1 50 ENO1_CANAL .......... .......... .......... .......... .......... ENO1_YEAST .......... .......... .......... .......... .......... ENO_CLAHE .......... .......... .......... .......... .......... ENO11_SCHPO .......... .......... .......... .......... .......... ENOA_ANAPL .......... .......... .......... .......... .......... ENOG_HUMAN .......... .......... .......... .......... .......... ENO_DROME MSWTASVFLR TSTTSMKFLR LRWPLPRIPQ NKSANVAPRF RSKSAVSQLS ENO_HOMGA .......... .......... .......... .......... .......... ENO_SCHJA .......... .......... .......... .......... .......... ENO1_MAIZE .......... .......... .......... .......... .......... ENO_NEOFR .......... .......... .......... .......... .......... Q9NDH8_TRYBB .......... .......... .......... .......... .......... ENO_BACSU .......... .......... .......... .......... .......... ENO_ENTHR .......... .......... .......... .......... .......... ENO_ECOLI .......... .......... .......... .......... .......... ENO_SHIFL .......... .......... .......... .......... .......... ENO_ZYMMO .......... .......... .......... .......... .......... Alignment .......... .......... .......... .......... .......... Domain .......... .......... .......... .......... .......... Secondary .......... .......... .......... .......... .......... FunctionalAA .......... .......... .......... .......... .......... 51 100 ENO1_CANAL .......... ......MSYA TKIHARYVYD SRGNPTVEVD FTTDKG.LFR ENO1_YEAST .......... ........AV SKVYARSVYD SRGNPTVEVE LTTEKG.VFR ENO_CLAHE .......... .......MPI SKIHSRYVYD SRGNPTVEVD IVTETG.LHR ENO11_SCHPO .......... .......MAI QKVFARQIYD SRGNPTVEVD LTTETG.IHR ENOA_ANAPL .......... ........SI LKIHAREIFD SRGNPTVEVD LYTNKG.LFR ENOG_HUMAN .......... ........SI EKIWAREILD SRGNPTVEVD LYTAKG.LFR ENO_DROME SGFKFVQIRK STCDSNEMTI KAIKARQIYD SRGNPTVEVD LTTELG.LFR ENO_HOMGA .......... ........SI TKVFARTIFD SRGNPTVEVD LYTSKG.LFR ENO_SCHJA .......... .......MAI IAIHARQIFD SRGNPTVEVD LKTAKG.LFR ENO1_MAIZE .......... .....MAVTI TWVKARQIFD SRGNPTVEVD VGLSDGSYAR ENO_NEOFR .......... .......MAI TKVHARQIFD SRGNPTVEVE VTTDKG.LFR Q9NDH8_TRYBB .......... .......MTI QKVHGREVLD SRGNPTVEVE VTTERG.VFR ENO_BACSU .......... .......PYI VDVYAREVLD SRGNPTVEVE VYTETGAFGR ENO_ENTHR .......... ......MSII TDVYAREILD SRGNPTIEVE VYTESGAFGR ENO_ECOLI .......... .......SKI VKIIGREIID SRGNPTVEAE VHLEGGFVGM ENO_SHIFL .......... .......SKI VKIIGREIID SRGNPTVEAE VHLEGGFVGM ENO_ZYMMO .......... ......MTAI VSIHGRQVVD SRGNPTVEVD VTLEDGSFGR Alignment .......... .........L LLLLLAAAAA AAAAAAAAAA ALLLLLLLLA Domain .......... .......... .......... .......... .......... Secondary .......... .........S SSS..SSSS. ....SSSSSS SSS....SSS FunctionalAA .......... .......... .......... .......... .......... 101 150 ENO1_CANAL SIVPSGASTG VHEALELRDG DKSKWLGKGV LKAVANVNDI IAPALIKAKI ENO1_YEAST SIVPSGASTG VHEALEMRDG DKSKWMGKGV LHAVKNVNDV IAPAFVKANI ENO_CLAHE AIVPSGASTG SHEACELRDG DKSKWAGKGV TKAVANVNEI IAPALIKENL ENO11_SCHPO AIVPSGASTG IWEALEMRDG DKTKWGGKGV LKAVGNVNNI IAPAVVKANL ENOA_ANAPL AAVPSGASTG IYEALELRDN DKTRYMGKGV SKAVEHINKT IAPALISKNV ENOG_HUMAN AAVPSGASTG IYEALELRDG DKQRYLGKGV LKAVDHINST IAPALISSGL ENO_DROME AAVPSGASTG VHEALELRDN DKANYHGKSV LKAVGHVNDT LGPELIKANL ENO_HOMGA AAVPSGASTG VHEALEMRDG DKSKYHGKSV FNAVKNVNDV IVPEIIKSGL ENO_SCHJA AAVPSGASTG VHEALELRDT NSKAYMCKGV LTAVSNVNNI IAPALLKKQI ENO1_MAIZE GAVPSGASTG IYEALELRDG G.SDYLGKGV LKAVSNVNNI IGPAIVGK.. ENO_NEOFR AAVPSGASTG VHEALELRDG IKADYVGKGV LKAVENVNKT IAPALVAANL Q9NDH8_TRYBB SAVPSGASTG VYEACELRDG DKKRYVGKGC LQAVKNVNEV IGPALIGR.. ENO_BACSU ALVPSGASTG EYEAVELRDG DKDRYLGKGV LTAVNNVNEI IAPELLGF.. ENO_ENTHR GMVPSGASTG EYEAVELRDG DKARYGGKGV TKAVDNVNNI IAEAIIGY.. ENO_ECOLI AAAPSGASTG SREALELRDG DKSRFLGKGV TKAVAAVNGP IAQALIGK.. ENO_SHIFL AAAPSGASTG SREALELRDG DKSRFLGKGV TKAVAAVNGP IAQALIGK.. ENO_ZYMMO AAVPSGASTG VHEAVELRDG DKTRWGGKGV TKAVHAVNNE IANAIIGL.. Alignment AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA.... Domain .......... .......... .......... .......... .......... Secondary SS........ .......... ...HHHHH.H HHHHHHHHHH HHHHHH.... FunctionalAA .......... .......... .......... .......... .......... 151 200 ENO1_CANAL DVVDQAKIDE FLLS.LDGTP N.....KSKL GANAILGVSL AAANAAAAAQ ENO1_YEAST DVKDQKAVDD FLIS.LDGTA N.....KSKL GANAILGVSL AASRAAAAEK ENO_CLAHE DVKDQAAVDA FLNK.LDGTT N.....KTKI GANAILGVSM AVAKAAAAEK ENO11_SCHPO DVTDQKAADE FLLK.LDGTE N.....KSKL GANAILGVSM AICRAGAAQK ENOA_ANAPL NVVEQDKIDK LMLD.MDGSE N.....KSKF GANAILGVSL AVCKAGAAEK ENOG_HUMAN SVVEQEKLDN LMLE.LDGTE N.....KSKF GANAILGVSL AVCKAGAAER ENO_DROME DVVDQASIDN FMIK.LDGTE N.....KSKF GANAILGVSL AVAKAGAAKK ENO_HOMGA KVTQQKECDE FMCK.LDGTE N.....KSSL GANAILGVSL AICKAGAAEL ENO_SCHJA PVTNQSEVDQ FMIE.LDGKE N.....KGNL GANAILGVSL AVCKAGAAEL ENO1_MAIZE DPTEQVEIDN FMVQQLDGTS NEWGWCKQKL GANAILAVSL AVCKAGAMVK ENO_NEOFR DVKNQKAVDD FLLK.LDGTP N.....KSKL GANAILGVSL AVARAGAADK Q9NDH8_TRYBB DELKQEELDT LMLR.LDGTP N.....KGKL GANAILGCSM AISKAAAAAK ENO_BACSU DVTEQNAIDQ LLIE.LDGTE N.....KGKL GANAILGVSM ACARAAADFL ENO_ENTHR DVRDQMAIDK AMIA.LDGTP N.....KGKL GANAILGVSI AVARAAADYL ENO_ECOLI DAKDQAGIDK IMID.LDGTE N.....KSKF GANAILAVSL ANAKAAAAAK ENO_SHIFL DAKDQAGIDK IMID.LDGTE N.....KSKF GANAILAVSL ANAKAAAAAK ENO_ZYMMO EAEDQELIDQ TMIK.LDGTP N.....KGKF GANAILGVSL AVAKAAAEAR Alignment LLLLLLLLLL LLLL.AAAAA A.....AAAA AAAAAAAAAA AAAAAAAALL Domain .......... .......... .......... .......... .......... Secondary ...HHHHHHH HHHH.HHH.. .......... HHHHHHHHHH HHHHHHHHHH FunctionalAA .......... .......... .......... .......... .......... 201 250 ENO1_CANAL GIPLYKHIAN ISNAKKGKFV LPVPFQNVLN GGSHAGGALA FQEFMIAPTG ENO1_YEAST NVPLYKHLAD LSKSKTSPYV LPVPFLNVLN GGSHAGGALA LQEFMIAPTG ENO_CLAHE RVPLYAHISD LSGTKK.PFV LPVPFMNVVN GGSHAGGRLA FQEFMIVPSG ENO11_SCHPO KLPLWKYIAE NFGTKG.PYV LPVPSFNVLN GGSHAGGDLA FQEFMILPTG ENOA_ANAPL GVPLYRHIAD LAGNP..EVI LPVPAFNVIN GGSHAGNKLA MQEFMIPPCG ENOG_HUMAN ELPLYRHIAQ LAGNS..DLI LPVPAFNVIN GGSHAGNKLA MQEFMILPVG ENO_DROME GVPLYKHIAD LAGNK..EII LPVPAFNVIN GGSHAGNKLA MQEFMILPTG ENO_HOMGA GIPLYRHIAN LANYD..EVI LPVPAFNVIN GGSHAGNKLA MQEFMILPTG ENO_SCHJA NLPLYRYIAK LAGHK..DVI MPVPAFNVIN GGSHAGNKLA MQEFMILPTG ENO1_MAIZE KIPLYQHIAN LAGNK..TLV LPVPAFNVIN GGSHAGNKLA MQEFMILPTG ENO_NEOFR GVPLYQHLGE LAGNKG.PWI LPVPSMNVLN GGSHAGNKLA MQEFMILPTG Q9NDH8_TRYBB GVPLYRYLAS LAGTK..ELR LPVPCFNVIN GGKHAGNALP FQEFMIAPVK ENO_BACSU QIPLYQYLGG FN.....SKT LPVPMMNIVN GGEHADNNVD IQEFMIMPVG ENO_ENTHR EVPLYHYLGG FN.....TKV LPTPMMNIIN GGSHADNSID FQEFMIMPVG ENO_ECOLI GMPLYEHIAE LNGTPG.KYS MPVPMMNIIN GGEHADNNVD IQEFMIQPVG ENO_SHIFL GMPLYEHIAE LNGTPG.KYS MPVPMMNIIN GGEHADNNVD IQEFMIQPVG ENO_ZYMMO GLPLYRYVGG TA.....AHV LPVPMMNIVN GGMHADNPID FQEFMIAPVG Alignment LAAAALLLLL LLL....... AAAAAAAAAA AAAAALLLLL LAAAAAAAAA Domain .......... .......DDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD Secondary ..HHHHHHHH HHH....... ..SS.SSSSS .HHHH..... ..SSSSS... FunctionalAA .......... .......... .......... .......... .......... 251 300 ENO1_CANAL VSTFSEALRI GSEVYHNLKS LTKKKYGQSA GNVGDEGGVA PDIKTPKEAL ENO1_YEAST AKTFAEALRI GSEVYHNLKS LTKKRYGASA GNVGDEGGVA PNIQTAEEAL ENO_CLAHE APSFTEAMRQ GAEVYQKLKS LTKKRYGQSA GNVGDEGGVA PDIQTAEEAL ENO11_SCHPO APSFSEAMRW GAETYHTLKS IAKKRYGSSA GNVGDEGGIA PDLQTPQEAL ENOA_ANAPL ADSFKEAMRI GAEVYHNLKN VIKEKYGKDA TNVGDEGGFA PNILENKEAL ENOG_HUMAN AESFRDAMRL GAEVYHTLKG VIKDKYGKDA TNVGDEGGFA PNILENSEAL ENO_DROME ATSFTEAMKM GSEVYHHLKN VIKAKFGLDA TAVGDEGGFA PNIQSNKEAL ENO_HOMGA ATSFTEAMRM GTEVYHHLKA VIKARFGLDA TAVGDEGGFA PNILNNKDAL ENO_SCHJA ASSFTEAMQM GSEVYHNLKA VIKREFGLDA CNVGDEGGFA PNIQDNMKGL ENO1_MAIZE ASSFKEAMKM GVEVYHNLKS IIKKKYGQDA TNVGDEGGFA PNIQENKEGL ENO_NEOFR AKSFTEALKM GSEVYHALKS VIKAKYGQDA CNVGDEGGFA PNIQDNKEGL Q9NDH8_TRYBB ATSFSEALRM GSEVYHSLRG IIKKKYGQDA VNVGDEGGFA PPIKDINEPL ENO_BACSU APNFREALRM GAQIFHSLKS VLSAKG..LN TAVGDEGGFA PNLGSNEEAL ENO_ENTHR APTFKEALRM GAEVFHALAA ILKSRG..LA TSVGDEGGFA PNLGSNEEGF ENO_ECOLI AKTVKEAIRM GSEVFHHLAK VLKAKG..MN TAVGDEGGYA PNLGSNAEAL ENO_SHIFL AKTVKEAIRM GSEVFHHLAK VLKAKG..MN TAVGDEGGYA PNLGSNAEAL ENO_ZYMMO ASSINEAVRI GTEVFHTLKK ELSAKG..MN TNVGDEGGFA PSLDSASSAL Alignment LLLLLAAAAA AAAAAALLLL LLLLLL...L LLAAAAAAAA AAALLLLLLL Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD Secondary ..HHHHHHHH HHHHHHHHHH HHHHH..... .......... ....HHHHHH FunctionalAA .......... .......... .......... .......... .......... 301 350 ENO1_CANAL DLIMDAIDKA GYKG..KVGI AMDVASSEFY KDG..KYDL. D.FKNPESDP ENO1_YEAST DLIVDAIKAA GHDG..KVKI GLDCASSEFF KDG..KYDL. D.FKNPNSDK ENO_CLAHE DLITDAIEEA GYTG..QIKI AMDVASSEFY KADEKKYDL. D.FKNPDSDK ENO11_SCHPO DLIVEAINKA GYEG..KIKI GLDVASSEFY VDG..KYDL. D.IKAAKPKP ENOA_ANAPL ELLKTAIGKA GYSD..KVVI GMDVAASEFY ..RDGKYDL. D.FKSP.DDP ENOG_HUMAN ELVKEAIDKA GYTE..KIVI GMDVAASEFY ..RDGKYDL. D.FKSP.TDP ENO_DROME NLISDAIAKA GYTG..KIEI GMDVAASEFY ..KDGQYDL. D.FKNEKSDK ENO_HOMGA DLIQEAIKKA GYTG..KIEI GMDVAASEFY KQ.NNIYDL. D.FKTANNDG ENO_SCHJA QLLEEAIKIA GYTG..KVEI GMDCAASEYY ..KKGKYDL. D.FKNPQSAE ENO1_MAIZE ELLKAAIEKA GYTG..KVVI GMDVAASEFF GEKDKTYDL. N.FKEENNDG ENO_NEOFR ELLNEAIAKA GYTG..KVKI GMDVASSEFY ..KDGKYDL. D.FKNPNSDP Q9NDH8_TRYBB PILMEAIEEA GHRG..KFAI CMDCAASETY DEKKQQYNL. T.FKSP...E ENO_BACSU QTIVEAIEKA GFKPGEEVKL AMDAASSEFY NKEDGKYHL. .SGEG..... ENO_ENTHR EVIIEAIEKA GYVPGKDVVL AMDAASSEFY DKEKGVYVLA DSGEG..... ENO_ECOLI AVIAEAVKAA GYELGKDITL AMDCAASEFY K..DGKYVLA ..GEGN.... ENO_SHIFL AVIAEAVKAA GYELGKDITL AMDCAASEFY K..DGKYVLA ..GEGN.... ENO_ZYMMO DFIVDSISKA GYKPGEDVFI ALDAASSEFY NKDQNIYDLK ..GEG..... Alignment LLLLLLLLLA AALLLLLAAA AAAAAAAAAA ......AAA. LLLLL..... Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD Secondary HHHHHHHHHH ........SS SSS.HHHH.S S....SSSS. .......... FunctionalAA .......... .......... ..M....... .......... .......... 351 400 ENO1_CANAL SKWLSGPQLA DLYEQLISEY PIVSIEDPFA EDDWDAWVHF FERVGDKIQI ENO1_YEAST SKWLTGPQLA DLYHSLMKRY PIVSIEDPFA EDDWEAWSHF FKTAG..IQI ENO_CLAHE SKWITYEQLA DQYKQLAAKY PIVSIEDPFA EDDWEAWSYF YKTSGSDFQI ENO11_SCHPO ENKLTYQQLT DLYVELSKKY PIVSIEDPFD QDDWSAWTHM KAETD..FQI ENOA_ANAPL SRYISPDQLA DLYKGFVKNY PVVSIEDPFD QDDWGAWKKF TGSVG..IQV ENOG_HUMAN SRYITGDQLG ALYQDFVRDY PVVSIEDPFD QDDWAAWSKF TANVG..IQI ENO_DROME SQWLPADKLA NLYQEFIKDF PIVSIEDPFD QDHWEAWSNL TGCTD..IQI ENO_HOMGA SQKISGDQLR DMYMEFCKDF PIVSIEDPFD QDDWETWSKM TSGTT..IQI ENO_SCHJA SHWLSPDEMA NVYKEMIQKY PIVSIEDPFD QDDWDAWPKL TASTN..IQI ENO1_MAIZE SNKISGDSLK DLYKSFVSEY PIESIEDPFD QDDWSTYAKL TDEIGQKVQI ENO_NEOFR SKWISGEELG QFYKEITSEY PIVSIEDPYD QDDFESWSKF RADMQDKIQI Q9NDH8_TRYBB PTWVTAEQLR ETYCKWAHDY PIVSIEDPYD QDDFAGFAGI TEALKGKTQI ENO_BACSU .VVKTSAEMV DWYEELVSKY PIISIEDGLD ENDWEGHKLL TERLGKKVQL ENO_ENTHR ..EKTTDEMI KFYEELVSKY PIISIEDGLD ENDWDGFKKL TDVLGDKVQL ENO_ECOLI .KAFTSEEFT HFLEELTKQY PIVSIEDGLD ESDWDGFAYQ TKVLGDKIQL ENO_SHIFL .KAFTSEEFT HFLEELTKQY PIVSIEDGLD ESDWDGFAYQ TKVLGDKIQL ENO_ZYMMO .RKLTSAQLV DYYVELCGKY PIYSIEDGLA EDDFEGWKIL TEKLGDKVQL Alignment LLLLLLLLLL LLLLLLLLLA AAAAAAAAAA AAAALLLLLL LLLLLLLAAA Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD Secondary .SSSHHHHHH HHHHHHHHHH .SSSSS.... ..HHHHHHHH HHHHH...SS FunctionalAA .......... .......... .....M.... .......... .......... 401 450 ENO1_CANAL VGDDLTVTNP TRIKTAIEKK AANALLLKVN QIGTLTESIQ AANDSYAAGW ENO1_YEAST VADDLTVTNP KRIATAIEKK AADALLLKVN QIGTLSESIK AAQDSFAAGW ENO_CLAHE VGDDLTVTNP EFIKKAIETK ACNALLLKVN QIGTITEAIN AAKDSFAAGW ENO11_SCHPO VGDDLTVTNV KRLRTAIDKK CANALLLKVN QIGSVTESLN AVRMSYEAGW ENOA_ANAPL VGDDLTVTNP KRIAKAVEEK ACNCLLLKVN QIGSVTESLQ ACKLAQSNGW ENOG_HUMAN VGDDLTVTNP KRIERAVEEK ACNCLLLKVN QIGSVTEAIQ ACKLAQENGW ENO_DROME VGDDLTVTNP KRIATAVEKK ACNCLLLKVN QIGTVTESIA AHLLAKKNGW ENO_HOMGA VGDDLTVTNP KRITTAVEKK ACKCLLLKVN QIGSVTESID AHLLAKKNGW ENO_SCHJA VGDDLTVTNP KRIEKAIKVK ACNCLLLKVN QIGSITESIE ACKMAQKAGW ENO1_MAIZE VGDDLLVTNP TRVAKAINEK TCNALLLKVN QIGSVTESIE AVRMSKRAGW ENO_NEOFR VGDDLTVTNP KRIAMAIEKK ACNGLLLKVN QIGTVSESIQ AALDAFNDGW Q9NDH8_TRYBB VGDDLTVTNT ERIKMAIEKK ACNSLLLKIN QIGTISEAIA SSKLCMENGW ENO_BACSU VGDDLFVTNT KKLSEGIKNG VGNSILIKVN QIGTLTETFD AIEMAKRAGY ENO_ENTHR VGDDLFVTNT QKLSEGIEKG IANSILIKVN QIGTLTETFE AIEMAKEAGY ENO_ECOLI VGDDLFVTNT KILKEGIEKG IANSILIKFN QIGSLTETLA AIKMAKDAGY ENO_SHIFL VGDDLFVTNT KILKEGIEKG IANSILIKFN QIGSLTETLA AIKMAKDAGY ENO_ZYMMO VGDDLFVTNV KRLSDGIERG IANSLLVKFN QIGSLSETLA AVNMANDASY Alignment AAAAAAAAAL LLLLLLLLLL LLLLAAAAAA AAAAAAALLL LLLLLLLLAA Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD Secondary SS......HH HHHHHHHHH. ...SSSSHHH HH.HHHHHHH HHHHHHHHH. FunctionalAA ..M....... .......... .......... .......... .......... 451 500 ENO1_CANAL GVMVSHRSGE TEDTFIADLS VGLRSGQIKT GAPARSERLA KLNQILRIEE ENO1_YEAST GVMVSHRSGE TEDTFIADLV VGLRTGQIKT GAPARSERLA KLNQLLRIEE ENO_CLAHE GVMVSHRSGE TEDVTIADIV VGLRAGQIKT GAPARSERLA KLNQILRIEE ENO11_SCHPO GVMVSHRSGE TADTFISHLT VGIGAGQLKS GAPCRSERLA KYNELLRIEE ENOA_ANAPL GVMVSHRSGE TEDTFIADLV VGLCTGQIKT GAPCRSERLA KYNQLLRIEE ENOG_HUMAN GVMVSHRSGE TEDTFIADLV VGLCTGQIKT GAPCRSERLA KYNQLMRIEE ENO_DROME GTMVSHRSGE TEDSFIGDLV VGLSTGQIKT GAPCRSERLA KYNQILRIEE ENO_HOMGA GTMVSHRSGE TEDCFIADLV VGLCTGQIKT GAPCRSERLA KYNQILRIEE ENO_SCHJA GVMVSHRSGE TEDNFIADLV VGLCTGQIKT GAPCRSERLA KYNQLLRIEE ENO1_MAIZE GVMASHRSGE TEDTFIADLS VGLSTGQIKT GAPCRSERLA KYNQLLRIEE ENO_NEOFR GVMVSHRSGE TEDTFIADLV VGLKSGQIKT GAPCRSERLA KYNQLLRIEE Q9NDH8_TRYBB SVMVSHRSGE TEDTYIADLV VALGSGQIKT GAPCRGERTA KLNQLLRIEE ENO_BACSU TAVISHRSGE TEDSTIADIA VATNAGQIKT GAPSRTDRVA KYNQLLRIED ENO_ENTHR TAVVSHRSGE TEDSTISDIA VATNAGQIKT GSLSRTDRIA KYNQLLRIED ENO_ECOLI TAVISHRSGE TEDATIADLA VGTAAGQIKT GSMSRSDRVA KYNQLIRIEE ENO_SHIFL TAVISHRSGE TEDATIADLA VGTAAGQIKT GSMSRSDRVA KYNQLIRIEE ENO_ZYMMO TAVMSHRSGE TEDTTIADLA VATNCGQIKT GSLCRSERIA KYNQLMRIEE Alignment AAAAAAAAAA AAAAAAAAAA ALLLLAAAAA ALLLAAAAAA AAAAAAAAAA Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD Secondary SSSSS..... ...HHHHHHH HH...SSSS. ....HHHHHH HHHHHHHHHH FunctionalAA ....BBBB.. .......... .......... .......... .......... 501 523 ENO1_CANAL ELGSEAIYAG KDFQKASQL. ... ENO1_YEAST ELGDNAVFAG ENFHHGDKL. ... ENO_CLAHE ELGDKAVYAG DNFRTAINL. ... ENO11_SCHPO ELGSEGVYAG AHAGKYIKAA KF. ENOA_ANAPL ELGSKARFAG RNFRNPRIN. ... ENOG_HUMAN ELGDEARFAG HNFRNPSVL. ... ENO_DROME EIGAGVKFAG KSFRKPQ... ... ENO_HOMGA ELGSGAKFAG KNFRAPS... ... ENO_SCHJA ELGSTAKYAG KHFRHPQI.. ... ENO1_MAIZE ELGDAAVYAG AKFRAPVEPY ... ENO_NEOFR ELGANATYAG ENFRRPF... ... Q9NDH8_TRYBB ELGAHAK... ......FGFP GWS ENO_BACSU QLAETAQYHG INSFYNLNK. ... ENO_ENTHR QLGEVAEYKG LKSFYNLKAA ... ENO_ECOLI ALGEKAPYNG RKEIKGQA.. ... ENO_SHIFL ALGEKAPYNG RKEIKGQA.. ... ENO_ZYMMO ELGSVAKYAG RSVLRKAK.. ... Alignment AAALLLLLLL .......... ... Domain DDDDDDDDDD DDDDDDD... ... Secondary HHHHHH..HH HHHH...... ... FunctionalAA .......... .......... ...