RID: 2AJ8Y8S2013 Job Title:sp|Q9ZH99|IDH_COXBU Isocitrate dehydrogenase Program: BLASTP Query: sp|Q9ZH99|IDH_COXBU Isocitrate dehydrogenase [NADP] OS=Coxiella burnetii (strain RSA 493 / Nine Mile phase I) OX=227377 GN=icd PE=1 SV=1 ID: lcl|Query_4789313(amino acid) Length: 427 Database: swissprot Non-redundant UniProtKB/SwissProt sequences Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Coxiella bur... NA 227377 867 867 100% 0.0 100.00 427 Q9ZH99.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Pseudomonas ... NA 208963 670 670 97% 0.0 77.16 418 Q02NB5.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Escherichia ... NA 83333 648 648 96% 0.0 75.12 416 P08200.1 RecName: Full=Isocitrate dehydrogenase [NADP] 1; AltName:... Colwellia maris NA 77524 613 613 96% 0.0 71.12 415 P41560.2 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Helicobacter... NA 85962 600 600 96% 0.0 68.74 425 P56063.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Helicobacter... NA 85963 600 600 96% 0.0 68.74 425 Q9ZN36.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Bacillus sub... NA 224308 554 554 95% 0.0 66.20 423 P39126.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Staphylococc... NA 176279 542 542 95% 0.0 65.57 422 Q5HNL1.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Staphylococc... NA 282459 539 539 95% 0.0 64.39 422 Q6G8N2.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Staphylococc... NA 282458 539 539 95% 0.0 64.39 422 Q6GG12.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Staphylococc... NA 158878 538 538 95% 0.0 64.15 422 P65099.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Archaeoglobu... NA 224325 474 474 97% 2e-165 57.42 412 O29610.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Nostoc sp. P... NA 103690 471 471 97% 2e-163 51.80 473 P50214.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Streptococcu... NA 210007 462 462 94% 5e-161 55.04 393 Q59940.2 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Streptococcu... NA 1304 461 461 94% 7e-161 57.78 391 Q59985.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Haloferax vo... NA 309800 457 457 97% 5e-159 52.86 419 D4GU92.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Synechocysti... NA 1111708 453 453 97% 2e-156 49.37 475 P80046.2 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Caldococcus ... NA 57174 372 372 97% 4e-125 48.69 429 P96318.2 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Aquifex aeol... NA 224324 351 351 96% 4e-117 46.52 426 O67480.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Thermus ther... NA 300852 199 199 91% 2e-57 34.18 496 P33197.2 RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subuni... Dictyosteliu... NA 44689 178 178 90% 4e-51 31.79 354 Q55BI2.1 RecName: Full=Isocitrate dehydrogenase [NAD] catalytic subunit... Arabidopsis ... thale cress 3702 177 177 89% 2e-50 32.56 374 Q945K7.1 RecName: Full=Homoisocitrate dehydrogenase; Short=HICDH;... Methanocaldo... NA 243232 175 175 90% 6e-50 28.82 347 Q58991.3 RecName: Full=Probable isocitrate dehydrogenase [NAD] subunit... Drosophila m... fruit fly 7227 175 175 85% 2e-49 33.33 377 Q9VWH4.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Rickettsia f... NA 315456 177 177 89% 4e-49 31.59 483 Q4UKR1.2 RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha,... Macaca fasci... crab-eating ... 9541 172 172 85% 6e-49 32.25 347 Q28480.2 RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha,... Mus musculus house mouse 10090 172 172 85% 2e-48 32.25 366 Q9D6R2.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Rickettsia b... NA 336407 174 174 89% 3e-48 32.21 483 Q1RJU4.1 RecName: Full=Isocitrate dehydrogenase [NAD] subunit 2,... Kluyveromyce... NA 284590 171 171 90% 4e-48 32.06 368 O94230.1 RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha,... Pongo abelii Sumatran ora... 9601 170 170 85% 1e-47 31.98 366 Q5R678.1 RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha,... Homo sapiens human 9606 170 170 85% 1e-47 31.17 366 P50213.1 RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha,... Sus scrofa pig 9823 169 169 85% 1e-47 31.98 366 P56471.2 RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha,... Bos taurus cattle 9913 169 169 85% 2e-47 31.88 366 P41563.1 RecName: Full=Isocitrate/homoisocitrate dehydrogenase; AltName... Thermus ther... NA 300852 168 168 90% 3e-47 32.23 334 Q5SIJ1.1 RecName: Full=Isocitrate dehydrogenase [NAD] subunit 2,... Schizosaccha... NA 284812 169 169 90% 3e-47 30.56 379 Q9USP8.2 RecName: Full=Isocitrate dehydrogenase [NAD] subunit 2,... Saccharomyce... NA 559292 168 168 90% 6e-47 30.79 369 P28241.1 RecName: Full=Probable isocitrate dehydrogenase [NAD] subunit... Caenorhabdit... NA 6239 167 167 83% 8e-47 32.50 358 Q93714.3 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Rickettsia p... NA 272947 169 169 89% 2e-46 30.55 483 Q9ZDR0.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Rickettsia c... NA 272944 169 169 89% 3e-46 30.83 483 Q92IR7.1 RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subuni... Arabidopsis ... thale cress 3702 166 166 85% 3e-46 31.82 367 Q8LFC0.2 RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha,... Rattus norve... Norway rat 10116 166 166 85% 4e-46 32.26 366 Q99NA5.1 RecName: Full=3-isopropylmalate dehydrogenase, chloroplastic;... Solanum tube... potato 4113 165 165 81% 5e-46 31.91 357 P29696.1 RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH;... Rickettsia t... NA 257363 168 168 89% 5e-46 30.55 483 Q68XA5.1 RecName: Full=Isocitrate dehydrogenase [NAD] catalytic subunit... Arabidopsis ... thale cress 3702 164 164 95% 2e-45 30.90 374 Q8LG77.2 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Methanotherm... NA 187420 160 160 90% 1e-44 30.41 329 O27441.1 RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subuni... Arabidopsis ... thale cress 3702 159 159 86% 2e-43 31.83 367 P93032.2 RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subuni... Arabidopsis ... thale cress 3702 159 159 85% 2e-43 31.99 368 O81796.1 RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subuni... Dictyosteliu... NA 44689 158 158 91% 2e-43 32.49 360 Q54B68.1 RecName: Full=3-isopropylmalate/3-methylmalate dehydrogenase;... Methanocaldo... NA 243232 157 157 82% 3e-43 34.46 333 Q58130.2 RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1,... Histoplasma ... NA 5037 153 153 90% 4e-41 29.92 388 O13302.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Archaeoglobu... NA 224325 149 149 88% 2e-40 30.97 326 O29627.1 RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1,... Schizosaccha... NA 284812 145 145 90% 9e-39 30.89 356 O13696.1 RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1,... Kluyveromyce... NA 284590 142 142 91% 3e-37 28.64 361 O94229.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Saccharolobu... NA 273057 141 141 78% 4e-37 31.55 336 Q9UXB2.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Sulfurisphae... NA 273063 136 136 78% 2e-35 29.85 337 P50455.3 RecName: Full=Homoisocitrate dehydrogenase, mitochondrial;... Saccharomyce... NA 559292 133 133 84% 5e-34 28.53 371 P40495.1 RecName: Full=Homoisocitrate dehydrogenase; Short=HICDH... Schizosaccha... NA 284812 131 131 86% 3e-33 27.51 362 O14104.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bifidobacter... NA 205913 128 128 90% 3e-32 29.90 343 B3DTF8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Nocardia far... NA 247156 127 127 79% 4e-32 31.70 335 Q5YRX2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Corynebacter... NA 340322 127 127 90% 7e-32 29.77 340 A4QDP9.1 RecName: Full=3-isopropylmalate dehydrogenase [Haloferax... Haloferax vo... NA 309800 125 125 90% 2e-31 28.09 324 D4GYE8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Corynebacter... NA 196627 125 125 90% 2e-31 29.77 340 P94631.1 RecName: Full=Isocitrate/homoisocitrate dehydrogenase;... Pyrococcus h... NA 70601 125 125 82% 2e-31 28.97 345 O59394.2 RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1,... Saccharomyce... NA 559292 125 125 91% 3e-31 27.02 360 P28834.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Leifsonia xy... NA 281090 125 125 89% 4e-31 29.65 357 Q6AEP6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bifidobacter... NA 391904 124 124 90% 5e-31 29.65 343 B7GUI8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Clavibacter ... NA 443906 122 122 77% 6e-30 29.03 355 A5CPZ4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Corynebacter... NA 196164 120 120 79% 2e-29 30.55 340 Q8FPV5.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Clavibacter ... NA 31964 120 120 77% 2e-29 31.29 355 B0RIP4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Streptomyces... NA 455632 119 119 90% 5e-29 28.28 347 B1VZ57.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Streptomyces... NA 100226 117 117 80% 2e-28 29.31 347 O86504.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Beutenbergia... NA 471853 116 116 90% 4e-28 27.66 347 C5C2I9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Thermobifida... NA 269800 116 116 84% 6e-28 28.76 354 Q47SB4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Streptomyces... NA 227882 115 115 79% 1e-27 28.90 347 Q82JN6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Corynebacter... NA 504474 113 113 82% 5e-27 29.28 339 B1VG35.1 RecName: Full=D-malate dehydrogenase [decarboxylating]; AltNam... Escherichia ... NA 83333 114 114 90% 6e-27 27.25 361 P76251.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Zymomonas mo... NA 264203 113 113 90% 8e-27 27.86 349 Q5NPQ9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Corynebacter... NA 548476 113 113 84% 8e-27 28.07 339 C3PFX5.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Corynebacter... NA 306537 112 112 90% 2e-26 26.84 338 Q4JUQ0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bacillus lic... NA 279010 110 110 88% 8e-26 29.10 370 Q65GI9.2 RecName: Full=Protein DlpA [Legionella pneumophila subsp.... Legionella p... NA 272624 113 113 90% 8e-26 26.23 615 Q48806.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Mycobacteriu... NA 419947 110 110 89% 9e-26 27.30 336 A5U706.1 RecName: Full=Tartrate dehydrogenase/decarboxylase; Short=TDH;... Pseudomonas ... NA 303 109 109 89% 2e-25 28.18 365 Q51945.3 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Mycobacteriu... NA 410289 108 108 89% 5e-25 27.30 336 A1KMY9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Desulfitobac... NA 138119 107 107 90% 1e-24 27.52 352 Q24XT2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Symbiobacter... NA 292459 106 106 90% 4e-24 26.89 368 Q67JY2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Streptococcu... NA 171101 105 105 89% 4e-24 29.22 345 Q8DPJ4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Aquifex aeol... NA 224324 105 105 90% 7e-24 25.68 364 O66607.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Acidithiobac... NA 920 104 104 90% 1e-23 26.91 358 Q56268.1 RecName: Full=Probable isocitrate dehydrogenase [NAD] gamma 2,... Rattus norve... Norway rat 10116 105 105 84% 1e-23 25.47 395 Q4QQT5.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Priestia meg... NA 592022 104 104 85% 2e-23 26.70 369 P41019.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Chlorobaculu... NA 194439 103 103 90% 2e-23 27.54 352 P59028.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Geobacillus ... NA 235909 103 103 91% 3e-23 28.75 371 Q5KWJ4.1 RecName: Full=Probable isocitrate dehydrogenase [NAD] gamma 2,... Mus musculus house mouse 10090 103 103 85% 3e-23 25.00 396 Q8BPC6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bacillus sub... NA 224308 102 102 88% 5e-23 27.39 365 P05645.3 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Saccharopoly... NA 405948 102 102 79% 5e-23 27.17 347 A4FMQ2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Carboxydothe... NA 246194 102 102 91% 5e-23 27.63 374 Q3AEQ2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Mycolicibact... NA 350058 102 102 90% 7e-23 26.84 336 A1T6Z4.1 RecName: Full=3-isopropylmalate dehydrogenase, chloroplastic;... Brassica napus rape 3708 102 102 90% 1e-22 28.50 406 P29102.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Frankia sp. ... NA 298653 100 100 80% 2e-22 29.75 342 A8L554.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Synechococcu... NA 316279 100 100 90% 3e-22 26.32 357 Q3AYS1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Salinibacter... NA 309807 100 100 89% 3e-22 29.62 365 Q2S0M8.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Moorella the... NA 264732 100 100 79% 4e-22 28.37 357 Q2RGA0.1 RecName: Full=3-isopropylmalate dehydrogenase 2, chloroplastic... Arabidopsis ... thale cress 3702 100 100 91% 5e-22 27.98 405 P93832.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Rhodococcus ... NA 632772 99.0 99.0 89% 8e-22 27.88 336 C1B2M3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Oceanobacill... NA 221109 98.6 98.6 90% 1e-21 25.99 366 Q8EN68.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Halalkalibac... NA 272558 98.6 98.6 90% 2e-21 25.99 363 Q9K8E9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Heyndrickxia... NA 1398 98.2 98.2 90% 2e-21 25.43 366 P12010.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Rhodococcus ... NA 101510 97.8 97.8 89% 2e-21 27.62 336 Q0S2H1.1 RecName: Full=Probable tartrate dehydrogenase/decarboxylase;... Bacillus sub... NA 224308 97.4 97.4 80% 3e-21 25.14 354 P42958.4 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bordetella a... NA 360910 97.4 97.4 90% 3e-21 28.08 358 Q2KYL5.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Chromobacter... NA 243365 97.4 97.4 90% 4e-21 27.46 354 Q7NUC2.1 RecName: Full=3-isopropylmalate dehydrogenase 2; AltName:... Dechloromona... NA 159087 96.7 96.7 89% 7e-21 27.92 358 Q479H7.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Burkholderia... NA 482957 96.3 96.3 90% 7e-21 27.68 355 Q393X4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Desulfotalea... NA 177439 96.3 96.3 90% 1e-20 27.36 357 Q6ANR1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Haemophilus ... NA 281310 95.5 95.5 90% 1e-20 26.12 358 Q4QLS3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Lactococcus ... NA 272623 95.1 95.1 90% 2e-20 25.19 345 Q02143.3 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Clostridium ... NA 272562 95.1 95.1 90% 2e-20 27.93 357 Q97EE2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Shouchella c... NA 66692 95.1 95.1 90% 2e-20 26.00 364 Q5WEN4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Neisseria go... NA 242231 95.1 95.1 90% 2e-20 26.88 356 Q5F8T6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Neisseria me... NA 122586 94.7 94.7 90% 3e-20 27.57 356 Q9JZI9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Burkholderia... NA 395019 94.7 94.7 90% 3e-20 27.43 355 Q845W3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Methylococcu... NA 243233 94.7 94.7 90% 3e-20 27.79 360 Q606F4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Parasynechoc... NA 84588 94.7 94.7 90% 3e-20 26.18 357 Q7U840.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Caldanaeroba... NA 273068 94.7 94.7 90% 3e-20 26.85 355 Q8RDK0.1 RecName: Full=3-isopropylmalate dehydrogenase 3, chloroplastic... Arabidopsis ... thale cress 3702 95.1 95.1 92% 3e-20 27.12 404 Q9SA14.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Synechocysti... NA 1111708 94.7 94.7 90% 3e-20 26.82 362 P73960.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Psychrobacte... NA 259536 94.7 94.7 91% 4e-20 26.89 367 Q4FRV0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Haemophilus ... NA 71421 94.4 94.4 90% 4e-20 26.62 358 P43860.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Burkholderia... NA 320372 94.4 94.4 90% 4e-20 27.93 355 Q3JKG9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Acinetobacte... NA 62977 94.0 94.0 90% 5e-20 26.88 359 Q6FEV6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Burkholderia... NA 271848 93.6 93.6 90% 7e-20 27.18 355 Q2T7H6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Streptococcu... NA 210007 93.2 93.2 90% 9e-20 27.50 344 Q8DTG3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... [Bacillus] c... NA 1395 93.6 93.6 78% 9e-20 29.66 366 P05644.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Cupriavidus ... NA 266264 92.8 92.8 90% 1e-19 28.18 355 Q1LKH7.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Chlorobium c... NA 340177 92.8 92.8 90% 1e-19 25.88 352 Q3APC4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Leptospira i... NA 189518 92.8 92.8 89% 1e-19 25.63 358 P24015.1 RecName: Full=3-isopropylmalate dehydrogenase 1, chloroplastic... Arabidopsis ... thale cress 3702 93.2 93.2 90% 2e-19 27.41 409 Q9FMT1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bordetella p... NA 257311 92.8 92.8 90% 2e-19 26.80 358 Q7W929.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pelodictyon ... NA 319225 92.4 92.4 90% 2e-19 24.24 353 Q3B595.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bordetella p... NA 257313 92.4 92.4 90% 2e-19 27.30 358 Q7VY73.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Cupriavidus ... NA 264198 92.4 92.4 90% 2e-19 28.32 355 Q46YW0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Hydrogenovib... NA 317025 92.4 92.4 90% 2e-19 26.93 357 Q31HI0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Streptococcu... NA 299768 92.4 92.4 90% 2e-19 26.52 345 Q5LZF3.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Oleidesulfov... NA 207559 92.0 92.0 83% 2e-19 28.49 358 Q30WD0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Neisseria me... NA 122587 92.0 92.0 90% 2e-19 25.31 356 Q9JU79.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Sulfurimonas... NA 326298 91.7 91.7 90% 3e-19 26.11 355 Q30RK2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Saccharophag... NA 203122 91.7 91.7 90% 3e-19 27.50 357 Q21IY5.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Gluconobacte... NA 290633 91.7 91.7 90% 3e-19 25.62 369 Q5FUG5.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Prochlorococ... NA 74547 91.3 91.3 90% 5e-19 25.94 357 Q7V842.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Ralstonia ps... NA 267608 90.9 90.9 78% 6e-19 27.79 356 Q8XXX5.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Photobacteri... NA 298386 90.9 90.9 90% 7e-19 25.62 362 Q6LV25.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Synechococcu... NA 321327 90.9 90.9 90% 7e-19 27.93 381 Q2JTN8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Rhodospirill... NA 269796 90.9 90.9 90% 8e-19 26.76 370 Q2RV53.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Synechococcu... NA 110662 90.5 90.5 79% 9e-19 27.04 357 Q3AIH4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Deinococcus ... NA 243230 90.1 90.1 91% 1e-18 26.51 352 Q9RTH9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Colwellia ps... NA 167879 90.1 90.1 90% 1e-18 25.87 362 Q47WG3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Helicobacter... NA 235279 89.7 89.7 91% 2e-18 25.62 357 Q7VH33.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Aliivibrio f... NA 312309 89.7 89.7 91% 2e-18 25.25 363 Q5E857.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Neisseria la... NA 486 88.6 88.6 79% 2e-18 26.86 313 P50180.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Rhodococcus ... NA 234621 88.6 88.6 80% 3e-18 27.92 337 C0ZXM4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bacillus cer... NA 226900 89.0 89.0 90% 3e-18 24.37 354 Q81G11.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Syntrophotal... NA 338963 89.0 89.0 91% 3e-18 24.07 365 Q3A3B2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Vibrio vulni... NA 196600 89.0 89.0 91% 3e-18 26.04 363 Q7MP78.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Vibrio vulni... NA 216895 88.6 88.6 91% 4e-18 26.04 363 Q8DEE0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Vibrio chole... NA 243277 88.2 88.2 91% 5e-18 25.74 363 Q9KP82.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Nitrosomonas... NA 228410 88.2 88.2 70% 5e-18 26.06 356 Q82WI6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Frankia casu... NA 106370 87.8 87.8 78% 5e-18 28.12 342 Q2J6V8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Nitrosococcu... NA 323261 88.2 88.2 91% 6e-18 26.68 362 Q3JCC4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Synechococcu... NA 321332 87.8 87.8 85% 8e-18 27.89 371 Q2JL30.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bacillus ant... NA 1392 87.4 87.4 90% 9e-18 23.99 354 Q81T67.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Deinococcus ... NA 319795 87.4 87.4 79% 1e-17 28.73 351 Q1IZK2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Shewanella o... NA 211586 87.0 87.0 89% 1e-17 26.63 364 Q8E9N3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Hahella chej... NA 349521 86.7 86.7 89% 2e-17 27.27 360 Q2SJD6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... [Bacillus th... NA 281309 86.7 86.7 90% 2e-17 23.99 354 Q6HLF2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Gloeobacter ... NA 251221 86.3 86.3 90% 2e-17 29.10 362 Q7NFH4.1 RecName: Full=3-isopropylmalate dehydrogenase 1; AltName:... Dechloromona... NA 159087 86.3 86.3 90% 2e-17 25.69 350 Q47HR1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bacillus cer... NA 288681 86.3 86.3 90% 3e-17 23.99 354 Q63DX7.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Salmonella e... NA 99287 86.3 86.3 90% 3e-17 25.37 363 P37412.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Vibrio parah... NA 223926 85.9 85.9 91% 3e-17 25.31 363 Q87SS8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudomonas ... NA 208964 85.9 85.9 90% 3e-17 26.18 360 Q51375.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Nitrosospira... NA 323848 85.9 85.9 90% 3e-17 25.75 353 Q2Y7Q8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Staphylococc... NA 176280 85.9 85.9 84% 3e-17 26.61 347 Q8CNL2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Salmonella e... NA 295319 85.9 85.9 90% 3e-17 25.37 363 Q5PDG2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Escherichia ... NA 83334 85.9 85.9 90% 3e-17 25.62 363 Q8X9Z9.3 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Salmonella e... NA 90370 85.9 85.9 90% 4e-17 25.37 363 Q8Z9I1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Staphylococc... NA 176279 85.5 85.5 84% 4e-17 26.76 347 Q5HMF8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Shigella dys... NA 300267 85.5 85.5 90% 4e-17 25.37 363 Q32K21.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Chromohaloba... NA 290398 85.5 85.5 90% 5e-17 27.39 359 Q1QUR0.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Aromatoleum ... NA 76114 85.1 85.1 90% 5e-17 25.94 350 Q5P1J6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Escherichia ... NA 364106 85.1 85.1 90% 6e-17 26.12 364 Q1RGC4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Escherichia ... NA 199310 85.1 85.1 90% 6e-17 25.37 363 Q8FL76.3 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Nitratidesul... NA 882 85.1 85.1 78% 6e-17 26.93 357 Q726X1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Nostoc sp. P... NA 103690 85.1 85.1 33% 7e-17 36.81 362 Q8YXA2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Photorhabdus... NA 243265 84.7 84.7 90% 8e-17 25.62 363 Q7N128.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Escherichia ... NA 83333 84.3 84.3 90% 1e-16 25.37 363 P30125.3 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Psychrobacte... NA 335284 84.3 84.3 91% 1e-16 26.41 367 Q1QAF5.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudomonas ... NA 220664 84.0 84.0 90% 1e-16 26.20 360 Q4KF05.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Bacillus cer... NA 222523 84.0 84.0 90% 1e-16 23.74 354 Q73B99.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudomonas ... NA 205922 83.2 83.2 90% 3e-16 25.94 360 Q3KF21.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Trichormus v... NA 240292 83.2 83.2 33% 3e-16 36.11 362 Q3M8T9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Shigella boy... NA 300268 82.8 82.8 90% 4e-16 25.12 363 Q326G2.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Thermosynech... NA 197221 82.8 82.8 79% 4e-16 27.40 361 P59029.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Shigella son... NA 300269 82.4 82.4 90% 4e-16 25.87 363 Q3Z5T7.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Shigella fle... NA 623 82.4 82.4 90% 5e-16 25.12 363 Q83SP1.3 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Dehalococcoi... NA 255470 82.0 82.0 70% 6e-16 25.00 365 Q3ZXI7.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... [Mannheimia]... NA 221988 82.0 82.0 90% 6e-16 25.12 358 Q65V05.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pectobacteri... NA 218491 81.6 81.6 90% 9e-16 24.38 363 Q6D0G7.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudoaltero... NA 326442 81.3 81.3 80% 1e-15 26.94 358 Q3IJS3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Sodalis glos... NA 343509 79.7 79.7 89% 4e-15 25.70 364 Q2NVW4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudomonas ... NA 223283 79.3 79.3 90% 5e-15 26.13 360 Q884C0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Xylella fast... NA 183190 79.0 79.0 90% 7e-15 24.75 357 Q87BQ1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Xanthomonas ... NA 342109 79.0 79.0 90% 8e-15 24.38 357 Q2P762.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Xanthomonas ... NA 316273 79.0 79.0 90% 8e-15 25.00 357 Q3BPJ8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudomonas ... NA 205918 78.6 78.6 90% 8e-15 25.88 360 Q4ZUZ4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 224915 78.6 78.6 78% 1e-14 25.43 366 P59515.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudomonas ... NA 264730 78.2 78.2 90% 1e-14 25.88 360 Q48K97.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Pseudomonas ... NA 160488 78.2 78.2 90% 1e-14 25.19 360 Q88LE5.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Arthrospira ... NA 118562 78.2 78.2 31% 1e-14 36.96 355 Q00412.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Xylella fast... NA 160492 77.4 77.4 90% 2e-14 24.50 357 Q9PAX3.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 98799 77.0 77.0 91% 3e-14 25.93 363 P59027.1 RecName: Full=3-isopropylmalate dehydrogenase gloI; AltName:... Glarea lozoy... NA 1116229 77.0 77.0 32% 3e-14 34.67 373 S3DB74.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Xanthomonas ... NA 190486 76.6 76.6 90% 4e-14 25.00 357 Q8PH05.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Dehalococcoi... NA 243164 76.6 76.6 35% 5e-14 31.88 365 Q3Z896.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Xanthomonas ... NA 314565 75.1 75.1 79% 1e-13 25.36 357 Q4UYG2.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Synechococcu... NA 1140 75.1 75.1 27% 1e-13 38.02 365 Q31N34.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 98797 73.2 73.2 85% 6e-13 23.38 364 O31292.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Schizosaccha... NA 284812 71.6 71.6 90% 2e-12 26.33 371 P18869.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 372461 71.2 71.2 30% 3e-12 32.82 367 Q5WPZ9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 198804 69.3 69.3 32% 1e-11 30.00 363 O85064.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118119 68.9 68.9 32% 1e-11 30.71 364 Q9EVI1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118105 68.6 68.6 28% 2e-11 31.15 365 Q9EVG3.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Sordaria mac... NA 5147 68.2 68.2 33% 2e-11 33.13 368 Q6TWC4.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Neurospora c... NA 367110 68.2 68.2 33% 3e-11 33.13 368 P34738.2 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118121 68.2 68.2 69% 3e-11 24.10 363 Q9EVI4.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118112 67.8 67.8 70% 4e-11 23.96 363 Q9EVG6.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118114 66.2 66.2 48% 1e-10 26.15 363 Q9EVE1.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 168386 62.0 62.0 23% 1e-10 34.31 126 Q9AQC8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118117 66.2 66.2 32% 1e-10 29.29 365 Q9EVG9.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118115 65.1 65.1 28% 2e-10 31.15 363 Q9EVH8.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118101 65.1 65.1 32% 3e-10 28.57 363 O85071.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Hapsidospora... NA 5044 65.1 65.1 76% 3e-10 23.88 380 Q12545.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 107806 64.7 64.7 33% 3e-10 27.59 363 P56933.2 RecName: Full=Isopropyl malate dehydrogenase htyC; AltName:... Aspergillus ... NA 41736 64.3 64.3 58% 4e-10 23.02 366 K0E689.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Buchnera aph... NA 118118 63.9 63.9 28% 6e-10 32.26 364 Q9EVI7.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Campylobacte... NA 192222 62.8 62.8 90% 1e-09 24.06 358 Q9PLW0.1 RecName: Full=3-isopropylmalate dehydrogenase; AltName:... Campylobacte... NA 195099 62.8 62.8 90% 2e-09 24.44 358 Q5HS77.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Zygosaccharo... NA 559307 60.1 60.1 27% 1e-08 34.92 362 Q96WI0.1 RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH;... Zygosaccharo... NA 4954 58.9 58.9 33% 2e-08 30.46 362 Q9P3Y0.1 RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic;... Dictyosteliu... NA 44689 45.4 45.4 73% 7e-04 22.49 412 Q75JR3.1 Alignments: >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Coxiella burnetii RSA 493] Sequence ID: Q9ZH99.1 Length: 427 Range 1: 1 to 427 Score:867 bits(2239), Expect:0.0, Method:Compositional matrix adjust., Identities:427/427(100%), Positives:427/427(100%), Gaps:0/427(0%) Query 1 MTELTGVSIVTYQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVD 60 MTELTGVSIVTYQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVD Sbjct 1 MTELTGVSIVTYQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVD 60 Query 61 AAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGG 120 AAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGG Sbjct 61 AAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGG 120 Query 121 IRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSP 180 IRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSP Sbjct 121 IRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSP 180 Query 181 EAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHK 240 EAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHK Sbjct 181 EAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHK 240 Query 241 GNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQIL 300 GNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQIL Sbjct 241 GNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQIL 300 Query 301 LRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDK 360 LRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDK Sbjct 301 LRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDK 360 Query 361 VNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGK 420 VNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGK Sbjct 361 VNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGK 420 Query 421 AIIKHIL 427 AIIKHIL Sbjct 421 AIIKHIL 427 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Pseudomonas aeruginosa UCBPP-PA14] Sequence ID: Q02NB5.1 Length: 418 Range 1: 3 to 418 Score:670 bits(1728), Expect:0.0, Method:Compositional matrix adjust., Identities:321/416(77%), Positives:363/416(87%), Gaps:1/416(0%) Query 12 YQHIKVPSQGEKITVNKAV-LEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGK 70 YQ I+VP+ G+KITVN + L VP PIIPFIEGDGIG+DI+PVM VVDAAVEK+Y G+ Sbjct 3 YQKIQVPATGDKITVNADMSLSVPKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGE 62 Query 71 RKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQ 130 RKI WME+YAGEKAT+VY +D WLP ETL+A+++Y V+IKGPLTTPVGGGIRSLNVALRQ Sbjct 63 RKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYVVSIKGPLTTPVGGGIRSLNVALRQ 122 Query 131 QLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQ 190 QLDLYVC RPVR+F GVPSPVK P V+MVIFRENSEDIYAG+EW AGSPEA K+I FL Sbjct 123 QLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLT 182 Query 191 NEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGA 250 EMGVKKIRF E GIGIKPVS+EGT RLVR+A+QYA+DNDR SVTLVHKGNIMKFTEGA Sbjct 183 EEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGA 242 Query 251 FKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIA 310 FKDWGYEVA EFGA+ LDGGPW F+NPKTG+ + +KDVIADA LQQILLRPAEY VIA Sbjct 243 FKDWGYEVARDEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIA 302 Query 311 TLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSA 370 TLNLNGDY+SDALAAEVGGIGIAPGANLSD+V +FEATHGTAPKYAGQDKVNPGSLILSA Sbjct 303 TLNLNGDYLSDALAAEVGGIGIAPGANLSDSVAMFEATHGTAPKYAGQDKVNPGSLILSA 362 Query 371 EMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 EMMLR++GW EAADL+++G GAI +KTVTYDF RLM GA +S S+FG A+I + Sbjct 363 EMMLRHMGWTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Escherichia coli K-12] Sequence ID: P08200.1 Length: 416 Range 1: 7 to 416 Score:648 bits(1672), Expect:0.0, Method:Compositional matrix adjust., Identities:308/410(75%), Positives:355/410(86%), Gaps:0/410(0%) Query 17 VPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWM 76 VP+QG+KIT+ L VP+ PIIP+IEGDGIG+D+ P M VVDAAVEK+Y G+RKI WM Sbjct 7 VPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWM 66 Query 77 EIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYV 136 EIY GEK+T+VYG+D WLP ETL+ I+EY+VAIKGPLTTPVGGGIRSLNVALRQ+LDLY+ Sbjct 67 EIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYI 126 Query 137 CLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVK 196 CLRPVRY+ G PSPVK PE +MVIFRENSEDIYAGIEW A S +A K+I FL+ EMGVK Sbjct 127 CLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK 186 Query 197 KIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGY 256 KIRFPE GIGIKP S+EGT RLVR AI+YAI NDRDSVTLVHKGNIMKFTEGAFKDWGY Sbjct 187 KIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGY 246 Query 257 EVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNG 316 ++A +EFG + +DGGPW +NP TG++I IKDVIADAFLQQILLRPAEY VIA +NLNG Sbjct 247 QLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNG 306 Query 317 DYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 DYISDALAA+VGGIGIAPGAN+ D LFEATHGTAPKYAGQDKVNPGS+ILSAEMMLR+ Sbjct 307 DYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRH 366 Query 377 LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +GW EAADL+V+G+EGAI +KTVTYDF RLM GAK + S+FG AII+++ Sbjct 367 MGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 >RecName: Full=Isocitrate dehydrogenase [NADP] 1; AltName: Full=IDH-I; AltName: Full=IDP-1; AltName: Full=NADP(+)-specific ICDH 1; AltName: Full=Oxalosuccinate decarboxylase 1 [Colwellia maris] Sequence ID: P41560.2 Length: 415 Range 1: 5 to 415 Score:613 bits(1581), Expect:0.0, Method:Compositional matrix adjust., Identities:293/412(71%), Positives:347/412(84%), Gaps:1/412(0%) Query 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74 I +P+ G+KIT L VP+ PIIP+IEGDGIG+D+ P M VV+AAV K+Y G RKIE Sbjct 5 IIIPTTGDKITFIDGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIE 64 Query 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134 W+E+YAGEKATK+Y + WLP+ETL ++EY+V+IKGPLTTPVGGG+ SLNVA+RQ LDL Sbjct 65 WLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQMLDL 124 Query 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194 YVC RPV++FTGVPSPVK P +V+MVIFREN+EDIYAGIE+ AGS +A +I FL EMG Sbjct 125 YVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMG 184 Query 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254 IRF E GIGIKPVSKEG+ RLVR+AIQYAIDN++DSVTLVHKGNIMKFTEGAFKDW Sbjct 185 ASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDW 244 Query 255 GYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314 GYE+A++EFGA L GGPW +NP TG++I IKDVIADA LQQ+LLRPAEYSVIATLNL Sbjct 245 GYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNL 304 Query 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374 NGDY+SDALAA+VGGIGIAPGANL D V +FEATHGTAPKYAG++KVNPGS+ILSAEMML Sbjct 305 NGDYLSDALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSAEMML 364 Query 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 R++GW E ADL+++G+ GAI++KTVTYDF RLM A VS S FG II H+ Sbjct 365 RHMGWLE-ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Helicobacter pylori 26695] Sequence ID: P56063.1 Length: 425 Range 1: 8 to 425 Score:600 bits(1548), Expect:0.0, Method:Compositional matrix adjust., Identities:288/419(69%), Positives:348/419(83%), Gaps:8/419(1%) Query 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74 ++ P +GE+IT+ L VP+ PIIPFIEGDGIG DI P M VVD+AV+K+Y G++KI Sbjct 8 LQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIA 67 Query 75 WMEIYAGEKATKVYG-------KDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVA 127 W E++ GEK + + ++ WL +T+EAI Y+V+IKGPLTTP+G G RSLNVA Sbjct 68 WYEVFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVA 127 Query 128 LRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLIN 187 LRQ++DLYVCLRPVR++ G PSPVK P+KV+MVIFRENSEDIYAGIEW GS EA KLI+ Sbjct 128 LRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIH 186 Query 188 FLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFT 247 FLQNE+ VKKIRFPE++GIG+KP+SKEGT RLVR+AI+YAIDND+ SVT VHKGNIMK+T Sbjct 187 FLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYT 246 Query 248 EGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYS 307 EGAF WGY +A KEF A+ +D GPW +NPK G++I IKD+IADAFLQQILLRP+EYS Sbjct 247 EGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYS 306 Query 308 VIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLI 367 VIAT+NLNGDYISDALAA VGGIGIAPGANL+DTVG+FEATHGTAPKYAG DKVNPGS+I Sbjct 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366 Query 368 LSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 LSAEMMLR++GW EAADL+V +E AI+SK VTYDFARLM GAKEV S+F +I+++ Sbjct 367 LSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Helicobacter pylori J99] Sequence ID: Q9ZN36.1 Length: 425 Range 1: 8 to 425 Score:600 bits(1547), Expect:0.0, Method:Compositional matrix adjust., Identities:288/419(69%), Positives:349/419(83%), Gaps:8/419(1%) Query 15 IKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74 ++ P +GE+IT+ L VP+ PIIPFIEGDGIG DI P M VVD+AV+K+Y G++KI Sbjct 8 LQKPKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIA 67 Query 75 WMEIYAGEKATKVYG-------KDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVA 127 W E++ GEK + + ++ WL +T+EAI Y+V+IKGPLTTP+G G RSLNVA Sbjct 68 WYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVA 127 Query 128 LRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLIN 187 LRQ++DLYVCLRPVR++ G PSPVK P+KV+MVIFRENSEDIYAGIEW GS EA KLI+ Sbjct 128 LRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIH 186 Query 188 FLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFT 247 FLQNE+ V+KIRFPE++G+GIKP+SKEGT RLVR+AI+YAIDND+ SVT VHKGNIMK+T Sbjct 187 FLQNELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYT 246 Query 248 EGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYS 307 EGAF WGY +A KEF A+ +D GPW +NPKTG++I IKD+IADAFLQQILLRP+EYS Sbjct 247 EGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYS 306 Query 308 VIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLI 367 VIAT+NLNGDYISDALAA VGGIGIAPGANL+DTVG+FEATHGTAPKYAG DKVNPGS+I Sbjct 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366 Query 368 LSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 LSAEMMLR++GW EAADL+V +E AI+SK VTYDFARLM GAKEV S+F +I+++ Sbjct 367 LSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P39126.1 Length: 423 Range 1: 2 to 422 Score:554 bits(1427), Expect:0.0, Method:Compositional matrix adjust., Identities:282/426(66%), Positives:330/426(77%), Gaps:23/426(5%) Query 19 SQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEI 78 +QGEKITV+ VL VP+ PIIPFIEGDG G DI V++AAVEK+Y G++KI W E+ Sbjct 2 AQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEV 61 Query 79 YAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCL 138 YAGEKA G+ WLP ETL+ I+EY +AIKGPLTTPVGGGIRSLNVALRQ+LDL+VCL Sbjct 62 YAGEKAYNKTGE--WLPAETLDVIREYFIAIKGPLTTPVGGGIRSLNVALRQELDLFVCL 119 Query 139 RPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKI 198 RPVRYFTGVPSPVK PE +MVIFREN+EDIYAGIE+ GS E KLI+FLQNE+ V KI Sbjct 120 RPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKI 179 Query 199 RFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEV 258 RFPET+GIGIKPVS+EGTSRLVR AI YAI++ R SVTLVHKGNIMKFTEGAFK+WGYE+ Sbjct 180 RFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYEL 239 Query 259 AVKEFGAKPLDGGPWHVFENPKTGQ----------------KITIKDVIADAFLQQILLR 302 A KE+G K W ++ Q KI IKD IAD FLQQIL R Sbjct 240 AEKEYGDKVF---TWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTR 296 Query 303 PAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG--LFEATHGTAPKYAGQDK 360 P E+ V+AT+NLNGDYISDALAA+VGGIGIAPGAN++ G +FEATHGTAPKYAG DK Sbjct 297 PNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDK 356 Query 361 VNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGK 420 VNP S+ILS ++L +LGW EAADLV++ +E I SK VTYDFARLM GA EV S+FG+ Sbjct 357 VNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIASKVVTYDFARLMDGATEVKCSEFGE 416 Query 421 AIIKHI 426 +IK++ Sbjct 417 ELIKNM 422 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus epidermidis RP62A] Sequence ID: Q5HNL1.1 Length: 422 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus epidermidis ATCC 12228] Sequence ID: Q8CNX4.1 Length: 422 Range 1: 3 to 421 Score:542 bits(1397), Expect:0.0, Method:Compositional matrix adjust., Identities:278/424(66%), Positives:323/424(76%), Gaps:23/424(5%) Query 21 GEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYA 80 EKIT +K L VP+ PIIPFI GDGIG DI V+DAAVEK+Y G+++IEW E+ A Sbjct 3 AEKITQSKDGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLA 62 Query 81 GEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRP 140 G+KA G+ WLP ETLE IKEY +A+KGPLTTP+GGGIRSLNVALRQ+LDL+ CLRP Sbjct 63 GQKAYDETGE--WLPQETLETIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP 120 Query 141 VRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRF 200 VR+F GVPSPVK PE V+MVIFREN+EDIYAGIE+ G+ E K+I+FLQNEMG IRF Sbjct 121 VRWFKGVPSPVKRPEDVDMVIFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRF 180 Query 201 PETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAV 260 PET+GIGIKPVSKEGT RLVR AIQYA+DN+R SVTLVHKGNIMKFTEG+FK WGY++A Sbjct 181 PETSGIGIKPVSKEGTERLVRAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAH 240 Query 261 KEFGAKPLDGGPWHVFE--------------NPKTGQ--KITIKDVIADAFLQQILLRPA 304 EFG K W ++ K Q KI IKD IAD FLQQIL RPA Sbjct 241 NEFGDKVF---TWQQYDEIVEQKGKDAANEAQSKAEQEGKIIIKDSIADIFLQQILTRPA 297 Query 305 EYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG--LFEATHGTAPKYAGQDKVN 362 E+ V+AT+NLNGDYISDALAA+VGGIGIAPGAN++ G +FEATHGTAPKYAG +KVN Sbjct 298 EHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVN 357 Query 363 PGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 P S ILS+ +ML +LGW+EAAD + IE I SK VTYDFARLM GAKEVSTS F + Sbjct 358 PSSEILSSVLMLEHLGWQEAADKITDSIEATIASKIVTYDFARLMDGAKEVSTSDFADEL 417 Query 423 IKHI 426 IK+I Sbjct 418 IKNI 421 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus aureus subsp. aureus MSSA476] Sequence ID: Q6G8N2.1 Length: 422 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus aureus subsp. aureus MW2] Sequence ID: Q8NW61.1 Length: 422 Range 1: 3 to 421 Score:539 bits(1388), Expect:0.0, Method:Compositional matrix adjust., Identities:273/424(64%), Positives:324/424(76%), Gaps:23/424(5%) Query 21 GEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYA 80 EKIT L VP+ PIIPFI GDGIG DI V+DAAVEK+Y G+++IEW E+ A Sbjct 3 AEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLA 62 Query 81 GEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRP 140 G+KA G+ WLP ETL+ IKEY +A+KGPLTTP+GGGIRSLNVALRQ+LDL+ CLRP Sbjct 63 GQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP 120 Query 141 VRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRF 200 VR+F GVPSPVK P+ V+MVIFREN+EDIYAGIE+ G+ E K+I+FLQNEMG IRF Sbjct 121 VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF 180 Query 201 PETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAV 260 PET+GIGIKPVSKEGT RLVR AIQYAIDN+R SVTLVHKGNIMKFTEG+FK WGY++A+ Sbjct 181 PETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL 240 Query 261 KEFGAKPLDGGPWHVFEN--PKTGQ--------------KITIKDVIADAFLQQILLRPA 304 EFG + W ++ K G+ KI IKD IAD FLQQIL RPA Sbjct 241 SEFGDQVF---TWQQYDEIVEKEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPA 297 Query 305 EYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG--LFEATHGTAPKYAGQDKVN 362 E+ V+AT+NLNGDYISDALAA+VGGIGIAPGAN++ G +FEATHGTAPKYAG +KVN Sbjct 298 EHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVN 357 Query 363 PGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 P S+ILS+ +ML +LGW+EAAD + IE I SK VTYDFARLM GA+EVSTS F + Sbjct 358 PSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADEL 417 Query 423 IKHI 426 IK++ Sbjct 418 IKNL 421 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus aureus subsp. aureus MRSA252] Sequence ID: Q6GG12.1 Length: 422 Range 1: 3 to 421 Score:539 bits(1388), Expect:0.0, Method:Compositional matrix adjust., Identities:273/424(64%), Positives:324/424(76%), Gaps:23/424(5%) Query 21 GEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYA 80 EKIT L VP+ PIIPFI GDGIG DI V+DAAVEK+Y G+++IEW E+ A Sbjct 3 AEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLA 62 Query 81 GEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRP 140 G+KA G+ WLP ETL+ IKEY +A+KGPLTTP+GGGIRSLNVALRQ+LDL+ CLRP Sbjct 63 GQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP 120 Query 141 VRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRF 200 VR+F GVPSPVK P+ V+MVIFREN+EDIYAGIE+ G+ E K+I+FLQNEMG IRF Sbjct 121 VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF 180 Query 201 PETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAV 260 PET+GIGIKPVSKEGT RLVR AIQYAIDN+R SVTLVHKGNIMKFTEG+FK WGY++A+ Sbjct 181 PETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL 240 Query 261 KEFGAKPLDGGPWHVFEN--PKTGQ--------------KITIKDVIADAFLQQILLRPA 304 EFG + W ++ K G+ KI IKD IAD FLQQIL RPA Sbjct 241 TEFGDQVF---TWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPA 297 Query 305 EYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG--LFEATHGTAPKYAGQDKVN 362 E+ V+AT+NLNGDYISDALAA+VGGIGIAPGAN++ G +FEATHGTAPKYAG +KVN Sbjct 298 EHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVN 357 Query 363 PGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 P S+ILS+ +ML +LGW+EAAD + IE I SK VTYDFARLM GA+EVSTS F + Sbjct 358 PSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADEL 417 Query 423 IKHI 426 IK++ Sbjct 418 IKNL 421 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus aureus subsp. aureus Mu50] Sequence ID: P65099.1 Length: 422 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus aureus subsp. aureus N315] Sequence ID: P99167.1 Length: 422 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Staphylococcus aureus subsp. aureus COL] Sequence ID: Q5HF79.1 Length: 422 Range 1: 3 to 421 Score:538 bits(1386), Expect:0.0, Method:Compositional matrix adjust., Identities:272/424(64%), Positives:322/424(75%), Gaps:23/424(5%) Query 21 GEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYA 80 EKIT L VP+ PIIPFI GDGIG DI V+DAAVEK+Y G+++IEW E+ A Sbjct 3 AEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLA 62 Query 81 GEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRP 140 G+KA G+ WLP ETL+ IKEY +A+KGPLTTP+GGGIRSLNVALRQ+LDL+ CLRP Sbjct 63 GQKAFDTTGE--WLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP 120 Query 141 VRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRF 200 VR+F GVPSPVK P+ V+MVIFREN+EDIYAGIE+ G+ E K+I+FLQNEMG IRF Sbjct 121 VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF 180 Query 201 PETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAV 260 PET+GIGIKPVSKEGT RLVR AIQYAIDN+R SVTLVHKGNIMKFTEG+FK WGY++A+ Sbjct 181 PETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL 240 Query 261 KEFGAKPLDGGPWHVF----------------ENPKTGQKITIKDVIADAFLQQILLRPA 304 EFG + W + E + KI IKD IAD FLQQIL RPA Sbjct 241 SEFGDQVF---TWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPA 297 Query 305 EYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG--LFEATHGTAPKYAGQDKVN 362 E+ V+AT+NLNGDYISDALAA+VGGIGIAPGAN++ G +FEATHGTAPKYAG +KVN Sbjct 298 EHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVN 357 Query 363 PGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 P S+ILS+ +ML +LGW+EAAD + IE I SK VTYDFARLM GA+EVSTS F + Sbjct 358 PSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADEL 417 Query 423 IKHI 426 IK++ Sbjct 418 IKNL 421 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Archaeoglobus fulgidus DSM 4304] Sequence ID: O29610.1 Length: 412 Range 1: 1 to 409 Score:474 bits(1219), Expect:2e-165, Method:Compositional matrix adjust., Identities:240/418(57%), Positives:306/418(73%), Gaps:10/418(2%) Query 10 VTYQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAG 69 + Y+ +K P GEKI L VPD PIIP+ EGDGIG D+ P V+DAA +K Sbjct 1 MQYEKVKPPENGEKIRYENGKLIVPDNPIIPYFEGDGIGKDVVPAAIRVLDAAADKI--- 57 Query 70 KRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALR 129 +++ W ++YAGE A K+YG N+LPD+TL AIKE++VA+KGPLTTPVGGG RSLNV +R Sbjct 58 GKEVVWFQVYAGEDAYKLYG--NYLPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIR 115 Query 130 QQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFL 189 Q LDLY +RPV Y GVPSP+K PEKVN VIFREN+ED+YAGIEWP GS EA+KLI FL Sbjct 116 QVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFL 175 Query 190 QNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEG 249 +NE GV IR E +GIGIKP+S+ T RLVR AI+YAI+N+R SVTLVHKGNIMK+TEG Sbjct 176 KNEFGV-TIR--EDSGIGIKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEG 232 Query 250 AFKDWGYEVAVKEFGAKPL-DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSV 308 AF+DWGYEVA +EFG + + W + + KI +KD IAD QQIL R EY V Sbjct 233 AFRDWGYEVAKQEFGEYCITEDELWDKYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDV 292 Query 309 IATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLIL 368 IA NLNGDY+SDA AA +GG+GIAPG+N+ D +G+FE HG+APKYAGQ+KVNP + IL Sbjct 293 IALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIGVFEPVHGSAPKYAGQNKVNPTAEIL 352 Query 369 SAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + +M Y+GWK+A++++ + +E I S VTYD R M G K V T +F +A+++++ Sbjct 353 TGALMFEYIGWKDASEMIKKAVEMTISSGIVTYDIHRHMGGTK-VGTREFAEAVVENL 409 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Nostoc sp. PCC 7120 = FACHB-418] Sequence ID: P50214.1 Length: 473 Range 1: 2 to 472 Score:471 bits(1212), Expect:2e-163, Method:Compositional matrix adjust., Identities:245/473(52%), Positives:309/473(65%), Gaps:60/473(12%) Query 12 YQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKR 71 Y I P+ GEKIT VPD PIIPFI GDG GIDI P + V+DAAV K+Y GKR Sbjct 2 YNKITPPTTGEKITFKNGEPVVPDNPIIPFIRGDGTGIDIWPATEKVLDAAVAKAYQGKR 61 Query 72 KIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQ 131 KI W ++YAG++A +YG +LP++TL AI+EY VAIKGPLTTPVGGGIRSLNVALRQ Sbjct 62 KISWFKVYAGDEACDLYGTYQYLPEDTLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQI 121 Query 132 LDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQN 191 DLY C+RP RY+ G PSP K PEK++++++REN+EDIY GIEW GS +LI+ L Sbjct 122 FDLYACVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIYLGIEWKQGSEIGDRLISILNK 181 Query 192 EM-------GVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAID--NDRDSVTLVHKGN 242 E+ G K+I P +GIGIKP+SK G+ RLVRRAI++A+ D+ VTLVHKGN Sbjct 182 ELIPATPEHGKKQI--PLDSGIGIKPISKTGSQRLVRRAIKHALTLPKDKQQVTLVHKGN 239 Query 243 IMKFTEGAFKDWGYEVAVKEF--------------------------GAKPLDGG----- 271 IMK+TEGAF+DWGYE+A EF A+ +D G Sbjct 240 IMKYTEGAFRDWGYELATSEFRQETVTERESWILSNKEKNPNISLEDNARQIDPGFDALT 299 Query 272 -----------------PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314 W N K +K+ + D IAD+ QQI RP EYS++AT+NL Sbjct 300 PEKKAQIVKEVETVLNSIWESHGNGKWKEKVLVNDRIADSIFQQIQTRPDEYSILATMNL 359 Query 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374 NGDY+SDA AA VGG+G+ PGAN+ D+ +FEATHGTAPK+AG D++NPGS+ILS MML Sbjct 360 NGDYLSDAAAAIVGGLGMGPGANIGDSCAVFEATHGTAPKHAGLDRINPGSVILSGVMML 419 Query 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKE-VSTSQFGKAIIKHI 426 Y+GW+EAADL+ +G+ AI + VTYD ARL+ E + S+F AIIKH Sbjct 420 EYMGWQEAADLIKKGLSDAIANSQVTYDLARLLEPPVEPLKCSEFADAIIKHF 472 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Streptococcus mutans UA159] Sequence ID: Q59940.2 Length: 393 Range 1: 3 to 393 Score:462 bits(1188), Expect:5e-161, Method:Compositional matrix adjust., Identities:224/407(55%), Positives:299/407(73%), Gaps:18/407(4%) Query 22 EKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAG 81 EK++ + L+VPD+P+IP+IEGDG+G DI + V D A+ K Y G +++ W E+ AG Sbjct 3 EKVSFEEGKLQVPDKPVIPYIEGDGVGQDIWKNAQIVFDKAIAKVYGGHKQVIWREVLAG 62 Query 82 EKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPV 141 +KA G NWLP+ETLE IK + +AIKGPL TPVGGGIRSLNVALRQ+LDL+ C+RPV Sbjct 63 KKAYNETG--NWLPNETLEIIKTHLLAIKGPLETPVGGGIRSLNVALRQELDLFACVRPV 120 Query 142 RYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFP 201 RYF GVPSP+K PEK + IFREN+EDIYAGIEW AG+ E K+INFLQ++M VKKIRFP Sbjct 121 RYFKGVPSPLKHPEKTAITIFRENTEDIYAGIEWNAGTAEVQKVINFLQDDMQVKKIRFP 180 Query 202 ETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVK 261 +++ IGIKP+S EG+ RL+R AI+YA+ N+ VTLVHKGNI KFTEG F+ WGYE+A + Sbjct 181 KSSSIGIKPISIEGSQRLIRAAIEYALANNLTKVTLVHKGNIQKFTEGGFRKWGYELAKR 240 Query 262 EFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISD 321 E+ A+ G ++ + D+IAD FLQQILL+P + V+A NLNGDY SD Sbjct 241 EYAAELASG-------------QLVVDDIIADNFLQQILLKPERFDVVALTNLNGDYASD 287 Query 322 ALAAEVGGIGIAPGANLSDTVG--LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGW 379 ALAA+VGGIGI+PGAN++ G +FEATHGTAP AGQD NP S++LS M+ Y+GW Sbjct 288 ALAAQVGGIGISPGANINYQTGHAIFEATHGTAPDIAGQDLANPSSVLLSGCMLFDYIGW 347 Query 380 KEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + +DL+++ +E AI + VT DFA+ + G + ++T QF + ++ ++ Sbjct 348 SKVSDLIMKAVEKAIANGQVTIDFAKEL-GVEALTTRQFSEVLLTYL 393 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Streptococcus salivarius] Sequence ID: Q59985.1 Length: 391 Range 1: 2 to 388 Score:461 bits(1186), Expect:7e-161, Method:Compositional matrix adjust., Identities:234/405(58%), Positives:285/405(70%), Gaps:20/405(4%) Query 21 GEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYA 80 EKI + L+V DRPIIPFIEGDG+G DI + + D AVE +Y GKR IEW E+ A Sbjct 2 AEKIVMKNGQLQVSDRPIIPFIEGDGVGHDIWKNAQAIFDKAVEVAYEGKRHIEWQELLA 61 Query 81 GEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRP 140 G+KA G+ WLP ETLEAI+E VAIKGPL TPVGGGIRSLNVALRQ+LDLY C+RP Sbjct 62 GKKAYDKTGE--WLPKETLEAIRESLVAIKGPLETPVGGGIRSLNVALRQELDLYACVRP 119 Query 141 VRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRF 200 VRYF GV SP+K PEK N+ IFREN+EDIYAGIEW AG+ + ++I FLQ EM V KIRF Sbjct 120 VRYFDGVASPLKEPEKTNITIFRENTEDIYAGIEWEAGTADVKRVIEFLQTEMNVNKIRF 179 Query 201 PETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAV 260 PE++ IGIKP+S EG+ RL+R AI YA+ N+ VTLVHKGNI KFTEG F+ WGYEVA Sbjct 180 PESSSIGIKPISIEGSKRLIRSAIDYALKNNLKKVTLVHKGNIQKFTEGGFRKWGYEVAQ 239 Query 261 KEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYIS 320 +++ + L G ++ I D+IAD FLQQILL P ++ V+A NLNGDY S Sbjct 240 EDYKEELLAG-------------RLEINDIIADNFLQQILLNPEKFDVVALTNLNGDYAS 286 Query 321 DALAAEVGGIGIAPGANLSDTVG--LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG 378 DALAA+VGGIGI+PGAN++ G +FEATHGTAP A QDK NP S++LS M+L Y+G Sbjct 287 DALAAQVGGIGISPGANINYQTGHAIFEATHGTAPDIADQDKANPCSVLLSGCMLLDYIG 346 Query 379 WKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 W EAA L+ IE ++ T D A G + STS F I+ Sbjct 347 WTEAAQLITSAIEKTFKADIFTADLA---FGKQAYSTSAFSNQIL 388 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=ICDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Haloferax volcanii DS2] Sequence ID: D4GU92.1 Length: 419 Range 1: 1 to 415 Score:457 bits(1177), Expect:5e-159, Method:Compositional matrix adjust., Identities:222/420(53%), Positives:295/420(70%), Gaps:8/420(1%) Query 10 VTYQHIKVPSQGEKITVNKAV--LEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSY 67 ++Y I+VP GEKITV++ L VPD PIIP I GDGIG D+ P + V+DAA E Sbjct 1 MSYDQIEVPDDGEKITVDEETGELSVPDNPIIPIIHGDGIGTDVGPAAQKVLDAAAE--- 57 Query 68 AGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVA 127 A R + WM +YAG A Y D LP++T+ AI+ ++VAIKGPLTTPVG G RSLNVA Sbjct 58 ATGRSVSWMRVYAGSSARDKY--DENLPEDTVSAIRNHRVAIKGPLTTPVGAGFRSLNVA 115 Query 128 LRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLIN 187 LR++LDLY +RP + GVPSPVK P ++MV FREN+ED+YAGIEW AG+ E K+ Sbjct 116 LRKKLDLYANVRPTYHLDGVPSPVKNPSAMDMVTFRENTEDVYAGIEWEAGTDEVQKVKE 175 Query 188 FLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFT 247 F++ EMG + GIGIKP+++ GT RLVR AI+YA++NDR SVTLVHKGNIMKFT Sbjct 176 FVEEEMGADGVIHDGPVGIGIKPITEFGTKRLVREAIEYALENDRPSVTLVHKGNIMKFT 235 Query 248 EGAFKDWGYEVAVKEFGAKPL-DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEY 306 EGAF+DWGYE+A +EFG + + W ++ + K+ +KD IAD LQQ+L R A+Y Sbjct 236 EGAFRDWGYELAEEEFGDVTITEDELWEEYDGERPEDKVVVKDRIADNMLQQLLTRTADY 295 Query 307 SVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSL 366 VIAT+NLNGDY+SDA A++GG+GIAPGAN + + L E HG+APKYAG+DKVNP ++ Sbjct 296 DVIATMNLNGDYMSDAAGAQIGGLGIAPGANFGEGLCLAEPVHGSAPKYAGEDKVNPTAM 355 Query 367 ILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ILS +M Y+GWK+A L+ +E I VTYD R + G +++TS++ ++++I Sbjct 356 ILSGRLMFEYMGWKDAGKLIRDAVEKTISDGDVTYDLERQIEGGNKLATSEYADKVVENI 415 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Synechocystis sp. PCC 6803 substr. Kazusa] Sequence ID: P80046.2 Length: 475 Range 1: 2 to 473 Score:453 bits(1165), Expect:2e-156, Method:Compositional matrix adjust., Identities:234/474(49%), Positives:309/474(65%), Gaps:61/474(12%) Query 12 YQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKR 71 Y+ ++ PS G KIT VP+ PIIP+I GDG G+DI P + V++AA+ K+Y G+ Sbjct 2 YEKLQPPSVGSKITFVAGKPVVPNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGRE 61 Query 72 KIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQ 131 +I W ++YAG++A ++YG P++TL AIKEY VAIKGPLTTPVGGGIRSLNVALRQ Sbjct 62 EINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQI 121 Query 132 LDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQN 191 DLY C+RP RY+ G PSP KTPEK++++++REN+EDIY GIEW G+ A KLI +L + Sbjct 122 FDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLND 181 Query 192 E-------MGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYA--IDNDRDSVTLVHKGN 242 E +G K+IR +GIGIKP+SK G+ RLVRRAI +A + + VTLVHKGN Sbjct 182 ELIPTTPALGKKQIRL--DSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGN 239 Query 243 IMKFTEGAFKDWGYEVAVKEFGAKPL-----------DGGP------------------- 272 IMKFTEG F+DWGYE+A EF A+ + + P Sbjct 240 IMKFTEGPFRDWGYELATTEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTLT 299 Query 273 ------------------WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNL 314 W N + +K+ + D IAD+ QQI RP EYS++AT+NL Sbjct 300 EEKQAVIKQEVEQVLNSIWESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMNL 359 Query 315 NGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374 NGDY+SDA AA VGG+G+ PGAN+ D+ +FEATHGTAPK+AG D++NPGS+ILS MML Sbjct 360 NGDYLSDAAAAVVGGLGMGPGANIGDSAAIFEATHGTAPKHAGLDRINPGSVILSGVMML 419 Query 375 RYLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGA--KEVSTSQFGKAIIKHI 426 ++GW+EAADL+ +GI AI ++ VTYD ARLM K + S+F +AI+ H Sbjct 420 EFMGWQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSHF 473 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Caldococcus noboribetus] Sequence ID: P96318.2 Length: 429 Range 1: 6 to 418 Score:372 bits(954), Expect:4e-125, Method:Compositional matrix adjust., Identities:204/419(49%), Positives:274/419(65%), Gaps:8/419(1%) Query 10 VTYQHIKVPSQGEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAG 69 T K PS+G+ L VPD I+ + +GDGIG +I K V+DAAV+K+Y G Sbjct 6 CTADEAKPPSEGQLARFENGKLIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGG 65 Query 70 KRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALR 129 R+I W E+ AGE+A K G + LPD TL+A K +V +KGPLTTPVGGG RSLNV LR Sbjct 66 TRRIVWWEVTAGEEAQKECG--SLLPDGTLQAFKLARVNLKGPLTTPVGGGFRSLNVTLR 123 Query 130 QQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFL 189 LDLY +RPV+++ G P+P PE ++ VIFREN+ED+YAGIEWP SPEA K+ +FL Sbjct 124 MVLDLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFL 182 Query 190 QNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEG 249 + E G++ P+T GIGIKP+SK T R VRRA+++AI N VT++HKGNIMK+TEG Sbjct 183 KKEFGIELT--PDT-GIGIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEG 239 Query 250 AFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQ-KITIKDVIADAFLQQILLRPAEYSV 308 AF+ W Y++ + EF + + K + KI + D IAD LQQI+ RP EY+V Sbjct 240 AFRQWAYDLILSEFRDYVVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNV 299 Query 309 IATLNLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLIL 368 I T NLNGDYISD A VGGIG+A G ++ D + + E HG+APKYAG++ +NP + IL Sbjct 300 IVTPNLNGDYISDEANALVGGIGMAAGLDMGDGIAVAEPVHGSAPKYAGKNVINPTAEIL 359 Query 369 SAEMMLR-YLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 S +L ++GW E LV ++ AI K VTYD AR M G +ST+++ ++ +I Sbjct 360 SGMYLLSDFVGWPEVKLLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYI 418 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Aquifex aeolicus VF5] Sequence ID: O67480.1 Length: 426 Range 1: 17 to 425 Score:351 bits(901), Expect:4e-117, Method:Compositional matrix adjust., Identities:194/417(47%), Positives:267/417(64%), Gaps:14/417(3%) Query 16 KVPSQGEKITVNK-AVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIE 74 ++P +G+ I + + LEVPD PIIPFIEGDGIG +I M +++ AVEK+Y G +KI Sbjct 17 QIPQEGQFIKLKEDKTLEVPDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIY 76 Query 75 WMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDL 134 W+E+ AG+KA + G+ LP ETL+ +KE V IKGPL TPVG G+RS+N ALR+ D Sbjct 77 WVELLAGDKAEEKTGER--LPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDY 134 Query 135 YVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG 194 Y +RPV Y+ G +P+ PE+V++V+FREN++D+YAG+E+ AG+PEA K+ FL EMG Sbjct 135 YSAVRPV-YWMGQATPIPNPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMG 193 Query 195 VKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDW 254 K+ FPE GI +KP+S+ T R VR+A++YA++N++ +V ++ KGNIMK TEGAF +W Sbjct 194 AKEEGFPEDVGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINW 253 Query 255 GYEVAVK-EFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLN 313 +EVA + EF K + P GQ + + VI D L Q++L+P + VI N Sbjct 254 AFEVAEEPEFKGKVVTDPE----AEPGEGQ-VKLTKVITDQMLMQLVLKPEAWDVIIAQN 308 Query 314 LNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMM 373 LNGDY+SD A+ +GG G P N+ D LFE+THGTA AG+ NP SL LS MM Sbjct 309 LNGDYVSDLAASLIGGPGFVPSGNIGDGYALFESTHGTAWDIAGKGIANPLSLTLSGAMM 368 Query 374 LRYLGWKEAADLVVQGIEGAIESKTVTYD----FARLMTGAKEVSTSQFGKAIIKHI 426 L Y+GWKEAA V + + T D F + AK V T +F + I K I Sbjct 369 LEYIGWKEAAQKVYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRI 425 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Thermus thermophilus HB8] Sequence ID: P33197.2 Length: 496 Range 1: 19 to 355 Score:199 bits(505), Expect:2e-57, Method:Compositional matrix adjust., Identities:134/392(34%), Positives:203/392(51%), Gaps:56/392(14%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLP 95 R +I I GDGIG + V++AA K + + AG + G + +P Sbjct 19 RKLITVIPGDGIGPECVEATLKVLEAA-------KAPLAYEVREAGASVFR-RGIASGVP 70 Query 96 DETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 ET+E+I++ +V +KGPL TPVG G +S NV LR+ + Y +RPVR F VP+P Sbjct 71 QETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAG-R 129 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 +++V+ REN ED+YAGIE ++ P A +K +S +G Sbjct 130 GIDLVVVRENVEDLYAGIE----------------------HMQTPSVAQT-LKLISWKG 166 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 + ++VR A + A R V K NIMK EG K +E +E+ Sbjct 167 SEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLK-RAFEQVAQEY------------ 213 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 I +I D Q++ RP ++ VI T N+NGD +SD + +GG+G AP Sbjct 214 -------PDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGLIGGLGFAPS 266 Query 336 ANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIE 395 AN+ + V +FEA HG+APKYAG++ +NP +++LSA MMLRYL ADL+ + +E Sbjct 267 ANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATADLIENALLYTLE 326 Query 396 S-KTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + +T D GAK T+++ +AII+++ Sbjct 327 EGRVLTGDVVGYDRGAK---TTEYTEAIIQNL 355 >RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial; Flags: Precursor [Dictyostelium discoideum] Sequence ID: Q55BI2.1 Length: 354 Range 1: 26 to 348 Score:178 bits(452), Expect:4e-51, Method:Compositional matrix adjust., Identities:124/390(32%), Positives:188/390(48%), Gaps:69/390(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG +I+ +K V A K IEW T V + + E Sbjct 26 VTLIPGDGIGPEISESVKRVFSAV-------KAPIEW--------ETVVVDANTGISKEV 70 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 +E+I + ++ +KGP++TP+G G +SLN+ LR+ +LY +RP +P VN Sbjct 71 IESISKNKIGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPC---LSIPGHKTRYNNVN 127 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 V+ REN+E Y+GIE + VK GV + IK ++KE ++R Sbjct 128 TVVVRENTEGEYSGIE-----NQPVK---------GVAQ---------SIKIITKEASTR 164 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 + A QYA+ N R VT +HK NIMK ++G F EV+ + Sbjct 165 IAHYAFQYALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRY---------------- 208 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 I +++ D Q++L P + V+ NL GD +SD A +GG+G+ P N+ Sbjct 209 ----PSIKYEELTIDNNCMQLVLDPNQMDVMVLPNLYGDIVSDLCAGLIGGLGLTPSGNI 264 Query 339 SDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAI-ES 396 + +FEA HGTAP AG++K NP +LILS+ MMLR+LG A ++ + + E Sbjct 265 GENGSAIFEAVHGTAPDIAGKNKANPTALILSSIMMLRHLGHFHEASIIENAVLNTLTEG 324 Query 397 KTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 K T D S S++ ++K I Sbjct 325 KVKTGDL------GGNSSCSEYTDELVKKI 348 >RecName: Full=Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial; AltName: Full=IDH-V; AltName: Full=Isocitric dehydrogenase 5; AltName: Full=NAD(+)-specific ICDH 5; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q945K7.1 Length: 374 Range 1: 51 to 374 Score:177 bits(449), Expect:2e-50, Method:Compositional matrix adjust., Identities:126/387(33%), Positives:190/387(49%), Gaps:67/387(17%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIK 103 GDGIG +IA +K V A IEW E Y G + ++L E+LE+++ Sbjct 51 GDGIGPEIAESVKKVFTTA-------GVPIEWEEHYVGTEIDP--RTQSFLTWESLESVR 101 Query 104 EYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFR 163 +V +KGP+ TP+G G RSLN+ LR++L+LY +RP G + + V+++ R Sbjct 102 RNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRY---DDVDLITIR 158 Query 164 ENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVR 221 EN+E Y+G+E G E++K+I +++ + R+ Sbjct 159 ENTEGEYSGLEHQVVRGVVESLKII-------------------------TRQASLRVAE 193 Query 222 RAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKT 281 A YA + R+ V+ +HK NIM+ T+G F EVA K Sbjct 194 YAFLYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKY------------------- 234 Query 282 GQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL-SD 340 +IT ++V+ D ++ PA + V+ NL GD ISD A VGG+G+ P N+ D Sbjct 235 -PEITYEEVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSCNIGED 293 Query 341 TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAI-ESKTV 399 V L EA HG+AP AG++ NP +L+LS MMLR+L + E A+ + I I E K Sbjct 294 GVALAEAVHGSAPDIAGKNLANPTALLLSGVMMLRHLKFNEQAEQIHSAIINTIAEGKYR 353 Query 400 TYDFARLMTGAKEVSTSQFGKAIIKHI 426 T D +T++F KAI H+ Sbjct 354 TADL------GGSSTTTEFTKAICDHL 374 >RecName: Full=Homoisocitrate dehydrogenase; Short=HICDH; AltName: Full=Homo(2)-isocitrate/homo(3)-isocitrate dehydrogenase; AltName: Full=Isohomocitrate dehydrogenase; Short=IHDH; AltName: Full=NAD-dependent threo-isohomocitrate dehydrogenase [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q58991.3 Length: 347 Range 1: 4 to 340 Score:175 bits(444), Expect:6e-50, Method:Compositional matrix adjust., Identities:115/399(29%), Positives:190/399(47%), Gaps:73/399(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + IEGDGIG ++ P +++ E E ++ AG + K YG N LP++T Sbjct 4 VCVIEGDGIGKEVIPEAIKILNELGE--------FEIIKGEAGLECLKKYG--NALPEDT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN---VALRQQLDLYVCLRPVRYFTGVPSPVK--- 152 +E KE + + G +T+P G +++ + LR+ LY +RP+ F G+ + Sbjct 54 IEKAKEADIILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIA 112 Query 153 -----TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 + +++VI REN+ED+Y G E R I Sbjct 113 DYEFLNAKNIDIVIIRENTEDLYVGRE------------------------RLENDTAIA 148 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 + ++++G+ R++R A +YAI N+R V+ +HK N+++ T+G F Sbjct 149 ERVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLF---------------- 192 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 VF K I D + D+ ++ P ++ VI T N+ GD +SD +A + Sbjct 193 -----LEVFNEIKKHYNIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGDILSDEASALI 247 Query 328 GGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVV 387 GG+G+AP AN+ D LFE HG+AP AG+ NP + ILS M+ Y+G KE DL+ Sbjct 248 GGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDYIGEKEKGDLIR 307 Query 388 QGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + +K VT D ++ T G I+ +I Sbjct 308 EAVKYCLINKKVTPDL------GGDLKTKDVGDEILNYI 340 >RecName: Full=Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Drosophila melanogaster] Sequence ID: Q9VWH4.1 Length: 377 Range 1: 50 to 360 Score:175 bits(443), Expect:2e-49, Method:Compositional matrix adjust., Identities:125/375(33%), Positives:184/375(49%), Gaps:74/375(19%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSY-AGKRKIEWMEIYAGEKATKVYGKDN--WLP 95 + I GDGIG +I+ AAV+K + A IEW + T V G D +P Sbjct 50 VTLIPGDGIGPEIS--------AAVQKIFTAANVPIEWEAV----DVTPVRGPDGKFGIP 97 Query 96 DETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 ++++ ++ +KGPL TPVG G RSLN+ALR++ +LY +RP R G + + Sbjct 98 QAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY---D 154 Query 156 KVNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSK 213 V++V REN+E Y+GIE G +++KLI ++ Sbjct 155 DVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI-------------------------TE 189 Query 214 EGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVK----EFGAKPLD 269 E + R+ A QYA +N+R VT+VHK NIM+ ++G F ++A K +F K LD Sbjct 190 EASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLD 249 Query 270 GGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGG 329 ++ +N P +Y V+ NL GD +SD A VGG Sbjct 250 TVCLNMVQN------------------------PGKYDVLVMPNLYGDILSDMCAGLVGG 285 Query 330 IGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQ- 388 +G+ P N+ LFE+ HGTAP AG+D NP +L+LSA MMLR++ AD + + Sbjct 286 LGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERA 345 Query 389 GIEGAIESKTVTYDF 403 E E K +T D Sbjct 346 AFETIKEGKYLTGDL 360 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Rickettsia felis URRWXCal2] Sequence ID: Q4UKR1.2 Length: 483 Range 1: 12 to 341 Score:177 bits(448), Expect:4e-49, Method:Compositional matrix adjust., Identities:121/383(32%), Positives:187/383(48%), Gaps:53/383(13%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIK 103 GDGIG +I + ++ A + ++E +E+ GEK K + + + +E+ E+I+ Sbjct 12 GDGIGPEIMEAVLYILRKA-----EARIRLETIEV--GEKLYKKH-YTSGISEESWESIQ 63 Query 104 EYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFR 163 + +K P+TTP GGG +SLNV +R+ L L+ +RP F P + +N+ I R Sbjct 64 RTGIILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFH--PFTMTLHPHLNLTIIR 121 Query 164 ENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRA 223 EN ED+YAGIE+ R IK +S G +++R A Sbjct 122 ENEEDLYAGIEY-----------------------RQTHNMYESIKLISHTGCEKIIRYA 158 Query 224 IQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQ 283 +YA+ N+R VT + K NIMKF++G F E+A KE+ Sbjct 159 FEYAVKNNRKKVTCLSKDNIMKFSDGVFHKIFNEIA-KEY-------------------P 198 Query 284 KITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG 343 +I + I D ++ +P + VI T NL GD ISD A G +G+A AN+ Sbjct 199 QINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSANIGQHYA 258 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDF 403 +FEA HG+AP AG+D NP L+ +A MML ++G + A L+ + IE T D Sbjct 259 MFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIASLIENAWKKTIEDGVHTADI 318 Query 404 ARLMTGAKEVSTSQFGKAIIKHI 426 +K+V T +F + + K + Sbjct 319 YNEQNSSKKVGTKEFAEEVTKRL 341 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Macaca fascicularis] Sequence ID: Q28480.2 Length: 347 Range 1: 15 to 326 Score:172 bits(437), Expect:6e-49, Method:Compositional matrix adjust., Identities:119/369(32%), Positives:183/369(49%), Gaps:61/369(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKD-NWL-PD 96 + I GDGIG +I+ + + DAA K I+W E T + G W+ P Sbjct 15 VTLIPGDGIGPEISAAVMKIFDAA-------KAPIQWEE----RNVTAIQGPGGKWMIPS 63 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 E E++ + ++ +KGPL TP+ G S+N+ LR+ DLY +RP G +P Sbjct 64 EAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---D 120 Query 157 VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 VN+V REN+E Y+GIE V + +Q+ IK +++ G+ Sbjct 121 VNIVTIRENTEGEYSGIEH-------VIVDGVVQS----------------IKLITEGGS 157 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ A +YA +N R +VT VHK NIM+ ++G F EVA Sbjct 158 KRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA----------------- 200 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 EN K I ++ D ++ P+++ V+ NL GD +SD A +GG+G+ P Sbjct 201 ENCK---DIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSG 257 Query 337 NL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-WKEAADLVVQGIEGAI 394 N+ ++ V +FE+ HGTAP AG+D NP +L+LSA MMLR++G + AA + Sbjct 258 NIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIK 317 Query 395 ESKTVTYDF 403 + K++T D Sbjct 318 DGKSLTKDL 326 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Mus musculus] Sequence ID: Q9D6R2.1 Length: 366 Range 1: 34 to 345 Score:172 bits(436), Expect:2e-48, Method:Compositional matrix adjust., Identities:119/369(32%), Positives:183/369(49%), Gaps:61/369(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKD-NWL-PD 96 + I GDGIG +I+ + + DAA K I+W E T + G W+ P Sbjct 34 VTLIPGDGIGPEISASVMKIFDAA-------KAPIQWEE----RNVTAIQGPGGKWMIPP 82 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 E E++ + ++ +KGPL TP+ G S+N+ LR+ DLY +RP G +P Sbjct 83 EAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---D 139 Query 157 VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 VN+V REN+E Y+GIE V + +Q+ IK +++E + Sbjct 140 VNIVTIRENTEGEYSGIEH-------VIVDGVVQS----------------IKLITEEAS 176 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ A +YA +N R +VT VHK NIM+ ++G F EVA Sbjct 177 KRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA----------------- 219 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 EN K I ++ D ++ P+++ V+ NL GD +SD A +GG+G+ P Sbjct 220 ENCK---DIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSG 276 Query 337 NL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-WKEAADLVVQGIEGAI 394 N+ ++ V +FE+ HGTAP AG+D NP +L+LSA MMLR++G + AA + Sbjct 277 NIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIK 336 Query 395 ESKTVTYDF 403 + K++T D Sbjct 337 DGKSLTKDL 345 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Rickettsia bellii RML369-C] Sequence ID: Q1RJU4.1 Length: 483 Range 1: 12 to 341 Score:174 bits(442), Expect:3e-48, Method:Compositional matrix adjust., Identities:124/385(32%), Positives:189/385(49%), Gaps:57/385(14%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIK 103 GDGIG +I + ++ A + ++E +E+ GEK V + + +++ E+I+ Sbjct 12 GDGIGPEIMEAVLYILRKA-----EARIRLETIEV--GEKLY-VKHYSSGISEQSWESIE 63 Query 104 EYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFR 163 V +K P+TTP GGG +SLNV +R+ L L+ +RP F P +N+ I R Sbjct 64 RTGVILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSF--YPFTKTLHPNLNLTIIR 121 Query 164 ENSEDIYAGIEWPAGSP--EAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVR 221 EN ED+YAGIE+ E+VKLI S+ G +++R Sbjct 122 ENEEDLYAGIEYRQTHNMYESVKLI-------------------------SRTGCEKIIR 156 Query 222 RAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKT 281 A +YA+ N+R VT + K NIMKF++G F E+A KE+ Sbjct 157 YAFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIA-KEY------------------ 197 Query 282 GQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT 341 +I + I D ++ +P + VI T NL GD ISD A G +G+A AN+ + Sbjct 198 -PQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSANIGEH 256 Query 342 VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTY 401 +FEA HG+AP AGQD NP L+ +A MML ++G + A L+ + IE T Sbjct 257 YAMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGMHTA 316 Query 402 DFARLMTGAKEVSTSQFGKAIIKHI 426 D K+V T +F + ++K + Sbjct 317 DIYNKDHSTKKVGTKEFAEEVVKRL 341 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [Kluyveromyces lactis NRRL Y-1140] Sequence ID: O94230.1 Length: 368 Range 1: 38 to 368 Score:171 bits(433), Expect:4e-48, Method:Compositional matrix adjust., Identities:126/393(32%), Positives:191/393(48%), Gaps:67/393(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + FIEGDG+G +I+ +K + AA K IEW + + +PD Sbjct 38 VSFIEGDGVGPEISKSVKAIFSAA-------KVPIEWESC---DVSPIFVNGLTTIPDPA 87 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 + +I + +A+KGPL TP+G G RSLN+ LR+ L+ +RP + G + T E VN Sbjct 88 VASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKT---TYENVN 144 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 +V+ REN+E Y+GIE +P V+ IK ++++ + R Sbjct 145 LVLIRENTEGEYSGIEHVV-APGVVQ----------------------SIKLITQDASER 181 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 ++R A +YA DR V +VHK I + +G F D AK L E Sbjct 182 VIRYAFEYARAVDRSKVLVVHKSTIQRLADGLFVDV----------AKKLSS------EY 225 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYS--VIATLNLNGDYISDALAA-EVGGIGIAPG 335 P I ++ + D + + + P Y V+ NL GD +SD + G +G+ P Sbjct 226 PD----IELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDILSDLNSGLSAGSLGLTPS 281 Query 336 ANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIE 395 AN+ TV +FEA HG+AP AGQ+K NP +L+LS+ MML ++G E AD + + + I Sbjct 282 ANIGHTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADKIEKAVLTTIA 341 Query 396 SKTVTYDFARLMTG--AKEVSTSQFGKAIIKHI 426 S A+ TG STS F A+I+ + Sbjct 342 SD------AKNRTGDLGGSASTSSFTDAVIERL 368 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Pongo abelii] Sequence ID: Q5R678.1 Length: 366 Range 1: 34 to 345 Score:170 bits(430), Expect:1e-47, Method:Compositional matrix adjust., Identities:118/369(32%), Positives:182/369(49%), Gaps:61/369(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKD-NWL-PD 96 + I GDGIG +I+ + + DAA K I+W E T + G W+ P Sbjct 34 VTLIPGDGIGPEISAAVMKIFDAA-------KAPIQWEE----RNVTAIQGPGGKWMIPS 82 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 E E++ + ++ +KGPL TP+ G S+N+ LR+ DLY +RP G +P Sbjct 83 EAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---D 139 Query 157 VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 VN+V REN+E Y+GIE V + +Q+ IK +++ + Sbjct 140 VNIVTIRENTEGEYSGIEH-------VIVDGVVQS----------------IKLITEGAS 176 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ A +YA +N R +VT VHK NIM+ ++G F EVA Sbjct 177 KRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA----------------- 219 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 EN K I ++ D ++ P+++ V+ NL GD +SD A +GG+G+ P Sbjct 220 ENCK---DIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSG 276 Query 337 NL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-WKEAADLVVQGIEGAI 394 N+ ++ V +FE+ HGTAP AG+D NP +L+LSA MMLR++G + AA + Sbjct 277 NIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIK 336 Query 395 ESKTVTYDF 403 + K++T D Sbjct 337 DGKSLTKDL 345 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Homo sapiens] Sequence ID: P50213.1 Length: 366 Range 1: 34 to 345 Score:170 bits(430), Expect:1e-47, Method:Compositional matrix adjust., Identities:115/369(31%), Positives:182/369(49%), Gaps:61/369(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKD-NWL-PD 96 + I GDGIG +I+ + + DAA K I+W E T + G W+ P Sbjct 34 VTLIPGDGIGPEISAAVMKIFDAA-------KAPIQWEE----RNVTAIQGPGGKWMIPS 82 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 E E++ + ++ +KGPL TP+ G S+N+ LR+ DLY +RP G +P Sbjct 83 EAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---D 139 Query 157 VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 VN+V REN+E Y+GIE V + +Q+ IK +++ + Sbjct 140 VNIVTIRENTEGEYSGIEH-------VIVDGVVQS----------------IKLITEGAS 176 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ A +YA +N R +VT VHK NIM+ ++G F EVA Sbjct 177 KRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA----------------- 219 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 ++ + I ++ D ++ P+++ V+ NL GD +SD A +GG+G+ P Sbjct 220 ---ESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSG 276 Query 337 NL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-WKEAADLVVQGIEGAI 394 N+ ++ V +FE+ HGTAP AG+D NP +L+LSA MMLR++G + AA + Sbjct 277 NIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIK 336 Query 395 ESKTVTYDF 403 + K++T D Sbjct 337 DGKSLTKDL 345 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Sus scrofa] Sequence ID: P56471.2 Length: 366 Range 1: 34 to 345 Score:169 bits(429), Expect:1e-47, Method:Compositional matrix adjust., Identities:118/369(32%), Positives:182/369(49%), Gaps:61/369(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKD-NWL-PD 96 + I GDGIG +I+ + + DAA K I+W E T + G W+ P Sbjct 34 VTLIPGDGIGPEISAAVMKIFDAA-------KAPIQWEE----RNVTAIQGPGGKWMIPP 82 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 E E++ + ++ +KGPL TP+ G S+N+ LR+ DLY +RP G +P Sbjct 83 EAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---D 139 Query 157 VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 VN+V REN+E Y+GIE V + +Q+ IK +++ + Sbjct 140 VNIVTIRENTEGEYSGIEH-------VIVDGVVQS----------------IKLITEGAS 176 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ A +YA +N R +VT VHK NIM+ ++G F EVA Sbjct 177 KRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA----------------- 219 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 EN K I ++ D ++ P+++ V+ NL GD +SD A +GG+G+ P Sbjct 220 ENCK---DIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSG 276 Query 337 NL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-WKEAADLVVQGIEGAI 394 N+ ++ V +FE+ HGTAP AG+D NP +L+LSA MMLR++G + AA + Sbjct 277 NIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIETACFATIK 336 Query 395 ESKTVTYDF 403 + K++T D Sbjct 337 DGKSLTKDL 345 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitrate dehydrogenase subunits 3/4; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Bos taurus] Sequence ID: P41563.1 Length: 366 Range 1: 34 to 345 Score:169 bits(428), Expect:2e-47, Method:Compositional matrix adjust., Identities:117/367(32%), Positives:181/367(49%), Gaps:57/367(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG +I+ + + DAA K I+W E A + G +P E Sbjct 34 VTLIPGDGIGPEISAAVMKIFDAA-------KAPIQWEERNVA--AIQGPGGKWMIPPEA 84 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 E++ + ++ +KGPL TP+ G S+N+ LR+ DLY +RP G +P VN Sbjct 85 KESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPY---HDVN 141 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 +V REN+E Y+GIE V + +Q+ IK +++ + R Sbjct 142 IVTIRENTEGEYSGIEH-------VIVDGVVQS----------------IKLITEAASKR 178 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 + A +YA +N R +VT VHK NIM+ ++G F EVA EN Sbjct 179 IAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA-----------------EN 221 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 K I ++ D ++ P+++ V+ NL GD +SD A +GG+G+ P N+ Sbjct 222 CK---DIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNI 278 Query 339 -SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-WKEAADLVVQGIEGAIES 396 ++ V +FE+ HGTAP AG+D NP +L+LSA MMLR++G + AA + + Sbjct 279 GANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIETACFATIKDG 338 Query 397 KTVTYDF 403 K++T D Sbjct 339 KSLTKDL 345 >RecName: Full=Isocitrate/homoisocitrate dehydrogenase; AltName: Full=Homoisocitrate dehydrogenase; Short=HICDH [Thermus thermophilus HB8] Sequence ID: Q5SIJ1.1 Length: 334 >RecName: Full=Isocitrate/homoisocitrate dehydrogenase; AltName: Full=Homoisocitrate dehydrogenase; Short=HICDH [Thermus thermophilus HB27] Sequence ID: Q72IW9.1 Length: 334 Range 1: 5 to 331 Score:168 bits(425), Expect:3e-47, Method:Compositional matrix adjust., Identities:127/394(32%), Positives:192/394(48%), Gaps:73/394(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I IEGDGIG ++ P + V++A +E++E AG + + G +P+ET Sbjct 5 ICLIEGDGIGHEVIPAARRVLEAT-------GLPLEFVEAEAGWETFERRG--TSVPEET 55 Query 99 LEAIKEYQVAIKGPLTTPVG------GGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 +E I + G T+P G IR L R++LDLY +RP + P P Sbjct 56 VEKILSCHATLFGAATSPTRKVPGFFGAIRYL----RRRLDLYANVRPAK---SRPVPGS 108 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 P V++VI REN+E +Y E R+ + A I +S Sbjct 109 RP-GVDLVIVRENTEGLYVEQER-----------------------RYLDVA-IADAVIS 143 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 K+ + R+ R A++ A R ++ + HK N++ T+G F D EVA K+F PL Sbjct 144 KKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVA-KDF---PL---- 195 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 + ++D+I D Q+++RP + VI T NL GD +SD A VGG+G+ Sbjct 196 ------------VNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGL 243 Query 333 APGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEG 392 AP N+ DT +FE HG+AP AG+ NP + ILSA MML YLG KEAA V + ++ Sbjct 244 APSGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDL 303 Query 393 AIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +E T D + +T F +A+++ + Sbjct 304 VLERGPRTPDL------GGDATTEAFTEAVVEAL 331 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [Schizosaccharomyces pombe 972h-] Sequence ID: Q9USP8.2 Length: 379 Range 1: 49 to 378 Score:169 bits(428), Expect:3e-47, Method:Compositional matrix adjust., Identities:121/396(31%), Positives:190/396(47%), Gaps:74/396(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVY----GKDNWL 94 + I GDGIG +IA ++ + AA K IEW + KVY + Sbjct 49 VTMIAGDGIGPEIAQSVERIFKAA-------KVPIEWERV-------KVYPILKNGTTTI 94 Query 95 PDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 PD+ E++++ +VA+KGPL TP+G G S+N+ LR+ L+ +RP TG +P Sbjct 95 PDDAKESVRKNKVALKGPLATPIGKGHVSMNLTLRRTFGLFANVRPCVSITGYKTPY--- 151 Query 155 EKVNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 + VN V+ REN+E Y+GIE G +++KLI + Sbjct 152 DNVNTVLIRENTEGEYSGIEHEVIPGVVQSIKLI-------------------------T 186 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 + + R++R A QYA ++++T+VHK IM+ +G F + E+A Sbjct 187 RAASERVIRYAFQYARQTGKNNITVVHKATIMRMADGLFLECAKELAP------------ 234 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEY--SVIATLNLNGDYISDALAAEVGGI 330 E P I +++ I D +I+ P Y +V+ NL GD +SD A +GG+ Sbjct 235 ----EYP----DIELREEILDNACLKIVTDPVPYNNTVMVMPNLYGDIVSDMCAGLIGGL 286 Query 331 GIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGI 390 G+ P N+ + +FEA HGTAP AG+ NP +L+LS+ MML+++ + A + I Sbjct 287 GLTPSGNIGNQASIFEAVHGTAPDIAGKGLANPTALLLSSVMMLKHMNLNDYA----KRI 342 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 E AI AR + + Q+ AII + Sbjct 343 ESAIFDTLANNPDARTKDLGGKSNNVQYTDAIISKL 378 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [Saccharomyces cerevisiae S288C] Sequence ID: P28241.1 Length: 369 Range 1: 39 to 369 Score:168 bits(425), Expect:6e-47, Method:Compositional matrix adjust., Identities:121/393(31%), Positives:191/393(48%), Gaps:67/393(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + FIEGDGIG +I+ +K + AA IEW + + +PD Sbjct 39 VSFIEGDGIGPEISKSVKKIFSAA-------NVPIEWESC---DVSPIFVNGLTTIPDPA 88 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 +++I + VA+KGPL TP+G G RSLN+ LR+ L+ +RP + G + T E V+ Sbjct 89 VQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKT---TYENVD 145 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 +V+ REN+E Y+GIE P V+ IK ++++ + R Sbjct 146 LVLIRENTEGEYSGIEHIV-CPGVVQ----------------------SIKLITRDASER 182 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 ++R A +YA R V +VHK I + +G F + E++ KE+ Sbjct 183 VIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELS-KEY--------------- 226 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYS--VIATLNLNGDYISDALAA-EVGGIGIAPG 335 +T++ + D + +++ P+ Y+ V NL GD +SD + G +G+ P Sbjct 227 ----PDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPS 282 Query 336 ANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIE 395 AN+ + +FEA HG+AP AGQDK NP +L+LS+ MML ++G AD + + I Sbjct 283 ANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIA 342 Query 396 S--KTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 S + T D A T TS F +A+IK + Sbjct 343 SGPENRTGDLAGTAT------TSSFTEAVIKRL 369 >RecName: Full=Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Caenorhabditis elegans] Sequence ID: Q93714.3 Length: 358 Range 1: 27 to 327 Score:167 bits(423), Expect:8e-47, Method:Compositional matrix adjust., Identities:117/360(33%), Positives:174/360(48%), Gaps:63/360(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDN--WLPD 96 + I GDGIG +I+ ++ + +AA I W + T V G+D +P Sbjct 27 VTLIPGDGIGPEISASVQKIFEAA-------DAPIAWDPV----DVTPVKGRDGVFRIPS 75 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 +E + +V +KGPL TP+G G RSLN+A+R++ LY +RP R G + + Sbjct 76 RCIELMHANKVGLKGPLETPIGKGHRSLNLAVRKEFSLYANVRPCRSLEGHKTLY---DN 132 Query 157 VNMVIFRENSEDIYAGIEWP--AGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 V++V REN+E Y+GIE G +++KLI ETA Sbjct 133 VDVVTIRENTEGEYSGIEHEIVPGVVQSIKLIT--------------ETA---------- 168 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 + + A +YA N R VT VHK NIM+ ++G F E A Sbjct 169 -SRNVASFAFEYARQNGRKVVTAVHKANIMRQSDGLFLSICREQAA-------------- 213 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 ++ + I K+ D ++ P++Y V+ NL GD +SD A VGG+G+ P Sbjct 214 LYPD------IKFKEAYLDTVCLNMVQDPSQYDVLVMPNLYGDILSDLCAGLVGGLGVTP 267 Query 335 GANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAI 394 N+ +FE+ HGTAP AGQDK NP +L+LSA MMLRY+ + A + + + AI Sbjct 268 SGNIGKGAAVFESVHGTAPDIAGQDKANPTALLLSAVMMLRYMNLPQHAARIEKAVFDAI 327 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Rickettsia prowazekii str. Madrid E] Sequence ID: Q9ZDR0.1 Length: 483 Range 1: 12 to 341 Score:169 bits(429), Expect:2e-46, Method:Compositional matrix adjust., Identities:117/383(31%), Positives:182/383(47%), Gaps:53/383(13%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIK 103 GDGIG +I + ++ A + +I I GEK K + + +E+ + I+ Sbjct 12 GDGIGPEIMEAVLYILRKA-------EARISLETIEVGEKLYKKHYTSG-ISEESWDVIQ 63 Query 104 EYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFR 163 + +K P+TTP GG +SLNV +R+ L L+ +RPV F P +N+ I R Sbjct 64 RTGIILKAPITTPQSGGYKSLNVTIRKTLQLFANIRPVVSF--YPFTRTLHPNLNLTIIR 121 Query 164 ENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRA 223 EN ED+Y+G+E+ R +K +S G +++R A Sbjct 122 ENEEDLYSGVEY-----------------------RQTHNMYESMKLISHTGCKKIIRYA 158 Query 224 IQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQ 283 +YAI N+R VT + K NIMKF++G F E+A KE+ Sbjct 159 FEYAIKNNRKKVTCLTKDNIMKFSDGIFHRVFNEIA-KEY-------------------P 198 Query 284 KITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG 343 +I + I D ++ +P + +I T NL GD ISD A G +G+A AN+ Sbjct 199 QINNEHYIIDIGTAKLATKPEIFDIIVTSNLYGDIISDVAAEISGSVGLAGSANIGQHYA 258 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDF 403 +FEA HG+AP AG+ NP L+ +A MML ++G + A L+ + IE T+D Sbjct 259 MFEAVHGSAPDIAGKGIANPSGLLNAAIMMLVHIGQGDIASLIENAWKKTIEDGVHTFDI 318 Query 404 ARLMTGAKEVSTSQFGKAIIKHI 426 + +K+V T +F +IK + Sbjct 319 YNEHSSSKKVCTKEFAVEVIKRL 341 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Rickettsia conorii str. Malish 7] Sequence ID: Q92IR7.1 Length: 483 Range 1: 12 to 341 Score:169 bits(427), Expect:3e-46, Method:Compositional matrix adjust., Identities:119/386(31%), Positives:186/386(48%), Gaps:59/386(15%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIK 103 GDGIG +I + ++ A + ++E +E+ GEK K + + + +E+ E+I+ Sbjct 12 GDGIGPEIMEAVLYILRKA-----EARIRLETIEV--GEKLYKKH-YTSGISEESWESIQ 63 Query 104 EYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRP---VRYFTGVPSPVKTPEKVNMV 160 + +K P+TTP GGG +SLNV +R+ L L+ +RP + FT P +N+ Sbjct 64 RTGIILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPAVSLHPFTRTLHP-----NLNLT 118 Query 161 IFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLV 220 I REN ED+YAGIE+ R +K +S G +++ Sbjct 119 IIRENEEDLYAGIEY-----------------------RQTHNMYESMKLISHTGCEKII 155 Query 221 RRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPK 280 R A +YA+ N+R V + K NIMKF++G E+A KE+ Sbjct 156 RYAFEYAVKNNRKKVMCLSKDNIMKFSDGVLHKVFNEIA-KEY----------------- 197 Query 281 TGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD 340 +I I D ++ +P + VI T NL GD ISD A G +G+A AN+ Sbjct 198 --PQINNAHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSANIGQ 255 Query 341 TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVT 400 +FEA HG+AP AG+D NP L+ +A MML ++G + A L+ + IE T Sbjct 256 HYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGVHT 315 Query 401 YDFARLMTGAKEVSTSQFGKAIIKHI 426 D + +K+V T +F + + K + Sbjct 316 ADIYNEQSSSKKVGTKEFAEEVTKRL 341 >RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; AltName: Full=IDH-I; AltName: Full=Isocitric dehydrogenase 1; AltName: Full=NAD(+)-specific ICDH 1; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q8LFC0.2 Length: 367 Range 1: 40 to 349 Score:166 bits(420), Expect:3e-46, Method:Compositional matrix adjust., Identities:119/374(32%), Positives:184/374(49%), Gaps:73/374(19%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG P++ N V+ +E +A + E Y V+G+ + +P E Sbjct 40 VTLIPGDGIG----PLVTNAVEQVMEAMHAPI----FFEKY------DVHGEMSRVPPEV 85 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 +E+I++ +V +KG L TPVGGG+ SLNV LR++LDL+ L G+P+ E V+ Sbjct 86 MESIRKNKVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPT---RHENVD 142 Query 159 MVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 +V+ REN+E YAG+E G E++K+I +K + Sbjct 143 IVVIRENTEGEYAGLEHEVVPGVVESLKVI-------------------------TKFCS 177 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ + A +YA N+R VT VHK NIMK +G F + EVA Sbjct 178 ERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVA----------------- 220 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 K IT ++I D Q++ +P ++ V+ T NL G+ +++ A GG G+ PG Sbjct 221 ---KKYPSITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGG 277 Query 337 NLSDTVGLFEATHGTAPKYAGQDKV------NPGSLILSAEMMLRYLGWKEAADLVVQGI 390 N+ +FE G + G+DK+ NP +L+LS+ MMLR+L + AD + + Sbjct 278 NVGADHAVFE--QGASAGNVGKDKIVLENKANPVALLLSSAMMLRHLQFPSFADRLETAV 335 Query 391 EGAI-ESKTVTYDF 403 + I E K T D Sbjct 336 KKVIAEGKCRTKDL 349 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit alpha; AltName: Full=NAD(+)-specific ICDH subunit alpha; Flags: Precursor [Rattus norvegicus] Sequence ID: Q99NA5.1 Length: 366 Range 1: 34 to 345 Score:166 bits(419), Expect:4e-46, Method:Compositional matrix adjust., Identities:120/372(32%), Positives:180/372(48%), Gaps:67/372(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKD-NWL-PD 96 + I GDGIG +I+ + + DAA K I+W E T + G W+ P Sbjct 34 VTLIPGDGIGPEISASVMKIFDAA-------KAPIQWEE----RNVTAIQGPGGKWMIPP 82 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 E E++ + ++ +KGPL TP+ G S+N+ LR+ DLY +RP G +P Sbjct 83 EAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---D 139 Query 157 VNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 VN+V REN+E Y+GIE G +++KLI E Sbjct 140 VNIVTIRENTEGEYSGIEHVIVDGVVQSIKLIT--------------------------E 173 Query 215 GTS-RLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW 273 G S R+ A +YA +N R +VT VHK NIM+ ++G F EVA Sbjct 174 GASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVA-------------- 219 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 EN K I ++ D ++ P+++ V+ NL GD +SD A +GG+G+ Sbjct 220 ---ENCK---DIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVT 273 Query 334 PGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-WKEAADLVVQGIE 391 N+ ++ V +FE+ HGTAP AG+D NP +L+LSA MMLR++G + AA + Sbjct 274 QSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFA 333 Query 392 GAIESKTVTYDF 403 + K++T D Sbjct 334 TIKDGKSLTKDL 345 >RecName: Full=3-isopropylmalate dehydrogenase, chloroplastic; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase; Flags: Precursor [Solanum tuberosum] Sequence ID: P29696.1 Length: 357 Range 1: 44 to 336 Score:165 bits(418), Expect:5e-46, Method:Compositional matrix adjust., Identities:112/351(32%), Positives:177/351(50%), Gaps:62/351(17%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDN-WLPDETLEAI 102 GDGIG +IA ++ + A + IEW E Y G T+V + N +L E+LE++ Sbjct 44 GDGIGPEIAESVRQIFKVA-------EVPIEWEEHYVG---TEVDPRTNSFLTWESLESV 93 Query 103 KEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIF 162 + +V +KGP+ TP+G G RSLN+ LR++L+LY +RP G + + VN++ Sbjct 94 RRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRY---DDVNLITI 150 Query 163 RENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLV 220 REN+E Y+G+E G E++K+I +++ + R+ Sbjct 151 RENTEGEYSGLEHQVVRGVVESLKII-------------------------TRQASLRVA 185 Query 221 RRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPK 280 A YA + R+ V+ +HK NIM+ T+G F EVA K Sbjct 186 EYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKY------------------ 227 Query 281 TGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD 340 +I ++V+ D ++ PA + V+ NL GD ISD A +GG+G+ P N+ + Sbjct 228 --PEIKYEEVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGE 285 Query 341 -TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGI 390 + L EA HG+AP AG++ NP +L+LS+ MLR+L + AD + I Sbjct 286 GGIALAEAVHGSAPDIAGKNLANPTALLLSSVSMLRHLELHDKADRIQDAI 336 >RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase [Rickettsia typhi str. Wilmington] Sequence ID: Q68XA5.1 Length: 483 Range 1: 12 to 341 Score:168 bits(426), Expect:5e-46, Method:Compositional matrix adjust., Identities:117/383(31%), Positives:180/383(46%), Gaps:53/383(13%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIK 103 GDGIG +I +DA + + +I I GEK K + + +E+ I+ Sbjct 12 GDGIGPEI-------MDAVLYILRQAEARISLETIEVGEKLYKKHYTSG-ISEESWNVIQ 63 Query 104 EYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFR 163 + +K P+TTP GG +SLNV +R+ L L+ +RP F P +N+ I R Sbjct 64 RTGIILKAPITTPQSGGYKSLNVTIRKTLQLFANIRPAVSFH--PFTRTLHPNLNLTIIR 121 Query 164 ENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRA 223 EN ED+Y+GIE+ R +K +S G +++R A Sbjct 122 ENEEDLYSGIEY-----------------------RQTHNMYESLKLISHTGCKKIIRYA 158 Query 224 IQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQ 283 +YA+ N+R VT + K NIMKF++G F E+A KE+ Sbjct 159 FEYAVKNNRKKVTCLSKDNIMKFSDGIFHRVFNEIA-KEY-------------------P 198 Query 284 KITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTVG 343 +I + I D ++ P + +I T NL GD ISD A G +G+A AN+ Sbjct 199 QIDNEHYIIDIGTAKLATTPEIFDIIVTSNLYGDIISDVAAEISGSVGLAGSANIGQHYA 258 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKTVTYDF 403 +FEA HG+AP AG+ NP L+ +A MML ++G + A L+ + IE T+D Sbjct 259 MFEAVHGSAPDIAGKGIANPSGLLNAAIMMLVHIGQGDIASLIENAWKKTIEDGVHTFDI 318 Query 404 ARLMTGAKEVSTSQFGKAIIKHI 426 + +K+V T +F + +IK + Sbjct 319 YSEHSSSKKVCTKEFAEEVIKRL 341 >RecName: Full=Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial; AltName: Full=IDH-VI; AltName: Full=Isocitric dehydrogenase 6; AltName: Full=NAD(+)-specific ICDH 6; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q8LG77.2 Length: 374 Range 1: 28 to 374 Score:164 bits(416), Expect:2e-45, Method:Compositional matrix adjust., Identities:127/411(31%), Positives:194/411(47%), Gaps:69/411(16%) Query 21 GEKITVNKAVLEVPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYA 80 G I+V++A GDGIG +IA +K V AA I+W E + Sbjct 28 GPFISVSRAFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAA-------DVVIDWDEQFV 80 Query 81 GEKATKVYGKDN-WLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLR 139 G T+V + N +L + L+++ + +V +KGP+ TP+G G RSLN+ LR++L+LY +R Sbjct 81 G---TEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVR 137 Query 140 PVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKK 197 P G + + V+++ REN+E Y+G+E G E++K+I Sbjct 138 PCYSLPGYKTRY---DDVDLITIRENTEGEYSGLEHQVVKGVVESLKII----------- 183 Query 198 IRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYE 257 +++ + R+ A YA + R V+ +HK NIM+ T+G F E Sbjct 184 --------------TRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDE 229 Query 258 VAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGD 317 VA K +I + V+ D ++ PA + V+ NL GD Sbjct 230 VAAKY--------------------PEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGD 269 Query 318 YISDALAAEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 ISD A VGG+G+ P N+ D + L EA HG+AP AG + NP +L+LS MMLR+ Sbjct 270 IISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRH 329 Query 377 LGWKEAADLVVQGIEGAI-ESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 L + A+ + I I E K T D +T+ F KAI H+ Sbjct 330 LKLNKQAEQIHSAIINTIAEGKYRTADL------GGSSTTTDFTKAICDHL 374 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Methanothermobacter thermautotrophicus str. Delta H] Sequence ID: O27441.1 Length: 329 Range 1: 6 to 327 Score:160 bits(406), Expect:1e-44, Method:Compositional matrix adjust., Identities:118/388(30%), Positives:187/388(48%), Gaps:66/388(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I I GDGIG++ V++AA+ +E++ AG+ K G LP+ET Sbjct 6 IAVIPGDGIGVE-------VMEAALHILNTLDLDLEFIHADAGDACLKRTG--TALPEET 56 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 LEA+ E + + G G + V LR++ DL+ LRPV+ GVP P+ ++ Sbjct 57 LEAVGEARATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLY--PD-LD 109 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 VI REN+ED+Y G E +PE + + +++ + R Sbjct 110 FVIVRENTEDLYVGDEEY--TPEG----------------------AVAKRIITRTASRR 145 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 + + A QYA VT VHK N++K T+G F+D Y+VA E Sbjct 146 ISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVAS----------------EY 189 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 P+ + D DA ++ +P E+ I T NL GD +SD A +GG+G+AP AN+ Sbjct 190 PQ----MEATDYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGLIGGLGLAPSANI 245 Query 339 SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKT 398 + LFE HG+AP+ AG++ NP ++IL+ +ML++L K+ A + + ++ + Sbjct 246 GEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKHLNKKQEAQKIEKALQKTLAEGL 305 Query 399 VTYDFARLMTGAKEVSTSQFGKAIIKHI 426 VT D G K + T + I +H+ Sbjct 306 VTPDL-----GGK-LGTMEMAAEIARHL 327 >RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial; AltName: Full=IDH-II; AltName: Full=Isocitric dehydrogenase 2; AltName: Full=NAD(+)-specific ICDH 2; Flags: Precursor [Arabidopsis thaliana] Sequence ID: P93032.2 Length: 367 Range 1: 38 to 349 Score:159 bits(401), Expect:2e-43, Method:Compositional matrix adjust., Identities:120/377(32%), Positives:180/377(47%), Gaps:74/377(19%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLP 95 RP+ I GDG+G P++ N V +E +A + E + +V+G LP Sbjct 38 RPVT-LIPGDGVG----PLVTNAVQQVMEAMHAPV----YFEPF------EVHGDMKSLP 82 Query 96 DETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 + LE+IK+ +V +KG L TPVGGG+ SLNV LR++LDL+ L V F +P E Sbjct 83 EGLLESIKKNKVCLKGGLKTPVGGGVSSLNVNLRKELDLFASL--VNCFN-LPGLASRHE 139 Query 156 KVNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSK 213 V++V+ REN+E YAG+E G E++K+I +K Sbjct 140 NVDIVVIRENTEGEYAGLEHEVVPGVVESLKVI-------------------------TK 174 Query 214 EGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW 273 + R+ + A +YA N+R VT VHK NIMK +G F + EVA Sbjct 175 FCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCQEVA-------------- 220 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 K I ++I D Q++ RP ++ V+ T NL G+ +++ A GG G+ Sbjct 221 ------KKYPSIAYNEIIVDNCCMQLVARPEQFDVMVTPNLYGNLVANTAAGIAGGTGVM 274 Query 334 PGANLSDTVGLFEATHGTAPKYAGQD------KVNPGSLILSAEMMLRYLGWKEAADLVV 387 PG N+ +FE G + G+D NP +L+LS+ MMLR+L + AD + Sbjct 275 PGGNVGAEYAVFE--QGASAGNVGKDTTEEQKNANPVALLLSSAMMLRHLQFPSFADRLE 332 Query 388 QGIEGAI-ESKTVTYDF 403 ++ I E T D Sbjct 333 TAVKRVIAEGNCRTEDL 349 >RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial; AltName: Full=IDH-III; AltName: Full=Isocitric dehydrogenase 3; AltName: Full=NAD(+)-specific ICDH 3; Flags: Precursor [Arabidopsis thaliana] Sequence ID: O81796.1 Length: 368 Range 1: 41 to 350 Score:159 bits(401), Expect:2e-43, Method:Compositional matrix adjust., Identities:119/372(32%), Positives:178/372(47%), Gaps:69/372(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG P++ V+ +E +A E Y +V G +P+E Sbjct 41 VTLIPGDGIG----PLVTGAVEQVMEAMHAPVH----FERY------EVLGNMRKVPEEV 86 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 +E++K +V +KG L TPVGGG+ SLN+ LR++LD++ L VP V E V+ Sbjct 87 IESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNC---INVPGLVTRHENVD 143 Query 159 MVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 +V+ REN+E Y+G+E G E++K+I +K + Sbjct 144 IVVIRENTEGEYSGLEHEVVPGVVESLKVI-------------------------TKFCS 178 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ R A +YA N+R VT VHK NIMK +G F + EVA Sbjct 179 ERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVA----------------- 221 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 K IT ++I D Q++ +P ++ V+ T NL G+ I++ A GG G+ PG Sbjct 222 ---KHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGG 278 Query 337 NLSDTVGLFE--ATHGTA--PKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEG 392 N+ +FE A+ G K Q K NP +L+LS+ MMLR+L + AD + ++ Sbjct 279 NVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQ 338 Query 393 AI-ESKTVTYDF 403 I E K T D Sbjct 339 VIKEGKYRTKDL 350 >RecName: Full=Isocitrate dehydrogenase [NAD] regulatory subunit B, mitochondrial; Flags: Precursor [Dictyostelium discoideum] Sequence ID: Q54B68.1 Length: 360 Range 1: 29 to 355 Score:158 bits(400), Expect:2e-43, Method:Compositional matrix adjust., Identities:128/394(32%), Positives:188/394(47%), Gaps:70/394(17%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEW--MEIYAGEKATKVYGKDNW 93 + + I GDGIG +I + V AA K IEW +I G+ Sbjct 29 KKTVTVIPGDGIGPEITSSVMGVFQAA-------KVPIEWEIFDISGGQP---------- 71 Query 94 LPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKT 153 + E + +I +VA+KGPL T + G +S N+ LR+ LDLY + P + G+ + Sbjct 72 ISQELIASITRNKVALKGPLYTEILSGSQSRNMELRKALDLYAHVVPCKQIPGITAR-HD 130 Query 154 PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSK 213 V+ V+ REN++ Y+G+E +P V+ +K ++K Sbjct 131 DVLVDFVVIRENTQGEYSGLEQVL-TPGVVQ----------------------SLKIITK 167 Query 214 EGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW 273 E + R+ R A +YA N R VT VHK NI K T+G F ++A KE+ P Sbjct 168 EASERIARYAFEYAKANGRKKVTAVHKANIQKQTDGLFLATCTQIA-KEY--------PE 218 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 FEN I D Q++ P +Y V+ T NL G+ +S+ AA VGG G+A Sbjct 219 IKFEN-----------TIIDNCCMQLVKSPEQYDVMVTPNLYGNIVSNIGAALVGGPGLA 267 Query 334 PGANLSDTVGLFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEG 392 GAN+ + +FE H A AG+DK NP L+L++ MML++LG E A V ++ Sbjct 268 GGANVGEGSIIFEMGAHHVAADIAGKDKANPTGLLLASVMMLKHLGLNEHATKVENAVKA 327 Query 393 AIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 I+ T+T D G K ST QF A+I +I Sbjct 328 VIKEGTLTSDI-----GGKS-STKQFTGAVIDYI 355 >RecName: Full=3-isopropylmalate/3-methylmalate dehydrogenase; AltName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; Short=IPMDH; AltName: Full=Beta-IPM dehydrogenase; AltName: Full=D-malate dehydrogenase [decarboxylating] [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q58130.2 Length: 333 Range 1: 4 to 301 Score:157 bits(397), Expect:3e-43, Method:Compositional matrix adjust., Identities:122/354(34%), Positives:170/354(48%), Gaps:57/354(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I IEGDGIG ++ P V++A E++ AG++ K GK LP+ET Sbjct 4 ICVIEGDGIGKEVVPATIQVLEAT-------GLPFEFVYAEAGDEVYKRTGK--ALPEET 54 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 +E + + G G + V LR LD Y +RPV+ + GV P+ ++ Sbjct 55 IETALDCDAVLFGA----AGETAADVIVKLRHILDTYANIRPVKAYKGVKCL--RPD-ID 107 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKI-RFPETAGIGIKPVSKEGTS 217 VI REN+E +Y GIE A E + + + E ++I RF K + KEG Sbjct 108 YVIVRENTEGLYKGIE--AEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEG-- 163 Query 218 RLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFE 277 VT HK N++K T+G FK Y+VA +E+ Sbjct 164 ----------------KVTCAHKANVLKLTDGLFKKIFYKVA-EEY-------------- 192 Query 278 NPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGAN 337 I +D DA I+ +P + V+ T NL GD +SD A VGG+G+AP AN Sbjct 193 -----DDIKAEDYYIDAMNMYIITKPQVFDVVVTSNLFGDILSDGAAGTVGGLGLAPSAN 247 Query 338 LSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 + D GLFE HG+AP AG+ NP + ILSA +MLRYLG EAAD V + +E Sbjct 248 IGDEHGLFEPVHGSAPDIAGKKIANPTATILSAVLMLRYLGEYEAADKVEKALE 301 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [Histoplasma capsulatum] Sequence ID: O13302.1 Length: 388 Range 1: 54 to 381 Score:153 bits(386), Expect:4e-41, Method:Compositional matrix adjust., Identities:117/391(30%), Positives:189/391(48%), Gaps:69/391(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEI-YAGEKATKVYGKDNWLPDE 97 + I GDGIG ++A +K + A IEW ++ +G A + +D L E Sbjct 54 VTLIPGDGIGTEVAESVKTIFKA-------DNVPIEWEQVDVSGLDAGNKHSED--LFKE 104 Query 98 TLEAIKEYQVAIKGPLTTPV-GGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 ++ ++K ++ +KG L TPV G +S NVALRQ+LD+Y + ++ +P + Sbjct 105 SIASLKRNKLGLKGILHTPVERSGHQSFNVALRQELDIYASIVLIK---NIPGYKTRHDN 161 Query 157 VNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 V++ I REN+E Y+G+E + G E++K+I ++E Sbjct 162 VDLCIIRENTEGEYSGLEHQSVSGVVESLKIITRAKSE---------------------- 199 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 R+ + A +A+ N+R VT +HK NIMK +G F+ ++VA Sbjct 200 ---RIAKFAFSFALANNRKKVTCIHKANIMKLADGLFRSTFHKVA--------------- 241 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 ++ + D+I D Q + RP ++ V+ NL G +S+ AA VGG GI P Sbjct 242 -----ESYPTLETNDMIVDNASMQAVARPQQFDVMVMPNLYGGILSNVGAALVGGPGIVP 296 Query 335 GANLSDTVGLFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGA 393 G N+ V +FE G+D+ NP +LILS M+LR+LG E A+ + + + Sbjct 297 GCNMGRDVAVFEPGCRHVGLDIKGKDQANPTALILSGSMLLRHLGLDEHANRISKAVYDV 356 Query 394 I-ESKTVTYDFARLMTGAKEVSTSQFGKAII 423 I E T T D M G + ST +F +A++ Sbjct 357 IGEGVTRTRD----MGG--QASTHEFTRAVL 381 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Archaeoglobus fulgidus DSM 4304] Sequence ID: O29627.1 Length: 326 Range 1: 4 to 323 Score:149 bits(377), Expect:2e-40, Method:Compositional matrix adjust., Identities:118/381(31%), Positives:177/381(46%), Gaps:65/381(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I I GDGIG K V++AA+ E+ AG++A + YGK LPDET Sbjct 4 IVVIPGDGIG-------KEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGK--ALPDET 54 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 LEA ++ + G G + V LR++L + +RP + G+ ++ Sbjct 55 LEACRKSDAVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPG---LD 107 Query 159 MVIFRENSEDIYAGIEWPAGS-PEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTS 217 +V+ REN+E +Y G E+ G EA+++I ++E + Sbjct 108 IVVVRENTECLYMGFEFGFGDVTEAIRVI-------------------------TREASE 142 Query 218 RLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFE 277 R+ R A + A R VT +HK N+MK T G F+D EVA Sbjct 143 RIARYAFELAKREGRKKVTALHKANVMKKTCGLFRDVCREVA------------------ 184 Query 278 NPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGAN 337 K +I D DA +++ P + VI T N+ GD +SD A VGG+G+AP AN Sbjct 185 --KDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGLVGGLGLAPSAN 242 Query 338 LSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESK 397 + + +FE HG A AG+ NP ++IL+A MMLR+ G+ E A V + +E I+ Sbjct 243 VGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRHFGYVEEAKKVEEAVEKTIKEG 302 Query 398 TVTYDFA---RLMTGAKEVST 415 T D + M A EV++ Sbjct 303 KKTPDLGGNLKTMEFANEVAS 323 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [Schizosaccharomyces pombe 972h-] Sequence ID: O13696.1 Length: 356 Range 1: 23 to 353 Score:145 bits(367), Expect:9e-39, Method:Compositional matrix adjust., Identities:122/395(31%), Positives:178/395(45%), Gaps:71/395(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEI--YAGEKATKVYGKDNWLPD 96 + I GDGIG + +A E IE+ EI EK K G Sbjct 23 VTLIPGDGIG-------RETSNAVTEIFKTANVPIEFEEIDVTGMEKNNKSSGD---ALH 72 Query 97 ETLEAIKEYQVAIKGPLTTPV-GGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 E ++++K +V +KG L TP GG S NVALR++LD+Y L ++ +P + Sbjct 73 EAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIK---NIPGFKTRHD 129 Query 156 KVNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSK 213 V+ I REN+E Y+G+E + G E++K+I ++ Sbjct 130 NVDFAIIRENTEGEYSGLEHQSVPGVVESLKII-------------------------TE 164 Query 214 EGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW 273 + R+ + A +A+ N R SVT +HK NIMK +G F+ Y+VA Sbjct 165 YKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVA-------------- 210 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 IT KD+I D Q + RP ++ V+ NL G +S+ +A VGG G+ Sbjct 211 ------NGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSALVGGPGVI 264 Query 334 PGANLSDTVGLFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEG 392 PGAN LFE G+ + NP + ILSA +MLR+LG K+ ADL+ Sbjct 265 PGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYADLINAATYS 324 Query 393 AIES-KTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 IE KT+T D ST F AI++ + Sbjct 325 VIEEGKTLTKDL------GGSASTGDFTHAILERM 353 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [Kluyveromyces lactis NRRL Y-1140] Sequence ID: O94229.1 Length: 361 Range 1: 29 to 358 Score:142 bits(358), Expect:3e-37, Method:Compositional matrix adjust., Identities:114/398(29%), Positives:181/398(45%), Gaps:75/398(18%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEW--MEIYAGEKATKVYGKDNW 93 R + I GDG+G K V D+ V+ I+W ++I E V Sbjct 29 RYTVTLIPGDGVG-------KEVTDSVVKIFENENIPIDWETIDISGLENTENV------ 75 Query 94 LPDETLEAIKEYQVAIKGPLTTPVG-GGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 +E++K +V +KG TP G SLNVALR+QLD++ V F +P Sbjct 76 --QRAVESLKRNKVGLKGIWHTPADQTGHGSLNVALRKQLDIFAN---VALFKSIPGVKT 130 Query 153 TPEKVNMVIFRENSEDIYAGIEWPA--GSPEAVKLINFLQNEMGVKKIRFPETAGIGIKP 210 ++MVI REN+E Y+G+E + G E++K++ ++E Sbjct 131 RLNNIDMVIIRENTEGEYSGLEHESVPGVVESLKIMTRAKSE------------------ 172 Query 211 VSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDG 270 R+ R A +A+ N+R SV VHK NIMK +G F++ E+ E+ Sbjct 173 -------RIARFAFDFALKNNRKSVCAVHKANIMKLGDGLFRNTVNEIGANEY------- 218 Query 271 GPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGI 330 ++ +K++I D Q + +P ++ V+ T NL G + + +A +GG Sbjct 219 ------------PELDVKNIIVDNASMQAVAKPHQFDVLVTPNLYGSILGNIGSALIGGP 266 Query 331 GIAPGANLSDTVGLFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQG 389 G+ PGAN +FE + GQ+ NP ++ILS+ +MLR+LG AD + + Sbjct 267 GLVPGANFGREYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLRHLGLNAYADRISKA 326 Query 390 IEGAI-ESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 I E K+ T D STS+F A+I+ + Sbjct 327 TYDVISEGKSTTRDI------GGSASTSEFTNAVIEKL 358 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Saccharolobus solfataricus P2] Sequence ID: Q9UXB2.1 Length: 336 Range 1: 5 to 282 Score:141 bits(355), Expect:4e-37, Method:Compositional matrix adjust., Identities:106/336(32%), Positives:159/336(47%), Gaps:58/336(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ K ++ +EK I+ +E+ AG+ A YG+ LP T Sbjct 5 VAVIPGDGIGPELYEGSKRIIAKLIEKY---NLDIDLIEVEAGDVALNKYGE--ALPRHT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 L+ I++ + +KGP VG + V LRQ D+Y +RP + V S K P V+ Sbjct 60 LDVIEKADMILKGP----VGETAMDVVVKLRQMYDMYANIRPAKSLPNVQS--KYP-NVD 112 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 +VI REN+ED+Y G E+ + GV I IK ++ + R Sbjct 113 LVIVRENTEDLYKGFEFVTST--------------GVT---------IAIKVTTEFASKR 149 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 +V A+ YA+ R VT VHK N+M+ T+G F E+ L G Sbjct 150 IVNVALNYALMR-RRKVTCVHKANVMRVTDGLFASVCREI---------LKG-------- 191 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 K+ +++ DA ++ P + VI T N+ GD +SD + G +G+AP AN+ Sbjct 192 -----KVNFEEMYVDAAAANLVRDPTRFDVIVTSNVYGDILSDEASQIAGSLGLAPSANI 246 Query 339 SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374 D +FE HG A AG+ NP + +LS MML Sbjct 247 GDRKSMFEPVHGAAFDIAGKGIANPTAFLLSVSMML 282 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Sulfurisphaera tokodaii str. 7] Sequence ID: P50455.3 Length: 337 Range 1: 5 to 281 Score:136 bits(343), Expect:2e-35, Method:Compositional matrix adjust., Identities:100/335(30%), Positives:160/335(47%), Gaps:58/335(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I+GDGIG +I K ++ A + + Y+ IE++E+ AG++A YG+ LP ++ Sbjct 5 VALIQGDGIGPEIVSKSKRIL-AKINELYS--LPIEYIEVEAGDRALARYGE--ALPKDS 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 L+ I + + +KGP VG + V LRQ D+Y +RP + G+ + V+ Sbjct 60 LKIIDKADIILKGP----VGESAADVVVKLRQIYDMYANIRPAKSIPGIDTKYGN---VD 112 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 ++I REN+ED+Y G E AV G+K +++ + R Sbjct 113 ILIVRENTEDLYKGFEHIVSDGVAV-----------------------GMKIITRFASER 149 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 + + + +A+ R VT VHK N+M+ T+G F + V L G Sbjct 150 IAKVGLNFAL-RRRKKVTCVHKANVMRITDGLFAEACRSV---------LKG-------- 191 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 K+ ++ DA ++ P + VI T N+ GD +SD + G +GIAP AN+ Sbjct 192 -----KVEYSEMYVDAAAANLVRNPQMFDVIVTENVYGDILSDEASQIAGSLGIAPSANI 246 Query 339 SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMM 373 D LFE HG A AG++ NP + +LS MM Sbjct 247 GDKKALFEPVHGAAFDIAGKNIGNPTAFLLSVSMM 281 >RecName: Full=Homoisocitrate dehydrogenase, mitochondrial; Short=HIcDH; Flags: Precursor [Saccharomyces cerevisiae S288C] Sequence ID: P40495.1 Length: 371 Range 1: 26 to 349 Score:133 bits(335), Expect:5e-34, Method:Compositional matrix adjust., Identities:105/368(29%), Positives:176/368(47%), Gaps:51/368(13%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I I GDGIG ++ P K V++ K ++++YAG + + GK LPDET Sbjct 26 IGLIPGDGIGKEVIPAGKQVLENLNSKH---GLSFNFIDLYAGFQTFQETGK--ALPDET 80 Query 99 LEAIKE-YQVAIKGPLTTPVGG--GIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 ++ +KE Q A+ G + +P G S VALR+++ L+ +RPV+ G + + Sbjct 81 VKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG-----EKGK 135 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 ++MVI REN+ED+Y IE ++ G + K +S+ Sbjct 136 PIDMVIVRENTEDLYIKIEK-----------TYIDKATGTR-------VADATKRISEIA 177 Query 216 TSRLVRRAIQYAIDN----DRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 T R+ A+ A+ + ++T+ HK N++ ++G F++ EV Sbjct 178 TRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEV------------- 224 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 + K GQ I + I D+ + ++ P + VI NL GD +SD AA VG +G Sbjct 225 --YESNKDKYGQ-IKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLG 281 Query 332 IAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 + P AN+ + + E HG+AP AG+ NP + I S +ML +LG EAA + + ++ Sbjct 282 VVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVD 341 Query 392 GAIESKTV 399 + ++ Sbjct 342 ANLREGSI 349 >RecName: Full=Homoisocitrate dehydrogenase; Short=HICDH [Schizosaccharomyces pombe 972h-] Sequence ID: O14104.1 Length: 362 Range 1: 6 to 343 Score:131 bits(329), Expect:3e-33, Method:Compositional matrix adjust., Identities:104/378(28%), Positives:182/378(48%), Gaps:50/378(13%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLP 95 R ++ I DGIG ++ P + +++ K K K +++++ AG + GK LP Sbjct 6 RIVLGLIPADGIGKEVVPAARRLMENLPAKH---KLKFDFIDLDAGWGTFERTGK--ALP 60 Query 96 DETLEAIK-EYQVAIKGPLTTPVG--GGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 + T+E +K E A+ G + +P G S VALR+++ LY +RPV+ G Sbjct 61 ERTVERLKTECNAALFGAVQSPTHKVAGYSSPIVALRKKMGLYANVRPVKSLDGAKG--- 117 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMG------VKKIRFPETAGI 206 + V++VI REN+E +Y VK +QN G +++I + I Sbjct 118 --KPVDLVIVRENTECLY------------VKEERMVQNTPGKRVAEAIRRISEEASTKI 163 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 G + + +R + Y+I + + VT++HK N+M T+G F++ A+ Sbjct 164 GKMAFEIAKSRQKIRESGTYSI-HKKPLVTIIHKSNVMSVTDGLFRESCRH-------AQ 215 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 LD P + I + + I D+ + ++ P + V+ NL GD +SD A+ Sbjct 216 SLD--PSYA--------SINVDEQIVDSMVYRLFREPECFDVVVAPNLYGDILSDGAASL 265 Query 327 VGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLV 386 +G +G+ P AN+ D + E HG+AP AG+ NP + S +ML ++G ++AA + Sbjct 266 IGSLGLVPSANVGDNFVMSEPVHGSAPDIAGRGIANPVATFRSVALMLEFMGHQDAAADI 325 Query 387 VQGIEGAI-ESKTVTYDF 403 ++ + E K +T D Sbjct 326 YTAVDKVLTEGKVLTPDL 343 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bifidobacterium longum DJO10A] Sequence ID: B3DTF8.1 Length: 343 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bifidobacterium longum NCC2705] Sequence ID: Q8G500.1 Length: 343 Range 1: 7 to 343 Score:128 bits(321), Expect:3e-32, Method:Compositional matrix adjust., Identities:119/398(30%), Positives:177/398(44%), Gaps:71/398(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNW-LPDE 97 I I GDGIG ++ P + A+EK+ G E+ G + Y +D LP++ Sbjct 7 IAVIPGDGIGKEVTPWAQK----ALEKAAEGVADFEYENFDLG---AERYLRDGAILPED 59 Query 98 TLEAIKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 E IK + G + P + GI R L + LR LD YV LRP + + GV SP+ P Sbjct 60 EEERIKANDAILLGAVGDPRIKAGILERGLLLKLRFDLDQYVNLRPSKLYKGVTSPLANP 119 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 ++ V+ RE +E +Y G AG G + P+ + + Sbjct 120 GDIDFVVVREGTEGLYCG----AG---------------GAVRRNTPQEVATEVSINTAY 160 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R+VR A + A+ + VTLVHK N++ G W Sbjct 161 GVERVVRYAFKLAMKRKK-HVTLVHKKNVLVNA----------------------GDMWQ 197 Query 275 VFENPKTGQK---ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 + K G++ +T DA ++ P+ + VI T NL GD ++D + VGG+G Sbjct 198 RIVD-KVGEEYPEVTHDYQHIDAATIFLVSDPSRFDVILTDNLFGDILTDEAGSVVGGVG 256 Query 332 IAPGA--NLSDTV-GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQ 388 + N SD +FE HG+AP AGQ+K NP + ILSA M+L +LG+ +AA + Sbjct 257 YSASGCINASDEFPSMFEPIHGSAPDIAGQNKANPTAAILSAAMLLEHLGFDDAAKKIHT 316 Query 389 GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +E IE G+ ST Q GK I+ + Sbjct 317 AVEADIEE-----------LGSTVRSTDQVGKDILARM 343 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Nocardia farcinica IFM 10152] Sequence ID: Q5YRX2.1 Length: 335 Range 1: 6 to 302 Score:127 bits(320), Expect:4e-32, Method:Compositional matrix adjust., Identities:110/347(32%), Positives:156/347(44%), Gaps:57/347(16%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ V+D V +E E G K + + LPD L Sbjct 6 IPGDGIGPEVIAEALKVLDVVVPG-------VEKTEYDLGAK--RYHATGEILPDSVLPE 56 Query 102 IKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 ++E+ + G + P V G+ R L + R +LD +V LRP R FTGV SP+ ++ Sbjct 57 LREHDAILLGAIGDPSVPSGVLERGLLLRTRFELDHHVNLRPSRLFTGVRSPLAGAPDID 116 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 V+ RE +E Y G G ++R P + ++ G R Sbjct 117 FVVVREGTEGPYTGTG-------------------GAIRVRTPHEVATEVSTNTRFGIER 157 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 +VR A A R +TLVHK N++ F A W + V E GA E Sbjct 158 VVRYAFAKA-QARRKHLTLVHKTNVLTF---AGSLW--QRTVDEVGA-----------EF 200 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 P ++T+ DA ++ P + VI T NL GD I+D AA GGIG+A N+ Sbjct 201 P----EVTVAYQHIDAATIHMVTDPGRFDVIVTDNLFGDIITDLAAAVSGGIGLAASGNI 256 Query 339 SDTVG----LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE 381 D G +FE HG+AP AGQ K +P + ILS ++L +LG E Sbjct 257 -DASGTNPSMFEPVHGSAPDIAGQSKADPTAAILSVSLLLNHLGDTE 302 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Corynebacterium glutamicum R] Sequence ID: A4QDP9.1 Length: 340 Range 1: 3 to 336 Score:127 bits(318), Expect:7e-32, Method:Compositional matrix adjust., Identities:117/393(30%), Positives:180/393(45%), Gaps:66/393(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ V++A + IE + G A + L DE Sbjct 3 LAVIGGDGIGPEVTAEALKVLNAV-------RDDIETTDYDLG--ARRYLKNGELLTDED 53 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 L +++E+ AI P + P G R L + +R LD +V LRP + + GV SP++ P Sbjct 54 LASLREHDAILLGAIGAPGSVPPGILERGLLLKMRFALDHHVNLRPSKLYDGVESPLRNP 113 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 K++ V+ RE +E Y G G V + + NE V ++ Sbjct 114 GKIDFVVVREGTEGAYTG----NGGAIRVGTAHEIANETSVN---------------TRY 154 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R++R A + A + R +TLVHK N++ G ++ EVA KE+ +D H Sbjct 155 GAERVIRYAFELA-QSRRKKLTLVHKTNVLVHGGGLWQRTVDEVA-KEYPEVAVDYN--H 210 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 + DA ++ P+ + VI T NL GD ++D A GGIG+A Sbjct 211 I-----------------DAATIYLITDPSRFDVIVTDNLFGDILTDEAGAVSGGIGLAA 253 Query 335 GANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 N+ T +FE HG+AP AGQ +P + ILSA M+LR+LG ++ A IE Sbjct 254 SGNIDATGTNPSMFEPVHGSAPDIAGQGIADPTAAILSAAMLLRHLGDEDNA----VRIE 309 Query 392 GAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 AI + D ++ +ST++ G I+K Sbjct 310 TAIAADVAGRD------NSQPISTTEVGDRIVK 336 >RecName: Full=3-isopropylmalate dehydrogenase [Haloferax volcanii DS2] Sequence ID: D4GYE8.1 Length: 324 Range 1: 5 to 324 Score:125 bits(314), Expect:2e-31, Method:Compositional matrix adjust., Identities:109/388(28%), Positives:168/388(43%), Gaps:68/388(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I I GDGIG ++ P +V+ A + E++E AG+ + G+ LP ET Sbjct 5 IVVIPGDGIGAEVIPAAVDVLKAVGD--------FEFVEADAGDHVKEETGE--ALPQET 54 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 + E + G G + + LR +D +V +RP + + GV + PE + Sbjct 55 YDLAAEADATLFGA----AGETAADVILPLRTAVDSFVNVRPAKAYPGVDA--LRPE-TD 107 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 +V REN+E +Y+G E R E + V+ + R Sbjct 108 LVFLRENTEGVYSGHED-----------------------RLSEDLSTLTRVVTTSASER 144 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 L A Y + + S + HK N+M+ T+G F+D VA + Sbjct 145 LAEYACDY-VGGEGGSFQVAHKANVMRETDGRFRDAAVAVADE----------------- 186 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 + + ++V+ DAF ++ L P ++ I NL GD +SD A VGG+G+ P AN+ Sbjct 187 ----RGVETEEVLMDAFATRVCLDPTQFDTIVCPNLAGDVLSDLAAGLVGGLGLLPSANI 242 Query 339 SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEGAIESKT 398 LFE HG+AP AG+ NP + ILSA M+L YL + AD V +EG + Sbjct 243 GPDAALFEPVHGSAPDIAGEGIANPAATILSAAMLLDYLDHEAEADRVRSAVEGVLADGP 302 Query 399 VTYDFARLMTGAKEVSTSQFGKAIIKHI 426 T D + ST AI+ + Sbjct 303 RTPDL------GGDASTEDVTAAILDRL 324 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Corynebacterium glutamicum ATCC 13032] Sequence ID: P94631.1 Length: 340 Range 1: 3 to 336 Score:125 bits(315), Expect:2e-31, Method:Compositional matrix adjust., Identities:117/393(30%), Positives:180/393(45%), Gaps:66/393(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ V++A + IE + G A + L DE Sbjct 3 LAVIGGDGIGPEVTAEALKVLNAV-------RDDIETTDYDLG--ARRYLKNGELLTDED 53 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 L +++E+ AI P + P G R L + +R LD +V LRP + + GV SP++ P Sbjct 54 LASLREHDAILLGAIGAPGSVPPGILERGLLLKMRFALDHHVNLRPSKLYDGVESPLRNP 113 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 K++ V+ RE +E Y G G V + + NE V ++ Sbjct 114 GKIDFVVVREGTEGAYTG----NGGAIRVGTPHEIANETSVN---------------TRY 154 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R++R A + A + R +TLVHK N++ G ++ EVA KE+ +D H Sbjct 155 GAERVIRYAFELA-QSRRKKLTLVHKTNVLVHGGGLWQRTVDEVA-KEYPEVAVDYN--H 210 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 + DA ++ P+ + VI T NL GD ++D A GGIG+A Sbjct 211 I-----------------DAATIYLVTDPSRFDVIVTDNLFGDILTDEAGAVSGGIGLAA 253 Query 335 GANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 N+ T +FE HG+AP AGQ +P + ILSA M+LR+LG ++ A IE Sbjct 254 SGNIDATGTNPSMFEPVHGSAPDIAGQGIADPTAAILSAAMLLRHLGDEDNA----VRIE 309 Query 392 GAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 AI + D ++ +ST++ G I+K Sbjct 310 TAIAADVAGRD------NSQPISTTEVGDRIVK 336 >RecName: Full=Isocitrate/homoisocitrate dehydrogenase; Short=HICDH; AltName: Full=Beta-decarboxylating dehydrogenase [Pyrococcus horikoshii OT3] Sequence ID: O59394.2 Length: 345 Range 1: 4 to 296 Score:125 bits(314), Expect:2e-31, Method:Compositional matrix adjust., Identities:104/359(29%), Positives:167/359(46%), Gaps:74/359(20%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I+GDGIG V+DAA+ + KI++ E G K YG + +E Sbjct 4 VAVIKGDGIG-------PEVIDAAIRVVKSVTDKIKFYEFEGGLSVFKKYGVP--IREED 54 Query 99 LEAIKEYQVAIKGPLTTPVG-GGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKV 157 LE I++ + G TTP +SL + LR++LDLY LR + F + Sbjct 55 LEEIRKMDAILFGATTTPFDVPRYKSLIITLRKELDLYANLRIIPNF---------KLRK 105 Query 158 NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTS 217 ++I RENSE +Y+G G+ ++ K+++F + ++++G Sbjct 106 EIIIVRENSEGLYSG----EGAYDSNKVVDF--------------------RIITRKGAE 141 Query 218 RLVRRAIQYAIDNDRDS-VTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ + A++ A DR + +T VHK NI++ ++ F+ ++A KE Sbjct 142 RIAKFAVKLA--KDRSTFLTFVHKANILE-SDRFFRKIVLDIARKE-------------- 184 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 + +++ I D+F +++ P +I + N+ GD +SD G IGI P Sbjct 185 -------DVKVREEIVDSFTIKLVKDPWNLGIILSENMFGDILSDLATIHAGSIGIVPSG 237 Query 337 NLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG------WKEAADLVVQG 389 N + + LFE HG+AP AG+ NP ILSA MML YLG WK V +G Sbjct 238 NYGEDIALFEPIHGSAPDIAGKGIANPIGAILSAAMMLDYLGLDGSIIWKAVGRYVRRG 296 >RecName: Full=Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [Saccharomyces cerevisiae S288C] Sequence ID: P28834.2 Length: 360 Range 1: 28 to 357 Score:125 bits(314), Expect:3e-31, Method:Compositional matrix adjust., Identities:107/396(27%), Positives:178/396(44%), Gaps:71/396(17%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATK--VYGKDNW 93 R + I GDG+G +I ++ + +A I+W I + K VY Sbjct 28 RFTVTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDHKEGVY----- 75 Query 94 LPDETLEAIKEYQVAIKGPLTTPVG-GGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 E +E++K ++ +KG TP G SLNVALR+QLD+Y + + GV + + Sbjct 76 ---EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT--R 130 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 P+ +++++ REN+E ++G+E + P V+ +K ++ Sbjct 131 IPD-IDLIVIRENTEGEFSGLEHES-VPGVVE----------------------SLKVMT 166 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 + T R+ R A +A +R SVT VHK NIMK +G F++ E+ KE+ Sbjct 167 RPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY--------- 217 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 I + +I D Q + +P ++ V+ T ++ G + + AA +GG G+ Sbjct 218 ----------PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGL 267 Query 333 APGANLSDTVGLFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 GAN +FE + GQ+ NP ++ILS+ +ML +LG E A + + + Sbjct 268 VAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVH 327 Query 392 GAI-ESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 I E K T D ST+ F II + Sbjct 328 ETIAEGKHTTRDI------GGSSSTTDFTNEIINKL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Leifsonia xyli subsp. xyli str. CTCB07] Sequence ID: Q6AEP6.1 Length: 357 Range 1: 10 to 350 Score:125 bits(314), Expect:4e-31, Method:Compositional matrix adjust., Identities:118/398(30%), Positives:177/398(44%), Gaps:74/398(18%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ +DA S + + + Y A + + L D+ L A Sbjct 10 IPGDGIGPEVIAEAVKALDAVTAGS-----GLAFQKTYFSLGADRYLATGDVLTDDDLAA 64 Query 102 IKEYQV----AIKGPLTTPVGGGI---RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 I+ + A+ G P G R L + LR LD YV LRP F G+ SP+ P Sbjct 65 IRGHDAILLGAVGGRPGDPRLAGANVERGLLLRLRFSLDHYVNLRPTTLFPGIASPLAAP 124 Query 155 EKVNMVIFRENSEDIYAGIEWP--AGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 +V+ V+ RE +E Y G G+P V NE+ V + Sbjct 125 GEVDFVVVREGTEGQYVGNGGAIRPGTPHEVA------NEVSVN---------------T 163 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 G R+VR A + A R +TLVHK N++ F +K +A Sbjct 164 AYGVERVVRYAFEQA-GQRRKKLTLVHKTNVLTFAGSLWKRIVDALAA------------ 210 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 E+P+ + + + DA ++ PA + VI T NL GD ++D AA GGIG+ Sbjct 211 ----EHPE----VAVDYLHVDAATIFLVTDPARFDVIVTDNLFGDILTDLAAAISGGIGL 262 Query 333 APGANLSDTVG----LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQ 388 A N+ + VG +FE HG+AP AG+ + +P + ILS ++LR+LG + A+ V Sbjct 263 AASGNI-NPVGEFPSMFEPVHGSAPDIAGEQRADPTAAILSVALLLRHLGERPLAERV-- 319 Query 389 GIEGAIESKTVTYDFA----RLMTGAKEVSTSQFGKAI 422 + VT D A ++ T ++ +TSQ G AI Sbjct 320 -------ERAVTTDLAARSGQMATASQTRTTSQIGDAI 350 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088] Sequence ID: B7GUI8.1 Length: 343 Range 1: 7 to 343 Score:124 bits(312), Expect:5e-31, Method:Compositional matrix adjust., Identities:118/398(30%), Positives:176/398(44%), Gaps:71/398(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNW-LPDE 97 I I GDGIG ++ P + A+EK+ G E+ G + Y +D LP++ Sbjct 7 IAVIPGDGIGKEVTPWAQK----ALEKAAEGVADFEYENFDLG---AERYLRDGAILPED 59 Query 98 TLEAIKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 IK + G + P + GI R L + LR LD YV LRP + + GV SP+ P Sbjct 60 EEGRIKANDAILLGAVGDPRIKAGILERGLLLKLRFDLDQYVNLRPSKLYKGVTSPLANP 119 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 ++ V+ RE +E +Y G AG G + P+ + + Sbjct 120 GDIDFVVVREGTEGLYCG----AG---------------GAVRRNTPQEVATEVSINTAY 160 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R+VR A + A+ + VTLVHK N++ G W Sbjct 161 GVERVVRYAFKLAMKRKK-HVTLVHKKNVLVNA----------------------GDMWQ 197 Query 275 VFENPKTGQK---ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 + K G++ +T DA ++ P+ + VI T NL GD ++D + VGG+G Sbjct 198 RIVD-KVGEEYPEVTHDYQHIDAATIFLVSDPSRFDVILTDNLFGDILTDEAGSVVGGVG 256 Query 332 IAPGA--NLSDTV-GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQ 388 + N SD +FE HG+AP AGQ+K NP + ILSA M+L +LG+ +AA + Sbjct 257 YSASGCINASDEFPSMFEPIHGSAPDIAGQNKANPTAAILSAAMLLEHLGFDDAAKKIHT 316 Query 389 GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +E IE G+ ST Q GK I+ + Sbjct 317 AVEADIEE-----------LGSTVRSTDQVGKDILARM 343 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Clavibacter michiganensis subsp. michiganensis NCPPB 382] Sequence ID: A5CPZ4.1 Length: 355 Range 1: 56 to 349 Score:122 bits(305), Expect:6e-30, Method:Compositional matrix adjust., Identities:99/341(29%), Positives:149/341(43%), Gaps:57/341(16%) Query 94 LPDETLEAIKEYQVAIKG-----PLTTPVGGGI--RSLNVALRQQLDLYVCLRPVRYFTG 146 L D L A+ ++ + G P + GGI R L + LR D Y+ LRP G Sbjct 56 LTDSDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTTLLPG 115 Query 147 VPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 V SP+ +P +V+ V+ RE +E YAG GV + Sbjct 116 VTSPLASPGEVDFVVVREGTEGPYAG-------------------NGGVLRRGTEHEIAT 156 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + + G R VR A A +R VTLVHK N++ F ++ VA Sbjct 157 EVSVNTAHGVERTVRFAFDLASKRERKRVTLVHKTNVLTFAGSLWQRTVDRVAA------ 210 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E+P + + + DA + ++ P+ + VI + NL GD I+D AA Sbjct 211 ----------EHPD----VAVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIITDLAAAI 256 Query 327 VGGIGIAPGANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAA 383 GGIG+A N++ T +FE HG+AP AGQ K +P + ILS ++L +LG EAA Sbjct 257 SGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVSLLLDHLGLPEAA 316 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 V + + ++ R ST++ G A+I+ Sbjct 317 ARVTAAVSADLAARAAGDPAPR--------STAEVGDAVIR 349 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Corynebacterium efficiens YS-314] Sequence ID: Q8FPV5.2 Length: 340 Range 1: 3 to 300 Score:120 bits(300), Expect:2e-29, Method:Compositional matrix adjust., Identities:106/347(31%), Positives:158/347(45%), Gaps:56/347(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG V D A++ A + IE ++ G A + L DE Sbjct 3 LAVIGGDGIG-------PEVTDEALKVLRALRADIETTDLDLG--ARRYLRNGELLTDED 53 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 L ++E+ AI P + P G R L + LR LD +V LRP + + GV SP+K P Sbjct 54 LALLREHDAILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNP 113 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 +++ V+ RE +E Y G G V + NE V ++ Sbjct 114 GEIDFVVVREGTEGAYTG----NGGAIRVGTPHETANETSVN---------------TRY 154 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R++R A + A + R +TLVHK N++ G ++ EVA +E+ Sbjct 155 GAERVIRYAFELA-QSRRRHLTLVHKTNVLVHGGGLWQRTVDEVA-REY----------- 201 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 ++T+ DA ++ P+ + VI T NL GD ++D A GGIG+A Sbjct 202 --------PEVTVDYNHIDAATIYLVTDPSRFDVIVTDNLFGDILTDEAGAISGGIGLAA 253 Query 335 GANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG 378 N+ T +FE HG+AP G+ +P + ILSA MMLR+LG Sbjct 254 SGNIDATGTNPSMFEPVHGSAPDIMGKGIADPTAAILSAAMMLRHLG 300 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Clavibacter sepedonicus] Sequence ID: B0RIP4.1 Length: 355 Range 1: 56 to 349 Score:120 bits(301), Expect:2e-29, Method:Compositional matrix adjust., Identities:107/342(31%), Positives:153/342(44%), Gaps:59/342(17%) Query 94 LPDETLEAIKEYQVAIKG-----PLTTPVGGGI--RSLNVALRQQLDLYVCLRPVRYFTG 146 L D L A+ ++ + G P + GGI R L + LR D Y+ LRP G Sbjct 56 LTDSDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPG 115 Query 147 VPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 V SP+ P +V+ V+ RE +E YAG GV + Sbjct 116 VASPLAAPGQVDFVVVREGTEGPYAG-------------------NGGVLRRGTEHEIAT 156 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + + G R VR A + A DR VTLVHK N++ F ++ VA Sbjct 157 EVSVNTAHGVERTVRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAA------ 210 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E+P +T+ + DA + ++ P+ + VI + NL GD I+D AA Sbjct 211 ----------EHPD----VTVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIITDLAAAI 256 Query 327 VGGIGIAPGANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAA 383 GGIG+A N++ T +FE HG+AP AGQ K +P + ILS ++L +LG EAA Sbjct 257 SGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVALLLDHLGLSEAA 316 Query 384 DLVVQGIEGAIESKTVTYDFARLMTG-AKEVSTSQFGKAIIK 424 A S V+ D A TG A ST++ G AI++ Sbjct 317 ---------ARVSAAVSDDLAARATGDAAPRSTAEVGDAILR 349 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Streptomyces griseus subsp. griseus NBRC 13350] Sequence ID: B1VZ57.1 Length: 347 Range 1: 6 to 341 Score:119 bits(298), Expect:5e-29, Method:Compositional matrix adjust., Identities:112/396(28%), Positives:173/396(43%), Gaps:68/396(17%) Query 35 DRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWL 94 D +IP GDGIG ++ V++A + + K+E E G A + + + L Sbjct 6 DLAVIP---GDGIGQEVVAQGLKVLNAVLPQDV----KLETKEYDLG--AQRWHRTGDTL 56 Query 95 PDETLEAIKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPV 151 PD LEA+K + + G + P V G+ R L + LR D ++ LRP + F +P+ Sbjct 57 PDAELEALKGHDAILLGAIGDPSVPSGVLERGLLLKLRFAFDHFINLRPSKLFPNTATPL 116 Query 152 KTPEKVNMVIFRENSEDIYAGI--EWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIK 209 ++ V+ RE +E Y G G+P V L GV+ Sbjct 117 AGRPDIDFVVVREGTEGPYTGNGGSLRTGTPAEVATEVSLNTAYGVE------------- 163 Query 210 PVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLD 269 R+VR A + A R +TLVHK N++ + +K+ +VA Sbjct 164 --------RVVRDAFERAAARPRKKLTLVHKNNVLVYAGHLWKNTFDKVAA--------- 206 Query 270 GGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGG 329 E P+ D F+ Q P + VI T NL GD ++D AA GG Sbjct 207 -------EYPQVSTDYLHVDAATIFFVTQ----PERFDVIVTDNLFGDILTDLAAAVSGG 255 Query 330 IGIAPGANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLV 386 IG+A N++ T +FE HG+AP AGQ K +P + +LS ++LR+LG++ A Sbjct 256 IGLAASGNINPTGAFPSMFEPVHGSAPDIAGQGKADPTATVLSVALLLRHLGYEAEA--- 312 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 IE A+ + D G+ +T + G A+ Sbjct 313 -ARIEDAVSADLAERD------GSVARTTDEIGDAL 341 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Streptomyces coelicolor A3(2)] Sequence ID: O86504.1 Length: 347 Range 1: 10 to 312 Score:117 bits(294), Expect:2e-28, Method:Compositional matrix adjust., Identities:102/348(29%), Positives:158/348(45%), Gaps:51/348(14%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ V+ A + + K+E E G A + + L D L+A Sbjct 10 IPGDGIGQEVVAEGLKVLSAVLPQDV----KLETKEFDFG--ARRYHATGETLTDADLDA 63 Query 102 IKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 +K + + G + P V G+ R + LR D +V LRP + GV +P+ +++ Sbjct 64 LKAHDAILLGAIGDPSVPSGVLERGFLLKLRFAFDHHVNLRPSKLLPGVATPLAGQPEID 123 Query 159 MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSR 218 V+ RE +E Y G N ++K E A + + G R Sbjct 124 FVVVREGTEGPYTG------------------NGGTIRKGTEHEVA-TEVSVNTAYGVER 164 Query 219 LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFEN 278 +VR A A R +TLVHK N++ F + + +VA E Sbjct 165 VVRDAFARAQARPRKKLTLVHKNNVLTFAGHLWTNIFNKVAA----------------EY 208 Query 279 PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL 338 P+ +T + DA ++ PA + VI T NL GD I+D AA GGIG+A N+ Sbjct 209 PE----VTTDYLHVDAATIFLVTDPARFDVIVTDNLFGDIITDLAAAVSGGIGVAASGNI 264 Query 339 S---DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAA 383 + D +FE HG+AP AGQ K +P + +LS ++LR+LG+++ A Sbjct 265 NPSGDFPSMFEPVHGSAPDIAGQGKADPTATVLSVALLLRHLGYEDEA 312 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Beutenbergia cavernae DSM 12333] Sequence ID: C5C2I9.1 Length: 347 Range 1: 7 to 345 Score:116 bits(291), Expect:4e-28, Method:Compositional matrix adjust., Identities:109/394(28%), Positives:170/394(43%), Gaps:61/394(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG ++ V+DAA+ + R + A + + L DE Sbjct 7 LAVVAGDGIGPEVVAEGLKVLDAALAGTDVTVRTTAY-----DLGAARWHATGETLTDED 61 Query 99 LEAIKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 L A+ ++ + G + P V G+ R L + LR D YV LRP R + GV +P+ Sbjct 62 LAALAQHDAILLGAIGDPGVPSGVLERGLLLKLRFAFDHYVNLRPSRLYPGVATPLAKGG 121 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 V+ V+ RE +E Y G G V + + NE+ V + G Sbjct 122 DVDFVVVREGTEGPYVG----NGGAIRVGTPHEIANEVSVN---------------TAFG 162 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 R+VR A A R +TLVHK N++ A W V+ GA+ D Sbjct 163 VERVVRDAFARADARPRKKLTLVHKHNVLVH---AGHLW--RRTVEAVGAEFPD------ 211 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 + + + DA ++ PA + V+ T NL GD ++D AA GGIG+A Sbjct 212 ---------VAVDYLHVDAATIFLVTDPARFDVVVTDNLFGDILTDLAAAITGGIGLAAS 262 Query 336 ANLSDTVG---LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEG 392 N++ +FE HG+AP AGQ K +P + +LS ++L +LG E A + +E Sbjct 263 GNINPDRAFPSMFEPVHGSAPDIAGQGKADPTATVLSVALLLEHLGLTEQAARITAAVES 322 Query 393 AIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 I + G+ ST++ G A+ + Sbjct 323 DIVER-----------GSAVRSTAEVGDALAARV 345 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Thermobifida fusca YX] Sequence ID: Q47SB4.1 Length: 354 Range 1: 8 to 340 Score:116 bits(291), Expect:6e-28, Method:Compositional matrix adjust., Identities:109/379(29%), Positives:171/379(45%), Gaps:65/379(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ V+ A + ++ E G A + + LPD Sbjct 8 LAVIPGDGIGPEVVAEGLKVLSAVAPRH---GLTLDTTEYELG--AQRWHATGEVLPDAV 62 Query 99 LEAIKEYQVAIKGPL---TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK--T 153 E ++++ + G + T P G R L + LR YV LRPVR + GV +P+ Sbjct 63 EEELRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGVA 122 Query 154 PEKVNMVIFRENSEDIYAGIE--WPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPV 211 PE ++M++ RE +E YAG+ G+P + + + +GV+ Sbjct 123 PEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVE--------------- 167 Query 212 SKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 R+VR A A + +TLVHK N++ + A + W + V+E GA Sbjct 168 ------RVVRYAFAKAAERPCHKLTLVHKDNVLTY---AGELW--QRVVREVGA------ 210 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 E P ++ + + DA + +P + V+ T NL GD I+D AA GGIG Sbjct 211 -----EYP----QVEVDYLHVDAATMFFVTQPRRFDVVVTDNLFGDIITDLGAAVAGGIG 261 Query 332 IAPGANLS---DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE------- 381 +A N++ D +FE HG+AP AGQ K +P + ILS +ML +LG+ + Sbjct 262 LAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATILSVSLMLEHLGYADAAAQIDQ 321 Query 382 --AADLVVQGIEGAIESKT 398 A DL + G + S T Sbjct 322 AVAEDLQERAKNGGVRSTT 340 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Streptomyces avermitilis MA-4680 = NBRC 14893] Sequence ID: Q82JN6.1 Length: 347 Range 1: 10 to 308 Score:115 bits(288), Expect:1e-27, Method:Compositional matrix adjust., Identities:100/346(29%), Positives:154/346(44%), Gaps:55/346(15%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ V+ AA+ K+E E G A + + L D L+A Sbjct 10 IPGDGIGQEVVAQGLKVLSAALPSDV----KLETKEFDFG--ARRYHATGETLTDADLDA 63 Query 102 IKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 +K++ + G + P V G+ R + LR D +V LRP + GV +P+ +++ Sbjct 64 LKQHDAILLGAIGDPSVPSGVLERGFLLKLRFAFDHHVNLRPSKLLPGVETPLAGQPEID 123 Query 159 MVIFRENSEDIYAGI--EWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 V+ RE +E Y G G+P AV L G++ Sbjct 124 FVVVREGTEGPYTGNGGTIRTGTPHAVATEVSLNTAFGIE-------------------- 163 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+VR A A R + LVHK N++ + D +V +EF Sbjct 164 -RVVRDAYARAQARPRKKLALVHKNNVLVHAGHLWTDIFNKVG-EEF------------- 208 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 +T + + DA ++ +P + VI T NL GD I+D AA GGIG+A Sbjct 209 ------PDVTTEYMHVDAATIYLVTQPERFDVIVTDNLFGDIITDLAAAISGGIGVAASG 262 Query 337 NLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGW 379 N++ + +FE HG+AP AGQ K +P + ILS ++LR+LG+ Sbjct 263 NINPSGAYPSMFEPVHGSAPDIAGQGKADPSATILSVALLLRHLGY 308 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Corynebacterium urealyticum DSM 7109] Sequence ID: B1VG35.1 Length: 339 Range 1: 3 to 312 Score:113 bits(283), Expect:5e-27, Method:Compositional matrix adjust., Identities:106/362(29%), Positives:160/362(44%), Gaps:62/362(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I+GDGIG+++ V+ A + +E E G A + L D Sbjct 3 LAVIDGDGIGVEVTAEALKVLKAV-------RDDVETTEYDLG--ARRYLRNGETLTDAD 53 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 LE++K++ AI P T P G R L + LR +LD V LRP + + G SP+K Sbjct 54 LESLKQHDAILLGAIGDPRTVPAGVLERGLLLPLRFKLDHAVNLRPSKLYPGASSPLKNA 113 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 +++ V+ RE +E +Y G N +++ E A VS+ Sbjct 114 GEIDFVVVREGTEGLYCG------------------NGGTLREGTDHEVA----SEVSQN 151 Query 215 ---GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 G R+VR A + A + R +T VHK N++ G E KEF +D Sbjct 152 TWFGVERVVRDAFRRAQER-RKKLTWVHKTNVL-VNAGGLWQRAIETIGKEFPDVEVDYN 209 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 H+ DA ++ P+ Y VI T NL GD ++D A GGIG Sbjct 210 --HI-----------------DAATIYMVTDPSRYDVIVTDNLFGDILTDLAGAVTGGIG 250 Query 332 IAPGANLSDTVG---LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQ 388 +A N+ T +FE HG+AP AGQ +P + ILS +MLR+LG + A+ + + Sbjct 251 LAASGNIDPTHNNPSMFEPVHGSAPDIAGQGIADPCAAILSVALMLRHLGDEANAEKIEK 310 Query 389 GI 390 + Sbjct 311 AV 312 >RecName: Full=D-malate dehydrogenase [decarboxylating]; AltName: Full=D-malate degradation protein A; AltName: Full=D-malate oxidase [Escherichia coli K-12] Sequence ID: P76251.1 Length: 361 Range 1: 10 to 360 Score:114 bits(284), Expect:6e-27, Method:Compositional matrix adjust., Identities:109/400(27%), Positives:173/400(43%), Gaps:63/400(15%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ P V+ AA E+ + E ME +A + +GK +PD+ E Sbjct 10 IPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQME-WASCEYYSHHGK--MMPDDWHEQ 65 Query 102 IKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPV--KTPE 155 + + A+ P T P + + R++ D YV LRPVR F GVP P+ K P Sbjct 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 ++ + REN+E Y+ + ++ ++E+ +++ F ++ G Sbjct 126 DIDFYVVRENTEGEYSSL--------GGRVNEGTEHEVVIQESVF-----------TRRG 166 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 R++R A + A R ++T K N + + W V + H+ Sbjct 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAIS---MPYWDERVEAMAENYPEIRWDKQHI 223 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 D + +++P + V+ NL GD +SD A G IGIAP Sbjct 224 -----------------DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Query 336 ANLSDTV---GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-----WKEAADLVV 387 ANL+ LFE HG+AP G++ NP + I + MML +LG +++A + ++ Sbjct 267 ANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGIL 326 Query 388 QGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 IE I T D M G +T Q AI K IL Sbjct 327 AAIEEVIAHGPKTPD----MKG--NATTPQVADAICKIIL 360 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821] Sequence ID: Q5NPQ9.1 Length: 349 Range 1: 3 to 348 Score:113 bits(282), Expect:8e-27, Method:Compositional matrix adjust., Identities:112/402(28%), Positives:182/402(45%), Gaps:70/402(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I ++ A V ++IE+ E G A KV G + LP+ET Sbjct 3 IALLAGDGIGPEITAEAVKILKAVV------GQEIEFDEALIGGAAWKVTG--SPLPEET 54 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYFTGVPSPVK 152 L+ K + G + P + R+L + LR++LDL+ LRP R F + + Sbjct 55 LKLCKNSDAILFGSVGDPECDHLERALRPEQAILGLRKELDLFANLRPARLFPELQAESP 114 Query 153 TPEKV----NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 E + +++I RE + D+Y G +P + + + E G +R+ E + Sbjct 115 LKENIVTGTDLMIVRELTGDVYFG------TPRGQRKDDQNRRE-GFDTMRYNEDE---V 164 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 K +++ G R+ ++ + K N+++ ++ Sbjct 165 KRIARIGFETARSRS---------GNLCSIDKSNVLETSQ-------------------- 195 Query 269 DGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 W V E + + + + D Q++ P ++ VI T NL GD +SD +A Sbjct 196 ---LWRTVVLEIAQEYPDVELSHMYVDNAAMQLVRAPDQFDVIVTGNLFGDILSDLASAC 252 Query 327 VGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEA-AD 384 VG IG+ P A+L S+ GL+E HG+AP AG K NP + ILS MMLRY +EA AD Sbjct 253 VGSIGLLPSASLNSEGKGLYEPIHGSAPDIAGLGKANPLATILSGAMMLRYSLKREADAD 312 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + + A+E T D MT TS+ G A++ + Sbjct 313 RIEKAVSTALEKGARTADLGGKMT------TSEMGNAVLAAL 348 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Corynebacterium aurimucosum ATCC 700975] Sequence ID: C3PFX5.1 Length: 339 Range 1: 3 to 319 Score:113 bits(282), Expect:8e-27, Method:Compositional matrix adjust., Identities:103/367(28%), Positives:164/367(44%), Gaps:58/367(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ V+ A ++ +E + G A + L D Sbjct 3 LAVIGGDGIGPEVTAEALKVLRAV-------RQDVEVTDYDLG--ARRYLRNGELLSDAD 53 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 +++E+ AI P P G R L + +R LD +V LRP + + SP+ P Sbjct 54 FASLREHDAILLGAIGAPGEVPPGVLERGLLLKMRFALDHHVNLRPSKLYPTSTSPLANP 113 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 ++ V+ RE +E +Y G L ++E+ + + ++ Sbjct 114 GDIDFVVVREGTEGLYCG--------NGGTLREGTEHEVASE-----------VSQNTRF 154 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R+VR A Q A+ R VTLVHK N++ G ++ EVA +EF Sbjct 155 GVERVVRDAFQRAMGR-RKHVTLVHKTNVLVNAGGLWQRTVNEVA-QEF----------- 201 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 ++T+ DA ++ PA Y VI T NL GD ++D A GGIG+A Sbjct 202 --------PEVTVDYNHIDAATIYMVTDPARYDVIVTDNLFGDILTDLAGAVTGGIGLAA 253 Query 335 GANLSDTVG----LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGI 390 N+ D G +FE HG+AP AG+ +P + ILSA M+LR+LG +E A + + + Sbjct 254 SGNI-DASGANPSMFEPVHGSAPDIAGKGIADPTAAILSAAMLLRHLGDEENAVRIEEAV 312 Query 391 EGAIESK 397 + ++ Sbjct 313 AADVSAR 319 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Corynebacterium jeikeium K411] Sequence ID: Q4JUQ0.1 Length: 338 Range 1: 3 to 337 Score:112 bits(279), Expect:2e-26, Method:Compositional matrix adjust., Identities:106/395(27%), Positives:170/395(43%), Gaps:67/395(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ A++ +A + +E + G A + L DE Sbjct 3 LAVIAGDGIGTEVTA-------EALKVLHALRDDVETTDYDLG--ARRYLRNGELLTDED 53 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 L++++E+ AI P T P G R L + LR +LD V LRP + + G SP+ P Sbjct 54 LDSLREHDAILLGAIGDPRTVPAGVLERGLLLPLRFKLDHAVNLRPSKLYPGSSSPLANP 113 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 ++ V+ RE +E +Y G G + + + Sbjct 114 GDIDFVVVREGTEGLYCG-------------------NGGTLRAGTDYEVASEVSQNTYY 154 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R+VR A + A + R +T VHK N++ G+ E +E+ +D H Sbjct 155 GVERVVRDAFERA-QSRRKKLTWVHKTNVL-VNAGSLWQRAIETVGQEYPEVQVDYN--H 210 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 + DA ++ +P EY VI T NL GD ++D A GGIG+A Sbjct 211 I-----------------DAATIYMVTKPQEYDVIVTDNLFGDILTDLAGAVTGGIGLAA 253 Query 335 GANLSDTV---GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 N+ + +FE HG+AP AGQ +P + ILS +MLR+LG D + IE Sbjct 254 SGNIDPSRKNPSMFEPVHGSAPDIAGQGIADPCAAILSVALMLRHLG----DDANAERIE 309 Query 392 GAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 A+ ++ + D V T++ G ++ ++ Sbjct 310 AAVLAEAGSRD-------GGPVKTAEVGDRVVANL 337 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bacillus licheniformis DSM 13 = ATCC 14580] Sequence ID: Q65GI9.2 Length: 370 Range 1: 5 to 345 Score:110 bits(276), Expect:8e-26, Method:Compositional matrix adjust., Identities:117/402(29%), Positives:182/402(45%), Gaps:86/402(21%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVE--KSYAGKRKIEWMEIYAGEKATKVYGKDNWLPD 96 I + GDGIG V+DAAV+ KS A + E+ Y + LP+ Sbjct 5 IALLPGDGIG-------PEVLDAAVDVLKSVAEHYQHEFEFEYGLIGGAAIDEAGAPLPE 57 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLN----------VALRQQLDLYVCLRPVRYFTG 146 ET+ A K A L VGG N +A+R+QLDL+ LRPV+ F Sbjct 58 ETVAACK----AADAILLGAVGGPKWDQNPSELRPEKGLLAIRKQLDLFANLRPVKVFES 113 Query 147 V--PSPVKTP--EKVNMVIFRENSEDIYAGIEWPA-------GSPEAVKLINFLQNEMGV 195 + SP+KT E V+ VI RE + +Y G P+ G EAV + + ++EM Sbjct 114 LAGASPLKTEYIEGVDFVIVRELTGGLYFG--KPSEQYVNQNGEEEAVDTLFYKKSEM-- 169 Query 196 KKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWG 255 R++R A Q A + + VT V K N+++ ++ ++ Sbjct 170 ---------------------ERVIREAFQMA-QSRKGKVTSVDKANVLESSK-LWRKTA 206 Query 256 YEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLN 315 EVA KEF + ++ ++ D Q++ P ++ +I T N+ Sbjct 207 EEVA-KEF-------------------PDVKLEHMLVDNAAMQLIYAPGQFDIIVTENMF 246 Query 316 GDYISDALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374 GD +SD + G +G+ P A+LS + + L+E HG+AP AGQ+ NP + ILSA MML Sbjct 247 GDILSDEASMLTGSLGMLPSASLSSSGLHLYEPVHGSAPDIAGQNIANPLAAILSAAMML 306 Query 375 R-YLGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVST 415 R G + A V ++ + + T D A+ G++ +T Sbjct 307 RTSFGLEAEAQAVEHAVDQVLRAGKRTKDLAK---GSEHCTT 345 >RecName: Full=Protein DlpA [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Sequence ID: Q48806.1 Length: 615 Range 1: 9 to 366 Score:113 bits(282), Expect:8e-26, Method:Compositional matrix adjust., Identities:107/408(26%), Positives:174/408(42%), Gaps:70/408(17%) Query 39 IPFIEGDGIGIDIA----PVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWL 94 I + GDGIGI++ PV + V+D V +Y I W E + E A + Sbjct 9 IAVLPGDGIGIEVTEATLPVFE-VLDVPVILNYG---DIGW-EFWKKEGAA--------I 55 Query 95 PDETLEAIKEYQVAIKGPLTTP--------VGGGIRSLN-------VALRQQLDLYVCLR 139 P T + I + G +T+ + ++ N + LRQ LDL+ +R Sbjct 56 PSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVR 115 Query 140 PVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIR 199 P P N I RENSE +Y G ++ P+A+ + L + I Sbjct 116 PCFSIDDQSKPF------NFCIIRENSEGLYCGFDY-FPLPKAIH--SLLAESQHWQTIP 166 Query 200 FPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVA 259 E A ++ SK G +RL A ++A+ VTL K N+++ G F +E Sbjct 167 ADE-ASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLR-ESGEFTRKIFEST 224 Query 260 VKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYI 319 + + PK I D +A ++ P ++ VI N+ GD + Sbjct 225 AQRY---------------PKIQADILNVDAVALWLIKS----PEKFGVIVAENMFGDIL 265 Query 320 SDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGW 379 SD A +GG+G+AP AN+ D FE HG+ P+ ++ NP ++ L+ M+L + G+ Sbjct 266 SDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGY 324 Query 380 KEAADLVVQGIEGAI-ESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + A +V + I E + +TYD +T+ A+I+H Sbjct 325 PDRAKKIVNAVMQVIKEKRFITYDL------GGHATTTDMANAVIEHC 366 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Mycobacterium tuberculosis H37Ra] Sequence ID: A5U706.1 Length: 336 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Mycobacterium tuberculosis CDC1551] Sequence ID: P9WKK8.1 Length: 336 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Mycobacterium tuberculosis H37Rv] Sequence ID: P9WKK9.1 Length: 336 Range 1: 3 to 332 Score:110 bits(274), Expect:9e-26, Method:Compositional matrix adjust., Identities:107/392(27%), Positives:168/392(42%), Gaps:70/392(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ V+DA V G +K + A + + LPD Sbjct 3 LAIIAGDGIGPEVTAEAVKVLDAVVP----GVQKTSY-----DLGARRFHATGEVLPDSV 53 Query 99 LEAIKEYQVAIKGPL---TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 + ++ + + G + + P G R L + LR +LD ++ LRP R + GV SP+ Sbjct 54 VAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNP 113 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 ++ V+ RE +E Y G G V N + E+ V G++ V + Sbjct 114 GIDFVVVREGTEGPYTG----NGGAIRVGTPNEVATEVSVNT-------AFGVRRVVADA 162 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW-- 273 R RR R +TLVHK N++ F GG W Sbjct 163 FERARRR---------RKHLTLVHKTNVLTFA----------------------GGLWLR 191 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 V E + + + DA ++ P + VI T NL GD I+D AA GGIG+A Sbjct 192 TVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLA 251 Query 334 PGANLSDTVG---LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGI 390 N+ T +FE HG+AP AGQ +P + I+S ++L +LG +AA V + + Sbjct 252 ASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAV 311 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 E + ++ G++ ++TS G+ I Sbjct 312 EAHLATR-----------GSERLATSDVGERI 332 >RecName: Full=Tartrate dehydrogenase/decarboxylase; Short=TDH; AltName: Full=D-malate dehydrogenase [decarboxylating] [Pseudomonas putida] Sequence ID: Q51945.3 Length: 365 Range 1: 8 to 357 Score:109 bits(273), Expect:2e-25, Method:Compositional matrix adjust., Identities:113/401(28%), Positives:173/401(43%), Gaps:68/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKR--KIEWMEIYAGEKATKVYGKDNWLPD 96 I I GDGIG+++ P V++AA K EW A +GK +PD Sbjct 8 IAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEW----ASCDYYLQHGK--MMPD 61 Query 97 ETLEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 + E +K+Y A+ P P + + R++ D YV +RPVR F GVP + Sbjct 62 DWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALA 121 Query 153 TPE--KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKP 210 + ++ V+ REN+E Y+ + + +NE+ +++ F Sbjct 122 NRKVGDIDFVVVRENTEGEYSSL--------GGIMFENTENEIVIQESIF---------- 163 Query 211 VSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDG 270 ++ G R+++ A A +R VT K N M + + D E + D Sbjct 164 -TRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAISM-PYWDKRTEAMAAHYPHVSWD- 220 Query 271 GPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATL-NLNGDYISDALAAEVGG 329 Q I D + +L+P + V+ NL GD +SD A G Sbjct 221 -----------KQHI-------DILCARFVLQPERFDVVVVASNLFGDILSDLGPACAGT 262 Query 330 IGIAPGANLS---DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG-----WKE 381 IGIAP ANL+ + LFE HG+AP G++ NP ++I S +ML +LG ++ Sbjct 263 IGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIWSGALMLEFLGQGDERYQR 322 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 A D ++ IE I +VT D M G +ST Q G AI Sbjct 323 AHDDMLNAIERVIADGSVTPD----MGGT--LSTQQVGAAI 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2] Sequence ID: A1KMY9.1 Length: 336 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172] Sequence ID: C1AGB0.1 Length: 336 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Mycobacterium tuberculosis variant bovis AF2122/97] Sequence ID: P94929.1 Length: 336 Range 1: 3 to 332 Score:108 bits(269), Expect:5e-25, Method:Compositional matrix adjust., Identities:107/392(27%), Positives:168/392(42%), Gaps:70/392(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ V+DA V G +K + A + + LPD Sbjct 3 LAIIAGDGIGPEVTAEAVKVLDAVVP----GVQKTSY-----DLGARRFHATGEVLPDSV 53 Query 99 LEAIKEYQVAIKGPL---TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 + ++ + + G + + P G R L + LR +LD ++ LRP R + GV SP+ Sbjct 54 VAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNP 113 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 ++ V+ RE +E Y G G V N + E+ V G++ V + Sbjct 114 GIDFVVVREGTEGPYTG----NGGAIRVGTPNEVATEVSVNT-------AFGVRRVVADA 162 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW-- 273 R RR R +TLVHK N++ L GG W Sbjct 163 FERARRR---------RKHLTLVHKTNVLT----------------------LAGGLWLR 191 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 V E + + + DA ++ P + VI T NL GD I+D AA GGIG+A Sbjct 192 TVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLA 251 Query 334 PGANLSDTVG---LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGI 390 N+ T +FE HG+AP AGQ +P + I+S ++L +LG +AA V + + Sbjct 252 ASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAV 311 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 E + ++ G++ ++TS G+ I Sbjct 312 EAHLATR-----------GSERLATSDVGERI 332 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Desulfitobacterium hafniense Y51] Sequence ID: Q24XT2.1 Length: 352 Range 1: 2 to 349 Score:107 bits(267), Expect:1e-24, Method:Compositional matrix adjust., Identities:112/407(28%), Positives:190/407(46%), Gaps:79/407(19%) Query 37 PIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPD 96 P I + GDGIG +I P V+ A + ++ A + E+ + G A ++ GK LPD Sbjct 2 PKIAVLPGDGIGQEIIPQAVRVLKAVLAETDA---EFEFQDYPIGGAAIELVGK--ALPD 56 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGI-----------RSLNVALRQQLDLYVCLRPVRYFT 145 ETL+ +E + G VGG + + LR+ L+ Y +RPVR Sbjct 57 ETLQGCREADAVLLGA----VGGHQWDHLPASERPETAALLGLRKGLNFYANIRPVRM-- 110 Query 146 GVPSPVKTP-------EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKI 198 +PS + T + V+MV+ RE + +Y G + + +P + K+ Sbjct 111 -IPSLLATSTLKENVLDGVDMVVIRELTGGVYFGEKGRSDNPRS-----------AYDKM 158 Query 199 RFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEV 258 + S+E R++ + + A+ + + V K N+++ T +++ E+ Sbjct 159 TY-----------SEEEIRRILIQGFETAMLRSKKLCS-VDKANVLE-TSRLWREIANEL 205 Query 259 AVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDY 318 A KE+ ++ + + D Q++ P ++ VI T N+ GD Sbjct 206 A-KEY-------------------PEVELTHMYVDNAAMQLVRNPKQFDVIVTENMFGDI 245 Query 319 ISDALAAEVGG-IGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYL 377 ++D LA+ +GG IG+ A+LS T G++E HG+AP AG++ NP + ILSA +MLRY Sbjct 246 LTD-LASMLGGSIGMLSSASLSGTQGMYEPAHGSAPDIAGKNLANPLATILSAALMLRYS 304 Query 378 GWKEAADLVVQ-GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 EA L ++ +E +E T D A+ G K V T + G A++ Sbjct 305 FGMEAEALRIESAVEKVLEQGYRTGDLAQ--AGDKVVGTIEMGDAVL 349 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Symbiobacterium thermophilum IAM 14863] Sequence ID: Q67JY2.1 Length: 368 Range 1: 8 to 367 Score:106 bits(264), Expect:4e-24, Method:Compositional matrix adjust., Identities:110/409(27%), Positives:176/409(43%), Gaps:70/409(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+ AA + A ++E+ E G A G PDET Sbjct 8 IACLPGDGIGPEVTRGAVTVLQAA---AAAYGFRLEFSEYLVGGAAYDAVGTP--FPDET 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI------RSLNVALRQQLDLYVCLRPVRYFTGV--PSP 150 +A + G + P G+ + +A+R++ DLY LRP+ + + SP Sbjct 63 RDACDRADAILFGAVGGPRYEGLPWDLRPEAGLLAIRKRYDLYANLRPILLYPPLKDASP 122 Query 151 VKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 +K V+ +I RE IY G P ++ + G ++ G+ Sbjct 123 LKNEIIGGGVDFIIVRELVGGIYFG------EPRGIETL-----PDGTRR-------GVN 164 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEV--AVKEFGA 265 + + +R+ R + A R +T V KGN+M+ A K W V +EF Sbjct 165 TEVYTDAEIARIARMGFEIA-RGRRRRLTSVDKGNVME----AGKLWRTVVDEVAREF-- 217 Query 266 KPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 + ++ ++AD QIL RP ++ V+ NL GD++SD A Sbjct 218 -----------------PDVEVEHLLADNAAMQILRRPGDFDVMLASNLFGDFLSDEAAM 260 Query 326 EVGGIGIAPGANLSDTV-------GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-L 377 G IG+ P A+L G +E HG+AP AGQD+ NP + IL M+LR+ L Sbjct 261 LTGSIGLLPSASLGAARNRFGLPKGFYEPIHGSAPDIAGQDRANPLAAILCGAMLLRHSL 320 Query 378 GWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 G ++AA V Q + +E T D + G + T+ +A+ + Sbjct 321 GREDAARAVEQAVAAVLEEGLRTADIT--VPGTAVLGTAAMARAVADRV 367 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Streptococcus pneumoniae R6] Sequence ID: Q8DPJ4.1 Length: 345 Range 1: 10 to 345 Score:105 bits(262), Expect:4e-24, Method:Compositional matrix adjust., Identities:116/397(29%), Positives:182/397(45%), Gaps:75/397(18%) Query 44 GDGIGIDIAPVMKNVVDAAVEKS---YAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLE 100 GDGIG +I V++A EK+ Y R+ + G + LPDETL+ Sbjct 10 GDGIGPEIMEAGLEVLEALAEKTGFDYEIDRRP-----FGG---ADIDAAGPPLPDETLK 61 Query 101 AIKEYQ----VAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVP--SPVKTP 154 A +E VAI P V +ALR++L+LY +RPV+ F + SP+K P Sbjct 62 ASREADAILLVAIGSPQYDGVAVRPEQGLMALRKELNLYANIRPVKIFDSLKYLSPLK-P 120 Query 155 EK---VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPV 211 E+ V+ V+ RE + +IY G + + E +K R I Sbjct 121 ERISGVDFVVVRELTGEIYFG--------------DHILEE---RKAR-------DINDY 156 Query 212 SKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 S E R++R+A + A N R VT + K N++ T ++ EVA ++F Sbjct 157 SYEEVERIIRKAFEIA-RNRRKIVTSIDKQNVLA-TSKLWRKVAEEVA-QDF-------- 205 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 +T++ + D+ ++ PA++ VI T NL GD +SD + G +G Sbjct 206 -----------PDVTLEHQLVDSAAMLMITNPAKFDVIVTENLFGDILSDESSVLSGTLG 254 Query 332 IAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR-YLGWKEAADLVVQG 389 + P A+ S+ L+E HG+AP AGQ NP S+ILS MMLR G E + + + Sbjct 255 VMPSASHSENGPSLYEPIHGSAPDIAGQGIANPISMILSVVMMLRDSFGRYEDTERIKRA 314 Query 390 IEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +E ++ + +T D + ST + +AII + Sbjct 315 VETSLAAGILTRDI------GGQASTKEMMEAIIARL 345 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Aquifex aeolicus VF5] Sequence ID: O66607.1 Length: 364 Range 1: 6 to 356 Score:105 bits(262), Expect:7e-24, Method:Compositional matrix adjust., Identities:104/405(26%), Positives:173/405(42%), Gaps:71/405(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I ++GDGIG +I V+D E + E+ E G +A G + LP+ET Sbjct 6 IAVLKGDGIGPEIVEQALRVLDKIGEIYGV---EFEYREGLIGGEAIDKTG--DPLPEET 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN------VALRQQLDLYVCLRPVRYFTGVPSPVK 152 L+ KE + G + P + + + +R++LDLY LRP + + + S Sbjct 61 LKICKESDAILLGAVGGPKWDNLPTDKRPEKGLLRIRKELDLYANLRPAKVWDALISSSP 120 Query 153 TPEKV----NMVIFRENSEDIY----AGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETA 204 E+V +M++ RE + IY GI G A+ + + ++E+ Sbjct 121 LKEEVVKGTDMIVIRELTSGIYYGEPRGIFEENGKRYAINTMKYTEDEI----------- 169 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 R+VR+ + A R +T V K N+++ + Sbjct 170 ------------RRIVRKGFEIA-RKRRKKLTSVDKANVLEVS----------------- 199 Query 265 AKPLDGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 W V E + + ++ + D Q++ RP + VI T N+ GD +SD Sbjct 200 ------ALWRQIVEEEKENYPDVELEHLYIDNCAMQLVRRPTSFDVIVTGNIFGDILSDE 253 Query 323 LAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKE 381 VG +G+ P A++ D L+E HG+AP AG+ NP + ILSA MML+Y + Sbjct 254 AGVVVGSLGMLPSASIGDRYALYEPVHGSAPDIAGKGIANPIATILSAAMMLKYSFNMDK 313 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 A DL+ + IE + T D G +V T + I++++ Sbjct 314 AHDLIEKAIEETLNQGYRTPDI--YSEGCIKVGTKEITDKILENL 356 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Acidithiobacillus ferrooxidans] Sequence ID: Q56268.1 Length: 358 Range 1: 4 to 354 Score:104 bits(260), Expect:1e-23, Method:Compositional matrix adjust., Identities:109/405(27%), Positives:175/405(43%), Gaps:71/405(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I GDGIG +I + V+DA + ++ G R E + A A+ D+ LP + Sbjct 4 IAIFAGDGIGPEIVAAARQVLDAVDQAAHLGLRCTEGLVGGAALDAS-----DDPLPAAS 58 Query 99 LEAIKEYQVAIKG-----------PLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGV 147 L+ I G P P G +R LR+ LDLY LRP + F + Sbjct 59 LQLAMAADAVILGAVGGPRWDAYPPAKRPEQGLLR-----LRKGLDLYANLRPAQIFPQL 113 Query 148 --PSPVKTPE---KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPE 202 SP++ PE V++++ RE + DIY G P +++I+ G ++ Sbjct 114 LDASPLR-PELVRDVDILVVRELTGDIYFG------QPRGLEVID------GKRR----- 155 Query 203 TAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 G ++ R+ A + A R + V K N+++ T + W EV Sbjct 156 --GFNTMVYDEDEIRRIAHVAFRAA-QGRRKQLCSVDKANVLETT----RLW-REV---- 203 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 V E + + + + D Q++ PA++ V+ T N+ GD +SD Sbjct 204 ------------VTEVARDYPDVRLSHMYVDNAAMQLIRAPAQFDVLLTGNMFGDILSDE 251 Query 323 LAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKE 381 + G IG+ P A+L + ++E HG+AP AGQDK NP + ILS MMLR+ L + Sbjct 252 ASQLTGSIGMLPSASLGEGRAMYEPIHGSAPDIAGQDKANPLATILSVAMMLRHSLNAEP 311 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 A V ++ ++ T D A G + T G A++ + Sbjct 312 WAQRVEAAVQRVLDQGLRTADIA--APGTPVIGTKAMGAAVVNAL 354 >RecName: Full=Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit gamma 2; AltName: Full=NAD(+)-specific ICDH subunit gamma 2; Flags: Precursor [Rattus norvegicus] Sequence ID: Q4QQT5.1 Length: 395 Range 1: 54 to 359 Score:105 bits(261), Expect:1e-23, Method:Compositional matrix adjust., Identities:94/369(25%), Positives:165/369(44%), Gaps:70/369(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ +K + + +E+ E++A +++ + Sbjct 54 VTMIPGDGIGPELMVHVKRIFRSNCVP-------VEFEEVWATSTSSE------EEINNA 100 Query 99 LEAIKEYQVAIKGPLTT--PVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEK 156 L AI+ ++ +KG + T + +S N R LDLY + + F GV + K Sbjct 101 LMAIRRNRITLKGNIATNHHLPAKYKSHNTKFRTALDLYASVVHFKTFPGVETRHK---D 157 Query 157 VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 +++++ REN+E Y +E E+V+ GV + +K V+K + Sbjct 158 IDILVVRENTEGEYTNLEH-----ESVR---------GVVE---------SLKIVTKTKS 194 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+ A + A R VT+VHK NIMK +G F +VA Sbjct 195 VRIADYAFRLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHY-------------- 240 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 +IT++ +I D Q++ +P ++ V+ NL G+ I+ VGG GI PGA Sbjct 241 ------PQITLESMIIDNTAMQLVSKPQQFDVMLMPNLYGNIINSVCTGLVGGSGIVPGA 294 Query 337 NLSDTVGLFEATHGTAPKYAGQDK-----VNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 N D+ +FE T K GQD NP +++L++ +ML YL + A + + Sbjct 295 NYGDSYAIFE----TGSKEIGQDLAHRNIANPVAMLLTSCIMLDYLDLQLYAAHIRSAVM 350 Query 392 GAIESKTVT 400 ++++K++ Sbjct 351 ASLQNKSIC 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Priestia megaterium DSM 319] Sequence ID: P41019.2 Length: 369 Range 1: 5 to 336 Score:104 bits(259), Expect:2e-23, Method:Compositional matrix adjust., Identities:102/382(27%), Positives:171/382(44%), Gaps:66/382(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDG+G ++ V+ A E+ + E+ G A G LP+ T Sbjct 5 VAVLPGDGVGTEVTKGAVAVLKAIGERF---DHQFEFTYGLIGGAAIDEAG--TPLPEST 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----------VALRQQLDLYVCLRPVRYFTGVP 148 +E K+ + G VGG N +A+R++LDLY LRPV ++ + Sbjct 60 IETCKQADAVLLGS----VGGPKWDRNPSHLRPEKGLLAIRKELDLYANLRPVTFYDSLA 115 Query 149 --SPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETA 204 SP+K E V+ +I RE + +Y G P + E V + + T Sbjct 116 DASPLKKEYIEGVDFIIVRELTGGLYFG------KPSERRTEG--NKETVVDTLFYKRTE 167 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 R++R+A A+ N R VT V K N+++ + +++ EVA Sbjct 168 -----------IERIIRQAFDTAV-NRRKKVTSVDKANVLESSR-VWREVAEEVA----- 209 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 K + ++ ++ D+ Q++ P + V+ T N+ GD +SD + Sbjct 210 ---------------KDYPDVELEHMLVDSAAMQLIRNPKYFDVVVTENMFGDILSDEAS 254 Query 325 AEVGGIGIAPGANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G +G+ P A+L+ D L+E HG+AP AGQ+K NP + ILSA M+LR+ G ++ Sbjct 255 MLTGSLGMLPSASLTADGPSLYEPVHGSAPDIAGQNKANPIAAILSAAMLLRHSFGLEKE 314 Query 383 ADLVVQGIEGAIESKTVTYDFA 404 A ++ Q +E + + T D A Sbjct 315 AAVIEQAVESVLHAGHRTADLA 336 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Chlorobaculum tepidum TLS] Sequence ID: P59028.1 Length: 352 Range 1: 8 to 352 Score:103 bits(257), Expect:2e-23, Method:Compositional matrix adjust., Identities:111/403(28%), Positives:170/403(42%), Gaps:76/403(18%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ +V++A V K + + +E E G + V+G + L DETLEA Sbjct 8 IPGDGIGPEVVAGALDVLNA-VAKKHGFEVSVE--EHLFGGASYDVHG--SMLTDETLEA 62 Query 102 IKEYQVAIKGPLTTPVGGGIRSLNV-----------ALRQQLDLYVCLRPVRYFTGV--P 148 K + G + GG + N+ +R++L L+ LRP R + + Sbjct 63 CKNCDAVLLGAV-----GGYKWENLPHDKKPEAALLKIRKELGLFANLRPARVYDALVAS 117 Query 149 SPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 S +KT + + ++FRE + IY G P G + ET G Sbjct 118 STLKTEVVQGTDFMVFRELTGGIYFG--QPRG---------------------YDETRGW 154 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + R+ R A +YA VT + K N+++ V +F Sbjct 155 NTMVYERYEVERIARLAFEYAQKRGNAKVTSIDKANVLE--------------VSQF--- 197 Query 267 PLDGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 W V E + +I + D+ D Q++ P ++ VI T NL GD +SD Sbjct 198 ------WRNIVHEVHQDFPEIELVDMYVDNAAMQVVRNPKQFEVIVTSNLFGDILSDISG 251 Query 325 AEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMML-RYLGWKEAA 383 G +G+ P A++ L+E HG+AP AGQ+K NP + I S MM E A Sbjct 252 MITGSLGMLPSASIGSEHALYEPIHGSAPDIAGQNKANPIATIASVAMMFENSFNRPEVA 311 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + IEGA+ + T D A G ST++ AI+ I Sbjct 312 ADIYAAIEGALAAGFRTGDIA--AAGEAISSTTEMTAAIVARI 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Geobacillus kaustophilus HTA426] Sequence ID: Q5KWJ4.1 Length: 371 Range 1: 6 to 358 Score:103 bits(257), Expect:3e-23, Method:Compositional matrix adjust., Identities:117/407(29%), Positives:177/407(43%), Gaps:72/407(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVE--KSYAGKRKIEWMEIYAGEKATKVYGKDNWLPD 96 I + GDGIG K V AVE K+ + E+ Y + LP+ Sbjct 6 IAVLPGDGIG-------KEVTSGAVEVLKAVGIRFGHEFTFEYGLIGGAAIDEAGTPLPE 58 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLN----------VALRQQLDLYVCLRPVRYFTG 146 ETL +E + G VGG N +A+R+QLDLY LRPV + Sbjct 59 ETLRLCRESDAVLLGA----VGGPKWDDNPPHLRPEKGLLAIRKQLDLYANLRPVVCYDS 114 Query 147 V--PSPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPE 202 + SP+K + V+ VI RE + IY G P+G + + E Sbjct 115 LVSASPLKPDLVQGVDFVIVRELTGGIYFG--QPSG-----------------RVVENGE 155 Query 203 TAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 + KE R+VR A A + VT V K N++ + +++ EVA K+ Sbjct 156 EKAVDTLLYKKEEIERIVRMAFILA-RGRKKKVTSVDKANVLSSSR-LWREVAEEVA-KQ 212 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 F +T++ ++ D Q++ P ++ VI T N+ GD +SD Sbjct 213 F-------------------PDVTLEHMLVDNAAMQLIRAPKQFDVIVTENMFGDILSDE 253 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWK 380 + G +G+ P A+LS + L+E HG+AP AG +K NP + ILSA MMLR G Sbjct 254 ASMLSGSLGMLPSASLSASGPSLYEPVHGSAPDIAGMNKANPIAAILSAAMMLRLSFGLT 313 Query 381 EAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 A+ V + A++ T D A +G + VST++ + I +L Sbjct 314 AEAEAVEHAVRQALDQGLRTADLAP--SGGRIVSTNEMVEEIKTAVL 358 >RecName: Full=Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; AltName: Full=Isocitric dehydrogenase subunit gamma 2; AltName: Full=NAD(+)-specific ICDH subunit gamma 2; Flags: Precursor [Mus musculus] Sequence ID: Q8BPC6.1 Length: 396 Range 1: 51 to 359 Score:103 bits(258), Expect:3e-23, Method:Compositional matrix adjust., Identities:92/368(25%), Positives:162/368(44%), Gaps:62/368(16%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLP 95 R + I GDGIG ++ +K + + +++ E++ + + Sbjct 51 RHTVAMIPGDGIGPELMVHVKKIFRSNCVP-------VDFEEVWVTSTS------NEEEI 97 Query 96 DETLEAIKEYQVAIKGPLTTP--VGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKT 153 + L AI+ +VA+KG + T + +S N R LDLY V +F P + Sbjct 98 NNALMAIRRNRVALKGNIATNHNLPARYKSHNTKFRTILDLYA---SVVHFKTFPGVMTR 154 Query 154 PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSK 213 + +++++ REN+E Y +E E+VK GV + +K V+K Sbjct 155 HKDIDILVVRENTEGEYTNLEH-----ESVK---------GVVE---------SLKIVTK 191 Query 214 EGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW 273 + R+ A + A R VT+VHK NIMK +G F +VA Sbjct 192 TKSVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHY----------- 240 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 +IT++ +I D Q++ +P ++ V+ NL G+ I+ VGG GI Sbjct 241 ---------PQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGIV 291 Query 334 PGANLSDTVGLFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIEG 392 PGAN D+ +FE + A ++ NP +++L++ +ML YL + A + + Sbjct 292 PGANYGDSYAIFEMGSKEIGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMA 351 Query 393 AIESKTVT 400 ++++K V Sbjct 352 SLQNKAVC 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P05645.3 Length: 365 Range 1: 5 to 346 Score:102 bits(255), Expect:5e-23, Method:Compositional matrix adjust., Identities:109/398(27%), Positives:180/398(45%), Gaps:75/398(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG + V+++ D V KS A + E+ Y + N LP+ET Sbjct 5 IALLPGDGIGPE---VLESATD--VLKSVAERFNHEFEFEYGLIGGAAIDEHHNPLPEET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP--SP 150 + A K A+ GP +R +++R+QLDL+ LRPV+ F + SP Sbjct 60 VAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLFANLRPVKVFESLSDASP 119 Query 151 VKTP--EKVNMVIFRENSEDIYAGIEWPA-------GSPEAVKLINFLQNEMGVKKIRFP 201 +K + V+ VI RE + +Y G P+ G EAV + + + E+ Sbjct 120 LKKEYIDNVDFVIVRELTGGLYFG--QPSKRYVNTEGEQEAVDTLFYKRTEI-------- 169 Query 202 ETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVK 261 R++R + A + VT V K N+++ + +++ +VA + Sbjct 170 ---------------ERVIREGFKMAAAR-KGKVTSVDKANVLE-SSRLWREVAEDVA-Q 211 Query 262 EFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISD 321 EF + ++ ++ D Q++ P ++ V+ T N+ GD +SD Sbjct 212 EF-------------------PDVKLEHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSD 252 Query 322 ALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR-YLGW 379 + G +G+ P A+LS + + LFE HG+AP AG+ NP + ILSA M+LR G Sbjct 253 EASMLTGSLGMLPSASLSSSGLHLFEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGL 312 Query 380 KEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQ 417 +E A V + + S T D AR ++E S++Q Sbjct 313 EEEAKAVEDAVNKVLASGKRTRDLAR----SEEFSSTQ 346 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Saccharopolyspora erythraea NRRL 2338] Sequence ID: A4FMQ2.1 Length: 347 Range 1: 3 to 300 Score:102 bits(254), Expect:5e-23, Method:Compositional matrix adjust., Identities:94/346(27%), Positives:150/346(43%), Gaps:54/346(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG ++ V+ V + + + A + + LP+ Sbjct 3 LAVIPGDGIGPEVVAEALKVLGEVVPDTEITRYDL---------GAARWHATGELLPESV 53 Query 99 LEAIKEYQVAIKGPL---TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 L ++++ + G + + P G R L + LR +LD +V LRP R + GV SPV P Sbjct 54 LGELRQHDAILLGAVGDPSVPSGILERGLLLRLRFELDHHVNLRPARLYPGVKSPVSDPG 113 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 +++MV+ RE +E YAG N ++K E A + + G Sbjct 114 EIDMVVVREGTEGPYAG------------------NGGLLRKDTTHEIA-TEVSINTAFG 154 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 R+VR A A R +TLVHK N++ + EV+++ Sbjct 155 VERVVRDAFARAASRPRKHLTLVHKTNVLTHAGSLWSRVVEEVSLQH------------- 201 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 +T+ DA ++ P+ + VI T NL GD I+D A GGIG+A Sbjct 202 -------PDVTVAYQHVDATTIHMVTDPSRFDVIVTDNLFGDIITDLAGAITGGIGLAAS 254 Query 336 ANLSDTV---GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG 378 N+ T +FE HG+AP AGQ +P + +LS ++L ++G Sbjct 255 GNIDATRRNPSMFEPVHGSAPDIAGQGTADPTAAVLSVALLLDHVG 300 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Carboxydothermus hydrogenoformans Z-2901] Sequence ID: Q3AEQ2.1 Length: 374 Range 1: 12 to 364 Score:102 bits(255), Expect:5e-23, Method:Compositional matrix adjust., Identities:113/409(28%), Positives:180/409(44%), Gaps:76/409(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I +K V V K+ K+ I + Y + + LP+ET Sbjct 12 ILVLPGDGIGPEI---IKEAV--KVLKALGEKKGITFNFQYGLIGGAAIDERGVPLPEET 66 Query 99 LEAIKEYQVAIKG-----------PLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGV 147 +E K+ + G P P GG+ + +R+ DLY LRPV +F + Sbjct 67 VELGKQCDAILLGAVGGPKWDNLPPEIRPELGGL----LKIRKVFDLYANLRPVMFFPEL 122 Query 148 --PSPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFP-- 201 SP+K E V++++ RE + +Y G +K RF Sbjct 123 KNASPLKPDIIEGVDILMVRELTGGLYFG-----------------------EKKRFTTE 159 Query 202 --ETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVA 259 E A I +++ R+VR + A R +TLV K N+++ + + W Sbjct 160 QGEQAVIDTLIYTEKEVERVVRLGFELA-QKRRGKLTLVDKANVLESS----RFW----- 209 Query 260 VKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYI 319 + + G E K + + + D Q++ P ++ VI T N+ GD + Sbjct 210 ------REITG------EIKKEYPDVELSYMYVDNCAMQLIRNPRQFDVIVTENMFGDIL 257 Query 320 SDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LG 378 +D + G IG+ P A+L+ GL+E HG+AP AGQ+K NP + ILSA MMLRY L Sbjct 258 TDEGSVLAGSIGLLPSASLNGKFGLYEPIHGSAPDIAGQNKANPLATILSAGMMLRYSLD 317 Query 379 WKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 E A L+ + ++ ++ T D L G V+ + G + + IL Sbjct 318 CPEEALLIEKAVKAVLQKGYRTGDI--LEPGTTLVTCEEMGDLVAEEIL 364 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Mycolicibacterium vanbaalenii PYR-1] Sequence ID: A1T6Z4.1 Length: 336 Range 1: 3 to 333 Score:102 bits(253), Expect:7e-23, Method:Compositional matrix adjust., Identities:106/395(27%), Positives:170/395(43%), Gaps:74/395(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKD-NWLPDE 97 + I GDGIG ++ V+DA + G K E+ + + Y K LPD Sbjct 3 LAVIAGDGIGPEVITEALKVLDAVLP----GVEKTEY------DLGARQYHKTGEVLPDS 52 Query 98 TLEAIKEYQVAIKGPL---TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 LE +K + + G + + P G R L + +R +LD ++ LRP R + GV SP+ Sbjct 53 VLEELKGHDAILLGAIGDPSVPSGLLERGLLLRIRFELDHHINLRPARLYPGVQSPLAGN 112 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 +++ V+ RE +E Y G G V + + E+ V Sbjct 113 PEIDFVVVREGTEGPYTG----NGGAIRVGTPHEIATEVSVN------------------ 150 Query 215 GTSRLVRRAIQYAI---DNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 T+ VRRA+Q A R +TLVHK N++ A W V ++ Sbjct 151 -TAFGVRRAVQDAFGRAQQRRKHLTLVHKNNVLT---NAGSLWWRTVQTVAAEYPDVEVA 206 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 HV DA ++ P + VI T NL GD I+D AA GGIG Sbjct 207 YQHV-----------------DAATIHMVTDPGRFDVIVTDNLFGDIITDLAAAVCGGIG 249 Query 332 IAPGANLSDTV---GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQ 388 +A N+ T+ +FE HG+AP AGQ +P + ++S ++L ++ +AA V + Sbjct 250 LAASGNIDATLTHPSMFEPVHGSAPDIAGQGIADPTAAVMSVSLLLAHMAEVDAAARVDK 309 Query 389 GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + + ++ G +++ST+ G+ I+ Sbjct 310 AVAEHLATR-----------GDEKLSTAAVGERIL 333 >RecName: Full=3-isopropylmalate dehydrogenase, chloroplastic; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase; Flags: Precursor [Brassica napus] Sequence ID: P29102.1 Length: 406 Range 1: 46 to 398 Score:102 bits(254), Expect:1e-22, Method:Compositional matrix adjust., Identities:116/407(29%), Positives:175/407(42%), Gaps:73/407(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ + KNV+ A S G + + E+ G A + G LP+ET Sbjct 46 ITLLPGDGIGPEVISIAKNVLQQA--GSLEG-LEFSFQEMPVGGAALDLVGVP--LPEET 100 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----------VALRQQLDLYVCLRPVRYFTGVP 148 + A KE + G +GG N + LR L ++ LRP T +P Sbjct 101 VSAAKESDAVLLGA----IGGYKWDKNEKHLKPETGLLQLRAGLKVFANLRPA---TVLP 153 Query 149 SPV-------KTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFP 201 V + E V++++ RE + IY G+ P +K NE G Sbjct 154 QLVDASTLKREVAEGVDLMVVRELTGGIYFGV------PRGIK-----TNENG------- 195 Query 202 ETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVK 261 E G + + R+ R A + A R + V K N++ A W V Sbjct 196 EEVGYNTEVYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD----ASILWRRRVTA- 249 Query 262 EFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISD 321 E P + + + D Q++ P ++ I T N+ GD +SD Sbjct 250 ------------LAAEYPD----VELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSD 293 Query 322 ALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGW 379 + G IG+ P A+LSD+ GLFE HG+AP AGQDK NP + ILSA M+L+Y LG Sbjct 294 EASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGE 353 Query 380 KEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++AA + + GA+ T D G K V + G+ ++K + Sbjct 354 EKAAKRIEDAVLGALNKGFRTGDI--YSAGTKLVGCKEMGEEVLKSV 398 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Frankia sp. EAN1pec] Sequence ID: A8L554.1 Length: 342 Range 1: 3 to 305 Score:100 bits(250), Expect:2e-22, Method:Compositional matrix adjust., Identities:105/353(30%), Positives:152/353(43%), Gaps:58/353(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG VV + A K+E + G + G+ LPD Sbjct 3 LAVIGGDGIG-------PEVVAEGLRVLRAVHPKVETTDYDLGARRWHETGE--TLPDSV 53 Query 99 LEAIKEYQVAIKGPLT---TPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 L ++ + + G + P G R L + LR +LD +V LRPVR + GV SP+ Sbjct 54 LAELRGHDAILLGAVGDPGVPSGVLERGLLLRLRFELDHHVNLRPVRLYPGVTSPLAGDP 113 Query 156 KVNMVIFRENSEDIYAGI--EWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSK 213 ++M++ RE +E YAG G+P+ V L GV+ Sbjct 114 AIDMIVVREGTEGPYAGAGGTLRRGTPQEVATEESLNTRFGVE----------------- 156 Query 214 EGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW 273 R+VR A A R +TLVHK N++ A W VA E GA Sbjct 157 ----RVVRDAFARASRRPRAHLTLVHKTNVLT---KAGDLWARTVA--EVGA-------- 199 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 E P +++ DA + PA + V+ T N+ GD ++D AA GGIG+A Sbjct 200 ---EFP----AVSVDYQHVDAASMFFVTDPARFDVVVTDNMFGDILTDIGAAITGGIGLA 252 Query 334 PGANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAA 383 NL + +FE HG+AP AGQ +P + + S M+L +LG + A Sbjct 253 ASGNLDPSGANPSMFEPVHGSAPDIAGQGLADPTATVASVAMLLDHLGHADEA 305 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Synechococcus sp. CC9902] Sequence ID: Q3AYS1.1 Length: 357 Range 1: 8 to 357 Score:100 bits(249), Expect:3e-22, Method:Compositional matrix adjust., Identities:105/399(26%), Positives:180/399(45%), Gaps:62/399(15%) Query 41 FIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLE 100 + GDGIG +I V + ++D ++ ++ + E G A G+ LP TL Sbjct 8 LLPGDGIGPEITAVARQLLDVVAQRH---GFQLMFEEQPIGGSAIDATGEP--LPASTLT 62 Query 101 AIKEYQVAIKGPLTTPVGGGI------RSLNVALRQQLDLYVCLRPVRYFTGV--PSPVK 152 A + + + +P + + + LR L+L+ LRPV+ + S +K Sbjct 63 ACRSADAVLLAAIGSPRFDSLPREKRPETGLLGLRSGLELFANLRPVKIVPALIGASSLK 122 Query 153 TP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKP 210 E V++++ RE + IY G P G EA +E G + + Sbjct 123 QEVIEGVDLMVVRELTGGIYFG--QPKGRIEADG------DERGFNTMTY---------- 164 Query 211 VSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDG 270 S R+ + A + A + + + + V K N++ ++ ++D +A Sbjct 165 -SASEVDRIAKVAFEIAGERN-NRLCSVDKANVLDVSQ-LWRDRVDAMA----------- 210 Query 271 GPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGI 330 P+ G+ + + + D Q++ P ++ V+ T NL GD +SD A G I Sbjct 211 --------PRYGE-VDVSHMYVDNAAMQLVRDPRQFDVLLTGNLFGDILSDEAAMLTGSI 261 Query 331 GIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE--AADLVV 387 G+ P A+L SD GLFE HG+AP AGQDK NP +++LSA MMLR +G K+ AAD + Sbjct 262 GMLPSASLGSDGPGLFEPVHGSAPDIAGQDKANPMAMVLSAAMMLR-IGLKQSSAADDLE 320 Query 388 QGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + S T D + G + G+ ++K + Sbjct 321 RAVDAVLASGFRTGDL--MSEGCTPLGCQAMGEQLLKAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Salinibacter ruber DSM 13855] Sequence ID: Q2S0M8.2 Length: 365 Range 1: 9 to 350 Score:100 bits(249), Expect:3e-22, Method:Compositional matrix adjust., Identities:117/395(30%), Positives:179/395(45%), Gaps:64/395(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I ++ GDGIG ++ V++A A + E G A G LPD T Sbjct 9 IAWLPGDGIGPEVTREALRVLEAV---GSAHGFSVTATEHRMGGVALDETGMP--LPDST 63 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIR--SLNVALRQQLDLYVCLRPVRYFTGVP--SP 150 +A E A+ GP G R S +ALR+ L +Y LRPVR + SP Sbjct 64 RDACLESDAVLLGAVGGPKWADNTGDQRPESGLLALRKALGVYANLRPVRVPAALADASP 123 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 ++ P++V +++ RE + IY G +PE + + G + Sbjct 124 LR-PDRVGGTDILFVRELTGGIYFG------TPEG-------RTDDGARST--------- 160 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S + R+ A Q A D +VT V K N+++ +E W +E + Sbjct 161 -MAYSDDEIERIAHVAFQRARRRD-GNVTSVDKANVLEVSEL----W------REVVTEV 208 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 D P +T++ + D Q++ P ++ V+ T NL GD +SD AA Sbjct 209 HDDCP-----------DVTLRHLYVDNAAMQVVRDPRQFDVVLTGNLFGDILSDLAAALP 257 Query 328 GGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVV 387 G +G+ P A++ TVGLFE HG+AP AGQD NP + ILSA ++L +G AAD V Sbjct 258 GSLGLLPSASVGGTVGLFEPVHGSAPDIAGQDVANPTAAILSAALLLDEVGETAAADAVR 317 Query 388 QGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 G++ A+++ T D A ++ STS FG+ + Sbjct 318 HGVDAALDAGFRTADLA--ADNEEDASTSAFGREV 350 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Moorella thermoacetica ATCC 39073] Sequence ID: Q2RGA0.1 Length: 357 Range 1: 4 to 305 Score:100 bits(248), Expect:4e-22, Method:Compositional matrix adjust., Identities:99/349(28%), Positives:152/349(43%), Gaps:58/349(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I P V++A + + ++ E G A G LP ET Sbjct 4 IAVLPGDGIGPEIVPEAVKVLEAVSRRVGI---EFQFTEALVGGAAIDARGI--ALPPET 58 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVAL---RQQLDLYVCLRPVRYFTGV--PS 149 LE ++ A+ GP + R AL R++L LY LRP + + S Sbjct 59 LELCRQSDAVLLGAVGGPKWDTLPPAERPETAALLPLRKELGLYANLRPAFLYDSLVEAS 118 Query 150 PVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 P+K +++I RE + +Y G A K + EM + + Sbjct 119 PLKKEIVTGTDLIIVRELTGGLYFG---------AKKREQTAEGEMAYDTMYY------- 162 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 ++ R+VR A A R +T V K N++ T ++D ++ G P Sbjct 163 ----TRAEIERIVRLAFTIA-RQRRCHLTSVDKANVLT-TSRLWRDTVEDIK----GEFP 212 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 ++T++ + D Q++ RPA++ VI T N GD +SD + Sbjct 213 ----------------EVTVEHMYVDNCAMQLVRRPAQFDVIVTENTFGDILSDQASVLT 256 Query 328 GGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 G IG+ P A++ V L+E HG+AP AGQ K NP + ILSA MML+Y Sbjct 257 GSIGMLPSASIGGAVALYEPCHGSAPDIAGQQKANPLATILSAAMMLKY 305 >RecName: Full=3-isopropylmalate dehydrogenase 2, chloroplastic; Short=3-IPM-DH 2; Short=AtIMDH2; Short=AtIMDH3; Short=IMDH 2; AltName: Full=Beta-IPM dehydrogenase 2; AltName: Full=Isopropylmalate dehydrogenase 2; Short=AtIMD2; Flags: Precursor [Arabidopsis thaliana] Sequence ID: P93832.1 Length: 405 Range 1: 42 to 397 Score:100 bits(249), Expect:5e-22, Method:Compositional matrix adjust., Identities:115/411(28%), Positives:177/411(43%), Gaps:75/411(18%) Query 36 RPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLP 95 R I + GDGIG ++ + KNV+ A S G + + E+ G A + G LP Sbjct 42 RYTITLLPGDGIGPEVVSIAKNVLQQA--GSLEGV-EFNFREMPIGGAALDLVGVP--LP 96 Query 96 DETLEAIKEYQVAIKGPLTTPVGGGIRSLN-----------VALRQQLDLYVCLRPVRYF 144 +ET+ A KE + G + GG + N + +R L ++ LRP Sbjct 97 EETISAAKESDAVLLGAI-----GGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPA--- 148 Query 145 TGVPSPV-------KTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKK 197 T +P V + E V++++ RE + IY G P +K NE G Sbjct 149 TVLPQLVDASTLKREVAEGVDLMVVRELTGGIYFG------EPRGIK-----TNENG--- 194 Query 198 IRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYE 257 E G + + R+ R A + A R + V K N+++ A W Sbjct 195 ----EEVGFNTEVYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLE----ASILWRKR 245 Query 258 VAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGD 317 V E P + + + D Q++ P ++ I T N+ GD Sbjct 246 VTA-------------LASEYPD----VELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGD 288 Query 318 YISDALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 +SD + G IG+ P A+LSD+ GLFE HG+AP AGQDK NP + ILSA M+L+Y Sbjct 289 ILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKY 348 Query 377 -LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 LG ++AA + + A+ + T D G K V + G+ ++K + Sbjct 349 GLGEEKAAKRIEDAVLVALNNGFRTGDI--YSAGTKLVGCKEMGEEVLKSV 397 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Rhodococcus opacus B4] Sequence ID: C1B2M3.1 Length: 336 Range 1: 3 to 332 Score:99.0 bits(245), Expect:8e-22, Method:Compositional matrix adjust., Identities:109/391(28%), Positives:164/391(41%), Gaps:68/391(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG+++ V+ V +E E G + G+ LPD Sbjct 3 LAVIPGDGIGVEVTAEALKVLRKLVPD-------LETTEYDLGARRYNATGE--LLPDAD 53 Query 99 LEAIKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 L AI+E+ + G + P V G+ R L + +R LD +V LRP + + G SP+ Sbjct 54 LAAIREHDAILLGAIGDPSVTPGVLERGLLLNMRFALDHHVNLRPSQLYPGSKSPLAAQP 113 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 ++ V+ RE +E Y G G ++ P + + G Sbjct 114 DIDFVVVREGTEGPYTG-------------------NGGAIRVGTPHEIATEVSINTWFG 154 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 R+VR A A R VTL+HK N++ GA E E+ ++ H+ Sbjct 155 AERVVRYAFALA-QTRRKHVTLIHKTNVLS-NAGAIWTRAVETVSAEY--PDVETAYCHI 210 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 DA ++ P+ + VI T NL GD I+D A GGIG+A Sbjct 211 -----------------DAATIYMVTDPSRFDVIVTDNLFGDIITDLAGAVTGGIGLAAS 253 Query 336 ANLSDTVG----LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 N+ D G +FE HG+AP AGQ +P + ILSA ++LR+LG A + +E Sbjct 254 GNI-DASGTNPSMFEPVHGSAPDIAGQGIADPTAAILSAALLLRHLGRDGDAARIETAVE 312 Query 392 GAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 + S+ G +V TS+ G I Sbjct 313 ADLASR-----------GDSKVVTSEVGDRI 332 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Oceanobacillus iheyensis HTE831] Sequence ID: Q8EN68.1 Length: 366 Range 1: 5 to 352 Score:98.6 bits(244), Expect:1e-21, Method:Compositional matrix adjust., Identities:105/404(26%), Positives:177/404(43%), Gaps:72/404(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I K V+ A+ Y + + E G A YG LPD+T Sbjct 5 IILLPGDGIGREIIDSAKQVL-TAIASEY--NHRFTFEEHAIGGSAIDEYG--TPLPDKT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----------VALRQQLDLYVCLRPVRYFTGV- 147 ++A + + G VGG N + +R+QL L+ LRPV+ + + Sbjct 60 VDACSKADAILLGA----VGGPKWDANPSHLRPEKGLLGIRKQLGLFANLRPVKTISSLL 115 Query 148 -PSPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETA 204 SP+K + +M+I RE + IY G + V + + Sbjct 116 YASPLKEEIVSQADMLIIRELTGGIYFGTPSERTTNGVVDTLQY---------------- 159 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 S+E R+V R + A + +T V K N+++ + K W +E Sbjct 160 -------SREEIERIVERGFEAARIRKK-HLTSVDKANVLESS----KLW------REI- 200 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 V E K + + ++ DA +++ +P+ + VI T NL GD +SD + Sbjct 201 ----------VEEKSKDYPDVAVNHLLVDAAAMKLVTQPSFFDVIVTENLFGDILSDEAS 250 Query 325 AEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G +G+ P A+L +D +GL+E HG+AP AG+ NP ++ILSA +ML + G + Sbjct 251 VLTGSLGMLPSASLRADGLGLYEPVHGSAPDIAGKGIANPLAMILSAALMLEHSFGLVDE 310 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 A + + + + T D + G +V T Q A+++++ Sbjct 311 AKEIERAVNDCLLQGFHTADIH--IPGGVQVGTKQMTDAVLENV 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Halalkalibacterium halodurans C-125] Sequence ID: Q9K8E9.1 Length: 363 Range 1: 5 to 356 Score:98.6 bits(244), Expect:2e-21, Method:Compositional matrix adjust., Identities:105/404(26%), Positives:180/404(44%), Gaps:68/404(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+ A ++ + + G A G LP+ET Sbjct 5 IAVLPGDGIGPEVTDAAIEVLQAVADRF---GHTFSYKKALLGGCAIDEVG--TPLPEET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP--SP 150 L+ + A+ GP + G +R + LR+ L+L+ LRPV + + S Sbjct 60 LDVCRHADGILLGAVGGPKWDTLPGHLRPEKGLLGLRKGLNLFANLRPVTVYDSLADAST 119 Query 151 VKTP--EKVNMVIFRENSEDIYAG----IEWPAGSPEAVKLINFLQNEMGVKKIRFPETA 204 +K + V+++I RE + +Y G + E V + + + EM Sbjct 120 LKNDVIDGVDLLIVRELTGGLYFGEPRERRGEGETEEVVDTLLYTRGEM----------- 168 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 R++R+A + A+ ++ VT V K N+++ + +++ EVA +EF Sbjct 169 ------------RRIIRKAFELAMVRNK-HVTSVDKANVLESSR-MWREVANEVA-QEF- 212 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 ++T++ ++ D Q++ RP ++ V+ T NL GD +SD + Sbjct 213 ------------------PEVTLEHMLVDNAAMQLIRRPKQFDVLVTENLFGDILSDEAS 254 Query 325 AEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G +G+ P A+L SD GL+E HG+AP AG+ NP + I S MML+Y G E Sbjct 255 MVTGSLGMLPSASLTSDGPGLYEPIHGSAPDIAGKGVANPLATIASCAMMLKYSFGLHEE 314 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 A + IE ++ T D A+ G + ST A+++ I Sbjct 315 AKTIEDAIEAVLKQGYRTADIAK--PGEESSSTKAITDAVVEAI 356 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Heyndrickxia coagulans] Sequence ID: P12010.1 Length: 366 Range 1: 5 to 355 Score:98.2 bits(243), Expect:2e-21, Method:Compositional matrix adjust., Identities:104/409(25%), Positives:179/409(43%), Gaps:79/409(19%) Query 39 IPFIEGDGIGIDIAP----VMKNVVD-----AAVEKSYAGKRKIEWMEIYAGEKATKVYG 89 + + GDGIG ++ V+K V+D A E + G I+ E T Sbjct 5 LAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAVFENALIGGAAID-------EAGTP--- 54 Query 90 KDNWLPDETLEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRY 143 LP+ETL+ + A+ GP +R + LR+++ L+ LRPV+ Sbjct 55 ----LPEETLDICRRSDAILLGAVGGPKWDHNPASLRPEKGLLGLRKEMGLFANLRPVKA 110 Query 144 FTGV--PSPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIR 199 + + SP+K E V++VI RE + +Y G P ++++ L Sbjct 111 YATLLNASPLKRERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTLA--------- 161 Query 200 FPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVA 259 ++E R++ +A Q A R + V K N+++ + + W E+A Sbjct 162 -----------YTREEIERIIEKAFQLA-QIRRKKLASVDKANVLESS----RMW-REIA 204 Query 260 VKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYI 319 E K + + ++ D+ Q++ P ++ VI T N+ GD + Sbjct 205 E----------------ETAKKYPDVELSHMLVDSTSMQLIANPGQFDVIVTENMFGDIL 248 Query 320 SDALAAEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-L 377 SD + G +G+ P A+L SD G++E HG+AP AGQ K NP +LSA +MLRY Sbjct 249 SDEASVITGSLGMLPSASLRSDRFGMYEPVHGSAPDIAGQGKANPLGTVLSAALMLRYSF 308 Query 378 GWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 G ++ A + + ++ ++ T D + K VST + +I+ + Sbjct 309 GLEKEAAAIEKAVDDVLQDGYCTGDLQ--VANGKVVSTIELTDRLIEKL 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Rhodococcus jostii RHA1] Sequence ID: Q0S2H1.1 Length: 336 Range 1: 3 to 332 Score:97.8 bits(242), Expect:2e-21, Method:Compositional matrix adjust., Identities:108/391(28%), Positives:164/391(41%), Gaps:68/391(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG+++ V+ V ++ E G + G+ LPD Sbjct 3 LAVIPGDGIGVEVTAEALKVLRKLVPD-------LQTTEYDLGARRYNATGE--LLPDAD 53 Query 99 LEAIKEYQVAIKGPLTTP-VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 L AI+E+ + G + P V G+ R L + +R LD +V LRP + + G SP+ Sbjct 54 LAAIREHDAILLGAIGDPSVTPGVLERGLLLNMRFALDHHVNLRPSQLYPGSKSPLAAQP 113 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 ++ V+ RE +E Y G G ++ P + + G Sbjct 114 DIDFVVVREGTEGPYTG-------------------NGGAIRVGTPHEIATEVSINTWFG 154 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 R+VR A A R VTL+HK N++ GA E E+ ++ H+ Sbjct 155 AERVVRYAFALA-QTRRKHVTLIHKTNVLS-NAGAIWTRAVETVSAEY--PDVETAYCHI 210 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 DA ++ P+ + VI T NL GD I+D A GGIG+A Sbjct 211 -----------------DAATIYMVTDPSRFDVIVTDNLFGDIITDLAGAVTGGIGLAAS 253 Query 336 ANLSDTVG----LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVVQGIE 391 N+ D G +FE HG+AP AGQ +P + ILSA ++LR+LG A + +E Sbjct 254 GNI-DASGTNPSMFEPVHGSAPDIAGQGIADPTAAILSAALLLRHLGRDGDAARIEAAVE 312 Query 392 GAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 + S+ G +V TS+ G I Sbjct 313 ADLASR-----------GDSKVVTSEVGDRI 332 >RecName: Full=Probable tartrate dehydrogenase/decarboxylase; Short=TDH; AltName: Full=D-malate dehydrogenase [decarboxylating] [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P42958.4 Length: 354 Range 1: 8 to 312 Score:97.4 bits(241), Expect:3e-21, Method:Compositional matrix adjust., Identities:90/358(25%), Positives:154/358(43%), Gaps:68/358(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVE----KSYAGKRKIEWMEIYAGEKATKVYGKDNWL 94 I I GDG+G ++ + V+ A E S++ W Y E +GK + Sbjct 8 IAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFT-AFPWSCDYYLE-----HGK--MM 59 Query 95 PDETLEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSP 150 P++ + + +++ A+ P P + L + +R++L+L + +RP + G+ SP Sbjct 60 PEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSP 119 Query 151 VKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKP 210 + P + V+ RENSE Y+ E+G + R + I Sbjct 120 LLHPNDFDFVVIRENSEGEYS--------------------EVGGRIHRGDDEIAIQNAV 159 Query 211 VSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGN----IMKFTEGAFKDWGYEVAVKEFGAK 266 +++ T R++R A + A R VT K N M F + F+ + + E ++ Sbjct 160 FTRKATERVMRFAFELA-KKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ 218 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 + DA + RP + VI NL GD ++D ++ Sbjct 219 HI------------------------DALAAFFVTRPETFDVIVASNLFGDILTDISSSL 254 Query 327 VGGIGIAPGANLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE 381 +G IGIAP AN++ + +FE HG+AP AGQ NP I +A++ML + G +E Sbjct 255 MGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEE 312 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bordetella avium 197N] Sequence ID: Q2KYL5.1 Length: 358 Range 1: 5 to 357 Score:97.4 bits(241), Expect:3e-21, Method:Compositional matrix adjust., Identities:114/406(28%), Positives:171/406(42%), Gaps:71/406(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ AV A +E E G A + ++ LP T Sbjct 5 IAVLPGDGIGPEI-------VEQAVRVLQALNLPLELQEAKVGGAAFDAF--EHPLPPAT 55 Query 99 LEAIKEYQVAIKGPL------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 L K + G + + P + LR+ L L+ LRP + + S Sbjct 56 LGLAKSSHAVLFGAVGDWKYDSLPREFRPEQAILGLRRALGLFANLRPAILYPELASASS 115 Query 153 -TPEKV---NMVIFRENSEDIYAGIEWPAG---SPEAVKLINFLQNEMGVKKIRFPETAG 205 PE V +++I RE + DIY G P G +P+ V F G +R+ E+ Sbjct 116 LKPEIVAGLDIIIIRELTGDIYFGT--PRGVRSAPDGV----FSGEREGYDTMRYAESE- 168 Query 206 IGIKPVSKEGTSRLVRRAIQYAIDNDRD---SVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 VRR + R + V K N+++ T ++D EVA +E Sbjct 169 --------------VRRIAHVGFETARKRNKKLCSVDKANVLE-TSQFWRDIVIEVA-RE 212 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 + + + + D Q++ P ++ VI T NL GD +SD Sbjct 213 Y-------------------PDVELSHMYVDNAAMQLVRNPRQFDVIVTGNLFGDILSDE 253 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWK 380 A G IG+ P A+L+ + GL+E +HG+AP AGQ NP + ILSA M+LRY L Sbjct 254 AAMLTGSIGMLPSASLNASGQGLYEPSHGSAPDIAGQGIANPLATILSAAMLLRYSLNQP 313 Query 381 EAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 AD + + + T D G +VSTSQ G A++K + Sbjct 314 AQADRIEAAVRKVLAQGLRTADIHE--AGTTKVSTSQMGDAVLKAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Chromobacterium violaceum ATCC 12472] Sequence ID: Q7NUC2.1 Length: 354 Range 1: 3 to 351 Score:97.4 bits(241), Expect:4e-21, Method:Compositional matrix adjust., Identities:109/397(27%), Positives:174/397(43%), Gaps:60/397(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I + V++ KIE G A YG P+ T Sbjct 3 IAILPGDGIGPEIIAQAERVLEVLRRDGL----KIETEHAPLGGAAYDQYGVP--YPEAT 56 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRP-VRYFTGVPSPV 151 + +E + G + P + R L +A+R+ L+L+ LRP + Y + Sbjct 57 QKLAREADAVLLGAVGGPAYDKLDRPLRPERGLLAIRKDLNLFANLRPAILYPELANAST 116 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + DIY G P + +N L +R+ E+ Sbjct 117 LKPEVVAGLDIMIVRELTGDIYFG------QPRGIA-VNELGEREAYNTMRYSESE---- 165 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 R+ A A+ +R + V K N+++ TE +K+ EVA KE+ Sbjct 166 -------VRRIAHVAFGIAMKRNRKLCS-VDKANVLETTE-FWKEIMIEVA-KEY----- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 ++ + + D Q++ P ++ V+ T N+ GD +SD + G Sbjct 211 --------------PQVELSHMYVDNAAMQLVRNPKQFDVMVTGNIFGDILSDEASMLTG 256 Query 329 GIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 IG+ P A+L + GL+E +HG+AP AGQ+ NP + ILSA MMLRY G + AA V Sbjct 257 SIGMLPSASLDQNNKGLYEPSHGSAPDIAGQNLANPLATILSAAMMLRYSFGQEAAARRV 316 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 ++ + T D G ++VS S G A++ Sbjct 317 EDAVKKVLAQGYRTADIYE--AGCEKVSCSGMGDAVV 351 >RecName: Full=3-isopropylmalate dehydrogenase 2; AltName: Full=3-IPM-DH 2; AltName: Full=Beta-IPM dehydrogenase 2; Short=IMDH 2 [Dechloromonas aromatica RCB] Sequence ID: Q479H7.1 Length: 358 Range 1: 3 to 347 Score:96.7 bits(239), Expect:7e-21, Method:Compositional matrix adjust., Identities:110/394(28%), Positives:173/394(43%), Gaps:62/394(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I I GDGIG++I V+DA K G KIE+ G A G+ LP ET Sbjct 3 ICVIPGDGIGVEICAEAVRVIDAL--KDIHGL-KIEYEYGLLGGAAYDQTGRP--LPVET 57 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP-SP 150 L E + G + P + R L + +R+ L L LRP++ + + + Sbjct 58 LRLADEANAILLGAVGGPKWDKLPAESRPERGL-LGIRKYLGLNANLRPIKVYPELANAS 116 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V +M+I RE + DIY G P ++ F +G + + E+ Sbjct 117 TLRPEVVSGLDMMIVRELTGDIYFG------QPRGIRTSGF--ERVGYNTMEYSESE--- 165 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 + E R+ R+ V V K N+++ + ++D V + G + Sbjct 166 -IALIAEMAFRIARQR--------SGKVMSVDKMNVLECMQ-LWRD-----VVTKVGERF 210 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 D +T+ ++ D Q++ P ++ V+ T N+ GD +SD A Sbjct 211 PD---------------VTLDHMLVDNAAMQLVKNPKQFDVLLTGNMFGDILSDEAAMLT 255 Query 328 GGIGIAPGANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L+ + G++E HG+AP AGQ NP +ILSA MM RY LG + AD Sbjct 256 GSIGMLPSASLNVEDKGMYEPCHGSAPDIAGQGVANPLGMILSAAMMFRYSLGRPDMADA 315 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFG 419 + ++ + + T D G + VSTS+ G Sbjct 316 IESAVQTVLTNGARTRDI--FQAGDRLVSTSEMG 347 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Burkholderia lata] Sequence ID: Q393X4.1 Length: 355 Range 1: 3 to 352 Score:96.3 bits(238), Expect:7e-21, Method:Compositional matrix adjust., Identities:111/401(28%), Positives:180/401(44%), Gaps:67/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ AV+ A K E + G + G + LPD T Sbjct 3 IAVLPGDGIGPEI-------VNEAVKVLNALDEKFELEQAPVGGAGYEASG--HPLPDAT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYFTGV--PSP 150 L+ KE + G + + R+L + LR+ L+L+ RP + + SP Sbjct 54 LKLAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASP 113 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAG---SPEAVKLINFLQNEMGVKKIRFPETA 204 +K PE V +++I RE + DIY G P G +P+ + F G +R+ E Sbjct 114 LK-PELVAGLDILIVRELNGDIYFG--QPRGVRTAPDGL----FAGEREGFDTMRYSEPE 166 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 I V+ + + ++ + V K N+++ T ++D +V+ KE+ Sbjct 167 VRRIAHVAFQAARKRAKKLLS------------VDKANVLE-TSQFWRDIMIDVS-KEYA 212 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 + + + D Q+ P ++ VI T N+ GD +SD + Sbjct 213 -------------------DVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEAS 253 Query 325 AEVGGIGIAPGANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L + GL+E +HG+AP AG+ NP + ILSA MMLRY L E Sbjct 254 MLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATILSAAMMLRYSLNRAEQ 313 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 AD + + ++ +E T D A G ++V T+ G A++ Sbjct 314 ADRIERAVKTVLEQGYRTGDIA--TPGGQQVGTTAMGDAVV 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Desulfotalea psychrophila LSv54] Sequence ID: Q6ANR1.1 Length: 357 Range 1: 4 to 354 Score:96.3 bits(238), Expect:1e-20, Method:Compositional matrix adjust., Identities:110/402(27%), Positives:176/402(43%), Gaps:68/402(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+ AV+K + + + ++ G A +G LP+ T Sbjct 4 IAVLAGDGIGPEVMEQALKVL-VAVQKKFGFELSFQHADV--GGAAIDSHGV--ALPEST 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 L E + G + P + R+ + LR+ DL+ RP R F + + Sbjct 59 LTLCAESDAILFGSVGGPKWEHLPPAEQPERAALLPLRKHFDLFCNYRPARVFKSLTAAC 118 Query 150 PVKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + +++ RE + IY G P G E + + MG K+ Sbjct 119 PLRADIIGDGFDILCVRELTSGIYFGT--PKGR-EGAGEDEYAYDTMGYKRSE------- 168 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRD---SVTLVHKGNIMKFTEGAFKDWGYEVAVKEF 263 VRR A R VT V K N++ T +++ EVA KE+ Sbjct 169 -------------VRRIAHMAFAAARQRSGKVTSVDKANVLT-TMVLWREVVLEVA-KEY 213 Query 264 GAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDAL 323 L+ H++ + T Q++ P ++ V+ N+ GD ISD Sbjct 214 PDVKLN----HIYVDNAT---------------MQLVRDPHQFDVMLCGNMFGDIISDEA 254 Query 324 AAEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKE 381 A G +G+ A+L ++ GLFE G+AP AGQ NP + ILSA MMLRY LG+ E Sbjct 255 AMLTGSMGLLASASLNTENFGLFEPAGGSAPDIAGQGIANPIAEILSAAMMLRYSLGYGE 314 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 AAD + +E ++ T D A + ++ V+T++ G AI+ Sbjct 315 AADAIEAAVEKTLDRGICTADIA--VDRSQAVNTAEMGDAIV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Haemophilus influenzae 86-028NP] Sequence ID: Q4QLS3.1 Length: 358 Range 1: 6 to 358 Score:95.5 bits(236), Expect:1e-20, Method:Compositional matrix adjust., Identities:105/402(26%), Positives:170/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG ++ V++ EK K+ + E + G A G LP ET Sbjct 6 VAVLAGDGIGPEVMAEAMKVLNKVQEKF---GFKLNFNEFFVGGAAIDHCGYP--LPAET 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 L+ E + G + P + R + LR+ L+ LRP + G+ Sbjct 61 LKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFC 120 Query 150 PVKT---PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + +MV+ RE + IY G P G ++ +T Sbjct 121 PLRADIAAKGFDMVVVRELTGGIYFG--QPKG-----------------REGEGSQTKAF 161 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + K R+ R A + A+ ++ VT V K N+++ + + +E Sbjct 162 DTEVYYKYEIERIARAAFEAAMKRNK-KVTSVDKANVLQSS----------ILWRE---- 206 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V E K ++T++ + D Q++ P + V+ N+ GD ISD A Sbjct 207 -------TVTEMAKDYPEVTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMI 259 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG+ NP + ILSA MMLRY EAAD Sbjct 260 TGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLNEAAD 319 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + S T D A T VST++ G I + I Sbjct 320 AIESAVQKVLASGHRTADLADDST---PVSTAEMGTLITQAI 358 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Lactococcus lactis subsp. lactis Il1403] Sequence ID: Q02143.3 Length: 345 Range 1: 8 to 344 Score:95.1 bits(235), Expect:2e-20, Method:Compositional matrix adjust., Identities:99/393(25%), Positives:175/393(44%), Gaps:64/393(16%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 + GDGIG +I +V+ AV K + ++E + G A +G + LP+ETL+A Sbjct 8 LAGDGIGPEIMSAGLSVL-KAVSKKIDFEYELEAKDF--GGIAIDKHG--HPLPEETLQA 62 Query 102 IKEYQVAIKGPLTTPV--GGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP--SPVKTPE 155 +K + + P +R +ALR++L LY +RP++ + + SP++ E Sbjct 63 VKNADAILLAAIGHPKYNNAKVRPEQGLLALRKELGLYANVRPLKIYPALKKLSPIRNVE 122 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 V+ ++ RE + IY G Q+E+ K R + S + Sbjct 123 NVDFLVIRELTGGIYFG-----------------QHELADDKAR-------DVNDYSADE 158 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 R++ A + A R +T V K N++ T ++ E+A D P Sbjct 159 IRRILHFAFKSAQSRPRKLLTSVDKQNVLA-TSKLWRKMADEIA---------DEYP--- 205 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 + ++ + D+ ++ P ++ VI T NL GD +SD ++ G +G+ P Sbjct 206 --------DVRLEHQLVDSCAMLLITNPQQFDVIVTENLFGDILSDEASSLAGSLGVMPS 257 Query 336 ANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR-YLGWKEAADLVVQGIEGA 393 ++ + + L+E HG+AP AG+ NP S+ILS MMLR G ++ A ++ + + Sbjct 258 SSHGFNGLALYEPIHGSAPDIAGKGIANPVSMILSIAMMLRESFGQEDGAAMIEKAVTQT 317 Query 394 IESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +T D T T + +AI+K+ Sbjct 318 FTDGILTKDLGGTAT------TKEMTEAILKNC 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Clostridium acetobutylicum ATCC 824] Sequence ID: Q97EE2.1 Length: 357 Range 1: 6 to 357 Score:95.1 bits(235), Expect:2e-20, Method:Compositional matrix adjust., Identities:112/401(28%), Positives:178/401(44%), Gaps:62/401(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG++I V++ K K + E+ AG A +G LP+ET Sbjct 6 VAVIPGDGIGVEIVGEALKVLEKVGAKY---DTKFNFTEVKAGGCAIDEFGVP--LPNET 60 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIR--SLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 LE K A+ GP + G R + LR L LY LRP + + + S Sbjct 61 LEICKNSDAVLLGAVGGPKWDTLPGEKRPEKALMGLRGGLGLYANLRPAKVYDILKSASP 120 Query 153 TPEK-----VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 E+ V++++ RE + IY G E G + I+ + Sbjct 121 LKEEIINKGVDLLVVRELTGGIYFG-------------------ERG-RDIQNGINSAYD 160 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 + + E R+ A + A+ ++ VT V K NI++ + +++ EVA KE+ Sbjct 161 TERYNVEEIKRIAHVAFKAALKRNK-KVTSVDKANILESSR-LWRETVTEVA-KEY---- 213 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 ++ + + D Q++ P+++ VI T N+ GD ++D + Sbjct 214 ---------------PEVELNYLYVDNAAMQLVREPSQFDVIVTSNIFGDILTDEASMVT 258 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L +DT G++E HG+AP AGQD NP + ILS MML Y EAA Sbjct 259 GSIGMLPSASLRNDTFGMYEPIHGSAPDIAGQDLANPLAQILSVAMMLEYSFNMTEAARD 318 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 V +E + S T D G+K+V T + GK ++ + Sbjct 319 VEDAVEKVLNSGYRTGDI--YTEGSKKVGTKEMGKLVLAEL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Shouchella clausii KSM-K16] Sequence ID: Q5WEN4.1 Length: 364 Range 1: 5 to 356 Score:95.1 bits(235), Expect:2e-20, Method:Compositional matrix adjust., Identities:104/400(26%), Positives:175/400(43%), Gaps:60/400(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I K V++ E + +++E G A G + LP+ET Sbjct 5 ILLLPGDGIGPEIIAETKRVLE---EIARLYHHTFQFVEGRIGGDAIDATG--SPLPEET 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN------VALRQQLDLYVCLRPVRYFTGVPSPVK 152 L+ K + G + P G + +R+ L LY LRPVR + Sbjct 60 LDLAKGSDAILLGAVGGPKWDGNAPEKRPEKGLLQIRKALGLYANLRPVRVLKPLMGAST 119 Query 153 TPEKV----NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 E+V +++I RE + +Y G P + IN E + Sbjct 120 LKEEVLADVDLLIVRELTGGLYFG------EPRERRQIN-------------GEDGAVDT 160 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 ++ R+V +A Q+A + V+ V K N+++ + +++ EVA +E+ Sbjct 161 LLYTRGEIERIVHQAFQFARTRKKRVVS-VDKANVLESSR-LWREIADEVA-REY----- 212 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 +T+ ++ D Q++ P ++ VI T NL GD +SD + G Sbjct 213 --------------PDVTLSHMLVDNAAMQLIRDPRQFDVIVTENLFGDILSDEASMITG 258 Query 329 GIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 +G+ P A+++ + VGLFE HG+AP AG NP + ILSA MML+Y G + A + Sbjct 259 SLGLLPSASMNTSKVGLFEPVHGSAPDIAGTGAANPLATILSAAMMLQYSFGLADEAKAI 318 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++ + T D A+ A VST+ A+++ + Sbjct 319 EVAVDRVLAQGVRTKDIAKASENA--VSTTAITNAVMEAL 356 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Neisseria gonorrhoeae FA 1090] Sequence ID: Q5F8T6.1 Length: 356 Range 1: 5 to 353 Score:95.1 bits(235), Expect:2e-20, Method:Compositional matrix adjust., Identities:107/398(27%), Positives:175/398(43%), Gaps:62/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+D + + + + G +A YG + P+ T Sbjct 5 IAILRGDGIGPEIVAETVRVLDKFIAQGLDADYEYAPL----GGEAYDEYG--HPYPEFT 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRP-VRYFTGVPSPV 151 ++ + G + +P + R L +A+R+ L+L+ LRP V Y + Sbjct 59 QNLCRKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAVLYPELANAST 118 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + DIY G P ++++ ++E G +++ E+ Sbjct 119 LKPEIVAGLDILIVRELTGDIYFG------EPRGIRVLENGEHE-GYNTMKYSESE---- 167 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 R+ A Q A + V V K N+++ TE W Sbjct 168 -------IRRIAHVAFQSAQKRSK-KVCSVGKANVLETTEL----W-------------- 201 Query 269 DGGPWHVFEN-PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 +FE K + + + D Q++ P ++ VIAT N+ GD +SD + Sbjct 202 ----REIFEEIGKQYPDVELSHMYVDNAAMQLVRAPKQFDVIATGNIFGDILSDEASMLT 257 Query 328 GGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEA-ADL 385 G IG+ P A+L + GL+E +HG+AP AGQ+K NP + ILS M+LRY EA A Sbjct 258 GSIGMLPSASLDENGKGLYEPSHGSAPDIAGQNKANPLATILSLAMLLRYSLNDEARAQQ 317 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 V ++ ++ T D G K VS S+ G A++ Sbjct 318 VENSVQKVLQQGLRTGDIYE--EGTKLVSCSEMGDAVL 353 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Neisseria meningitidis MC58] Sequence ID: Q9JZI9.1 Length: 356 Range 1: 5 to 353 Score:94.7 bits(234), Expect:3e-20, Method:Compositional matrix adjust., Identities:110/399(28%), Positives:177/399(44%), Gaps:64/399(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSY-AGKRKIEWMEIYAGEKATKVYGKDNWLPDE 97 I + GDGIG +I V+D + + AG E+ + G +A YG + P+ Sbjct 5 IAILRGDGIGPEIVAETVRVLDKLIAQGLDAG---YEYAPL--GGEAYDEYG--HPYPEF 57 Query 98 TLEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRP-VRYFTGVPSP 150 T ++ + G + +P + R L +A+R+ L+L+ LRP V Y + Sbjct 58 TQNLCRKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAVLYPELANAS 117 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V +++I RE + DIY G P ++++ + E G +++ E+ Sbjct 118 TLKPEIVAGLDILIVRELTGDIYFG------EPRGIRVLENGERE-GYNTMKYSESE--- 167 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 R+ A Q A + V V K N+++ TE W Sbjct 168 --------IRRIAHVAFQSAQKRSK-KVCSVGKANVLETTEL----W------------- 201 Query 268 LDGGPWHVFEN-PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 +FE K + + + D Q++ P ++ VIAT N+ GD +SD + Sbjct 202 -----REIFEEIGKEYPDVELSHMYVDNAAMQLVRAPKQFDVIATGNIFGDILSDEASML 256 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEA-AD 384 G IG+ P A+L + GL+E +HG+AP AGQ+K NP + ILS M+LRY EA A Sbjct 257 TGSIGMLPSASLDENGKGLYEPSHGSAPDIAGQNKANPLATILSLAMLLRYSLNDEARAQ 316 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 V ++ ++ T D G K VS S+ G A++ Sbjct 317 QVENAVQKVLQQGLRTSDIYE--EGTKLVSCSEMGDAVL 353 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Burkholderia multivorans ATCC 17616] Sequence ID: Q845W3.1 Length: 355 Range 1: 3 to 352 Score:94.7 bits(234), Expect:3e-20, Method:Compositional matrix adjust., Identities:110/401(27%), Positives:176/401(43%), Gaps:67/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V AV+ A K E + G + G + LPD T Sbjct 3 IAVLPGDGIGPEI-------VTEAVKVLNALDEKFELEQAPVGGAGYEARG--HPLPDAT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYFTGV--PSP 150 L+ KE + G + + R+L + LR+ L+L+ RP + + SP Sbjct 54 LKLAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASP 113 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLIN---FLQNEMGVKKIRFPETA 204 +K PE V +++I RE + DIY G P V+ F G +R+ E Sbjct 114 LK-PELVAGLDILIVRELNGDIYFG------QPRGVRAAPDGPFAGEREGFDTMRYSEPE 166 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 I V+ + + ++ + V K N+++ T ++D +V+ KE+ Sbjct 167 VRRIAHVAFQAAQKRAKKLLS------------VDKSNVLE-TSQFWRDIMIDVS-KEYA 212 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 + + + D Q+ P ++ VI T N+ GD +SD + Sbjct 213 -------------------DVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEAS 253 Query 325 AEVGGIGIAPGANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L + GL+E +HG+AP AG+ NP + ILSA M+LRY L E Sbjct 254 MLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATILSAAMLLRYSLNRAEQ 313 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 AD + + ++ +E T D A G K+V T+ G A++ Sbjct 314 ADRIERAVKTVLEQGYRTGDIA--TPGCKQVGTAAMGDAVV 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Methylococcus capsulatus str. Bath] Sequence ID: Q606F4.1 Length: 360 Range 1: 5 to 357 Score:94.7 bits(234), Expect:3e-20, Method:Compositional matrix adjust., Identities:112/403(28%), Positives:173/403(42%), Gaps:65/403(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+D +S G +E G A +G P ET Sbjct 5 IAVLPGDGIGPEIVAEALKVLDCL--RSDFGL-AVETEHALIGGAAYDAHGTP--FPKET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 LE + A+ GP P+ +R + LR +L+L+ LRP V Y V + Sbjct 60 LELCRAADSILLGAVGGPKWEPLDYSLRPERGLLGLRSELELFSNLRPAVLYPQLVSAST 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G P ++ NE G E G Sbjct 120 LKPEVVAGLDIMIVRELTGGIYFG------KPRGRRI-----NEDG-------EREGYNT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 S+ R+ A Q A +R + + K N+++ TE Sbjct 162 LVYSESEIRRIAHSAFQIARKRNR-RLCSIDKANVLECTE-------------------- 200 Query 269 DGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 W V E K + + + D Q++ P ++ V+ T N+ GD +SD A Sbjct 201 ---LWREVVIEVGKDYPDVALSHMYVDNAAMQLVRNPKQFDVMLTDNMFGDILSDCAAML 257 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEA--A 383 G IG+ P A+L+++ G++E HG+AP AG+ NP + ILS MMLRY + +A A Sbjct 258 TGSIGMLPSASLAESGKGMYEPIHGSAPDIAGRGIANPIATILSLAMMLRY-SFDDAVSA 316 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + + ++ A++ T D A G EV T+ G AI+ + Sbjct 317 ERIGKAVQTALDQGFRTADIAS--EGTVEVGTAAMGDAIVAAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Parasynechococcus marenigrum WH 8102] Sequence ID: Q7U840.1 Length: 357 Range 1: 8 to 357 Score:94.7 bits(234), Expect:3e-20, Method:Compositional matrix adjust., Identities:105/401(26%), Positives:171/401(42%), Gaps:66/401(16%) Query 41 FIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLE 100 + GDGIG +I V + +++A V + + + + I G A G+ LP TL+ Sbjct 8 LLPGDGIGPEITAVARQLLEA-VSQRHGFELCFDGQLI--GGSAIDACGEP--LPASTLD 62 Query 101 AIKEYQVAIKGPLTTPVGGGI------RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 A K + + +P + + + LR + L+ LRPV+ VP+ + Sbjct 63 ACKAADAVLLAAIGSPRFDNLPRDKRPETGLLGLRSGMALFANLRPVKI---VPALIGAS 119 Query 155 -------EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 E V++++ RE + IY G P G +A E G Sbjct 120 SLRPEVIEGVDLMVVRELTGGIYFG--QPKGRIQADG-----------------EERGFN 160 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S R+ R A A + R ++ V K N++ ++ ++D +A Sbjct 161 TMTYSSSEVDRIARVAFDLARER-RGNLCSVDKANVLDVSQ-LWRDRVDAMA-------- 210 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 P + + + + D Q++ P ++ V+ T NL GD +SD A Sbjct 211 ----PAY--------SDVEVSHMYVDNAAMQLVRSPRQFDVLLTGNLFGDILSDEAAMLT 258 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L SD GLFE HG+AP AGQDK NP +++LSA MMLR L EAA Sbjct 259 GSIGMLPSASLGSDCPGLFEPVHGSAPDIAGQDKANPMAMVLSAAMMLRIGLKQTEAAAD 318 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + + T D + G + G A++K + Sbjct 319 LEAAVDKVLAAGFRTGDL--MAEGCTALGCRAMGDALLKAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Caldanaerobacter subterraneus subsp. tengcongensis MB4] Sequence ID: Q8RDK0.1 Length: 355 Range 1: 4 to 353 Score:94.7 bits(234), Expect:3e-20, Method:Compositional matrix adjust., Identities:109/406(27%), Positives:174/406(42%), Gaps:74/406(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+ A VE+ Y + I+ G +A YG+ P+ET Sbjct 4 IAVLPGDGIGPEVIEEGLKVLKA-VEEKYGLRFDIKKYPF--GGEAIDKYGEP--YPEET 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN------VALRQQLDLYVCLRPVRYFTGV--PSP 150 + G + P G+ +ALR+ L +Y LRP + + SP Sbjct 59 RNGCLSSDAVLLGAVGGPKWDGLEGDKRPEAGLLALRKSLGVYANLRPAVLYPSLKDASP 118 Query 151 VKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 +K + +++++ RE + IY G P G E G G Sbjct 119 LKNELLEKGLDILVVRELTGGIYFG---PRGK----------------------EAIGYG 153 Query 208 IKPVSKE-----GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 + E R+ A + A+ R +T V K N+++ + + W V Sbjct 154 FRAYDTEVYETQEIERIAVIAFEAALRR-RKKITSVDKANVLESS----RLWRKTVE--- 205 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 E K ++ + + D Q++ P ++ VI T N+ GD +SD Sbjct 206 --------------EVAKRYPEVELNHMYVDNCAMQLVKNPFQFDVILTNNMFGDILSDE 251 Query 323 LAAEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWK 380 A VG IGI P A+L D VGL+E HG+AP AG+ NP + ILS MML+Y G + Sbjct 252 AAQIVGSIGILPSASLRGDRVGLYEPIHGSAPDIAGKKIANPLATILSVAMMLQYSFGEE 311 Query 381 EAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 EAA + + +E A+E T D + + +ST + G ++++I Sbjct 312 EAAQDIRKAVERALEEGFRTADLGKGIV----LSTEEMGDKVVEYI 353 >RecName: Full=3-isopropylmalate dehydrogenase 3, chloroplastic; Short=3-IPM-DH 3; Short=AtIMDH2; Short=AtIMDH3; Short=IMDH 3; AltName: Full=Beta-IPM dehydrogenase 3; AltName: Full=Isopropylmalate dehydrogenase 3; Short=AtIMD3; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q9SA14.2 Length: 404 Range 1: 40 to 398 Score:95.1 bits(235), Expect:3e-20, Method:Compositional matrix adjust., Identities:112/413(27%), Positives:176/413(42%), Gaps:73/413(17%) Query 33 VPDRPIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDN 92 V R I + GDGIG ++ V KNV+ A + + ++ E+ G A + G Sbjct 40 VKKRYNITLLPGDGIGPEVISVAKNVLQKA---GFLQGLEFDFQEMPFGGAALDLVGVP- 95 Query 93 WLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLN----------VALRQQLDLYVCLRPVR 142 LP+ET A K+ + G +GG N + +R+ L+++ LRP Sbjct 96 -LPEETSTAAKQSDAILLGA----IGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPA- 149 Query 143 YFTGVPSPV-------KTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGV 195 T +P V + + V+M+I RE + IY G P + + NE G Sbjct 150 --TVLPQLVDASTLKKEVAQGVDMMIVRELTGGIYFG------EPRGITI-----NENG- 195 Query 196 KKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWG 255 E G + + R+ R A + A R + V K N++ A W Sbjct 196 ------EEVGFNTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD----ASILWR 244 Query 256 YEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLN 315 V E P + + + D Q++ P ++ I T N+ Sbjct 245 KRVTA-------------LASEYPD----VELSHMYVDNAAMQLVRDPKQFDTIVTNNIF 287 Query 316 GDYISDALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMML 374 GD +SD + G IG+ P A+L ++ GLFE HG+AP AGQDK NP + ILSA M+L Sbjct 288 GDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLL 347 Query 375 RY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +Y LG ++AA ++ + A+ T D G K V + G+ ++K + Sbjct 348 KYGLGEEKAAKMIEDAVVDALNKGFRTGDI--YSPGNKLVGCKEMGEEVLKSV 398 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Synechocystis sp. PCC 6803 substr. Kazusa] Sequence ID: P73960.1 Length: 362 Range 1: 7 to 357 Score:94.7 bits(234), Expect:3e-20, Method:Compositional matrix adjust., Identities:107/399(27%), Positives:172/399(43%), Gaps:61/399(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEK-SYAGKRKIEWMEIYAGEKATKVYGKDNWLPDE 97 + + GDGIG +I V V+ ++ +A + E G A G+ LP+ Sbjct 7 VTLLPGDGIGPEIMAVAVAVLGKVADQFGFA----FNFQEALIGGAAIDATGQP--LPEA 60 Query 98 TLEAIKEYQVAIKGPL------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGV--PS 149 TL K+ + + P + +A+R+ L L+ LRP F + S Sbjct 61 TLAQAKDSDAVLLAAIGGYAWDNLPRSQRPETGLLAIREGLGLFANLRPATIFPQLIDAS 120 Query 150 PVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 +K E V++++ RE + IY G P+ + + E G K+ G+ Sbjct 121 SLKREVVEGVDIMVVRELTGGIYFG------KPKGI-----FETETGEKR-------GVN 162 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 + R+ + A + A R + V K N++ ++ ++D +AV Sbjct 163 TMAYTVGEIDRIAKVAFETA-RKRRGQLCSVDKANVLDVSQ-LWRDRVMAIAV------- 213 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 + P + + + D Q++ P ++ I T NL GD +SD A Sbjct 214 ---------DYPD----VELSHLYVDNAAMQLVRSPRQFDTIVTGNLFGDILSDIAAMLT 260 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L SD GLFE HG+AP AGQDK NP + +LSA MMLRY L +AAD Sbjct 261 GSIGMLPSASLGSDGPGLFEPVHGSAPDIAGQDKANPLAQVLSAAMMLRYGLDQPQAADR 320 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 + ++ +E T D L G + V Q G+ ++ Sbjct 321 LEDAVKKVLEQGYRTGDI--LSPGTQLVGCRQMGEQLLS 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Psychrobacter arcticus 273-4] Sequence ID: Q4FRV0.1 Length: 367 Range 1: 4 to 367 Score:94.7 bits(234), Expect:4e-20, Method:Compositional matrix adjust., Identities:110/409(27%), Positives:178/409(43%), Gaps:65/409(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I +V++A V +A +E I G A G+ LP+ET Sbjct 4 ILTLAGDGIGPEIMTQAIDVLNA-VNNKFALGLTLESGLI--GGVAVDATGEP--LPEET 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGV--PS 149 L+ + + G + P GI R L + +R +L L+ LR + + + S Sbjct 59 LQRARAADAVLLGAVGGPKWDGIERSKRPERGL-LKIRSELGLFANLRVAKLYPQLVNAS 117 Query 150 PVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 +K PE + +++I RE + IY G P G++ + E G Sbjct 118 SIK-PEIISGLDLLIVRELTGGIYFG------EPR------------GIRTLENGEQQGY 158 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDS-----VTLVHKGNIMKFTEGAFKDWGYEVAVK 261 S +R+ + A + A + + V + K N+++ TE +K E+ Sbjct 159 NTMVYSTSEINRIGKVAFELAQTRAQAAGTPAKVCSIDKANVLEVTE-LWKQTMIELQQA 217 Query 262 EFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISD 321 E+ + + + AD Q++ P ++ V+ T NL GD +SD Sbjct 218 EY-------------------SDVALSHMYADNACMQLIKDPKQFDVMVTGNLFGDILSD 258 Query 322 ALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWK 380 A G IG+ P A+L + G++E HG+AP AGQD NP + ILS MMLRY + Sbjct 259 EAAMLTGSIGMLPSASLDEAGKGMYEPCHGSAPDIAGQDIANPLATILSVAMMLRYTFKQ 318 Query 381 E-AADLVVQGIEGAIESKTVTYD-FARLMTGAKEVSTSQFGKAIIKHIL 427 E AA + Q + ++ T D R G +V Q G+A++ +L Sbjct 319 EVAAQAIEQAVSDVLDDGLRTVDILDRNEAGLIQVGCQQMGQAVLAKLL 367 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Haemophilus influenzae Rd KW20] Sequence ID: P43860.1 Length: 358 Range 1: 6 to 358 Score:94.4 bits(233), Expect:4e-20, Method:Compositional matrix adjust., Identities:107/402(27%), Positives:172/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V++ EK K+ + E + G A + G LP ET Sbjct 6 IAVLAGDGIGPEVMAEAIKVLNRVQEKF---GFKLNFNEFFVGGAAIEHCGYP--LPAET 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 L+ + + G + P + R + LR+ L+ LRP + G+ Sbjct 61 LKGCDQADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFC 120 Query 150 PVKT---PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + +MV+ RE + IY G P G + GV +T Sbjct 121 PLRADIAAKGFDMVVVRELTGGIYFG--QPKG-----------REGDGV------QTKAF 161 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + K R+ R A + A+ ++ VT V K N+++ + + +E Sbjct 162 DTEVYYKYEIERIARAAFEAAMKRNK-KVTSVDKANVLQSS----------ILWRE---- 206 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V E K ++T++ + D Q++ P + V+ N+ GD ISD A Sbjct 207 -------TVTEMAKDYPEVTLEHIYIDNATMQLIKSPESFDVLLCSNIFGDIISDEAAMI 259 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG+ NP + ILSA MMLRY EAAD Sbjct 260 TGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLNEAAD 319 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + S T D A T VST++ G I + I Sbjct 320 AIESAVQKVLASGHRTADLADDST---PVSTAEMGTLITQAI 358 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Burkholderia pseudomallei 1710b] Sequence ID: Q3JKG9.1 Length: 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Burkholderia mallei ATCC 23344] Sequence ID: Q62AI9.1 Length: 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Burkholderia pseudomallei K96243] Sequence ID: Q63JL2.1 Length: 355 Range 1: 3 to 352 Score:94.4 bits(233), Expect:4e-20, Method:Compositional matrix adjust., Identities:112/401(28%), Positives:175/401(43%), Gaps:67/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ AV+ A K E + G + G + LPD T Sbjct 3 IAVLPGDGIGPEI-------VNEAVKVLNALDEKFELEQAPVGGAGYEASG--HPLPDAT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYFTGV--PSP 150 L KE + G + + R+L + LR+ L+L+ RP + + SP Sbjct 54 LALAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASP 113 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLIN---FLQNEMGVKKIRFPETA 204 +K PE V +++I RE + DIY G P V+ F G +R+ E Sbjct 114 LK-PELVAGLDILIVRELNGDIYFG------QPRGVRAAPDGPFAGAREGFDTMRYSEPE 166 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 R+ A Q A + ++ V K N+++ T ++D +V+ KE+ Sbjct 167 -----------VRRIAHVAFQAARKRAKKLLS-VDKSNVLE-TSQFWRDVMIDVS-KEYA 212 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 + + + D Q+ P ++ VI T N+ GD +SD + Sbjct 213 -------------------DVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEAS 253 Query 325 AEVGGIGIAPGANLSD-TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L GL+E +HG+AP AG+ NP + ILSA M+LRY L E Sbjct 254 MLTGSIGMLPSASLDQRNKGLYEPSHGSAPDIAGKGIANPLATILSAAMLLRYSLNRAEQ 313 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 AD + + ++ +E T D A G K+V T+ G A++ Sbjct 314 ADRIERAVKAVLEQGYRTGDIA--TPGCKQVGTAAMGDAVV 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Acinetobacter baylyi ADP1] Sequence ID: Q6FEV6.1 Length: 359 Range 1: 5 to 355 Score:94.0 bits(232), Expect:5e-20, Method:Compositional matrix adjust., Identities:107/398(27%), Positives:169/398(42%), Gaps:60/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I + V+ EK G + W G A +G+ P T Sbjct 5 ILILAGDGIGPEIVGAAEQVLTKVNEKFELG---LTWEHGLLGGSAIDAHGEP--YPAVT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYFTGVP--SP 150 E K+ + G + P I RS+ + +R +L+L+ LRP + + S Sbjct 60 SEQAKKADAILLGAVGGPKWDTIERSIRPERGLLKIRSELNLFANLRPALLYPQLADASS 119 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 +K PE V +++I RE + IY G G++++ E G Sbjct 120 LK-PEIVAGLDILIVRELTGGIYFG------------------QPRGIRELENGEKQGYN 160 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S+ R+ + A + A V V K N+++ TE W V + P Sbjct 161 TDVYSESEIKRIAKVAFELAALRG-SKVCSVDKANVLEVTE----LWKQTVTELQQAQYP 215 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 I + + D Q++ P ++ VI T NL GD +SD A Sbjct 216 ----------------NIQLSHMYVDNAAMQLVRAPKQFDVIVTGNLFGDILSDEAAMLT 259 Query 328 GGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLV 386 G IG+ P A+L + G++E HG+AP AGQ+ NP + ILS MMLRY +EAA Sbjct 260 GSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKA 319 Query 387 VQGIEGAIESKTV-TYDFARLMTGAKEVSTSQFGKAII 423 ++ G + + + T D + G + V T + G+A++ Sbjct 320 IEDAVGQVLDQGLRTADI--MSEGMQRVGTVEMGQAVV 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Burkholderia thailandensis E264] Sequence ID: Q2T7H6.1 Length: 355 Range 1: 3 to 352 Score:93.6 bits(231), Expect:7e-20, Method:Compositional matrix adjust., Identities:109/401(27%), Positives:175/401(43%), Gaps:67/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ AV+ A K E G + G + LPD T Sbjct 3 IAVLPGDGIGPEI-------VNEAVKVLNALDEKFELEHAPVGGAGYEASG--HPLPDAT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYFTGV--PSP 150 L KE + G + + R+L + LR+ L+L+ RP + + SP Sbjct 54 LALAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASP 113 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLIN---FLQNEMGVKKIRFPETA 204 +K PE V +++I RE + DIY G P V+ F G +R+ E Sbjct 114 LK-PELVAGLDILIVRELNGDIYFG------QPRGVRAAPDGPFAGEREGFDTMRYSEPE 166 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 I V+ + + ++ + V K N+++ T ++D +V+ KE+ Sbjct 167 VRRIAHVAFQAAQKRAKKLLS------------VDKSNVLE-TSQFWRDVMIDVS-KEYA 212 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 + + + D Q+ P ++ VI T N+ GD +SD + Sbjct 213 -------------------DVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEAS 253 Query 325 AEVGGIGIAPGANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L + GL+E +HG+AP AG+ NP + ILSA M+LRY L E Sbjct 254 MLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATILSAAMLLRYSLNRAEQ 313 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 AD + + ++ +E T D A G ++V T+ G A++ Sbjct 314 ADRIERAVKTVLEQGYRTGDIA--TPGCRQVGTAAMGDAVV 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Streptococcus mutans UA159] Sequence ID: Q8DTG3.1 Length: 344 Range 1: 7 to 344 Score:93.2 bits(230), Expect:9e-20, Method:Compositional matrix adjust., Identities:110/400(28%), Positives:173/400(43%), Gaps:77/400(19%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEW-MEIYAGEKATKVYGKD---NWLPDE 97 + GDGIG +I V DA +K I + EI A KA G D + LPD+ Sbjct 7 LAGDGIGPEIMAAGLEVFDAVAQK-------INFDYEIEA--KAFGGAGIDASGHPLPDD 57 Query 98 TLEAIKEYQVAIKGPLTTPV--GGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP--SPV 151 TL A K + + +P +R +A+R++L+L+ +RPVR F + SP+ Sbjct 58 TLAAAKTADAILLAAIGSPQYDKAPVRPEQGLLAIRKELNLFANIRPVRIFDALRHLSPL 117 Query 152 KTPE--KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIK 209 K V+ V+ RE + IY G + E + I Sbjct 118 KAERIAGVDFVVVRELTGGIYFG------------------------QHTLTENSACDIN 153 Query 210 PVSKEGTSRLVRRAIQYAIDNDRDS-VTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 S R++R+A +AI R VT + K N++ T ++ EVA KE+ Sbjct 154 EYSASEIRRIMRKA--FAIARGRSKKVTSIDKQNVLA-TSKLWRQIAEEVA-KEY----- 204 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 +T++ + D+ ++ PA + V+ T NL GD +SD + G Sbjct 205 --------------SDVTLEHQLVDSAAMVMITNPACFDVVVTENLFGDILSDESSVLPG 250 Query 329 GIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR-YLGWKEAADLV 386 +G+ P A+ S++ L+E HG+AP AG+ NP S+ILS MMLR G A+++ Sbjct 251 TLGVMPSASHSESGPSLYEPIHGSAPDIAGKGIANPISMILSVAMMLRDSFGETAGAEMI 310 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + +T D L +T Q AII ++ Sbjct 311 EHAVNKTLTQGILTRDLGGL------ANTKQMTAAIIANL 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [[Bacillus] caldotenax] Sequence ID: P05644.1 Length: 366 Range 1: 6 to 305 Score:93.6 bits(231), Expect:9e-20, Method:Compositional matrix adjust., Identities:105/354(30%), Positives:154/354(43%), Gaps:71/354(20%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVE--KSYAGKRKIEWMEIYAGEKATKVYGKDNWLPD 96 I + GDGIG K V AVE K+ + E+ Y + LP+ Sbjct 6 IAVLPGDGIG-------KEVTSGAVEVLKAVGIRFGHEFTFEYGLIGGAAIDEAGTPLPE 58 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGIRSLN----------VALRQQLDLYVCLRPVRYFTG 146 ET+ +E + G VGG N +A+R+QLDLY LRPV + Sbjct 59 ETVRLCRESDAVLLGA----VGGPKWDDNPPHLRPEKGLLAIRKQLDLYANLRPVVCYDS 114 Query 147 V--PSPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPE 202 + SP+K + V+ VI RE + IY G P AV + E Sbjct 115 LVSRSPLKPDLVQGVDFVIVRELTGGIYFG------QPSAV--------------VENGE 154 Query 203 TAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 + KE R+VR A + A R VT V K N++ + +++ EVA E Sbjct 155 EKAVDTLLYKKEEIERIVRMAFELA-RGRRKKVTSVDKANVLSSSR-LWREVAEEVA-NE 211 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 F +T++ ++ D +Q ++ P ++ VI T N+ GD +SD Sbjct 212 F-------------------PDVTLEHMLVDMRMQ-LIRAPKQFDVIVTENMFGDILSDE 251 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR 375 + G +G+ P A+LS + L+E HG+AP AG +K NP + ILSA MMLR Sbjct 252 ASMLSGSLGMLPSASLSASGPSLYEPVHGSAPDIAGMNKANPIAAILSAAMMLR 305 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Cupriavidus metallidurans CH34] Sequence ID: Q1LKH7.1 Length: 355 Range 1: 3 to 352 Score:92.8 bits(229), Expect:1e-19, Method:Compositional matrix adjust., Identities:113/401(28%), Positives:169/401(42%), Gaps:67/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++A EK E G + G + LPD T Sbjct 3 IAVLPGDGIGPEIVAEAVKVLNALDEK-------FEMETAPVGGAGYEAEG--HPLPDNT 53 Query 99 LEAIKEYQVAIKG--------PLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYF---TGV 147 L+ KE + G L P+ + LR+ L L+ RP + TG Sbjct 54 LKLAKEADAILFGAVGDWKYDSLDRPLRP--EQAILGLRKHLQLFANFRPAICYPELTGA 111 Query 148 PSPVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETA 204 S PE V +++I RE + DIY G P G EA + F G +R+ E Sbjct 112 SS--LKPELVAGLDILIVRELNGDIYFG--QPRGVREAPDGL-FKGAREGFDTMRYSEPE 166 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 R+ A Q A + + V K N+++ F+ W K+ Sbjct 167 -----------VRRIAHVAFQAAAKRGK-KLCSVDKANVLE----TFQFW------KDI- 203 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 V + K + + + D Q++ P + VI T N+ GD +SD A Sbjct 204 ----------VIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFDVIVTGNMFGDILSDEAA 253 Query 325 AEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L ++ GL+E +HG+AP AG+ NP + ILSA MMLRY L E Sbjct 254 MLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPLATILSAAMMLRYSLNRAEQ 313 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 AD + ++ + T D + G K+V T + G+A++ Sbjct 314 ADRIENAVKKVLAQGYRTADI--VTPGCKQVGTREMGEAVL 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Chlorobium chlorochromatii CaD3] Sequence ID: Q3APC4.1 Length: 352 Range 1: 8 to 351 Score:92.8 bits(229), Expect:1e-19, Method:Compositional matrix adjust., Identities:103/398(26%), Positives:159/398(39%), Gaps:67/398(16%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ V+ +EK Y +IE E G + V+G+ L D TLEA Sbjct 8 IPGDGIGTEVVAGAVAVL-RQLEKKYGFTVEIE--EHLFGGASYDVHGE--MLTDATLEA 62 Query 102 IKEYQVAIKGPLTTPVGGGI------RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 K + G + P + + + +R++L L+ LRP + + + Sbjct 63 CKNCDAVLLGAVGGPKWENLPHEHKPEAALLKIRKELGLFANLRPAKVYDALVDASSLKA 122 Query 156 KV----NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPV 211 V + V+FRE + IY G P G + E G Sbjct 123 DVVRGTDFVVFRELTGGIYFG--QPRG---------------------YDENKGWNTMVY 159 Query 212 SKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 K R+ R A + A + V + K N+++ ++ Sbjct 160 EKYEVERIARLAFE-AARQRQGRVMSIDKANVLEVSQ----------------------- 195 Query 272 PWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGG 329 W V Q + + D+ D QI+ P ++ VI T NL GD +SD G Sbjct 196 LWRNVVHAVHADYQDVELSDMYVDNAAMQIVRNPKQFDVIVTGNLFGDILSDISGMITGS 255 Query 330 IGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQ 388 +G+ P A++ L+E HG+AP AGQ+K NP + I S MM + + A + Q Sbjct 256 LGMLPSASIGSKHALYEPIHGSAPDIAGQNKANPIATIASVAMMFEHSFKRTDIARDIEQ 315 Query 389 GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 IE A+ + T D A G VST+ +AII + Sbjct 316 AIEAALATGVRTADIA--AAGDTAVSTTAMTEAIISQL 351 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Leptospira interrogans serovar Lai str. 56601] Sequence ID: P24015.1 Length: 358 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130] Sequence ID: Q72RH7.1 Length: 358 Range 1: 4 to 354 Score:92.8 bits(229), Expect:1e-19, Method:Compositional matrix adjust., Identities:102/398(26%), Positives:179/398(44%), Gaps:61/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG ++ + +V+ A+ + + ++ E + G A G + LP ET Sbjct 4 VAVLSGDGIGPEVMEIAISVLKKALGAKVS---EFQFKEGFVGGIAIDKTG--HPLPPET 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGV--PS 149 L+ +E + G + P + R + LR+ DL+ LRP + + S Sbjct 59 LKLCEESSAILFGSVGGPKWETLPPEKQPERGALLPLRKHFDLFANLRPAIIYPELKNAS 118 Query 150 PVKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 PV++ ++++I RE + IY G P G + Q E +++ Sbjct 119 PVRSDIIGNGLDILILRELTGGIYFG--QPKGREGSG------QEEFAYDTMKY------ 164 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 S+ R+ + A Q A + + VT + K N++ T +K+ E+ KEF Sbjct 165 -----SRREIERIAKVAFQAARKRN-NKVTSIDKANVLT-TSVFWKEVVIELHKKEFSDV 217 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 L+ H++ D Q+++ P ++ V+ N+ GD +SD + Sbjct 218 QLN----HLY---------------VDNAAMQLIVNPKQFDVVLCENMFGDILSDEASII 258 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G IG+ P A+LS++ GL+E + G+AP AG+ NP + +LSA +MLRY +E A+ Sbjct 259 TGSIGMLPSASLSESGFGLYEPSGGSAPDIAGKGVANPIAQVLSAALMLRYSFSMEEEAN 318 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 + + I S T D A + G+ V T + G+ I Sbjct 319 KIETAVRKTIASGKRTRDIAEV--GSTIVGTKEIGQLI 354 >RecName: Full=3-isopropylmalate dehydrogenase 1, chloroplastic; Short=3-IPM-DH 1; Short=AtIMDH1; Short=IMDH 1; AltName: Full=Beta-IPM dehydrogenase 1; AltName: Full=Isopropylmalate dehydrogenase 1; Short=AtIMD1; AltName: Full=Methylthioalkylmalate dehydrogenase 1; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q9FMT1.1 Length: 409 Range 1: 49 to 401 Score:93.2 bits(230), Expect:2e-19, Method:Compositional matrix adjust., Identities:111/405(27%), Positives:173/405(42%), Gaps:69/405(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V KNV+ A S G + ++ E+ G A + G LP+ET Sbjct 49 IALLPGDGIGPEVISVAKNVLQKA--GSLEG-LEFDFKEMPVGGAALDLVGVP--LPEET 103 Query 99 LEAIKEYQVAIKGPLTTPVGGGIR--SLNVALRQQLDLYVCLRPVRYFTGV-PSPV---- 151 A K + G + GG + LR ++ L+ R ++ F + P+ V Sbjct 104 FTAAKLSDAILLGAI-----GGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQL 158 Query 152 --------KTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPET 203 + E V+M+I RE + IY G P + + NE G E Sbjct 159 VDASTLKKEVAEGVDMMIVRELTGGIYFG------EPRGITI-----NENG-------EE 200 Query 204 AGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEF 263 G+ + + R+ R A + A R + V K N++ A W V Sbjct 201 VGVSTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD----ASILWRKRVTA--- 252 Query 264 GAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDAL 323 E P + + + D Q++ P ++ I T N+ GD +SD Sbjct 253 ----------LASEYPD----VELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEA 298 Query 324 AAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKE 381 + G IG+ P A+L ++ GLFE HG+AP AGQDK NP + ILSA M+L+Y LG ++ Sbjct 299 SMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEK 358 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 AA + + A+ T D G K V + G+ ++K + Sbjct 359 AAKRIEDAVVDALNKGFRTGDI--YSPGNKLVGCKEMGEEVLKSV 401 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bordetella parapertussis 12822] Sequence ID: Q7W929.2 Length: 358 >RecName: Full=3-isopropylmalate dehydrogenase 2; AltName: Full=3-IPM-DH 2; AltName: Full=Beta-IPM dehydrogenase 2; Short=IMDH 2 [Bordetella bronchiseptica RB50] Sequence ID: Q7WKH4.1 Length: 358 Range 1: 5 to 357 Score:92.8 bits(229), Expect:2e-19, Method:Compositional matrix adjust., Identities:108/403(27%), Positives:168/403(41%), Gaps:65/403(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I + V+ A +E + G A + ++ LP T Sbjct 5 IAVLPGDGIGPEIVEQAERVLKAL-------DLPLELRQAPVGGAAFDQF--EHPLPPAT 55 Query 99 LEAIKEYQVAIKGPL------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 LE + + G + T P + LR+ L L+ LRP + + S Sbjct 56 LELAQGSHAVLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASS 115 Query 153 -TPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLIN---FLQNEMGVKKIRFPETAG 205 PE V +++I RE + DIY G +P V+ F G +R+ E+ Sbjct 116 LKPEIVSGLDILIIRELTGDIYFG------TPRGVRTAADGAFAGEREGYDTMRYAESE- 168 Query 206 IGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGA 265 R+ R + A ++ + V K N+++ T ++D EV+ Sbjct 169 ----------VRRIARIGFESARKRNKKLCS-VDKANVLE-TSQFWRDLVIEVS------ 210 Query 266 KPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 + + + + D Q++ P ++ VI T NL GD +SD A Sbjct 211 --------------RDYPDVELSHMYVDNAAMQLVRNPRQFDVIVTGNLFGDILSDEAAM 256 Query 326 EVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 G IG+ P A+L+ GL+E +HG+AP AGQ NP + ILSA M+LRY L A Sbjct 257 LTGSIGMLPSASLNAAGQGLYEPSHGSAPDIAGQGIANPLATILSAAMLLRYSLNLAPQA 316 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 D V + + T D G +VSTSQ G A++K + Sbjct 317 DRVEAAVRKVLADGLRTADIHE--AGTTKVSTSQMGDAVLKAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pelodictyon luteolum DSM 273] Sequence ID: Q3B595.1 Length: 353 Range 1: 7 to 351 Score:92.4 bits(228), Expect:2e-19, Method:Compositional matrix adjust., Identities:96/396(24%), Positives:162/396(40%), Gaps:62/396(15%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG ++ V+ + K + + ++E E G + ++G + L DETL A Sbjct 7 IPGDGIGPEVVAGALAVI-RQITKKHGFEIQVE--EHPFGGASYDLHG--SMLTDETLNA 61 Query 102 IKEYQVAIKGPLTTPVGGGI------RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPE 155 ++ + G + P + + + +R++L L+ LRP + + + Sbjct 62 CRDCDAVLLGAVGGPKWENLPHEHKPEAALLKIRRELGLFANLRPAKVYDALVDASSLKA 121 Query 156 KV----NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPV 211 V + ++FRE + IY G P G F E G Sbjct 122 DVVRGTDFMVFRELTGGIYFG--EPRG---------------------FDEKRGWNTMVY 158 Query 212 SKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 K R+ R A + A V + K N+++ ++ W EV Sbjct 159 EKHEVERIARLAFEAAQKRGSKRVMSIDKANVLEVSQF----WRNEV------------- 201 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 + + + D+ D QI+ P ++ VI T NL GD +SD G +G Sbjct 202 ----HRVHRDFPDVELSDMYVDNAAMQIVRNPKQFDVIVTGNLFGDILSDIAGMITGSLG 257 Query 332 IAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGI 390 + P A++ L+E HG+AP AG++ NP + I S MM + + ++ + I Sbjct 258 MLPSASIGRVHALYEPIHGSAPDIAGKNIANPIATIASVAMMFEHSFCMADISNEIHAAI 317 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 EGA+ T D A G K VST++ + II+H+ Sbjct 318 EGALSEGLRTADIA--APGQKSVSTTEMTEGIIRHL 351 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bordetella pertussis Tohama I] Sequence ID: Q7VY73.1 Length: 358 Range 1: 5 to 357 Score:92.4 bits(228), Expect:2e-19, Method:Compositional matrix adjust., Identities:110/403(27%), Positives:172/403(42%), Gaps:65/403(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I + V+ A +E + G A + ++ LP T Sbjct 5 IAVLPGDGIGPEIVEQAERVLKAL-------DLPLELRQAPVGGAAFDQF--EHPLPPAT 55 Query 99 LEAIKEYQVAIKGPL------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVK 152 LE + + G + T P + LR+ L L+ LRP + + S Sbjct 56 LELAQGSHAVLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASS 115 Query 153 -TPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLIN---FLQNEMGVKKIRFPETAG 205 PE V +++I RE + DIY G +P V+ F G +R+ E+ Sbjct 116 LKPEIVSGLDILIIRELTGDIYFG------TPRGVRTAADGAFAGEREGYDTMRYAESE- 168 Query 206 IGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGA 265 R+ R + A ++ + V K N+++ T ++D EV+ +++ Sbjct 169 ----------VRRIARIGFESARKRNKKLCS-VDKANVLE-TSQFWRDLVIEVS-RDY-- 213 Query 266 KPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 LD + + + D Q++ P ++ VI T NL GD +SD A Sbjct 214 --LD---------------VELSHMYVDNAAMQLVRNPRQFDVIVTGNLFGDILSDEAAM 256 Query 326 EVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 G IG+ P A+L+ GL+E +HG+AP AGQ NP + ILSA M+LRY L A Sbjct 257 LTGSIGMLPSASLNAAGQGLYEPSHGSAPDIAGQGIANPLATILSAAMLLRYSLNLAPQA 316 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 D V + + T D G +VSTSQ G A++K + Sbjct 317 DRVEAAVRKVLADGLRTADIHE--AGTTKVSTSQMGDAVLKAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Cupriavidus pinatubonensis JMP134] Sequence ID: Q46YW0.1 Length: 355 Range 1: 3 to 352 Score:92.4 bits(228), Expect:2e-19, Method:Compositional matrix adjust., Identities:113/399(28%), Positives:171/399(42%), Gaps:63/399(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++A EK E G + G + LP+ T Sbjct 3 IAVLPGDGIGPEIVAEAVKVLNALDEK-------FEMETAPVGGAGYEAEG--HPLPENT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYF---TGVPS 149 L+ KE + G + + R+L + LR+ L L+ RP + TG S Sbjct 54 LKLAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASS 113 Query 150 PVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 PE V +++I RE + DIY G P G EA + F G +R+ E Sbjct 114 --LKPELVAGLDILIVRELNGDIYFG--QPRGVREAPDGL-FKGAREGFDTMRYSEPE-- 166 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ A Q A + + V K N+++ F+ W K+ Sbjct 167 ---------IRRIAHVAFQAAAKRGKKLCS-VDKANVLE----TFQFW------KDI--- 203 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V + K + + + D Q++ P + VI T N+ GD +SD A Sbjct 204 --------VIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFDVIVTGNMFGDILSDEAAML 255 Query 327 VGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G IG+ P A+L ++ GL+E +HG+AP AG+ NP + ILSA MMLRY L E AD Sbjct 256 TGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPLATILSAAMMLRYSLNKAEQAD 315 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + ++ + T D L G K+V T + G+A++ Sbjct 316 RIENAVKKVLAQGYRTGDI--LTPGCKQVGTREMGEAVL 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Hydrogenovibrio crunogenus XCL-2] Sequence ID: Q31HI0.1 Length: 357 Range 1: 5 to 354 Score:92.4 bits(228), Expect:2e-19, Method:Compositional matrix adjust., Identities:108/401(27%), Positives:177/401(44%), Gaps:67/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG +I V++A +K I G A +G L +ET Sbjct 5 VLILPGDGIGPEITAEAVKVLEALQQKD---NLDISMTHDLVGGAAYDQHGVP--LAEET 59 Query 99 LEAIKEYQVAIKGPLTTPVGG-GIRSLNV---------ALRQQLDLYVCLRPVRYFTGVP 148 LE K+ + G VGG SL++ ALR L+L+ LRP F + Sbjct 60 LEKAKQSDAILLGA----VGGYQWESLDISVRPEKGLLALRSNLELFANLRPAYLFPQLA 115 Query 149 -SPVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETA 204 + PE V +++I RE + IY G P G++ + E Sbjct 116 DASTLKPEVVAGLDILIVRELTGGIYFG------QPR------------GIRTLDNGERQ 157 Query 205 GIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 G S+ R+ A A+ ++ + V K N+++ TE +++ EVA KE+ Sbjct 158 GYNTYVYSESEIKRIAHVAFDAAMKRNKKLCS-VDKANVLEVTE-MWREIVDEVA-KEY- 213 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 ++ ++ + D Q++L P ++ V+ T N+ GD +SD + Sbjct 214 ------------------PEVEVQHMYVDNAAMQLVLNPKQFDVMVTGNMFGDILSDEAS 255 Query 325 AEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ A+L ++ G++E +HG+AP AGQ+ NP + ILSA MMLRY L ++ Sbjct 256 MLTGSIGMLASASLDANNKGMYEPSHGSAPDIAGQNIANPLATILSAAMMLRYSLNREDL 315 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 A + + ++ T D G +VSTS+ G A++ Sbjct 316 ALKIETAVSKVLDQGLRTGDIWS--EGLTKVSTSEMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Streptococcus thermophilus CNRZ1066] Sequence ID: Q5LZF3.2 Length: 345 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Streptococcus thermophilus LMG 18311] Sequence ID: Q5M405.2 Length: 345 Range 1: 8 to 345 Score:92.4 bits(228), Expect:2e-19, Method:Compositional matrix adjust., Identities:105/396(27%), Positives:168/396(42%), Gaps:69/396(17%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 + GDGIG +I V+D A K + ++ + + + LP TLEA Sbjct 8 LSGDGIGPEIMAAGLGVLD-----KVASKIEFDYDVDAKPFGGAGIDAEGHPLPKATLEA 62 Query 102 IKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVP--SPVKTPE 155 K AI GP +A+R++L+L+ +RPVR F + SP+K PE Sbjct 63 AKSADAILLAAIGGPKYDNAPVRPEQGLLAIRKELNLFANIRPVRIFDALKHLSPLK-PE 121 Query 156 K---VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 + V+ V+ RE + IY G E I S Sbjct 122 RIEGVDFVVVRELTGGIYFGEHI------------------------LEEDKARDINDYS 157 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 + R++RRA + A + VT + K N++ T ++ EV++ EF Sbjct 158 ADEIRRIMRRAFKIAQGRGK-KVTSIDKQNVLA-TSKLWRKVADEVSL-EF--------- 205 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 +T++ + D+ ++ PA + V+ T NL GD +SD + G +G+ Sbjct 206 ----------PDVTLEHQLVDSAAMIMITNPARFDVVVTENLFGDILSDESSVLPGTLGV 255 Query 333 APGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR-YLGWKEAADLVVQGI 390 P A+ S+ L+E HG+AP AGQ NP S+ILS MMLR E A+L+ + Sbjct 256 MPSASHSENGPSLYEPIHGSAPDIAGQGIANPISMILSVAMMLRESFNETEGAELIENAV 315 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + +T D + ST++ AII ++ Sbjct 316 DKTLNQGILTRDL------GGQASTAEMTAAIISNL 345 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Oleidesulfovibrio alaskensis G20] Sequence ID: Q30WD0.1 Length: 358 Range 1: 5 to 325 Score:92.0 bits(227), Expect:2e-19, Method:Compositional matrix adjust., Identities:106/372(28%), Positives:164/372(44%), Gaps:66/372(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGK--RKIEWMEIYAGEKATKVYGKDNWLPD 96 I + GDGIG +I M+ V V ++ AGK +E+ + G A G + LP Sbjct 5 ICLLAGDGIGPEI---MEQGVR--VLETVAGKFGHDMEFTDALIGGAAIDETG--DPLPQ 57 Query 97 ETLEAIKEYQV----AIKGPLTTPVGGGIR--SLNVALRQQLDLYVCLRPVRYFTGVPS- 149 ET+EA K Q A+ GP + G R + + +R+ L L+ LRP + F + S Sbjct 58 ETVEACKAAQAVLLGAVGGPRWDNLTGAERPEAGLLGIRKALGLFANLRPAKLFPELASA 117 Query 150 ----PVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAG 205 P +++++ RE + IY G PAG ++ R Sbjct 118 CFLRPDIVANGIDVMVVRELTGGIYFGT--PAG-----------------EETRDGLRTA 158 Query 206 IGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGA 265 ++E R+ R A + A V V K N++ + + W V Sbjct 159 FNTMVYNEEEVRRIARVAFEAA-RKRSGRVCSVDKANVLAVS----RLWREIVTAT---- 209 Query 266 KPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 H E P + + + D Q++ P+++ VI T NL GD +SD + Sbjct 210 --------HADEFPD----VELSHMYVDNAAMQLVRDPSQFDVIVTGNLFGDILSDEASV 257 Query 326 EVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 G IG+ P A+L + GLFE HG+AP AGQ+K NP + ILS MMLR+ G ++ A Sbjct 258 ITGSIGMLPSASLGAGGPGLFEPIHGSAPDIAGQNKANPLATILSTAMMLRHSFGLEKEA 317 Query 384 DLVVQGIEGAIE 395 + +EGA++ Sbjct 318 ----EAVEGAVQ 325 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Neisseria meningitidis Z2491] Sequence ID: Q9JU79.1 Length: 356 Range 1: 5 to 353 Score:92.0 bits(227), Expect:2e-19, Method:Compositional matrix adjust., Identities:101/399(25%), Positives:173/399(43%), Gaps:64/399(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+D + + + + G +A YG + P+ T Sbjct 5 IAILRGDGIGPEIVAETVRVLDKLIAQGL----DVGYEYAPLGGEAYDEYG--HPYPEFT 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRPVRYFTGVPSPVK 152 ++ + G + +P + R L +A+R+ L+L+ LRP + + + Sbjct 59 QNLCRKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAILYPELANAST 118 Query 153 TPEKV----NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 ++ +++I RE + DIY G P ++++ + E G +++ E+ Sbjct 119 LKSEIVAGLDILIVRELTGDIYFG------EPRGIRVLENGERE-GYNTMKYSESE---- 167 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 R+ A Q A + V V K N+++ TE Sbjct 168 -------IRRIAHVAFQSAQKRSK-KVCSVGKANVLETTE-------------------- 199 Query 269 DGGPWH-VFEN-PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 W +FE K + + + D Q++ P ++ VIAT N+ GD +SD + Sbjct 200 ---LWREIFEEIGKEYPDVELSHMYVDNAAMQLVRAPKQFDVIATGNIFGDILSDEASML 256 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEA-AD 384 G IG+ P A+L + GL+E +HG+AP AGQ+K NP + +LS M+LRY EA A Sbjct 257 TGSIGMLPSASLDENGKGLYEPSHGSAPDIAGQNKANPLATVLSLAMLLRYSLNDEARAQ 316 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 V ++ ++ T D G K VS S+ G A++ Sbjct 317 QVENAVQKVLQQGLRTGDIYE--EGTKLVSCSEMGDAVL 353 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Sulfurimonas denitrificans DSM 1251] Sequence ID: Q30RK2.1 Length: 355 Range 1: 6 to 352 Score:91.7 bits(226), Expect:3e-19, Method:Compositional matrix adjust., Identities:106/406(26%), Positives:168/406(41%), Gaps:78/406(19%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I I+GDGIG +I V+DA + + + E G A + G + LP ET Sbjct 6 IALIKGDGIGPEIIDEAVKVLDAV---ASCCDLEFSYEEALMGGCAYDITG--DPLPQET 60 Query 99 LEAIKEYQVAIKGPL-----------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGV 147 + + G + P G +R R++L +Y LRP F + Sbjct 61 INISLNSDAVLFGAIGGAKWDNLPREKRPESGLLR-----FRKELGVYANLRPANVFDEL 115 Query 148 --PSPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPET 203 S +K + V++++ RE IY G P G E Sbjct 116 INASSLKAEVIKGVDLMVVRELIGGIYFG--EPKGRDE---------------------N 152 Query 204 AGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEF 263 G ++E R+ +A + A+ + V + K N++ ++ Sbjct 153 RGWNTMVYTREEIVRIAHQAFKIAMSRSK-RVCSIDKANVLDVSQ--------------- 196 Query 264 GAKPLDGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISD 321 W V E K ++ + + D Q++ P ++ V+ T N+ GD +SD Sbjct 197 --------LWREVVIEVAKEYPEVELTHMYVDNAAMQLIRDPRQFDVMLTGNIFGDILSD 248 Query 322 ALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWK 380 + G IG+ P A++ +G++E HG+AP AGQ NP + ILSA MMLRY LG Sbjct 249 EASMLSGSIGLLPSASVGAKIGVYEPIHGSAPDIAGQGIANPIATILSASMMLRYALGEH 308 Query 381 EAADLVVQGIEGAIESKTVTYDFARLMTGAKEV-STSQFGKAIIKH 425 AAD + ++ A++ T D A+ AKEV STS+ G I + Sbjct 309 GAADKIDAAVKRALKEGYRTKDLAQY--DAKEVCSTSEMGSIIANY 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Saccharophagus degradans 2-40] Sequence ID: Q21IY5.1 Length: 357 Range 1: 5 to 357 Score:91.7 bits(226), Expect:3e-19, Method:Compositional matrix adjust., Identities:110/400(28%), Positives:173/400(43%), Gaps:59/400(14%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I K V++A K G +++ E G A V+G L T Sbjct 5 IVLLPGDGIGPEIVAEAKKVLEAVDAKFKLG---LKFEEDLIGGCAIDVHGVP--LAQST 59 Query 99 LEAIKEYQVAIKGPLTTP----VGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 L+ K + G + P + IR + +R ++ LY LRP + Y + Sbjct 60 LDRCKAADAVLMGSVGGPKWDALDSNIRPEKGLLKIRYEMGLYANLRPAILYPQLADASS 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G P ++L++ E G Sbjct 120 LKPEIVSGLDILIVRELTGGIYFG------EPRGIRLLDN------------GERQGYNT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 ++ R+ R A + A+ D+ V V K N+++ T V +E Sbjct 162 YVYAEHEIERIGRTAFEMAMKRDK-KVCSVDKANVLEAT----------VLWREV----- 205 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 + K ++ + + D Q++ P ++ V+ T N+ GD +SD A G Sbjct 206 ------IQSISKDYPEVELSHMYVDNAAMQLVRAPKQFDVVVTGNMFGDILSDTAAMLTG 259 Query 329 GIGIAPGANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 IG+ P A+L+ D+ GL+E HG+AP AGQ NP + ILSA MMLRY L AAD + Sbjct 260 SIGMLPSASLNQDSKGLYEPVHGSAPDIAGQGVANPLATILSAAMMLRYSLNEAAAADAI 319 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + D G K+VST + G A+ I Sbjct 320 EAAVGAVLDDGLRSADI--FSEGMKKVSTQEMGDAVAAKI 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Gluconobacter oxydans 621H] Sequence ID: Q5FUG5.1 Length: 369 Range 1: 10 to 365 Score:91.7 bits(226), Expect:3e-19, Method:Compositional matrix adjust., Identities:103/402(26%), Positives:168/402(41%), Gaps:63/402(15%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 + GDGIG + VM+ V S K+E E G + V+G + DE +E Sbjct 10 LAGDGIGPE---VMREVARIVHWMSAHRGLKLEITEELVGAASLAVHGVP--IRDEVIEL 64 Query 102 IKEYQVAIKGPLTTPVGGGI---RSLNVA---LRQQLDLYVCLRPVRYFTG-VPSPVKTP 154 ++ + G + P + + VA LR++L+L+ LRP + F + + P Sbjct 65 ARQSDAVLFGSVGDPAWSHVGFDKRPEVAILKLRKELELFANLRPAKLFDALIDASALKP 124 Query 155 EKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPV 211 E V +++I RE IY G G++ + GI + Sbjct 125 EVVRGLDLMIVRETVGGIYFG------------------EPRGIETLPDGSRRGINTEVY 166 Query 212 SKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 + R+ R A A D + V V K N+M+ + +K+ +V +E+ Sbjct 167 TTSEIERVARVAFDLARKRD-NRVCSVEKCNVME-SGLLWKEVVTDVHKREY-------- 216 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 + + ++AD Q++ P ++ VI T NL GD +SD + G +G Sbjct 217 -----------PDVQLSHMLADNCAMQLVRDPNQFDVIVTGNLFGDILSDLASMLTGSLG 265 Query 332 IAPGANLSDTVG------LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 + P A L L+E HG+AP AG+ NP + ILS M+LRY L E AD Sbjct 266 MLPSATLGPVRADGKRNALYEPIHGSAPDIAGKGIANPLAQILSFAMLLRYSLNRAEDAD 325 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 L+ + + S T D + G V T G+A+++ + Sbjct 326 LIEMAVSNVLASGLRTGDI--MSPGMARVGTEMMGQAVLREM 365 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Prochlorococcus marinus str. MIT 9313] Sequence ID: Q7V842.1 Length: 357 Range 1: 6 to 357 Score:91.3 bits(225), Expect:5e-19, Method:Compositional matrix adjust., Identities:104/401(26%), Positives:177/401(44%), Gaps:62/401(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V K ++DA + + K E I G A G + LP T Sbjct 6 IVLLPGDGIGPEITAVAKLLLDA-LGHQHGFKLNFEQHPI--GGVAIDASG--SPLPAST 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGI------RSLNVALRQQLDLYVCLRPVRYFTGV--PSP 150 LEA + + + +P + + ++LR L L+ LRPV + S Sbjct 61 LEACQASDAVLLAAIGSPRFDALPREQRPETGLLSLRAGLKLFANLRPVTILPALIDASS 120 Query 151 VKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 +K + V++++ RE + IY G P G EA +E + + Sbjct 121 LKANVIKGVDLMVVRELTGGIYFG--QPKGRIEADG------DERAFNTMTY-------- 164 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 S+ R+ + A + A D + V K N++ ++ ++D + +G Sbjct 165 ---SRTEVDRIAKVAFELARDRS-GKLCSVDKANVLDVSQ-LWRDR-VDALAANYG---- 214 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 + + + D Q++ P ++ V+ T NL GD +SD A G Sbjct 215 ---------------DVELSHMYVDNAAMQLVRNPRQFDVLLTGNLFGDILSDEAAMLTG 259 Query 329 GIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLVV 387 IG+ P A+L S+ GLFE HG+AP AGQD NP +++L A MMLR +G KE + Sbjct 260 SIGMLPSASLGSEGPGLFEPVHGSAPDIAGQDLANPMAMVLCAAMMLR-IGLKE--NDAA 316 Query 388 QGIEGAIESKTVT-YDFARLMT-GAKEVSTSQFGKAIIKHI 426 + +EG++E + LM+ G ++ ++ G+ +++ + Sbjct 317 RALEGSVERVLAAGFRTGDLMSEGCTQLGCAEMGEQLLQAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Ralstonia pseudosolanacearum GMI1000] Sequence ID: Q8XXX5.2 Length: 356 Range 1: 46 to 353 Score:90.9 bits(224), Expect:6e-19, Method:Compositional matrix adjust., Identities:97/349(28%), Positives:153/349(43%), Gaps:56/349(16%) Query 90 KDNWLPDETLEAIKEYQVAIKGPL------TTPVGGGIRSLNVALRQQLDLYVCLRP-VR 142 K + LP++TL+ KE + G + T P + LR+ L L+ RP + Sbjct 46 KGHPLPEDTLKLAKEADAILFGAVGDWKYDTLPRELRPEQAILGLRKHLQLFANFRPAIC 105 Query 143 YFTGVPSPVKTPEKV---NMVIFRENSEDIYAGIEWPAG---SPEAVKLINFLQNEMGVK 196 Y + PE V +++I RE + DIY G P G +P+ + F G Sbjct 106 YPELAGASSMKPEIVAGLDILIVRELTGDIYFG--QPRGVRAAPDGL----FAGAREGFD 159 Query 197 KIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGY 256 +R+ E R+ A Q A + + V K N+++ F+ W Sbjct 160 TMRYSEPE-----------IRRIAHVAFQAAAKRGKKLCS-VDKANVLE----TFQFW-- 201 Query 257 EVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNG 316 K+ V + K ++ + + D Q++ P + V+ T N+ G Sbjct 202 ----KDI-----------VTDVHKEYPEVELSHMYVDNAAMQLVKAPKNFDVVVTGNMFG 246 Query 317 DYISDALAAEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR 375 D +SD A G IG+ P A+L ++ GL+E +HG+AP AG+ NP + ILSA MMLR Sbjct 247 DILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATILSAAMMLR 306 Query 376 Y-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 Y LG E AD + ++ + T D L G K+V T + G A++ Sbjct 307 YTLGKAEQADRIENAVKKVLAQGYRTGDI--LTPGCKQVGTVEMGDAVV 353 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Photobacterium profundum SS9] Sequence ID: Q6LV25.1 Length: 362 Range 1: 7 to 359 Score:90.9 bits(224), Expect:7e-19, Method:Compositional matrix adjust., Identities:103/402(26%), Positives:180/402(44%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA EK +E E G A +G LP+ T Sbjct 7 IAVLPGDGIGPEVMLQAHKVLDAVEEKF---GFTLERSEHDVGGIAIDNHGCP--LPEST 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 ++ +E + G + P + R + LR+ L+ LRP + +G+ S Sbjct 62 MKGCEESDAILFGSVGGPKWEHLAPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEGFS 121 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + ++V+ RE + IY G P G ++ P+ Sbjct 122 PLRADISERGFDIVVVRELTGGIYFG--QPKG-----------------REGEGPQEKAY 162 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + + R+ R A + A+ +++ V + K N+++ + + +E Sbjct 163 DTEIYHRYEIERIARIAFESAMLREKN-VYSIDKANVLQSS----------ILWREV--- 208 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V E K ++T+ + D Q++ P+++ V+ N+ GD ISD A Sbjct 209 --------VEEVAKDYPEVTLNHMYIDNATMQLIKDPSQFDVMLCSNIFGDIISDECAMI 260 Query 327 VGGIGIAPGANLS-DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L+ + G++E G+AP AG++ NP + ILSA +MLRY L ++AA Sbjct 261 TGSMGMLPSASLNQEKFGMYEPAGGSAPDIAGKNIANPVAQILSAALMLRYSLDEEKAAR 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + Q + A+E+ +T D A GA +STS+ G I +I Sbjct 321 AIEQAVSQALEAGELTADLAG--KGAA-LSTSEMGDKIAAYI 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Synechococcus sp. JA-3-3Ab] Sequence ID: Q2JTN8.1 Length: 381 Range 1: 13 to 365 Score:90.9 bits(224), Expect:7e-19, Method:Compositional matrix adjust., Identities:112/401(28%), Positives:171/401(42%), Gaps:61/401(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDA-AVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDE 97 I + GDGIG +I V + V+DA A + ++ ++W E G A + G + LP E Sbjct 13 ITALAGDGIGPEIMQVGRAVLDAVAAQVGFS----LQWQEGLIGGAAYEATG--DPLPPE 66 Query 98 TLEAIKEYQVAIKGPL------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTG-VPSP 150 TL+ +E + T P + LR L L+ LRPV+ F V + Sbjct 67 TLKMAQESDAVYLAAVGDFKYDTLPREKRPERALLGLRAGLGLFANLRPVKIFPQLVQAS 126 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V ++V+ RE + IY G P G + G ++ G+ Sbjct 127 SLKPEVVAGIDLVVVRELTGGIYFG--QPKG---------IFTDAKGSRR-------GVN 168 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S+ R+ R A + A R + V K N+++ ++ W V Sbjct 169 TMAYSEAEVDRIARVAFELA-RKRRRKLCSVDKANVLEVSQ----LWRERVTA------- 216 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 E P + + + D Q++ P ++ VI T NL GD +SD A Sbjct 217 ------IAAEYPD----VELSHLYVDNAAMQLVRWPKQFDVILTENLFGDILSDEAAMLT 266 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L S G++E HG+AP AGQDK NP + +LS M+LRY L +AAD Sbjct 267 GSIGMLPSASLGSSGPGVYEPVHGSAPDIAGQDKANPIAQVLSGAMLLRYSLDQPQAADR 326 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + Q +E + T D G V + G+ I+ + Sbjct 327 IEQAVEAVLAQGYRTADI--YSEGMTLVGCREMGEKILAAL 365 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Rhodospirillum rubrum ATCC 11170] Sequence ID: Q2RV53.1 Length: 370 Range 1: 7 to 365 Score:90.9 bits(224), Expect:8e-19, Method:Compositional matrix adjust., Identities:110/411(27%), Positives:169/411(41%), Gaps:75/411(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I F+ GDGIG ++ ++ V+D + G+ E + G A G L D+T Sbjct 7 ILFLAGDGIGPEVMAQVRRVMDWL---NQTGRTAFEVEDALVGGAAYDAQGTP--LHDDT 61 Query 99 LEAIKEYQVA----IKGPL--------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTG 146 + + GP P G +R LR+ L+L+ LRP F Sbjct 62 VALALAADAVLLGAVGGPKWDASLPFELKPERGLLR-----LRKDLELFANLRPAMVFDA 116 Query 147 VP--SPVKTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPE 202 + S +KT ++++I RE + +Y G G+ + E Sbjct 117 LAEASTLKTELVSGLDVMIVRELTGGVYFG------------------QPRGISALPNGE 158 Query 203 TAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 G+ + R+ + A A + + V K N+M+ G W EV + Sbjct 159 RRGVNTQVYDTHEIVRVAKVAFDLAGKRGK-RLCSVEKANVME--SGLL--WREEVT--K 211 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 GA + P+ I + + AD Q++ +P ++ VI T NL GD +SD Sbjct 212 LGA-----------DYPE----IALSHMYADNCAMQLVRQPKQFDVIVTDNLFGDILSDC 256 Query 323 LAAEVGGIGIAPGANL--SDTVG----LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 A G +G+ P A+L +D G ++E HG+AP AGQDK NP + ILS MMLRY Sbjct 257 AAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQDKANPLATILSFSMMLRY 316 Query 377 -LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 E ADLV + G + T D G V T+ G A++ + Sbjct 317 SFDLAEEADLVDNAVRGVLAKGLRTGDI--FQPGKTLVGTTGMGDALLAEM 365 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Synechococcus sp. CC9605] Sequence ID: Q3AIH4.1 Length: 357 Range 1: 8 to 312 Score:90.5 bits(223), Expect:9e-19, Method:Compositional matrix adjust., Identities:96/355(27%), Positives:156/355(43%), Gaps:64/355(18%) Query 41 FIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLE 100 + GDGIG +I V + +++ V + + E I G A G+ LP TL+ Sbjct 8 LLPGDGIGPEITAVARQLLEV-VSRRHGFSLSFEEQPI--GGSAIDATGEP--LPASTLD 62 Query 101 AIKEYQVAIKGPLTTPVGGGI------RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 A K + + +P + + + LR ++L+ LRPV+ VP+ + Sbjct 63 ACKAADAVLLAAIGSPCFDSLPREKRPETGLLGLRAGMELFANLRPVKI---VPALIDAS 119 Query 155 -------EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 E V++++ RE + IY G P G I +E G + + Sbjct 120 SLKREVIEGVDLMVVRELTGGIYFG--QPKGR------IETEGDERGFNTMTY------- 164 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S R+ + A + A + R + V K N++ ++ ++D +A Sbjct 165 ----SASEVDRIAKVAFEIAQER-RGRLCSVDKANVLDVSQ-LWRDRVDAMA-------- 210 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 P G + + + D Q++ P ++ V+ T NL GD +SD A Sbjct 211 -----------PSYG-PVEVSHMYVDNAAMQLVRDPRQFDVLLTGNLFGDILSDEAAMLT 258 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE 381 G IG+ P A+L S+ GLFE HG+AP AGQDK NP +++LSA MMLR +G K+ Sbjct 259 GSIGMLPSASLGSEGPGLFEPVHGSAPDIAGQDKANPMAMVLSAAMMLR-IGLKQ 312 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539] Sequence ID: Q9RTH9.1 Length: 352 Range 1: 2 to 345 Score:90.1 bits(222), Expect:1e-18, Method:Compositional matrix adjust., Identities:110/415(27%), Positives:169/415(40%), Gaps:96/415(23%) Query 37 PIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPD 96 P + + GDGIG ++ V+ + A +E I G A +G+ P Sbjct 2 PKVITLPGDGIGPEVTAAAVQVL-----REVAPDVTVEEHAIGGG--AYDAHGEP--FPT 52 Query 97 ETLEAIKEYQVAIKGPLTTPVGGGI--------RSLN-----VALRQQLDLYVCLRPVRY 143 T +A+KE + G VGG R L +ALR+ L Y LRPVR Sbjct 53 STRDALKEADAVLLGT----VGGAHDSAWNQLPRHLRPESGLLALRKALGCYANLRPVRV 108 Query 144 FTGVP--SPVKT--PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEM-GVKKI 198 G+ SP+K V+++I RE IY + A + + +E+ V K+ Sbjct 109 QPGLEHLSPLKAELARGVDILIVRELLGGIYFDQDRKIEGDTAYNTMRYTTSEVERVAKV 168 Query 199 RFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTE------GAFK 252 F +A + + VT V K N+++ +E A + Sbjct 169 AF-------------------------WAAEQRKGRVTSVDKANVLEVSELWRRDVQALR 203 Query 253 DWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATL 312 D Y + I + D+ I+ P+ Y VI T Sbjct 204 DRDY--------------------------RSIHLNHEYVDSVAMLIVADPSRYDVILTE 237 Query 313 NLNGDYISDALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEM 372 NL GD +SD A G +G+ P A+L D GLFE HG+AP AGQ NP + I+S M Sbjct 238 NLFGDILSDLAAVIPGSLGLMPSASLGDGAGLFEPIHGSAPDIAGQGVANPAAAIMSVGM 297 Query 373 MLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 +LR+ L EAA+ V + + A+ + R + G+ + T F +A++K + Sbjct 298 LLRHGLERSEAANQVDRAVALALREQPT-----RDLGGSADTQT--FTRAVLKAL 345 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Colwellia psychrerythraea 34H] Sequence ID: Q47WG3.1 Length: 362 Range 1: 4 to 359 Score:90.1 bits(222), Expect:1e-18, Method:Compositional matrix adjust., Identities:104/402(26%), Positives:161/402(40%), Gaps:60/402(14%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ K V++ K +I + G A +G N LPD T Sbjct 4 IAILAGDGIGPEVMVEAKKVLNTVASKF---DFEITTQDYDIGGAAIDNHG--NALPDST 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPSPV 151 + E + G + P + R + LR DL+ +RP + S Sbjct 59 MAGCIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLS 118 Query 152 K-----TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 + + ++++ RE + DIY G P G ++ E G Sbjct 119 TLRSDISEQGFDVLVIRELTGDIYFG--EPKG-----------------RRGEGEEETGF 159 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 S+ R+ A Q A + VT V K N++ T ++ EVAV Sbjct 160 DSMFYSRREVKRISHLAFQ-AAQKRNNKVTSVDKANVLA-TSQLWRQVVEEVAV------ 211 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E P + ++ + D Q++ P ++ V+ NL GD +SD A Sbjct 212 ----------EYPD----VELEHLYVDNAAMQLVRDPNQFDVMLCPNLFGDILSDICAMI 257 Query 327 VGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L SD G++E G+AP AG NP + ILSA +MLRY L AA Sbjct 258 TGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSAALMLRYSLNQGAAAK 317 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + A+++ +T D STS+ G I K I Sbjct 318 AIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQI 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Helicobacter hepaticus ATCC 51449] Sequence ID: Q7VH33.2 Length: 357 Range 1: 5 to 357 Score:89.7 bits(221), Expect:2e-18, Method:Compositional matrix adjust., Identities:104/406(26%), Positives:177/406(43%), Gaps:70/406(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I I GDGIG ++ ++ A V K Y + + E+ AG A G+ LP ++ Sbjct 5 IAVIYGDGIGKEVITQALKILKA-VAKKY--EHTFIFEEVLAGGAAIDECGE--CLPMKS 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN------VALRQQLDLYVCLRPVRYFTGVP--SP 150 L+ K+ + G + P S N + LR++L L+ +RP + SP Sbjct 60 LQICKQSDSVLLGAVGGPKWDNEPSHNRPEKALLTLRKELGLFANIRPATLLPQLSKASP 119 Query 151 VKTP---EKVNMVIFRENSEDIYAG---IEWPAGSPEAVKLINFLQNEM-GVKKIRFPET 203 +K ++ +I RE +Y G +E G A + + +++ + K+ F Sbjct 120 LKDEILNRGIDFIIVRELIGGVYFGEHKLEEINGEKVASDAMTYSASQIESIAKVAF--- 176 Query 204 AGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEF 263 + R N + + V K N++ + + W EV K Sbjct 177 --------------NIAR--------NRKKEIVCVDKANVLSSS----RLW-REVVDK-- 207 Query 264 GAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDAL 323 V +N K + + + D QI P+++ VI T N+ GD +SD Sbjct 208 -----------VAQNYK---DVHLSYMYVDNAAMQICRAPSQFDVILTENMFGDILSDEA 253 Query 324 AAEVGGIGIAPGANLSD-TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKE 381 + G IG+ P A+LS+ T+G++E HG+AP AGQDK NP ILSA MML G + Sbjct 254 SIITGTIGVIPSASLSNGTLGMYEPIHGSAPDIAGQDKANPIGTILSAAMMLELSFGLTK 313 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 ++++ + ++ A++ T D + G + V Q G I++ ++ Sbjct 314 ESEVIQKAVQNALDKGYRTGDM--MSEGMQLVGCEQMGDVILESVI 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Aliivibrio fischeri ES114] Sequence ID: Q5E857.1 Length: 363 Range 1: 8 to 361 Score:89.7 bits(221), Expect:2e-18, Method:Compositional matrix adjust., Identities:102/404(25%), Positives:181/404(44%), Gaps:65/404(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA +EK +A E ++ G A +G LP+ T Sbjct 8 IAVLPGDGIGPEVMEQAHKVLDA-IEKKHAISFSREQHDV--GGIAIDNHGCP--LPEST 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 ++ +E + G + P + R + LR+ L+ LRP + G+ S Sbjct 63 VKGCEESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHKGLENFS 122 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + ++V+ RE + IY G P G ++ P+ Sbjct 123 PLRADISERGFDIVVVRELTGGIYFG--QPKG-----------------REGEGPQEKAY 163 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + + R+ + A + A +++ V + K N+++ + + +E + Sbjct 164 DTEIYHRYEIERIAKIAFESARLRNKN-VYSIDKANVLQSS----------ILWREVVEE 212 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 G P +T+ + D Q++ P+++ V+ N+ GD ISD A Sbjct 213 VAKGYP-----------DVTLNHMYIDNATMQLIKDPSQFDVMLCSNIFGDIISDECAMI 261 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L+++ GL+E G+AP AG++ NP + ILSA +MLRY LG +EAA Sbjct 262 TGSMGMLPSASLNESNFGLYEPAGGSAPDIAGKNIANPVAQILSAALMLRYSLGEEEAAQ 321 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAK-EVSTSQFGKAIIKHIL 427 + + A+ + +T D A G K ++TS G I ++IL Sbjct 322 SIEAAVSKALSAGELTADLA----GDKPALTTSAMGDKIAEYIL 361 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Neisseria lactamica] Sequence ID: P50180.1 Length: 313 Range 1: 5 to 307 Score:88.6 bits(218), Expect:2e-18, Method:Compositional matrix adjust., Identities:94/350(27%), Positives:155/350(44%), Gaps:59/350(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+D +E+ + + G +A YG + P+ T Sbjct 5 IAILRGDGIGPEIVAETVRVLDKLIEQGLDAGYEYAPL----GGEAYDEYG--HPYPEFT 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRP-VRYFTGVPSPV 151 ++ + G + +P + R L +A+R+ L+L+ LRP V Y + Sbjct 59 QNLCRKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAVLYPELANAST 118 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + DIY G P ++++ + E G +++ E+ Sbjct 119 LKPEIVAGLDILIVRELTGDIYFG------EPRGIRVLENGERE-GYNTMKYSESE---- 167 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 R+ A Q A + V V K N+++ TE W Sbjct 168 -------IRRIAHVAFQSAQKRSK-KVCSVGKANVLETTEL----W-------------- 201 Query 269 DGGPWHVFEN-PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 +FE K + + + D Q++ P ++ VIAT N+ GD +SD + Sbjct 202 ----REIFEEIGKEYPDVELSHMYVDNAAMQLVRAPKQFDVIATGNIFGDILSDEASMLT 257 Query 328 GGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 G +G+ P A+L + GL+E +HG+AP AGQ+K NP + ILS M+LRY Sbjct 258 GSLGMLPSASLDENGKGLYEPSHGSAPDIAGQNKANPLATILSLAMLLRY 307 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Rhodococcus erythropolis PR4] Sequence ID: C0ZXM4.1 Length: 337 Range 1: 3 to 303 Score:88.6 bits(218), Expect:3e-18, Method:Compositional matrix adjust., Identities:98/351(28%), Positives:157/351(44%), Gaps:58/351(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + I GDGIG+++ V+ V +E E G + G+ LP + Sbjct 3 LAVIPGDGIGVEVTAEALKVLGKLVPD-------LETTEYDLGARRYNATGE--LLPADE 53 Query 99 LEAIKEYQVAIKGPLTTP--VGGGI--RSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTP 154 L+ I+++ + G + P V GI R L + +R QLD +V LRP + + G SP+ Sbjct 54 LDQIRQHDAILLGAIGDPRIVAPGILERGLLLNMRFQLDHHVNLRPAQLYPGALSPLAAQ 113 Query 155 EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKE 214 +++ V+ RE +E Y G G V + + E+ + + Sbjct 114 PEIDFVVVREGTEGPYTG----NGGAIRVGTDHEIATEVSIN---------------TWF 154 Query 215 GTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH 274 G R+VR A A + +TL+HK N++ GA + A++ GA+ D Sbjct 155 GAERVVRYAFALAQTRSK-HLTLIHKTNVLS-NAGAI----WTRAIETVGAEYPD----- 203 Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 + DA ++ P+ + VI T NL GD I+D A GGIG+A Sbjct 204 ----------VETAYCHIDAATIYMVTDPSRFDVIVTDNLFGDIITDLAGAVTGGIGLAA 253 Query 335 GANLSDTVG----LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE 381 N+ D G +FE HG+AP AG+ +P + ILSA ++LR+LG ++ Sbjct 254 SGNI-DASGTNPSMFEPVHGSAPDIAGKGIADPTAAILSAALLLRHLGRED 303 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bacillus cereus ATCC 14579] Sequence ID: Q81G11.1 Length: 354 Range 1: 5 to 344 Score:89.0 bits(219), Expect:3e-18, Method:Compositional matrix adjust., Identities:97/398(24%), Positives:174/398(43%), Gaps:68/398(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDG+G ++ K V+ VE+ Y + Y G A + G+ LP T Sbjct 5 IVCLAGDGVGPEVMESAKEVLHM-VERLYG--HHFHLQDEYFGGVAIDLTGQP--LPQRT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----VALRQQLDLYVCLRPV--RYFTGVPSPVK 152 L A + G + P + +ALR+ L ++ +RPV T SP+K Sbjct 60 LAACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLK 119 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPE--AVKLINFLQNEMGVKKIRFPETAGIGIKP 210 ++++ V+ RE + IY +P E A + + ++E+ Sbjct 120 NADEIDFVVVRELTGGIY--FSYPKERTEEVATDTLTYHRHEI----------------- 160 Query 211 VSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDG 270 R+V A Q A + + VT + K N+++ ++ ++ EVA++ Sbjct 161 ------ERIVSYAFQLA-NKRKKKVTSIDKANVLESSK-LWRTVTEEVALR--------- 203 Query 271 GPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGI 330 + N + ++ ++ DA +++ P + VI T NL GD +SD + G + Sbjct 204 -----YPN------VEVEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSL 252 Query 331 GIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMML-RYLGWKEAADLVVQ 388 G+ P A+ ++ L+E HG+AP AG++K NP +++ S MML + G + + Sbjct 253 GMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGYAIEE 312 Query 389 GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++S T D G E +TS F KA+I+ + Sbjct 313 AVSAVLKSGKCTADI-----GGTETTTS-FTKAVIQEM 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Syntrophotalea carbinolica DSM 2380] Sequence ID: Q3A3B2.1 Length: 365 Range 1: 7 to 363 Score:89.0 bits(219), Expect:3e-18, Method:Compositional matrix adjust., Identities:97/403(24%), Positives:170/403(42%), Gaps:60/403(14%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG +I V+DA VE+ + ++ + +A + LPD T Sbjct 7 LAVLPGDGIGPEIMAEAMKVLDA-VEQKF----QVRFERQFANVGGAAIDRDGKALPDAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPSPV 151 +E + + G + P + R + LR+ L+ LRP F + S Sbjct 62 VEICQASDAILFGSVGGPKWDTLPAEERPERGALLPLRRIFGLFCNLRPAIVFPALTSAS 121 Query 152 KTPEKV-----NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 E+V ++++ RE + IY P G ++ E G ++ G Sbjct 122 SLKEEVIAGGFDILVVRELTGGIY--FAQPKG----------VEGEGGERR-------GF 162 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + R+ R A A + V+ + K N++ + W EV + Sbjct 163 DTMAYTDAEVERITRVAFDAARKRGKKLVS-IDKANVLSTS----VLW-REVVERVSADY 216 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 P + + + D Q++ P ++ V+ N+ GD +SD A Sbjct 217 P----------------DVVLSHMYVDNAAMQLVKAPKQFDVLLCPNMFGDILSDEAAML 260 Query 327 VGGIGIAPGANLSD-TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ + G++E G+AP AG++ NP + ILSA M+LRY G +AAD Sbjct 261 TGSLGMLPSASLAEGSFGMYEPAGGSAPDIAGKNIANPVAQILSAAMLLRYSCGLADAAD 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 V + +E + + T D + G + VSTS G A++ ++ Sbjct 321 AVEKAVENCLAAGLRTGDIYQDADGEQLVSTSAMGDAVVAELI 363 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Vibrio vulnificus YJ016] Sequence ID: Q7MP78.1 Length: 363 Range 1: 8 to 361 Score:89.0 bits(219), Expect:3e-18, Method:Compositional matrix adjust., Identities:106/407(26%), Positives:175/407(42%), Gaps:71/407(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA +EK +A + E ++ G A +G LP T Sbjct 8 IAVLPGDGIGPEVMAQAHKVLDA-IEKKHAIHFEREEHDV--GGIAIDNHGCP--LPQST 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 + A +E + G + P + R + LR+ L+ LRP + +G+ S Sbjct 63 VTACEESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEAFS 122 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + ++V+ RE + IY G P G E G Sbjct 123 PLRADISGRGFDIVVVRELTGGIYFG--QPKGR----------------------EGEGA 158 Query 207 GIKPVSKEGTSRL-VRRAIQYAIDN---DRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 K E R + R + A ++ R V + K N+++ + + +E Sbjct 159 NEKAYDTEIYHRFEIERIAKIAFESARLRRKKVCSIDKANVLQSS----------ILWRE 208 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 V E K + + + D Q++ PA++ V+ N+ GD ISD Sbjct 209 V-----------VEEIAKDYPDVELSHMYIDNATMQLIKDPAQFDVMLCSNIFGDIISDE 257 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE 381 A G +G+ P A+L+++ GL+E G+AP AG++ NP + ILSA +MLRY +E Sbjct 258 CAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNIANPVAQILSAALMLRYSLGEE 317 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAK-EVSTSQFGKAIIKHIL 427 AA Q IE A+ + + G K +ST++ G I ++IL Sbjct 318 AA---AQDIENAVSQALAAGELTADLAGDKPALSTAEMGDKIAQYIL 361 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Vibrio vulnificus CMCP6] Sequence ID: Q8DEE0.1 Length: 363 Range 1: 8 to 361 Score:88.6 bits(218), Expect:4e-18, Method:Compositional matrix adjust., Identities:106/407(26%), Positives:175/407(42%), Gaps:71/407(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA +EK +A + E ++ G A +G LP T Sbjct 8 IAVLPGDGIGPEVMAQAHKVLDA-IEKKHAIHFEREEHDV--GGIAIDNHGCP--LPQST 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 + A +E + G + P + R + LR+ L+ LRP + +G+ S Sbjct 63 VTACEESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEAFS 122 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + ++V+ RE + IY G P G E G Sbjct 123 PLRADISGRGFDIVVVRELTGGIYFG--QPKGR----------------------EGEGA 158 Query 207 GIKPVSKEGTSRL-VRRAIQYAIDN---DRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 K E R + R + A ++ R V + K N+++ + + +E Sbjct 159 NEKAYDTEIYHRFEIERIAKIAFESARLRRKKVCSIDKANVLQSS----------ILWRE 208 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 V E K + + + D Q++ PA++ V+ N+ GD ISD Sbjct 209 V-----------VEELAKDYPDVELSHMYIDNATMQLIKDPAQFDVMLCSNIFGDIISDE 257 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKE 381 A G +G+ P A+L+++ GL+E G+AP AG++ NP + ILSA +MLRY +E Sbjct 258 CAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNIANPVAQILSAALMLRYSLGEE 317 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAK-EVSTSQFGKAIIKHIL 427 AA Q IE A+ + + G K +ST++ G I ++IL Sbjct 318 AA---AQDIENAVSQALAAGELTADLAGDKPALSTAEMGDKIAQYIL 361 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Vibrio cholerae O1 biovar El Tor str. N16961] Sequence ID: Q9KP82.1 Length: 363 Range 1: 8 to 361 Score:88.2 bits(217), Expect:5e-18, Method:Compositional matrix adjust., Identities:105/408(26%), Positives:177/408(43%), Gaps:73/408(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA +E+ + + E ++ G A +G LP+ T Sbjct 8 IAVLPGDGIGPEVMAQAHKVLDA-IEQKHGIRFSREEHDV--GGIAIDNHGCP--LPEST 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 L A +E + G + P + R + LR+ L+ LRP + G+ S Sbjct 63 LRACEEADAVLFGSVGGPKWEHLPPNEQPERGALLPLRKHFQLFCNLRPAQIHQGLEAFS 122 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + ++V+ RE + IY G P G E G Sbjct 123 PLRADISARGFDIVVVRELTGGIYFG--QPKGR----------------------EGEGA 158 Query 207 GIKPVSKEGTSRL-VRRAIQYAIDN---DRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 K E R + R + A ++ R V + K N+++ + + +E Sbjct 159 HEKAFDTEVYHRFEIERIARIAFESARLRRKKVCSIDKANVLQSS----------ILWRE 208 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 V E K +++ + D Q++ PA++ V+ N+ GD +SD Sbjct 209 V-----------VSEIAKEYPDVSLSHMYIDNATMQLIKDPAQFDVMLCSNIFGDILSDE 257 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWK 380 A G +G+ P A+++++ GL+E G+AP AG++ NP + ILSA +MLRY LG + Sbjct 258 CAMITGSMGMLPSASMNESKFGLYEPAGGSAPDIAGKNIANPVAQILSAALMLRYSLGEE 317 Query 381 EAADLVVQGIEGAIESKTVTYDFARLMTGAK-EVSTSQFGKAIIKHIL 427 AA + + A+ + +T D A G+K +STS G I +IL Sbjct 318 AAARDIENAVSQALAAGELTADLA----GSKPALSTSAMGDKIASYIL 361 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Nitrosomonas europaea ATCC 19718] Sequence ID: Q82WI6.1 Length: 356 Range 1: 90 to 353 Score:88.2 bits(217), Expect:5e-18, Method:Compositional matrix adjust., Identities:80/307(26%), Positives:137/307(44%), Gaps:49/307(15%) Query 126 VALRQQLDLYVCLRPVRYFTGVP-SPVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPE 181 +A+R++L+L+ LRPV + + + PE V +++I RE + DIY G P Sbjct 90 LAIRKELNLFANLRPVVLYPELSNASTLKPEVVAGLDILIVRELTGDIYFG------RPR 143 Query 182 AVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKG 241 ++ R + G S+ R+ A Q A + V K Sbjct 144 GIEY-------------RDGQKVGFNTMIYSESEIRRIAHVAFQ-AAGRRNGRLCSVDKM 189 Query 242 NIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILL 301 N+++ T+ ++D V E ++ +T+ ++ D Q++ Sbjct 190 NVLECTQ-LWRDV--------------------VTETAQSYPDVTLSHMLVDNAAMQLVR 228 Query 302 RPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD-TVGLFEATHGTAPKYAGQDK 360 P ++ V+ T N+ GD +SD + G IG+ P A+L D GL+E HG+AP AG+ Sbjct 229 NPRQFDVVVTGNMFGDILSDEASMLTGSIGMLPSASLDDRNKGLYEPIHGSAPDIAGKGI 288 Query 361 VNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFG 419 NP + ILSA MMLRY + AA + ++ ++ T D G K+V T + G Sbjct 289 ANPLATILSAAMMLRYSFNQETAASRIEHAVQKTLQQSYRTEDIYE--AGMKKVGTVEMG 346 Query 420 KAIIKHI 426 ++ ++ Sbjct 347 DRVLANL 353 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Frankia casuarinae] Sequence ID: Q2J6V8.1 Length: 342 Range 1: 6 to 300 Score:87.8 bits(216), Expect:5e-18, Method:Compositional matrix adjust., Identities:97/345(28%), Positives:145/345(42%), Gaps:58/345(16%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 I GDGIG VV + A K++ E G + G+ LPD LE Sbjct 6 IGGDGIG-------PEVVAEGLRVLRAVHPKVDTTEYDLGARRWHETGE--TLPDSVLEE 56 Query 102 IKEYQVAIKGPLTTP-VGGGIRSLNVALRQ--QLDLYVCLRPVRYFTGVPSPVKTPEKVN 158 ++ + + G + P V G+ + LR + D +V LRPVR + GV SP+ ++ Sbjct 57 LRGHDAILLGAVGDPGVPSGVLERGLLLRLRFEFDHHVNLRPVRLYPGVRSPLAGDPAID 116 Query 159 MVIFRENSEDIYAGIE--WPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGT 216 M++ RE +E YAG G+P V L GV+ Sbjct 117 MIVVREGTEGPYAGAGGVLRKGTPHEVATEESLNTRYGVE-------------------- 156 Query 217 SRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVF 276 R+VR A + A +R +TLVHK N++ + EVA EF Sbjct 157 -RVVRDAFRRADRRERRHLTLVHKNNVLTKAGDLWSRTVAEVA-PEF------------- 201 Query 277 ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGA 336 + + DA + P + V+ T N+ GD ++D AA GGIG+A Sbjct 202 ------PDVRVDYQHVDAASMFFVTDPGRFDVVVTDNMFGDILTDIGAAITGGIGLAASG 255 Query 337 NLSDT---VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLG 378 NL + +FE HG+AP AG+ +P + + S M+L +LG Sbjct 256 NLDPSGVHPSMFEPVHGSAPDIAGRQLADPTATVASVAMLLDHLG 300 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Nitrosococcus oceani ATCC 19707] Sequence ID: Q3JCC4.1 Length: 362 Range 1: 5 to 358 Score:88.2 bits(217), Expect:6e-18, Method:Compositional matrix adjust., Identities:107/401(27%), Positives:167/401(41%), Gaps:59/401(14%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ A E G+ + G A +V G LP ET Sbjct 5 IALLAGDGIGPEIIAEAVKVLAALGEH---GELDVVLESGLIGGAAYEVTGTP--LPAET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 L ++ A+ GP + +R + +R L L+ LRP + Y V + Sbjct 60 LALAQDSDAILLGAVGGPQWETLDIKVRPEKGLLGIRSALGLFANLRPAILYPQLVGAST 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G GV ++ E G Sbjct 120 LKPEVVSGLDLMIVRELTGGIYFG------------------QPRGVCRLEHGERQGFNT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 + R+ + A A+ DR V V K N+++ TE +++ EVA EF Sbjct 162 LVYKESEIRRIAQVAFTIAMKRDR-RVCSVDKANVLEATE-LWREVMSEVAA-EF----- 213 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 ++ + + D Q++ P ++ V+ T N+ GD +SD A G Sbjct 214 --------------PEVELSHMYVDNAAMQLVRAPKQFDVVVTTNMFGDILSDCAAMLTG 259 Query 329 GIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 IG+ P A+L + G++E HG+AP AGQ NP + ILS MMLRY L A + Sbjct 260 SIGMLPSASLDQSGRGMYEPIHGSAPDIAGQGIANPLATILSVAMMLRYSLDSPAQATRL 319 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 + + ++ T D G +VST G A+++ + Sbjct 320 EKAVGAVLDQGLRTPDIYS--PGTTQVSTGAMGDAVVEAFI 358 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Synechococcus sp. JA-2-3B'a(2-13)] Sequence ID: Q2JL30.1 Length: 371 Range 1: 13 to 344 Score:87.8 bits(216), Expect:8e-18, Method:Compositional matrix adjust., Identities:106/380(28%), Positives:161/380(42%), Gaps:63/380(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDA-AVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDE 97 I + GDGIG +I V + V+DA A + +A ++W E G A G + LP E Sbjct 13 ITALAGDGIGPEIMRVGRAVLDAVARQMGFA----LQWQEGLIGGAAYDQTG--DPLPAE 66 Query 98 TLEAIKEYQVAIKGPL------TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTG-VPSP 150 TL+ +E + P + LR L L+ LRPV+ F V + Sbjct 67 TLKMAQESDAVYLAAVGDFKYDALPPEKRPERALLGLRAGLGLFANLRPVKVFPQLVGAS 126 Query 151 VKTPE---KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE +++V+ RE + IY G P G + G ++ G+ Sbjct 127 SLKPEVIAGIDLVVVRELTGGIYFG--QPKG---------IFTDAQGSRR-------GVN 168 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S+ R+ R A + A R + V K N+++ ++ Sbjct 169 TMVYSEAEVDRIARVAFELA-RKRRRKLCSVDKANVLEVSQ------------------- 208 Query 268 LDGGPWHVFENPKTGQ--KITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 W N + ++ + + D Q++ P ++ VI T NL GD +SD A Sbjct 209 ----LWRERVNAIAAEYPEVELSHLYIDNAAMQLVRWPKQFDVILTGNLFGDILSDEAAM 264 Query 326 EVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 G IG+ P A+L S GL+E HG+AP AGQDK NP + +LS +MLRY L +AA Sbjct 265 LTGSIGMLPSASLGSSGPGLYEPVHGSAPDIAGQDKANPIAQVLSGALMLRYSLDQPQAA 324 Query 384 DLVVQGIEGAIESKTVTYDF 403 D + Q +E + T D Sbjct 325 DRIEQAVEAVLAQGYRTPDL 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bacillus anthracis] Sequence ID: Q81T67.1 Length: 354 Range 1: 5 to 344 Score:87.4 bits(215), Expect:9e-18, Method:Compositional matrix adjust., Identities:95/396(24%), Positives:168/396(42%), Gaps:64/396(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDG+G ++ K V+ VE+ Y + + G A + G+ LP T Sbjct 5 IVCLAGDGVGPEVMESAKEVLHM-VERLYG--HHFHLQDEHFGGVAIDLTGQP--LPQRT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----VALRQQLDLYVCLRPV--RYFTGVPSPVK 152 L A + G + P G + +ALR+ L ++ +RPV T SP+K Sbjct 60 LAACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLK 119 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 ++++ V+ RE + IY A + + ++E+ Sbjct 120 KADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEI------------------- 160 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 R+V A Q A + VT + K N+++ + K W + +E + D Sbjct 161 ----ERIVSCAFQLA-SKRKKKVTSIDKANVLESS----KLW--RIVTEEVALRYPD--- 206 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 + ++ ++ DA +++ P + VI T NL GD +SD + G +G+ Sbjct 207 ------------VELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGM 254 Query 333 APGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMML-RYLGWKEAADLVVQGI 390 P A+ ++ L+E HG+AP AG++K NP +++ S MML + G + + I Sbjct 255 LPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAI 314 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++S T D G E +TS F KA+++ + Sbjct 315 SAVLKSGKCTADI-----GGTETTTS-FTKAVMQEM 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Deinococcus geothermalis DSM 11300] Sequence ID: Q1IZK2.1 Length: 351 Range 1: 2 to 301 Score:87.4 bits(215), Expect:1e-17, Method:Compositional matrix adjust., Identities:102/355(29%), Positives:155/355(43%), Gaps:70/355(19%) Query 37 PIIPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPD 96 P + + GDGIG ++ A V + A IE I G A + +G + P Sbjct 2 PKVVTLPGDGIGPEV-----TAAAAEVLREVAPDVHIEEHAI--GGAAYEQFG--DPFPQ 52 Query 97 ETLEAIKEYQVAIKGPL----TTPVGGGIRSLN-----VALRQQLDLYVCLRPVRYFTGV 147 T +A+ + + G + +P R L +ALR+ L Y LRPVR G+ Sbjct 53 RTRDALGDADAVLLGTVGGAQNSPWNSLPRPLRPESGLLALRRALGCYANLRPVRVLPGL 112 Query 148 P--SPVKTPE---KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPE 202 SP+K PE V+++I RE IY G +KI + Sbjct 113 EHLSPLK-PELARGVDILIVRELLGGIYFD---------------------GDRKIEG-D 149 Query 203 TAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEV-AVK 261 TA ++ + E R+ R A +A + R VT V K N+++ +E W +V A++ Sbjct 150 TAYNTMRYTTPE-VERVARVAF-WAAEQRRGRVTSVDKANVLEVSE----LWRRDVQALR 203 Query 262 EFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISD 321 + + + + + D+ I+ P+ Y VI T NL GD +SD Sbjct 204 D-----------------REYRNVHLNHEYVDSVAMLIVANPSRYDVILTENLFGDILSD 246 Query 322 ALAAEVGGIGIAPGANLSDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 A G +G+ P A+L D GLFE HG+AP AGQ NP + I+S M+LR+ Sbjct 247 LAAVIPGSLGLMPSASLGDGPGLFEPIHGSAPDIAGQGIANPAAAIMSVAMLLRH 301 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Shewanella oneidensis MR-1] Sequence ID: Q8E9N3.1 Length: 364 Range 1: 5 to 356 Score:87.0 bits(214), Expect:1e-17, Method:Compositional matrix adjust., Identities:106/398(27%), Positives:172/398(43%), Gaps:60/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ + V+ A VE + IE+ E G A +G LP+ T Sbjct 5 IAVLAGDGIGPEVMAEARKVLKA-VEARFG--LNIEYTEYDVGGIAIDNHGCP--LPEAT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 L+ + + G + P + R + LR +L+ LRP + G+ S Sbjct 60 LKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMS 119 Query 150 PVKT---PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P+++ +++ RE + IY G P G ++E +R+ Sbjct 120 PLRSDISARGFDVLCVRELTGGIYFG--KPKGRQGEG------ESEEAFDTMRY------ 165 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 S+ SR+ R A + A R VT V K N++ + ++ EVAV Sbjct 166 -----SRREISRIARIAFE-AARGRRKKVTSVDKANVLACSV-LWRQVVEEVAVD----- 213 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 F + + ++ + D Q+L RP E+ V+ NL GD +SD +A Sbjct 214 ---------FPD------VELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAML 258 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ A+++ T GLFE G+AP AG+ NP + ILSA +MLR+ L +EAA Sbjct 259 TGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAAS 318 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 + + + A+ S +T + K +T Q G I Sbjct 319 AIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFI 356 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Hahella chejuensis KCTC 2396] Sequence ID: Q2SJD6.1 Length: 360 Range 1: 7 to 355 Score:86.7 bits(213), Expect:2e-17, Method:Compositional matrix adjust., Identities:108/396(27%), Positives:171/396(43%), Gaps:59/396(14%) Query 41 FIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLE 100 + GDGIG +I +NV+D K G + + E G A G P+ETL Sbjct 7 ILPGDGIGPEIVAQARNVLDVVNNKFSLG---LTFTEGLVGGAAIDTTGVP--FPEETLA 61 Query 101 AIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPVKT 153 + A+ GP + IR + LR L+L+ LRP + Y + Sbjct 62 TAEAADAILLGAVGGPKWDKLDMAIRPEKGLLGLRSGLELFANLRPAILYPQLAEASSLR 121 Query 154 PEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKP 210 PE V +++I RE + IY G GV+ + E G Sbjct 122 PEVVAGLDILIVRELTGGIYFG------------------KPRGVRTLENGEREGFNTYV 163 Query 211 VSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDG 270 S+ R+ R A + A ++ + V K N+++ T +++ E+A KE+ Sbjct 164 YSESEIRRIGRVAFEAAQKRNKRLCS-VDKANVLEVTV-LWREVMDELA-KEY------- 213 Query 271 GPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGI 330 + + + D Q++ P ++ VI T N+ GD +SD A G I Sbjct 214 ------------PDVELSHMYVDNAAMQLVRAPKQFDVIVTGNMFGDILSDEAAMLTGSI 261 Query 331 GIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQ 388 G+ P A+L+ G++E HG+AP AGQ+ NP + ILSA MMLRY L ++AA + Q Sbjct 262 GMLPSASLNAAGKGMYEPCHGSAPDIAGQNMANPLATILSAAMMLRYSLAAEDAAAAIEQ 321 Query 389 GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 + ++ T D A + + VST G+A+ + Sbjct 322 AVSDVLDQGLRTRDIAG--SSGESVSTQAMGEAVAR 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [[Bacillus thuringiensis] serovar konkukian str. 97-27] Sequence ID: Q6HLF2.1 Length: 354 Range 1: 5 to 344 Score:86.7 bits(213), Expect:2e-17, Method:Compositional matrix adjust., Identities:95/396(24%), Positives:167/396(42%), Gaps:64/396(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDG+G ++ K V+ VE+ Y + + G A + G+ LP T Sbjct 5 IVCLAGDGVGPEVMESAKGVLHM-VERLYG--HHFHLQDEHFGGVAIDLTGQP--LPQRT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----VALRQQLDLYVCLRPV--RYFTGVPSPVK 152 L A + G + P G + +ALR+ L ++ +RPV T SP+K Sbjct 60 LAACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLK 119 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 ++++ V+ RE + IY A + + ++E+ Sbjct 120 KADEIDFVVVRELTGGIYFSYPKKRTDEVATDTLTYHRHEI------------------- 160 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 R+V A Q A + VT + K N+++ + K W +E + D Sbjct 161 ----ERIVSYAFQLA-SKRKKKVTSIDKANVLESS----KLW--RTVTEEVALRYPD--- 206 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 + ++ ++ DA +++ P + VI T NL GD +SD + G +G+ Sbjct 207 ------------VELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGM 254 Query 333 APGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMML-RYLGWKEAADLVVQGI 390 P A+ ++ L+E HG+AP AG++K NP +++ S MML + G + + I Sbjct 255 LPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAI 314 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++S T D G E +TS F KA+++ + Sbjct 315 SAVLKSGKCTADI-----GGAETTTS-FTKAVMQEM 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Gloeobacter violaceus PCC 7421] Sequence ID: Q7NFH4.1 Length: 362 Range 1: 7 to 356 Score:86.3 bits(212), Expect:2e-17, Method:Compositional matrix adjust., Identities:117/402(29%), Positives:176/402(43%), Gaps:69/402(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEK-SYAGKRKIEWMEIYAGEKATKVYGKDNWLPDE 97 I + GDGIG +I V +++AA + +A ++ E G A G+ LP Sbjct 7 IAVLPGDGIGTEIVQVGVAMLEAAARRFDFA----FDFEEAPIGGAAIDATGEP--LPAA 60 Query 98 TLEAIKE----YQVAIKGPL--TTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTG-VPSP 150 TLE K + A+ GP T P + LR L L+ LRP R V + Sbjct 61 TLELCKASDAVFLGAVGGPQWDTLPSDKRPEKALLGLRAGLGLFANLRPARILPQLVAAS 120 Query 151 VKTPE---KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAG-- 205 PE V++++ RE + +Y GI P+ + FPE G Sbjct 121 ALKPEVVEGVDILVVRELTGGLYFGI------PKGI----------------FPEKKGGR 158 Query 206 IGIKPVSKEG--TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEF 263 G+ +S R+ R A + A + R + V K N+++ ++ W EV V Sbjct 159 RGVNTMSYSAFEIERIGRVAFEAARER-RGKLCSVDKANVLEVSQ----LW-REVLV--- 209 Query 264 GAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDAL 323 G P E P + + + D Q++ RP ++ I T N+ GD +SD Sbjct 210 GLAP---------EYPD----VELTHMYVDNCAMQLVRRPRQFDTIVTENMFGDILSDEA 256 Query 324 AAEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKE 381 A G IG+ P A+L S GL+E HG+AP AGQDK NP + +LS M+LR+ L E Sbjct 257 AMLTGSIGMLPSASLGSGGPGLYEPVHGSAPDIAGQDKANPLAQVLSGAMLLRHSLRQPE 316 Query 382 AADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 AA V + ++ +E T D A GA+ V G+ ++ Sbjct 317 AAQAVERAVQTVLEQGYRTGDIA--APGAQIVGCRAMGEQLL 356 >RecName: Full=3-isopropylmalate dehydrogenase 1; AltName: Full=3-IPM-DH 1; AltName: Full=Beta-IPM dehydrogenase 1; Short=IMDH 1 [Dechloromonas aromatica RCB] Sequence ID: Q47HR1.1 Length: 350 Range 1: 3 to 350 Score:86.3 bits(212), Expect:2e-17, Method:Compositional matrix adjust., Identities:103/401(26%), Positives:167/401(41%), Gaps:66/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+++ K E E G A G N P+ T Sbjct 3 ICVLPGDGIGPEITAQAVRVLNSL-------DLKFEMEEALLGGGAVDATG--NPYPEAT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRP-VRYFTGVPSP 150 + + + G + P + R L + +R+ L+L+ LRP + Y + Sbjct 54 QKLARAADAVLLGAVGGPKWDSLPREQRPERGL-LGIRKDLNLFANLRPAILYPELANAS 112 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V +++I RE + DIY G P V+ N E G Sbjct 113 TLKPEVVAGLDILIIRELTGDIYFG------QPRGVREEN-------------GERVGFN 153 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S+ R+ A Q A D+ + V K N+++ T+ ++D E++ Sbjct 154 TMVYSESEIRRIGHVAFQAAQKRDK-RLCSVDKMNVLECTQ-LWRDVMIEIS-------- 203 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 + + + ++ D Q++ P ++ V+ T N+ GD +SD + Sbjct 204 ------------RDYPDVELSHMLVDNAAMQLVKAPKQFDVMVTGNMFGDILSDEASMLT 251 Query 328 GGIGIAPGANLSD-TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L D GL+E +HG+AP AG+ NP + ILSA MMLRY G +E A Sbjct 252 GSIGMLPSASLDDKNKGLYEPSHGSAPDIAGKGVANPLATILSAAMMLRYTFGLEEQALR 311 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 V ++ + T D G +V T + G A++ + Sbjct 312 VENAVKKVLAQGYRTGDIYE--RGTNKVGTREMGDAVLAAL 350 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bacillus cereus E33L] Sequence ID: Q63DX7.1 Length: 354 Range 1: 5 to 344 Score:86.3 bits(212), Expect:3e-17, Method:Compositional matrix adjust., Identities:95/396(24%), Positives:167/396(42%), Gaps:64/396(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDG+G ++ K V+ VE+ Y + + G A + G+ LP T Sbjct 5 IVCLAGDGVGPEVMESAKEVLHM-VERLYG--HHFHLQDEHFGGVAIDLTGQP--LPQRT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----VALRQQLDLYVCLRPV--RYFTGVPSPVK 152 L A + G + P G + +ALR+ L ++ +RPV T SP+K Sbjct 60 LAACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESETAHLSPLK 119 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 ++++ V+ RE + IY A + + ++E+ Sbjct 120 KADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEI------------------- 160 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 R+V A Q A + VT + K N+++ + K W +E + D Sbjct 161 ----ERIVSYAFQLA-SKRKKKVTSIDKANVLESS----KLW--RTVTEEVALRYPD--- 206 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 + ++ ++ DA +++ P + VI T NL GD +SD + G +G+ Sbjct 207 ------------VELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGM 254 Query 333 APGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMML-RYLGWKEAADLVVQGI 390 P A+ ++ L+E HG+AP AG++K NP +++ S MML + G + + I Sbjct 255 LPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAI 314 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++S T D G E +TS F KA+++ + Sbjct 315 SAVLKSGKCTEDI-----GGTETTTS-FTKAVMQEM 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Sequence ID: P37412.2 Length: 363 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67] Sequence ID: Q57TE7.1 Length: 363 Range 1: 7 to 359 Score:86.3 bits(212), Expect:3e-17, Method:Compositional matrix adjust., Identities:102/402(25%), Positives:170/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA + +I G A +G + LP T Sbjct 7 IAVLPGDGIGPEVMAQALKVMDAVRSRF---DMRITTSHYDVGGIAIDNHG--HPLPKAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + + +E Sbjct 172 ---------IERIARIAFESA-RKRRRKVTSIDKANVLQSS----------ILWREI--- 208 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V + KT + + + D Q++ P+++ V+ NL GD +SD A Sbjct 209 --------VNDVAKTYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDANDAAT 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + Q I A+E T D AR GA VST + G I +++ Sbjct 321 AIEQAINRALEEGVRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Vibrio parahaemolyticus RIMD 2210633] Sequence ID: Q87SS8.1 Length: 363 Range 1: 8 to 361 Score:85.9 bits(211), Expect:3e-17, Method:Compositional matrix adjust., Identities:103/407(25%), Positives:176/407(43%), Gaps:71/407(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA +E+ + + E ++ G A +G LP+ T Sbjct 8 IAVLPGDGIGPEVMAQAHKVLDA-IEQKHGISFEREEHDV--GGIAIDNHGCP--LPEST 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 + A +E + G + P + R + LR+ L+ LRP + G+ S Sbjct 63 VTACEESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHAGLEAFS 122 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + ++V+ RE + IY G P G E G Sbjct 123 PLRADISGRGFDIVVVRELTGGIYFG--QPKGR----------------------EGEGA 158 Query 207 GIKPVSKEGTSRL-VRRAIQYAIDN---DRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 K E R + R + A ++ R V + K N+++ + + +E Sbjct 159 NEKAFDTEVYHRYEIERIAKIAFESARLRRKKVCSIDKANVLQSS----------ILWRE 208 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 V E K + + + D Q++ PA++ V+ N+ GD ISD Sbjct 209 V-----------VEEIAKDYPDVELSHMYIDNATMQLIKDPAQFDVMLCSNIFGDIISDE 257 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWK 380 A G +G+ P A+L+++ GL+E G+AP AG++ NP + ILSA +MLRY LG + Sbjct 258 CAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNIANPVAQILSAALMLRYSLGEE 317 Query 381 EAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 AA + + A+ + +T D A + ++TS+ G I ++IL Sbjct 318 AAAQDIESAVSKALSAGELTADLA---SDKPALTTSEMGDKIAEYIL 361 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudomonas aeruginosa PAO1] Sequence ID: Q51375.2 Length: 360 Range 1: 5 to 357 Score:85.9 bits(211), Expect:3e-17, Method:Compositional matrix adjust., Identities:105/401(26%), Positives:171/401(42%), Gaps:61/401(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++ A ++ G E E G A +G L D+T Sbjct 5 ILVLPGDGIGPEIMAEAVKVLELANDRFQLG---FELAEDVIGGAAIDKHGVP--LADQT 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 L+ ++ A+ GP + IR + +R QL L+ LRP + Y + Sbjct 60 LQRARQADAVLLGAVGGPKWDRIERDIRPERGLLKIRSQLGLFANLRPAILYPQLAAASS 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G P +++ E G E Sbjct 120 LKPEVVAGLDILIVRELTGGIYFG------QPREQRVL-----ENG-------ERQAYDT 161 Query 209 KPVSKEGTSRLVRRAIQYA-IDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 P S+ R+ R A + N+R + V K N++ ++ +++ EVA Sbjct 162 LPYSESEIRRIARVGFDMARVRNNR--LCSVDKANVLASSQ-LWREVVEEVA-------- 210 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 K + + + D Q++ P ++ V+ T N+ GD +SD + Sbjct 211 ------------KDYPDVELSHMYVDNAAMQLVRAPKQFDVMVTDNMFGDILSDEASMLT 258 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L ++ G++E HG+AP AGQ NP + ILS MMLRY AAD Sbjct 259 GSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGIANPLATILSVSMMLRYSFSQATAADA 318 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + Q + ++ T D G ++V T + G A++ + Sbjct 319 IEQAVSKVLDQGLRTGDI--WSEGCRKVGTREMGDAVVAAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Nitrosospira multiformis ATCC 25196] Sequence ID: Q2Y7Q8.1 Length: 353 Range 1: 3 to 353 Score:85.9 bits(211), Expect:3e-17, Method:Compositional matrix adjust., Identities:103/400(26%), Positives:169/400(42%), Gaps:61/400(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ E + K+E + G A G+ P T Sbjct 3 IAILAGDGIGPEIVAQAVRVL----ETLRSDGLKLELEQGLLGGCAVDAAGEP--FPAAT 56 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-RSLN-----VALRQQLDLYVCLRP-VRYFTGVPSPV 151 + + I G + P G+ R L + +R+ L+L+ LRP V Y + Sbjct 57 RTLVAQADAVILGAVGGPRYDGLPRQLRPEQGLLGIRKALNLFANLRPAVLYPELADAST 116 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + DIY G P ++L N +G + + E Sbjct 117 LKPEVVSGLDILIVRELTGDIYFG------EPRGIELRN--GQRIGYNTMIYSEAE---- 164 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 R+ R A Q A R + V K N+++ T+ ++D E A G P Sbjct 165 -------IRRIARVAFQAARKRSR-RLCSVDKMNVLESTQ-LWRDVVTETA----GEYP- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 + + ++ D Q++ P ++ V+ T N+ GD +SD + G Sbjct 211 ---------------DVELSHMLVDNAAMQLVRNPRQFDVVVTGNMFGDILSDEASMLTG 255 Query 329 GIGIAPGANLSD-TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 IG+ P A+L + GL+E HG+AP AG+D NP + +LS MMLRY +E A + Sbjct 256 SIGMLPSASLDERNKGLYEPIHGSAPDIAGKDVANPLATVLSVAMMLRYTFDREEEASRI 315 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + T D G ++ T+ G A++ + Sbjct 316 ERAVKKVLADGYRTADIYE--PGKMKIGTAAMGDAVLASL 353 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Staphylococcus epidermidis ATCC 12228] Sequence ID: Q8CNL2.1 Length: 347 Range 1: 8 to 329 Score:85.9 bits(211), Expect:3e-17, Method:Compositional matrix adjust., Identities:99/372(27%), Positives:155/372(41%), Gaps:60/372(16%) Query 42 IEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEA 101 + GDGIG +I ++ EK Y + +E G + YG L +ETL++ Sbjct 8 LPGDGIGPEILSGTLELLKLISEK-YHFEYHLESHHF--GGVSIDYYGTP--LTNETLQS 62 Query 102 IKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVP--SPVKTP- 154 K AI GP T + LR+ L+L+ +RP G SP+K Sbjct 63 CKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQDI 122 Query 155 -EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSK 213 E ++VI RE + IY G P VK +T + S Sbjct 123 VEGTDLVIVRELTSGIYFG------EPSYVK-----------------KTEALDSLKYSS 159 Query 214 EGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPW 273 + R+VR A A + R +T V K N++ + K W V Sbjct 160 QEIERIVRIAFNLA-NRRRKKLTSVDKENVL----SSSKLWRQIVN-------------- 200 Query 274 HVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIA 333 + K ++ + ++ DA ++ +P ++ VI T NL GD +SD + G +G++ Sbjct 201 ---DVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGDILSDEASVIPGSLGLS 257 Query 334 PGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR-YLGWKEAADLVVQGIE 391 P A+ T L+E HG+AP A +DK NP ++LS + LR L +AA+ + + Sbjct 258 PSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVLSLALCLRESLNQNDAANELESIVY 317 Query 392 GAIESKTVTYDF 403 I+S T D Sbjct 318 SFIQSNKTTADL 329 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150] Sequence ID: Q5PDG2.1 Length: 363 Range 1: 7 to 359 Score:85.9 bits(211), Expect:3e-17, Method:Compositional matrix adjust., Identities:102/402(25%), Positives:170/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA + +I G A +G + LP T Sbjct 7 IAVLPGDGIGPEVMAQALKVMDAVRSRF---DMRITTSRYDVGGIAIDNHG--HPLPKAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + + +E Sbjct 172 ---------IERIARIAFESA-RKRRRKVTSIDKANVLQSS----------ILWREI--- 208 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V + KT + + + D Q++ P+++ V+ NL GD +SD A Sbjct 209 --------VNDVAKTYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDANDAAT 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + Q I A+E T D AR GA VST + G I +++ Sbjct 321 AIEQAINRALEEGVRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Escherichia coli O157:H7] Sequence ID: Q8X9Z9.3 Length: 363 Range 1: 7 to 359 Score:85.9 bits(211), Expect:3e-17, Method:Compositional matrix adjust., Identities:103/402(26%), Positives:174/402(43%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA V +A + ++ G A +G+ LP T Sbjct 7 IAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + +++ E+A Sbjct 172 ---------IERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT------ 214 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E P I + + D Q++ P+++ V+ NL GD +SD A Sbjct 215 ----------EYPD----IELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAS 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 321 AIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Salmonella enterica subsp. enterica serovar Typhi] Sequence ID: Q8Z9I1.1 Length: 363 Range 1: 7 to 359 Score:85.9 bits(211), Expect:4e-17, Method:Compositional matrix adjust., Identities:102/402(25%), Positives:169/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA + +I G A +G + LP T Sbjct 7 IAVLPGDGIGPEVMAQALKVMDAVRSRF---DMRITTSRYDVGGIAIDNHG--HPLPKAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + + +E Sbjct 172 ---------IERIARIAFESA-RKRRRKVTSIDKANVLQSS----------ILWREI--- 208 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V + K + + + D Q++ P+++ V+ NL GD +SD A Sbjct 209 --------VNDVAKAYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L EAA Sbjct 261 TGSMGMLPSASLNEQEFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADEAAT 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + Q I A+E T D AR GA VST + G I +++ Sbjct 321 AIEQAINRALEEGVRTSDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Staphylococcus epidermidis RP62A] Sequence ID: Q5HMF8.1 Length: 347 Range 1: 10 to 329 Score:85.5 bits(210), Expect:4e-17, Method:Compositional matrix adjust., Identities:99/370(27%), Positives:154/370(41%), Gaps:60/370(16%) Query 44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIK 103 GDGIG +I ++ EK Y + +E G + YG L +ETL++ K Sbjct 10 GDGIGPEILSGTLELLKLISEK-YHFEYHLESHHF--GGVSIDYYGTP--LTNETLQSCK 64 Query 104 EYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVP--SPVKTP--E 155 AI GP T + LR+ L+L+ +RP G SP+K E Sbjct 65 NADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQDIVE 124 Query 156 KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEG 215 ++VI RE + IY G P VK +T + S + Sbjct 125 GTDLVIVRELTSGIYFG------EPSYVK-----------------KTEALDSLKYSSQE 161 Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHV 275 R+VR A A + R +T V K N++ + K W V Sbjct 162 IERIVRIAFNLA-NRRRKKLTSVDKENVL----SSSKLWRQIVN---------------- 200 Query 276 FENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPG 335 + K ++ + ++ DA ++ +P ++ VI T NL GD +SD + G +G++P Sbjct 201 -DVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGDILSDEASVIPGSLGLSPS 259 Query 336 ANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR-YLGWKEAADLVVQGIEGA 393 A+ T L+E HG+AP A +DK NP ++LS + LR L +AA+ + + Sbjct 260 ASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVLSLALCLRESLNQNDAANELESIVYSF 319 Query 394 IESKTVTYDF 403 I+S T D Sbjct 320 IQSNKTTADL 329 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Shigella dysenteriae Sd197] Sequence ID: Q32K21.2 Length: 363 Range 1: 7 to 359 Score:85.5 bits(210), Expect:4e-17, Method:Compositional matrix adjust., Identities:102/402(25%), Positives:170/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA V +A + ++ G A +G+ LP T Sbjct 7 IAALPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ + A I Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV-YHRFEIERIARI 178 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + K R VT + K N+++ + + V E + Sbjct 179 AFESARKR-----------------RHKVTSIDKANVLQSS------ILWREIVNEIATE 215 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 D H++ + T Q IKD P+++ V+ NL GD +SD A Sbjct 216 YPDVELAHMYIDNATMQ--LIKD-------------PSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAS 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 321 AIERAINRALEEGIRTRDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Chromohalobacter salexigens DSM 3043] Sequence ID: Q1QUR0.2 Length: 359 Range 1: 5 to 353 Score:85.5 bits(210), Expect:5e-17, Method:Compositional matrix adjust., Identities:109/398(27%), Positives:166/398(41%), Gaps:62/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I +++A E + IE E G +G LPDET Sbjct 5 ILVLPGDGIGPEITREAVKILNACREAGL--EASIE--EGLVGGAGIDAHGVP--LPDET 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN-------VALRQQLDLYVCLRPVRYFTGVPSPV 151 L + K + G + P I L+ + LR+ L+L+ LRP + + S Sbjct 59 LASAKAADAVLLGAVGGPQWDKIEDLSKRPEKGLLGLRKNLNLFGNLRPALLYPQLASAS 118 Query 152 K-TPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V +++I RE + IY G P G E R E G Sbjct 119 SLKPEIVAGLDIMIVRELTGGIYFG--QPRGIEE-----------------RDGERVGYN 159 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 ++ R+ R A + A + + V K N+++ T W EV + P Sbjct 160 TYIYAEHEIERIGRVAFEMARERG-GKLCSVDKANVLEAT----ILW-REVMERLAPEYP 213 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 + + + D Q++ P ++ VI T N+ GD +SDA A Sbjct 214 ----------------DVALSHMYVDNAAMQLVRAPKQFDVIVTGNMFGDILSDAAAMLT 257 Query 328 GGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 G IG+ P A+L++ G++E HG+AP AGQ NP + ILS MMLRY L + A+ Sbjct 258 GSIGMLPSASLNEQRQGMYEPCHGSAPDIAGQGIANPLATILSVAMMLRYSLEAPQLAER 317 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + + + ++ T D A G VST G A++ Sbjct 318 IERAVGTVLDQGLRTADIA--FEGTAPVSTQAMGDAVL 353 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Aromatoleum aromaticum EbN1] Sequence ID: Q5P1J6.1 Length: 350 Range 1: 3 to 350 Score:85.1 bits(209), Expect:5e-17, Method:Compositional matrix adjust., Identities:104/401(26%), Positives:170/401(42%), Gaps:66/401(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++A K E E G A G + P+ T Sbjct 3 ICILPGDGIGPEITAEAVRVIEAL-------DLKFEMEEALLGGAAVDATG--DPYPEAT 53 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPSPV 151 + +E + G + P + R L + +R+ L L+ LRP + + + Sbjct 54 RKLAREADAVLLGAVGGPKWDTLPREQRPERGL-LGIRKDLGLFANLRPAILYPELANAS 112 Query 152 K-TPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V +++I RE + DIY G P G ++R E G Sbjct 113 SLKPEVVAGLDILIVRELTGDIYFG--QPRG-----------------LEVRDGERFGFN 153 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 S+ R+ R A + A +R + V K N+++ T+ ++D E+A Sbjct 154 TMHYSESEIRRIGRVAFEAARKRNR-RLCSVDKMNVLETTQ-LWRDVMIELAA------- 204 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 E P + + ++ D Q++ P ++ V+ T N+ GD +SD + Sbjct 205 ---------EYPD----VELSHMLVDNAAMQLVRAPKQFDVMVTGNMFGDILSDEASMLT 251 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADLV 386 G IG+ P A+L ++ GL+E +HG+AP AGQ NP + ILS MMLRY +E L Sbjct 252 GSIGMLPSASLDANNKGLYEPSHGSAPDIAGQGIANPLATILSVAMMLRYTFNQENGALR 311 Query 387 VQ-GIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++ ++ + T D G +V T Q G A++ + Sbjct 312 IENAVKKVLAQGLRTGDI--FEPGTTKVGTKQMGDAVLAAL 350 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Escherichia coli UTI89] Sequence ID: Q1RGC4.1 Length: 364 Range 1: 8 to 360 Score:85.1 bits(209), Expect:6e-17, Method:Compositional matrix adjust., Identities:105/402(26%), Positives:173/402(43%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA V +A + ++ G A +G+ LP T Sbjct 8 IAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 63 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 122 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 123 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 172 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + + V E + Sbjct 173 ---------IERIARIAFESA-RKRRHKVTSIDKANVLQSS------ILWREIVNEIATE 216 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 D H++ + T Q IKD P+++ V+ NL GD +SD A Sbjct 217 YPDVELAHMYIDNATMQ--LIKD-------------PSQFDVLLCSNLFGDILSDECAMI 261 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 262 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAS 321 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 322 AIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 360 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Escherichia coli CFT073] Sequence ID: Q8FL76.3 Length: 363 Range 1: 7 to 359 Score:85.1 bits(209), Expect:6e-17, Method:Compositional matrix adjust., Identities:102/402(25%), Positives:174/402(43%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA V +A + ++ G A +G+ LP T Sbjct 7 IAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + +++ E+A Sbjct 172 ---------IERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT------ 214 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E P + + + D Q++ P+++ V+ NL GD +SD A Sbjct 215 ----------EYPD----VELTHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAS 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 321 AIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Nitratidesulfovibrio vulgaris str. Hildenborough] Sequence ID: Q726X1.1 Length: 357 Range 1: 5 to 307 Score:85.1 bits(209), Expect:6e-17, Method:Compositional matrix adjust., Identities:94/349(27%), Positives:141/349(40%), Gaps:58/349(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+DA + + G A G LPD T Sbjct 5 ICLLPGDGIGPEIVAQGTKVLDAVARRF---GHTVSTSSALIGGAAIDATGSP--LPDAT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN------VALRQQLDLYVCLRPVRYFTGVPSPVK 152 +EA + + G + P + S + +R+ L L+ LRP F + Sbjct 60 VEACRTSDAVLLGAVGGPKWDDLPSEKRPEKGLLGIRKALGLFANLRPAALFPELAGACL 119 Query 153 TPEKV-----NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 + ++V+ RE + D+Y G PAG ++ G++ G Sbjct 120 LRADIAAAGLDLVVVRELTGDVYFG--QPAG----------IETRDGLRT-------GFN 160 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 ++ R+ R A A R V V K N++ T +++ EVA Sbjct 161 TMIYDEDEVRRIARVAFDTARARKR-RVCSVDKANVLA-TSRLWREVVEEVA-------- 210 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 + + + + D Q++ PA++ VI T NL GD +SD A Sbjct 211 ------------RDYPDVELSHMYVDNAAMQLVRWPAQFDVIVTGNLFGDILSDEAAVIT 258 Query 328 GGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLR 375 G IG+ P A++ S LFE HG+AP AGQDK NP + ILS MMLR Sbjct 259 GSIGMLPSASMGSGGPALFEPIHGSAPDIAGQDKANPIATILSVGMMLR 307 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Nostoc sp. PCC 7120 = FACHB-418] Sequence ID: Q8YXA2.1 Length: 362 Range 1: 218 to 359 Score:85.1 bits(209), Expect:7e-17, Method:Compositional matrix adjust., Identities:53/144(37%), Positives:77/144(53%), Gaps:4/144(2%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-VG 343 + + + D Q++ P ++ I T NL GD +SDA A G IG+ P A+L + G Sbjct 218 VELSHLYVDNAAMQLVRAPKQFDTIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGPG 277 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 +FE HG+AP AGQDK NP + +LSA MMLRY L +AAD + Q + +E T D Sbjct 278 VFEPVHGSAPDIAGQDKANPLAQVLSAAMMLRYALDQPQAADKIEQAVLQVLEQGDRTGD 337 Query 403 FARLMTGAKEVSTSQFGKAIIKHI 426 + G + G ++IK + Sbjct 338 I--ISVGMNLLGCRGMGDSLIKAL 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Photorhabdus laumondii subsp. laumondii TTO1] Sequence ID: Q7N128.1 Length: 363 Range 1: 7 to 359 Score:84.7 bits(208), Expect:8e-17, Method:Compositional matrix adjust., Identities:103/402(26%), Positives:169/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ ++DA + K + I E G A +G LP +T Sbjct 7 IAVLPGDGIGPEVMAQAYKILDA-IRKRF--NICITTSEYDVGGIAIDRHGCS--LPAKT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTG--VPS 149 + ++ + G + P + R + LR+ L+ LRP R + G V Sbjct 62 VAGCEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYAGLEVFC 121 Query 150 PVKT---PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + +++ RE + IY G P G K E+ RF Sbjct 122 PLRNDIAAKGFDILCVRELTGGIYFG--QPKGREGQGKYERAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A + VT + K N+++ + V +E Sbjct 172 ---------IERIARIAFESA-RKRSNKVTSIDKANVLQSS----------VLWREV--- 208 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V E K + I + D Q++ P+++ V+ N+ GD +SD A Sbjct 209 --------VTEIAKAYPDVEINHMYIDNATMQLIKDPSQFDVMLCSNIFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG+ NP + ILSA ++LRY LG +AA+ Sbjct 261 TGSMGMLPSASLNEKGFGLYEPAGGSAPDIAGKGIANPIAQILSAALLLRYSLGHNDAAN 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + Q + A+E T D A K +ST + G I ++I Sbjct 321 AIEQAVNYALEQGYRTTDLA---GNGKAISTDEMGSTIARYI 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Escherichia coli K-12] Sequence ID: P30125.3 Length: 363 Range 1: 7 to 359 Score:84.3 bits(207), Expect:1e-16, Method:Compositional matrix adjust., Identities:102/402(25%), Positives:174/402(43%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA V +A + ++ G A +G+ LP T Sbjct 7 IAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + +++ E+A Sbjct 172 ---------IERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT------ 214 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E P + + + D Q++ P+++ V+ NL GD +SD A Sbjct 215 ----------EYPD----VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAC 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 321 AIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Psychrobacter cryohalolentis K5] Sequence ID: Q1QAF5.1 Length: 367 Range 1: 4 to 367 Score:84.3 bits(207), Expect:1e-16, Method:Compositional matrix adjust., Identities:108/409(26%), Positives:178/409(43%), Gaps:65/409(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I +V++A +K +A +E I G A G+ LP+ET Sbjct 4 ILTLAGDGIGPEIMTQAIDVLNAVNDK-FALGLTLESGLI--GGVAVDSTGEP--LPEET 58 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGV--PS 149 L+ + + G + P GI R L + +R +L L+ LR + + + S Sbjct 59 LQRARAADAVLLGAVGGPKWDGIERSKRPERGL-LKIRSELGLFANLRVAKLYPQLVNAS 117 Query 150 PVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 +K PE + +++I RE + IY G P G++ + E G Sbjct 118 SIK-PEIISGLDLLIVRELTGGIYFG------EPR------------GIRTLENGEQQGY 158 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDS-----VTLVHKGNIMKFTEGAFKDWGYEVAVK 261 S +R+ + A + A + + V + K N+++ TE +K E+ Sbjct 159 NTMVYSTSEINRIGKVAFELAQTRAQAAGTAAKVCSIDKANVLEVTE-LWKQTMIELQQS 217 Query 262 EFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISD 321 E+ + + + AD Q++ P ++ V+ T NL GD +SD Sbjct 218 EY-------------------SDVALSHMYADNACMQLIKDPKQFDVMVTGNLFGDILSD 258 Query 322 ALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGW 379 A G IG+ P A+L + G++E HG+AP AGQD NP + ILS MMLRY Sbjct 259 EAAMLTGSIGMLPSASLDEAGKGMYEPCHGSAPDIAGQDIANPLATILSVSMMLRYTFKQ 318 Query 380 KEAADLVVQGIEGAIESKTVTYD-FARLMTGAKEVSTSQFGKAIIKHIL 427 + AA + Q + ++ T D R G +V Q G+A++ ++ Sbjct 319 EAAAQAIEQAVSDVLDDGLRTVDILDRNEAGLIQVGCQQMGQAVLAKLI 367 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudomonas protegens Pf-5] Sequence ID: Q4KF05.1 Length: 360 Range 1: 5 to 354 Score:84.0 bits(206), Expect:1e-16, Method:Compositional matrix adjust., Identities:104/397(26%), Positives:165/397(41%), Gaps:59/397(14%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++ A +K G E G A +G L DET Sbjct 5 ILILPGDGIGPEIMAEAVKVLELANDKYSLG---FELSHDVIGGAAIDKHGVP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 L+ + A+ GP + IR + +R QL L+ LRP + Y + Sbjct 60 LDRARAADAVLLGAVGGPKWDKIERDIRPERGLLKIRAQLGLFGNLRPAILYPQLADASS 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G +P G +++ E Sbjct 120 LKPEIVSGLDILIVRELTGGIYFG------APR------------GTRELENGERQSYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ R A + + V K N++ ++ +++ +VA Sbjct 162 LPYSESEIRRIARVGFDMARVRGK-KLCSVDKANVLASSQ-LWREVVEQVA--------- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 K + + + D Q++ P ++ VI T N+ GD +SD + G Sbjct 211 -----------KDYPDVELSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDEASMLTG 259 Query 329 GIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 IG+ P A+L ++ G++E HG+AP AGQ NP + ILS MMLRY EAAD + Sbjct 260 SIGMLPSASLDANNKGMYEPCHGSAPDIAGQGIANPLATILSVSMMLRYSFNLTEAADAI 319 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 Q + ++ T D G +V T + G A++ Sbjct 320 EQAVSRVLDQGLRTGDI--WSAGCTKVGTQEMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Bacillus cereus ATCC 10987] Sequence ID: Q73B99.1 Length: 354 Range 1: 5 to 344 Score:84.0 bits(206), Expect:1e-16, Method:Compositional matrix adjust., Identities:94/396(24%), Positives:165/396(41%), Gaps:64/396(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDG+G ++ K V+ VE+ Y + Y G A + G+ LP T Sbjct 5 IVCLAGDGVGPEVMESAKEVLHM-VERLYG--HHFHLQDEYFGGSAIDLNGQP--LPQRT 59 Query 99 LEAIKEYQVAIKGPLTTPVGGGIRSLN----VALRQQLDLYVCLRPV--RYFTGVPSPVK 152 L A + G + P + +ALR+ L ++ +RPV T SP+K Sbjct 60 LAACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLK 119 Query 153 TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVS 212 ++++ V+ RE + IY A + + ++E+ Sbjct 120 KADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEI------------------- 160 Query 213 KEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP 272 R+V A Q A + VT + K N+++ + K W +E + D Sbjct 161 ----ERIVSYAFQLA-SKRKKKVTSIDKANVLESS----KLW--RTVTEEVALRYPD--- 206 Query 273 WHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGI 332 + ++ ++ DA +++ P + VI T NL GD +SD + G +G+ Sbjct 207 ------------VELEHILVDAAAMELIRNPGRFDVIVTENLFGDILSDEASVLAGSLGM 254 Query 333 APGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMML-RYLGWKEAADLVVQGI 390 P A+ ++ L+E HG+AP AG++K NP +++ S MML + G + + I Sbjct 255 LPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSFGLTREGCAIEEAI 314 Query 391 EGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++ T D G E +TS F KA+++ + Sbjct 315 SAVLKLGKCTADI-----GGTETTTS-FTKAVMQEM 344 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudomonas fluorescens Pf0-1] Sequence ID: Q3KF21.1 Length: 360 Range 1: 5 to 354 Score:83.2 bits(204), Expect:3e-16, Method:Compositional matrix adjust., Identities:103/397(26%), Positives:165/397(41%), Gaps:59/397(14%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++ A EK G E G A +G L DET Sbjct 5 ILILPGDGIGPEIMAEAVKVLELANEKYSLG---FELSHDVIGGAAIDKHGVP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 L+ + A+ GP + IR + +R QL L+ LRP + Y + Sbjct 60 LDRARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRAQLGLFGNLRPAILYPQLADASS 119 Query 152 KTPE---KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE ++++I RE + IY G +P G + + E Sbjct 120 LKPEIAAGLDILIVRELTGGIYFG------APR------------GTRTLENGERQSYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ R A + + V K N++ ++ +++ +VA Sbjct 162 LPYSESEIRRIARVGFDMARVRGK-KLCSVDKANVLASSQ-LWREVVEQVA--------- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 K + + + D Q++ P ++ VI T N+ GD +SD + G Sbjct 211 -----------KDYPDVELSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDEASMLTG 259 Query 329 GIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 IG+ P A+L ++ G++E HG+AP AG+ NP + ILS MMLRY EAAD + Sbjct 260 SIGMLPSASLDANNKGMYEPCHGSAPDIAGKGIANPLATILSVSMMLRYSFNLHEAADAI 319 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + + ++ T D TG +V T + G A++ Sbjct 320 EKAVSVVLDQGLRTGDI--FSTGCTKVGTQEMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Trichormus variabilis ATCC 29413] Sequence ID: Q3M8T9.1 Length: 362 Range 1: 218 to 359 Score:83.2 bits(204), Expect:3e-16, Method:Compositional matrix adjust., Identities:52/144(36%), Positives:76/144(52%), Gaps:4/144(2%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-VG 343 + + + D Q++ P ++ I T NL GD +SDA A G IG+ P A+L + G Sbjct 218 VELSHLYVDNAAMQLVRAPKQFDTIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGPG 277 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 +FE HG+AP AG DK NP + +LSA MMLRY L +AAD + Q + +E T D Sbjct 278 VFEPVHGSAPDIAGLDKANPLAQVLSAAMMLRYALNQPQAADKIEQAVLQVLEQGDRTGD 337 Query 403 FARLMTGAKEVSTSQFGKAIIKHI 426 + G + G ++IK + Sbjct 338 I--MSVGMNLLGCRAMGDSLIKAL 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Shigella boydii Sb227] Sequence ID: Q326G2.2 Length: 363 Range 1: 7 to 359 Score:82.8 bits(203), Expect:4e-16, Method:Compositional matrix adjust., Identities:101/402(25%), Positives:173/402(43%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA V +A + ++ G A +G+ LP T Sbjct 7 IAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + +++ E+A Sbjct 172 ---------IERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT------ 214 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E P + + + D Q++ P+++ V+ NL GD +SD A Sbjct 215 ----------EYPD----VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP G++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDITGKNIANPIAQILSLALLLRYSLDADDAAC 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 321 AIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Thermosynechococcus vestitus BP-1] Sequence ID: P59029.1 Length: 361 Range 1: 7 to 310 Score:82.8 bits(203), Expect:4e-16, Method:Compositional matrix adjust., Identities:97/354(27%), Positives:150/354(42%), Gaps:66/354(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V +V+ A + +++ G A G+ LP T Sbjct 7 IAVLAGDGIGPEITAVALDVLRAIAPRF---GLDFDFVPALVGGCAIDAVGEP--LPAAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-----RSLN-----VALRQQLDLYVCLRPVRYFTGV- 147 L ++ L +GG R L +ALR L L+ LRP + F + Sbjct 62 LATCRQSDAV----LLAAIGGTQWDSLPRHLRPETGLLALRSGLGLFANLRPAKIFPQLL 117 Query 148 -PSPVKTPE---KVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPET 203 S +K PE V++++ RE + IY G P G E G E Sbjct 118 HASSLK-PEVIAGVDLMVVRELTGGIYFG--QPRG---------IFTTETG-------EQ 158 Query 204 AGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEF 263 G+ + R+ R A + A + + V K N+++ ++ ++D ++ Sbjct 159 RGVNTMAYTATEIDRIGRVAFETA-RKRQGKLCSVDKANVLEVSQ-LWRDRLTALSA--- 213 Query 264 GAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDAL 323 E P + + + D Q++ P ++ I T NL GD +SD Sbjct 214 -------------EYPD----VELTHLYVDNAAMQLVRAPKQFDTIVTSNLFGDILSDIA 256 Query 324 AAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 A G IG+ P A+L ++ LFE HG+AP AGQDK NP +++LSA MMLRY Sbjct 257 AMLTGSIGMLPSASLGESGPALFEPVHGSAPDIAGQDKANPLAMVLSAAMMLRY 310 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Shigella sonnei Ss046] Sequence ID: Q3Z5T7.2 Length: 363 Range 1: 7 to 359 Score:82.4 bits(202), Expect:4e-16, Method:Compositional matrix adjust., Identities:104/402(26%), Positives:173/402(43%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V++A V +A + ++ G A +G+ LP T Sbjct 7 IAVLPGDGIGPEVMTQALKVLNA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR++ L+ LRP + + G+ + Sbjct 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKRFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N ++ RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + V E + Sbjct 172 ---------IERIARIAFESA-RKRRHKVTSIDKANVLQ------SSILWREIVNEIATE 215 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 D H++ + T Q IKD P+++ V+ NL GD +SD A Sbjct 216 YPDVELAHMYIDNATMQ--LIKD-------------PSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAC 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 321 AIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Shigella flexneri] Sequence ID: Q83SP1.3 Length: 363 Range 1: 7 to 359 Score:82.4 bits(202), Expect:5e-16, Method:Compositional matrix adjust., Identities:101/402(25%), Positives:173/402(43%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V++A V +A + ++ G A +G+ LP T Sbjct 7 IAVLPGDGIGPEVMTQALKVLNA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 +E ++ + G + P + R + LR+ L+ LRP + + G+ + Sbjct 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 Query 150 PVKTPEKVN---MVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ N + RE + IY G P G + + E+ RF Sbjct 122 PLRADIAANGFDIQCVRELTGGIYFG--QPKGREGSGQYEKAFDTEV---YHRFE----- 171 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 R+ R A + A R VT + K N+++ + +++ E+A Sbjct 172 ---------IERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT------ 214 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E P + + + D Q++ P+++ V+ NL GD +SD A Sbjct 215 ----------EYPD----VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG++ NP + ILS ++LRY L +AA Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAS 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + I A+E T D AR GA VST + G I +++ Sbjct 321 AIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Dehalococcoides mccartyi CBDB1] Sequence ID: Q3ZXI7.1 Length: 365 Range 1: 93 to 363 Score:82.0 bits(201), Expect:6e-16, Method:Compositional matrix adjust., Identities:80/320(25%), Positives:135/320(42%), Gaps:68/320(21%) Query 126 VALRQQLDLYVCLRPVRYFTGV--PSPVKTP--EKVNMVIFRENSEDIYAGI---EW--P 176 +ALR+ L L+ +RPV+ + +P+K + + + RE + +Y W P Sbjct 93 LALRKGLGLFANIRPVKVAPSLVNSTPIKAEIVKGTDFIFIRELTGGVYFAKPKKRWTTP 152 Query 177 AGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVT 236 AG +A + + +NE+ R+VR + A N + + Sbjct 153 AGIRKATDSMTYSENEI-----------------------ERIVRVGFELA-KNRKKKLV 188 Query 237 LVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWH--VFENPKTGQKITIKDVIADA 294 V K N++ L W V E K ++ ++ V+ DA Sbjct 189 SVDKANVL-----------------------LSSRLWRQIVIEVAKDYPEVKVEHVLVDA 225 Query 295 FLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL-------SDTVGLFEA 347 +++L P + VI T NL GD ++D + G +G+ P A+L + GL+E Sbjct 226 CAMKLILAPTYFDVIVTENLFGDILTDEASMLAGSMGMLPSASLAGIPAKGTKIFGLYEP 285 Query 348 THGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARL 406 HG+AP A Q+ NP + ILS MMLRY G + A + ++ + + T D + Sbjct 286 IHGSAPTIAKQNIANPIATILSIAMMLRYSCGLETEAVEIESAVDKVLAAGYATIDIFK- 344 Query 407 MTGAKEVSTSQFGKAIIKHI 426 G ++ T++ G I K I Sbjct 345 -EGNTKLGTAEMGNQITKMI 363 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [[Mannheimia] succiniciproducens MBEL55E] Sequence ID: Q65V05.1 Length: 358 Range 1: 6 to 358 Score:82.0 bits(201), Expect:6e-16, Method:Compositional matrix adjust., Identities:101/402(25%), Positives:163/402(40%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG ++ V+D V+ + K+ + + G A G+ LP ET Sbjct 6 VAVLPGDGIGPEVMAEAIKVLDK-VQAKFG--FKLNFTQYLVGGAAIDAKGEP--LPAET 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 L+ + G + P + R + LR+ L+ LRP + G+ Sbjct 61 LQGCDNADAILFGSVGGPKWTHLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFC 120 Query 150 PVKT---PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + +MV+ RE + IY G P G + +T Sbjct 121 PLRADIAAKGFDMVVVRELTGGIYFG--QPKG-----------------RDGEGSDTRAF 161 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + K R+ R A A+ R VT V K N+++ + W VA Sbjct 162 DTEVYYKYEIERIARAAFDAAMKR-RKQVTSVDKANVLQSS----ILWRETVA------- 209 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 E K ++ ++++ D Q++ P + V+ N+ GD ISD A Sbjct 210 ----------EIAKEYPEVQVENMYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMI 259 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG+ NP + ILSA MMLRY EAA Sbjct 260 TGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKGIANPIAQILSAAMMLRYSFNLNEAAT 319 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + ++ + T D A + VST++ G I I Sbjct 320 AIENAVQKVLADGHRTGDLA---DNSTPVSTAEMGTLIANAI 358 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pectobacterium atrosepticum SCRI1043] Sequence ID: Q6D0G7.1 Length: 363 Range 1: 7 to 359 Score:81.6 bits(200), Expect:9e-16, Method:Compositional matrix adjust., Identities:98/402(24%), Positives:170/402(42%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ V+DA ++ G R I E G A G LP T Sbjct 7 IAVLPGDGIGPEVMAQAHKVLDAVRQRF--GIR-ITTSEYDVGGIAIDRQGTP--LPQAT 61 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPS-- 149 + ++ + G + P + R + LR+ L+ LRP R + G+ + Sbjct 62 VAGCEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEAFC 121 Query 150 PVKT---PEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P+++ + +++ RE + IY G P G + + E+ + A I Sbjct 122 PLRSDIAAKGFDILCVRELTGGIYFG--QPKGREGSGQYERAFDTEV-YHRFEIERIAHI 178 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + K RR+I VT + K N+++ + + +E Sbjct 179 AFESARK-------RRSI----------VTSIDKANVLQSS----------ILWREI--- 208 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 V E K + + + D Q++ P+++ V+ NL GD +SD A Sbjct 209 --------VTEVAKAYPDVKLSHLYIDNATMQLIKDPSQFDVMLCSNLFGDILSDECAMI 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G +G+ P A+L++ GL+E G+AP AG+D NP + ILS ++LRY LG +AA+ Sbjct 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKDIANPIAQILSLALLLRYSLGADDAAE 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + + A+ T D A + + + TS+ G I + + Sbjct 321 AIEKAVNTALAEGYRTADLA---SASNAIGTSEMGDVIARFV 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudoalteromonas translucida TAC125] Sequence ID: Q3IJS3.1 Length: 358 Range 1: 8 to 319 Score:81.3 bits(199), Expect:1e-15, Method:Compositional matrix adjust., Identities:97/360(27%), Positives:155/360(43%), Gaps:63/360(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG +I + V+DA V + E I G A +GK LP T Sbjct 8 VAVLAGDGIGPEIMAAAEQVLDA-VSNKFGFTLNREHHAI--GGAAIDKHGK--ALPQST 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 + A + + G + P + R + LR+ L+ LRP + + S Sbjct 63 VTACENADAILFGAVGGPKWEHLPPDEQPERGSLLPLRKHFGLFCNLRPAQLLPALSTAS 122 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + + +++ RE + IY G + +G E NE R+ Sbjct 123 PLRADISEQGFDILCVRELTGGIYFGEKGRSGEGE---------NESAFDTQRY------ 167 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDS-VTLVHKGNIMKFTEGAFKDWGYEVAVKEFGA 265 S++ R+ R A + A R S VT V K N++ + V +E Sbjct 168 -----SRKEIERIARFAFEAA--KLRSSHVTSVDKANVLASS----------VLWREV-- 208 Query 266 KPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 V E K ++ + + D Q++ +P+++ V+ NL GD +SD A Sbjct 209 ---------VTEVSKDYPEVKLDYIYVDNAAMQLVKQPSQFDVLLCDNLFGDILSDECAM 259 Query 326 EVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 G +G+ P A+L+ + GL+E G+AP AG+ NP + ILSA +MLRY LG EAA Sbjct 260 ITGSMGLLPSASLNQSGFGLYEPAGGSAPDIAGKGVANPIAQILSAALMLRYSLGQDEAA 319 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Sodalis glossinidius str. 'morsitans'] Sequence ID: Q2NVW4.1 Length: 364 Range 1: 8 to 356 Score:79.7 bits(195), Expect:4e-15, Method:Compositional matrix adjust., Identities:101/393(26%), Positives:162/393(41%), Gaps:53/393(13%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG ++ ++DA ++ +I E G A G LP T Sbjct 8 IAVLPGDGIGPEVMAQAYKILDAVRQRF---NVRISTSEYDVGGAAIDRQGSP--LPAGT 62 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVPSPV 151 + ++ + G + P + R + LR+ L+ LRP R + G+ + Sbjct 63 VAGCEQADAILFGSVGGPKWEHLPAAEQPERGALLPLRKHFKLFSNLRPSRLYPGLEA-- 120 Query 152 KTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPV 211 P + N+ E DI E G I F Q + ++ P + Sbjct 121 YCPLRANIA---ERGFDILCVRELTGG-------IYFGQPKG--REGTGPHEHAFDTEVY 168 Query 212 SKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGG 271 + R+ R A + A R VT + K N+++ + V + D Sbjct 169 YRFEIERIARIAFESA-RKRRGKVTSIDKANVLQ------SSILWRKVVSQVAPDYPDVA 221 Query 272 PWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIG 331 H++ + T Q IKD P+++ V+ NL GD +SD A G +G Sbjct 222 LSHLYIDNATMQ--LIKD-------------PSQFDVMLCSNLFGDILSDECAMITGSMG 266 Query 332 IAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQG 389 + P A+L++ G++E G+AP AG+D NP + ILSA ++LRY LG +AAD + Sbjct 267 MLPSASLNEQGFGMYEPAGGSAPDIAGKDIANPVAQILSASLLLRYSLGLDDAADAIELA 326 Query 390 IEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 + A+E+ T D A G V T + G I Sbjct 327 VNQALEAGHRTADLA---GGGSAVGTGEMGDII 356 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudomonas syringae pv. tomato str. DC3000] Sequence ID: Q884C0.1 Length: 360 Range 1: 5 to 354 Score:79.3 bits(194), Expect:5e-15, Method:Compositional matrix adjust., Identities:104/398(26%), Positives:166/398(41%), Gaps:61/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++ A +K G E G A +G L DET Sbjct 5 ILILPGDGIGPEIMTEAVKVLELANQKYQLG---FELTHDVIGGAAIDKHGVP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 L+ + A+ GP + IR + +R QL L+ LRP + Y + Sbjct 60 LDRARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASS 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G +P ++++ E Sbjct 120 LKPEIVAGLDILIVRELTGGIYFG------APRGTRVLDN------------GERQAYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ + A+ + + V K N++ ++ +++ +VA Sbjct 162 LPYSESEIRRIAKVGFDMAMVRGKKLCS-VDKANVLASSQ-LWREIVEQVA--------- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 K ++ + + D Q++ P ++ VI T NL GD +SD + G Sbjct 211 -----------KDYPEVELSHLYVDNAAMQLVRAPKQFDVIVTDNLFGDILSDQASMLTG 259 Query 329 GIGIAPGANLSDTV--GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 IG+ P A+L DT G++E HG+AP AGQ NP + ILS MMLRY AAD Sbjct 260 SIGMLPSASL-DTANKGMYEPCHGSAPDIAGQGIANPLATILSVSMMLRYSFNLTAAADA 318 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + Q + ++ T D G +V T + G A++ Sbjct 319 IEQAVSLVLDQGIRTGDI--WSEGKVKVGTKEMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xylella fastidiosa Temecula1] Sequence ID: Q87BQ1.1 Length: 357 Range 1: 5 to 354 Score:79.0 bits(193), Expect:7e-15, Method:Compositional matrix adjust., Identities:99/400(25%), Positives:165/400(41%), Gaps:65/400(16%) Query 39 IPFIEGDGIGIDI-APVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDE 97 I + GDGIG +I A +K + V + + + + G A + YG L DE Sbjct 5 ILILPGDGIGHEIVAEAVKVLEHVNVRHTLNMRLSFDAL----GGAAYEKYGSP--LADE 58 Query 98 TLEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP-SP 150 TL +E A+ GP + +R + +R QL L+ LRP + + + Sbjct 59 TLARAREADAVLLGAVGGPQWDTIDPALRPERGLLKIRAQLGLFANLRPALLYPQLADAS 118 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V +++I RE + +Y G P GS + + E Sbjct 119 TLKPEVVAGLDILIVRELTGGLYFG--QPRGS----------------RISKNGEREAFD 160 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 P + R+++ + A + + V K N++ ++ Sbjct 161 TLPYCESEIRRILKVGFEMARLRGKKLCS-VDKANVLASSQ------------------- 200 Query 268 LDGGPWHVF--ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 W E K +T+ + D Q++ P ++ VI T N+ GD +SD + Sbjct 201 ----LWRTVAGEMAKDYPDVTLSHMYVDNAAMQLVRYPKQFDVIVTENMFGDILSDQASM 256 Query 326 EVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 G IG+ P A+L ++ G++E HG+AP AGQ NP + ILS M+LRY +G+ + A Sbjct 257 LTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGVANPLATILSVAMLLRYGMGYIKTA 316 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 D + + ++S T D G +V T G A++ Sbjct 317 DAIEYAVGVVLDSGLRTADI--WSEGMTKVGTVAMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xanthomonas oryzae pv. oryzae MAFF 311018] Sequence ID: Q2P762.1 Length: 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xanthomonas oryzae pv. oryzae KACC 10331] Sequence ID: Q5H4C7.1 Length: 357 Range 1: 5 to 357 Score:79.0 bits(193), Expect:8e-15, Method:Compositional matrix adjust., Identities:98/402(24%), Positives:163/402(40%), Gaps:63/402(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ ++ + ++ + E+ G A YG L DET Sbjct 5 ILILPGDGIGPEIMAEAVKVLQR-IDTQHGLGFELVYDEL--GGAAYDKYGSP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP-SPV 151 LE + A+ GP + +R + +R QL L+ LRP + + + Sbjct 60 LERARAADAVLLGAVGGPQWDTIDPSLRPERGLLKIRSQLGLFANLRPALLYPQLADAST 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G G + + E Sbjct 120 LKPEVVAGLDLLILRELTGGIYFG------------------QPRGNRTLDNGERQAYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ + + A + + V K N++ ++ Sbjct 162 LPYSESEICRIAKAGFEMARLRGK-KLCSVDKANVLASSQ-------------------- 200 Query 269 DGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 W V E K I + + D Q++ P ++ VI T N+ GD +SD + Sbjct 201 ---LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDQASML 257 Query 327 VGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G IG+ P A+L +++ G++E HG+AP AG+ NP + ILS MMLRY +AAD Sbjct 258 TGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGIANPLATILSVAMMLRYTFAQADAAD 317 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 + + + ++ T D G +V T G A++ + Sbjct 318 AIERAVGKVLDQGLRTADI--WSEGTTKVGTVAMGDAVVAAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xanthomonas euvesicatoria pv. vesicatoria str. 85-10] Sequence ID: Q3BPJ8.1 Length: 357 Range 1: 5 to 357 Score:79.0 bits(193), Expect:8e-15, Method:Compositional matrix adjust., Identities:101/404(25%), Positives:163/404(40%), Gaps:67/404(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIY--AGEKATKVYGKDNWLPD 96 I + GDGIG +I M V V K + + + +Y G A YG + L D Sbjct 5 ILILPGDGIGPEI---MAEAVK--VLKRIDAQHGLGFELVYDELGGAAYDKYG--SPLAD 57 Query 97 ETLEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP-S 149 ETLE + A+ GP + +R + +R QL L+ LRP + + + Sbjct 58 ETLERARAADAVLLGAVGGPQWDTIDPSLRPERGLLKIRSQLGLFANLRPALLYPQLADA 117 Query 150 PVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 PE V +++I RE + IY G G + + E Sbjct 118 STLKPEVVAGLDLLILRELTGGIYFG------------------QPRGNRTLDNGERQAY 159 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 P S+ R+ + + A + + V K N++ ++ Sbjct 160 DTLPYSESEIRRIAKAGFEMARLRGKKLCS-VDKANVLASSQ------------------ 200 Query 267 PLDGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 W V E K I + + D Q++ P ++ VI T N+ GD +SD + Sbjct 201 -----LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDQAS 255 Query 325 AEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L +++ G++E HG+AP AG+ NP + ILS MMLRY +A Sbjct 256 MLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGIANPLATILSVAMMLRYTFAQADA 315 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 AD + + + ++ T D G +V T G A++ + Sbjct 316 ADAIERAVGKVLDQGLRTADI--WSEGTTKVGTVAMGDAVVAAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudomonas syringae pv. syringae B728a] Sequence ID: Q4ZUZ4.1 Length: 360 Range 1: 5 to 354 Score:78.6 bits(192), Expect:8e-15, Method:Compositional matrix adjust., Identities:103/398(26%), Positives:167/398(41%), Gaps:61/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++ A EK G E G A +G L DET Sbjct 5 ILILPGDGIGPEIMTEAVKVLELANEKYQLG---FELTHDVIGGAAIDKHGVP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 LE + A+ GP + IR + +R QL L+ LRP + Y + Sbjct 60 LERARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASS 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G +P ++++ E Sbjct 120 LKPEIVAGLDIMIVRELTGGIYFG------APRGTRVLDN------------GERQAYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ + A+ + + V K N++ ++ +++ +VA Sbjct 162 LPYSESEIRRIAKVGFDMAMVRGK-KLCSVDKANVLASSQ-LWREIVEQVA--------- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 + ++ + + D Q++ P ++ VI T NL GD +SD + G Sbjct 211 -----------RDYPEVELSHMYVDNAAMQLVRAPKQFDVIVTDNLFGDILSDQASMLTG 259 Query 329 GIGIAPGANLSDTV--GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 IG+ P A+L DT G++E HG+AP AG+ NP + ILS MMLRY +AAD Sbjct 260 SIGMLPSASL-DTANKGMYEPCHGSAPDIAGKGIANPLATILSVSMMLRYSFNLTDAADA 318 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + + + ++ T D G +V T + G A++ Sbjct 319 IEKAVSLVLDQGIRTGDI--WSEGKVKVGTQEMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola str. Bp (Baizongia pistaciae)] Sequence ID: P59515.1 Length: 366 Range 1: 57 to 359 Score:78.6 bits(192), Expect:1e-14, Method:Compositional matrix adjust., Identities:89/350(25%), Positives:146/350(41%), Gaps:63/350(18%) Query 94 LPDETLEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTG 146 LP +TL+ ++ + G + P + R + LR+ +L+ LR R ++G Sbjct 57 LPKKTLQGCRDSHAILFGSIGGPKWEDLPSHLQPERGALLPLRKYFNLFSNLRLARIYSG 116 Query 147 VP--SPVKTPEK---VNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFP 201 + SP+K+ +++ RE + IY G P GS + L E+ Sbjct 117 LEKLSPLKSRISNLGCDILCVRELTGGIYFGD--PKGSKVSKSLNCAFDTEV-------- 166 Query 202 ETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVK 261 + R+ A A+ R VT + K N+++ F Sbjct 167 ---------YYQFEIERIAHMAFDLALTR-RCKVTSIDKANVLE--SSMF---------- 204 Query 262 EFGAKPLDGGPWHVFENPKTGQ--KITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYI 319 W N + Q ++ + + D QI+ P+++ V+ NL GD + Sbjct 205 -----------WRKIVNRISTQYSQVKLSHLYVDNAAMQIIKNPSQFDVLLCSNLFGDIL 253 Query 320 SDALAAEVGGIGIAPGANLSD-TVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-L 377 SD AA G IG+ P A+L+D GL+E G+AP G++ NP +LILS MM+RY Sbjct 254 SDECAAITGSIGLLPSASLNDKNFGLYEPAGGSAPDIKGKNIANPIALILSIGMMMRYSF 313 Query 378 GWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 + ADL+ + ++ T D + K ++TS G II IL Sbjct 314 KLYDVADLIDWAVNKTLKLGYRTQDISE---NNKFINTSSMGD-IIAEIL 359 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudomonas savastanoi pv. phaseolicola 1448A] Sequence ID: Q48K97.1 Length: 360 Range 1: 5 to 354 Score:78.2 bits(191), Expect:1e-14, Method:Compositional matrix adjust., Identities:103/398(26%), Positives:167/398(41%), Gaps:61/398(15%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++ A EK G E G A +G L DET Sbjct 5 ILILPGDGIGPEIMTEAVKVLELANEKYQLG---FELTHDVIGGAAIDKHGVP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 L+ + A+ GP + IR + +R QL L+ LRP + Y + Sbjct 60 LDRARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASS 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G +P ++++ E Sbjct 120 LKPEIVAGLDILIVRELTGGIYFG------APRGTRVLDN------------GERQAYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ + A+ + + V K N++ ++ +++ +VA Sbjct 162 LPYSESEIRRIAKVGFDMAMVRGK-KLCSVDKANVLASSQ-LWREIVEQVA--------- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 K ++ + + D Q++ P ++ VI T NL GD +SD + G Sbjct 211 -----------KDYPEVELSHMYVDNAAMQLVRAPKQFDVIVTDNLFGDILSDQASMLTG 259 Query 329 GIGIAPGANLSDTV--GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADL 385 IG+ P A+L DT G++E HG+AP AG+ NP + ILS MMLRY +AAD Sbjct 260 SIGMLPSASL-DTANKGMYEPCHGSAPDIAGKGIANPLATILSVSMMLRYSFNLTDAADA 318 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + + + ++ T D G +V T + G A++ Sbjct 319 IEKAVSVVLDQGIRTGDI--WSEGKVKVGTQEMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Pseudomonas putida KT2440] Sequence ID: Q88LE5.1 Length: 360 Range 1: 5 to 354 Score:78.2 bits(191), Expect:1e-14, Method:Compositional matrix adjust., Identities:100/397(25%), Positives:164/397(41%), Gaps:59/397(14%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V++ A +K G G A +G L DET Sbjct 5 ILILPGDGIGPEIMAEAVKVLELANDKFQLG---FSLAHDVIGGAAIDKHGVP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRP-VRYFTGVPSPV 151 LE ++ A+ GP + IR + +R QL L+ LRP + Y + Sbjct 60 LERARKADAVLLGAVGGPKWDKIERDIRPERGLLKIRSQLGLFANLRPAILYPQLADASS 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G +P G +++ E Sbjct 120 LKPEIVSGLDILIVRELTGGIYFG------APR------------GQRELEGGERQAYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ R A + + V K N++ ++ +++ +VA Sbjct 162 LPYSESEVRRIARVGFDMARVRGK-KLCSVDKANVLASSQ-LWREVVEDVA--------- 210 Query 269 DGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVG 328 K + + + D Q++ P ++ V+ T N+ GD +SD + G Sbjct 211 -----------KDYPDVELSHMYVDNAAMQLVRAPKQFDVMVTDNMFGDILSDEASMLTG 259 Query 329 GIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 IG+ P A+L +D G++E HG+AP AG NP + ILS MMLRY AA+ + Sbjct 260 SIGMLPSASLDADNKGMYEPCHGSAPDIAGLGIANPLATILSVSMMLRYSFNQSAAAEAI 319 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 + + ++ T D G ++V T + G A++ Sbjct 320 EKAVSLVLDQGLRTGDI--FSEGCRKVGTQEMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Arthrospira platensis] Sequence ID: Q00412.1 Length: 355 Range 1: 217 to 352 Score:78.2 bits(191), Expect:1e-14, Method:Compositional matrix adjust., Identities:51/138(37%), Positives:75/138(54%), Gaps:4/138(2%) Query 284 KITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-V 342 ++ + + D Q++ P ++ I T NL GD +SDA A G IG+ P A+L + Sbjct 217 EVELSHLYVDNAAMQLVRWPKQFDTIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGP 276 Query 343 GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTY 401 G+FE HG+AP AGQDK NP + +LSA MMLRY L A+D V + + ++ T Sbjct 277 GVFEPVHGSAPDIAGQDKANPLAQVLSAAMMLRYGLDEPAASDPVEKAVLKVLDWGYPTG 336 Query 402 DFARLMTGAKEVSTSQFG 419 D + G K V ++G Sbjct 337 DI--MSEGMKAVGCRKWG 352 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xylella fastidiosa 9a5c] Sequence ID: Q9PAX3.1 Length: 357 Range 1: 5 to 354 Score:77.4 bits(189), Expect:2e-14, Method:Compositional matrix adjust., Identities:98/400(25%), Positives:164/400(41%), Gaps:65/400(16%) Query 39 IPFIEGDGIGIDI-APVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDE 97 I + GDGIG +I A +K + V + + + + G A + YG L DE Sbjct 5 ILILPGDGIGHEIVAEAVKVLEHVNVRHTLNLRLSFDAL----GGAAYEKYGSP--LADE 58 Query 98 TLEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP-SP 150 TL ++ A+ GP + +R + +R QL L+ LRP + + + Sbjct 59 TLARARDADAVLLGAVGGPQWDTIDPALRPERGLLKIRAQLGLFANLRPALLYPQLADAS 118 Query 151 VKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIG 207 PE V +++I RE + +Y G P GS + + E Sbjct 119 TLKPEVVAGLDILIVRELTGGLYFG--QPRGS----------------RISKNGEREAFD 160 Query 208 IKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 P + R+++ + A + + V K N++ ++ Sbjct 161 TLPYCESEIRRILKVGFEMARLRGKKLCS-VDKANVLASSQ------------------- 200 Query 268 LDGGPWHVF--ENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAA 325 W E K +T+ + D Q++ P ++ VI T N+ GD +SD + Sbjct 201 ----LWRTVAGEMAKDYPDVTLSHMYVDNAAMQLVRHPKQFDVIVTENMFGDILSDQASM 256 Query 326 EVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 G IG+ P A+L ++ G++E HG+AP AGQ NP + ILS M+LRY +G + A Sbjct 257 LTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGVANPLATILSVAMLLRYSMGHIKTA 316 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAII 423 D + + ++S T D G +V T G A++ Sbjct 317 DAIEHAVGVVLDSGLRTADI--WSEGMTKVGTVAMGDAVV 354 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Pemphigus spyrothecae)] Sequence ID: P59027.1 Length: 363 Range 1: 7 to 359 Score:77.0 bits(188), Expect:3e-14, Method:Compositional matrix adjust., Identities:105/405(26%), Positives:173/405(42%), Gaps:68/405(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG ++ + K++ +++ Y K KI E G A YGK LP ET Sbjct 7 LAILPGDGIGPEL--LQKDLNFKVLKEQY--KLKINTTEYDIGGIAIDKYGK--ALPKET 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGVP--S 149 L+ KE + G + P + R+ + +R+ +L+ LRP + ++ + S Sbjct 61 LDGCKESDSILFGSVGGPKWQHLPPDQQPERAALLPIRKYFNLFSNLRPAKLYSTLNHLS 120 Query 150 PVK---TPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P++ + + +++ RE + IY G P G +++N + K Sbjct 121 PLRRDISEKGFDILCVRELTGGIYFG--KPKG---------YIKNIIDKKAFDTEIYYAS 169 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 IK ++ G R + +T V K N++ E +V Sbjct 170 EIKRIAHIGFKLAQNRKYK---------ITSVDKANVL------------ESSVL----- 203 Query 267 PLDGGPWHVFEN--PKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 W N K + + + D QI+ P ++ VI T NL GD +SD A Sbjct 204 ------WRETVNTISKEYPDVKLSHLYIDHAAMQIIKNPDKFDVILTSNLFGDILSDECA 257 Query 325 AEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L+D+ GL+E G+AP AG++ NP + ILS M++RY + Sbjct 258 MITGSIGMLPSASLNDSNFGLYEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPMI 317 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHIL 427 +D + + ++ T D A K VST+ G II IL Sbjct 318 SDHIESAVIDTLKKGYRTLDIAN--DKEKYVSTNDIGD-IISDIL 359 >RecName: Full=3-isopropylmalate dehydrogenase gloI; AltName: Full=L-homotyrosine biosynthesis sub-cluster protein gloI; AltName: Full=Pneumocandin biosynthesis cluster protein I [Glarea lozoyensis ATCC 20868] Sequence ID: S3DB74.1 Length: 373 Range 1: 220 to 363 Score:77.0 bits(188), Expect:3e-14, Method:Compositional matrix adjust., Identities:52/150(35%), Positives:73/150(48%), Gaps:17/150(11%) Query 285 ITIKDVIADAFLQQILLRPAEYS-VIATLNLNGDYISDALAAEVGGIGIAPGANL----- 338 I + ++ D + RP + +I T N+ GD ISD +A G +G+ P A+L Sbjct 220 IKLSHMLIDTAAMNVARRPTSLNGIILTSNMFGDIISDEASAIPGSLGLLPSASLCAIPT 279 Query 339 ----SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGA 393 S G++E HG+AP AGQ +NP +ILS MMLRY L EAAD + + Sbjct 280 VLDASKVRGIYEPIHGSAPDIAGQGIINPTGMILSVAMMLRYSLAMPEAADSIEAAVGKV 339 Query 394 IESKTVTYDFARLMTGAKEVSTSQFGKAII 423 IE T D ST+ FG A++ Sbjct 340 IEDDCRTSDI------GGRASTADFGDAVV 363 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xanthomonas citri pv. citri str. 306] Sequence ID: Q8PH05.1 Length: 357 Range 1: 5 to 357 Score:76.6 bits(187), Expect:4e-14, Method:Compositional matrix adjust., Identities:101/404(25%), Positives:159/404(39%), Gaps:67/404(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIY--AGEKATKVYGKDNWLPD 96 I + GDGIG +I M V V K + + + +Y G A YG L D Sbjct 5 ILILPGDGIGPEI---MAEAVK--VLKRIDAQHGLGFQLVYDELGGTAYDKYGSP--LAD 57 Query 97 ETLEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP-S 149 ETLE + A+ GP + +R + +R QL L+ LRP + + + Sbjct 58 ETLERARGADAVLLGAVGGPQWDTIDPALRPERGLLKIRSQLGLFANLRPALLYPQLADA 117 Query 150 PVKTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 PE V +++I RE + IY G G + + E Sbjct 118 STLKPEVVAGLDLLILRELTGGIYFG------------------QPRGNRTLDNGERQAY 159 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 P S+ R+ + A + + V K N++ ++ Sbjct 160 DTLPYSESEIRRIAKAGFDMARLRGKKLCS-VDKANVLASSQ------------------ 200 Query 267 PLDGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 W V E K I + + D Q++ P ++ VI T N+ GD +SD + Sbjct 201 -----LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDQAS 255 Query 325 AEVGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEA 382 G IG+ P A+L +++ G++E HG+AP AG+ NP + ILS MMLRY A Sbjct 256 MLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGIANPLATILSVAMMLRYTFARATA 315 Query 383 ADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 AD + + ++ T D G +V T G A++ + Sbjct 316 ADAIEHAVGKVLDQGLRTADI--WSEGTTKVGTVAMGDAVVAAL 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Dehalococcoides mccartyi 195] Sequence ID: Q3Z896.1 Length: 365 Range 1: 206 to 363 Score:76.6 bits(187), Expect:5e-14, Method:Compositional matrix adjust., Identities:51/160(32%), Positives:82/160(51%), Gaps:10/160(6%) Query 275 VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAP 334 V E K IT++ ++ DA +++L P + VI T N+ GD ++D + G +G+ P Sbjct 206 VIEIAKDYPDITVEHILVDACAMKLILAPTYFDVIVTENMFGDILTDEASMLAGSMGMLP 265 Query 335 GANL-------SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLV 386 A+L + T GL+E HG+AP A Q+ NP + ILS MMLRY G + A + Sbjct 266 SASLAGIPAKGTKTFGLYEPIHGSAPTIAKQNIANPIATILSIAMMLRYSCGLETEAAEI 325 Query 387 VQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 ++ + + T D + G ++ T++ G I K I Sbjct 326 EAAVDKVLAAGYATIDIFK--EGNTKLGTAEMGSQIAKII 363 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xanthomonas campestris pv. campestris str. 8004] Sequence ID: Q4UYG2.1 Length: 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Xanthomonas campestris pv. campestris str. ATCC 33913] Sequence ID: Q8P5L1.1 Length: 357 Range 1: 5 to 308 Score:75.1 bits(183), Expect:1e-13, Method:Compositional matrix adjust., Identities:89/351(25%), Positives:142/351(40%), Gaps:60/351(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I V+ ++ + + + E+ G A YG L DET Sbjct 5 ILILPGDGIGPEIMAEAVKVL-TRIDTQHTLGVTLVYDEL--GGAAYDKYGSP--LADET 59 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLN--VALRQQLDLYVCLRPVRYFTGVP-SPV 151 LE + A+ GP + +R + +R QL L+ LRP + + + Sbjct 60 LERARAADAVLLGAVGGPQWDTIDPALRPERGLLKIRSQLGLFANLRPALLYPQLADAST 119 Query 152 KTPEKV---NMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGI 208 PE V +++I RE + IY G G + + E Sbjct 120 LKPEVVSGLDLLILRELTGGIYFG------------------QPRGTRTLDNGERQAYDT 161 Query 209 KPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPL 268 P S+ R+ + + A + + V K N++ ++ Sbjct 162 LPYSESEIRRIAKAGFEMARLRGKKLCS-VDKANVLASSQ-------------------- 200 Query 269 DGGPWH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 W V E K I + + D Q++ P ++ VI T N+ GD +SD + Sbjct 201 ---LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDQASML 257 Query 327 VGGIGIAPGANL-SDTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY 376 G IG+ P A+L +++ G++E HG+AP AGQ NP + ILS MMLRY Sbjct 258 TGSIGMLPSASLDANSKGMYEPCHGSAPDIAGQGIANPLATILSVAMMLRY 308 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Synechococcus elongatus PCC 7942 = FACHB-805] Sequence ID: Q31N34.1 Length: 365 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Synechococcus elongatus PCC 6301] Sequence ID: Q5MZ40.2 Length: 365 Range 1: 218 to 338 Score:75.1 bits(183), Expect:1e-13, Method:Compositional matrix adjust., Identities:46/121(38%), Positives:66/121(54%), Gaps:2/121(1%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANL-SDTVG 343 + + + D Q++ P ++ I T NL GD +SD A G IG+ P A+L ++ G Sbjct 218 VELSHLYVDNAAMQLVRWPKQFDTIVTGNLFGDILSDIAAMLTGSIGMLPSASLGAEGPG 277 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 +FE HG+AP AGQDK NP + +LSA MMLRY L EAA + + ++ T D Sbjct 278 VFEPVHGSAPDIAGQDKANPLAQVLSAAMMLRYGLDEPEAAARIEAAVNQVLDQGYRTGD 337 Query 403 F 403 Sbjct 338 L 338 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Thelaxes suberi)] Sequence ID: O31292.1 Length: 364 Range 1: 8 to 341 Score:73.2 bits(178), Expect:6e-13, Method:Compositional matrix adjust., Identities:90/385(23%), Positives:166/385(43%), Gaps:69/385(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GDGIG +I ++D ++K ++ K+ +I G + +G L ET Sbjct 8 IAVLPGDGIGPEIIQEAYKIIDV-LQKKFSFNVKMHEYDI--GGISIDKHG--TALTQET 62 Query 99 LEAIKEYQVAIKGP-----------LTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGV 147 +E + + G + P G+ + LR+ +L+ +RP + + Sbjct 63 IEGCENSDAILFGSVGGSKWDHLPEIEKPEKAGL----LKLRKHFNLFANIRPCKLSQHL 118 Query 148 P--SPVKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPE 202 SP+K + ++++ RE + IY G ++ K+ N +I F Sbjct 119 LDISPLKNSIIKKGIDLICIRELTGGIYFG--------KSNKITNIDDPYAFDTEIYF-- 168 Query 203 TAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKE 262 + R+ + A Q A + + + + K N++K + ++D ++A K Sbjct 169 ----------RSEIKRIAKIAFQIA-QSRKKKIVSIDKANVLK-SSILWRDTVNKMAYK- 215 Query 263 FGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDA 322 F N K ++ + D +++ P+ + VI NL GD ISD Sbjct 216 -------------FPNVK------LEHMYIDNATMELIKNPSSFDVILCSNLFGDIISDE 256 Query 323 LAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWK 380 AA +G IG+ P A+L+ + GL+E G+AP AG+ NP + ILS M+L+Y L Sbjct 257 CAAIIGSIGLLPSASLNKSGFGLYEPAGGSAPNIAGKTIANPIAQILSLSMLLKYSLHLP 316 Query 381 EAADLVVQGIEGAIESKTVTYDFAR 405 + + + + A+ K +T D ++ Sbjct 317 FLSSCIDEAVHEALVKKYMTMDISK 341 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Schizosaccharomyces pombe 972h-] Sequence ID: P18869.1 Length: 371 Range 1: 6 to 367 Score:71.6 bits(174), Expect:2e-12, Method:Compositional matrix adjust., Identities:109/414(26%), Positives:171/414(41%), Gaps:78/414(18%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 I + GD IG +I V+ VEK + K+E+ E G + YG L DET Sbjct 6 IVVLPGDHIGPEIVASALEVLKV-VEKKRP-ELKLEFEEHKIGGASIDAYGTP--LTDET 61 Query 99 LEAIKEYQV----AIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVP---SPV 151 ++A E A+ GP T + LR+ + ++ LRP + + SP+ Sbjct 62 VKACLEADGVLLGAVGGPEWTNPNCRPEQGLLKLRKSMGVWANLRPCNFASKSLVKYSPL 121 Query 152 KTP--EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIK 209 K E V+ + RE + Y G E G G Sbjct 122 KPEIVEGVDFCVVRELTGGCYFG--------------------------ERTEDNGSGYA 155 Query 210 ----PVSKEGTSRLVRRAIQYA-IDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFG 264 P S E SR+ R A A N VTL+ K N++ + + W VA Sbjct 156 MDTWPYSLEEVSRIARLAAWLAETSNPPAPVTLLDKANVLATS----RLWRKTVA----- 206 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYS-VIATLNLNGDYISDAL 323 +F+ + +T+K+ + D+ ++ P + V+ T NL GD ISD Sbjct 207 ---------KIFK--EEYPHLTLKNQLIDSAAMLLVKSPRTLNGVVLTDNLFGDIISDEA 255 Query 324 AAEVGGIGIAPGANLSDTVG--------LFEATHGTAPKYAGQDKVNPGSLILSAEMMLR 375 + G +G+ P A+LS VG L E HG+AP AG+ VNP ILSA ++LR Sbjct 256 SVIPGSLGLLPSASLSGVVGKSEEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLR 315 Query 376 Y-LGWKEAADLVVQGIEGAIESKTVTYD--FARLMTGAKEVSTSQFGKAIIKHI 426 Y L + A+ + + ++ ++ + R + G E ST+ KA+++ + Sbjct 316 YGLNAPKEAEAIEAAVRKVLDDTSIGGRGLYTRDLGG--EASTADITKAVVEEL 367 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola BCc] Sequence ID: Q5WPZ9.1 Length: 367 Range 1: 235 to 362 Score:71.2 bits(173), Expect:3e-12, Method:Compositional matrix adjust., Identities:43/131(33%), Positives:71/131(54%), Gaps:5/131(3%) Query 298 QILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDTV-GLFEATHGTAPKYA 356 Q++ P ++ VI NL GD +SD AA G +G+ P A+L+++ GLFE G+AP Sbjct 235 QLIKNPNQFDVILCSNLFGDILSDECAALTGSLGMLPSASLNESFFGLFEPAGGSAPDLK 294 Query 357 GQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVST 415 G++ NP + ILS ++ +Y L ++ + L+ + +E T D + G K ++T Sbjct 295 GKNIANPIAQILSLALLFKYSLQLEKISHLIELSVLKTLEKGYRTLDIS---NGKKYITT 351 Query 416 SQFGKAIIKHI 426 Q G I K + Sbjct 352 DQMGNYIAKTL 362 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola str. Sg (Schizaphis graminum)] Sequence ID: O85064.1 Length: 363 Range 1: 219 to 355 Score:69.3 bits(168), Expect:1e-11, Method:Compositional matrix adjust., Identities:42/140(30%), Positives:71/140(50%), Gaps:5/140(3%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-VG 343 + + + D QI+ P ++ ++ N+ GD ISD A G IG+ P A+L++ G Sbjct 219 VHLSHLYIDNACMQIIKNPTQFDILLCSNIFGDIISDECAMITGSIGMLPSASLNNQKFG 278 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 L+E G+AP G++ NP + ILS M++RY + E AD + + A++ T D Sbjct 279 LYEPAGGSAPDIEGKNIANPIAQILSLSMLIRYSMNLNEIADKIDLSVHYALKEGYRTLD 338 Query 403 FARLMTGAKEVSTSQFGKAI 422 + G + T++ G I Sbjct 339 IS---DGKNYIKTNEMGDII 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon obscurum)] Sequence ID: Q9EVI1.1 Length: 364 Range 1: 220 to 356 Score:68.9 bits(167), Expect:1e-11, Method:Compositional matrix adjust., Identities:43/140(31%), Positives:73/140(52%), Gaps:5/140(3%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-VG 343 + + + D + QI+ P ++ V+ NL GD ISD A G IG+ P A+L++ G Sbjct 220 VDLSHLYIDNAIMQIIKNPNQFDVLLCPNLFGDIISDECAIITGSIGMLPSASLNEKKFG 279 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 L+E G+AP AG++ NP + ILS M++RY + K+ AD + + + ++ T D Sbjct 280 LYEPAGGSAPDIAGKNIANPIAQILSLSMLVRYGMNLKDIADKIDKSVLSVLKKGYRTAD 339 Query 403 FARLMTGAKEVSTSQFGKAI 422 + + T++ G I Sbjct 340 IS---NNNNYLKTNEMGDVI 356 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Macrosiphoniella ludovicianae)] Sequence ID: Q9EVG3.1 Length: 365 Range 1: 220 to 341 Score:68.6 bits(166), Expect:2e-11, Method:Compositional matrix adjust., Identities:38/122(31%), Positives:67/122(54%), Gaps:2/122(1%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD-TVG 343 + + + D QI+ P ++ ++ NL GD +SD A G IG+ P A+L++ G Sbjct 220 VHLSHLYIDNATMQIIQNPNQFDILLCSNLFGDILSDECAIITGSIGMLPSASLNEKNFG 279 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 L+E G+AP AG++ NP + ILS M++RY + K+ A+ + Q + ++ T+D Sbjct 280 LYEPAGGSAPDIAGKNIANPIAQILSLSMLVRYGMNLKKIANKIDQSVISVLKKGYRTFD 339 Query 403 FA 404 + Sbjct 340 IS 341 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Sordaria macrospora] Sequence ID: Q6TWC4.1 Length: 368 Range 1: 206 to 362 Score:68.2 bits(165), Expect:2e-11, Method:Compositional matrix adjust., Identities:54/163(33%), Positives:76/163(46%), Gaps:28/163(17%) Query 286 TIKDVIADAF----LQQILLRPAEY----------SVIATLNLNGDYISDALAAEVGGIG 331 T+ DVI+ F L+ L+ A V+ T NL GD ISD + G IG Sbjct 206 TVTDVISKEFPQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEASVIPGSIG 265 Query 332 IAPGANLS-------DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 + P A+L G++E HG+AP +G+ VNP ILS MMLRY L + A Sbjct 266 LLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRYSLNLPKEA 325 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 D V ++ AI++ T T D +TS G A++ + Sbjct 326 DAVEAAVKAAIDNGTKTKDL------GGSATTSDMGNAVVAEL 362 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Neurospora crassa OR74A] Sequence ID: P34738.2 Length: 368 Range 1: 206 to 362 Score:68.2 bits(165), Expect:3e-11, Method:Compositional matrix adjust., Identities:54/163(33%), Positives:76/163(46%), Gaps:28/163(17%) Query 286 TIKDVIADAF----LQQILLRPAEY----------SVIATLNLNGDYISDALAAEVGGIG 331 T+ DVI+ F L+ L+ A V+ T NL GD ISD + G IG Sbjct 206 TVTDVISKEFPQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEASVIPGSIG 265 Query 332 IAPGANLS-------DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAA 383 + P A+L G++E HG+AP +G+ VNP ILS MMLRY L + A Sbjct 266 LLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRYSLNLPKEA 325 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 D V ++ AI++ T T D +TS G A++ + Sbjct 326 DAVEAAVKAAIDNGTKTKDL------GGNATTSDMGNAVVAEL 362 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon solidaginis)] Sequence ID: Q9EVI4.1 Length: 363 Range 1: 98 to 355 Score:68.2 bits(165), Expect:3e-11, Method:Compositional matrix adjust., Identities:74/307(24%), Positives:125/307(40%), Gaps:61/307(19%) Query 128 LRQQLDLYVCLRPVRYFTGV--PSPVKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEA 182 LR+ +L+ LRP + ++ + SP+++ N++ RE + IY G PAG Sbjct 98 LRKHFNLFGNLRPAQLYSELIHLSPLRSDIINNGFNILCIRELTGGIYFG--KPAG---- 151 Query 183 VKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGN 242 RL + I+YA D + + + Sbjct 152 -----------------------------------RLKKNNIEYAFDTE-----IYYNYE 171 Query 243 IMKFTEGAF---KDWGYEVAVKEFGAKPLDGGPWH--VFENPKTGQKITIKDVIADAFLQ 297 I + AF K Y+V + W V + K + + + D Sbjct 172 INRIAHLAFQLAKTRNYKVCSIDKSNVLNSSILWREIVQKVSKNYPDVHLSHLYIDNATM 231 Query 298 QILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-VGLFEATHGTAPKYA 356 QI+ P ++ ++ NL GD ISD A G IG+ P A+L++ GL+E G+AP Sbjct 232 QIIKNPNQFDILLCSNLFGDIISDECAMITGSIGMLPSASLNEKKFGLYEPAGGSAPDIE 291 Query 357 GQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVST 415 G++ NP + ILS M++RY + K AD + Q + ++ T D + + + T Sbjct 292 GKNIANPIAQILSVSMLVRYSMNLKTIADKIDQSVISVLKKGYRTADIS---NNSHYLKT 348 Query 416 SQFGKAI 422 ++ G I Sbjct 349 NEMGDVI 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon aeneum)] Sequence ID: Q9EVG6.1 Length: 363 Range 1: 92 to 355 Score:67.8 bits(164), Expect:4e-11, Method:Compositional matrix adjust., Identities:75/313(24%), Positives:128/313(40%), Gaps:61/313(19%) Query 122 RSLNVALRQQLDLYVCLRPVRYFTGVP--SPVKT---PEKVNMVIFRENSEDIYAGIEWP 176 R+ + LR+ +L+ LRP + ++ + SP+++ N++ RE + IY G Sbjct 92 RASLLPLRKHFNLFANLRPAQLYSELKNLSPLRSNIIKNGFNILCIRELTGGIYFG---- 147 Query 177 AGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVT 236 KP T RL + I+YA D + Sbjct 148 --------------------------------KP-----TGRLKKNNIEYAFDTE----- 165 Query 237 LVHKGNIMKFTEGAFK---DWGYEVAVKEFGAKPLDGGPWH--VFENPKTGQKITIKDVI 291 + + I + AF+ Y+V + W V + K + + + Sbjct 166 IYYNYEINRIAHLAFQLSQTRNYKVCSIDKSNVLNSSILWREIVKKVSKHYPDVHLSHLY 225 Query 292 ADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-VGLFEATHG 350 D QI+ P ++ V+ NL GD ISD A G IG+ P A+L++ GL+E G Sbjct 226 IDNATMQIIKDPNQFDVLLCSNLFGDIISDECAMITGSIGMLPSASLNEKKFGLYEPAGG 285 Query 351 TAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTG 409 +AP G++ NP + ILS M++RY + K+ AD + Q + ++ T D + Sbjct 286 SAPDIEGKNIANPIAQILSLSMLVRYSMNLKKIADKIDQSVISVLKKGYRTADIS---NN 342 Query 410 AKEVSTSQFGKAI 422 + T++ G I Sbjct 343 NDYLKTNEMGDVI 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon rudbeckiae)] Sequence ID: Q9EVE1.1 Length: 363 Range 1: 150 to 355 Score:66.2 bits(160), Expect:1e-10, Method:Compositional matrix adjust., Identities:57/218(26%), Positives:95/218(43%), Gaps:23/218(10%) Query 216 TSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKPLDGGP--- 272 T RL + I+YA D + + + I + AF+ + F +D Sbjct 150 TGRLKKNNIEYAFDTE-----IYYNYEITRIAHLAFQ----LAQTRNFKICSIDKSNVLN 200 Query 273 ----WH--VFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 W V + K + + + D QI+ P ++ ++ NL GD ISD A Sbjct 201 SSVLWREIVKKVSKNYPDVHLSHLYIDNATMQIIKDPNQFDILLCSNLFGDIISDECAII 260 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAAD 384 G IG+ P A+L++ GL+E G+AP G++ NP + ILS M++RY + K AD Sbjct 261 TGSIGMLPSASLNEKKFGLYEPAGGSAPDIEGKNIANPIAQILSVSMLVRYGMNLKTIAD 320 Query 385 LVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAI 422 + Q + ++ T D + + T++ G I Sbjct 321 KIDQSVISVLKKGYRTADIS---NNNNYLKTNEMGDVI 355 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon rurale)] Sequence ID: Q9AQC8.1 Length: 126 Range 1: 2 to 103 Score:62.0 bits(149), Expect:1e-10, Method:Composition-based stats., Identities:35/102(34%), Positives:59/102(57%), Gaps:2/102(1%) Query 305 EYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD-TVGLFEATHGTAPKYAGQDKVNP 363 ++ ++ NL GD ISD A G IG+ P A+ ++ GL+E G+AP AG++ NP Sbjct 2 QFDILLCSNLFGDIISDECAVITGSIGMLPSASFNEKNFGLYEPAGGSAPDIAGKNIANP 61 Query 364 GSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFA 404 + ILS M++RY + K+ AD + + + A+++ T D + Sbjct 62 IAQILSLSMLVRYGMKLKKIADKIDKSVASALKAGYRTADIS 103 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon ambrosiae)] Sequence ID: Q9EVG9.1 Length: 365 Range 1: 221 to 357 Score:66.2 bits(160), Expect:1e-10, Method:Compositional matrix adjust., Identities:41/140(29%), Positives:71/140(50%), Gaps:5/140(3%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-VG 343 + + + D QI+ P ++ ++ NL GD +SD A G IG+ P A+L++ G Sbjct 221 VHLSHLYIDNATMQIIKDPNQFDILLCSNLFGDIVSDECAIITGSIGMLPSASLNEKKFG 280 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 L+E G+AP G++ NP + ILS M++RY + K+ AD + Q + ++ T D Sbjct 281 LYEPAGGSAPDIEGKNIANPIAQILSVSMLVRYGMNLKKIADKIDQSVISVLKKGYRTAD 340 Query 403 FARLMTGAKEVSTSQFGKAI 422 + + T++ G I Sbjct 341 IS---NNNNYLKTNEMGDVI 357 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon helianthicola)] Sequence ID: Q9EVH8.1 Length: 363 Range 1: 219 to 340 Score:65.1 bits(157), Expect:2e-10, Method:Compositional matrix adjust., Identities:38/122(31%), Positives:65/122(53%), Gaps:2/122(1%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD-TVG 343 + + + D QI+ P ++ V+ NL GD ISD A G IG+ P A+ ++ G Sbjct 219 VHLSHLYIDNATMQIIKNPNQFDVLLCSNLFGDIISDECAVITGSIGMLPSASFNEKNFG 278 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 L+E G+AP AG++ NP + ILS M++RY + + AD + + ++++ T D Sbjct 279 LYEPAGGSAPDIAGKNTANPIAQILSLSMLVRYGMKLNKIADKIDDAVALSLKAGYRTAD 338 Query 403 FA 404 + Sbjct 339 IS 340 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Diuraphis noxia)] Sequence ID: O85071.1 Length: 363 Range 1: 219 to 355 Score:65.1 bits(157), Expect:3e-10, Method:Compositional matrix adjust., Identities:40/140(29%), Positives:70/140(50%), Gaps:5/140(3%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD-TVG 343 + + + D QI+ P ++ V+ NL GD ISD A G IG+ P A+L++ G Sbjct 219 VILSHLYIDNVCMQIIKDPNQFDVLLCSNLFGDIISDECAMITGSIGMLPSASLNEKNFG 278 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 L+E G+AP G++ NP + ILS M++RY + + A+ + + ++ T D Sbjct 279 LYEPAGGSAPDIQGKNIANPIAQILSLSMLIRYSMNLNKIANKIDNAVINVLKKGYKTMD 338 Query 403 FARLMTGAKEVSTSQFGKAI 422 ++ + T++ G I Sbjct 339 ISK---DQNYLKTNEMGDVI 355 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Hapsidospora chrysogena] Sequence ID: Q12545.1 Length: 380 Range 1: 63 to 369 Score:65.1 bits(157), Expect:3e-10, Method:Compositional matrix adjust., Identities:85/356(24%), Positives:142/356(39%), Gaps:79/356(22%) Query 99 LEAIKEYQVAIKGPLTTPVGGGIR----SLNVALRQQLDLYVCLRPVRYFTGVPSPV-KT 153 L+A K + G + P G+ S + LRQ LD + LRP + VPS V + Sbjct 63 LDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFL--VPSLVGAS 120 Query 154 PEKVNMV------IFRENSEDIYAGIE----------WPAGSPEAVKLINFLQNEMGVKK 197 P + ++V + REN Y G + W PE +L Sbjct 121 PIREHVVKGTRFIVVRENCGGAYFGEKKEEEDVASDLWVYTRPEIERLARV--------- 171 Query 198 IRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYE 257 +R++ R+ DN +V K N++ + ++ + Sbjct 172 ---------------SAAVARIMGRSED---DNQAATVWSADKANVLA-SGRLWRRITSD 212 Query 258 VAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYS-VIATLNLNG 316 + KEF IT++ +AD+ ++ P ++ VI T N G Sbjct 213 IFAKEF-------------------PDITLQHQLADSMAMLMVRDPRRFNGVIHTDNTFG 253 Query 317 DYISDALAAEVGGIGIAPGANLSD-------TVGLFEATHGTAPKYAGQDKVNPGSLILS 369 D +SD A G +G+ P A+L + G++E HG+AP +G+ NP + ILS Sbjct 254 DILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISGKGLANPVAQILS 313 Query 370 AEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 MMLRY +G ++ A V + + +++K+ R + SQ G A+ + Sbjct 314 VAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCSQVGDAVCE 369 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola str. APS (Acyrthosiphon pisum)] Sequence ID: P56933.2 Length: 363 Range 1: 219 to 360 Score:64.7 bits(156), Expect:3e-10, Method:Compositional matrix adjust., Identities:40/145(28%), Positives:71/145(48%), Gaps:5/145(3%) Query 285 ITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSD-TVG 343 + + + D QI+ P ++ V+ NL GD ISD A G IG+ P A+ ++ G Sbjct 219 VHLSHLYIDNAAMQIIKDPNQFDVLLCSNLFGDIISDECATITGSIGMLPSASFNEKNFG 278 Query 344 LFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYD 402 L+E G+AP G++ NP + ILS M++RY + + AD + + + ++ T D Sbjct 279 LYEPAGGSAPDIEGKNIANPIAQILSLSMLVRYGMNLNQIADKIDKAVNNVLKKGYRTSD 338 Query 403 FARLMTGAKEVSTSQFGKAIIKHIL 427 + + T + G I+ ++ Sbjct 339 ISH---DNNFLKTDEMGDLIVDSLI 360 >RecName: Full=Isopropyl malate dehydrogenase htyC; AltName: Full=L-homotyrosine biosynthetic cluster protein C [Aspergillus rugulosus] Sequence ID: K0E689.1 Length: 366 Range 1: 90 to 314 Score:64.3 bits(155), Expect:4e-10, Method:Compositional matrix adjust., Identities:61/265(23%), Positives:106/265(40%), Gaps:56/265(21%) Query 128 LRQQLDLYVCLRPVRYFTGVPSPV-----KTPEKVNMVIFRENSEDIYAGIEWPA-GSPE 181 LR+ LD + LRPV++ + + + +++I RE + IY G G+ Sbjct 90 LRKALDAFGNLRPVKFIHPILTETSALKEQVCRGADLLIIRELTGGIYYGARQEHDGTLN 149 Query 182 AVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKG 241 A ++ + + R T + +P + +T + K Sbjct 150 AASDLDHYERAQVQRVARLAGTLAMSTQPPTP---------------------ITSLDKA 188 Query 242 NIMKFTEGAFKDWGYEVAVKEFGAKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILL 301 N++ ++ E +EF + +K ++ D + Sbjct 189 NLLAACGRLWRGVVEETIRREF-------------------PDVELKHMLIDTAAMTLGC 229 Query 302 RPAEYS-VIATLNLNGDYISDALAAEVGGIGIAPGANLSD---------TVGLFEATHGT 351 RP + + ++ T N+ GD ISD +A G +G+ P A+L G++E HG+ Sbjct 230 RPTKLNGIVLTSNMFGDIISDQASAIPGSLGLLPSASLCAIPGGESGGCVHGIYEPVHGS 289 Query 352 APKYAGQDKVNPGSLILSAEMMLRY 376 AP AGQ +NP +ILS MMLRY Sbjct 290 APDIAGQGIINPTGMILSVAMMLRY 314 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Buchnera aphidicola (Uroleucon sonchi)] Sequence ID: Q9EVI7.1 Length: 364 Range 1: 219 to 342 Score:63.9 bits(154), Expect:6e-10, Method:Compositional matrix adjust., Identities:40/124(32%), Positives:63/124(50%), Gaps:2/124(1%) Query 284 KITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGANLSDT-V 342 + + + D QI+ P ++ V+ NL GD ISD A G IG+ P A+L++ Sbjct 219 NVHLSHLYIDNATMQIIKDPNQFDVLLCSNLFGDIISDECAIITGSIGMLPSASLNEKKF 278 Query 343 GLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTY 401 GL+E G+AP G++ NP + ILS M++RY + K AD + + ++ T Sbjct 279 GLYEPAGGSAPDIEGKNIANPIAQILSVSMLVRYSMNLKNIADKIDYSVISILKKGYKTA 338 Query 402 DFAR 405 D A Sbjct 339 DIAH 342 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819] Sequence ID: Q9PLW0.1 Length: 358 Range 1: 6 to 350 Score:62.8 bits(151), Expect:1e-09, Method:Compositional matrix adjust., Identities:96/399(24%), Positives:165/399(41%), Gaps:67/399(16%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG VMK + + E+ E G + YG L DET Sbjct 6 VAVLAGDGIG---PLVMKEALKILTFIAQKYNFSFEFNEAKIGGASIDAYGV--ALSDET 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGV--PS 149 L+ ++ + G + P + R+ + LR+ +L+ LRP + + + S Sbjct 61 LKLCEQSDAILFGSVGGPKWDNLPIDQRPERASLLPLRKHFNLFANLRPCKIYESLTHAS 120 Query 150 PVKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P+K + V+++ RE + IY G + ++G + + Sbjct 121 PLKNEIIQKGVDILCVRELTGGIYFG-----------------KQDLG-------KESAY 156 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAK 266 + +K+ R+ R A + A + V L+ K N++ + + +E A Sbjct 157 DTEIYTKKEIERIARIAFESARIRKK-KVHLIDKANVLASS----------ILWREVVAN 205 Query 267 PLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAE 326 K Q I ++ + D QI+ P+ + V+ NL GD +SD LAA Sbjct 206 V-----------AKDYQDINLEYMYVDNAAMQIVKNPSIFDVMLCSNLFGDILSDELAAI 254 Query 327 VGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAADL 385 G +G+ A+L+D GL+E G+AP A + NP + ILSA +ML+Y +E A Sbjct 255 NGSLGLLSSASLNDKGFGLYEPAGGSAPDIAHLNIANPIAQILSAALMLKYSFKEEQA-- 312 Query 386 VVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 Q IE AI + + ++T + G I++ Sbjct 313 -AQDIENAISLALAQGKMTKDLNAKSYLNTDEMGDCILE 350 >RecName: Full=3-isopropylmalate dehydrogenase; AltName: Full=3-IPM-DH; AltName: Full=Beta-IPM dehydrogenase; Short=IMDH [Campylobacter jejuni RM1221] Sequence ID: Q5HS77.1 Length: 358 Range 1: 6 to 350 Score:62.8 bits(151), Expect:2e-09, Method:Compositional matrix adjust., Identities:98/401(24%), Positives:166/401(41%), Gaps:71/401(17%) Query 39 IPFIEGDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDET 98 + + GDGIG VMK + S E+ E G + YG L DET Sbjct 6 VAVLAGDGIG---PLVMKEALKILTFISQKYNFSFEFNEAKIGGASIDAYGV--ALSDET 60 Query 99 LEAIKEYQVAIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRYFTGV--PS 149 L+ ++ + G + P + R+ + LR+ +L+ LRP + + + S Sbjct 61 LKLCEQSDAILFGSVGGPKWDNLPIDQRPERASLLPLRKHFNLFANLRPCKIYESLTHAS 120 Query 150 PVKTP---EKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGI 206 P+K + V+++ RE + IY G + ++G + + Sbjct 121 PLKNEIIQKGVDILCVRELTGGIYFG-----------------KQDLG-------KESAY 156 Query 207 GIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVA--VKEFG 264 + +K+ R+ A + A + V L+ K N++ + W VA VK++ Sbjct 157 DTEIYTKKEIERIAHIAFESARIRKK-KVHLIDKANVL----ASSILWREVVANVVKDY- 210 Query 265 AKPLDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALA 324 Q I ++ + D QI+ P+ + V+ NL GD +SD LA Sbjct 211 ------------------QDINLEYMYVDNAAMQIVKNPSIFDVMLCSNLFGDILSDELA 252 Query 325 AEVGGIGIAPGANLSDT-VGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRYLGWKEAA 383 A G +G+ A+L+D GL+E G+AP A + NP + ILSA +ML+Y +E A Sbjct 253 AINGSLGLLSSASLNDKGFGLYEPAGGSAPDIAHLNIANPIAQILSAALMLKYSFKEEQA 312 Query 384 DLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGKAIIK 424 Q IE AI + + ++T + G I++ Sbjct 313 ---AQDIENAISLALAQGKMTKDLNAKSYLNTDEMGDCILE 350 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Zygosaccharomyces rouxii CBS 732] Sequence ID: Q96WI0.1 Length: 362 Range 1: 239 to 357 Score:60.1 bits(144), Expect:1e-08, Method:Compositional matrix adjust., Identities:44/126(35%), Positives:68/126(53%), Gaps:14/126(11%) Query 308 VIATLNLNGDYISDALAAEVGGIGIAPGANLS------DTVGLFEATHGTAPKYAGQDKV 361 ++ T NL GD ISD + G +G+ P A+L+ + GL+E HG+AP + KV Sbjct 239 IVLTSNLFGDIISDEASVIPGSLGLLPSASLASLPDTNEAFGLYEPCHGSAPDLP-KGKV 297 Query 362 NPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIESKTVTYDFARLMTGAKEVSTSQFGK 420 NP ++ILSA MML+ L + + V + ++ ++S T D G+ STS+ G Sbjct 298 NPIAMILSAAMMLKLSLNLSKEGEAVEKAVKQVLDSGVRTGDLG----GSN--STSEVGD 351 Query 421 AIIKHI 426 AI K + Sbjct 352 AIAKAV 357 >RecName: Full=3-isopropylmalate dehydrogenase; Short=3-IPM-DH; Short=IMDH; AltName: Full=Beta-IPM dehydrogenase [Zygosaccharomyces bailii] Sequence ID: Q9P3Y0.1 Length: 362 Range 1: 214 to 357 Score:58.9 bits(141), Expect:2e-08, Method:Compositional matrix adjust., Identities:46/151(30%), Positives:79/151(52%), Gaps:15/151(9%) Query 284 KITIKDVIADAFLQQILLRPAEYS-VIATLNLNGDYISDALAAEVGGIGIAPGANLS--- 339 ++T+K + D+ ++ P + + +I T N+ D ISD + G +G+ P A+L+ Sbjct 214 QLTVKHQLIDSAAMILIKNPTQLNGIIITSNMFEDIISDEASVIPGSLGLLPSASLASLP 273 Query 340 ---DTVGLFEATHGTAPKYAGQDKVNPGSLILSAEMMLRY-LGWKEAADLVVQGIEGAIE 395 + GL+E HG+AP + KVNP ++ILSA MML+ L + + + ++ ++ Sbjct 274 DTNEAFGLYEPCHGSAPDLP-KGKVNPVAMILSAAMMLKLSLNMAKEGEALETAVKQVLD 332 Query 396 SKTVTYDFARLMTGAKEVSTSQFGKAIIKHI 426 S T D G+ STS+ G AI K + Sbjct 333 SGVRTGDLG----GSN--STSEVGDAIAKAV 357 >RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic; AltName: Full=Cytosolic NADP-isocitrate dehydrogenase 1; AltName: Full=IDH 1; AltName: Full=IDP 1; AltName: Full=NADP(+)-specific ICDH 1; AltName: Full=Oxalosuccinate decarboxylase 1 [Dictyostelium discoideum] Sequence ID: Q75JR3.1 Length: 412 Range 1: 64 to 384 Score:45.4 bits(106), Expect:7e-04, Method:Compositional matrix adjust., Identities:76/338(22%), Positives:133/338(39%), Gaps:43/338(12%) Query 101 AIKEYQVAIKGPLTTPVGGGI---------RSLNVALRQQLDLYVCLRPVRYFTGVPSPV 151 AIK +V IK TP + +S N +R L + P+ VP V Sbjct 64 AIKRLKVGIKCATITPDEARVTEFGLKEMWKSPNGTIRNTLGGTLFREPI-VCKNVPRLV 122 Query 152 KTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIR---FPETAGIGI 208 K ++VI R D Y ++ ++L + +K + FP G+ + Sbjct 123 TCWNK-SIVIGRHAFGDQYRATDFVVKGAGKLELTYTPADGSAPQKFQVFDFPSDGGVAL 181 Query 209 KPVSKEGTSR-LVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVKEFGAKP 267 + + + + +++D + + L K I+K +G FKD E+ +E+ K Sbjct 182 GMYNTDASIKEFAYACFNFSLDK-KWPLYLSTKNTILKRYDGRFKDIFQEIYEREYKVKF 240 Query 268 LDGGPWHVFENPKTGQKITIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEV 327 G W+ + I D++A A ++ V A N +GD SDA+A Sbjct 241 DTAGIWY--------EHRLIDDMVAYA------MKSEGGFVWACKNYDGDVQSDAVAQGY 286 Query 328 GGIGIAPGANLSDTVGLFEATHGTAPKYAGQDK------VNPGSLILSAEMMLRYLGWKE 381 G +G+ LS + EA+HGT ++ + + N + I + L Y + Sbjct 287 GSLGLMTSVLLSADSLVAEASHGTVTRHFREHQKGRETSTNSIASIFAWTRGLEYRAKLD 346 Query 382 AADLVVQGIEG-------AIESKTVTYDFARLMTGAKE 412 D +++ A+ES +T D A + G+ E Sbjct 347 NNDKLLKFCHALEASCIDAVESGFMTKDLAICVKGSVE 384