Analysis Type: PANTHER Overrepresentation Test (Released 20221013) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.6799722 Released 2022-07-01 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20589) upload_1 (38) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) neutral lipid metabolic process (GO:0006638) 98 28 .18 + > 100 1.82E-55 1.42E-51 acylglycerol metabolic process (GO:0006639) 97 28 .18 + > 100 1.41E-55 2.22E-51 glycerolipid metabolic process (GO:0046486) 362 29 .67 + 43.41 5.57E-43 2.91E-39 lipid metabolic process (GO:0006629) 1234 36 2.28 + 15.81 1.02E-41 3.99E-38 diacylglycerol metabolic process (GO:0046339) 25 17 .05 + > 100 1.16E-37 3.63E-34 cellular lipid metabolic process (GO:0044255) 928 32 1.71 + 18.68 3.01E-37 7.87E-34 triglyceride metabolic process (GO:0006641) 70 15 .13 + > 100 6.53E-27 1.46E-23 neutral lipid catabolic process (GO:0046461) 30 12 .06 + > 100 2.34E-24 4.08E-21 acylglycerol catabolic process (GO:0046464) 30 12 .06 + > 100 2.34E-24 4.59E-21 glycerolipid biosynthetic process (GO:0045017) 225 17 .42 + 40.94 1.98E-23 3.11E-20 lipid catabolic process (GO:0016042) 297 18 .55 + 32.84 3.20E-23 4.56E-20 lipid biosynthetic process (GO:0008610) 604 21 1.11 + 18.84 1.65E-22 2.15E-19 lipid phosphorylation (GO:0046834) 16 10 .03 + > 100 6.42E-22 7.75E-19 glycerolipid catabolic process (GO:0046503) 54 12 .10 + > 100 1.01E-21 1.14E-18 protein kinase C-activating G protein-coupled receptor signaling pathway (GO:0007205) 27 10 .05 + > 100 4.15E-20 4.34E-17 phosphatidic acid biosynthetic process (GO:0006654) 32 10 .06 + > 100 1.74E-19 1.71E-16 phosphatidic acid metabolic process (GO:0046473) 36 10 .07 + > 100 4.81E-19 4.43E-16 triglyceride catabolic process (GO:0019433) 20 9 .04 + > 100 8.56E-19 7.46E-16 cellular lipid catabolic process (GO:0044242) 191 13 .35 + 36.88 2.57E-17 2.12E-14 olefinic compound metabolic process (GO:0120254) 148 12 .27 + 43.93 7.10E-17 5.57E-14 phospholipid metabolic process (GO:0006644) 367 15 .68 + 22.15 8.26E-17 6.17E-14 primary metabolic process (GO:0044238) 7228 37 13.34 + 2.77 4.02E-16 2.86E-13 neutral lipid biosynthetic process (GO:0046460) 27 8 .05 + > 100 1.37E-15 8.95E-13 acylglycerol biosynthetic process (GO:0046463) 27 8 .05 + > 100 1.37E-15 9.34E-13 organic substance metabolic process (GO:0071704) 7697 37 14.21 + 2.60 3.95E-15 2.38E-12 platelet activation (GO:0030168) 97 10 .18 + 55.86 3.84E-15 2.41E-12 monoacylglycerol metabolic process (GO:0046462) 14 7 .03 + > 100 4.57E-15 2.66E-12 small molecule metabolic process (GO:0044281) 1654 22 3.05 + 7.21 5.67E-15 3.07E-12 glycerophospholipid metabolic process (GO:0006650) 295 13 .54 + 23.88 5.52E-15 3.09E-12 organophosphate metabolic process (GO:0019637) 931 18 1.72 + 10.48 1.02E-14 5.35E-12 alcohol metabolic process (GO:0006066) 326 13 .60 + 21.61 1.90E-14 9.60E-12 metabolic process (GO:0008152) 8131 37 15.01 + 2.47 2.90E-14 1.42E-11 triglyceride biosynthetic process (GO:0019432) 20 7 .04 + > 100 3.47E-14 1.65E-11 cellular metabolic process (GO:0044237) 6606 34 12.19 + 2.79 2.87E-13 1.32E-10 phosphate-containing compound metabolic process (GO:0006796) 1855 21 3.42 + 6.13 7.71E-13 3.45E-10 blood coagulation (GO:0007596) 173 10 .32 + 31.32 8.99E-13 3.92E-10 phosphorus metabolic process (GO:0006793) 1881 21 3.47 + 6.05 1.01E-12 4.16E-10 coagulation (GO:0050817) 175 10 .32 + 30.96 1.00E-12 4.25E-10 hemostasis (GO:0007599) 178 10 .33 + 30.44 1.18E-12 4.74E-10 lipid modification (GO:0030258) 180 10 .33 + 30.10 1.31E-12 5.14E-10 organic hydroxy compound metabolic process (GO:1901615) 485 13 .90 + 14.52 2.53E-12 9.68E-10 glycerophospholipid biosynthetic process (GO:0046474) 205 10 .38 + 26.43 4.50E-12 1.68E-09 primary alcohol metabolic process (GO:0034308) 98 8 .18 + 44.23 1.60E-11 5.84E-09 organic substance catabolic process (GO:1901575) 1679 19 3.10 + 6.13 1.73E-11 6.18E-09 cellular biosynthetic process (GO:0044249) 2464 22 4.55 + 4.84 1.79E-11 6.23E-09 retinol metabolic process (GO:0042572) 55 7 .10 + 68.96 1.83E-11 6.25E-09 lipid homeostasis (GO:0055088) 162 9 .30 + 30.10 1.98E-11 6.62E-09 wound healing (GO:0042060) 338 11 .62 + 17.63 2.22E-11 7.27E-09 phospholipid biosynthetic process (GO:0008654) 246 10 .45 + 22.03 2.53E-11 8.11E-09 biosynthetic process (GO:0009058) 2603 22 4.80 + 4.58 5.29E-11 1.66E-08 regulation of body fluid levels (GO:0050878) 375 11 .69 + 15.89 6.54E-11 2.01E-08 regulation of biological quality (GO:0065008) 3677 25 6.79 + 3.68 9.85E-11 2.97E-08 catabolic process (GO:0009056) 1974 19 3.64 + 5.22 2.79E-10 8.25E-08 organic substance biosynthetic process (GO:1901576) 2534 21 4.68 + 4.49 2.88E-10 8.37E-08 retinoid metabolic process (GO:0001523) 87 7 .16 + 43.59 3.66E-10 1.04E-07 fatty acid metabolic process (GO:0006631) 328 10 .61 + 16.52 3.85E-10 1.08E-07 response to wounding (GO:0009611) 447 11 .83 + 13.33 4.02E-10 1.11E-07 diterpenoid metabolic process (GO:0016101) 90 7 .17 + 42.14 4.57E-10 1.24E-07 terpenoid metabolic process (GO:0006721) 101 7 .19 + 37.55 9.78E-10 2.60E-07 glycerol metabolic process (GO:0006071) 21 5 .04 + > 100 1.03E-09 2.70E-07 alditol metabolic process (GO:0019400) 23 5 .04 + > 100 1.54E-09 3.95E-07 isoprenoid metabolic process (GO:0006720) 121 7 .22 + 31.34 3.23E-09 8.04E-07 monoacylglycerol biosynthetic process (GO:0006640) 7 4 .01 + > 100 3.20E-09 8.10E-07 diacylglycerol biosynthetic process (GO:0006651) 8 4 .01 + > 100 4.79E-09 1.17E-06 cellular hormone metabolic process (GO:0034754) 132 7 .24 + 28.73 5.75E-09 1.39E-06 monocarboxylic acid metabolic process (GO:0032787) 508 10 .94 + 10.67 2.30E-08 5.46E-06 organophosphate biosynthetic process (GO:0090407) 549 10 1.01 + 9.87 4.71E-08 1.10E-05 long-chain fatty acid metabolic process (GO:0001676) 111 6 .20 + 29.29 6.97E-08 1.61E-05 regulation of plasma lipoprotein particle levels (GO:0097006) 54 5 .10 + 50.17 7.52E-08 1.71E-05 arachidonic acid metabolic process (GO:0019369) 58 5 .11 + 46.71 1.05E-07 2.35E-05 hormone metabolic process (GO:0042445) 209 7 .39 + 18.15 1.20E-07 2.65E-05 positive regulation of triglyceride metabolic process (GO:0090208) 23 4 .04 + 94.23 1.67E-07 3.63E-05 carboxylic acid metabolic process (GO:0019752) 822 11 1.52 + 7.25 1.93E-07 4.15E-05 oxoacid metabolic process (GO:0043436) 848 11 1.57 + 7.03 2.63E-07 5.57E-05 organic acid metabolic process (GO:0006082) 857 11 1.58 + 6.95 2.92E-07 6.10E-05 cell activation (GO:0001775) 700 10 1.29 + 7.74 4.33E-07 8.93E-05 positive regulation of lipid metabolic process (GO:0045834) 154 6 .28 + 21.11 4.46E-07 9.08E-05 phosphorylation (GO:0016310) 918 11 1.69 + 6.49 5.73E-07 1.15E-04 cellular catabolic process (GO:0044248) 1625 14 3.00 + 4.67 5.91E-07 1.17E-04 monoacylglycerol catabolic process (GO:0052651) 7 3 .01 + > 100 6.86E-07 1.34E-04 cholesterol homeostasis (GO:0042632) 89 5 .16 + 30.44 7.87E-07 1.52E-04 sterol homeostasis (GO:0055092) 90 5 .17 + 30.10 8.29E-07 1.59E-04 acylglycerol homeostasis (GO:0055090) 38 4 .07 + 57.03 1.04E-06 1.95E-04 triglyceride homeostasis (GO:0070328) 38 4 .07 + 57.03 1.04E-06 1.97E-04 G protein-coupled receptor signaling pathway (GO:0007186) 1223 12 2.26 + 5.32 1.27E-06 2.29E-04 regulation of triglyceride metabolic process (GO:0090207) 40 4 .07 + 54.18 1.26E-06 2.30E-04 positive regulation of triglyceride catabolic process (GO:0010898) 9 3 .02 + > 100 1.25E-06 2.31E-04 plasma lipoprotein particle organization (GO:0071827) 42 4 .08 + 51.60 1.51E-06 2.69E-04 unsaturated fatty acid metabolic process (GO:0033559) 103 5 .19 + 26.30 1.57E-06 2.76E-04 polyol metabolic process (GO:0019751) 105 5 .19 + 25.80 1.72E-06 2.99E-04 protein-lipid complex subunit organization (GO:0071825) 45 4 .08 + 48.16 1.95E-06 3.37E-04 phospholipid catabolic process (GO:0009395) 48 4 .09 + 45.15 2.49E-06 4.24E-04 icosanoid metabolic process (GO:0006690) 116 5 .21 + 23.35 2.75E-06 4.63E-04 regulation of lipid metabolic process (GO:0019216) 346 7 .64 + 10.96 3.24E-06 5.40E-04 fatty acid biosynthetic process (GO:0006633) 121 5 .22 + 22.39 3.35E-06 5.54E-04 regulation of triglyceride catabolic process (GO:0010896) 14 3 .03 + > 100 3.85E-06 6.29E-04 regulation of hormone levels (GO:0010817) 528 8 .97 + 8.21 4.85E-06 7.85E-04 lipid localization (GO:0010876) 370 7 .68 + 10.25 4.99E-06 7.99E-04 cholesterol transport (GO:0030301) 65 4 .12 + 33.34 7.77E-06 1.23E-03 monocarboxylic acid biosynthetic process (GO:0072330) 166 5 .31 + 16.32 1.49E-05 2.33E-03 cellular carbohydrate metabolic process (GO:0044262) 172 5 .32 + 15.75 1.75E-05 2.72E-03 sterol transport (GO:0015918) 83 4 .15 + 26.11 1.95E-05 3.00E-03 positive regulation of lipid catabolic process (GO:0050996) 28 3 .05 + 58.05 2.50E-05 3.81E-03 multicellular organismal process (GO:0032501) 6581 25 12.15 + 2.06 2.77E-05 4.10E-03 protein-lipid complex remodeling (GO:0034368) 29 3 .05 + 56.05 2.76E-05 4.12E-03 plasma lipoprotein particle remodeling (GO:0034369) 29 3 .05 + 56.05 2.76E-05 4.16E-03 protein-containing complex remodeling (GO:0034367) 31 3 .06 + 52.43 3.32E-05 4.77E-03 regulation of endocannabinoid signaling pathway (GO:2000124) 3 2 .01 + > 100 3.29E-05 4.78E-03 endocannabinoid signaling pathway (GO:0071926) 3 2 .01 + > 100 3.29E-05 4.83E-03 chemical homeostasis (GO:0048878) 916 9 1.69 + 5.32 3.55E-05 5.06E-03 intestinal absorption (GO:0050892) 32 3 .06 + 50.80 3.62E-05 5.12E-03 diacylglycerol catabolic process (GO:0046340) 4 2 .01 + > 100 4.93E-05 6.79E-03 acylglycerol acyl-chain remodeling (GO:0036155) 4 2 .01 + > 100 4.93E-05 6.85E-03 negative regulation of protein kinase C signaling (GO:0090038) 4 2 .01 + > 100 4.93E-05 6.91E-03 lipid storage (GO:0019915) 42 3 .08 + 38.70 7.76E-05 1.06E-02 positive regulation of lipoprotein particle clearance (GO:0010986) 6 2 .01 + > 100 9.19E-05 1.24E-02 cannabinoid signaling pathway (GO:0038171) 7 2 .01 + > 100 1.18E-04 1.58E-02 carboxylic acid biosynthetic process (GO:0046394) 272 5 .50 + 9.96 1.47E-04 1.95E-02 organic acid biosynthetic process (GO:0016053) 274 5 .51 + 9.89 1.52E-04 2.00E-02 very-low-density lipoprotein particle remodeling (GO:0034372) 9 2 .02 + > 100 1.80E-04 2.35E-02 organophosphate catabolic process (GO:0046434) 156 4 .29 + 13.89 2.10E-04 2.72E-02 triglyceride-rich lipoprotein particle remodeling (GO:0034370) 10 2 .02 + > 100 2.16E-04 2.75E-02 positive regulation of triglyceride lipase activity (GO:0061365) 10 2 .02 + > 100 2.16E-04 2.77E-02 response to fatty acid (GO:0070542) 63 3 .12 + 25.80 2.44E-04 3.06E-02 regulation of lipid catabolic process (GO:0050994) 63 3 .12 + 25.80 2.44E-04 3.08E-02 intestinal cholesterol absorption (GO:0030299) 11 2 .02 + 98.51 2.54E-04 3.14E-02 organic hydroxy compound transport (GO:0015850) 164 4 .30 + 13.22 2.53E-04 3.14E-02 alditol phosphate metabolic process (GO:0052646) 12 2 .02 + 90.30 2.97E-04 3.63E-02 intracellular signal transduction (GO:0035556) 1511 10 2.79 + 3.59 3.22E-04 3.92E-02 digestive system process (GO:0022600) 74 3 .14 + 21.97 3.84E-04 4.63E-02 neurotransmitter biosynthetic process (GO:0042136) 14 2 .03 + 77.40 3.90E-04 4.63E-02 intestinal lipid absorption (GO:0098856) 14 2 .03 + 77.40 3.90E-04 4.67E-02