +GL TY RT Sbjct 243 RKEKTRYPAHPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTD 302 Query 868 STRVSLEGMKVAREYLKLSNLEDYLKNREFYM----EGPHECIRPTKPMDTGELIEFIRE 923 STR+S A++Y+ E Y+ R+ + HE IRPT M T + ++ Sbjct 303 STRISTSAKSEAQQYINDKYGEQYVSQRKSSGKQGDQDAHEAIRPTSTMRTPDDMKAF-- 360 Query 924 NNISLSKNHIKLYDLIFRRFIASQMKEATV--VYEELYIKDIDERIEGYVDVEFDGWTRI 981 L+++ +LY LI+ RF+ASQM A + V ++ DI R G ++F G+ + Sbjct 361 ----LTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNDIKFRANGQT-IKFKGFMTL 415 Query 982 Y--------NLKLRKLPKIEKSKLKVLDYSIRKVNKV----PLYDEGEVVKLMKERGIGR 1029 Y N K KLP+++K KV I P Y E +VK ++E IGR Sbjct 416 YVEAKDDKENDKENKLPQLDKGD-KVTATKIEPAQHFTQPPPRYTEARLVKTLEELKIGR 474 Query 1030 PSTYAQIIKKLLDRGYV-IKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIM 1088 PSTYA I + R YV ++SK + IPT+LG VY + ++P +I E T +E ++ Sbjct 475 PSTYAPTIDTIQKRNYVKLESK---RFIPTELGEIVYEQVKEYFPEIIDVEFTVNMETLL 531 Query 1089 DKIERGEVDYIQVL 1102 DKI G++++ +V+ Sbjct 532 DKIAEGDMNWRKVI 545 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Fervidobacterium islandicum] Sequence ID: O34204.1 Length: 699 Range 1: 37 to 575 Score:206 bits(524), Expect:2e-54, Method:Compositional matrix adjust., Identities:190/623(30%), Positives:290/623(46%), Gaps:144/623(23%) Query 543 KSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEG 602 K +++VESP KA+TI G N Y+V +S GHI DL K+ Sbjct 37 KKKVIIVESPAKAKTIERILG----------NDYQVI---------SSKGHIRDLPQKQ- 76 Query 603 YYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIRE 662 +GV + K++ E I ++ + E ++++ E Sbjct 77 -FGVDLNS----------LKLDFEIIPGKESVVEQIKKMTSGKE---------------- 109 Query 663 IADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGE 722 V + +D D EGE I + + + +NI I F EIT RAI AV+ R Sbjct 110 -------VLLPSDQDREGEAIAWHLSTILGVKGKNI--ITFTEITERAIKEAVKNPR--- 157 Query 723 ELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK 782 ++D NKV +QL RR+ DR +G+ +S LW + K + SAGRVQ+ L I ER E Sbjct 158 --EIDMNKVNAQLARRVLDRIVGYMISPLLWRIIK-DARSAGRVQSAALKIICERERERY 214 Query 783 KKVPYLSLKLEYDI-----YVGKIWEGDFKGEEVEVEVNLYSRDI--------------- 822 + VP K+ DI Y+ K+ K ++ E+ S+D+ Sbjct 215 RFVPQKYFKVWIDIAGLKAYLTKVDGKKIKPTDITEEI---SKDVLQKVKSVRLVDIDVK 271 Query 823 ----SPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTYHRTSSTR 870 +P PF T TL ++A + + M+IAQ+L+E TY RT STR Sbjct 272 EVRKNPPAPFITSTLQQDAASKLGFPVSKTMKIAQELYEGVDTKEGHTAFITYMRTDSTR 331 Query 871 VSLEGMKVA---------REYLKLSN--LEDYLKNREFYMEGPHECIRPTKPMDTGELIE 919 VS + A REYL S+ + ++ HECIRP T E + Sbjct 332 VSDVAKEAAEKFILKNFGREYLNESSEVASKKGSKTKGKVQDAHECIRPVDVNITPEKAK 391 Query 920 FIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEE----------LYIKDIDERIEG 969 + L K+H KLY+LI++RFIASQM ++ +Y++ ++ I ERI Sbjct 392 EL------LDKDHHKLYELIWKRFIASQM--SSAIYKQYSYDFESGKYVFEASIRERI-- 441 Query 970 YVDVEFDGWTRIYNLKLRKLPKIEKSKLKV-----LDYSIRKVNKVPL--YDEGEVVKLM 1022 FDG+ ++Y + P + +LKV ++ + P Y E +VK + Sbjct 442 -----FDGFEKVYTID--NEPSEKHKELKVDQEYLVEPKSAEAQTTPPDRYTEASLVKTL 494 Query 1023 KERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTR 1082 + GIGRPSTYA II+ LLDRGYV+K + LIPT LG V +YL +P ++ + T Sbjct 495 EMEGIGRPSTYATIIQTLLDRGYVVKKRK--TLIPTILGFVVNHYLEQRFPDIVDKGFTA 552 Query 1083 ELEEIMDKIERGEVDYIQVLHAL 1105 E+E+ +D++E G+ D+ +V+ + Sbjct 553 EMEKELDEVENGKKDWKEVVKSF 575 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus MSSA476] Sequence ID: Q6G9W3.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus MRSA252] Sequence ID: Q6GHI5.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus N315] Sequence ID: Q7A5Y5.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus MW2] Sequence ID: Q8NWZ9.2 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus Mu50] Sequence ID: Q99UM1.1 Length: 689 Range 1: 5 to 550 Score:206 bits(523), Expect:2e-54, Method:Compositional matrix adjust., Identities:188/615(31%), Positives:287/615(46%), Gaps:122/615(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V EDN Y P Y+ IR KG VK +++ A Sbjct 44 VDTEDN-YEPKYITIRG---------------------KGPVVK---------ELKKHAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 + VF+A+D D EGE I + + + + R+ FNEIT+ A+ E+++ E++ Sbjct 73 KAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVK---ESFKNPREIE 129 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQT----------------- 768 + N V +Q RRI DR +G+ +S LW+ KK LSAGRVQ+ Sbjct 130 M--NLVDAQQARRILDRLVGYNISPVLWKKVKKG-LSAGRVQSVALRLVIDRENEIRNFK 186 Query 769 PVLGWIIE---RYEEHKKKVPYL-----SLKLEYDIYVGKIWEGDFKGEEVEV-EVNLYS 819 P W IE RY++ K +L KL+ V KI G++ E+ V Sbjct 187 PEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAA-LDGDQFEITNVTKKE 245 Query 820 RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSSTR 870 + +P+ PFTT TL +EA ++ N + M +AQ L+E +GL TY RT STR Sbjct 246 KTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTR 305 Query 871 VSLEGMKVAREYLKLSNLEDYLKNREFYM----EGPHECIRPTKPMDTGELIEFIRENNI 926 +S A++Y+ E Y R+ + HE IRP+ M T + ++ Sbjct 306 ISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSF----- 360 Query 927 SLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK--DIDERIEGYVDVEFDGWTRIY-- 982 L+K+ +LY LI+ RF+ASQM A + L I DI R G ++F G+ +Y Sbjct 361 -LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT-IKFKGFMTLYVE 418 Query 983 ------NLKLRKLPKIE---KSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTY 1033 + K KLPK+E K ++ + P Y E +VK ++E IGRPSTY Sbjct 419 TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY 478 Query 1034 AQIIKKLLDRGYV-IKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 A I + R YV ++SK + +PT+LG V+ + ++P +I E T +E ++DKI Sbjct 479 APTIDTIQKRNYVKLESK---RFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIA 535 Query 1093 RGEVDYIQVLHALKS 1107 G++ + +V+ S Sbjct 536 EGDITWRKVIDGFFS 550 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus] Sequence ID: Q06AK7.1 Length: 689 Range 1: 5 to 550 Score:206 bits(523), Expect:2e-54, Method:Compositional matrix adjust., Identities:188/615(31%), Positives:287/615(46%), Gaps:122/615(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V EDN Y P Y+ IR KG VK +++ A Sbjct 44 VDTEDN-YEPKYITIRG---------------------KGPVVK---------ELKKHAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 + VF+A+D D EGE I + + + + R+ FNEIT+ A+ E+++ E++ Sbjct 73 KAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVK---ESFKNPREIE 129 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQT----------------- 768 + N V +Q RRI DR +G+ +S LW+ KK LSAGRVQ+ Sbjct 130 M--NLVDAQQARRILDRLVGYNISPVLWKKVKKG-LSAGRVQSVALRLVIDRENEIRNFK 186 Query 769 PVLGWIIE---RYEEHKKKVPYL-----SLKLEYDIYVGKIWEGDFKGEEVEV-EVNLYS 819 P W IE RY++ K +L KL+ V KI G++ E+ V Sbjct 187 PEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITTA-LDGDQFEITNVTKKE 245 Query 820 RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSSTR 870 + +P+ PFTT TL +EA ++ N + M +AQ L+E +GL TY RT STR Sbjct 246 KTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTR 305 Query 871 VSLEGMKVAREYLKLSNLEDYLKNREFYM----EGPHECIRPTKPMDTGELIEFIRENNI 926 +S A++Y+ E Y R+ + HE IRP+ M T + ++ Sbjct 306 ISDTAKAEAKQYITNKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSF----- 360 Query 927 SLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK--DIDERIEGYVDVEFDGWTRIY-- 982 L+K+ +LY LI+ RF+ASQM A + L I DI R G ++F G+ +Y Sbjct 361 -LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT-IKFKGFMTLYVE 418 Query 983 ------NLKLRKLPKIE---KSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTY 1033 + K KLPK+E K ++ + P Y E +VK ++E IGRPSTY Sbjct 419 TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY 478 Query 1034 AQIIKKLLDRGYV-IKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 A I + R YV ++SK + +PT+LG V+ + ++P +I E T +E ++DKI Sbjct 479 APTIDTIQKRNYVKLESK---RFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIA 535 Query 1093 RGEVDYIQVLHALKS 1107 G++ + +V+ S Sbjct 536 EGDITWRKVIDGFFS 550 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus USA300] Sequence ID: Q2FHI8.2 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus NCTC 8325] Sequence ID: Q2FZ32.2 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus COL] Sequence ID: Q5HGI2.1 Length: 689 Range 1: 5 to 550 Score:204 bits(520), Expect:4e-54, Method:Compositional matrix adjust., Identities:188/615(31%), Positives:287/615(46%), Gaps:122/615(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V EDN Y P Y+ IR KG VK +++ A Sbjct 44 VDTEDN-YEPKYITIRG---------------------KGPVVK---------ELKKHAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 + VF+A+D D EGE I + + + + R+ FNEIT+ A+ E+++ E++ Sbjct 73 KAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVK---ESFKNPREIE 129 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQT----------------- 768 + N V +Q RRI DR +G+ +S LW+ KK LSAGRVQ+ Sbjct 130 M--NLVDAQQARRILDRLVGYNISPVLWKKVKKG-LSAGRVQSVALRLVIDRENEIRNFK 186 Query 769 PVLGWIIE---RYEEHKKKVPYL-----SLKLEYDIYVGKIWEGDFKGEEVEV-EVNLYS 819 P W IE RY++ K +L KL+ V KI G++ E+ V Sbjct 187 PEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAA-LDGDQFEITNVTKKE 245 Query 820 RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSSTR 870 + +P+ PFTT TL +EA ++ N + M +AQ L+E +GL TY RT STR Sbjct 246 KTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTR 305 Query 871 VSLEGMKVAREYLKLSNLEDYLKNREFYM----EGPHECIRPTKPMDTGELIEFIRENNI 926 +S A++Y+ E Y R+ + HE IRP+ M T + ++ Sbjct 306 ISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSF----- 360 Query 927 SLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK--DIDERIEGYVDVEFDGWTRIY-- 982 L+K+ +LY LI+ RF+ASQM A + L I DI R G ++F G+ +Y Sbjct 361 -LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT-IKFKGFMTLYVE 418 Query 983 ------NLKLRKLPKIE---KSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTY 1033 + K KLPK+E K ++ + P Y E +VK ++E IGRPSTY Sbjct 419 TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY 478 Query 1034 AQIIKKLLDRGYV-IKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 A I + R YV ++SK + +PT+LG V+ + ++P +I E T +E ++DKI Sbjct 479 APTIDTIQKRNYVKLESK---RFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIA 535 Query 1093 RGEVDYIQVLHALKS 1107 G++ + +V+ S Sbjct 536 EGDITWRKVIDGFFS 550 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292] Sequence ID: Q49X35.1 Length: 688 Range 1: 5 to 549 Score:204 bits(518), Expect:8e-54, Method:Compositional matrix adjust., Identities:190/616(31%), Positives:290/616(47%), Gaps:125/616(20%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V E N Y P Y+ IR KG VK +++ A Sbjct 44 VDAE-NDYEPKYITIRG---------------------KGPVVK---------ELKKHAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIG--LNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEE 723 + VF+A+D D EGE I + + LN+ N R+ FNEIT+ A+ + + + RG E Sbjct 73 KAKKVFLASDPDREGEAIAWHLANILNLEDSTEN--RVVFNEITKDAVKDSFK-HPRGIE 129 Query 724 LKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK- 782 ++L V +Q RRI DR +G+ +S LW+ KK LSAGRVQ+ L +I+R E + Sbjct 130 MEL----VDAQQARRILDRLVGYNISPVLWKKVKKG-LSAGRVQSVALRLVIDRENEIRN 184 Query 783 ---------------KKVPYLSLKLEYDIYVGKIWE--------GDFKGEEVEV-EVNLY 818 KK + + L + K+ E G++ EV +V Sbjct 185 FKPEEYWKIEGEFRYKKTKFTAKFLHFKNKPFKLTEKADVEKITTQLDGDQFEVTKVTKK 244 Query 819 SRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSST 869 + P+ PFTT TL +EA ++ N + M +AQ L+E +GL TY RT ST Sbjct 245 EKTRYPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKKQGTVGLITYMRTDST 304 Query 870 RVSLEGMKVAREYLKLSNLEDYLKNREFYMEG---PHECIRPTKPMDT-GELIEFIRENN 925 R+S + A+ Y++ + DY NR+ +G HE IRP+ + T E+ F Sbjct 305 RISDQAQSEAKNYIQETYGNDYTSNRKSKGQGDQDAHEAIRPSSTLRTPNEMKNF----- 359 Query 926 ISLSKNHIKLYDLIFRRFIASQMKEA--TVVYEELYIKDIDERIEGYVDVEFDGWTRIY- 982 L+++ +LY LI+ RF+ASQM A V +L DI R G ++F G+ +Y Sbjct 360 --LTRDQHRLYKLIWERFVASQMAPAILDTVAMDLTQNDIKFRANGQT-IKFKGFMTLYV 416 Query 983 -------NLKLRKLPKIEKSKLKV---LDYSIRKVNKVPLYDEGEVVKLMKERGIGRPST 1032 + K KLP I + ++ ++ S P Y E +VK M+E IGRPST Sbjct 417 ETKDDSEDGKDNKLPNIGEGEMVTATNIEPSQHFTQPPPRYTEARLVKTMEELKIGRPST 476 Query 1033 YAQIIKKLLDRGYVIKSKNKGK-LIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKI 1091 YA I + R YV KN+ K +PT+LG V+ + ++P +I + T +E ++DK+ Sbjct 477 YAPTIDTIQKRNYV---KNESKRFVPTELGEIVHEQVKDYFPEIIDVDFTVNMETLLDKV 533 Query 1092 ERGEVDYIQVLHALKS 1107 GE+ + +V+ S Sbjct 534 ADGEIGWKKVISDFYS 549 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Treponema pallidum subsp. pallidum str. Nichols] Sequence ID: O83409.1 Length: 731 Range 1: 19 to 554 Score:201 bits(512), Expect:9e-53, Method:Compositional matrix adjust., Identities:181/606(30%), Positives:289/606(47%), Gaps:123/606(20%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G ++ AS GH+ DL + Sbjct 19 LVIVESPAKAQTIEKYLG-------------------TQYVVRASMGHVIDL--PKSRLA 57 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 + IE + + P Y+ +R + L+EL R ++ Sbjct 58 IDIEHD-FQPEYITVR-----------GRAQCLKEL-------------------RTLSK 86 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPF-NRNIYRIGFNEITRRAILRAVEAYRRGEEL 724 + VF+A+D D EGE I Y + +I + + I RI FNEIT AI A+ G + Sbjct 87 QSLQVFLASDRDREGEAIAYHLAQSIQAYCDTPIKRIVFNEITPHAIRAAI-----GHPV 141 Query 725 KLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKKK 784 +D KV +Q RR+ DR +G+ L LW K N LSAGRVQ+ L I ER E K+ Sbjct 142 PIDTAKVNAQKARRVLDRLVGYHLCPLLWHKVK-NGLSAGRVQSVALRLICEREVEVKRF 200 Query 785 VP--YLSLKLEYD-----------IYVGK--IWE---------GDFKGEEVEV-EVNLYS 819 VP Y +++ ++ + GK +++ G F E V ++ + Sbjct 201 VPEEYWTVEGTFEKDKKSFSALLILIQGKKAVFKSKQEATSAIGLFSQSEARVSQIRSFE 260 Query 820 RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTYHRTSSTRV 871 +++ P PFTT TL + A R ++ + M++AQ L+E +GL TY RT S RV Sbjct 261 KNVRPKQPFTTSTLQQCAANRLGFTSRKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRV 320 Query 872 SLEGMKVAREYLKLSNLEDYLK---NREFYMEG----PHECIRPTKPMDTGELIEFIREN 924 S +K R ++ ++ D L NR + +G HE IRPT T E I+ Sbjct 321 SEAAVKEVRAWIA-THFSDALPGTPNR-YAAKGKSQDAHEAIRPTYVAHTPERIK----- 373 Query 925 NISLSKNHIKLYDLIFRRFIASQMKEATV---VYEELYIKDIDERIEGYVDVEFDGWTRI 981 L+++ I+LY LI+ RF+ASQM +A V +E + E V +E G+ R+ Sbjct 374 -AHLTRDQIRLYTLIWERFVASQMTDARVRSLTFEITAGPAVFSATETQV-IE-QGFYRV 430 Query 982 YNLKLRK------LPKIEKSKLKVLD--YSIRKVNKVPL-YDEGEVVKLMKERGIGRPST 1032 + K LP ++ ++ L S++ + P+ Y + +VK+++E+GIGRPST Sbjct 431 LKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKMLEEKGIGRPST 490 Query 1033 YAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 YA I LLDR YV + + +L+PT LG + + L T++ ++ T +E +D++E Sbjct 491 YAPTISVLLDRYYVTRIQK--QLMPTPLGKVISDLLTTYFHDVVDVSFTARMESKLDEVE 548 Query 1093 RGEVDY 1098 ++ + Sbjct 549 EDKIKW 554 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Halalkalibacterium halodurans C-125] Sequence ID: Q9KA23.1 Length: 690 Range 1: 5 to 547 Score:201 bits(510), Expect:1e-52, Method:Compositional matrix adjust., Identities:177/614(29%), Positives:292/614(47%), Gaps:128/614(20%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + AS GH+ DL + G Sbjct 5 LVIVESPAKAKTIGKYLGK-------------------KYTVKASMGHVRDLPKSQ--MG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V IED Y P Y+ IR +L+EL + A Sbjct 44 VDIEDE-YSPRYITIRGKG-----------PVLKEL-------------------KSAAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +V V++A D D EGE I + + ++ + R+ FNEIT++AI A ++ R Sbjct 73 KVKRVYLAADPDREGEAIAWHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPR-----P 127 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKKKV 785 ++ + V +Q RR+ DR +G+ +S LW+ KK LSAGRVQ+ + II+R +E + Sbjct 128 INMDLVDAQQARRVLDRLVGYNISPLLWKKVKKG-LSAGRVQSVAVKMIIDREKEIQAFE 186 Query 786 P--YLSLKLEYDIYVGKIWEGDF-----------------------KGEEVEVE-VNLYS 819 P Y S++ + + G+ +E F KG++ V+ V Sbjct 187 PEEYWSIQGTFAL-DGEPFEAKFYGTNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKE 245 Query 820 RDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSSTR 870 R +P PFTT +L +EA ++ N ++ M +AQ L+E +GL TY RT STR Sbjct 246 RKRNPVSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTR 305 Query 871 VSLEGMKVAREYLKLSNLEDYLKN------REFYMEGPHECIRPTK-PMDTGELIEFIRE 923 +S +EY++ ++Y +N ++ + HE IRPT D L E+ Sbjct 306 ISDTAKAETKEYIESKFGKEYAQNGTKAVKKDKKSQDAHEAIRPTSVERDPKSLKEY--- 362 Query 924 NNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDE----RIEGYVDVEFDGWT 979 LS++ ++LY LI+ R +ASQM A + + + + +E R G V+F G+ Sbjct 363 ----LSRDQLRLYKLIWERLVASQM--APAIMDTMTVDLSNEGVLFRATG-SKVKFPGFM 415 Query 980 RIY--------NLKLRKLPKIEKSKL---KVLDYSIRKVNKVPLYDEGEVVKLMKERGIG 1028 ++Y + R LP +++ + + ++ S P Y E +VK M+E GIG Sbjct 416 KVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELGIG 475 Query 1029 RPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIM 1088 RPSTYA + + RGYV + ++ + +PT+LG V + +P ++ E T ++E+ + Sbjct 476 RPSTYAPTLDTIQKRGYV--ALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDL 533 Query 1089 DKIERGEVDYIQVL 1102 D IE G+ +I+++ Sbjct 534 DSIEEGKQQWIKII 547 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Pasteurella multocida subsp. multocida str. Pm70] Sequence ID: Q9CN30.1 Length: 868 Range 1: 5 to 566 Score:201 bits(510), Expect:8e-52, Method:Compositional matrix adjust., Identities:172/605(28%), Positives:300/605(49%), Gaps:95/605(15%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G N ++ +S GHI DL T G Sbjct 5 LVIVESPAKAKTINKYLGS-------------------NYVVKSSVGHIRDLPTVGSSNG 45 Query 606 VKIEDNIYIPIYMAIRKINGEQ---ITDQKDIEEILREL-----IEKGESVKVINCRDNM 657 K + ++ + ++ E+ I +KD +++ + + + +++ ++ + Sbjct 46 EKAK-------AISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKV 98 Query 658 -ETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVE 716 ++ +A + D +++ATD+D EGE I + + I + R+ FNEIT+ AI +A E Sbjct 99 VAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFE 158 Query 717 AYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIE 776 + E+L LD +V +Q RR DR +GF +S LW+ + LSAGRVQ+ + ++E Sbjct 159 ---KPEQLNLD--RVNAQQTRRFLDRVVGFMVSPLLWKKVARG-LSAGRVQSVAVKLVVE 212 Query 777 RYEEHKKKVP--------------YLSLKLEYDIYVGKIWEGDFKGEEVEVEVNLYSR-- 820 R E K P +L+L + GK +E + + V+ Sbjct 213 REREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPK-NATQAQSAVDFLQHAD 271 Query 821 ----DISPSP-------PFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSST 869 D+ P PF T TL + A+ R ++ M +AQ L+E G TY RT ST Sbjct 272 YVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDST 331 Query 870 RVSLEGMKVAREYLKLSNLEDYLKNRE-FY-----MEGPHECIRPTKPMDTGELIEFIRE 923 +S + +K+ R Y++ E YL ++ FY + HE IRP+ D L E + Sbjct 332 NLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPS---DVNTLAEQL-- 386 Query 924 NNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK--DIDERIEGYVDVEFDGWTRI 981 + K+ ++LYDLI+R+F+A QM A + ++ + + + +G + + FDGWT++ Sbjct 387 --TGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRI-LRFDGWTKV 443 Query 982 Y-----NLKLRKLPKIEKSKLKVLDYSIRK--VNKVPL-YDEGEVVKLMKERGIGRPSTY 1033 N + + LP ++ ++ L++ + + K P + E +VK +++RGIGRPSTY Sbjct 444 LPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTY 503 Query 1034 AQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIER 1093 A II + +RGYV + +N+ + K+G V + L + L++ + T +E I+D+I Sbjct 504 AAIISTIQERGYV-RVENR-RFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIAN 561 Query 1094 GEVDY 1098 GE ++ Sbjct 562 GEKNW 566 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Haemophilus influenzae Rd KW20] Sequence ID: P43012.1 Length: 868 Range 1: 5 to 566 Score:196 bits(499), Expect:2e-50, Method:Compositional matrix adjust., Identities:173/604(29%), Positives:297/604(49%), Gaps:93/604(15%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G ++ +S GHI DL T G Sbjct 5 LVIVESPAKAKTINKYLGS-------------------QYVVKSSVGHIRDLPTVGSSTG 45 Query 606 VKIEDNIYIPIYMAIRKINGEQ---ITDQKDIEEILREL-----IEKGESVKVINCRDNM 657 K + PI + + ++ E+ I +K+ +++ + + + +++ ++ + Sbjct 46 EKAK-----PI--STKGMDAEEKAKIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKV 98 Query 658 ET-IREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVE 716 + ++ +A + D +++ATD+D EGE I + + I + R+ FNEIT+ AI +A E Sbjct 99 VSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNDDRFSRVVFNEITKNAIKQAFE 158 Query 717 AYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIE 776 + E+L +D +V +Q RR DR +GF +S LW+ + LSAGRVQ+ + ++E Sbjct 159 ---KPEQLNMD--RVNAQQTRRFLDRVVGFMVSPLLWKKVARG-LSAGRVQSVAVKLLVE 212 Query 777 RYEEHKKKVP--------------YLSLKLEYDIYVGKIWEG----------DFKGEEVE 812 R E K P +++L+ Y GK ++ DF Sbjct 213 REREIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSDY 272 Query 813 VEVNLYSRDIS--PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTR 870 V +L ++ S P PF T TL + A+ R ++ M +AQ L+E G TY RT ST Sbjct 273 VVTDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTN 332 Query 871 VSLEGMKVAREYLKLSNLEDYLKNR-EFY-----MEGPHECIRPTKPMDTGELIEFIREN 924 +S + + +AR Y++ YL + FY + HE IRP+ I + E+ Sbjct 333 LSQDALNMARTYIENHFGAQYLPEKPNFYSSKENAQEAHEAIRPSD-------IRALPES 385 Query 925 NISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK--DIDERIEGYVDVEFDGWTRIY 982 + K+ ++LYDLI+ +F+A QM A L + D + +G + + FDGWT++ Sbjct 386 LEGMEKDAVRLYDLIWCQFLACQMPPAQYDSSTLTVTAGDYTLKAKGRI-LRFDGWTKVL 444 Query 983 -----NLKLRKLPKI---EKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYA 1034 N + ++LP + EK LK + + + E +VK +++RGIGRPSTYA Sbjct 445 PQIGKNPEDQELPSVTVSEKLALKEVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYA 504 Query 1035 QIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERG 1094 II + +RGYV +++N+ + K+G V + L + L++ + T +E+ +DKI G Sbjct 505 AIISTIQERGYV-RTENR-RFYAEKMGEIVTDRLNESFGELMNYDFTANMEDTLDKIASG 562 Query 1095 EVDY 1098 V++ Sbjct 563 SVNW 566 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Pseudomonas aeruginosa PAO1] Sequence ID: Q9HZJ5.1 Length: 868 Range 1: 5 to 569 Score:195 bits(495), Expect:6e-50, Method:Compositional matrix adjust., Identities:177/606(29%), Positives:285/606(47%), Gaps:90/606(14%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVT------ 599 L++VESP KA+TI + G ++ +S GHI DL T Sbjct 5 LVIVESPAKAKTINKYLGS-------------------QYVVKSSIGHIRDLPTSGSSSS 45 Query 600 -KEGYYGVKI--EDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDN 656 + G K E P A R++ D + + E++ E V Sbjct 46 KEPAAKGRKSASEAPALSPKEKARRQLVSRMGVDPEHGWKAKYEILPGKEKV-------- 97 Query 657 METIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVE 716 ++ +R +A + D V++ATD+D EGE I + + I R+ FNEIT++AI E Sbjct 98 IDELRRLAKDADTVYLATDLDREGEAIAWHLREAIGGDESRYKRVVFNEITKKAIQ---E 154 Query 717 AYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIE 776 A+ + EL D N+V +Q RR DR +G+ +S LW+ + LSAGRVQ+ + ++E Sbjct 155 AFSQPGEL--DINRVNAQQARRFLDRVVGYMVSPLLWQKIARG-LSAGRVQSVAVKLVVE 211 Query 777 RYEEHKKKVPYLSLKLEYDIYVGKIWEGDF-----KGEEVE-------------VEVNLY 818 R E + VP ++ D+ K F KGE + ++ + Y Sbjct 212 REREIRAFVPEEYWEVHADLGTAKGANVRFEVTREKGEAFKPLNEAQAMAALEKLKASAY 271 Query 819 S------RDIS--PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTR 870 S R S PS PF T TL + A+ R ++ M +AQ L+E G TY RT ST Sbjct 272 SVAKREDRPTSSRPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 331 Query 871 VSLEGMKVAREYLKLSNLEDYLKNRE---FYMEGPHECIRPTKPMDTGELIEFIRENNIS 927 +S + + + R +++ + YL + EG E +P D ++ +S Sbjct 332 LSADAIGMVRGFIEDEFGQKYLPGKANVYSSKEGAQEAHEAIRPSDVN-----LKPTQLS 386 Query 928 -LSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK--DIDERIEGYVDVEFDGWTRIYNL 984 + ++ +LYDLI+R+F+A QM A + + + D + R +G + ++FDG+TR+ Sbjct 387 GMERDAERLYDLIWRQFVACQMTPAEYLSTSVSVTAGDFELRAKGRI-LKFDGYTRVLPQ 445 Query 985 KLRK-----LPKI---EKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQI 1036 + + LP++ E KL LD S Y E +VK +++RGIGRPSTYA I Sbjct 446 QSKPGEDDVLPEMKEGENLKLIKLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAI 505 Query 1037 IKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEV 1096 I + +RGYV + + + K+G V + L + +L+ T +EE +D + +GE Sbjct 506 ISTIQERGYV--TTHNRRFYAEKMGDIVTDRLNESFANLMDYGFTAGMEEHLDDVAQGER 563 Query 1097 DYIQVL 1102 D+ +L Sbjct 564 DWKHLL 569 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Lactococcus lactis subsp. lactis Il1403] Sequence ID: Q9CG80.1 Length: 710 Range 1: 28 to 563 Score:192 bits(488), Expect:9e-50, Method:Compositional matrix adjust., Identities:181/613(30%), Positives:287/613(46%), Gaps:133/613(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + GR N + AS GHI DL K+ Sbjct 28 LVIVESPAKAKTIEKYLGR-------------------NYKVVASVGHIRDL--KKSTMS 66 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V IE N Y P Y+ IR +IN ++++ A Sbjct 67 VDIE-NDYEPQYINIRG------------------------KAPLIN------SLKKEAK 95 Query 666 EVDGVFIATDIDTEGEKIGYDIG--LNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEE 723 V++A+D D EGE I + + LN+ +N R+ FNEIT+ A+ A + R+ Sbjct 96 AAKAVYLASDPDREGEAISWHLAHILNLPLEEKN--RVVFNEITKDAVKNAFKEPRQ--- 150 Query 724 LKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKK 783 +D + V +Q RR+ DR +G+ +S LW+ KK LSAGRVQ+ L I++R E Sbjct 151 --IDVDLVDAQQARRVLDRLVGYSISPILWKKVKKG-LSAGRVQSIALKLIVDRENEINA 207 Query 784 KVP--YLSLKLEYDI----YVGKIWEGDFK------------------GEEVEVE-VNLY 818 +P Y S+ E+ + W D K G + V+ V Sbjct 208 FIPEEYWSIDGEFKKGTKKFKASFWGIDGKKHPLKTNEDVIKVMERLDGPDFNVDKVEKK 267 Query 819 SRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRTSST 869 R + P+TT ++ ++A + N T + M +AQ L+E GL TY RT ST Sbjct 268 ERRRNAPLPYTTSSMQQDAANKLNFRTRKTMMVAQQLYEGLTLGSQGHQGLITYMRTDST 327 Query 870 RVSLEGMKVAREYLKLSNLEDYLKN-----REFYMEGPHECIRPTKPMDTGELIEFIREN 924 R+S A Y+ E Y K+ + HE IRP+ +T + I Sbjct 328 RISPVAQSAAHNYIADQFGEKYSKHGSKVKNASGAQDAHEAIRPSNVFNTPDAIAKY--- 384 Query 925 NISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDER----IEGYVDVEFDGWTR 980 L K+ +KLY LI+ RF+ASQM A +++ + + ++ + I V+FDG+ R Sbjct 385 ---LDKDQLKLYTLIWNRFVASQMVAA--IFDTVKV-NLSQNGVIFIANGSQVKFDGYLR 438 Query 981 IYNL--KLRKLPKIEKSKLKVLDYSIRKVNKVP---------LYDEGEVVKLMKERGIGR 1029 IYN K LP++E+++ +++K N P Y E ++K ++E G+GR Sbjct 439 IYNDSDKSNMLPEMEENE------TVKKANVKPEQHFTQPPARYSEATLIKTLEENGVGR 492 Query 1030 PSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMD 1089 PSTYA ++ + R YV S + PT+LG V ++ +P++++ E T E+E+ +D Sbjct 493 PSTYAPTLETIQKRYYVRLSAK--RFEPTELGEIVNKLIVEFFPNIVNTEFTAEMEKDLD 550 Query 1090 KIERGEVDYIQVL 1102 ++E G+ +I+V+ Sbjct 551 EVEEGKRQWIEVV 563 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Synechococcus elongatus PCC 7942 = FACHB-805] Sequence ID: P34185.2 Length: 883 Range 1: 4 to 572 Score:194 bits(493), Expect:1e-49, Method:Compositional matrix adjust., Identities:184/636(29%), Positives:285/636(44%), Gaps:146/636(22%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVT------ 599 L++VESP KARTI ++ + R + AS GH+ DL Sbjct 4 LVIVESPTKARTIRNYLPKDYR-------------------VEASMGHVRDLPQSASDIP 44 Query 600 ------KEGYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINC 653 K GV +E+N + P+Y+ + D+K I Sbjct 45 TELKGEKWSNLGVDVENN-FAPLYIVPK--------DKKKI------------------- 76 Query 654 RDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILR 713 ++T+++ + D + +ATD D EGE I + + L +L R+ F+EIT+ AI Sbjct 77 ---VKTLKDALKDADELILATDEDREGESISWHL-LQLLQPRVPTKRMVFHEITQEAIQA 132 Query 714 AVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGW 773 A++ R +D+ V +Q RRI DR +G+ LS LW+ LSAGRVQ+ + Sbjct 133 ALKNCR-----DVDQRLVHAQETRRILDRLVGYTLSPLLWKKIAWG-LSAGRVQSVAVRL 186 Query 774 IIERYEEHK--KKVPYLSLKLEYDIYVG----KIWE---------GDF--------KGEE 810 +++R + ++ Y LK + + G K+W DF G + Sbjct 187 LVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQRLATGNDFDESTGQIIAGRQ 246 Query 811 V------EVEV-------------NLYSRDIS--PSPPFTTDTLLEEATKRFNLSTEEVM 849 V E E +L + + P+PPFTT TL +E+ ++ LS E M Sbjct 247 VCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAPPFTTSTLQQESNRKLRLSARETM 306 Query 850 RIAQDLFELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYL--KNREFYMEG-----P 902 R+AQ L+E G TY RT S +S + ++ AR ++ ++YL + R+F + Sbjct 307 RVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQPRQFTTKSKNAQEA 366 Query 903 HECIRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEA--TVVYEELYI 960 HE IRP G +E LS LYDLI++R IASQM EA T++ L + Sbjct 367 HEAIRP-----AGNTFRLPQETG--LSGAEFALYDLIWKRTIASQMAEARQTMLSVLLEV 419 Query 961 KDIDERIEGYVDVEFDGWTRIY---------NLKLRK--LPKI---EKSKLKVLDYSIRK 1006 + + R G ++F G+ R Y L+ R+ LP + ++ + L + Sbjct 420 DNAEFRASGK-RIDFPGFFRAYVEGSDDPDAALEDREILLPALKVGDRPTCQELAAIGHE 478 Query 1007 VNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYN 1066 Y E +VK+++ GIGRPSTYA II ++DRGY N L PT V Sbjct 479 TQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSN--TLTPTFTAFAVTA 536 Query 1067 YLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVL 1102 L H+P L+ + +E+ +D I GEVD++ L Sbjct 537 LLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYL 572 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Xylella fastidiosa Temecula1] Sequence ID: Q87AQ6.1 Length: 815 Range 1: 5 to 562 Score:189 bits(479), Expect:3e-48, Method:Compositional matrix adjust., Identities:177/625(28%), Positives:281/625(44%), Gaps:135/625(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DLV KEG Sbjct 5 LLIVESPAKAKTINKYLGK-------------------DFTVLASYGHVRDLVPKEG--- 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 A+ NG + +LI+K E ++E I + A Sbjct 43 -------------AVDPENGFAMR---------YDLIDKNEK--------HVEAITKAAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNI----LPFNRNIYRIGFNEITRRAILRAVEAYRRG 721 D +++ATD D EGE I + I + L ++ + RI F EIT RAI A++ R Sbjct 73 TADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRM- 131 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE- 780 + + V +Q RR D +GF LS LW ++ LSAGRVQ+P L I+ER EE Sbjct 132 ----IASDLVDAQQARRALDYLVGFNLSPVLWRKVQRG-LSAGRVQSPALRMIVEREEEI 186 Query 781 -----------HKK---KVPYLSLKL---------EYDIYVGKIWEGDFKGEEVEVEVNL 817 H + + S KL ++ I + + + L Sbjct 187 EAFITREYWSIHAECTHPAQHFSAKLIKLDGKKFEQFTITDSDTAAAAQRRIQQAAQGRL 246 Query 818 YSRDIS-------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLT 861 + D++ P+PPF T TL +EA+++ +T + M+IAQ L+E +GL Sbjct 247 HITDVTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLI 306 Query 862 TYHRTSSTRVSLEGMK-----VAREY--LKLSNLEDYLKNREFYMEGPHECIRPTKPMDT 914 TY RT S +SL+ + +AR+Y L + + + + HE +RPT + T Sbjct 307 TYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRT 366 Query 915 GELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERI--EGYVD 972 + LS +LY+L+++R +ASQM A + + + +E + Sbjct 367 PTQVAPY------LSNEEHRLYELVWKRTVASQMIPAILNTTSVDLAAGNEHVFRATGTT 420 Query 973 VEFDGWTRIY-----------NLKLRKLPKIEKSKLKVLDYSIRK---VNKVPLYDEGEV 1018 V G+ +Y + + RKLP ++ + L+ + + P Y E + Sbjct 421 VVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPPRYTEAAL 480 Query 1019 VKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLI-PTKLGIEVYNYLITHYPHLIS 1077 VK ++E GIGRPSTYA II+ LL R YV +G+ PT +G V +L +H+ + Sbjct 481 VKALEEYGIGRPSTYASIIQTLLFRKYV---DMEGRSFRPTDIGRAVSKFLSSHFTQYVD 537 Query 1078 EEKTRELEEIMDKIERGEVDYIQVL 1102 + T LE+ +D I RGE ++I ++ Sbjct 538 YDFTAHLEDELDAISRGEEEWIPLM 562 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P39814.1 Length: 691 Range 1: 1 to 547 Score:187 bits(474), Expect:4e-48, Method:Compositional matrix adjust., Identities:178/616(29%), Positives:284/616(46%), Gaps:124/616(20%) Query 542 LKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKE 601 + L++VESP KA+TI + G+ + + AS GH+ DL + Sbjct 1 MSDYLVIVESPAKAKTIERYLGKKYK-------------------VKASMGHVRDLPKSQ 41 Query 602 GYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIR 661 GV IE N + P Y+ IR +L+EL + K + Sbjct 42 --MGVDIEQN-FEPKYITIRGKG-----------PVLKELKTAAKKAKKVY--------- 78 Query 662 EIADEVDGVFIATDIDTEGEKIGYDIGLNI-LPFNRNIYRIGFNEITRRAILRAVEAYRR 720 +A D D EGE I + + ++ L N + R+ FNEIT+ AI E+++ Sbjct 79 ----------LAADPDREGEAIAWHLAHSLDLDLNSDC-RVVFNEITKDAI---KESFKH 124 Query 721 GEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE 780 + +D V +Q RRI DR +G+K+S LW+ KK LSAGRVQ+ L II+R +E Sbjct 125 PRMINMD--LVDAQQARRILDRLVGYKISPILWKKVKKG-LSAGRVQSVALRLIIDREKE 181 Query 781 HKKKVPYLSLKLEYDIYVGK-IWEGDF-----------------------KGEEVEVE-V 815 P ++ G+ +E F KG + VE V Sbjct 182 INDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPLNSEADVKEILSQLKGNQYTVEKV 241 Query 816 NLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLTTYHRT 866 R +P+ PFTT TL +EA ++ N ++ M IAQ L+E +GL TY RT Sbjct 242 TKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRT 301 Query 867 SSTRVSLEGMKVAREYLKLSNLEDYL------KNREFYMEGPHECIRPTKPMDTGELIEF 920 STR+S + A ++ + +++L + + HE IRPT ++ Sbjct 302 DSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPAKKNENAQDAHEAIRPT------SVLRK 355 Query 921 IRENNISLSKNHIKLYDLIFRRFIASQMKEATV--VYEELYIKDIDERIEGYVDVEFDGW 978 E L ++ ++LY LI+ RF+ASQM A + + +L + R G V+F G+ Sbjct 356 PSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMSVDLTNNGLTFRANG-SKVKFSGF 414 Query 979 TRIY--------NLKLRKLPKIEKSKLKVLDYSIRK----VNKVPLYDEGEVVKLMKERG 1026 ++Y K R LP +++ VL I P Y E +VK ++ERG Sbjct 415 MKVYVEGKDDQMEEKDRMLPDLQEGDT-VLSKDIEPEQHFTQPPPRYTEARLVKTLEERG 473 Query 1027 IGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEE 1086 IGRPSTYA + + RGYV + + + +PT+LG V + ++ +P +I+ E T ++E Sbjct 474 IGRPSTYAPTLDTIQRRGYV--ALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMER 531 Query 1087 IMDKIERGEVDYIQVL 1102 +D +E G ++++++ Sbjct 532 DLDHVEEGNTEWVKII 547 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Xylella fastidiosa 9a5c] Sequence ID: Q9PEV8.1 Length: 815 Range 1: 5 to 562 Score:188 bits(477), Expect:7e-48, Method:Compositional matrix adjust., Identities:177/625(28%), Positives:281/625(44%), Gaps:135/625(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + + AS GH+ DLV KEG Sbjct 5 LLIVESPAKAKTINKYLGK-------------------DFTVLASYGHVRDLVPKEG--- 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 A+ NG + +LI+K E ++E I + A Sbjct 43 -------------AVDPENGFAMR---------YDLIDKNEK--------HVEAITKAAK 72 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNI----LPFNRNIYRIGFNEITRRAILRAVEAYRRG 721 D +++ATD D EGE I + I + L ++ + RI F EIT RAI A++ R Sbjct 73 TADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRM- 131 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE- 780 + + V +Q RR D +GF LS LW ++ LSAGRVQ+P L I+ER EE Sbjct 132 ----IASDLVDAQQARRALDYLVGFNLSPVLWRKVQRG-LSAGRVQSPALRMIVEREEEI 186 Query 781 -----------HKK---KVPYLSLKL---------EYDIYVGKIWEGDFKGEEVEVEVNL 817 H + + S KL ++ I + + + L Sbjct 187 EAFITREYWSIHAECAHPAQHFSAKLIKLDGQKFEQFTITDSDTAAAAQRRIQQVAQGRL 246 Query 818 YSRDIS-------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE---------LGLT 861 + D++ P+PPF T TL +EA+++ +T + M+IAQ L+E +GL Sbjct 247 HITDVTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLI 306 Query 862 TYHRTSSTRVSLEGMK-----VAREY--LKLSNLEDYLKNREFYMEGPHECIRPTKPMDT 914 TY RT S +SL+ + +AR+Y L + + + + HE +RPT + T Sbjct 307 TYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRT 366 Query 915 GELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERI--EGYVD 972 + LS +LY+L+++R +ASQM A + + + +E + Sbjct 367 PTQVAPY------LSNEEHRLYELVWKRAVASQMIPAILNTTSVDLAAGNEHVFRATGTT 420 Query 973 VEFDGWTRIY-----------NLKLRKLPKIEKSKLKVLDYSIRK---VNKVPLYDEGEV 1018 V G+ +Y + + RKLP ++ + L+ + + P Y E + Sbjct 421 VVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPPRYTEAAL 480 Query 1019 VKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLI-PTKLGIEVYNYLITHYPHLIS 1077 VK ++E GIGRPSTYA II+ LL R YV +G+ PT +G V +L +H+ + Sbjct 481 VKALEEYGIGRPSTYASIIQTLLFRKYV---DMEGRSFRPTDIGRAVSKFLASHFTRYVD 537 Query 1078 EEKTRELEEIMDKIERGEVDYIQVL 1102 + T LE+ +D I RGE ++I ++ Sbjct 538 YDFTAHLEDELDAISRGEEEWIPLM 562 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Synechocystis sp. PCC 6803 substr. Kazusa] Sequence ID: P73810.1 Length: 898 Range 1: 2 to 575 Score:188 bits(477), Expect:1e-47, Method:Compositional matrix adjust., Identities:182/642(28%), Positives:285/642(44%), Gaps:148/642(23%) Query 544 SILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKE-- 601 S L++VESP KARTI ++ + R + AS GH+ DL Sbjct 2 SKLVIVESPTKARTIRNYLPQDYR-------------------VEASMGHVRDLPASAEE 42 Query 602 ----------GYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVI 651 GV +ED+ + P+Y+ K +++++EL Sbjct 43 VPAAYKDKSWANLGVNVEDH-FSPLYVI-----------PKSKKKVVKEL---------- 80 Query 652 NCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAI 711 +T + ADEV +ATD D EGE I + + L +L I R+ F+EIT+ AI Sbjct 81 ------QTALKNADEV---ILATDEDREGESISWHL-LQLLQPKVPIKRMVFHEITQEAI 130 Query 712 LRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVL 771 A+E R +DEN V +Q RRI DR +G+ LS LW+ LSAGRVQ+ + Sbjct 131 RSALENCR-----DIDENLVHAQETRRILDRLVGYTLSPLLWKKIAWG-LSAGRVQSVAV 184 Query 772 GWIIERYEEHK--KKVPYLSLKLEYD----------IYVG--KIWEG-DF---------- 806 I++R + K Y LK E + + +G K+ G DF Sbjct 185 RLIVQRERARRAFKTAGYWDLKAELEQNKNPFQAKLMTLGGTKLANGSDFDPNTGALLPD 244 Query 807 -------KGEEVEVEVNLYSRDIS------------PSPPFTTDTLLEEATKRFNLSTEE 847 + + + ++ L + + PSPPFTT TL +EA ++ +S + Sbjct 245 KQVVVLDEAQAIALKERLTGKPWAVVNTEEKPGVRKPSPPFTTSTLQQEANRKLGISARD 304 Query 848 VMRIAQDLFELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYLK-------NREFYME 900 MR+AQ L+E G TY RT S +S + + AR ++ ++YL + + Sbjct 305 TMRVAQKLYEEGYITYMRTDSVHLSDQAVTAARNCVQQMYGKEYLSPQPKQYTTKSKGAQ 364 Query 901 GPHECIRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYI 960 HE IRP EF N L + LY+LI++R +A QM +A + + + Sbjct 365 EAHEAIRPAG-------TEFRIPNQTGLKDRELALYELIWKRTVACQMADARITQLSVLL 417 Query 961 K--DIDERIEGYVDVEFDGWTRIY-------NLKLRK----LPKI---EKSKLKVLDYSI 1004 K D + R G ++F G+ R Y + L LP + ++ + +D Sbjct 418 KVEDAEFRAAGK-RIDFPGYFRAYVEGSDDPDAALENQEVILPPLKVGDRPNCREIDTVG 476 Query 1005 RKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYV-IKSKNKGKLIPTKLGIE 1063 + Y E +VK ++ G+GRPSTYA II ++DRGYV ++SK L PT Sbjct 477 HETQPPARYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYVQMRSK---ALTPTFTAFA 533 Query 1064 VYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHAL 1105 V + L +H+P L+ T +E+ +D+I G+ ++ L Sbjct 534 VVSLLESHFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGF 575 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Helicobacter pylori 26695] Sequence ID: P55991.1 Length: 736 Range 1: 4 to 541 Score:186 bits(473), Expect:1e-47, Method:Compositional matrix adjust., Identities:180/607(30%), Positives:289/607(47%), Gaps:119/607(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI +F D N + AS GH+ DL + G Sbjct 4 LIIVESPAKAKTIKNFL-------------------DKNYEVIASKGHVRDL--SKFALG 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 +KI++ + P Y+ KD +E+++++IE + + Sbjct 43 IKIDETGFTPNYVV-----------DKDHKELVKQIIELSKKASI--------------- 76 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +IATD D EGE IGY + I + RI F+EIT+ AIL A++ R K Sbjct 77 ----TYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPR-----K 127 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--K 783 +D +KV +Q RR DR +GFKLS + K LSAGRVQ+ L +I++ E K K Sbjct 128 IDMSKVNAQQARRFLDRIVGFKLSSLIASKITKG-LSAGRVQSAALKLVIDKEREIKAFK 186 Query 784 KVPYLSLKLEYDIYVGK---IWEGD-FKGEEV-----------EVEVNLYS-------RD 821 + Y +L ++ ++ ++G+ K +E+ E+E Y+ Sbjct 187 PLTYFTLDAYFESHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYAISSIVKKSK 246 Query 822 ISPS-PPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTYHRTSSTRVS 872 SP+ PPF T TL + A+ S + M IAQ L+E +G+ TY RT S ++ Sbjct 247 KSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIA 306 Query 873 LEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRENNISLSKNH 932 E ++ AR + L+DY K+ Y+ P + +K + E E IR +I L N Sbjct 307 KEALEEARNKI----LKDYGKD---YLP-PKAKVYSSKNKNAQEAHEAIRPTSIILEPNA 358 Query 933 IK---------LYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVD---VEFDGWTR 980 +K LY LI++RF+ASQM++A ++E + E+ E + FDG+ + Sbjct 359 LKDYLKPEELRLYTLIYKRFLASQMQDA--LFESQSVVVACEKGEFKASGRKLLFDGYYK 416 Query 981 IY--NLKLRKLPKIEKS---KLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQ 1035 I + K + LP ++++ KL+ L+ + Y E ++K+++ GIGRPSTYA Sbjct 417 ILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAP 476 Query 1036 IIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGE 1095 I L +R Y+ K ++ + +V L H+ ++ + + LEE +D I + + Sbjct 477 TISLLQNRDYI--KVEKKQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNK 534 Query 1096 VDYIQVL 1102 DY QVL Sbjct 535 ADYQQVL 541 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Escherichia coli K-12] Sequence ID: P06612.2 Length: 865 Range 1: 1 to 575 Score:187 bits(474), Expect:2e-47, Method:Compositional matrix adjust., Identities:172/620(28%), Positives:293/620(47%), Gaps:94/620(15%) Query 542 LKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKE 601 + L++VESP KA+TI + G + ++ +S GHI DL T Sbjct 1 MGKALVIVESPAKAKTINKYLGS-------------------DYVVKSSVGHIRDLPTS- 40 Query 602 GYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIE-----EILRELIEKGESVKVINCRDN 656 G K D+ +K + ++ ++ E E++ E V Sbjct 41 GSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKV-------- 92 Query 657 METIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVE 716 + ++++A++ D +++ATD+D EGE I + + I + R+ FNEIT+ AI + Sbjct 93 VSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIR---Q 149 Query 717 AYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIE 776 A+ + EL +D +V +Q RR DR +G+ +S LW+ + LSAGRVQ+ + ++E Sbjct 150 AFNKPGELNID--RVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVE 206 Query 777 RYEEHKKKVPYLSLKLEYD----------IYVGKIWEGDFKG---EEVEVEVNLYSR--- 820 R E K VP +++ + V + F+ E+ + V+L + Sbjct 207 REREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY 266 Query 821 ----------DISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTR 870 P PF T TL + A+ R ++ M +AQ L+E G TY RT ST Sbjct 267 SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 326 Query 871 VSLEGMKVAREYLKLSNLEDYLK-------NREFYMEGPHECIRPTKPMDTGELIEFIRE 923 +S + + + R Y+ + + YL ++E E HE IRP+ D + E +++ Sbjct 327 LSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEA-HEAIRPS---DVNVMAESLKD 382 Query 924 NNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDV-EFDGWTRIY 982 + + KLY LI+R+F+A QM A L + D R++ + FDGWT++ Sbjct 383 ----MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM 438 Query 983 NLKLRK------LPKIEKS-KLKVLDYS-IRKVNKVPL-YDEGEVVKLMKERGIGRPSTY 1033 LRK LP + K L +++ + + K P + E +VK +++RGIGRPSTY Sbjct 439 PA-LRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTY 497 Query 1034 AQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIER 1093 A II + DRGYV + +N+ + K+G V + L ++ L++ + T ++E +D++ Sbjct 498 ASIISTIQDRGYV-RVENR-RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 Query 1094 GEVDYIQVL-HALKSICDQI 1112 E ++ VL H Q+ Sbjct 556 HEAEWKAVLDHFFSDFTQQL 575 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Sequence ID: P0A2I1.1 Length: 865 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Salmonella enterica subsp. enterica serovar Typhi] Sequence ID: P0A2I2.1 Length: 865 Range 1: 1 to 564 Score:185 bits(470), Expect:6e-47, Method:Compositional matrix adjust., Identities:166/608(27%), Positives:286/608(47%), Gaps:91/608(14%) Query 542 LKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKE 601 + L++VESP KA+TI + G + ++ +S GHI DL T Sbjct 1 MGKALVIVESPAKAKTINKYLGN-------------------DYVVKSSVGHIRDLPTS- 40 Query 602 GYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIE-----EILRELIEKGESVKVINCRDN 656 G K D+ +K + ++ ++ + E++ E V Sbjct 41 GSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKV-------- 92 Query 657 METIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVE 716 + ++++A++ D +++ATD+D EGE I + + I + R+ FNEIT+ AI +A E Sbjct 93 VSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFE 152 Query 717 AYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIE 776 + GE L+ N+V +Q RR DR +G+ +S LW+ + LSAGRVQ+ + ++E Sbjct 153 --QPGE---LNINRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVE 206 Query 777 RYEEHKKKVPYLSLKLEYDIYVGK--------IWEGDFKGEEVEVEVNLYSRDI------ 822 R E K VP +++ + + D V E L + + Sbjct 207 REREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARY 266 Query 823 ------------SPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTR 870 P PF T TL + A+ R ++ M +AQ L+E G TY RT ST Sbjct 267 SVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 326 Query 871 VSLEGMKVAREYLK-------LSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRE 923 +S + + + R Y+ L + + ++E E HE IRP+ D + E +++ Sbjct 327 LSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEA-HEAIRPS---DVAVMAESLKD 382 Query 924 NNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDV-EFDGWTRIY 982 + + KLY LI+R+F+A QM A L + + R++ + FDGWT++ Sbjct 383 ----MEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVM 438 Query 983 NL-----KLRKLPKIEKS-KLKVLDYS-IRKVNKVPL-YDEGEVVKLMKERGIGRPSTYA 1034 + R LP + K L +L+ + + K P + E +VK +++RGIGRPSTYA Sbjct 439 PALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYA 498 Query 1035 QIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERG 1094 II + DRGYV + +N+ + K+G V + L ++ L++ + T ++E+ +D++ Sbjct 499 SIISTIQDRGYV-RVENR-RFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANH 556 Query 1095 EVDYIQVL 1102 + ++ VL Sbjct 557 QAEWKAVL 564 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Vibrio cholerae O1 biovar El Tor str. N16961] Sequence ID: Q9KRB2.1 Length: 876 Range 1: 5 to 571 Score:185 bits(469), Expect:8e-47, Method:Compositional matrix adjust., Identities:169/603(28%), Positives:282/603(46%), Gaps:82/603(13%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G+ + I+ +S GH+ DL T G Sbjct 5 LVIVESPAKAKTINKYLGK-------------------DFIVKSSVGHVRDLPTA-GQTA 44 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKG-----ESVKVINCRDNM-ET 659 + EQ +K+ +++++ + +++ ++ + Sbjct 45 TPTGKAAAA-STKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAE 103 Query 660 IREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYR 719 ++++A + D V++ATD+D EGE I + + I + R+ FNEIT+ AI +A++ Sbjct 104 LQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQ---QAFK 160 Query 720 RGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYE 779 + EL +D V +Q RR DR +GF +S LW+ + LSAGRVQ+ + ++ER Sbjct 161 QPGELNMD--GVNAQQARRFMDRVVGFMVSPLLWKKVARG-LSAGRVQSVAVKLLVERER 217 Query 780 EHKKKVP----------YLSLKLEYDIYVGKIWEGDFKG-EEVEVEVNLYSRDIS----- 823 E K VP + K ++ + V + FK E E + + + + Sbjct 218 EIKAFVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVC 277 Query 824 ----------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSL 873 PS PF T TL + A+ R ++ M +AQ L+E G TY RT ST +S Sbjct 278 KREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSA 337 Query 874 EGMKVAREYLKLSNLEDYLKNR------EFYMEGPHECIRPTKPMDTGELIEFIRENNIS 927 E ++ R Y+ E YL ++ + + HE IRP+ T + +E Sbjct 338 EAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVTADDLE-------G 390 Query 928 LSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDV-EFDGWTRIYNLKL 986 + + KLY LI+ +F+A QM A + +K + ++ + +FDGWTR+ Sbjct 391 MEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLG 450 Query 987 RK----LPKI---EKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKK 1039 + LP + + KL LD Y E +VK +++RGIGRPSTYA II Sbjct 451 KNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIIST 510 Query 1040 LLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYI 1099 + DRGYV ++ + K+G V + L ++ L++ + T +EE +D+I GEV++ Sbjct 511 IQDRGYV--KVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWT 568 Query 1100 QVL 1102 VL Sbjct 569 AVL 571 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821] Sequence ID: Q9X3X7.3 Length: 1212 Range 1: 3 to 548 Score:186 bits(473), Expect:9e-47, Method:Compositional matrix adjust., Identities:174/618(28%), Positives:274/618(44%), Gaps:130/618(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L+VVESP KA+TI + G + Y+V AS GHI DL +K+G Sbjct 3 LVVVESPAKAKTIEKYLG----------SGYQVL---------ASYGHIRDLPSKDG--- 40 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 ++ NG + Q ++ R ++ I + Sbjct 41 -------------SVNPDNGFSMVWQNYPDKAHR-----------------LKAIEDAVK 70 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNR---NIYRIGFNEITRRAILRAVEAYRRGE 722 E D + +ATD D EGE I + I + ++ R+ FN IT+ A+ A+ R Sbjct 71 ESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPR--- 127 Query 723 ELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK 782 +LD + + + L RR D +GF LS LW SAGRVQ+ L +++R +E + Sbjct 128 --QLDNDLINAYLARRALDYLVGFTLSPILWRKLP-GAKSAGRVQSVALRLVVDREQEIE 184 Query 783 KKVPYLSLKLEYDIYVGKI--------WEGD----------FKGEEVEVEV--------N 816 P +E D+ I W G + E + +V N Sbjct 185 GFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSN 244 Query 817 LYSRDIS--PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLE 874 + ++ +S P PPFTT TL +EA ++ + MR+AQ L+E GL TY RT ++ Sbjct 245 VETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDES 304 Query 875 GMKVAREYLKLSNLEDYL--KNREFYMEG-----PHECIRPTKPMDTGELIEFIRENNIS 927 + AR+ + Y+ K R++ ++ HE IRPT +F R+ + Sbjct 305 AIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPT---------DFSRDK--A 353 Query 928 LSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDE----RIEGYVDVEFDGWTRIY- 982 S +H +LY+LI++R +ASQM A + + + D R+ G V V F G+ +Y Sbjct 354 ASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQV-VLFSGFLTLYE 412 Query 983 -------NLKLRKLPKIEKSKLKVLDYSIRK--------VNKVPLYDEGEVVKLMKERGI 1027 N + K + L+ D ++K P Y E +VK M++ GI Sbjct 413 ESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGI 472 Query 1028 GRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEI 1087 GRPSTYA +I+ L DR YV +N + IP++ G + +L + +S + T LE+ Sbjct 473 GRPSTYASVIQVLKDRAYVTLERN--RFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDS 530 Query 1088 MDKIERGEVDYIQVLHAL 1105 +D+I G D+ +VL A Sbjct 531 LDEISGGRADWQKVLDAF 548 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Helicobacter pylori J99] Sequence ID: Q9ZMV7.1 Length: 736 Range 1: 4 to 541 Score:181 bits(460), Expect:4e-46, Method:Compositional matrix adjust., Identities:179/607(29%), Positives:287/607(47%), Gaps:119/607(19%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI +F D N + AS GH+ DL + G Sbjct 4 LIIVESPAKAKTIKNFL-------------------DKNYEVVASKGHVRDL--SKFALG 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 +KI++ + P Y+ KD +E+++++IE + + Sbjct 43 IKIDETGFTPNYVV-----------DKDHKELVKQIIELSKKASI--------------- 76 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +IATD D EGE IGY + I + RI F+EIT+ AIL ++ R K Sbjct 77 ----TYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNVLKTPR-----K 127 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--K 783 +D KV +Q RR+ DR +GFKLS + K LSAGRVQ+ L +I+R +E + K Sbjct 128 IDMFKVNAQQARRLLDRIVGFKLSSLIASKITKG-LSAGRVQSAALKLVIDREKEIRPFK 186 Query 784 KVPYLSLKLEYDIYVGK---IWEGD-FKGEEV-----------EVEVNLY-------SRD 821 + Y +L ++ ++ ++G+ K +E+ E+E Y Sbjct 187 PLTYFTLDALFEPHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYIISSIIKKSK 246 Query 822 ISPS-PPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTYHRTSSTRVS 872 SP+ PPF T TL + A+ S + M IAQ L+E +G+ TY RT S ++ Sbjct 247 KSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIA 306 Query 873 LEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRENNISLSKN- 931 E ++ AR + L+DY K+ Y+ P + +K + E E IR +I L N Sbjct 307 KEALEEARAKI----LKDYGKD---YLP-PKAKVYSSKNKNAQEAHEAIRPTSIILEPNA 358 Query 932 --------HIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVD---VEFDGWTR 980 +KLY LI++RF+ASQM++A ++E + E+ E + FDG + Sbjct 359 LKDYLKPEELKLYTLIYKRFLASQMQDA--LFESQSVVVACEKGEFKASGRKLLFDGHYK 416 Query 981 IY--NLKLRKLPKIEKS---KLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQ 1035 I + K + LP ++++ KL+ L+ + Y E ++K+++ GIGRPSTYA Sbjct 417 ILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAP 476 Query 1036 IIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGE 1095 I L +R Y+ K ++ + +V L H+ ++ + + LEE +D I + + Sbjct 477 TISLLQNRDYI--KVEKKQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNK 534 Query 1096 VDYIQVL 1102 DY QVL Sbjct 535 ADYQQVL 541 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia conorii str. Malish 7] Sequence ID: Q92IH1.1 Length: 776 Range 1: 3 to 573 Score:177 bits(449), Expect:1e-44, Method:Compositional matrix adjust., Identities:183/640(29%), Positives:287/640(44%), Gaps:143/640(22%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G + + AS GHI DL +K+G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKGSV- 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 + E + DI + + G+ V I +D A Sbjct 43 -----------------LPDENFAMKYDISD------KAGKYVDAI-VKD--------AK 70 Query 666 EVDGVFIATDIDTEGEKIGYDIG-----LNILPFNRNIYRIGFNEITRRAILRAVEAYRR 720 + D V++ATD D EGE I + + N + + R+ FNEIT++AI+ AVE R Sbjct 71 KADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPR- 129 Query 721 GEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE 780 KLD N V +Q RR D +GF LS LW SAGRVQ+ L I ER +E Sbjct 130 ----KLDTNLVNAQQARRALDYLVGFTLSPLLWRKLP-GCKSAGRVQSVALRLICEREDE 184 Query 781 HK--KKVPY--LSLKLEY---DIYVGKIWE-GDFKGEEVEVEVNLYSRDIS--------- 823 + K Y +SLK++ +++ K+ D K E+ + ++D++ Sbjct 185 IERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSHKFH 244 Query 824 ------------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTY 863 P PPF T +L +EA ++ S ++ M+IAQ L+E +GL TY Sbjct 245 VDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITY 304 Query 864 HRTSSTRVSLEGMKVAREYLKLSNLEDYL-------KNREFYMEGPHECIRPTKPMDTGE 916 RT +S + + R+ + S + YL K++ + HE IRPT T + Sbjct 305 MRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPD 364 Query 917 LIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYV----- 971 ++ L K++ KLY+LI++R IA QM+ V +L + ++ + Y+ Sbjct 365 SLK------EKLDKDYYKLYELIWKRTIACQMEN---VIMDLVVANLASENKEYLAKANG 415 Query 972 -DVEFDGWTRIY-----------NLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGEVV 1019 + FDG+ ++Y N L L + E K K + + P Y E +V Sbjct 416 STIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKAVIPNQHFTEPPPRYSEASLV 475 Query 1020 KLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEE 1079 K ++E GIGRPSTYA I+ L DR YV + K + IP +LG V +L+ + + + Sbjct 476 KKLEELGIGRPSTYASILSVLQDRKYV--ALEKKRFIPEELGRLVTVFLVGFFKKYVEYD 533 Query 1080 KTRELEEIMDKIERGEVDYIQVL--------HALKSICDQ 1111 T LE +D I G++++ L H ++S+ +Q Sbjct 534 FTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQ 573 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia bellii RML369-C] Sequence ID: Q1RIM1.1 Length: 800 Range 1: 3 to 573 Score:175 bits(443), Expect:1e-43, Method:Compositional matrix adjust., Identities:189/645(29%), Positives:286/645(44%), Gaps:153/645(23%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G + + AS GHI DL +K+G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKGSV- 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 I E + + DI E + G+ V I I++ A Sbjct 43 -----------------IPDENFSMKYDISE------KAGKYVDAI--------IKD-AK 70 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNR-----NIYRIGFNEITRRAILRAVEAYRR 720 + + V++ATD D EGE I + I I N+ R+ FNEIT++AI A+E R Sbjct 71 KAESVYLATDPDREGESISWHIAEVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPR- 129 Query 721 GEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE 780 KLD N V +Q RR D +GF LS LW SAGRVQ+ L I ER +E Sbjct 130 ----KLDNNLVNAQQARRALDYLVGFTLSPLLWRKLP-GCKSAGRVQSVALRLICEREDE 184 Query 781 HK--KKVPY--LSLKL---EYDIYVGKIWE-GDFKGEEVEVEVNLYSRDIS--------- 823 + K Y +SLK+ +++ K+ D K E+ + + ++D++ Sbjct 185 IERFKSEEYWDISLKMLNSNNELFTAKLTHINDQKLEKFSITNDKEAKDLTEKLKSQNFH 244 Query 824 ------------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTY 863 P PPF T +L +EA ++ S ++ M+IAQ L+E +GL TY Sbjct 245 VDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITY 304 Query 864 HRTSSTRVSLEGMKVAREYLKLSNLEDYL-------KNREFYMEGPHECIRPTK----PM 912 RT +S + + R+ + + YL K++ + HE IRPT P Sbjct 305 MRTDGVTLSNDAVDEIRKLINKDYGDKYLPSSPRIYKSKVKNAQEAHEAIRPTNINYIPN 364 Query 913 DTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKE-------ATVVYEELYIKDIDE 965 D E +E K++ KLY+LI++R IA QM+ AT+ E K+ Sbjct 365 DLKEKLE----------KDYYKLYELIWKRTIACQMENVIMDLVNATLASEN---KEYLA 411 Query 966 RIEGYVDVEFDGWTRIY-----------NLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYD 1014 R G + FDG+ ++Y N L L + E K K + + P Y Sbjct 412 RANGST-IAFDGFYKVYRESIDDEAEEENKMLPPLKEQEHLKTKEIIPNQHFTEPPPRYS 470 Query 1015 EGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPH 1074 E +VK ++E GIGRPSTYA I+ L DR YV + K + IP +LG V +L+ + Sbjct 471 EASLVKKLEELGIGRPSTYATILSVLQDRKYV--TLEKKRFIPEELGRLVTVFLVGFFKK 528 Query 1075 LISEEKTRELEEIMDKIERGEVDYIQVL--------HALKSICDQ 1111 + + T LE +D+I G++++ L H ++S+ Q Sbjct 529 YVEYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNKQ 573 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia felis URRWXCal2] Sequence ID: Q4UM42.1 Length: 776 Range 1: 3 to 573 Score:174 bits(440), Expect:2e-43, Method:Compositional matrix adjust., Identities:184/640(29%), Positives:286/640(44%), Gaps:143/640(22%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G + + AS GHI DL +K+G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKGSV- 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 + E + DI + + G+ V I +D A Sbjct 43 -----------------LPDENFAMKYDISD------KAGKYVDAI-VKD--------AK 70 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNR-----NIYRIGFNEITRRAILRAVEAYRR 720 + D V++ATD D EGE I + + I N+ R+ FNEIT++AI+ AVE R Sbjct 71 KADAVYLATDPDREGEAISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPR- 129 Query 721 GEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE 780 KLD N V +Q RR D +GF LS LW SAGRVQ+ L I ER +E Sbjct 130 ----KLDANLVNAQQARRALDYLVGFTLSPLLWRKLP-GCKSAGRVQSVALRLICEREDE 184 Query 781 HK--KKVPY--LSLKLEY---DIYVGKIWE-GDFKGEEVEVEVNLYSRDIS--------- 823 + K Y +SLK++ +++ K+ D K E+ + ++D++ Sbjct 185 IERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKDAKDLTEKLKSQNFH 244 Query 824 ------------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTY 863 P PPF T +L +EA ++ S ++ M+IAQ L+E +GL TY Sbjct 245 VDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITY 304 Query 864 HRTSSTRVSLEGMKVAREYLKLSNLEDYLKNRE-FY------MEGPHECIRPTKPMDTGE 916 RT +S + + R+ + + + YL N Y + HE IRPT T + Sbjct 305 MRTDGVTLSNDAIADIRKLIDKNYGDKYLPNSPRIYKSKVKNAQEAHEAIRPTNITYTPD 364 Query 917 LIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYV----- 971 ++ L K++ KLY+LI++R IA QM+ V +L + + + Y+ Sbjct 365 SLK------EKLEKDYYKLYELIWKRTIACQMEN---VIMDLVVASLASENKEYLAKANG 415 Query 972 -DVEFDGWTRIY-----------NLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGEVV 1019 + FDG+ ++Y N L L + E K K + + P Y E +V Sbjct 416 STIAFDGFYKVYRESVDDEAEEENKMLPPLKEQEPLKTKEIIPNQHFTEPPPRYSEASLV 475 Query 1020 KLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEE 1079 K ++E GIGRPSTYA I+ L DR YV S K + +P +LG V +L+ + + + Sbjct 476 KKLEELGIGRPSTYASILSVLQDRKYV--SLEKKRFMPEELGRLVTVFLVGFFKKYVEYD 533 Query 1080 KTRELEEIMDKIERGEVDYIQVL--------HALKSICDQ 1111 T LE +D+I G++++ L H ++S+ +Q Sbjct 534 FTAGLENELDEIAAGKLEWKAALNNFWSGFNHNIESVNEQ 573 >RecName: Full=DNA topoisomerase 1 type prokaryotic [Acanthamoeba polyphaga mimivirus] Sequence ID: Q5UQB5.1 Length: 854 Range 1: 2 to 613 Score:173 bits(439), Expect:4e-43, Method:Compositional matrix adjust., Identities:186/683(27%), Positives:297/683(43%), Gaps:185/683(27%) Query 544 SILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGY 603 SIL+++ESP K I+S G+ N ++ AS GH DL K+ Sbjct 2 SILILLESPGKISKISSILGK-------------------NYVVKASMGHFRDLDPKK-- 40 Query 604 YGVKIE-DNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIRE 662 + I+ DN + P+Y ++ K + VK N + M+ I Sbjct 41 --MSIDFDNDFEPVY-----------------------IVTKPDVVK--NLKSAMKNI-- 71 Query 663 IADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGE 722 D V++A D D EGE I + + P N R+ FN IT+ AI+ A++ G+ Sbjct 72 -----DLVYLAADEDREGEAIAQSLYDVLKP--SNYKRLRFNAITKDAIMSAIK--NAGD 122 Query 723 ELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK 782 +D+N V +Q RR+ DR G+ +S L LSAGRVQ+ + II++ E K Sbjct 123 ---IDKNLVDAQKARRVLDRLFGYLISPILQRQIGGK-LSAGRVQSVTVRIIIDKENEIK 178 Query 783 KKV------PYLSLKLEYDIYVGKIWEGD----------FKGEEVEVE-----------V 815 + Y + ++ + E + +KG+ ++ V Sbjct 179 NFINKNADSSYFKVSGTFNGAKATLHESNDKKPFDLETAYKGKTAQIALINSENPNSKVV 238 Query 816 NLYSRDI----------------SPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG 859 N R + SP+PPFTT TL +EA ++F +S + M+ AQ L+E G Sbjct 239 NFMKRCLKSQFFIHSVEDKMTTRSPAPPFTTSTLQQEANRKFGMSIDSTMKTAQKLYEGG 298 Query 860 LTTYHRTSSTRVSLEGMKVAREYLKLSNLEDY-----LKNREFYMEGPHECIRPTKPMDT 914 TY RT S +S EG + ++ + DY KN+ + HE IRPT P Sbjct 299 YITYMRTDSVEISAEGHRDIKKIITDQYGADYYQKNLYKNKAANSQEAHEAIRPTHP--- 355 Query 915 GELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYI---KDIDERIEGYV 971 EL+ E I IKLY LI++R IASQMK A + + I K +++++ + Sbjct 356 -ELLTL--EGEIE-DAYQIKLYKLIWQRTIASQMKPAKIKVTIIQISISKYVEDKLNPFY 411 Query 972 -------DVEFDGWTRIYNLKLR--------------KLPKIEKSKLKVLDYSIRK--VN 1008 V F G+ ++Y + K+P + SK+ + + R+ + Sbjct 412 YFQSQIETVVFPGFMKVYVESIDDPDTDNQITKNFTGKIPTV-GSKVTMEEIIARQEYMR 470 Query 1009 KVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYV----------------IKSKNK 1052 P Y E +VK ++E GIGRPSTY IK +++R YV IKS+NK Sbjct 471 PPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINREYVKITDVPGIKKDITIYSIKSENK 530 Query 1053 -------------------GKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIER 1093 K++PT LGI V ++L+ ++P + + T +E +D + Sbjct 531 KHIMEVYEDTDTILLGKENKKIVPTNLGITVNDFLMKYFPEFLDYKFTANMETDLDYVST 590 Query 1094 GEVDYIQVLH----ALKSICDQI 1112 G +++ ++ LK I D++ Sbjct 591 GTKNWVDIVQDFYDKLKPIVDEL 613 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Pyrococcus abyssi GE5] Sequence ID: Q9UYS8.1 Length: 685 Range 1: 2 to 567 Score:170 bits(431), Expect:1e-42, Method:Compositional matrix adjust., Identities:181/619(29%), Positives:269/619(43%), Gaps:110/619(17%) Query 545 ILMVVESPNKARTIASFFG--RPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEG 602 IL++ E PN AR IA RP R+ I G+ YEV LI+ ++ GH++ L K+ Sbjct 2 ILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQD 61 Query 603 YYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIRE 662 ++G I D ++P+Y+A KD +D ++ + Sbjct 62 FFGYPIFDIEWVPVYIA---------EKNKDY------------------AKDYIKALSV 94 Query 663 IADEVDGVFIATDIDTEGEKIGYDI---GLNILPFNRNIYRIGFNEITRRAILRAVEAYR 719 +A V +A D DTEGE IGY + P R+ F+ +T+R +L A Sbjct 95 LAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAK--RMKFSALTKRDLLNAW---- 148 Query 720 RGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKN-----YLSAGRVQTPVLGWI 774 R E ++ + + R + D + G LS L K+ LS GRVQ P L ++ Sbjct 149 RNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFL 208 Query 775 IERYEEHKKKVP--YLSLKL-------------EYDIYVGKIWEGD-----------FKG 808 +ER E + VP Y +KL E D KIW + K Sbjct 209 VEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKD----KIWSEEEAKKIVTEVKKSKA 264 Query 809 EEVEVEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSS 868 +EV R+ P PF TL EA F S ++ + IAQ L+E G T+Y RT S Sbjct 265 RVSNIEVKRQKRN--PPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTES 322 Query 869 TRV-----------SLEGMKVAREYLKLSNLEDYLKNREFYMEGP-HECIRPTKPMDTGE 916 ++ ++ M R Y L LK E E P H I PT GE Sbjct 323 QKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPT-----GE 377 Query 917 LIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDER--IEGYVDVE 974 + LSK+ KLYD+I RRF+A M+ A ++ I + + G V+ Sbjct 378 I-----PGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVK 432 Query 975 FDGWTRIYNLKLR----KLPKI---EKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGI 1027 GW +Y ++ LP+ E+ ++ + +K Y V+K M++ GI Sbjct 433 -QGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGI 491 Query 1028 GRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEI 1087 G +T AQI++ L RGY I+ K K+ P LG++V L + P +IS E TRE E Sbjct 492 GTKATRAQILETLYQRGY-IEGKKSIKVTP--LGMKVIETLEKYVPEIISVELTREFERK 548 Query 1088 MDKIERGEVDYIQVLHALK 1106 MD I +G++ +V+ K Sbjct 549 MDLIMQGKLTKEEVIEEAK 567 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Pyrococcus horikoshii OT3] Sequence ID: O58356.1 Length: 686 Range 1: 2 to 567 Score:168 bits(425), Expect:6e-42, Method:Compositional matrix adjust., Identities:178/614(29%), Positives:274/614(44%), Gaps:100/614(16%) Query 545 ILMVVESPNKARTIASFFG--RPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEG 602 IL++ E PN AR IA RP ++ + G+ YE+ LI+ ++ GH++ L K Sbjct 2 ILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKRD 61 Query 603 YYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIRE 662 +G I D ++P+Y+A EKG+ R+ ++ + Sbjct 62 VFGYPIFDIEWVPVYIA-----------------------EKGKEY----AREYIKALSV 94 Query 663 IADEVDGVFIATDIDTEGEKIGYDI---GLNILPFNRNIYRIGFNEITRRAILRAVEAYR 719 +A V +A D DTEGE IGY + P R R+ F+ +T+R +L A Sbjct 95 LAKRVREFIVACDYDTEGEVIGYTALKYACGVDP--RVAKRMKFSALTKRDLLNAW---- 148 Query 720 RGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKN-----YLSAGRVQTPVLGWI 774 R E ++ + + R I D + G LS L KK LS GRVQ P L ++ Sbjct 149 RNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFL 208 Query 775 IERYEEHKKKVP--YLSLKLEY---------DIYVGKIWEGDFKGEEVEVEVNLYSRDIS 823 +ER E + VP Y +KL + + KIWE + +G+ + +EV +S Sbjct 209 VEREREIQSFVPRPYWVIKLIFEKNGQKFTANYEKDKIWEEE-EGKRIVLEVKKSIPRVS 267 Query 824 ----------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRV-- 871 P PF TL EA F S ++ + IAQ L+E G ++Y RT S ++ Sbjct 268 NVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPR 327 Query 872 ---------SLEGMKVAREYLKLSNLEDYLKNREFYMEGP-HECIRPTKPMDTGELIEFI 921 +L M R Y + LK E E P H I PT E Sbjct 328 NINFRMIIQNLAKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTG--------EIP 379 Query 922 RENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDER--IEGYVDVEFDGWT 979 R + L+K+ KLYD+I RRF+A M+ A ++ I+ + + G V+ GW Sbjct 380 RPGD--LTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVK-KGWL 436 Query 980 RIYNLKLR----KLPKI---EKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPST 1032 +Y ++ LP+ E+ K+ + +K Y V+K M++ G+G +T Sbjct 437 SVYGKYVKFEEVTLPEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKAT 496 Query 1033 YAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 AQI++ L RGY I+ K K+ P LG++V L + P +IS E TRE E+ M+ I Sbjct 497 RAQILETLYQRGY-IEGKKSIKVTP--LGMKVIETLEKYVPEIISVELTREFEKKMELIM 553 Query 1093 RGEVDYIQVLHALK 1106 G + +V+ K Sbjct 554 EGRLTKEEVIEEAK 567 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia typhi str. Wilmington] Sequence ID: Q68X45.1 Length: 779 Range 1: 3 to 561 Score:168 bits(426), Expect:1e-41, Method:Compositional matrix adjust., Identities:179/629(28%), Positives:280/629(44%), Gaps:137/629(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G + + AS GHI DL +K+G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKG--S 41 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V + N + + DI + + ++ I + A Sbjct 42 VLPDKNFAM----------------EYDISDKASKYVD---------------AIVKYAR 70 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNR-----NIYRIGFNEITRRAILRAVEAYRR 720 + + V++ATD D EGE I + + I N+ R+ FNEIT++AI+ AVE R Sbjct 71 KAEAVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIIHAVENPR- 129 Query 721 GEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEE 780 KLD N V +Q RR D +GF LS LW SAGRVQ+ L I +R +E Sbjct 130 ----KLDTNLVNAQQARRALDYLVGFTLSPLLWRKLP-GCKSAGRVQSVALRLICDREDE 184 Query 781 HK--KKVPY--LSLKLEY---DIYVGKIWE-GDFKGEEVEVEVNLYSRDIS--------- 823 + K Y +SLK++ +++ K+ D K ++ + ++D++ Sbjct 185 IERFKAEEYWDISLKMQNSNNELFTAKLTHVNDQKLKKFSIINEKEAKDLTRKLKLQKFY 244 Query 824 ------------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLTTY 863 P PPF T +L +EA ++ S ++ M+IAQ L+E +GL TY Sbjct 245 VEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITY 304 Query 864 HRTSSTRVSLEGMKVAREYLKLSNLEDYLK-NREFYM------EGPHECIRPTKPMDTGE 916 RT +S + + R+ + + YL N Y + HE IRPT Sbjct 305 MRTDGVTLSNDAIADIRKLIDKNYGNKYLPINPRIYQSKVKNAQEAHEAIRPTN------ 358 Query 917 LIEFIREN-NISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVD--- 972 I + +N L K++ KLY+LI++R IA QM+ V +L I ++ + Y+ Sbjct 359 -ITYTPDNLKQKLEKDYYKLYELIWQRTIACQMEN---VIMDLVIANLASENKEYLAKAN 414 Query 973 ---VEFDGWTRIY-----------NLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGEV 1018 + FDG+ ++Y N L L E K K + + P Y E + Sbjct 415 GSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKAQEHIKTKEVIPNKHFTEPPPRYSEASL 474 Query 1019 VKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISE 1078 VK ++E GIGRPSTYA I+ L DR YV + K + IP +LG V +L+ + + Sbjct 475 VKKLEELGIGRPSTYASILSVLQDRKYV--TLEKKRFIPEELGRLVTVFLVGFFKKYVEY 532 Query 1079 EKTRELEEIMDKIERGEVDYIQVLHALKS 1107 + T LE +D+I G++++ L+ S Sbjct 533 DFTAGLENELDEIAAGKLEWKTSLNNFWS 561 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia prowazekii str. Madrid E] Sequence ID: Q9ZDK2.1 Length: 776 Range 1: 3 to 573 Score:167 bits(422), Expect:3e-41, Method:Compositional matrix adjust., Identities:180/642(28%), Positives:288/642(44%), Gaps:147/642(22%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI + G + + AS GHI DL +K+G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKGSV- 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQ--KDIEEILRELIEKGESVKVINCRDNMETIREI 663 + D ++ Y I+D+ K ++ I++E Sbjct 43 --LPDKNFLMEY---------DISDKAGKYVDAIVKE----------------------- 68 Query 664 ADEVDGVFIATDIDTEGEKIGYDIGLNILPFNR-----NIYRIGFNEITRRAILRAVEAY 718 A + + V++ATD D EGE I + + I N+ R+ FNEIT++AI+ AV Sbjct 69 ARKAEVVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIMNAVANP 128 Query 719 RRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERY 778 R KLD N V +Q RR D +GF LS LW SAGRVQ+ L I +R Sbjct 129 R-----KLDTNLVNAQQARRALDYLVGFTLSPLLWRKLP-GCKSAGRVQSVALRLICDRE 182 Query 779 EEHK--KKVPY--LSLKLEY---DIYVGKIWE-GDFKGEEVEVEVNLYSRDIS------- 823 +E + K Y +SLK++ D++ K+ D K ++ + ++D++ Sbjct 183 DEIERFKSEEYWDISLKMQNSNNDLFTAKLTHVNDQKLKKFSIINEKEAKDLTQKLKLQK 242 Query 824 --------------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--------LGLT 861 P PPF T +L +EA ++ S ++ M+IAQ L+E +GL Sbjct 243 FYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLI 302 Query 862 TYHRTSSTRVSLEGMKVAREYLKLSNLEDYL-------KNREFYMEGPHECIRPTKPMDT 914 TY RT +S + + R+ + + YL +++ + HE IRPT T Sbjct 303 TYMRTDGVTLSNDAIADIRKLIDKNYGNQYLPIKPRIYQSKVKNAQEAHEAIRPTNITYT 362 Query 915 GELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVD-- 972 + ++ L K++ KLY+LI+ R IA QM+ V +L I ++ + Y+ Sbjct 363 PDSLK------QKLEKDYYKLYELIWHRTIACQMEN---VIMDLVIANLASENKEYLAKA 413 Query 973 ----VEFDGWTRIY-----------NLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGE 1017 + FDG+ ++Y N L L + E K K + + P Y E Sbjct 414 NGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKEQEHIKTKEVIPNKHFTEPPPRYSEAS 473 Query 1018 VVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLIS 1077 +VK ++E GIGRPSTYA I+ L DR YV + K + IP +LG V +L+ + + Sbjct 474 LVKKLEELGIGRPSTYASILSVLQDRKYV--ALEKKRFIPEELGRLVTVFLVGFFKKYVE 531 Query 1078 EEKTRELEEIMDKIERGEVDYIQVL--------HALKSICDQ 1111 + T LE +D+I G++++ L H ++S+ +Q Sbjct 532 YDFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIESVNEQ 573 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I [Mycolicibacterium smegmatis MC2 155] Sequence ID: A0R5D9.1 Length: 936 Range 1: 17 to 592 Score:166 bits(419), Expect:1e-40, Method:Compositional matrix adjust., Identities:174/641(27%), Positives:266/641(41%), Gaps:156/641(24%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KAR IA + G N ++ +S GHI DL Sbjct 17 LVIVESPTKARKIAGYLGS-------------------NYVVESSRGHIRDLPRNAADVP 57 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 K + + A +N +Q + E + EK +V ++ + Sbjct 58 AKFKSEPW-----ARLGVNVDQ-----NFEPLYIVSPEKKSTVT---------ELKGLLK 98 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +VD +++ATD D EGE I + + L L + R+ F+EIT AI A E R Sbjct 99 DVDELYLATDGDREGEAIAWHL-LETLKPRVPVKRMVFHEITEPAIRNAAENPR-----D 152 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHKK-- 783 LD V +Q RRI DR G+++S LW+ LSAGRVQ+ I++R E Sbjct 153 LDIALVDAQETRRILDRLYGYEVSPVLWKKVAPK-LSAGRVQSVATRIIVQRERERMAFH 211 Query 784 KVPYLSLKLEYDIYV--------------------------------------------- 798 Y + E D V Sbjct 212 SASYWDVTAELDASVSDPSASPPKFTAKLNTVDGRRVATGRDFDSLGQLKRPDEVLVLDE 271 Query 799 ---GKIWEGDFKGEEV---EVEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIA 852 G + G +G ++ VE Y+R P PF T TL +EA ++ S+E M IA Sbjct 272 ASAGALASG-LRGAQLAVTSVEQKPYTR--RPYAPFMTSTLQQEAARKLRFSSERTMSIA 328 Query 853 QDLFELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYL--KNREFY-----MEGPHEC 905 Q L+E G TY RT ST +S + AR + E+Y+ R++ + HE Sbjct 329 QRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQYTRKVKNAQEAHEA 388 Query 906 IRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEA-------------- 951 IRP G++ + + + +L + +LY+LI++R +ASQM +A Sbjct 389 IRPA-----GDVFQTPGQLHSALDTDEFRLYELIWQRTVASQMADARGTTLSLRIGGSAS 443 Query 952 ------------TVVYE---ELYIKDIDERIEGYVDVEFDGWTRIYNLKLRKLPKIEKSK 996 T+ + + Y++ IDE G D D +R+ NL + + Sbjct 444 SGEQVVFNASGRTITFPGFLKAYVESIDELAGGESD---DAESRLPNL-------TQGQR 493 Query 997 LKVLDYSIRKVNKVPL--YDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGK 1054 + D S P Y E ++K ++E GIGRPSTY+ IIK + DRGYV K Sbjct 494 VDAADLSADGHQTSPPARYTEASLIKALEELGIGRPSTYSSIIKTIQDRGYV--QKKGSA 551 Query 1055 LIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGE 1095 L+P+ + V L H+ L+ + T +E+ +D+I G+ Sbjct 552 LVPSWVAFAVVGLLEQHFGRLVDYDFTAAMEDELDEIANGQ 592 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycoplasmoides pneumoniae M129] Sequence ID: P78032.1 Length: 711 Range 1: 5 to 592 Score:161 bits(408), Expect:9e-40, Method:Compositional matrix adjust., Identities:174/643(27%), Positives:293/643(45%), Gaps:141/643(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L+V+ESPNK +T+ + N +E I ++ GHI ++V K +G Sbjct 5 LVVIESPNKVKTLQKYLP----------NDFE---------IVSTIGHIREMVHKN--FG 43 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKG--ESVKVINCRDNMETIREI 663 D Y P++ D ++ L KG + K+++ D +++I+E Sbjct 44 FNEAD--YSPVW-----------EDWTKSKKKFSSLSFKGNLKGKKLLSKYDIIKSIKEK 90 Query 664 ADEVDGVFIATDIDTEGEKIGYDIGLNIL--PFNRNIYRIGFNEITRRAILRAVEAYRRG 721 A + +++ATD D EGE I + + ++L RI FNEIT+ A+L A++ R Sbjct 91 ASKATNIYLATDPDREGEAISWHV-YDVLDEKDKSKCQRITFNEITKNAVLDALKNPR-- 147 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSA---GRVQTPVLGWIIERY 778 ++D++ V+SQ R+I DR IGF+LS L NYLSA GRVQ+ L ++ ER Sbjct 148 ---EIDQSWVQSQFARQILDRMIGFRLSRLL-----NNYLSAKSAGRVQSVALRFLEERE 199 Query 779 EEHKKKVPYLSLKLEYDIYVGKIWEG---------------------------------- 804 +E + VP L D+ + EG Sbjct 200 QEIRSFVPRFWWTL--DVLLNPKAEGVREACANRSIPIVLREINPALRAGLKFEEEKSVS 257 Query 805 --DFK--------GEEVEVEVNLYSRD------ISPSPPFTTDTLLEEATKRFNLSTEEV 848 DF GE+++ +Y+ D SP+ +TT +L ++A + S+++V Sbjct 258 GIDFLDEASAKKFGEQLKGVFEVYNIDETKHYSSSPNSAYTTASLQKDAINKLGWSSKKV 317 Query 849 MRIAQDLFE--------LGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNR----- 895 IAQ L+E L +Y RT STR+S + + +EY+ E YL NR Sbjct 318 TLIAQHLYEGVSINGEQTALISYPRTDSTRLSAQFQQSCKEYILNHYGEKYLSNRIVSAK 377 Query 896 ----EFYMEGPHECIRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEA 951 E ++ HE I PT T E+++ ++ K+ LY LI+ R +AS M + Sbjct 378 GKKGEKIIQDAHEAIHPTDINITPEMVK------NAIKKDEFLLYRLIWIRTVASLMADC 431 Query 952 TVVYEEL-YIKDIDERIEGYVDVEFDGWTRIYN-----------LKLRKLPKIEKSKLKV 999 + + +I D ++ + FDG+ +IY + L K+ ++ K Sbjct 432 KKSHTHIRFINDGNKFYASSKSLVFDGYRKIYEHFENKESNDLYIDLDKIRVGDRFMAKD 491 Query 1000 LDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTK 1059 + + R+ + Y + +++ +++ IGRPSTY + LDRGY S NK T+ Sbjct 492 IKITARQTHPAARYTQASLIEALEKSNIGRPSTYNTMASVNLDRGYA--SLNKHAFHVTQ 549 Query 1060 LGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVL 1102 LG +V L H+ +I++E T+ +E+ +D+I + +Y + L Sbjct 550 LGEQVNEELSKHFGKIINKEFTKNMEKSLDEIAENKKNYQEFL 592 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycobacterium tuberculosis variant bovis AF2122/97] Sequence ID: P0A621.1 Length: 934 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycobacterium tuberculosis CDC1551] Sequence ID: P9WG48.1 Length: 934 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycobacterium tuberculosis H37Rv] Sequence ID: P9WG49.1 Length: 934 Range 1: 20 to 596 Score:162 bits(410), Expect:2e-39, Method:Compositional matrix adjust., Identities:172/632(27%), Positives:263/632(41%), Gaps:138/632(21%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KAR +AS+ G I+ +S GHI DL Sbjct 20 LVIVESPTKARKLASYLGS-------------------GYIVESSRGHIRDLPRAASDVP 60 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 K + + + + + D E + EK R + +R + Sbjct 61 AKYKSQPWARLGVNV----------DADFEPLYIISPEK---------RSTVSELRGLLK 101 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +VD +++ATD D EGE I + + L L + R+ F+EIT AI A E R Sbjct 102 DVDELYLATDGDREGEAIAWHL-LETLKPRIPVKRMVFHEITEPAIRAAAEHPR-----D 155 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--K 783 LD + V +Q RRI DR G+++S LW+ LSAGRVQ+ I+ R + + Sbjct 156 LDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPK-LSAGRVQSVATRIIVARERDRMAFR 214 Query 784 KVPYLSLKLEYDIYVG-------------------KIWEG-DF-------KGEEV----- 811 Y + + D V ++ G DF KG+EV Sbjct 215 SAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDE 274 Query 812 ------------------EVEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQ 853 E Y+R P PPF T TL +EA+++ S E M IAQ Sbjct 275 GSATALAAGLDGTQLTVASAEEKPYAR--RPYPPFMTSTLQQEASRKLRFSAERTMSIAQ 332 Query 854 DLFELGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYL--KNREFY-----MEGPHECI 906 L+E G TY RT ST +S + AR + ++Y+ R++ + HE I Sbjct 333 RLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAI 392 Query 907 RPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDER 966 RP +T + +R + + +LY+LI++R +ASQM +A + L I Sbjct 393 RPAG--ETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITG---- 446 Query 967 IEGYVDVEFDGWTRIYNLKL---------------------RKLPKIEKS-KLKVLDYSI 1004 + G+ +V F R R+LP + +L +++ + Sbjct 447 MSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTP 506 Query 1005 --RKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGI 1062 N Y E +VK ++E GIGRPSTY+ IIK + DRGYV K L+P+ + Sbjct 507 DGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYV--HKKGSALVPSWVAF 564 Query 1063 EVYNYLITHYPHLISEEKTRELEEIMDKIERG 1094 V L H+ L+ + T +E+ +D+I G Sbjct 565 AVTGLLEQHFGRLVDYDFTAAMEDELDEIAAG 596 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Buchnera aphidicola str. APS (Acyrthosiphon pisum)] Sequence ID: P57371.1 Length: 861 Range 1: 1 to 557 Score:162 bits(409), Expect:2e-39, Method:Compositional matrix adjust., Identities:171/611(28%), Positives:278/611(45%), Gaps:108/611(17%) Query 542 LKSILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKE 601 ++ L++VESP KA+TI + G I+ +S GHI DL + Sbjct 1 MQKSLVIVESPAKAKTINQYLGS-------------------EYIVKSSIGHIRDLTKGK 41 Query 602 GYYGVK----IEDNIYIPIYMAIRKINGEQI-TDQKDIEEILRELIEKGESVKVINCRDN 656 Y K + +N I K N +I Q I+ E ++ ++ Sbjct 42 LYNKEKNKKFLNENF-------IEKTNENKILIKQMGIDPYQNWKFE----YHILPGKEK 90 Query 657 M-ETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAV 715 + ++ IA++V +++ATD+D EGE I + + I + R+ FNEIT+ +I +A Sbjct 91 IISELKYIANQVKHIYLATDLDREGEAIAWHLKEVIGGDSSKFSRVVFNEITQHSIQKAF 150 Query 716 EAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWII 775 + ++ N+V +Q RR DR +G+ +S LW+ + LSAGRVQ+ + I Sbjct 151 KNVGH-----INMNRVHAQQARRFMDRIVGYMISPLLWKKIARG-LSAGRVQSVAVRIIA 204 Query 776 ERYEEHKKKVP--YLSL----------KLEYDI--YVGKIW------EGDFKGEEVEVE- 814 +R K VP Y L K+ D+ Y K + E F E+++ Sbjct 205 DRESIIKNFVPEEYWKLDVSLISQDKKKINMDVTHYNNKKFRPINENEVSFAVEKIQKSS 264 Query 815 --VNLYSRDIS---PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSST 869 V Y IS PF T TL + A+ R S ++ M +AQ L+E G TY RT S Sbjct 265 CIVKNYEEKISYLKAPAPFITSTLQQSASLRLGFSVKKTMFLAQKLYEEGYITYMRTDSN 324 Query 870 RVSLEGMKVAREYLKLSNLEDYLK------NREFYMEGPHECIRPTKPMDTGELIEFIRE 923 +S +K R+Y+K + +YL + E + + HE IRP+ I+ Sbjct 325 YLSEYAIKKVRKYIKSNYGSNYLPKEPNIYSNEKHSQEAHEAIRPSD----------IKI 374 Query 924 NNI---SLSKNHIKLYDLIFRRFIASQMKE------ATVVYEELYIKDIDERIEGYVDVE 974 NI L+ + KLY+LI+ +F+ASQMK V +++ ERI V Sbjct 375 KNIDSDHLNSSAKKLYELIWNQFLASQMKSVKYKSITVTVLADMFKLQKSERI-----VM 429 Query 975 FDGWTRIY----NLKLRKLPKIEKSK---LKVLDYSIRKVNKVPLYDEGEVVKLMKERGI 1027 F GW ++ N+ + P ++ + + S + P + E +V+ ++++GI Sbjct 430 FQGWNKVLIEEKNV-FSQFPILQTGSQLFINKVTPSQKFTKPPPRFSEASLVRELEKKGI 488 Query 1028 GRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEI 1087 GRPSTY+ I K+ DRGYV KN K K+G + L + +LI T +E+ Sbjct 489 GRPSTYSAITSKIQDRGYVKIKKN--KFYAEKMGEILTIRLKKSFSNLIDYNFTAHMEKK 546 Query 1088 MDKIERGEVDY 1098 +D++ +V + Sbjct 547 LDQVAENKVTW 557 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q59046.1 Length: 761 Range 1: 6 to 548 Score:159 bits(402), Expect:8e-39, Method:Compositional matrix adjust., Identities:171/591(29%), Positives:273/591(46%), Gaps:90/591(15%) Query 544 SILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKE-- 601 + L++ E P+ A+ IA+ G+ ++ I G+ YE+ +I+ ++ GH+F LV KE Sbjct 6 TALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKENK 65 Query 602 --GYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMET 659 G+Y P++ DI+ + + + E V ++ Sbjct 66 EFGFY----------PVF---------------DIKWVPASVDKGKEYV-----NKYIKA 95 Query 660 IREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYR 719 +++++ + D +IATD D EGE IGY L R+ F+ +T++ I+RA E Sbjct 96 LKKLSKDADEFYIATDWDIEGELIGYH-ALKYCCGREKAKRMRFSSLTKKEIVRAFE--- 151 Query 720 RGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKK----NYLSAGRVQTPVLGWII 775 ++D V + R I D + G LS L + +S GRVQ P L ++ Sbjct 152 --NPDEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLT 209 Query 776 ERYEEHKKKVP--------YLSLKLEYDIYVGKIWE-----------GDFKGEEVEVEVN 816 ER E KK +P L L+ K W D K +V VE+ Sbjct 210 ERELEIKKFIPKPYWVIEALLKDNLKAIHEKEKFWNEKEAKNVYEKIKDEKSAKV-VEIK 268 Query 817 LYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGM 876 R + P PPF TL EA F +S +E IAQ L+E L +Y RTSS ++ + Sbjct 269 KTKRKLKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALISYPRTSSQKLPKD-- 326 Query 877 KVAREYLKLSNLEDYLKNREFYMEGPHECIRPT-KPMD------TGELIEFIRENNISLS 929 R+Y L ++ + +KN Y + ++ KP++ I + LS Sbjct 327 ---RKY--LEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDPAHPAIHIVDIPKEELS 381 Query 930 KNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDE--RIEGYVDVEFDGWTRIY---NL 984 + ++YDLI RR +A+ A Y + I E ++ G V+ +GW IY Sbjct 382 EKEKEIYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFKLSGSRTVK-EGWHEIYYFPKF 440 Query 985 KLRKLPKIEKSK-LKVLDYSI-RKVNKVP-LYDEGEVVKLMKERGIGRPSTYAQIIKKLL 1041 +LP ++K+ +KV +I RK + P Y ++K +++RG+G +T A+II KL+ Sbjct 441 DEIELPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKATRAEIIDKLI 500 Query 1042 DRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIE 1092 RGYVI + G L T LGI V L P +I E+ TR+LEE ++KI+ Sbjct 501 KRGYVI---DDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQ 548 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycoplasmoides genitalium G37] Sequence ID: P47368.1 Length: 709 Range 1: 5 to 586 Score:150 bits(379), Expect:4e-36, Method:Compositional matrix adjust., Identities:173/645(27%), Positives:282/645(43%), Gaps:151/645(23%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L+V+ESPNK +T+ + PS I ++ GHI ++V Y Sbjct 5 LVVIESPNKVKTLKQYL--PSDE----------------FEIVSTVGHIREMV----YKN 42 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 ++N Y PI+ E T K + L+ K E +K I + A Sbjct 43 FGFDENTYTPIW--------EDWTKNKQKNPKQKHLLSKFEIIKSIKAK---------AS 85 Query 666 EVDGVFIATDIDTEGEKIGYDI-GLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEEL 724 + +F+A+D D EGE I + + L RI FNEIT++A++ A++ R Sbjct 86 DAQNIFLASDPDREGEAISWHVYDLLDQKDKAKCKRITFNEITKKAVVDALKQPRN---- 141 Query 725 KLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYL---SAGRVQTPVLGWIIERYEEH 781 +D N V+SQ R+I DR IGF+LS L +YL SAGRVQ+ L ++ ER +E Sbjct 142 -IDLNWVESQFARQILDRMIGFRLSRLL-----NSYLQAKSAGRVQSVALRFLEEREKEI 195 Query 782 KKKVPY----------------------------------LSLKLEYDIYVGKIWEG-DF 806 K VP LS L+ D + G DF Sbjct 196 AKFVPRFWWTVDVLLNKENNQKVVCANKSIPLVLREINPELSASLKLDFEAAENVSGIDF 255 Query 807 KGE--------EVEVEVNLYSRD------ISPSPPFTTDTLLEEATKRFNLSTEEVMRIA 852 E ++ E +Y D SP+P +TT +L ++A + S+++V +A Sbjct 256 LNEASATRFANQLTGEYEVYFIDEPKIYYSSPNPVYTTASLQKDAINKLGWSSKKVTMVA 315 Query 853 QDLFE--------LGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYLKNR--------- 895 Q L+E L +Y RT S R+S + +Y++ YL ++ Sbjct 316 QRLYEGISVNGKQTALISYPRTDSIRISNQFQSECEKYIEKEFGSHYLADKNKLKRHKKD 375 Query 896 EFYMEGPHECIRPT----KPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEA 951 E ++ HE I PT P D + ++ LY LI+ R +AS M +A Sbjct 376 EKIIQDAHEGIHPTYITITPNDLKN----------GVKRDEFLLYRLIWIRTVASLMADA 425 Query 952 TVVYEELYIKDIDERIEGYVDVE---FDGWTRIYN-----------LKLRKLPKIEKSKL 997 ++ I+++ + Y + FDG+ R+Y + L KL +K Sbjct 426 KT--SRTIVRFINQKNKFYTSSKSLLFDGYQRLYEEIKPNTKDELYIDLSKLKIGDKFSF 483 Query 998 KVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIP 1057 + + + K N P Y + +++ +++ IGRPSTY + L+RGY N+ I Sbjct 484 EKISVNEHKTNPPPRYTQASLIEELEKSNIGRPSTYNTMASVNLERGYA-NLVNRFFYI- 541 Query 1058 TKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVL 1102 T+LG +V N L H+ ++I++E T+++E+ +D+I +V+Y + L Sbjct 542 TELGEKVNNELSKHFGNVINKEFTKKMEKSLDEIAENKVNYQEFL 586 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Borreliella burgdorferi B31] Sequence ID: O51768.1 Length: 848 Range 1: 6 to 568 Score:150 bits(378), Expect:1e-35, Method:Compositional matrix adjust., Identities:187/631(30%), Positives:284/631(45%), Gaps:142/631(22%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L++VESP KA+TI F + E CIG + + + + I K + Sbjct 6 LIIVESPTKAKTIKKFLDESF--------LVEACIGHV-VDLPNNAKEIPKEYKKYEWAN 56 Query 606 VKIE-DNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIA 664 + I+ +N + PIY+ +++K I L++L++ TI EI Sbjct 57 ISIDYNNGFNPIYIIP--------SNKKPIVSKLKKLVK---------------TINEI- 92 Query 665 DEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEEL 724 ++ATD D EGE I + + +L +N R+ F+EIT AI +++ R Sbjct 93 ------YLATDQDREGETIAFHLK-EVLKI-KNYKRMIFHEITETAITESLKNTRN---- 140 Query 725 KLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNY-LSAGRVQTPVLGWIIERYE---- 779 +D N V + RRI DR G+ +S LW+ K Y LSAGRVQ+ L +IE+ + Sbjct 141 -IDMNLVNAGEARRILDRLYGYTISPLLWK--KVAYGLSAGRVQSVGLKLLIEKEKTRIN 197 Query 780 -------------EHKKKVPYLSLKLEYDIYVGKIWEG-DF------------------- 806 +H+KK L KLE +I I EG DF Sbjct 198 FKKANYYSILLQCKHEKKNLLLEAKLE-EIDGKNIAEGKDFVNETGKLKNIAKTTIITQD 256 Query 807 ----------KGEEVE-VEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDL 855 G+++E + + I P PFTT TL +E KR + T+++M+ AQ L Sbjct 257 LMIELEKELKNGQKIELISIETKKIKIPPPKPFTTSTLQQEINKRLKIGTKQIMQHAQKL 316 Query 856 FELGLTTYHRTSSTRVS---------LEGMKVAREYLKLSNLEDYLKNREFYMEGPHECI 906 +E G TY RT S ++ + K +EY++ +D + +E + HE I Sbjct 317 YEHGYITYMRTDSHNIAKIAKDKITKIIKNKYGKEYIEE---KDRIYEKEKMAQNAHEAI 373 Query 907 RPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEA-------TVVYEELY 959 RP++ E IE SK ++Y +I+ R I S MK+A T Y+ L Sbjct 374 RPSEIFIPNETIEI-------ESKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLI 426 Query 960 IKDIDERIEGYVDVEFDGWTRIYNLKLRKLPKIEKSKLKVLD-YSIRKV------NKVPL 1012 + + + FDG+ + + L I +K D +SI K+ K P Sbjct 427 FRS------SFTKIIFDGFLKHTKEQDEHL-NINFDLIKKGDTFSIVKMKTSEHETKAPF 479 Query 1013 -YDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITH 1071 Y E +V+ M++ GIGRPSTY+ II LL+R Y K N L+PT G V N L + Sbjct 480 RYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNN--TLMPTIKGAAVINLLEKY 537 Query 1072 YPHLISEEKTRELEEIMDKIERGEVDYIQVL 1102 +P LI T +EE +DKI G++D I+ L Sbjct 538 FPVLIELNFTSNMEEKLDKIAIGKLDKIKYL 568 >RecName: Full=DNA topoisomerase I, plasmid; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Xylella fastidiosa 9a5c] Sequence ID: Q9PHK2.1 Length: 660 Range 1: 3 to 539 Score:148 bits(374), Expect:1e-35, Method:Compositional matrix adjust., Identities:169/608(28%), Positives:256/608(42%), Gaps:122/608(20%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 LM++ESP K +++ G I AS GH+ DL KE G Sbjct 3 LMIIESPGKIEKLSTILGD-------------------GWKIAASVGHVRDLPQKE--MG 41 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 V D + P Y EL E+GE V + ++ + Sbjct 42 VAAPD--FKPSY----------------------ELTERGEGV--------VAKLKNLLK 69 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 + D V++ATD D EGE I + + L + N R+ FNEIT A+ ++ A R Sbjct 70 QADSVYLATDPDREGEAISWHL-QQCLKLS-NPLRVTFNEITANAVKASLVAPR-----T 122 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--K 783 +D +V +Q RR+ DR +G+ +S +L + K LSAGRVQ+P + ++ER E K K Sbjct 123 IDVKRVAAQEARRVLDRLVGYMVSPELSRLTGKR-LSAGRVQSPAVRLVVEREREIKAFK 181 Query 784 KVPYLSLKLEY-DIYVGKIWEGDF-KGEEVEVEVNLY--SRDI----------------- 822 + L + D W ++ + E N Y RD Sbjct 182 VTNHFGAMLFFADAKTSGEWSAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKAVVVKSFDE 241 Query 823 -----SPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVSLEGM- 876 SP PPFTT T+ + A+ + + M AQ L+E G TYHRT + VS E + Sbjct 242 SEAKRSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESLG 301 Query 877 KVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIEFIRENNISLSKNHIKLY 936 + +KL L+ K R+F + P E+ E + + LY Sbjct 302 DIYAVSVKL-GLDIAEKPRKFKAPAGAQVGHPAVTPTHWEVEE------AGETSDQKALY 354 Query 937 DLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVDVEFDGWTRIYN--LKLRKLPKIEK 994 LI R IA Q+ +A + ++ V+ E G T IY LKL + E+ Sbjct 355 KLIRLRAIACQLADARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEE 414 Query 995 ---------------SKLKVLDYS----IRKVNKVPL-YDEGEVVKLMKERGIGRPSTYA 1034 + + LD + + K K P Y + +VK ++ GIGRP+TYA Sbjct 415 EDGNEKESSNPIPVCAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLESEGIGRPATYA 474 Query 1035 QIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERG 1094 I+ ++ RGYV K L PT+ G + + L+ + + TRE+EE +D+I +G Sbjct 475 AIMDNIVSRGYVKTEKK--YLFPTETGELIVDSLVGKF-EFLDLGFTREIEESLDRIAQG 531 Query 1095 EVDYIQVL 1102 E Y V+ Sbjct 532 ESGYKAVI 539 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Buchnera aphidicola str. Sg (Schizaphis graminum)] Sequence ID: Q8K9P7.1 Length: 853 Range 1: 90 to 557 Score:148 bits(374), Expect:4e-35, Method:Compositional matrix adjust., Identities:148/496(30%), Positives:241/496(48%), Gaps:78/496(15%) Query 660 IREIADEVDGVFIATDIDTEGEKIGYD----IGLNILPFNRNIYRIGFNEITRRAILRAV 715 ++ IA++V +++ATD+D EGE I + IG N L F R + FNEIT+++I +A Sbjct 90 LKNIANKVHYIYLATDLDREGEAIAWHLKEVIGGNSLKFRR----VVFNEITKKSIEKAF 145 Query 716 EAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWII 775 + K++ N+V SQ RR DR +G+ +S LW+ + LSAGRVQ+ + I Sbjct 146 QNIG-----KINMNRVYSQQARRFMDRIVGYMISPLLWKKISRG-LSAGRVQSAAVRLIT 199 Query 776 ER-YE-------EHKK-KVPYLSL---KLEYDI--YVGKIWEGDFKGE---EVEVEVNLY 818 +R YE EH K + LS K+ DI Y K + + K E +E NL Sbjct 200 DREYEIKNFIEREHWKISLSLLSKENKKVTMDITHYRNKTFLLNNKKEVNSTIEKIKNL- 258 Query 819 SRDIS----------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSS 868 S I+ P P T TL + + S ++ M +AQ L+E G TY RT S Sbjct 259 SFIITDRKDKIFKKKPPAPLITSTLQQASNIDLGFSVKKTMFLAQKLYEQGYITYIRTDS 318 Query 869 TRVSLEGMKVAREYLKLSNLEDYLKNR------EFYMEGPHECIRPTKPMDTGELIEFIR 922 +S ++ R Y++ D+L + + Y + HE IRP+ ++ + Sbjct 319 YFLSNYAIEKVRSYIENFYGSDFLPKKSNIYSNQKYSQEAHEAIRPSD-------VQVVN 371 Query 923 ENNISLSKNHIKLYDLIFRRFIASQMKE------ATVVYEELYIKDIDERIEGYVDVEFD 976 +N + KLY LI+ FIASQMK T V +++ + +I V F Sbjct 372 IDN--CDPDAKKLYKLIWNYFIASQMKSERYKSIKTTVMADVFKLQSNTKI-----VLFS 424 Query 977 GWTRIY----NLKLRKLPKIEKSKLKVLDYSIRK---VNKVPLYDEGEVVKLMKERGIGR 1029 GWT+I N+ K P ++ +LD + P + E +V+ ++++GIGR Sbjct 425 GWTKILKKSNNVNF-KFPVLDIGTTLILDKILPHQIFTKPPPRFSESSLVRELEKKGIGR 483 Query 1030 PSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMD 1089 PSTYA II K+ ++GY+ KN K K+G + L ++ L+ + T +E+ +D Sbjct 484 PSTYATIITKIKEKGYLKIKKN--KFYAAKIGEILITRLKKNFSDLVDYDFTARMEKNLD 541 Query 1090 KIERGEVDYIQVLHAL 1105 ++ +++ +L++ Sbjct 542 QVSDKLINWKHLLNSF 557 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Streptomyces coelicolor A3(2)] Sequence ID: Q9X909.1 Length: 952 Range 1: 286 to 591 Score:139 bits(350), Expect:3e-32, Method:Compositional matrix adjust., Identities:108/323(33%), Positives:157/323(48%), Gaps:50/323(15%) Query 813 VEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTRVS 872 VE Y R SP PF T TL +EA+++ + M++AQ L+E G TY RT ST +S Sbjct 286 VESKPYRR--SPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYENGYITYMRTDSTTLS 343 Query 873 LEGMKVAREYLKLSNLEDYLKNREFYMEG-------PHECIRPT-----KPMDTGELIEF 920 + AR + DYL + G HE IRP+ P +TG Sbjct 344 DTAVSAARAQVTQLYGADYLPPQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETG----- 398 Query 921 IRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYI-------KDIDERIEGYVDV 973 L+ + KLY+LI++R +ASQMK+AT + I +D++ G + Sbjct 399 -------LTGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGAASDGRDVEFSASGKT-I 450 Query 974 EFDGWTRIY-------NLKL----RKLPKI-EKSKLKVLDYSIR-KVNKVPL-YDEGEVV 1019 F G+ + Y N +L R+LP++ E L + ++ K P Y E +V Sbjct 451 TFHGFLKAYVEGADDPNAELDDRERRLPQVAEGDALTAEEITVDGHATKPPARYTEASLV 510 Query 1020 KLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEE 1079 K ++ER IGRPSTYA II +LDRGYV K L+P+ L V N L H+ L+ + Sbjct 511 KELEEREIGRPSTYASIIGTILDRGYVFKKGT--ALVPSFLSFAVVNLLEKHFGRLVDYD 568 Query 1080 KTRELEEIMDKIERGEVDYIQVL 1102 T +E+ +D+I RGE + L Sbjct 569 FTARMEDDLDRIARGEAQSVPWL 591 Range 2: 14 to 202 Score:72.4 bits(176), Expect:1e-11, Method:Compositional matrix adjust., Identities:72/246(29%), Positives:112/246(45%), Gaps:68/246(27%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVT-----K 600 L++VESP KA+TI + G ++ AS GHI DL + Sbjct 14 LVIVESPAKAKTIKGYLG-------------------PGYVVEASVGHIRDLPSGAAEVP 54 Query 601 EGYY------GVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCR 654 E Y GV +E + + PIY+ +N ++ + K ++++L+ Sbjct 55 EKYTGEVRRLGVDVEHD-FQPIYV----VNADKKSQVKKLKDLLK--------------- 94 Query 655 DNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRA 714 E D +F+ATD D EGE I + + +L + R+ F+EIT+ AI A Sbjct 95 -----------ESDELFLATDEDREGEAIAWHL-QEVLKPKIPVKRMVFHEITKDAIRAA 142 Query 715 VEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWI 774 V R +L++ V +Q RRI DR G+++S LW+ LSAGRVQ+ + Sbjct 143 VANPR-----ELNQKLVDAQETRRILDRLYGYEVSPVLWKKVMPR-LSAGRVQSVATRLV 196 Query 775 IERYEE 780 +ER E Sbjct 197 VERERE 202 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycoplasmoides gallisepticum str. R(low)] Sequence ID: Q9JN65.2 Length: 719 Range 1: 6 to 593 Score:138 bits(347), Expect:4e-32, Method:Compositional matrix adjust., Identities:170/640(27%), Positives:288/640(45%), Gaps:130/640(20%) Query 544 SILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGY 603 S ++V+ESPNK +TI + + YE I A+ GHI DL + Sbjct 6 SKILVIESPNKVKTIKKYL----------TDDYE---------IVATVGHIRDL--PKYT 44 Query 604 YGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREI 663 G ED ++P + E I ++K + + K V N ++ ++ + + Sbjct 45 LGFNTED--FVPKW--------EIIQEKKPAKGVSATKKAKTVKKAVKNKKEIIDELVDK 94 Query 664 ADEVDGVFIATDIDTEGEKIGYDI-------GLNILPFNRNIYRIGFNEITRRAILRAVE 716 A + D +++ATD D EGE I + + G+N+ RI FNEI+ +A+ A+ Sbjct 95 AKKADEIYLATDPDREGEAISWHVYDVLKEKGVNV----NKCKRIIFNEISEKAVKNAIA 150 Query 717 AYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIE 776 R ++ ++ V SQ+ RR DR IGFKLS + K N SAGRVQ+ L +I E Sbjct 151 NPR-----EIQKDWVSSQITRRRLDRLIGFKLSSLMKS--KINADSAGRVQSIALKFITE 203 Query 777 RYEEHKKKVPYLSLKLEY------DIYVGKIWEG----------------DFKGEE---- 810 R E K VP L+ ++ + KI E DF +E Sbjct 204 REELINKFVPRFWWTLDVILKDGTELMLRKIDEKLKDKLGFKELEEVSGIDFNTKEDAEL 263 Query 811 ----VEVEVNLYSRDIS------PSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFE--- 857 + + +Y+ D P + T TL ++A + + ++ +AQ+L+E Sbjct 264 VKQHLSDKYRVYAIDTPKLKSSYPKEVYKTSTLQQDAINKLKWRSMKITSVAQELYEGVT 323 Query 858 -----LGLTTYHRTSSTRVSLEGMKVAREYLKLSNLEDYL-------------KNREFYM 899 + L +Y RT STR+S E K +++ + +DY+ K ++ + Sbjct 324 IDDEQIALISYPRTDSTRLSPEYGKTVLDFVAKTYGKDYVATQSQLNGETKANKKQKAKV 383 Query 900 EGPHECIRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELY 959 + HE I P T + ++ +S + LY LI+ R +A M A VYE + Sbjct 384 QDAHEAIHPIDISITPDSVKN------KISSDQYSLYKLIWTRTVAHYM--AAAVYELVN 435 Query 960 IKDIDERIEGYV---DVEFDGWTRIYNL-----KLRKLP----KIEKSKLKVLDYSIRKV 1007 I+ I+ + Y ++FDG+ +IY LRKL I+K + + D + + Sbjct 436 IRFINNNNKFYAVNNTLKFDGYKKIYTHYDDKDHLRKLDLNHFAIDK-EFEAKDVLLNEH 494 Query 1008 NKVPL--YDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVY 1065 P + + +++ ++ GIGRPSTY+ I+ +L R Y + N T LG ++ Sbjct 495 QTKPPARFTQATLIEALETEGIGRPSTYSTILDIVLKRNYA-ELVNGRYYKTTDLGQKLA 553 Query 1066 NYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHAL 1105 L ++P +I++E T+ +E +D+I +G V+ + L A Sbjct 554 FELDKNFPTIINKEFTKNMETTLDEIAQGTVNDVSYLQAF 593 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycobacterium leprae TN] Sequence ID: O69548.1 Length: 947 Range 1: 293 to 594 Score:126 bits(316), Expect:4e-28, Method:Compositional matrix adjust., Identities:99/318(31%), Positives:145/318(45%), Gaps:50/318(15%) Query 811 VEVEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTYHRTSSTR 870 E LY+R P PPF T TL +EA ++ S E M IAQ L+E G TY RT ST Sbjct 293 ASAEEKLYTR--RPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTT 350 Query 871 VSLEGMKVAREYLKLSNLEDYLKN--REFY-----MEGPHECIRPTKPMDTGELIEFIRE 923 +S + AR + E+Y+ + R++ + HE IRP GE Sbjct 351 LSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPA-----GETFATPDA 405 Query 924 NNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEGYVD----------- 972 L + ++Y+L++RR +ASQM +A L RIEG Sbjct 406 VCNELDGDEFRIYELVWRRTVASQMADARGTTLSL-------RIEGRAGEQHVVFSASGR 458 Query 973 -VEFDGWTRIY------------NLKLRKLPKIEKSKL-KVLDYSI--RKVNKVPLYDEG 1016 + F G+ + Y + R+LP + +L V+D + N Y E Sbjct 459 TLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEA 518 Query 1017 EVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLI 1076 +VK ++E GIGRPSTY+ IIK + DRGYV K L+P+ + V L H+ L+ Sbjct 519 SLVKALEELGIGRPSTYSSIIKTVQDRGYV--QKKGSALVPSWVAFAVTGLLEQHFGRLV 576 Query 1077 SEEKTRELEEIMDKIERG 1094 + T +E+ +D+I G Sbjct 577 DYDFTAAMEDELDEIANG 594 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Thermoplasma acidophilum DSM 1728] Sequence ID: Q9HM08.1 Length: 770 Range 1: 82 to 562 Score:119 bits(299), Expect:3e-26, Method:Compositional matrix adjust., Identities:134/507(26%), Positives:231/507(45%), Gaps:68/507(13%) Query 648 VKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRN-IYRIGFNEI 706 VK I + +T++ +V+ + IATD D EGE IG + L+I+ + I R F+ + Sbjct 82 VKNIKNKVAYQTLQAFRGKVEEIVIATDYDREGELIGVE-ALDIIKEGKEEIRRAKFSAL 140 Query 707 TRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEV----FKKNYLS 762 T+ IL + + + ++ + + R D G L+ + + V K++LS Sbjct 141 TKNEILDSFKNL-----IGVNYSLADAADARESIDLIWGSVLT-RFFSVTTGRLGKSFLS 194 Query 763 AGRVQTPVLGWIIERYEEHKKKVP--YLSLKLEYDI----------------YVGKIWEG 804 AGRVQTP L +++R E + P Y ++ + +D KI+E Sbjct 195 AGRVQTPTLAIVVDREREIQSFRPERYWTISITFDKDGQFKARYPENIKDQDTAEKIYEA 254 Query 805 DFKGEEVEVEVNLYSRD-ISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLTTY 863 KG+ V D I PF+T L EA+ R + + M IA++L+ GL +Y Sbjct 255 -IKGKNGRVSSYTSKEDHIRRPAPFSTTEFLREAS-RIGIMPTKAMSIAENLYMRGLISY 312 Query 864 HRTSSTRVS-----------LEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPM 912 RT +T LE ++ ++ + L +R H P P+ Sbjct 313 PRTDNTVYPRSINLKSVLKKLENTAYSKYVKEIETFDRILPSRGRIETTDHP---PIYPV 369 Query 913 DTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEA--TVVYEELYIKDIDERIEGY 970 D+ + L ++ ++YDLI R F+++ ++ TV E+Y+ + G Sbjct 370 DSPKE---------QLKGDYGRVYDLILRHFLSTLYRDGKKTVAEAEIYVNGYTFKAAGQ 420 Query 971 VDVEFDGWTRIYNLKLRK--LPKI-EKSKLKVLDYSIRK--VNKVPLYDEGEVVKLMKER 1025 + GWT IY + LP++ E LK +D++I++ P YD ++K M+E Sbjct 421 HTTD-RGWTEIYGYDPKDVYLPELTEGEDLKAIDWNIQREETKPPPRYDMSSLLKKMEEL 479 Query 1026 GIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELE 1085 +G ST II KL++RG++ + K PT LG+ + + + H+ E T +LE Sbjct 480 NLGTKSTRHDIIGKLIERGFIEGNPVK----PTPLGMAFIDAVRSVNSHIADPEMTAKLE 535 Query 1086 EIMDKIERGEVDYIQVLHALKSICDQI 1112 E MD+IE+ E+ V+ K + ++ Sbjct 536 EDMDRIEKNEMSKNDVVEESKKMLHEV 562 >RecName: Full=DNA topoisomerase 3-alpha; AltName: Full=DNA topoisomerase III alpha [Drosophila melanogaster] Sequence ID: Q9NG98.2 Length: 1250 Range 1: 29 to 562 Score:107 bits(268), Expect:2e-22, Method:Compositional matrix adjust., Identities:146/579(25%), Positives:245/579(42%), Gaps:104/579(17%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVY------EVCIGDIN--LIITASGGHIFDL 597 L V E + A+TIA + ++ G +VY E + N +++T+ GH+ L Sbjct 29 LNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQL 88 Query 598 VTKEGYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNM 657 + Y + D + ++K G D E I R L +V C+ Sbjct 89 AFQVSYKNWRTVDPRSL-FDAPVKKGVGS------DYEPIKRTL-----EREVRGCQ--- 133 Query 658 ETIREIADEVDGVFIATDIDTEGEKIGY---DIGLNILPFNRNIYRIGFNEITRRAILRA 714 G+ I TD D EGE IGY D+ I P N ++YR F+EIT A+ RA Sbjct 134 -----------GLIIWTDCDREGENIGYEIIDVCRAIKP-NISVYRATFSEITTVAVRRA 181 Query 715 VEAYRRGEELKLDENKVKSQLVRRIE---DRWIGFKLSEKLWEVFKKNYLSAGRVQTPVL 771 ++ + ++ + D V+++L R R+ +L E +S G Q P L Sbjct 182 LQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTL 241 Query 772 GWIIERYEEHKKKV--PYLSLKLEY---DIYVGKIWEGD--FKGEEVEVEVNLYSRDISP 824 G++ ERY+E + V P+ +K+ + D+ V W + F E E + L + P Sbjct 242 GFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDP 301 Query 825 SP--------------PFTTDTLLEE--ATKRFNLSTEEVMRIAQDLFELGLTTYHRTSS 868 P DT+ E +++ LS +E M IA+ L+ G +Y RT + Sbjct 302 RALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTET 361 Query 869 TRVSLEGMKVAREYLKLSNLEDYLKNREFYME-GP-----------HECIRPTKPMDTGE 916 + S E +A + D+ + +E GP H I PTK Sbjct 362 NQFSKE-FALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPIHPTK------ 414 Query 917 LIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDERIEG------- 969 + EN L N ++Y+L+ R F+A K+A ++I E+ Sbjct 415 ----LAEN---LQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHE 467 Query 970 --YVDVE-FDGWTRIYNLKLRKLPKIEKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERG 1026 Y+DV +D W+ + E +++ + + + PL E +++ LM++ G Sbjct 468 RNYLDVYVYDKWSAKQIHHYENGQRFEPTEVSLHEGA---TTAPPLLTEADLIALMEKHG 524 Query 1027 IGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVY 1065 IG +T+A+ I + +RGY I +KG L+P +G+ +Y Sbjct 525 IGTDATHAEHINTIKERGY-IGVLDKGFLVPGVIGMGLY 562 >RecName: Full=DNA topoisomerase 3-alpha [Arabidopsis thaliana] Sequence ID: Q9LVP1.1 Length: 926 Range 1: 3 to 551 Score:100 bits(248), Expect:5e-20, Method:Compositional matrix adjust., Identities:139/601(23%), Positives:241/601(40%), Gaps:125/601(20%) Query 534 RRGKVPDILKSILMVVESPNKARTIASFFGRPSRRKIRGINVYE--------VCIGDINL 585 RRG P ++L V E P+ A+++A R + R G + Y + + Sbjct 3 RRGGGP---VTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRM 59 Query 586 IITASGGHIFDLVTKEGY---YGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELI 642 ++T+ GH+ +L + Y + D P+ + + D+KDI++ Sbjct 60 LMTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPE-------DKKDIKK------ 106 Query 643 EKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIY--R 700 T+ E A + D + + D D EGE I +++ N++ R Sbjct 107 ----------------TLEEEARKSDWLVLWLDCDREGENIAFEVVDVCRAVKHNLFIRR 150 Query 701 IGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVF---- 756 F+ + R I AV+ R +L + + ++ RI + F+ + L + F Sbjct 151 AHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQ-TMLLRDRFAIDS 209 Query 757 ----KKNYLSAGRVQTPVLGWIIERYEEHKKKVP--YLSLKLEYDIYVGKIWEGDFKG-- 808 + +S G Q P LG+I+ERY E + P + ++ + G +G Sbjct 210 TGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLATFNWMRGHL 269 Query 809 ---------------EEVEVEVNL-YSRDISPSPPFTTDT--LLEEATKRFNLSTEEVMR 850 E +N+ + R+ PP+ +T L + A++ F LS+E M+ Sbjct 270 FDYASAVILYEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMK 329 Query 851 IAQDLFELGLTTYHRTS----STRVSLEGM--KVAREYLKLSNLEDYLKNREFYMEGP-- 902 +A++L++ G +Y RT S+R L M + R S + L+ P Sbjct 330 VAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPAN 389 Query 903 -------HECIRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVY 955 H I PTK +GE + S++H+ +Y+L+ R ++A + A Sbjct 390 GGHDDKAHPPIHPTK-FSSGE---------SNWSRDHLNVYELVVRHYLACVSQPAVAAE 439 Query 956 EELYIKDIDERIEG---------YVDV-EFDGWTRIYNLKLRKLPKIEKSKLKV-----L 1000 + I ER Y++V F+ W +P EK + + L Sbjct 440 TTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSV------IPVYEKGQQFIPTTLTL 493 Query 1001 DYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKL 1060 D ++ + PL E +++ M + GIG +T IKKLLDRGY K N + PT L Sbjct 494 DAAVTR--PPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANT-RFSPTNL 550 Query 1061 G 1061 G Sbjct 551 G 551 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Bacillus licheniformis DSM 13 = ATCC 14580] Sequence ID: Q65N90.2 Length: 727 Range 1: 37 to 590 Score:87.0 bits(214), Expect:4e-16, Method:Compositional matrix adjust., Identities:151/606(25%), Positives:241/606(39%), Gaps:132/606(21%) Query 586 IITASGGHIFDLVTKEGY----YGVKIEDNIYIP--IYMAIRKINGEQITDQKDIEEILR 639 I+T + GH+ L EGY ++ED IP + + + K G+Q + + Sbjct 37 IVTWALGHLVTLADPEGYGKEYQSWRLEDLPIIPEPLKLVVIKKTGKQF------QAVKS 90 Query 640 ELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIY 699 +LI K +V + IATD EGE + I + + + Sbjct 91 QLIRK---------------------DVKDIVIATDAGREGELVARWI-IEKAKVTKPLK 128 Query 700 RIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKN 759 R+ + +T +AI + + G++ EN S + R D +G + L F Sbjct 129 RLWISSVTDKAIKDGFKNLKNGKDF---ENLYHSAVARAEADWIVGINATRALTTKFNAQ 185 Query 760 YLSAGRVQTPVLGWIIERYEEHK--KKVPYLSLKLE------------------YDIYVG 799 LS GRVQTP L I +R E+ K K VPY L+ ++ V Sbjct 186 -LSCGRVQTPTLAMIAKREEDIKNFKPVPYFGLRAAVDGMTLTWQDKKTSQTRTFNASVT 244 Query 800 KIWEGDFKGEEVEVEVNLYSRDISPSPPFTTD--TLLEEATKRFNLSTEEVMRIAQDLFE 857 G +G+ V V+L P D L +A KRF S +E + + Q L+E Sbjct 245 SQLAGALQGKPA-VIVDLKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYE 303 Query 858 LG-LTTYHRTSSTRVS----------LEGMKVAREYLKLSNL--EDYLKNREFYMEGP-- 902 L TY RT S +S LEGM+V ++ + N+ F + Sbjct 304 QHKLVTYPRTDSRFLSNDIVPTLKDRLEGMQVKPYAQHVARILKRGVKANKSFVNDAKVS 363 Query 903 -HECIRPTK-PMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMK----EATVVYE 956 H I PT+ P+ G +LS+ KLYDLI +RF+A M E T V+ Sbjct 364 DHHAIIPTEEPLALG-----------ALSEKERKLYDLIAKRFLAVLMPPFEYEETKVFA 412 Query 957 ELYIKDIDERIEGYVDVEFDGWTRIYNL---------KLRKLPKIEKS-KLKVLDYSIRK 1006 E+ + + + V+ GW +Y+ K + LPK+ K L V + K Sbjct 413 EIGGETFTAKGK---TVQSQGWKAVYDFADEDDDEEEKDQTLPKLAKGDTLSVRSLTETK 469 Query 1007 VNKVPL--YDEGEVVKLMKER-------------------GIGRPSTYAQIIKKLLDRGY 1045 P ++EG ++ M+ G+G +T A II+KL + + Sbjct 470 GETKPPARFNEGTLLSAMENPAAFMQGEEKNLVKTLGETGGLGTVATRADIIEKLFNT-F 528 Query 1046 VIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDYIQVLHAL 1105 +I+ K K I +K G ++ + + L S T E E+ + I +G++ + + Sbjct 529 LIEKKGKDIYITSK-GKQLLELVPS---DLKSPALTAEWEQKLSGIAKGKLKSSAFIKEM 584 Query 1106 KSICDQ 1111 K Q Sbjct 585 KEYAKQ 590 >RecName: Full=DNA topoisomerase 3-beta [Oryza sativa Japonica Group] Sequence ID: Q0J0S6.1 Length: 866 Range 1: 1 to 579 Score:86.7 bits(213), Expect:6e-16, Method:Compositional matrix adjust., Identities:150/640(23%), Positives:253/640(39%), Gaps:135/640(21%) Query 541 ILKSILMVVESPNKARTIASFF--GRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLV 598 + ++LMV E P+ A +IAS GR S RK +V+E G H F V Sbjct 1 MAPTVLMVAEKPSIALSIASALSGGRMSTRK-GSTDVHE-------FDGMFQGSHAFFKV 52 Query 599 TKEGYYGVKIEDNIYIPIYMAIRKINGEQITDQKD--IEEILRELIEKGESVKVINCRDN 656 T + + ++ + P Y N E TD D + +LR C Sbjct 53 TSVIGHVLSVD---FPPAYQ-----NWEG-TDPMDLFVAPVLRS-----------ECNPK 92 Query 657 METIREIADEVDG---VFIATDIDTEGEKIGYDI----GLNILPFNRNIYRIGFNEITRR 709 R +A E G + + D D EGE I Y++ G+ R I+R F+ +T + Sbjct 93 AHIRRHLAQEARGCTYLVLWLDCDREGENICYEVIDCTGIPKSEVGRRIFRAKFSSVTEK 152 Query 710 AILRAVEAY---RRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNY------ 760 I+ A+ + E L +D R+ D +G + F+ Y Sbjct 153 DIMDAMNNLVLPSKDEALAVD--------ARQEIDLKVGVAFTRFQTRYFQGKYGNLDSR 204 Query 761 -LSAGRVQTPVLGWIIERYEEHKKKVP--YLSLK-----------LEYD----------I 796 +S G QTP LG+ ++RY++ P + SLK LE+D + Sbjct 205 VISYGPCQTPTLGFCVQRYQQITTFKPEKFWSLKTYVIKDGNEIQLEWDRKKLFDFDVTV 264 Query 797 YVGKIWEGD--FKGEEVEVEVNLYSRDISPSPPFTTDTLLEEATKRFNLSTEEVMRIAQD 854 K+ D K ++ V+ +R P T LL+ A+ + + M +A+ Sbjct 265 MFQKMVASDGILKVTDISVKEECKAR----PPGLNTVNLLKVASSALGIGPQTAMHLAER 320 Query 855 LFELGLTTYHRTSST--------RVSLEGMKVAREYLKLSNL-----EDYLKNREFYMEG 901 L+ G +Y RT ST R +L + A L +++ ++K ++ + G Sbjct 321 LYTQGFISYPRTESTAYPSSFDFRSALAAL--AHNPLWSNDVRTLLDTGFVKPKQGHDAG 378 Query 902 PHECIRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIK 961 H I P + + T E +L + +LY I + FI + + + Sbjct 379 DHPPITPMR-LATEE----------ALGTDAWRLYQYICQHFIGTVSPDCRYTRTSIEFT 427 Query 962 DIDERIEGYVD-VEFDGWTRIYNLKLRKLPKIEKSKLKVLDY------SIRKVN------ 1008 E + V G+T I +P + S+ + Y SI KV+ Sbjct 428 SGGETFHCVGNRVTSKGFTSI-------MPWLAVSENNIPAYKKGDAVSIHKVDIYEGST 480 Query 1009 KVPLY-DEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNY 1067 P Y E E++ LM++ GIG ++ + + +R YV + + +L+PT LG + Sbjct 481 TPPDYLSESELISLMEKNGIGTDASIPVHVNNICERNYVQVNSGR-RLVPTPLGTTLIRG 539 Query 1068 LITHYPHLISEEKTRELEEIMDKIERGEVDYIQVL-HALK 1106 L + R +E+ + I +GE D++QV+ H L+ Sbjct 540 YQCIDADLCLPDIRRFIEQQITLIAKGEADHLQVVQHVLQ 579 >RecName: Full=DNA topoisomerase 3-beta [Arabidopsis thaliana] Sequence ID: F4ISQ7.1 Length: 865 Range 1: 7 to 577 Score:79.3 bits(194), Expect:1e-13, Method:Compositional matrix adjust., Identities:133/612(22%), Positives:237/612(38%), Gaps:94/612(15%) Query 545 ILMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIG-----DINLIITASGGHIFDLVT 599 +LMV E P+ A +IAS RG G + +T+ GH+F + Sbjct 7 VLMVAEKPSIALSIASVLSHGQMSTRRGSTEVHEFDGMFRGFKAHYRVTSVIGHVFSVDF 66 Query 600 KEGYYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMET 659 E Y D +D+ + +I+K + K CR Sbjct 67 PEKY--------------------QNWATIDPQDLFDA--PIIKKESNPKAHICR----- 99 Query 660 IREIADEVDG---VFIATDIDTEGEKIGYDI----GLNILPFNRNIYRIGFNEITRRAIL 712 +++E G + + D D EGE I +++ G ++ R +YR F+ +T + I Sbjct 100 --HLSNEARGCSYMVLWLDCDREGENICFEVIESTGFDMKDSKRKVYRARFSSVTEKDIS 157 Query 713 RAVEAY---RRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNY-------LS 762 +A++ R E L +D R+ D +G S F+ Y +S Sbjct 158 KAMDNLVEPNRDEALAVD--------ARQEIDLKVGVAFSRFQTSYFQGKYQNLDCRVIS 209 Query 763 AGRVQTPVLGWIIERY--------EEHKKKVPYL-----SLKLE------YDIYVGKIWE 803 G QTP LG+ ++RY E+ PY+ L+LE +D+ +++ Sbjct 210 YGPCQTPTLGFCVQRYMHINTFKPEKFWALRPYIRKDGYELQLEWERRRLFDLEAATVFQ 269 Query 804 G-DFKGEEVEVEVNLYSRDISPSPP-FTTDTLLEEATKRFNLSTEEVMRIAQDLFELGLT 861 +G +V +++ P T LL+ A+ + M +A+ L+ G Sbjct 270 KLVVEGRTAKVMDVSEKQEVKGRPAGLNTVNLLKVASSALGFGPQTAMHLAERLYTQGFI 329 Query 862 TYHRTSSTR--VSLEGMKVAREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMDTGELIE 919 +Y RT ST S + R + Y++ +G H T D + Sbjct 330 SYPRTESTAYPSSFDFTDTLRAQVSNPVWGGYVQ--RLLSDGFHMPKSGTDAGDHPPITP 387 Query 920 FIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYE--ELYIKDIDERIEGYVDVEFDG 977 + + + +LY + + F+ + + EL I G E G Sbjct 388 MRAATEVMVGGDAWRLYQYVCQHFLGTVSPNCKYIRTKVELSIGGETFHCTGQRVTE-KG 446 Query 978 WTRIYNLKL---RKLPKIEKS-KLKVLDYSIRKVNKVP--LYDEGEVVKLMKERGIGRPS 1031 +T I +KLP K +++VL + + N P E E++ LM++ GIG + Sbjct 447 FTAIMPWSAVDEKKLPSFLKGERIEVLRVELYEGNTAPPDYLTESELISLMEKHGIGTDA 506 Query 1032 TYAQIIKKLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKI 1091 + A I + +R YV + ++ K++PT LGI + P L + +E+ + + Sbjct 507 SIAVHINNIGERNYV-QVQSGRKMVPTALGITLIRGYQCIDPDLCLPDIRSFIEQQITLV 565 Query 1092 ERGEVDYIQVLH 1103 +G+ D+ V+ Sbjct 566 AKGQADHSHVVQ 577 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P96583.1 Length: 727 Range 1: 37 to 591 Score:77.0 bits(188), Expect:5e-13, Method:Compositional matrix adjust., Identities:145/608(24%), Positives:238/608(39%), Gaps:135/608(22%) Query 586 IITASGGHIFDLVTKEGY----YGVKIEDNIYIP--IYMAIRKINGEQITDQKDIEEILR 639 I+T + GH+ L EGY ++ED IP + + + K G+Q K Sbjct 37 IVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKS------ 90 Query 640 ELIEKGESVKVINCRDNMETIREIADEVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIY 699 +L K +V+ + IATD EGE + I + + I Sbjct 91 QLTRK---------------------DVNQIVIATDAGREGELVARWI-IEKANVRKPIK 128 Query 700 RIGFNEITRRAILRAVEAYRRGEELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKN 759 R+ + +T +AI + R G+E EN S + R D +G + L F Sbjct 129 RLWISSVTDKAIKEGFQKLRSGKEY---ENLYHSAVARAEADWIVGINATRALTTKFNAQ 185 Query 760 YLSAGRVQTPVLGWIIERYEEHKK--KVPYLSLKLEYDIYVGKIWEG------------- 804 LS GRVQTP L I +R + + VPY ++ D + W+ Sbjct 186 -LSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVD-GMTLTWQDKKSKQTRTFNQDV 243 Query 805 ------DFKGEEVEVEVNLYSRDISPSPPFTTDTLLE-EATKRFNLSTEEVMRIAQDLFE 857 + +G++ V + S +P T L+ +A KRF S +E + + Q L+E Sbjct 244 TSRLLKNLQGKQAVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQKLYE 303 Query 858 LG-LTTYHRTSSTRVS----------LEGMKVAREYLKLSNLEDY-LKNREFYME----G 901 L TY RT S +S LEGM+V +S ++ +K+ + Y+ Sbjct 304 QHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDAKVS 363 Query 902 PHECIRPTK-PMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMK----EATVVYE 956 H I PT+ P+ SLS KLYDLI +RF+A M E T V Sbjct 364 DHHAIIPTEEPLVLS-----------SLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIA 412 Query 957 ELYIKDIDERIEGYVDVEFDGWTRIYNLKLRK----------LPKIEKS---KLKVLDYS 1003 E+ + + + V+ GW +Y++ LP ++K ++ L + Sbjct 413 EIGGETFTAKGK---TVQSQGWKAVYDMAEEDDEQEDDRDQTLPALQKGDTLAVRTLTET 469 Query 1004 IRKVNKVPLYDEGEVVKLMKER-------------------GIGRPSTYAQIIKKLLDRG 1044 + ++EG ++ M+ G+G +T A II+KL + Sbjct 470 SGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFN-S 528 Query 1045 YVIKSKNKGKLIPTKLGIEVYNYLITHYPH-LISEEKTRELEEIMDKIERGEVDYIQVLH 1103 ++I+ K + I +K L+ P L S T E E+ + I G++ + Sbjct 529 FLIEKKGQDIFITSK-----GKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSAVFIK 583 Query 1104 ALKSICDQ 1111 +K+ Q Sbjct 584 DMKAYAHQ 591 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Escherichia coli K-12] Sequence ID: P14294.1 Length: 653 Range 1: 3 to 411 Score:68.9 bits(167), Expect:2e-10, Method:Compositional matrix adjust., Identities:110/451(24%), Positives:178/451(39%), Gaps:94/451(20%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L + E P+ AR IA +P R+ G E G + +T GH+ + + Y Sbjct 3 LFIAEKPSLARAIADVLPKPHRK---GDGFIECGNGQV---VTWCIGHLLEQAQPDAY-- 54 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 D+ Y +A I E+ +L + K +N I+ Sbjct 55 ----DSRYARWNLADLPIVPEKW-----------QLQPRPSVTKQLN------VIKRFLH 93 Query 666 EVDGVFIATDIDTEGEKIGYDI--GLNILPFNRN-IYRIGFNEITRRAILRAVEAYRRGE 722 E + A D D EG+ + ++ L + P R + R N++ +A+ RA++ R Sbjct 94 EASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNS 153 Query 723 ELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNY-----LSAGRVQTPVLGWIIER 777 E S L R D G ++ + + + +N LS GRVQTPVLG ++ R Sbjct 154 EFV---PLCVSALARARADWLYGINMT-RAYTILGRNAGYQGVLSVGRVQTPVLGLVVRR 209 Query 778 YEEHKKKVP--YLSLKLE----YDIYVGKIWEGD-----FKGEE--------VEVEVNLY 818 EE + V + +K D IW+ ++ EE E VN Sbjct 210 DEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRI 269 Query 819 S------------RDISPSP-PFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG-LTTYH 864 S R+ +P PF+ L EA KRF LS + V+ I Q L+E L TY Sbjct 270 SGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYP 329 Query 865 RT----------SSTRVSLEGMKV-AREYLKLSNLEDYLKNREFYMEGPHECIRPTKPMD 913 R+ + + + V A + L ++ ++NR C K Sbjct 330 RSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNR---------CWDDKKVDA 380 Query 914 TGELIEFIRENNISLSKNHIKLYDLIFRRFI 944 +I R + I+L++N K+Y+LI R+++ Sbjct 381 HHAIIPTARSSAINLTENEAKVYNLIARQYL 411 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme; Contains: RecName: Full=Endonuclease PI-PfuI; AltName: Full=Pfu topA intein [Pyrococcus furiosus DSM 3638] Sequence ID: O73954.2 Length: 1060 Range 1: 757 to 940 Score:65.9 bits(159), Expect:2e-09, Method:Compositional matrix adjust., Identities:60/188(32%), Positives:96/188(51%), Gaps:13/188(6%) Query 928 LSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDER--IEGYVDVEFDGWTRIYNLK 985 L+K+ LYD+I RRF+A M+ A ++ I + I G V+ +GW R+Y Sbjct 757 LTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVK-EGWLRVYGKY 815 Query 986 LR----KLPKI---EKSKLKVLDYSIRKVNKVPLYDEGEVVKLMKERGIGRPSTYAQIIK 1038 ++ LP E+ K+ + +K Y V+K M++ G+G +T AQI++ Sbjct 816 VKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILE 875 Query 1039 KLLDRGYVIKSKNKGKLIPTKLGIEVYNYLITHYPHLISEEKTRELEEIMDKIERGEVDY 1098 L RGY I+ K K+ P LG++V L + P +IS E TRE E+ M+ I G++ Sbjct 876 TLYQRGY-IEGKKSIKVTP--LGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTK 932 Query 1099 IQVLHALK 1106 +V+ K Sbjct 933 EEVIEEAK 940 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Salmonella enterica subsp. enterica serovar Typhi] Sequence ID: Q8Z6F5.1 Length: 649 Range 1: 3 to 411 Score:63.5 bits(153), Expect:7e-09, Method:Compositional matrix adjust., Identities:106/444(24%), Positives:172/444(38%), Gaps:80/444(18%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L + E P+ R IA +P R+ G E G + +T GH+ + + Y Sbjct 3 LFIAEKPSLGRAIADVLPKPHRK---GDGFIECGNGQV---VTWCIGHLLEQAQPDAY-- 54 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 D+ Y +A I E+ +L + K +N I+ Sbjct 55 ----DSRYARWNLADLPIVPEKW-----------QLQPRPSVTKQLN------VIKRFLH 93 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPF----NRNIYRIGFNEITRRAILRAVEAYRRG 721 + + A D D EG+ + D L+ L + + R N++ +A+ RA++ R Sbjct 94 QAGEIIHAGDPDREGQLL-VDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRAN 152 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNY-----LSAGRVQTPVLGWIIE 776 + S L R D G ++ + + + +N LS GRVQTPVLG ++ Sbjct 153 SDFV---PLCVSALARARADWLYGINMT-RAYTILGRNAGYQGVLSVGRVQTPVLGLVVR 208 Query 777 RYEEHKKKVP--YLSLKLE----YDIYVGKIWEGDFKGEEVEVE---------------- 814 R EE + V + +K D IW+ E + E Sbjct 209 RDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNR 268 Query 815 -------VNLYS--RDISPSP-PFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG-LTTY 863 V Y+ R+ +P PF+ TL EA KRF LS + V+ I Q L+E L TY Sbjct 269 INGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITY 328 Query 864 HRTSSTRVSLEGMKVAREYLKLS---NLEDYLKNREFYMEGPHECIRPTKPMDTGELIEF 920 R S R E R+ + + + D L + + C K +I Sbjct 329 PR-SDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPT 387 Query 921 IRENNISLSKNHIKLYDLIFRRFI 944 R +++ L++N K+Y LI R+++ Sbjct 388 ARSSSVHLTENEAKVYTLIARQYL 411 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Sequence ID: P40687.2 Length: 649 Range 1: 3 to 411 Score:63.5 bits(153), Expect:8e-09, Method:Compositional matrix adjust., Identities:106/444(24%), Positives:172/444(38%), Gaps:80/444(18%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L + E P+ R IA +P R+ G E G + +T GH+ + + Y Sbjct 3 LFIAEKPSLGRAIADVLPKPHRK---GDGFIECGNGQV---VTWCIGHLLEQAQPDAY-- 54 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 D+ Y +A I E+ +L + K +N I+ Sbjct 55 ----DSRYARWNLADLPIVPEKW-----------QLQPRPSVTKQLN------VIKRFLH 93 Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPF----NRNIYRIGFNEITRRAILRAVEAYRRG 721 + + A D D EG+ + D L+ L + + R N++ +A+ RA++ R Sbjct 94 QAGEIIHAGDPDREGQLL-VDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRAN 152 Query 722 EELKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNY-----LSAGRVQTPVLGWIIE 776 + S L R D G ++ + + + +N LS GRVQTPVLG ++ Sbjct 153 SDFV---PLCVSALARARADWLYGINMT-RAYTILGRNAGYQGVLSVGRVQTPVLGLVVR 208 Query 777 RYEEHKKKVP--YLSLKLE----YDIYVGKIWEGDFKGEEVEVE---------------- 814 R EE + V + +K D IW+ E + E Sbjct 209 RDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNR 268 Query 815 -------VNLYS--RDISPSP-PFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG-LTTY 863 V Y+ R+ +P PF+ TL EA KRF LS + V+ I Q L+E L TY Sbjct 269 INGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITY 328 Query 864 HRTSSTRVSLEGMKVAREYLKLS---NLEDYLKNREFYMEGPHECIRPTKPMDTGELIEF 920 R S R E R+ + + + D L + + C K +I Sbjct 329 PR-SDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPT 387 Query 921 IRENNISLSKNHIKLYDLIFRRFI 944 R +++ L++N K+Y LI R+++ Sbjct 388 ARSSSVHLTENEAKVYTLIARQYL 411 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Bacillus thuringiensis str. Al Hakam] Sequence ID: A0R979.1 Length: 729 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [[Bacillus thuringiensis] serovar konkukian str. 97-27] Sequence ID: Q6HP19.1 Length: 729 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Bacillus anthracis] Sequence ID: Q81Z97.1 Length: 729 Range 1: 96 to 556 Score:62.4 bits(150), Expect:2e-08, Method:Compositional matrix adjust., Identities:108/473(23%), Positives:189/473(39%), Gaps:90/473(19%) Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +V+ + +ATD EGE + I ++ + N+ I R+ + +T +AI + G K Sbjct 96 DVNEIIVATDAGREGELVARWI-IDKVRINKPIKRLWISSVTDKAIKDGFANLKPG---K 151 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--K 783 +N S + R D +IG + L F L+ GRVQTP + I R +E K K Sbjct 152 AYDNLYASAVARSEADWYIGLNATRALTTRFNAQ-LNCGRVQTPTVAMIANREDEIKNFK 210 Query 784 KVPYLSLKLEYDIYVGKIWEG------DFKGEEVE-------------VEVNLYSRDISP 824 Y ++ + + W+ F E+++ +E++ + Sbjct 211 AQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFS 270 Query 825 SPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG-LTTYHRTSSTRVSLEGMKVAREYL 883 + L +A K+F S +E + I Q L+E + TY RT S +S + + E L Sbjct 271 PGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERL 330 Query 884 KLSNLEDYLKNREFYMEGPHEC----IRPTKPMDTGELIEFIRENNIS-LSKNHIKLYDL 938 K + +Y ++ P + + +K D +I N S + K+YDL Sbjct 331 KACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDL 390 Query 939 IFRRFIA--------SQMKEATVVYEELYIKDIDERIEGYVDVEFDGWTRIY-------- 982 + +RF+A Q+ T V E +I G + GW +Y Sbjct 391 VVKRFLAVLFPAFEYEQLTLRTKVGNETFI------ARGKT-ILHAGWKEVYENRFEDDD 443 Query 983 ---NLKLRKLPKIEKS---KLKVLDYSIRKVNKVPLYDEGEVVKLMKER----------- 1025 ++K + LP+IEK +K++ + + ++E ++ M+ Sbjct 444 VTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQL 503 Query 1026 --------GIGRPSTYAQIIKKLLD------RGYVIKSKNKGK----LIPTKL 1060 G+G +T A II KL + RG I +KG+ L+P +L Sbjct 504 ADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEEL 556 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Bacillus cereus ATCC 10987] Sequence ID: Q73E74.1 Length: 729 Range 1: 96 to 556 Score:62.0 bits(149), Expect:2e-08, Method:Compositional matrix adjust., Identities:107/473(23%), Positives:188/473(39%), Gaps:90/473(19%) Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +V+ + +ATD EGE + I ++ + N+ I R+ + +T +AI + G Sbjct 96 DVNEIIVATDAGREGELVARWI-IDKVRINKPIKRLWISSVTDKAIKDGFANLKPGRAY- 153 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--K 783 +N S + R D +IG + L F L+ GRVQTP + I R +E K K Sbjct 154 --DNLYASAVARSEADWYIGLNATRALTTRFNAQ-LNCGRVQTPTVAMIANREDEIKNFK 210 Query 784 KVPYLSLKLEYDIYVGKIWEG------DFKGEEVE-------------VEVNLYSRDISP 824 Y ++ + + W+ F E+++ +E++ + Sbjct 211 AQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVMEIDKKQKKSFS 270 Query 825 SPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG-LTTYHRTSSTRVSLEGMKVAREYL 883 + L +A K+F S +E + I Q L+E + TY RT S +S + + E L Sbjct 271 PGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERL 330 Query 884 KLSNLEDYLKNREFYMEGPHEC----IRPTKPMDTGELIEFIRENNIS-LSKNHIKLYDL 938 K + +Y ++ P + + +K D +I N S + K+YDL Sbjct 331 KACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDL 390 Query 939 IFRRFIA--------SQMKEATVVYEELYIKDIDERIEGYVDVEFDGWTRIY-------- 982 + +RF+A Q+ T V E +I G + GW +Y Sbjct 391 VVKRFLAVLFPAFEYEQLTLRTKVGNETFI------ARGKT-ILHAGWKEVYENRFEDDD 443 Query 983 ---NLKLRKLPKIEKS---KLKVLDYSIRKVNKVPLYDEGEVVKLMKER----------- 1025 ++K + LP+IEK +K++ + + ++E ++ M+ Sbjct 444 VTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQL 503 Query 1026 --------GIGRPSTYAQIIKKLLD------RGYVIKSKNKGK----LIPTKL 1060 G+G +T A II KL + RG I +KG+ L+P +L Sbjct 504 ADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEEL 556 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Bacillus cereus E33L] Sequence ID: Q63GK5.1 Length: 729 Range 1: 96 to 556 Score:61.6 bits(148), Expect:3e-08, Method:Compositional matrix adjust., Identities:106/468(23%), Positives:188/468(40%), Gaps:80/468(17%) Query 666 EVDGVFIATDIDTEGEKIGYDIGLNILPFNRNIYRIGFNEITRRAILRAVEAYRRGEELK 725 +V+ + +ATD EGE + I ++ + N+ I R+ + +T +AI + G K Sbjct 96 DVNEIIVATDAGREGELVARWI-IDKVRINKPIKRLWISSVTDKAIKDGFANLKPG---K 151 Query 726 LDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKKNYLSAGRVQTPVLGWIIERYEEHK--K 783 +N S + R D +IG + L F L+ GRVQTP + I R +E K K Sbjct 152 AYDNLYASAVARSEADWYIGLNATRALTTRFNAQ-LNCGRVQTPTVAMIANREDEIKNFK 210 Query 784 KVPYLSLKLEYDIYVGKIWEG------DFKGEEVE-------------VEVNLYSRDISP 824 Y ++ + + W+ F E+++ +E++ + Sbjct 211 AQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFS 270 Query 825 SPPFTTDTLLEEATKRFNLSTEEVMRIAQDLFELG-LTTYHRTSSTRVSLEGMKVAREYL 883 + L +A K+F S +E + I Q L+E + TY RT S +S + + E L Sbjct 271 PGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERL 330 Query 884 KLSNLEDYLKNREFYMEGPHEC----IRPTKPMDTGELIEFIRENNIS-LSKNHIKLYDL 938 K + +Y ++ P + + +K D +I N S + K+YDL Sbjct 331 KACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDL 390 Query 939 IFRRFIASQMKEATVVYEELYIKD---IDERIEGYVDVEFDGWTRIY-----------NL 984 + +RF+A YE+L ++ + I + GW +Y + Sbjct 391 VVKRFLAVLF--PAFEYEQLTLRTKIGNETFIARGKTILHAGWKEVYENRFEDDDVTDEV 448 Query 985 KLRKLPKIEKS---KLKVLDYSIRKVNKVPLYDEGEVVKLMKER---------------- 1025 K + LP+IEK +K++ + + ++E ++ M+ Sbjct 449 KEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLK 508 Query 1026 ---GIGRPSTYAQIIKKLLD------RGYVIKSKNKGK----LIPTKL 1060 G+G +T A II KL + RG I +KG+ L+P +L Sbjct 509 STGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEEL 556 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Vibrio cholerae O1 biovar El Tor str. N16961] Sequence ID: Q9KQF5.1 Length: 647 Range 1: 4 to 417 Score:57.8 bits(138), Expect:5e-07, Method:Compositional matrix adjust., Identities:111/461(24%), Positives:181/461(39%), Gaps:109/461(23%) Query 546 LMVVESPNKARTIASFFGRPSRRK---IRGINVYEVCIGDINLIITASGGHIFDLVTKEG 602 L + E P+ AR IA +P +++ IR N GDI +T GH+ + V + Sbjct 4 LFIAEKPSLARAIADALPKPHKKEQGCIRCAN------GDI---VTWCIGHLLEQVEPDA 54 Query 603 YYGVKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIRE 662 Y D Y MA I EQ LR + + V+ R+ Sbjct 55 Y------DERYKKWNMADLPIIPEQWQ--------LRPRKSSSQQLTVV---------RK 91 Query 663 IADEVDGVFIATDIDTEGEKIGYD-IGLNILPFNR--NIYRIGFNEITRRAILRAVEAYR 719 + E + A D D EG+ + + I +P ++ + R+ +++ A+ RA++ R Sbjct 92 LLKEATQIIHAGDPDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLR 151 Query 720 RGEE-LKLDENKVKSQLVRRIEDRWIGFKLSEKLWEVFKK----NYLSAGRVQTPVLGWI 774 E + L S L R D G +S + KK LS GRVQTPVLG + Sbjct 152 SNREFIPLS----VSALARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLV 207 Query 775 IERYEEHKKKVPYLSLKLE-----------YDIYV-GKIWEGDFKGEEVEVEV------- 815 + R EE + +P+ L+ +DI K E ++ E V Sbjct 208 VRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVD 267 Query 816 NLYSRDISPSP-----------------PFTTDTLLEEATKRFNLSTEEVMRIAQDLFE- 857 N+ SR I+ P P++ L +A KR+N S ++V+ + Q L+E Sbjct 268 NVASR-IANQPATVTESEQDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEK 326 Query 858 LGLTTYHRTSSTRVSLEGMKV-----------AREYLKLSNLEDYLKNREFYMEG---PH 903 L TY R+ + E + A+E + N D + + + H Sbjct 327 HKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAH 386 Query 904 ECIRPTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFI 944 I PT + + +LS + +K+Y LI R+++ Sbjct 387 HAIIPTPK----------KASVNALSGHEMKVYQLIARQYL 417 >RecName: Full=DNA topoisomerase 3; AltName: Full=DNA topoisomerase III [Haemophilus influenzae Rd KW20] Sequence ID: P43704.1 Length: 651 Range 1: 3 to 607 Score:52.4 bits(124), Expect:2e-05, Method:Compositional matrix adjust., Identities:138/649(21%), Positives:244/649(37%), Gaps:130/649(20%) Query 546 LMVVESPNKARTIASFFGRPSRRKIRGINVYEVCIGDINLIITASGGHIFDLVTKEGYYG 605 L + E P+ AR IA +P +R I GD N ++T GH+ + Sbjct 3 LFIAEKPSLARAIADVLPKPHQRGDGFIKC-----GD-NDVVTWCVGHLLE--------- 47 Query 606 VKIEDNIYIPIYMAIRKINGEQITDQKDIEEILRELIEKGESVKVINCRDNMETIREIAD 665 + E + Y P + R E L + EK + + + + + ++ Sbjct 48 -QAEPDAYDPKFKQWRL-------------EHLPIIPEKWQLLPRKEVKKQLSVVEKLIH 93 Query 666 EVDGVFIATDIDTEGEKIGYDIG--LNILPFNRN-IYRIGFNEITRRAILRAVEAYRRGE 722 + D + A D D EG+ + ++ N+ R+ I R +++ A+ +AV+ Sbjct 94 QADTLVNAGDPDREGQLLVDEVFSYANLSAEKRDKILRCLISDLNPSAVEKAVK------ 147 Query 723 ELKLDENK-----VKSQLVRRIEDRWIGFKLSEKLW----EVFKKNYLSAGRVQTPVLGW 773 KL N+ S L R D G ++ + LS GRVQTPVLG Sbjct 148 --KLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQTGYDGVLSVGRVQTPVLGL 205 Query 774 IIER--------------------YEEHKKKVPYLSLKLEYDIYVGKIWEGDFKGEEVEV 813 I+ R E ++K P S L ++ D++ ++ V Sbjct 206 IVRRDLEIEHFQPKDFFEVQAWVNPESKEEKTPEKSTALFSALWQPSKACEDYQDDDGRV 265 Query 814 ------------------EVNLYS--RDISPSP-PFTTDTLLEEATKRFNLSTEEVMRIA 852 EV Y R+ +P P++ L +A KRF +S + V+ Sbjct 266 LSKGLAEKVVKRITNQPAEVTEYKDVREKETAPLPYSLSALQIDAAKRFGMSAQAVLDTC 325 Query 853 QDLFELG-LTTYHRTSSTRVSLEGMKVAREYLKL--SNLEDY--LKNREFYMEGPHECIR 907 Q L+E L TY R+ + E L ++ E Y L N E + C Sbjct 326 QRLYETHRLITYPRSDCRYLPEEHFAERHNVLNAISTHCEAYQVLPN-VILTEQRNRCWN 384 Query 908 PTKPMDTGELIEFIRENNISLSKNHIKLYDLIFRRFIASQMKEATVVYEELYIKDIDER- 966 K +I + ++L++ +Y LI R+++ +A ++ + Sbjct 385 DKKVEAHHAIIPTAKNRPVNLTQEERNIYSLIARQYLMQFCPDAEYRKSKITLNIAGGTF 444 Query 967 IEGYVDVEFDGWTRIYNLKLRK------LPKIEKSKLKVLD----YSIRKVNKVPLYD-- 1014 I +++ GW + + LP ++K ++ + S + P D Sbjct 445 IAQARNLQTAGWKELLGKEDDTENQEPLLPIVKKGQILHCERGEVMSKKTQPPKPFTDAT 504 Query 1015 -------------EGEVVKLMKER-GIGRPSTYAQIIKKLLDRGYVIKSKNKGKLIPTKL 1060 + E+ K+++E G+G +T A II+ L RG++ K KG+ I + Sbjct 505 LLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLTK---KGRNIHS-- 559 Query 1061 GIEVYNYLITHYPHLISE-EKTRELEEIMDKIERGEVDYIQVLHALKSI 1108 E LI P++ ++ + T E + I + + Y Q +H L I Sbjct 560 -TETGRILIQALPNIATQPDMTAHWESQLTDISQKQATYQQFMHNLNQI 607 >RecName: Full=UvrABC system protein B; Short=Protein UvrB; AltName: Full=Excinuclease ABC subunit B [Colwellia psychrerythraea 34H] Sequence ID: Q480C7.1 Length: 673 Range 1: 269 to 520 Score:44.3 bits(103), Expect:0.006, Method:Compositional matrix adjust., Identities:71/286(25%), Positives:115/286(40%), Gaps:64/286(22%) Query 140 RAQSLVGDNIKVVCYHSELSEREKRDIKKRIEEGDFQVLITTSNYLTR----NMPPTTFD 195 R+Q L DN K+V L++R + DI+ E G + S YL+ PPT FD Sbjct 269 RSQQL-KDNNKLV-EEQRLTQRTQFDIEMMTELGYCSGIENYSRYLSGREEGGAPPTLFD 326 Query 196 F-------------IFVDDVDALLKSSKNIDRTLLLLGFSRELIDEAYKIILLMKWRKFD 242 + + V + A+ K ++ L+ GF + Sbjct 327 YLPDDGLLIIDESHVTVPQIGAMYKGDRSRKENLVEYGF------------------RLP 368 Query 243 KALELREKLRKKLEGIKHGCIVIASAT--------GKSYGDKVKLYRELLNFEVGYGINK 294 AL+ R ++ E I I +++ G ++V LL+ E+ + Sbjct 369 SALDNRPMKFEEFEAISPQTIYVSATPSKFELEKCGSDIAEQVVRPTGLLDPEI-----E 423 Query 295 LRDVVDVYDEIDRDKVLEYVKLLGPGGLIFVSQDYGLEVAKDIENLLRENNIKAKVVHS- 353 +R V E D +L + P ++ +A+D+ + L ++ IKA+ +HS Sbjct 424 VRPV-----ETQVDDLLSEINKRLPLDERVLATTLTKRMAEDLTDYLYDHGIKARYLHSD 478 Query 354 ----KDKEGFEDFRTGKIDVLIGVASYYGVLVRGLDMPERVRYAIF 395 + E DFR GK DVL+G+ +L GLDMPE AI Sbjct 479 VDTVERVEIIRDFRLGKFDVLVGI----NLLREGLDMPEVSLVAIL 520 >RecName: Full=Probable helicase HelY [Mycobacterium tuberculosis CDC1551] Sequence ID: P9WMR0.1 Length: 906 >RecName: Full=Probable helicase HelY [Mycobacterium tuberculosis H37Rv] Sequence ID: P9WMR1.1 Length: 906 Range 1: 2 to 115 Score:42.7 bits(99), Expect:0.020, Method:Compositional matrix adjust., Identities:35/133(26%), Positives:54/133(40%), Gaps:25/133(18%) Query 63 NEFKKFDRFCKELGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSLFG-LLMSLYLADRG 121 E + DRF EL + L Q+ + + + APTG GK++ G + L LA G Sbjct 2 TELAELDRFTAELPFSLDDFQQRACSALERGHGVLVCAPTGAGKTVVGEFAVHLALAA-G 60 Query 122 KRCYIILPTTLLVKQTYERAQSLVGDNIKVVCYHSELSEREKRDIKKRIE-----EGDFQ 176 +C+ P L Q H++L+ R RD + G+ Sbjct 61 SKCFYTTPLKALSNQK-----------------HTDLTARYGRDQIGLLTGDLSVNGNAP 103 Query 177 VLITTSNYLTRNM 189 V++ T+ L RNM Sbjct 104 VVVMTTEVL-RNM 115