>A0A1M7PUP6_9ACTN/27-467 Hercynine oxygenase
APAPQGSAQAPPVRALAALEAARRRTELLTDSVDEHD-LTAQHS-PLMSPLVWDLAHIGNQE-ELWLVRE-A
GGRP-GLRPDLD-HVYDAF------RTPRADRPALPLLGPAEARAYLAAVREQTAEVLESVDTGPDQPER--
LLADAFVFGMLAQHEQQHDETMLATHQLRVGPPVLDA-P-EPPP-A---PAD-------VALLPREVHIPGG
AFTMG----------T----ST--EP-WALDNELPAHSVEVPGFWLDTVPVTNGAYAEFIAAGGYDEPAWWA
PEGWRHVREAGLVAPLFWD---RDG----------EGWT-RRRFGRTEPVPADEPVLHVCWYEADAYARWA-
----GR--RLPTEAEWEKAARHDPATGRSRRYPWGDADPG--PEHANLGQRHLRPAPAGSYPAGAAPSGARQ
LVGDV-WEWTASDFAPYPGFAAFPY-------KEYSDVFF----GP-----DYKVLRGGAFGVAPV----AA
RSTFRNWDYPIRRQIF--------------------------------------------------------
-------------------AGFRTARDE
>A0A540W201_9ACTN/2-441 Hercynine oxygenase
LNPDAGEERLRETI-ADELLAARTRTGLLTESVDDVE-LSAQHS-RLMSPLVWDLAHIGNQE-ELWLLRN-V
GGRD-PMHPEID-PLYDAF------QHPRAERPTLPLLPPDEARRYAAEVRGRVLDLLDGVALAGPPL----
L-QAGFAFGLIAQHEQQHDETMLITHQLRTGEPVLTA----PAP-G---PAP-------AERLPAEVLVPAG
PFTMG----------T----DT--EP-WALDNERPAHQVDLPGFAIDTTPVSNAAYQRFIEDGGYQEPRWWS
TAGWQHCRQAELTGPLFWT---RQD----------GVWL-RRRFGRVEQVPPEEPVLHVTWYEAEAYARWA-
----GR--RLPTEAEWEKAARHDPVTGRSRRFPWGDGPPG--PEHANLGQRHLQPAPVGSYPAGESPYGARQ
LIGDV-WEWTASDFAPYPGFRAWPY-------REYSEVFF----AGPGQPAEYKVLRGGSFAVAPV----AC
RGTFRNWDYPIRRQIF--------------------------------------------------------
-------------------AGFRTARDL
>A0A3N8KJ93_9BURK/1-410 
-------MSLLASQLQRRYRDVRAGSVELTATLSAED-QAVQSM-PDASPVKWHLAHTTWFF-ETVVLMRRV
GGYA-PFDDAYA-FLFNSYYESLGPRHPRPQRGLLTRPSLDEVHAYRQYVDDAMLRMLADADASL-------
LDTIAPELELGLHHEQQHQELIVTDMLHAFSCNPLLP-AFRPRD-G---AREAHTR---EADTLRWLRQPGG
LVEIG----------H----DG--HG-FSFDNERPRHTALLRPYDIADRLVTNAEFAAFIADGGYARPEFWL
SDGWATVQREGWCAPAYWI---VEDEDEPEPAPPYDAPQRAYGLHGAEPLAPDAPVCHVSFYEAAAYAEWA-
----GA--RLPTEFEWEAAYCAD---------------------------------------------GIRQ
MTGHA-WQWTRSSYEPYPGFRPLAGVA-----AEYNGKFM----VG-----QQ-VLRGSSIATPPG----HA
RPTYRNFFPPAARWQF--------------------------------------------------------
-------------------TGVRLARDV
>A0A482ILH7_9BURK/5-429 
LLPAAASHPPQEPALLSQYRHVRSATEAMVADLSDAD-ATVQSM-DDASPAKWHLAHTTWFF-EEFVLSARL
PDYE-PVDPQYR-YLFNSYYEAVGARHPRPRRGLLTRPSLDEVLAYREAVDEAMESLLMRAQ----------
TDDEAALITLGLHHEQQHQELLLTDILHLFAQNPLRP-AYAPTLPS---PVIAD-----PRPAPEWIAFPGG
VVTIG----------H----SG--DG-FAFDCEGPRHQVLLQPYLLCSHPVSNHQWFEFIEDGGYQSTGLWL
SDGWRWVCDNQIEAPLYWE---ERD----------GTWW-QMTLRGMQPVDPDSPVTHVSFFEADAFARWA-
----ER--RLPTEAEWEHAAHNLP------------------ATGNFAEGRALRPLPDRQNTAG----SLRQ
MFGDV-WEWTGSAFLPYPRFRPREGAV-----GEYNGKFM----SS-----QM-VLRGGSCVTAES----HI
RASYRNFFYPHQRWQF--------------------------------------------------------
-------------------TGVRLADDA
>EGTB_MYCTO/1-425 Hercynine oxygenase
--------MTSPEQLACHLARARARTLRLVD-FDDAE-LCCQYD-PLMSPLVWDLAHIGQQE-ELWLLRGGD
PGQPGLLPPAVE-GLYDAF------EHSRASRVELPLLSPARARSYCATVRSAALDALAALP----------
EDGDSFVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAG-R-------------PRMAGTSVLVAGG
PFVLG----------V----DAADEP-CSLDNERQAHVVDVPAFRIGRVPVTNGEWQDFIDDGGYTQSRWWS
ERGWQHRQRAGLTAPQFWR---SGGR---------T----RTRFGHVEDIPADEPVQHVSYFEAEAYAAWA-
----GA--RLPTEVEWEKACAWDPATGSRRRYPWGTEEPT--DTYANLGGQTLRPAPVGAYPAGASACGAEQ
MLGDV-WEWTTSPLRPWPGFVPMVY-------ERYSQPFF----GG-----DYRVLRGGSWAVEPA----IL
RPSFRNWDHPYRRQIF--------------------------------------------------------
-------------------AGVRLAWDI
>EGTB_MYCT3/1-433 Hercynine oxygenase
--MTGVAVPHRAEL-ARQLIDARNRTLRLVD-FDDAE-LRRQYD-PLMSPLVWDLAHIGQQE-ELWLLRGGD
PRRPGLLEPAVE-QLYDAF------VHPRASRVHLPLLSPAQARRFCATVRSAVLDALDRLP----------
EDADTFAFGMVVSHEHQHDETMLQALNLRSGEPLLGSGTALPPG-R-------------PGVAGTSVLVPGG
PFVLG----------V----DLADEP-YALDNERPAHVVDVPAFRIGRVPVTNAEWRAFIDDGGYRQRRWWS
DAGWAYRCEAGLTAPQFWN---PDGT--------------RTRFGHVEDIPPDEPVQHVTYFEAEAYAAWA-
----GA--RLPTEIEWEKACAWDPATGRRRRYPWGDAAPT--AALANLGGDALRPAPVGAYPAGASACGAEQ
MLGDV-WEWTSSPLRPWPGFTPMIY-------QRYSQPFFEGAGSG-----DYRVLRGGSWAVAAD----IL
RPSFRNWDHPIRRQIF--------------------------------------------------------
-------------------AGVRLAWDV
>A0A430DID7_9SPHN/1-419 
-MQDIQYEPAYPPL-QSRFAGVRALSEALVAPLSDAD-ASVQSM-PDASPAKWHLAHTSWFF-ETFVLRDHV
SGYT-LHDPRFP-FLFNSYYEAEGKRHARARRGMVTRPSLDEVLGYRHAVTQAVLENWERL-----------
PRQAMELVELGCQHEQQHQELLLTDILHLFSENPIEP-ALWPAPRK---QPVA------VPPPTGWIEHPGG
IVEVG----------H----DG--ES-FAFDCEGPRHRALLHPHAIADRTVTNGEWAAFVADGGYREPRHWL
SDGWNWVQREGITAPLYWA---EGEG---------GGWT-RFGLDGRRPVDPAAPVTHVSFYEADAYASWA-
----GA--RLPTEQEWEAAAA---------------------GEDAGGGNQLDGPGPLEPRPAA----AAPA
FFGDV-WEWTGSAYRPYPGFQTAEGAV-----GEYNGKFM----SG-----QF-VLRGGSCATPRG----HL
RASYRNFFYPHQRWQF--------------------------------------------------------
-------------------TGVRLAKDL
>A0A2M8QT88_9SPHN/1-422 
-MGKSRTAPSQIDL-ITRYREVRALSEALAAPLSDAD-ATVQSM-ADASPAKWHLAHASWFF-ETFVLRDHV
PGYT-PFDARYA-FLFNSYYEAEGPRHARPMRGMLTRPSLKDVRAYRAHVDKALVTALPML-----------
KPEVQALVLLGLNHEQQHQELMLTDIQHLLSLNPLEPALFDAPNAL---PAP-------IPGPLHWIEGRQG
LVEIG----------D----DG--KGDFAFDCEGPRHKAVLHPHALAHRLITNGEWIDFIEDGGYARTSHWL
SDGWAWVQAEGIEAPLYWK---RNE----------QGWT-RYGLDGRKPVNRAAPVTHISLYEADAYAHWA-
----GF--RLPTEAEWESAALNIAPT--------------------SGNQLDGAACPRARAAEGGS--ALTQ
MFGDV-WEWTGSAYRPHPGFRAAEGAV-----GEYNGKFM----SG-----QF-VLKGGSCATPRG----HV
RASYRNFFYPHQRWQF--------------------------------------------------------
-------------------TGLRLAKDL
>A0A3P3F114_9BURK/1-418 
MTLSRPITQTASAL-RDKFREVRAASLALAAPLSAED-QCIQSM-PDASPTKWHLAHTTWFF-ETVLLQPHA
AGYR-PFDERFH-YLFNSYYEALGPRHPRPQRGLLTRPSVDEVHAYRAHVDEAVLALLD--GGDGERG----
WAAIEPIVTLGLHHEQQHQELLLTDILHALSCNPLLP-AYRPAA-G---PALRLAA---VPPAMRWLPQPGG
MVQVG----------H----GGPQQG-FAFDNETPRHAALLQPYAIADRLVSCGDYAQFIADGGYQRPELWL
SDGWAAVQAQGWRHPAYWL---AADDPRLQGLQPQGGWQ-VFGLHGVRPMEADAPVSQLSFYEAAAYAEWA-
----GA--RLPTEFEWEAAFDAP---------------------------------------------GISQ
MTGHV-WQWTRSSYDPYPGFRPMPGIA-----AEYNGKFM----VG-----QL-VLRGGSVATPPG----HS
RPSYRNFFPPAARWQF--------------------------------------------------------
-------------------SGLRLAKDI
>A0A2M8X449_9BURK/1-395 
--------MTSCAL-PFRYVDVRNRSVALAAPLSAED-CGAQSM-PDASPTKWHLAHTTWFF-ETFVLESHE
PGFA-PFAPAFR-VLFNSYYNGVGAKHPRPQRGLLTRPSLDEVLAYRADVDARMACLWPTVAH---------
DAALCALVGLGLQHEQQHQELMLTDILHLLSCNPLFP-AYADASAA---VMPE------AAEAMAWQPFEGG
LTEIG----------H----AG--SG-FAFDNEGPRHRVYLRPYVLASRLVTQAEYLAFVEGGGYRNPLLWL
AEGWDWRAALGLEQPLYWH---RID----------GAWH-QFTLAGLQPLQGNQPVLHLSYYEADAYARWV-
----GA--RLPTEAEWEHAAAQATS-------------------------------------------GMAQ
WQGAA-WQWTQSSYAPYPGFRVAEGAV-----GEYNGKFM----VN-----QY-VLRGSSSATPPG----HE
RLTYRNFFPATARWQF--------------------------------------------------------
-------------------TGIRLARDL
>A0A0K0GG05_XANOP/1-411 
-----------MTL-LERYAQTRALSDRLAAPLSAED-AMVQSM-PDASPSKWHLAHTTWFF-ERFVLQT-D
PAYR-VFDPAWD-FLFNSYYQSVGPMHARACRGVLSRPALQQVRDYRAVVDAQIQQRLR-----DGLL----
DAQACIIVQLGIQHEQQHQELLLTDIKHALWSNPLQT-AYRDAA-A---PPTA------VASTLRWHARDEQ
IVEIG----------AAAWPQA--DT-FAYDNESPRHRVLVGAHALANRVVTNAEFQEFIDAGGYRSAVAWL
SDGWAMVQAQGWQHPLYWD---ADG----------R----EFTLDGWRTRDPHAPVCHLSLFEADAFARWA-
----GA--RLPTEAEWEQAATGMSVQ----------------GNFVDTDALHPRGAEAVDT-------GIQQ
LFGDV-WEWTGSAYLPYPGFTPWPGSL-----GEYNGKFM----NA-----QW-VLRGGSCASPAS----HL
RASYRNFFPSDARWQF--------------------------------------------------------
-------------------AGVRLAKDL
>A0A397MCB3_9GAMM/2-422 
DSVPAAVAAPQRDL-ARRFAQVRARSLQLAAPLSAED-TMLQSM-ADASPSKWHLAHTTWFF-ERFVLAG-F
ATAP-AHDPAWD-YLFNSYYKSIGPAHARPQRGLLSRPSLQQVRDYRQQVDLQVQSRLA-----AGEL----
DAQALQHLQLGLQHEQQHQELLLTDIKHAFWCNPLQP-PYREDL-R---PVAG------TATPQGWIESPER
IVTVG----------AAAWPRH--AA-FAYDNESPPHRVLLPAHALAERPVSNAEYRTFIEAGGYREPHWWL
SEGWALREAEGWQHPLYWD----------------DALQREYTLGGWRELDPHAPVCHLSYYEADACARWA-
----GA--RLPSEFEWEAAAASQPLR----------------GHFADDDHLHPQAGQGS---------GLRQ
LFGDV-WEWTASAYGAYPGFRPFDGNL-----GEYNGKFM----CG-----QW-VLRGGSCATPRD----HV
RASYRNFFMPPARWQF--------------------------------------------------------
-------------------SGLRLARDL
>A0A2G0WKT8_9PSED/4-402 
PSREPRQTAAANEL-LKRYQNVRSRTQSLAAPLSAED-MVVQSM-PDASPAKWHIAHTTWFF-ETFLLSENV
PGYE-PFDPAFG-YLFNSYYEAVGPRHPRPQRGLMTRPGVDQVMAYREHVDQHMARLLQ------NTL----
PDDLSSLIELGLAHEEQHQELLLMDILHLFSTSSLKP-AYDPAW-----PKDV------AGRRGRYKPLKGG
LTEIG----------H----KG--TD-FAFDNEGPRHTTYLQSFEISDRLVTNGEWLKFIDAGGYSQAGLWL
SEGWSIVQENAWNAPMYWQ---HDET---------HGWR-CMTLRGLEPIDPDAPVTHISYYEAAAFAQWA-
----DA--RLPTEAEWEAAVVA----------------------------------------------GLLE
QVDDVAWQWTQSSYSAYPGFRPAASAV-----GEYNGKFM----IN-----QM-VLRGGASVTSPS----HS
RATYRNFFHPEKRWVV--------------------------------------------------------
-------------------SGLRLARDS
>A0A0C4WHH3_9GAMM/4-427 
PASAQSALPSSVSL-MERFQRIRAASESICAPLQIED-YVIQSM-PDASPPKWHLAHVSWFF-EAFVLLPFL
HGYR-VLDEAYD-HLFNSYYETHGKPFPRASRGLLSRPGVAEVYRYRQHVDAAMGELLARPPVEH-------
VAEIARRLELGLQHEQQHQELLLMDILHILAQNPLRP-AYRSDL-R---PGPGQ-----LPDEPHWRDYPGG
LQQIG----------H----GG--EG-FAFDCETPRHRQFLEGFRLASRPVSCADYLAFISDGGYARPELWL
ADGWSLVQQAGWRAPLYWQ---RTD----------GRWL-EMTLGGLHPLDLQAPVCHISFYEADAYARWA-
----GA--RLPSEAEWEIAASDLPIT----------------GNFLENDHLHPVAAPQAA--------AMSQ
LYGDV-WEWTASAYRPYPGFRPLPGSL-----GEYNGKFM----CG-----QM-VLRGGCCVTPQA----HI
RATYRNFFYPAMRWQF--------------------------------------------------------
-------------------AGLRLAKEA
>A0A239EQ87_9NOCA/1-432 Hercynine oxygenase
---MSETEQLRATV-EKVLSRSRARSEALTQCVDEND-LIAQHS-PLMSPLVWDLAHIGNQE-ELWLVRD-V
GGRE-PVRQDID-ELYDAF------KHSRSSRPALPLLSPDEARAYVSTVRDKVWDVLDTSPL-GGRR----
LERDGFAFGMIAQHEQQHDETMLATHQLRVGPAVLTA-PSPPPA---------------RVPASGEVVIAGG
EFSMG----------T----SL--DP-WALDNERPAHSTYVPTFAIDVAPVTNAQYTAFIDDGGYERPELWS
ERGWAHRSAEGLSAPQFWE---RDAD---------GGWW-RRAFGVTAPVRPNQPVVHVCFFEAEAYATWA-
----GK--RLPTEAEWEKAARFDPSTASVSKYPWGDAEPT--ETHANLGQRHLEPADVGAYPDGASAQGVQQ
LIGDV-WEWTSSNFEPYQGFEAFPY-------AEYSEVFW----SG-----DYRVLRGGSFGTDEV----AC
RSTFRNWDHPIRRQIF--------------------------------------------------------
-------------------AGIRCARDV
>Q5YQ03_NOCFA/7-441 Hercynine oxygenase
PSDHSATDRLRERI-AEVLTTARARTTALTAAVGEAD-LVAQHS-PLMSPLVWDLAHIGNQE-ELWLVRD-V
GGRE-PVRADID-ELYDAF------KHARKDRPALPLLNPAEARGYVGTVREKVWDVLERSAL-RGSR----
LIEDGFAFGMIAQHEQQHDETMLATHQLRAGEPVLSA-AAPPPA---------------RVRVSGEVIVPGG
EFTMG----------T----SA--DP-WALDNERPAHPVHVPAFAIDAAPVTNEQYLAFLEDGGYERPELWS
ERGWAHRVSAGLTAPRFWE---RDGD---------GRWW-RRVFGVLSPVRPRQPVVHVCWFEAEAYARWA-
----GK--RLPTEAEWEKAARFDPATGGSRRYPWGEDEPD--DTRANLGQRHLEPAEVGAYPAGVSATGAHQ
LIGDV-WEWTSSGFDPYPGFRAFPY-------REYSEVFF----GG-----DYRVLRGGSFGTDPV----AC
RGTFRNWDHPIRRQIF--------------------------------------------------------
-------------------AGFRLARDL
>A0A2A2V5S2_9BRAD/16-417 
PSLSSESAPLAQRL-ADAYRAVRDETERRAAPLSAED-QLIQSM-PDASPAKWHRAHTTWFF-EQFLLGEHV
KGYT-PFHPDYA-YLFNSYYVSAGPRHARHQRGHLTRPTADEVTAYRRHVDAEVVKFFRTATQDT-------
LEALVPLVEVGLNHEQQHQELMYTDILHAFAQNPIPP-AYDPAWRF---PAS-------QHGPQEWVTLNEG
IHTVG----------H----GD--DS-FHFDNEKPAHRALVGPVKLAKNLVSNADWLAFIKDGGYSTATLWL
MDGFGTVSNEGWQAPGHWR---EID----------GEWK-IMTLGGLQAIDPQAPVCHVSYYEADAFARWA-
----GK--HLPTEMEWEVAAR-----------------------------------------AG----LLND
AYGIV-WQWTRSAYSPYPGYRAIEGAL-----GEYNGKFM----VN-----QL-VLRGSSLATPRG----HS
RVTYRNFFYPHHRWQF--------------------------------------------------------
-------------------TGLRLADYA
>Q218M6_RHOPB/18-418 
SRSPSESGELSQQL-LQAYRTVREETERRAAPLSPED-QVVQSM-PDASPAKWHRAHTTWFF-EQFLLGQHC
PGYA-PFHPDYA-YLFNSYYVSAGPRHARNQRGLLTRPGAAEVAAYRAHVDAAIAEFFGSADQAT-------
LSELAPLLEVGLNHEQQHQELLLTDILHAFAQNPIPP-AYQPGWRF---PD--------AQRGDDWVSLNEG
IHPIG----------H----AG--EA-FHFDNETPQHRALVGPVKISRNLVTNAEWLEFIAAGGYRTPTLWL
MDGFAAVERDGWEAPGHWR---KVD----------GSWH-IMTLGGLQPVDPDAPVCHVSYYEADAFARWR-
----GQ--HLPTEMEWEVAAR-----------------------------------------AG----ALND
AFGLV-WQWTRSAYAPYPGYRAVEGAL-----GEYNGKFM----VN-----QL-VLRGSSLATPEG----HS
RISYRNFFYPHHRWQF--------------------------------------------------------
-------------------TGLRLANYG
>U7NI80_9ALTE/22-532 
PNLAEGTPDTKRQEIARYFTDTFDTYTRLFDCLADDSGYYQKSI-PLRHPLIFYLGHTATFFVNKLVLAKIL
KER---INPNME-SIFAVGVDEM--SWDDLNDDHYDWPAVQEVLDYRAQVRQTVLELIETMPLSLPID----
WDSDWWPIVMGIEHERIHLETSSVLIRQ-HALERVQP---QPEW-A---PIRET----GEAPENELLTVPAG
KVHIG---------------KPYDDAFYGWDNEYGEHQADVAEFKASQYLVSNQEFLEFVEAGGYQQDEYWS
EEGLAWRTFAEAKHPTFWR---WQ-----------NGWQ-LRLMTEEVEMPWDWPV-EVNYHEAKAFCEWKR
EQ-TGKPIRLPTEDEWYRLCDESGVREV-GESP---------ANANLHLDHGASSCPVTRFRHG----QWFD
VVGNV-WQWTETPTYPFDNFKVHPLY------DDFTTPTF----DG-----QHNLIKGGSWISCGNEARLAS
RYAFRRHFFQHAGFRYITSEAEAVQP--NAYYESDRL-LTEYAEFHYGDSWFGVANFPKTMAELALEAMAGK
-----KTGKALDLGCACGRASFELARQF
>A0A1E7D6E2_ALTMA/1-407 
---------MQHNE-NSAFQAVRALSAQLVEPLSEAD-AQLQSM-PDASPAKWHLAHTTWFF-ETLILRQHL
PQYV-PFDDDFT-YLFNSYYNGIGEQYPRAARGLISRPSLAQIMAYRAYVDAHILQLYE-----QGLT----
P-EVASLLTLGCHHEHQHQELLLTDIKHALAQNPQAP-VYMASS-R---GDA-------MYSAHHWLRFDEG
LYTIG----------H----DT--DG-FAFDNESPAHTVYLQPFSLSSRLVTNADYQAFIEDGGYQNPLLWL
SDGWAHLQAHDVQLPLYWR---YTD----------GQYQ-HFTLSGLQPVLPHQPVTHVSYYEAEAYARWA-
----GV--RLPTEFEWEVAARAQPTR----------------GPFLSLDCLCPTAEPGP---------GLTH
MTGQC-WQWTASHYGAYPGYQPFSGPA-----GEYNGKFM----CS-----QY-VLRGGSCVTPGA----SY
RDTYRNFFYPHHAWQF--------------------------------------------------------
-------------------TGIRLAK--
>A0A0J1D8E6_9BURK/1-407 
------MGANEHRQ-AREFEQVRQRSVHLAEPLSPED-CCAQSM-PDASPVKWHLAHTTWFF-ETFILEPRE
HDWR-PFHPAFR-VLFNSYYNGVGDKHPRPQRGLLTRPAFDEVLAWRRDVDARIARLLHERPE---------
DGELAALVELGMQHEQQHQELILTDLKHLLAQNPLYP-AYLASA-L---PESC------PAGALAWLDFEGG
LAEIG----------H----RG--PG-FCFDNELPRHRQYLAPFQLASRLATNGEYLEFVEAGGYRDPSLWL
SEGWDRVCSGEIGQPFYWR---KEN----------GQWL-EFTLHGLQPLDPARPVTHVSLYEADAYARWR-
----GA--RLPTEAEWEFAARDVAIA---------------------CGDLHPRAAGSD---------GLAQ
MFGEC-WQWTSSSYAPYPGYAPAAGAL-----GEYNGKFM----IN-----QY-VLRGSSCATPHG----HA
RASYRNFFPAGSRWQF--------------------------------------------------------
-------------------TGIRLAR--
>A0A290WVY4_9BURK/1-414 
------------ML-IDYYHTVRQHSLLLAEPLSDED-CGAQSM-PDASPVKWHLAHTTWFF-ETFILESME
AAFT-PFHPAFR-VLFNSYYNGVGEKHPRAQRGVLTRPGMAQVRAYRIDVDARIARLLAGELARDERE----
--RLTMLLALGLEHEQQHQELLLTDVKHLLAQSALFP-AYLDPA-Y---RDSAVAPVQEHAQPTAWLAFDGG
LAQIG----------H----AG--DG-FCFDNELPRHPQYVAPFELAAALVTNGEFLAFIEAGGYRSAHLWL
AEGWDWVRSGQLACPLYWQ---CDDA---------GHWQ-EFTLFGLRPLDLQAPATHLSLFEADAYAHWA-
----GA--RLPTEAEWEVAAQ---------------------GVAVQVGQLHPAAGAPGT--------GLRQ
MFGRC-WQWTSSSYAPYPGYRTAPGAL-----GEYNGKFM----LN-----QY-VLRGSSCATPAG----HA
RASYRNFFPAGARWQF--------------------------------------------------------
-------------------SGIRLARQV
>A0A4R4LDU6_9ACTN/5-438 Hercynine oxygenase
ERPGAEAERLRSRI-AAELDRTRARTTLLTEVVDEDD-LMRQHS-PLMSPLVWDLAHVGNQE-ELWLVRD-V
GGRE-PVRRDID-DLYDAF------KQPRRDRPALPLLKPAEARTYLATVRDKVYDLLDGVRFTDRP-----
LVVDGFAFGMVVQHEQQHDETMLATHQLRSGPAVLDA---PPPPEP-------------RARVGGEVLVPAG
PFTMG----------T----ST--DP-WALDNERPAHTVDLPAYVIDAAPVTNGRYAEFIADGGYDDPRWWS
AAGWRHRTEAGLAAPLHWR---RDG----------DGWA-YRRFGRWSPVRADEPVVHVCFHEAEAFATWA-
----GR--RLPTEAEWEKAARWDPITGRSRRYPWGDEDPT--ADHANLGQRHLWPAPVGAYPAGASPLGAHQ
LIGDV-WEWTSTTFRGHPGFTAFPY-------REYSEVFF----GD-----DYRVLRGGSFGTDRS----AC
RGTFRNWDYPIRRQIF--------------------------------------------------------
-------------------SGFRCARDA
>R4LZ09_9ACTN/1-429 Hercynine oxygenase
-----MSDDVRLTV-AAHLQRARARTAQLTDAVDDDD-LVRQHS-PIMSPLVWDLAHVGNQE-ELWLVRD-V
GGRE-PVRRDID-ELYDAF------KHPRRDRPALPLLDPQEARRYIAQVRDKALDVLDRVRLDERRL----
V-ADGFAFGMIVQHEQQHDETMLATHQLRTGDPVLSA---DPPPAA-------------TAAVSGEVFIPGG
PFTMG----------T----DT--EP-WALDNERPAHTVHVPAFFIDAAPVTNAQYADFIAAGGYDDPRWWS
PRGWAHRQEAGLTAPMHWH---RDG----------DGWA-YTRFGRTTRVIRDEPVVHVCFFEAQAYAAWA-
----GR--RLPTEAEWEKAARFDPVTGRSRRFPWGDEAPS--SRHANLGQRHLAPAPVGAYPQGASPSGVHQ
LIGDV-WEWVDSGFHGYPGFQVFPY-------AEYSQVFF----GG-----DYKVLRGGSFGTDAA----AC
RGTFRNWDHPIRRQIF--------------------------------------------------------
-------------------SGFRCARDA
>A0A1I7HZE5_9PROT/12-524 
PVLGGDDVEAKREELRAYFHTTLDWYEQLFKTLRSNEAYYIKPI-SLRHPLIFYLGHTATFFINKLILAGVL
TER---INPRLE-SIFAVGVDEM--SWDDLDATHYDWPSVEEVMAYRRTMRQKIDALISSLPLTLPIT----
WESPWWAIVMGVEHERIHLETSSVLIRQ-HKLDYVQP---HSAW-Q---PCHES----GSAPENGMVTVPAG
KVVLG---------------KRKIDLVYGWDNEYGHHEAELPDFQASRYLVSNQEFLVFVEAQGYKTDDYWE
EEGLAWRKFSGAAHPTFWV---QQR----------DQWL-LRLMTEEAPMPWNWPV-EVNYHEAKAFCNWKA
KT-TGQPVRLPTEDEWYRLYDVAGLSEIPRTEQ---------AQGNIHLDYYASSCPVNKFQQG----EFFD
VVGNV-WQWTETPMHPFPGFEVHPLY------DDFTTPTF----DD-----QHNLIKGGSWIACGNESIRTS
RYAFRRHFFQHAGFRYVISAASAEHH--SSHYETDKL-LSEYAEFHYGDTYFDVPNFPTALVKLAIAAMGNR
-----PARKALDLGCASGRATFELARHF
>A0A1I2ZTK6_9PROT/41-553 
PTLAGSDAAAKREEIRRYFHATLDCYEQLFQTLQDDEAYLKKPI-SLRHPLIFYLGHTSTFFTNKLVLAGLI
TER---INPRLE-SMFAVGVDEM--SWDDLDTTHYDWPSVEEVRAYRAKVRLIVDKLITDMPLTLPIG----
WDSPWWTIMMGIEHERIHLETSSVLIRQ-HALEYVRP---HPAW-E---PYKGS----GEALENQLIDVPEG
VVQLG---------------KTKTDPTYGWDNEFGKRVAQVAAFQAAKYLVSNGEFLAFVQAGGYGNESFWE
EEGRAWRCYTRTDYPVFWT---RKG----------SDWY-LRLMTMEIPMPWDWPV-EVNYHEAKAFCNWKA
AL-SGQPYRLPTEDEWYRLYDVAGLSELPHMES---------APANIHLDHWASSCPVNEFAHG----EFYD
VVGNV-WQWTETPIYPFEGFDIHPHY------DDFTTPTF----DG-----RHNLIKGGSWISCGNESLKSA
RYAFRRHFFQHAGFRYIVAAAPAVQQ--GSHYETDKL-LSEYAEFHYGDTYFDVPNFPKALAELAIAAMKDK
-----PAHRALDLGCASGRATFELARHF
>A0A4P7Z7A8_9PROT/39-467 
APSAGLSAAERRQTLATRFQKARARTAELVATLSPED-LMVQTV-ADGAPAKWHLAHTSWLF-EVAVLIPFS
PGYR-PADPAFL-DLFAARTDG-GPAPPR----VLSRPTAAEIMRHRDQINGAVLHLIDALDGSL-------
WEAAESALMMAIAHERRHQERMLLHIKHALWCNPLRP-AYEEAPDH---PHL-------GAPPDGWLEQPGG
LVEVG---------------RP--APLPGFDHEGPRHRVWLEPYRLAARPVTCGEFLAFIDAGGYSDRSLWL
TDGWETAHAEGWSAPLYWE---RGGFGSG------ARWQ-VFTLYGMQPLDPDEPVCHVSWYEADAYARWA-
----GK--RLPREAEWEAVAAGCDSM----------------GNLLGTGHRHPRAGTCHGT-------GPWQ
MCGDV-WEWTGDAFLTYPGYRRPHGAEKAVPDEAVNGRLA----AN-----RM-VLRGGSCLTPFD----RA
GPWTRHYLRPETRLSV--------------------------------------------------------
-------------------SGFRLAEDA
>A0A560IPN8_9PROT/21-440 
QPPLSLPGRHRPADAQARYRAVRQETLARTQGLTAED-QTLQSM-PDASPTKWHLAHTTWFF-ETFLLTALV
PGYQ-PFDPSFR-YLFNSYYEGVGERWPRPARGLLSRPTVAQVLDYRAHVDRAMDAWLA------GGV----
DARAAALLELGLQHEQQHQELIITDIKHALLLHPFPTGVFPPPA-T---PAL-------TAGEVVWRGVPAG
LYAIG----------A----TG--QEDFIFDNESPRHKVWLEAFEIADRVVTNAEYLDFIADGGYRRPDLWL
SDGWATVQAQGWQAPLYWQ---RGDE---------GEWQ-VKTLSGVRAIDPNEPVCHVSQYEADAYAKWAE
ARWPGA--RLPTEAEWEIAA----------------------------GEPGQRPGDDGSFHAH----TATG
FYGDV-WEWTASAYTGYPGYRPPDGAI-----GEYNGKFM----SG-----QM-VLRGGSRATPAG----HV
RKTYRNFFPPAARWQF--------------------------------------------------------
-------------------SGIRLARTT
>M2PXM6_9PSEU/53-604 
SLPLPDLSVCSREEVLDYFDNAWTLHEVLFAGLKGAEAFYRPPDHNLRHPMVFYYGHTTALYVNKLRVSGLL
DAP---IDAYLE-HVLEMGVDEN--SWDDMSKNDMVWPSVSEVKDYRAEVYRTVVGIIETTPFAPDLGRPVT
MDDQAWALLLAIEHDRIHLETSSVLIREMRSNLVERP-AAWPAPSPLRRTTETGKPEPGSVPANGTVTVPGR
TARLG---------------KPLSFPSYGWDSAYGSRRRELPDFEAARCLVSNGEFHAFVADGGYRRPELWS
AEGEAWRRFRNTKWPRFWVPTGPTGL---------HAFR-LRTLFDEIDMPWDWPVV-VNFHEAKAFAAWRS
EK-EGRDYRLPTEAEYFLLRDLPERPGVADDVVMRLDGAQLREEGINLGLAWGSEGPVDHSPTTSQ--GLHD
AGGNL-WAWSEDTFNPLEGFTPHPYY------EDFSVPSF----GG-----QHALILGGAYISSGELGSIWA
RHFYRPHFLQQAGIRLVVAPESTVDGAARAELDRALLGQYGTAEQAFGGTGHPLAATAGHPDRLARRFVEAA
DEAGIELRRVADLATATGGLAFSLAGRP
>A0A292Z506_9PSEU/5-443 Hercynine oxygenase
PAPAALDEETVRSRVAELLGRSRARSTALTDAVDESD-LVAQHS-PLMSPLVWDLAHIGSQE-ELWLVRD-V
GGRE-PLRPEID-GLYDAF------QHSRASRVDLPLLTPAEARTYIAEVRDKALDALDRTPL-RGRR----
LVDNGFAFGMIVQHEQQHDETMLATHQLRLGAPVLHA-AAPPAGVD---P---------VRLGPREVLVPGG
RFVLG----------T----SA--EP-WALDNERPAHPVDLPAFVIDTYPVTNGEYVAFVEAGGYDDPRWWS
EAGWAHRVDAGLVAPQFWE---RDTS---------GTWW-RRRFGVVEAVPADEPVVHVCFHEAAAYAAWA-
----GK--RLPTEAEWEKAARHDPATGRSRRFPWGDDDPT--PAHANLGQRHLRPAPVGAYPAGASAHGVHQ
LMGDV-WEWCDTGFHPYPGFEMFPY-------PEYSQVFF----GG-----DYKILRGGSFGTDPS----AV
RATFRNWDHPIRRQIF--------------------------------------------------------
-------------------SGFRCARDA
>A0A1V1UVW4_9CAUL/1-402 
MNARFEPDAGTAAD-VARYRAVRAAMVELAVGLSVED-LSAQSM-PDCSPGKWHLAHTSWFF-EAMILGD-D
PAYR-PVDPRFQ-QLFNSYYEALGERVARHQRGLMTRPSVEEVLAYRREVDRRMIDWLA-----QAPS----
GGQHRYLLELGLHHDQQHQELFLMDILNLMSRSPLDPAAYEVEP-R---VEFL------QPARGGVVAFAGG
LVTIG----------H----DG--AG-FAFDNEGPAHKVWLEPFALAADLVTNGDWLRFMADDGYGRADLWL
SDGWAVVKAEGWTAPHYWR---RDG----------DGWT-AMGLTGRAPVDPAAPVRHISFYEADAYARWA-
----GK--RLPTEAEWEHAATTQAH-------------------------------------------AFSN
LSGEV-WQWTASAYAPYPGFQPTPGTA-----AEYNGKFM----AN-----QM-VLRGGAFATPPG----HA
RPTYRNFYYPQQRWAF--------------------------------------------------------
-------------------MGLRLAEDA
>A0A2D2AUX7_9CAUL/1-415 
----MALDIGDRERWITAIAAVRGRTLALAAPLSAED-LQAQAM-PDASPGKWHLAHTTWFF-DEFLLGP--
AGMA-PARPASAGFLFNSYYEAVGARQPRPERGLITRPALSEVTAWRRRVDAGLERYVREADAVA-------
FAAAAPLIELGLAHEEQHQELFLMDILALLARHPDGP-AYRADL-K---SAAGP-----KARAAGWIEHGGG
LMEIG----------A----VA--DGAFAFDNEGPRHKVWLEPFALADRLVTNGEWAAFMEDGGYRDPALWL
SEGWETVRTQGWDAPEYWR---EEGV--------------SVTLAGREAVDPDAPVQHVSFYEADAFARWA-
----GA--RLPTEAEWETLAADRPAT----------------GNFMDADVLRPRPSGAGD-----------Q
LFGDL-WEWTASAYGPYPGFRPAQGAL-----GEYNGKFM----AR-----QF-VLRGGCCATPPG----HA
RAAYRNFYHPHQRWMF--------------------------------------------------------
-------------------SGLRLAKDI
>A0A2U8WRU4_9RHIZ/1-385 
---------------MAAFRHVRDETERRAAPLSPED-QQIQSM-ADASPTKWHRAHTTWFF-EQFLLTAMV
PGYT-VFDERFF-YLFNSYYVQAGPRAPRISRGLVTRPTCDEVAGYRAHVDRAVADLIAGASEGR-------
LPEIVATLEIGLHHEQQHQELMLTDILHAFAQNPLLP-AYDEGWRW---PA--------LSQRSGRVALDGG
VTQMG----------H----AG--AG-FHFDNEEPRHDVLLRPVTLERGLVTNGEWLEFMQDGGYAKPELWL
SDGFVAAQEQGWEAPGYWR---RAD----------GVWS-SMTLAGLRPVDPALPVTHVSYYEADAFARWA-
----GR--DLPTEAEWEAAS-------------------------------------------G----SLDA
AFGHV-WQWTRSAYGAYPGYRPLPGAL-----GEYNGKFM----VS-----QF-VLRGASVATPQG----HS
RPTYRNFFYPHQRWQF--------------------------------------------------------
-------------------TGLRLSQYG
>A0A1W6RPJ3_9RHIZ/18-419 
PPPPLDARPIDRDAWIAAFRTVREETERRAAPLSPED-QQIQSM-EDASPTKWHRAHTTWFF-EQFLLGDHQ
PGYR-LFDERLH-YLFNSYYVQAGPRQPRFMRGMITRPTAQETAAYRAHVDRAVSVWLREAADEA-------
LARALPILEIGLYHEQQHQELMLTDILHAFAQNPLDP-VYDARWSL---PA--------AQASAGQSALKRG
ITQIG----------Y----DG--HG-FAFDNESPRHDVLMLEARIDRGLVTNRDWLAFMEDGGYARPELWL
NDGWVALQREGWEAPGYWR---REA----------DGWS-TMSLAGRKPVDPAAPVAHVSYYEADAYARWA-
----GR--DLPTEAEWEVAAR-----------------------------------------DG----LIDD
AFGLV-WQWTRSAYGPYPGYRPVPGAL-----GEYNGKFM----SN-----QY-VLRGSSVATAQG----HA
RVGYRNFFYPHQRWQF--------------------------------------------------------
-------------------TGLRLADAG
>F7T4H5_9BURK/9-437 
HPANGPYAAGQAGQ-HDRYDAVRATTTALAAPLSPED-CQVQSM-PDCSPVKWHLAHTTWFF-ETFLLTHFH
PPYA-AFHPQYR-MLFNSYYNAIGAKHPRPQRGLLTRPPLADVMRYREHVDQAMHDLISRLGGN--------
DPAFDALLELGLNHEQQHQELILTDLKHLLSANPLKP-AYVASG-S---PALP------PGTPAGWTRYNGG
VVRIG----------H----DG--QD-FAFDNEGPAHDVLLAPFHLADRLVTQHEYLAFIRDGGYKRPELWL
SLGWERVCAEGWRAPLYWE---GQR----------DDWR-VFTLRGMQELELQAPVTHISYYEADAYARWA-
----RV--RLPREAEWEHAARQLPDGAWSNR-----------ANLLENGHLDPRPAPARQ--GG----GPAQ
LFGDA-WEWTASAYDAYPGFKPDAGAV-----GEYNGKFM----CN-----QF-VLRGGSCATPRG----HI
RPSYRNFFPPEARWQF--------------------------------------------------------
-------------------SGIRLARDA
>A0A261TEU6_9BORD/18-452 
ALTHPPAMRAGPPTLAERFHAVRTQSRTLAAPLSPED-CQAQSM-PDCSPVKWHLAHTTWFF-ETFVLARYY
PAHQ-PVNPQYR-VLFNSYYHGVGERHPRPQRGLLTRPTLAEVLEYRERVDASVQALLR--KLGDDPD----
GEPARALIELGLHHEQQHQELILTDVKHLLSCNPIAP-AYADAP-L---PALP------PGTPAGWTRYDGG
VVRIG----------H----QG--DG-FAFDNESPAHDVLLQPFHLANRLVTQGEYLAFMLDGGYRRPELWL
SLGWDQVSAQGWRAPMYWQ---GQK----------DEWQ-AFTLHGMQPLDLQAPVVHVSYFEADAYARWA-
----RV--RLPREAEWEYATRSRQGAAPGADAH---------ANFLESGRLGPCPAPRPNA-AG----GPVQ
LYGDA-WEWTSSSYDAYPGFTAPAGAV-----GEYNGKFM----CN-----QY-VLRGGSCATPES----HI
RASYRNFFPADARWQF--------------------------------------------------------
-------------------SGIRLARDA
>A0A0Q8E9D3_9GAMM/1-404 
-------------M-AARFRGVRQRTLDLCAGLSAED-LQIQSM-ADASPGKWHLAHTSWFF-EQFVLAR-D
PAWK-PRNEAWL-YLFNSYYQSVGPMHARPQRGLLSRPSLEEVFAYRRYVDDAVGKLLASHA----------
DAELTTLVELGLQHEQQHQELLLTDIKHAFSCNPLRP-AYHAAP-A---ADAG------APVPQRFIPGREG
IVETG----------N----DA--EG-FAFDNETPRHRELLHPHALANRLVTNAEYLAFVREGGYREPGLWL
SDGWATVQREGWQHPLYWD----------------DDLAREFTLAGMQALSPHAPVCHLSYYEADAFARWA-
----GA--RLPTEAEWESAASRVGVA----------------GNLQETGRLHPAPAEPGD--------DMLQ
MYGDV-WEWTASPYISYPGFRPLPGSL-----GEYNGKFM----CG-----QW-VLRGGSCATPRD----HV
RASYRNFFPPHARWQF--------------------------------------------------------
-------------------SGLRLGQDR
>A0A370WYD5_9GAMM/1-416 
-MNVPAFAPYTEDA-VTRFMRIRRQTLALCAGLSGED-LQVQSM-PEASPGKWHLAHTTWFF-EQFVLGC-D
PAYR-SADPAWD-YLFNSYYESVGPMHARPKRGLLTRPTLDDIRDYRSRIDEAVGELLV-----RGVD----
-QPLAARIELGLQHEQQHQELLLTDIKHAFWCNPLQP-AYHHAS-S---PNES------RSAPMRFVPGRQG
PMDIG----------H----HG--DG-FAYDNETPRHTTWLSSHALANRLVTNDEYLAFIRDGGYRDAGLWL
SDGWVRVQRDGWERPLYWQ----------------QDLTSEFTLAGIQPLDPHAPVCHISYFEADAFARWA-
----GA--RLPTEAEWEDAAARLPLH----------------GNFQDNLRLHPIAMPSGD--------GLLQ
MYGDA-WEWTASPYVSYPGFKPLPGAL-----GEYNGKFM----NG-----QW-VLRGGSCATPRD----HI
RASYRNFFPPHARWQF--------------------------------------------------------
-------------------AGIRLGQDR
>A0A547PDS2_9SPHN/1-411 
-MPQSKPVIDEGASLSRQFLETRTLTEALTASLSDAD-ATIQSM-EDASPAKWHLAHTTWFW-ETFLLRDYA
PGYR-LYNERWP-YLFNSYYEAEGDRIGRFSRGLLSRPTLTEVLEWRAHVTDAMSALLD-------------
EPAHADLIALGIAHEQQHTELLLTDIKHALFQNPLGPAMFGGSP-E---PAMSP-----GAQPLGWHQHPGG
VIMIG----------A----QA--DG-FAFDNEGPQHRALIEPFALARRLVSNRQWSEFIADGGYSTASLWL
SDGWAWVKEHGISAPLYWR---DDQ---------------AFTHQGWHPRDPDAPVTHISYYEADAFATWA-
----GA--RLPTEFEWEAIGQSHSAA----------------AGNQLDGAAAPAPC------------GGEA
LFGDC-WQFTRSAYLPYPRFTPAAGAV-----GEYNGKFM----SG-----QF-VLKGASCATVRG----HS
RASYRNFFYPHQRWQF--------------------------------------------------------
-------------------TGLRLARDV
>A0A0T2QDT3_9SPHN/2-411 
PEAQRQRTTAAPDL-ASRYAATRRLSEALVESLSEAD-ATIQSM-PDASPAKWHLAHTTWFF-ETFLLRDRL
PDYR-LFDGRWP-FLFNSYYESEGDRLMRPRRGMLTRPTLREILDWRVHVDEAMRALLD-------------
DPAHASLIELGIAHEQQHQELLLTDIKHALFQNPLGP-AMWDAREA---GAQT------GDAAPDWYEHPGG
IALIG----------H----GG--ES-FAFDNEGPPHRVLLEPFALAGRLVTNGEWQAFIDDAGYRTASLWL
SDGWDWVRREQIVAPLYWR---DGE---------------HFTHAGFQPRRSEAPVCHISYYEADAFASWA-
----GA--RLPTEFEWEAIGLSHD------------------PTGGNQIDEASPPLPT----------GSTG
LFGDC-WQFTRSAYLPYPRFAPAEGAV-----GEYNGKFM----SG-----QW-VLKGASCATVRG----HS
RASYRNFFYPQQRWQF--------------------------------------------------------
-------------------TGLRLAKDL
>A0A2R7PYK3_9GAMM/21-535 
PLLTGSDPEQKRRELLAYFCQTFDLYDSLFDCLADERAWFNKAI-PLRHPLIFYYGHTAAFFINKLLAARLI
DQR---LDARIE-AMVAIGVDEM--SWDDLDETHYDWPKVSELRSYRAKVRTLVCDFIRQMPLTLPID----
WQSPAWVILMGIEHERIHLETSSVLIRQ-LPLAWVRP---QPYW-P---ACTEARHRIDQVPANSLLPVAGG
KVRLG---------------KQ--DATYGWDNEYGERQIELAPFQASRMLVSNAEYLAFVQAGGYCQQQWWD
EEGWSWCQYAKAQMPTFWVGAPAEP----------GQLQ-LRLMTEQVAMPWDWPA-EVNQLEAAAFCRWKA
AR-TGLPIQLPSEAEWMLLREQVPGDQPDWTE----------APGNINLARFASSCPVDACPQG----EFFD
LVGNV-WQWTSTAIDGFDGFKIHPLY------DDFSTPTF----DG-----KHTLIKGGSWISTGNEALKSS
RYAFRRHFFQHAGFRYLVSRYQEPVI--VNPYETDTL-IAQYLDFQYGPNHFGIANYAKTLADLAGELCS--
-----NHQRALDIGSATGRASFELARHF
>A0A231MYU3_9GAMM/12-526 
ILLTGDSVERKREELRTYFHRTFSLYESLFDCINSDDAYYLRPE-PLRHPLIFYFGHTAVFFINKLVLGKYL
DRR---LDERLE-SMFAIGVDEM--SWDDLNEANYDWPSVTDTRAYRRRVRERVDAFIGEMPLGLPIT----
PDSPAWIVLMGIEHERIHLETSSVIMRM-LPLDWLQP---HPFWSS---ACPES----GPAPENGLLPVAGD
TLTLG---------------KPDSAASYGWDNEYGRKTVAVRPFRVSRFLVSNGEYLQFMQAGGYRSPEYWT
EEGRQWLAFSRAAMPRFWC---ERH----------GEYY-QRNLLQEVPLPLDWPV-EVNYLEAKAFCNWKA
AQ-AGTHVRLPTEAEWTLLRNRLDTDQPGWGR----------APGNINLEYFASSCPVDRFAVD----GIHD
LVGNV-WQWTETPIDGFPGFEVHPLY------DDFSTPTF----DN-----RHNLFKGGSWISTGNEATRYS
RYAFRRHFFQHAGFRYIESDYAEVPVEPVNTYETDEL-VAQYLEFHYGAEYFGVANYPVACVRTLLARLPGL
-----DKGRALDLGCSVGRASFELALHF
>V2TYT6_9GAMM/35-543 
PRLDVTQADTLRATLKQYFLQTFDCYESLFSCLNGDEAFYHKPI-VLRHPLIFYYGHTATFFINKLLLSKLI
EQR---INPHFE-SIFAVGVDEM--SWDDLDDSRYDWPTPAQVKHYRDQVRATGLEIIEKAPLSTPID----
WQHSWWSILMGIEHERIHLETSSVLIRQ-HALDYVQT---QPPW-R---PNILT----NTAPENALLPVAAG
RVQLG---------------KERHDPVYGWDNEYGQYQAEVAAFAASRYLVSNQEFLAFVEDAGYQNANYWE
DEGWQWRSFAQAKYPTFWR---KHG----------PDWS-LRLLTEEVPMPWDWPA-EVNYHEAKAFCHWKA
KQ-TGQPVRLPTEEEWYRLVQLAGVNEPS-------------APANLALAYGASSCPVNTFPHG----DFYD
LRGNV-WQWTETPIYPFPGFVVHPIY------DDFSTPTF----DG-----RHNLLKGGSWISAGNEAELAS
RYAFRRHFFQHAGFRYVVSDQEPLAI--QSQYETDRL-VSEYLEFQYGREYFGVANFAQTLVQLALTQLADR
-----PRRKALDIGCATGRASFELARYF
>A0A4Y7XFR9_9GAMM/57-573 
PNLRDSDQVTMRRTLRHYFLDTFNTYESLFDCLASENAFYIKPI-SLRHPLIFYYGHTATFFINKLLLARLI
NER---VDQRME-SIFAVGVDEM--SWDDLNEANYDWPSVHDVKAYRDKVRTLVLDLIDHAPLHMPID----
WENPWWAIIMGIEHERIHLETSSVLIRQ-HDLSMVKS---SPNW-Q---PNNYS----GVAPENQLIHVAAG
KVRLA---------------KDKTSPFYGWDNEYGVHDAEITAFEASKFLVSNQEFLEFVEAKGYQTAEYWT
EEGQGWLQFTNAEHPTFWR---KAP----------DGWY-LRLMTEEVCMPWDWPV-EVNYHEAKAFCNWKK
QQ-TGHAVRLPTEDEWYRLYDIASIRDV-GAAP---------AQANIHLDHGASSCPVNQFAQG----EFYD
VVGNV-WQWTETPIYPFEGFEVHPIY------DDFSTPTF----DE-----RHNLIKGGSWISTGNESLHSA
RYAFRRHFFQHAGFRYVISGEINSVP--ASHYETDKL-MSEYAEFHYGDEYFGVPNFSKALVELAVATLTKH
QLDGLPKHTALDLGCASGRATFELARYF
>A0A1G1T4P4_9BACT/3-433 
STLEIQSPPRIAPSWLARYQAVRTQSTALCAPLLPED-TVVQPM-IDVSPPKWHLAHTTWFW-ETFLLREYA
PGYQ-VFHPEYA-FLFNSYYNSLGSRVNRADRGTLSRPALADVLAYRNHVDAALAALLA----KPHEL----
PATFFELLELGLQHEQQHQELLATDIKYILSTSPLAP-AYLPISEKANVQAAA------PVASATWLPVPGG
ICRVG----------F----QE--EG-FCFDNELPAHDVLVAPFELQNRLVTNADYLAFMEAGGYRDFRFWM
GEGWDLLQAEGWTAPLYWV---QKA----------GGWY-RFTHHGLLAVDPAAPVTHVSFYEADAYANWA-
----GA--RLPTEAEWETAACHFNATPEG-------------GTWLESNALDPQPLPADADPS-----ACHQ
LLGDC-WEWTYSAYHAYPGYSRAAGAL-----GEYNGKFM----VN-----QL-VLRGGSCATPEN----HI
RISYRNFFHADKRWQF--------------------------------------------------------
-------------------TGIRLAR--
>A0A1N6X753_9BACT/1-421 
--MNILTASINKTT-LERFNQIRTQTEKICAPLEPED-TVVQPM-VDVSPPKWHMAHSTWFF-EQFVLGPYL
KNYR-VFHPSYA-FLFNSYYNTVGNRVQRAERSTLTRPPLRDVYAYRRHVNEHMGELLN--TLSDEKL----
E-ELLPVLELGLQHEQQHQELLITDIKYILSTNALLP-AYHEAVSV---PQAS------NPGEAAFLEVPGG
IYRIG----------F----QG--EG-FSFDNELGVHEVLLADFQIMNRLVTNREYLEFMQEDGYSDFRFWL
DEGLAMVRRDNLKAPLYWL---EQD----------GDWY-QFTMHGLEKLDLHKPVSHISFYEAQAYATWA-
----GK--RLLTEFEWEAASQVYPPVE---------------GNFQETGMYEPKAATSGT--------GMQQ
LYGDT-WEWTYSAYHPYPGFSTAPGAL-----GEYNGKFM----VN-----QM-VLRGGSCATPER----HI
RTTYRNFFHPDKRWQF--------------------------------------------------------
-------------------SGIRLAQ--
>A0A246NKE3_9GAMM/17-531 
VRLSGSSSDAKRAELLAYFTQTWELYESLFDCLADERAYFNKAI-TLRHPLIFYFGHTATFYINKLMAGGYL
QQR---INDRIE-AMMAIGVDEM--SWDDLDDSHYSWPDVAEVRDYRGKVKTVVSEFIRTMPLELPID----
WDSPAWVILMGIEHERIHLETSSVLIRQ-LPLEWVKP---QPHW-P---ACPQARHNRASVPANTLVAMPGG
RVTQG---------------KT--DDTYGWDNEYGSLSTELKPFKASKMLVSNAEFFHFIAANGYNERRWWD
DEGWGWREFAQAQMPTFWVGDIAQP----------DDLR-LRLMTEEVAMPWDWPA-EVNQLEAAAFCRWLA
EE-SGKAIQLPCEAEWMQLREQVAGDQPDWID----------APGNINLARWASSCPVDHFAQG----DFFD
IVGNV-WQWTTTPTNGFEGFRVHPLY------DDFSTPTF----DG-----KHALIKGGSWISTGNEALKSS
RYAFRRHFFQHAGFRYVVSSHQESMA--LNPYETDSM-VSQYLDFQYGPGYYGVPNYAAALVDIVLPHCA--
-----QRGHALDIGCATGRASFELARHF
>A0A3N1W290_9GAMM/18-532 
LLLNGGDPEQKRQQLLAYFRQTWELYERLFDCLADERAYYNKAI-PLRHPLIFYFGHTATFYINKLMAGRLI
DAR---IDDRIE-AMMAIGVDEM--SWDDLDNSHYSWPSVSELRDYRGKVRAHVEQFIAEMPLSLPIG----
WDSPAWVILMGIEHERIHLETSSVLMRQ-LPIGWVNP---QPHW-P---ACTEARHDRLTVPENALIAVAGG
HVTQG---------------KT--DPTYGWDNEYGTHVSEVKPFRASKMLVSNAEFFTFVAAGGYQQSRWWD
EEGQGWRDFSKATMPTFWVGSAERP----------DTLR-LRLMTEEVPMPWDWPA-EVNQLEAAAFCRWKA
EE-TGKSIQLPAESEWMLLREQVAGDQPDWES----------TPGNINLAYWASSCPVDRFSQG----EFFD
LIGNV-WQWTTTPINGFEGFRVHPLY------DDFSTPTF----DG-----KHALIKGGSWISTGNEALKSA
RYAFRRHFFQHAGFRYVVSSHQETMA--QNPYETDTM-VSQYLDFQYGPEYFGVANYAHALVEIACGLTD--
-----KRQRALDLGCATGRASFELARHF
>A0A5B1LK24_9ACTN/5-436 
TAVTAGAGWDPTTL-QSRYDEVRSYTETLAAPLSPED-QTVQSM-ADVSPTKWHRAHVTWFF-ETFVLADNE
ASFA-PFQDKYW-FLFNSYYEAVGPRYSRADRGLISRPGAHDVGVYRSNVDDRMHDLIA--RLDDGAL----
T-KLASTIELGFHHEQQHQELLLMDIKHVLSRNPLQP-VYAGRP-T---AES-------TPDRLGWVEVDGG
LVEVG----------H----EGSRDGGFCFDNELPRHEQWLRPFRIADRLITNGEWWEFMADGGYRRHEHWL
SDGWAKVTTEGWEAPFYWT---EVD----------GVWF-EHTLHGTWPVNPGLPVSHVSFYEAEAYASWA-
----GK--RLPTEAEWEHAARGATASTTDVPT----------GNLANTTSFHPEAAPPA---SG----GLRQ
MFGDC-WEWTSSAYHPYPGFHPPAGAI-----GEYNGKFM----SN-----QM-VLKGGCALTPAG----HT
RASYRNFFPHQSRWAL--------------------------------------------------------
-------------------SGVRLADDG
>A0A4R2CFH8_9ACTN/3-438 Hercynine oxygenase
HQLSDLTAEELRSFVAAQLERSRGRTVQLTDAVDTDD-LVRQHS-RLMSPLVWDYAHIGNQE-ELWLVRD-V
GGRE-PVRQDID-ELYDAF------MHARADRPSLPLLGPTETREYVVEVRDKVLDVLDHVKFSGGRE----
LVDNAFAFGMIVQHEQQHDETMLATHQLRTGAPVLDA-PAPPAG---------------RRLARSEVLVPGG
VFEMG----------T----SI--EP-WALDNERPAHAVHVAPYVIDTAPVSNGDYLKFVTGGGYQDAQWWS
EAGWAHVQKASLVAPRFWE---LVD----------GNWL-RTRFGHRELLPLDEPVMHVCFYEAEAYARWA-
----GK--RLPTEEEWEMAARFDPATGRTRRFPWGDESPG--PQHANLGQRHLRPAPIGAYPAGASPLGVEQ
LIGDV-WEWTSSDFRPYPGFRAFPY-------DEYSLVFF----GS-----DYKMLRGGSFGTDEV----VA
RGTFRNWDYPIRRQIF--------------------------------------------------------
-------------------AGFRCARDP
>A0A4R7YK28_9GAMM/23-534 
VMLAGNDPEATRREIETCFTATFDRYESLFTTLTSEEAYVRKPI-ALRHPLIFYLGHTATFFVNKLVLAKLL
PAR---IDPNME-SIFAVGVDEM--SWDDLNEAHYSWPSVSEVMEYRAKVRAAVLNLIRELPVSLPIG----
WDSPFWPIVMGIEHERIHLETSSVLIRQ-QSLDLVTP---QPAW-E---PIRTT----GEPPENTLITVPQG
EVVLG---------------KSFDDPWYGWDNEYGHHRADVEEFKASQFLVSNNEFLEFVEAGGYLTDAFWS
EEGLGWRNFAKATHPTFWV---WK-----------NEWL-LRLMTEEVEMPWDWPV-EVNFHEAKAFCNWKS
QQ-TGQPVRMPTEDEWHRLVEEAGVSEIESNKP---------ANANLHLDHGASSCPVTRFQHG----QWFD
VVGNV-WQWMETPTYPFPGFDVHPLY------DDFTTPTF----DN-----QHNLIKGGSWISCGNETRLSA
RYAFRRHFFQHAGFRYVVSDAEVKLP--SAYYESNAR-MAEYAEFHYGDEWFGVANFPQVLANKALASMAGR
-----QKKRALDLGCASGRSSFELAREF
>A0A5C1A3K4_9GAMM/3-445 
HYPVENLDATHAKEWLRCFQRVRQASETLCAPLHTED-YMVQTM-PDVSPPKWHLAHVSWFF-EAFLLKPFL
QDYQ-TPNDAYD-FLFNSYYETHGEPFPKPLRGTISRPTVAEMYQFRAHIDAEMARLLNDPPLDR-------
LGEILSRVEIGLHHEQQHQELLVMDIKHILSCNPLHP-VYRDDVRE---RLLEITETRQVQTAQQWHRYTAG
VRLIGKDYSVAEGPQR----DA--GG-FVFDSETPRHRQYVAEFELADRPVTNGEFIDFIEDGGYQRTELWL
SDGWHHIHETGWQAPEYWQ---LVD----------GRWH-QMTLGGLVPVDPDAPVCHVSFYEADAFARWA-
----GA--RLPTEAEWEVAAAELPVA----------------GNFVENDWLQPVASDSEGHE------GPHQ
MFGDV-WEWTGSAFRPYPGFKPLEGSL-----GEYNGKFM----SG-----QM-VLRGGCCATPGD----HI
RDTYRNFFPPQARWAF--------------------------------------------------------
-------------------SGFRLARDA
>A0A0M6ZW58_9RHOB/2-421 
TYLDERSEPSSASELLDLFYATRTQTEKLTAPLNDED-LGLQSM-EDASPPKWHLAHTTWFF-EEFILKPFL
PGYQ-PKDNRFA-VLFNSYYVQAGPRHTRSRRGLLSRPTVTEVLSYRAHVEDALRDGLSRGGFTLD------
PDRLDALVTLGCHHEMQHQELLITDLLHALSFNPLLP-AYIPSQ-P---GAVT------AIREQDWTLHAGG
LVEIG----------H----DG--DG-FAYDCEGPRHKVWLEPYKLADRLVTNGDWIAFMNDGGYETQTLWL
MEGWAVREKNGWDSPLYWW---QQD----------GQWW-TYTLQGPRPVDLSAPVVHVSFYEADAFARWS-
----GR--RLPTEAEWEAAAEATEIE----------------GNFLENGTHIPQG-------------RHAS
LWGDV-WQWTSSAFSPYPGFSPPDGAI-----GEYNGKFM----VN-----QM-VLRGGSCATPKL----QM
RSSYRTFFYPQQRWQM--------------------------------------------------------
-------------------LGLRLAADQ
>A4WZG6_RHOS5/2-415 
PQLKPAAPPSRSHA-QDLFARTRAMTARLAQPLAPED-MMLQSM-EDASPAKWHLAHTTWFF-EEFILKPHA
QGYR-SPDERFA-FLFNSYYVQAGPRHARARRGLVSRPGVQAVLDYRAHVDEALGTLLEHSD----------
NPDVAALAELGCHHEMQHQELLVTDLLHAFSYNPLLP-AYRDPE-P---VGVT------EERPLRFARHEGG
LVEVG----------H----EG--GG-FSYDCEGPRHRVWLDPYEIAERPVTNREWIAFMEAGGYGEQTLWL
MEGWAVRERERWDAPLYWW---QQD----------GVWW-TYTLRGPQPVNLDAPVCHVSYYEAEAFARWA-
----GG--RLPSEAEWEVAFRDRPIA----------------GNFLEQGALRPLP-------GG----GP--
-WGDV-WEWTASSFSPYPGFRPPEGAI-----GEYNGKFM----VN-----QY-VLRGGSCATPAA----QM
RPTYRNFFYPHQRWQM--------------------------------------------------------
-------------------MGLRLARDV
>A0A4P9IZY8_9GAMM/1-422 
MRESVTNDTNQNEL-VKRFCSVRDESLAIIEPLTVED-CQLQAM-ADASPTKWHLAHTTWFF-ETFLLSVHC
KQYA-VFNPHYK-MLFNSYYNGIGEQFKRANRGSLSRPGLDEVLAYREHVDSRVIELLK-----TDVD----
P-HIKDIIELGLHHEQQHQELMLMDIKYNFSVNPIFP-QYKTSL-L---NSQKKSA---DIKPLNFINFEQA
IINIG----------T----NA--DDEFAYDNECPKHQVLIHPFSFANRLVTNGEYLDFINAGGYSNPQYWL
SDGWAHIQNTRLTHPLYWH---CIN----------NEWF-EFTHYGLQPLNLSAPISHVSYFEASAYANFV-
----KA--RLPTEFEWEYAAKNTP------------------LTDTNNNYLTPQQAKDDT--------EINQ
LTDSC-WQWTNSAYLPYPGFKPIEGVA-----GEYNGKFM----NN-----QM-VLRGGCVFTPQN----HL
RQTYRNFYYPHQAWMC--------------------------------------------------------
-------------------SGIRLAKDI
>A0A2S7USJ8_9GAMM/1-384 
------------ML-LNQYNKTRKYTESLCSPLNIED-YIPQAV-DFTSPPKWHLAHTTWFF-EEMILTKFV
ADYA-VFDRHFG-FLFNSYYQTVGEKALRAQRGIMTRPTVEQVYQYRHYVDGHIQRLLS------DDI----
SEEIQALIILGINHEQQHQELLLTDLKYTLSLNPTHP-VYHPDF-D---LVSQPLV---RTEEKQWLSFSEG
VYEIG----------Y----KD--SG-FCFDNELGRHKVYLQNFQIATSLVTNAEYIEFIESGGYSTFQYWL
DDGWAWLCNNQINSPLYWQ---YLD----------GQWY-YYTLAGLKLVEPDAIISHVSYYEANAFATWK-
----KM--RLATEFEWEIAATQFN------------------------------------------------
-WGQR-WEWTSSAYLPYPGFAISEGAV-----GEYNGKFM----VN-----QM-VLRGASVATSEN----HS
RASYRNFFQPQCQWQF--------------------------------------------------------
-------------------SGIRLVK--
>A0A2A9CFP9_9BACI/2-427 
VHQSIQLSELREQL-LHSFEAIRAMTNTLVETLETED-FTIQSI-PDVSPPKWHMAHTTWFF-ETFILKQYK
ENYE-SFHKEFD-YLFNSYYESVGSYFPRHSRGLLSRPSIDKVRSYRSDINEEIVNLIQ--QLDEGHL----
-HQVADLVEIGLNHEQQHQELLMTDIKYNFSINPLYP-VYRPLDGE---PTA-------KATPLEWVSFEGG
LIETG---------MD----ED--DG-FSFDNERPVHKVWLEPFKLATRTVTNGEYMEFINAGGYEQAAYWL
SDGWATVKKENWKAPLHWI---EKD----------GEWY-AFTLHGLVPINKEEPVTHVSYYEAEAYASFV-
----GK--RLPSESEWEVAVRDQPIA----------------GNFVEDGHYHPVASVKEE--EG----NIKK
AYGDV-WEWTKSPYMPYPGNKPLEGAL-----GEYNAKFM----SS-----QM-ILRGGSCVTSQT----HI
RPTYRNFFGPEKRWQF--------------------------------------------------------
-------------------TGIRLAEDA
>A0A1G9VCK2_9BACI/1-424 
----MSIQMIDQEKLANEYMGVRSFTERLVQPLNMED-FIIQSM-EDASPPKWHLAHTTWFF-ERFLLKEFL
TDYN-GFDDHFD-YLFNSYYETAGPFHPRIERGLITRPSVEEVFAYRKHVDKYIKELIM--SDSMGEM----
GDEIGSLLEIGLNHEQQHQELLLTDIKYNLSRNPFLP-AYQRNE-C---NASEP-----STGPVSFIEMEGG
LVEIG----------N----NG--KS-FCFDNEKPVHKVWLDSYRLAKRPVTNDEFCAFIEDGGYKKPQYWL
SDGWSTVQKNQWEAPLYWF---KRE----------EEWY-TYTLAGEQQLNPNDPVCHVSFYEADAFARWS-
----GK--RLPTEEEWENACTLQT-------IE---------GNLADSGKFHPQAAQHTN--EK----LFLQ
AFGDV-WEWTKSPYVSYPGNKPYEGTL-----GEYNAKFM----CN-----QM-VLRGGSCATPAS----HI
RATYRNFFQPEKRWQF--------------------------------------------------------
-------------------SGFRLAEDI
>A0A2W2EGZ7_9ACTN/1-428 Hercynine oxygenase
------MNDFKERI-AAELIAVRERSLAYTEA-DDEL-LVRQHS-PLMSPLVWDLAHVGNYE-ELWVLRE-A
AGID-PVRPEID-DIYDAF------KTPRKDRPSLPFLGPAEARRYIEGVRGRVLDVLDRIDLENASP----
LHRDGFVFGLVIQHEHQHDETMLATLQLSGQPGLVRD-AALPPG---------------RDAGPEEVYVPAG
GFLMG----------T----DT--LP-WAYDNERPAHWVDLPGYWIDRLPVGNRAYAAFIEDGGYDDPRWWT
PEGWRWRQNTGAKGPLFWE---NDG----------RSWW-RTRFGRTEPVPMDEPVQHVCWYEADAYARWA-
----GK--RLPTEAEWEKACGWDPSERRARRYPWGEADPG--PSLANLGHRAARPAPLGAYPDGASAYGAEQ
MVGDV-WEWTGSWFQPYPGFRSFPY-------KEYSEVFF----GQ-----EYRVLRGGSWAADPA----AV
RTTFRNWDYPIRRQIF--------------------------------------------------------
-------------------TGFRCARSE
>A0A1V4EEU5_9ACTN/1-428 Hercynine oxygenase
-MGNAGPTGLKERI-AAELAAVRERSLTYTDA-DDDM-LVRQHS-PLMSPLVWDLAHVGNYE-ELWVLRE-V
GGIE-PLRPEID-HLYDAF------KYPRKDRPSLPLLGPAEARKYISGVRGRVLDVLDRVDLTDPDP----
LRAGGYVFGLVLQHEHQHDETMLATLQLSRRPGLVRD-GELPPG---------------RPAAEPEVHIPAG
VFTMG----------T----DT--VA-WAYDNERPAHRMYLPGYWIDRHPVTNGAYLEFVEDGGYRDPRWWL
PQGWEWVERNGVEAPLFWT---RDG----------DTWW-RVRFGREEPVPPDEPVQHVSWYEADAYARWA-
----GK--RLPTEAEWEKACGGRT-------YPWGEADPGHLARWANLGHRAARPAPAGAYPDGASPYGVEQ
LIGDV-WEWTDSWFQPYPGYRCFPY-------EEYSKVFF----GE-----TYRVLRGGSWATHPC----AV
RTTFRNWDYPIRRQIF--------------------------------------------------------
-------------------AGFRCARSE
