ID SYH_ECOLI Reviewed; 424 AA. AC P60906; P04804; DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 23-JAN-2007, entry version 38. DE Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) DE (HisRS). GN Name=hisS; OrderedLocusNames=b2514, JW2498; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE. RX MEDLINE=85261421; PubMed=2991272; RA Freedman R., Gibson B., Donovan D., Biemann K., Eisenbeis S.J., RA Parker J., Schimmel P.; RT "Primary structure of histidine-tRNA synthetase and characterization RT of hisS transcripts."; RL J. Biol. Chem. 260:10063-10068(1985). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX MEDLINE=97349980; PubMed=9205837; DOI=10.1093/dnares/4.2.91; RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., RA Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., RA Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., RA Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., RA Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., RA Yamagata S., Horiuchi T.; RT "Construction of a contiguous 874-kb sequence of the Escherichia coli- RT K12 genome corresponding to 50.0-68.8 min on the linkage map and RT analysis of its sequence features."; RL DNA Res. 4:91-113(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains RT MG1655 and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16. RX MEDLINE=83028525; PubMed=6290315; DOI=10.1016/0378-1119(82)90108-1; RA Eisenbeis S.J., Parker J.; RT "The nucleotide sequence of the promoter region of hisS, the RT structural gene for histidyl-tRNA synthetase."; RL Gene 18:107-114(1982). RN [6] RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS). RX MEDLINE=96016186; PubMed=7556055; RA Arnez J.G., Harris D.C., Mitschler A., Rees B., Francklyn C.S., RA Moras D.; RT "Crystal structure of histidyl-tRNA synthetase from Escherichia coli RT complexed with histidyl-adenylate."; RL EMBO J. 14:4143-4155(1995). RN [7] RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS). RX MEDLINE=97352765; PubMed=9207058; DOI=10.1073/pnas.94.14.7144; RA Arnez J.G., Augustine J.G., Moras D., Francklyn C.S.; RT "The first step of aminoacylation at the atomic level in histidyl-tRNA RT synthetase."; RL Proc. Natl. Acad. Sci. U.S.A. 94:7144-7149(1997). CC -!- CATALYTIC ACTIVITY: ATP + L-histidine + tRNA(His) = AMP + CC diphosphate + L-histidyl-tRNA(His). CC -!- SUBUNIT: Homodimer. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase CC family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M11843; AAA03226.1; -; Genomic_DNA. DR EMBL; U00096; AAC75567.1; -; Genomic_DNA. DR EMBL; AP009048; BAA16401.1; -; Genomic_DNA. DR PIR; A23890; SYECH. DR PDB; 1HTT; X-ray; A/B/C/D=1-424. DR PDB; 1KMM; X-ray; A/B/C/D=1-424. DR PDB; 1KMN; X-ray; A/B/C/D=1-424. DR IntAct; P60906; -. DR SWISS-2DPAGE; P60906; COLI. DR ECO2DBASE; F048.1; 6TH EDITION. DR GenomeReviews; U00096_GR; b2514. DR GenomeReviews; AP009048_GR; JW2498. DR KEGG; ecj:JW2498; -. DR KEGG; eco:b2514; -. DR EchoBASE; EB0448; -. DR EcoGene; EG10453; hisS. DR LinkHub; P60906; -. DR HAMAP; MF_00127; -; 1. DR InterPro; IPR004154; Anticodon_bd. DR InterPro; IPR004516; HisS. DR InterPro; IPR002314; tRNA-synt_2b. DR InterPro; IPR006195; tRNA_ligase_II. DR Gene3D; G3DSA:3.40.50.800; Anticodon_bd; 1. DR Pfam; PF03129; HGTP_anticodon; 1. DR Pfam; PF00587; tRNA-synt_2b; 1. DR PIRSF; PIRSF001549; His-tRNA_synth; 1. DR TIGRFAMs; TIGR00442; hisS; 1. DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1. KW 3D-structure; Aminoacyl-tRNA synthetase; ATP-binding; KW Complete proteome; Direct protein sequencing; Ligase; KW Nucleotide-binding; Protein biosynthesis. FT INIT_MET 1 1 Removed. FT CHAIN 2 424 Histidyl-tRNA synthetase. FT /FTId=PRO_0000136161. FT TURN 9 10 FT HELIX 16 34 FT TURN 35 37 FT STRAND 45 48 FT HELIX 49 56 FT STRAND 58 60 FT HELIX 61 65 FT TURN 66 66 FT STRAND 68 71 FT TURN 73 74 FT STRAND 77 80 FT HELIX 85 95 FT TURN 96 96 FT TURN 99 100 FT STRAND 103 112 FT STRAND 123 134 FT HELIX 138 154 FT TURN 155 156 FT HELIX 158 160 FT STRAND 162 167 FT HELIX 171 176 FT HELIX 231 245 FT TURN 246 248 FT TURN 255 256 FT TURN 262 263 FT STRAND 266 272 FT STRAND 281 287 FT TURN 289 290 FT HELIX 291 294 FT TURN 295 296 FT STRAND 302 308 FT HELIX 309 319 FT TURN 321 322 FT STRAND 330 335 FT TURN 338 339 FT HELIX 340 354 FT TURN 356 357 FT STRAND 360 362 FT HELIX 369 379 FT TURN 380 380 FT STRAND 382 387 FT HELIX 389 394 FT TURN 395 395 FT STRAND 396 401 FT TURN 402 404 FT STRAND 407 411 FT HELIX 412 423 SQ SEQUENCE 424 AA; 47029 MW; EBBA69DE488CB00D CRC64; MAKNIQAIRG MNDYLPGETA IWQRIEGTLK NVLGSYGYSE IRLPIVEQTP LFKRAIGEVT DVVEKEMYTF EDRNGDSLTL RPEGTAGCVR AGIEHGLLYN QEQRLWYIGP MFRHERPQKG RYRQFHQLGC EVFGLQGPDI DAELIMLTAR WWRALGISEH VTLELNSIGS LEARANYRDA LVAFLEQHKE KLDEDCKRRM YTNPLRVLDS KNPEVQALLN DAPALGDYLD EESREHFAGL CKLLESAGIA YTVNQRLVRG LDYYNRTVFE WVTNSLGSQG TVCAGGRYDG LVEQLGGRAT PAVGFAMGLE RLVLLVQAVN PEFKADPVVD IYLVASGADT QSAAMALAER LRDELPGVKL MTNHGGGNFK KQFARADKWG ARVAVVLGES EVANGTAVVK DLRSGEQTAV AQDSVAAHLR TLLG //