RID: 0YWCK21T013 Job Title:Protein Sequence Program: BLASTP Query: unnamed protein product ID: lcl|Query_12482141(amino acid) Length: 1714 Database: swissprot Non-redundant UniProtKB/SwissProt sequences Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=Reverse gyrase; Contains: RecName: Full=Pko r-Gy... Thermococcus... NA 69014 3143 3143 100% 0.0 88.37 1711 Q6F598.1 RecName: Full=Reverse gyrase; Contains: RecName: Full=Pho r-Gy... Pyrococcus h... NA 70601 2363 2363 99% 0.0 69.70 1624 O58530.1 RecName: Full=Reverse gyrase [Pyrococcus furiosus DSM 3638] Pyrococcus f... NA 186497 1439 1831 71% 0.0 73.15 1214 P95479.2 RecName: Full=Reverse gyrase [Pyrococcus abyssi GE5] Pyrococcus a... NA 272844 1397 1789 71% 0.0 72.42 1214 Q9UZ86.1 RecName: Full=Reverse gyrase; Contains: RecName: Full=Mja r-Gy... Methanocaldo... NA 243232 1330 1330 99% 0.0 45.21 1613 Q58907.1 RecName: Full=Reverse gyrase 1 [Aeropyrum pernix K1] Aeropyrum pe... NA 272557 715 922 75% 0.0 41.64 1370 Q9YCB6.2 RecName: Full=Reverse gyrase [Pyrobaculum aerophilum str. IM2] Pyrobaculum ... NA 178306 701 918 71% 0.0 41.52 1228 Q8ZXT5.1 RecName: Full=Reverse gyrase 1 [Aquifex aeolicus VF5] Aquifex aeol... NA 224324 662 864 71% 0.0 40.90 1146 O67037.1 RecName: Full=Reverse gyrase 2 [Sulfurisphaera tokodaii str. 7] Sulfurisphae... NA 273063 628 848 72% 0.0 38.58 1233 Q975P6.2 RecName: Full=Reverse gyrase 1; AltName: Full=TopR1... Saccharolobu... NA 273057 622 825 71% 0.0 38.23 1242 Q97ZZ8.1 RecName: Full=Reverse gyrase 1 [Sulfolobus acidocaldarius DSM... Sulfolobus a... NA 330779 598 784 74% 0.0 36.96 1248 Q08582.3 RecName: Full=Reverse gyrase [Archaeoglobus fulgidus DSM 4304] Archaeoglobu... NA 224325 593 792 69% 0.0 40.07 1054 O29238.1 RecName: Full=Reverse gyrase 2 [Aquifex aeolicus VF5] Aquifex aeol... NA 224324 585 791 70% 0.0 38.86 1159 O67226.2 RecName: Full=Reverse gyrase 2 [Aeropyrum pernix K1] Aeropyrum pe... NA 272557 558 752 70% 1e-172 37.04 1215 Q9YC75.2 RecName: Full=Reverse gyrase; Short=TtRG [Caldanaerobacter... Caldanaeroba... NA 273068 525 697 73% 2e-161 35.78 1117 Q8R979.1 RecName: Full=Reverse gyrase [Thermotoga maritima MSB8] Thermotoga m... NA 243274 516 702 79% 3e-158 36.00 1104 O51934.1 RecName: Full=Reverse gyrase subunit B; AltName:... Methanopyrus... NA 190192 509 556 51% 1e-154 36.87 1221 F1SVH1.1 RecName: Full=Reverse gyrase 2; Short=RG2; AltName: Full=TopR2... Saccharolobu... NA 273057 507 685 71% 3e-154 33.64 1166 Q97ZF5.1 RecName: Full=Reverse gyrase [Saccharolobus shibatae B12] Saccharolobu... NA 523848 498 673 71% 6e-151 32.89 1166 P74759.1 RecName: Full=Reverse gyrase 1 [Sulfurisphaera tokodaii str. 7] Sulfurisphae... NA 273063 474 652 71% 1e-142 33.27 1156 Q971T7.1 RecName: Full=Reverse gyrse subunit B; AltName:... Nanoarchaeum... NA 228908 455 455 34% 2e-142 43.53 575 Q74M79.1 RecName: Full=Reverse gyrase 2 [Sulfolobus acidocaldarius DSM... Sulfolobus a... NA 330779 463 629 71% 2e-138 33.06 1153 P0DW67.1 RecName: Full=Reverse gyrase subunit A; AltName:... Nanoarchaeum... NA 228908 365 610 36% 2e-108 51.66 701 Q74MA4.1 RecName: Full=Reverse gyrase subunit A; AltName:... Methanopyrus... NA 190192 215 261 18% 2e-60 44.85 358 Q8TYK7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Campylobacte... NA 192222 129 129 19% 5e-29 31.07 700 Q9PLZ2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Halalkalibac... NA 272558 122 122 21% 7e-27 30.03 690 Q9KA23.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 176279 119 211 33% 6e-26 30.74 689 Q5HPU2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia f... NA 315456 119 119 20% 8e-26 27.68 776 Q4UM42.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia p... NA 272947 119 119 20% 8e-26 28.20 776 Q9ZDK2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia t... NA 257363 118 118 20% 1e-25 27.94 779 Q68X45.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia c... NA 272944 118 118 20% 2e-25 27.68 776 Q92IH1.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Synechococcu... NA 1140 118 118 20% 2e-25 30.37 883 P34185.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Aquifex aeol... NA 224324 115 115 15% 4e-25 33.94 540 O66893.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Synechocysti... NA 1111708 117 117 20% 5e-25 29.13 898 P73810.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 273036 115 218 33% 1e-24 32.96 689 Q2YXL8.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pyrococcus f... NA 186497 116 116 16% 1e-24 31.42 1060 O73954.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 282459 115 218 33% 1e-24 32.96 689 Q6G9W3.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 1280 115 217 33% 1e-24 32.96 689 Q06AK7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Thermotoga m... NA 243274 114 228 34% 1e-24 30.68 633 P46799.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 367830 114 216 33% 3e-24 32.96 689 Q2FHI8.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Rickettsia b... NA 336407 114 114 20% 3e-24 28.46 800 Q1RIM1.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Xylella fast... NA 183190 114 204 33% 3e-24 30.03 815 Q87AQ6.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Zymomonas mo... NA 264203 114 114 19% 3e-24 29.36 1212 Q9X3X7.3 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Xylella fast... NA 160492 113 203 33% 6e-24 29.74 815 Q9PEV8.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Helicobacter... NA 85962 112 112 18% 8e-24 30.24 736 P55991.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Methanocaldo... NA 243232 112 112 19% 1e-23 27.54 761 Q59046.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 279808 112 218 33% 1e-23 30.11 689 Q4L5V2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Fervidobacte... NA 2423 111 111 15% 2e-23 32.23 699 O34204.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Lactococcus ... NA 272623 111 219 34% 2e-23 30.82 710 Q9CG80.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pasteurella ... NA 272843 111 111 18% 2e-23 31.59 868 Q9CN30.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Helicobacter... NA 85963 111 111 18% 3e-23 30.45 736 Q9ZMV7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Treponema pa... NA 243276 110 110 15% 3e-23 32.83 731 O83409.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Haemophilus ... NA 71421 111 111 18% 3e-23 29.68 868 P43012.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Streptomyces... NA 100226 108 108 20% 2e-22 27.59 952 Q9X909.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Escherichia ... NA 83333 107 107 21% 6e-22 28.47 865 P06612.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Bacillus sub... NA 224308 105 105 18% 1e-21 30.15 691 P39814.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Pseudomonas ... NA 208964 105 105 18% 2e-21 28.57 868 Q9HZJ5.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Salmonella e... NA 99287 103 103 18% 5e-21 31.29 865 P0A2I1.1 RecName: Full=DNA topoisomerase I, plasmid; AltName:... Xylella fast... NA 160492 100 100 18% 3e-20 27.41 660 Q9PHK2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Staphylococc... NA 342451 100 100 18% 4e-20 28.96 688 Q49X35.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Vibrio chole... NA 243277 100 100 18% 7e-20 28.90 876 Q9KRB2.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycoplasmoid... NA 710127 95.1 95.1 19% 2e-18 27.22 719 Q9JN65.2 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Buchnera aph... NA 107806 92.8 92.8 20% 1e-17 26.74 861 P57371.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Buchnera aph... NA 198804 91.7 91.7 18% 3e-17 26.97 853 Q8K9P7.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycolicibact... NA 246196 90.1 90.1 15% 1e-16 28.57 936 A0R5D9.1 RecName: Full=Elongation factor 2; Short=EF-2; Contains:... Methanopyrus... NA 190192 90.1 90.1 29% 1e-16 27.24 1257 Q8TXJ4.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycoplasmoid... NA 272634 87.8 87.8 7% 5e-16 38.52 711 P78032.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycoplasmoid... NA 243273 86.7 86.7 14% 1e-15 27.54 709 P47368.1 RecName: Full=DNA topoisomerase 1 type prokaryotic [Acanthamoe... Acanthamoeba... NA 212035 83.6 83.6 15% 9e-15 24.53 854 Q5UQB5.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Mycobacteriu... NA 272631 82.8 82.8 15% 2e-14 28.16 947 O69548.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA... Borreliella ... NA 224326 82.8 82.8 15% 2e-14 28.82 848 O51768.1 RecName: Full=Probable translation initiation factor IF-2;... Thermococcus... NA 69014 80.9 80.9 28% 8e-14 25.88 1144 Q5JGR9.1 RecName: Full=Probable translation initiation factor IF-2;... Pyrococcus h... NA 70601 68.9 68.9 28% 3e-10 23.12 1044 O58822.1 RecName: Full=Probable translation initiation factor IF-2;... Methanocaldo... NA 243232 67.4 67.4 29% 1e-09 23.00 1155 Q57710.1 RecName: Full=Replicative DNA helicase DnaB; AltName: Full=DNA... Rhodothermus... NA 29549 55.1 55.1 29% 6e-06 22.41 941 O30477.1 RecName: Full=Probable translation initiation factor IF-2;... Pyrococcus a... NA 272844 50.8 97.4 10% 1e-04 38.46 992 Q9UZK7.1 RecName: Full=DNA topoisomerase 3-beta [Oryza sativa Japonica... Oryza sativa... Japanese rice 39947 48.1 48.1 19% 8e-04 23.64 866 Q0J0S6.1 Alignments: >RecName: Full=Reverse gyrase; Contains: RecName: Full=Pko r-Gyr intein [Thermococcus kodakarensis KOD1] Sequence ID: Q6F598.1 Length: 1711 Range 1: 1 to 1711 Score:3143 bits(8150), Expect:0.0, Method:Compositional matrix adjust., Identities:1512/1711(88%), Positives:1628/1711(95%), Gaps:0/1711(0%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 MKA+YREMCPNC GRISDERL+ +NPC+ECLDEPVHADSYF+L++AVRNALK++GTLKEW Sbjct 1 MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEW 60 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 E+IY LE REIE FF++ATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA Sbjct 61 EKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQ 180 VWHA KGKKSYIVVPTTPLVIQTVRKI+ + E A ++ LAYYHGNLRKKEKEEML +I+ Sbjct 121 VWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIK 180 Query 181 GEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIG 240 EDYDILVTSAQW+AR ++EVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGF D+II Sbjct 181 NEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQ 240 Query 241 KAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATG 300 KAWEII+LKKQMS+YLNG ++DR EKL LN EI +LQREIE+FKR+NKIGIMIIASATG Sbjct 241 KAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATG 300 Query 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPI 360 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPT+DIK HVEELLT LGKGG+IF P+ Sbjct 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPV 360 Query 361 DQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLP 420 DQGLGYAEEL NYL E+GF++ELVSSKNKKA+E+FENGEADYL+GSATYYGSLVRG+DLP Sbjct 361 DQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLP 420 Query 421 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRN 480 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLS+EDR+QAEKLHARLRRLIRN Sbjct 421 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRN 480 Query 481 IPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLT 540 IPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLR+ L DEEVL+KLAEDPF+SL Sbjct 481 IPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLV 540 Query 541 EEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEF 600 +EEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEF Sbjct 541 KEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEF 600 Query 601 KMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFF 660 KMVPFEELDLDEIL+QIDEDREKVRLVMEGKISAKVKDLV+SALMIVESPNKARTIANFF Sbjct 601 KMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFF 660 Query 661 GQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYD 720 GQPSKTRIGDLVAYE+S+G+ MLTILASGGHMFDLVTNEGYHGV+IQN+G+MLKFIPVYD Sbjct 661 GQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYD 720 Query 721 TIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGE 780 T+KRCRDCGHQFVDWE+KGVCPRCGSTNVRDAL+NV AMRE+AQEVDEILIATDPDTEGE Sbjct 721 TLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGE 780 Query 781 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGF 840 KIAWDIRNVL+PYTPNIKRIEFHEVTRPAIMKAIQEARDVNE RVNAQIVRRIEDRWIGF Sbjct 781 KIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGF 840 Query 841 ELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQFTVEIGKD 900 ELSQELQRVFE+ NLSAGRVQTPVLGWIIERYKEF+ESE YFLGLTLENGLQ T+E+GKD Sbjct 841 ELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKD 900 Query 901 GKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL 960 GK+VEPPEYVTVE+V+LEE+E NP PPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL Sbjct 901 GKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL 960 Query 961 CVTPDTLVSLSDGRIMEIKEAVEGSEGNLLAVNGLKPKEAKALKFWEIDWNGPLKVIKLK 1020 CVTPDTLVSL+DGRIMEIK+AVE SEGNLL+VNGLKPKEAKALKFWEIDWNGPLKVIKLK Sbjct 961 CVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLK 1020 Query 1021 NGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVAFAYNTGHRGREEYTLLNLLIKLGI 1080 NGHEIKATPDHGLLVMR+GKLGWVSAKN+REGDYVAFAYNTGHRGR+EYTLL L+IKLGI Sbjct 1021 NGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGI 1080 Query 1081 TDVMVEVDEEYFNEKVAPIIKERIPTSTKYKYLRRYVLPLHLLQEWRIDDYETHVKSLYR 1140 TDVMVE+DEEYFNEKVAPI++ERI TSTKYKYLRR VLPL+LLQEW +DDYE HVKSLYR Sbjct 1081 TDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYR 1140 Query 1141 QRAGSKPIPNFKLDERFWYVFGLVLGDGTLRNSKVLISQTPLKDVKSVLKEVFPFLYVFE 1200 QRAGSKPIPNFKLD RFWYVFGLVLGDGTLR+SKVLISQTPLKDVKSVL++VFPFL VFE Sbjct 1141 QRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFE 1200 Query 1201 TTTQVGFSNSILAEVFRRLGAREGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNGRKG 1260 TT QVGFSNSI+AEVFRRLGAR+GKLHPLVFGLREEYINAMIAGYFDTDGTFSILN RKG Sbjct 1201 TTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKG 1260 Query 1261 PNFRAILTSKRGDVLRMLSVYLYQVGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYL 1320 PNFR ILTSKRGDVLRMLSVYLYQ+GIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYL Sbjct 1261 PNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYL 1320 Query 1321 RIRRRQFEEAYSVYRSSRRAFEEDLLPVASIFRKLKFRNGVKNRILKETGIDIWNWLKRL 1380 RIRR QF+EAYSVYR+SRRAFE DLLPVA +F KLKF+NG KNRILKETGID+WNWLKR Sbjct 1321 RIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRP 1380 Query 1381 EGEIPRSKLAKVLEYAEEGPEKEFLKSLVEAGVTWVKVKEVEEEHYTGKLYDFTTTTENF 1440 EGEIPR KL+KVLEYAEE PEKEFLKSLVEAGVTWVKVK VEEE YTGKLYDFTTTTENF Sbjct 1381 EGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENF 1440 Query 1441 LSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRP 1500 LSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQE+GE+YFKPR WGEEG HEAIRPTRP Sbjct 1441 LSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRP 1500 Query 1501 IDTGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKA 1560 IDTGRLMQL+RDGIIQLP+NLTRNHYRLYDMIFRRFMTSQM AK+L E+AVI+AGVGKA Sbjct 1501 IDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKA 1560 Query 1561 ELEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKE 1620 ELEGYVEIIEDGWT+LRSP R+LP+L++G KLKVVEAKKWKAPKV LY+QGDIIA+MKE Sbjct 1561 ELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKE 1620 Query 1621 RKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSL 1680 RKIGRPSTYAKIV+TL++R YV ET+GRKKL+PT+KGIKVYHYLV+KY+DLVSEE+TR L Sbjct 1621 RKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTREL 1680 Query 1681 EEKMDLIEEGKLDYLKVLYDLYNEILCGVKG 1711 EE MD IEEG DY+KVL +LY+EI V G Sbjct 1681 EEIMDRIEEGIEDYIKVLGELYSEIQRYVSG 1711 >RecName: Full=Reverse gyrase; Contains: RecName: Full=Pho r-Gyr intein [Pyrococcus horikoshii OT3] Sequence ID: O58530.1 Length: 1624 Range 1: 1 to 1619 Score:2363 bits(6123), Expect:0.0, Method:Compositional matrix adjust., Identities:1189/1706(70%), Positives:1409/1706(82%), Gaps:88/1706(5%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 MKAIYR MCPNC G I+DERL NKNPC+ CL EP+ ++ Y ELI AVRNALK++GTLK+W Sbjct 1 MKAIYRGMCPNCRGAITDERLSNKNPCEGCLSEPILSEDYNELIVAVRNALKLRGTLKDW 60 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 E +Y L K + EIE FE++TGF FWSAQRTWVKR+++G+SFSIIAPTGMGKSTFGAF++ Sbjct 61 EELYRLNKEVSEIEELFEKSTGFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFIS 120 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQ 180 ++ ATKGKKSYIVVPTTPLVIQTV+KI+++ E+A + + L YYHGNLRKKEKEE L KI+ Sbjct 121 IYFATKGKKSYIVVPTTPLVIQTVKKIESMLEKANVSVRLVYYHGNLRKKEKEEALEKIR 180 Query 181 GEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIG 240 D+DIL+TS+Q++A +F E+LK + FD IFVDDVDAFLKASKNIDRSL +LGF+++IIG Sbjct 181 NGDFDILITSSQFLATRFKELLKDKKFDLIFVDDVDAFLKASKNIDRSLIMLGFSEEIIG 240 Query 241 KAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATG 300 +AWE+IKLKKQ++K L + EE++++LN EI +++ EIEE+KR NKIGI+I+ASATG Sbjct 241 RAWEVIKLKKQLAKLLQ-NEKKNEEEIEKLNKEIEKIEDEIEEYKRRNKIGILIVASATG 299 Query 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPI 360 SA+GDRIKLYRELLGFEVGSGRS LRN+VD+YL P + I+ HV ELL LGKGG+IF PI Sbjct 300 SAKGDRIKLYRELLGFEVGSGRSVLRNIVDTYLLPEKPIEEHVVELLRKLGKGGLIFVPI 359 Query 361 DQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLP 420 D+G+ YAEEL +YL+ +GF+VELVS+KNKK +E FE GE DYLVG ATYYG+LVRGLDLP Sbjct 360 DKGIEYAEELTDYLKSQGFKVELVSAKNKKGLELFEKGEIDYLVGVATYYGTLVRGLDLP 419 Query 421 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRN 480 HLIR+A+FTGVPKFRFS+DLE+PTIYR LGL+SEI++FL +E + + EKL+ARLRRLIRN Sbjct 420 HLIRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEEKKSEGEKLYARLRRLIRN 479 Query 481 IPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLT 540 IPQ+EL+KIEEALAEGL +E FHNHVL VF++ VEFLR+ L DEEV+KK+AE+PF+SL Sbjct 480 IPQYELMKIEEALAEGLELEG-FHNHVLEVFKQSVEFLREVLKDEEVIKKIAENPFLSLK 538 Query 541 EEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEF 600 E EGK YIEIPDVRTYIQA+GRTSRLFAGGITKGLSV+IVD++KVFNGL+RQMRWRF EF Sbjct 539 EIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEF 598 Query 601 KMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFF 660 + FEE++L E+LK+ID DREKV+LV+EGKIS +VKDLVKSALMIVESPNKARTIA+FF Sbjct 599 DIKKFEEVNLKEVLKEIDRDREKVKLVIEGKISEQVKDLVKSALMIVESPNKARTIASFF 658 Query 661 GQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYD 720 GQPSK +IGDL AYEVSIG+ MLTILASGGHMFDLVTNEGYHGV+I + F+PVYD Sbjct 659 GQPSKRKIGDLTAYEVSIGDKMLTILASGGHMFDLVTNEGYHGVLILKNNGKPYFVPVYD 718 Query 721 TIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGE 780 TIKRCRDCGHQFVDWEQKGVCPRCGS NV DAL+NVKAMRELA EVDEILI TDPDTEGE Sbjct 719 TIKRCRDCGHQFVDWEQKGVCPRCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGE 778 Query 781 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGF 840 KIAWDIRNVL+PY PNIKRIEFHEVTRPAI++AI+EARD+NE RVNAQ+VRRIEDRWIGF Sbjct 779 KIAWDIRNVLAPYAPNIKRIEFHEVTRPAILRAIREARDINEDRVNAQLVRRIEDRWIGF 838 Query 841 ELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQFTVEIGK- 899 ELSQ+L VFENRNLSAGRVQTPVLGWI++RYKEF+ESET FLG+ LENG+ T+E K Sbjct 839 ELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGIILENGINVTIENAKG 898 Query 900 DGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 + +EVE V+ V +EEK+ NP PPYTTD ML+DAS FL SA +TM+LAQDLFEAG Sbjct 899 EVREVE------VKDVIIEEKDVNPLPPYTTDTMLQDASRFLGFSATKTMQLAQDLFEAG 952 Query 960 LCVTPDTLVSLSDGRIMEIKEAVEGSEGNLLAVNGLKPKEAKALKFWEIDWNGPLKVIKL 1019 LCVTPDTLVSLSDGRI+EI+EAVE SE +LL +NGLKPKEAKALKFWEIDW+GP+KVIKL Sbjct 953 LCVTPDTLVSLSDGRIIEIREAVENSEESLLGINGLKPKEAKALKFWEIDWDGPIKVIKL 1012 Query 1020 KNGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVAFAYNTGHRGREEYTLLNLLIKLG 1079 KNGHEIKATPDHGLLVMRDGK+GWVSAKNIREGDYVAF YN GHRG ++YTL LL +LG Sbjct 1013 KNGHEIKATPDHGLLVMRDGKIGWVSAKNIREGDYVAFIYNLGHRGGKKYTLPQLLKELG 1072 Query 1080 ITDVMVEVDEEYFNEKVAPIIKERIPTSTKYKYLRRYVLPLHLLQEWRIDDYETHVKSLY 1139 I++ +E N + Sbjct 1073 ISEYENSSSQELNNRE-------------------------------------------- 1088 Query 1140 RQRAGSKPIPNFKLDERFWYVFGLVLGDGTLRNSKVLISQTPLKDVKSVLKEVFPFLYVF 1199 Q SK I + +LDERFWY+FG++LG GTL+ KV+I Q KDVK V++E PF+ +F Sbjct 1089 -QEMDSKQI-SIELDERFWYIFGVILGKGTLKGDKVVIFQ---KDVKPVIEEALPFVRIF 1143 Query 1200 ETTTQVGFSNSILAEVFRRLGAREGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNGRK 1259 E+ +GFS+ ILAEVFRRLG EGKLH LVFGLREEYINAMIAGYFD GTF Sbjct 1144 ESADHIGFSHLILAEVFRRLGVGEGKLHSLVFGLREEYINAMIAGYFDASGTFL------ 1197 Query 1260 GPNFRAILTSKRGDVLRMLSVYLYQVGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPY 1319 RA+LTSKRGD+LRMLSVYLYQ+GI+N LRRDE GVW+LIIS+ LEKFREKIYPY Sbjct 1198 ---RRAVLTSKRGDILRMLSVYLYQIGIVNNLRRDEHAGVWELIISD--LEKFREKIYPY 1252 Query 1320 LRIRRRQFEEAYSVYRSSRRAFEEDLLPVASIFRKLKFRNGVKNRILKETGIDIWNWLKR 1379 LRI++ QF++ YS+ ++ E D LPVASIFRKLKFR+G KNRIL E Sbjct 1253 LRIKKSQFDKVYSISKN-----EGDFLPVASIFRKLKFRDGFKNRILDE----------- 1296 Query 1380 LEGEIPRSKLAKVLEYAEEGPEKEFLKSLVEAGVTWVKVKEVEEEHYTGKLYDFTTTTEN 1439 EIPR ++AKVLEYAE+ PEKEFL SLVEA VTWV+V+++EE HYTGKLYDFTTTTEN Sbjct 1297 ---EIPRDEVAKVLEYAEDSPEKEFLNSLVEARVTWVRVEKIEERHYTGKLYDFTTTTEN 1353 Query 1440 FLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTR 1499 F+SNG VSHNCTYHRTDS HVSNTGIEVAKEYITQE+GEEYF PR WGEEG HEAIRPTR Sbjct 1354 FISNGIVSHNCTYHRTDSIHVSNTGIEVAKEYITQEIGEEYFTPRKWGEEGAHEAIRPTR 1413 Query 1500 PIDTGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGK 1559 PIDTGRL+QL+RDGII +PKNLTR+H+RLYD+IFRRFM SQMK AK+L E+A+I Sbjct 1414 PIDTGRLIQLIRDGIITIPKNLTRDHFRLYDLIFRRFMASQMKPAKILYEKAIISTPFKD 1473 Query 1560 AELEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMK 1619 E+EGY++++ DGW+K++S RQ+P+L++G +L+V E K+W+APKV LY+QGD+IA+MK Sbjct 1474 VEVEGYIDVLYDGWSKIKSLPLRQIPKLEKGQRLRVKEVKQWRAPKVSLYTQGDVIALMK 1533 Query 1620 ERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRS 1679 ER IGRPSTYAKIVQTLLQR YV ET+G+KKLVPT+KGIKVY YL+TKYKDLVSEE+TR Sbjct 1534 ERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLITKYKDLVSEERTRQ 1593 Query 1680 LEEKMDLIEEGKLDYLKVLYDLYNEI 1705 LE+ MD++EE K DY VL +LY EI Sbjct 1594 LEKIMDMVEEAKADYQDVLNELYEEI 1619 >RecName: Full=Reverse gyrase [Pyrococcus furiosus DSM 3638] Sequence ID: P95479.2 Length: 1214 Range 1: 1 to 953 Score:1439 bits(3724), Expect:0.0, Method:Compositional matrix adjust., Identities:703/961(73%), Positives:839/961(87%), Gaps:8/961(0%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 MKAIYR+MCPNC G I+DERL KNPCD CLDEP+ D YF+L+TA+R ALK+KG LKEW Sbjct 1 MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEW 60 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 E IY+L K ++EIE F++ATGFTFWSAQR+WVKR++KG+SFSIIAPTGMGKSTFGAFM+ Sbjct 61 EEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMS 120 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQ 180 ++ A KGKKSYIVVPTTPLV+QTV+KI+A+ E+A +++NL YYHGNL+KKEK+E L KI+ Sbjct 121 IYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIK 180 Query 181 GEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIG 240 ++DILVTS+Q++A +FDE+LK + DF+FVDDVDAFLKASKNIDRSL +LGFN++II Sbjct 181 SGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIK 240 Query 241 KAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATG 300 KAWEIIKLKKQ++K L + + E++++LN EI RL+REIE +K+ENKIGI+I+ASATG Sbjct 241 KAWEIIKLKKQLAKLLQNESGN--EEVEKLNREIERLEREIERYKKENKIGILIVASATG 298 Query 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPI 360 SARGDRIKLYRELLGFEVGSGRS LRN+VD+Y+ P + ++ HVEELL LG+GG+IF PI Sbjct 299 SARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPI 358 Query 361 DQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLP 420 D+G+ YAE+L NYL+ +GF+VELVS+++KK +E FE E DYLVG ATYYG++VRGLDLP Sbjct 359 DKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLP 418 Query 421 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRN 480 HL+R+A+FTGVPKFRFS+DLE+PTIYR LGL+SEI++FL +E R + EKL+ARLRRLIRN Sbjct 419 HLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRN 478 Query 481 IPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLT 540 IPQ+EL+KIEEALAEGL +E F+NHVL VF++ VEFLR+AL DEEVLKK+AE+PF+SL Sbjct 479 IPQYELMKIEEALAEGLELEG-FYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLK 537 Query 541 EEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEF 600 + EGKWYIEIPDVRTYIQA+GRTSRLFAGGITKGLSV++VD++KVFNGL+RQMRWRF EF Sbjct 538 QIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEF 597 Query 601 KMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFF 660 ++ P E++++E+LK+ID DREKVRLV+EGKIS +VKDLVKSALMIVESPNKARTIANFF Sbjct 598 EIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFF 657 Query 661 GQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYD 720 GQPSK RIGDLVAYEVSIG+ MLTILASGGHMFDLVT EGYHGV++ G F+PVYD Sbjct 658 GQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYD 717 Query 721 TIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGE 780 TIKRCRDCGHQFVDWE+KGVCPRCGS NV DAL+NVKAMR+LAQEVDEILI TDPDTEGE Sbjct 718 TIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGE 777 Query 781 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGF 840 KIAWDIRNVLSPY P IKRIEFHEVTRPAI++AI EARD+NE RVNAQ+VRRIEDRWIGF Sbjct 778 KIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGF 837 Query 841 ELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQFTVEIGKD 900 ELSQ+L VFEN NLSAGRVQTPVLGWI++RYKEF+ESET FLGLTLEN + +E G Sbjct 838 ELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILE-GVS 896 Query 901 GKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL 960 G E V V++V +EE+E NP PPYTTDAML+DAS FL SA TM+LAQDLFE GL Sbjct 897 GDVQE----VYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGL 952 Query 961 C 961 Sbjct 953 T 953 Range 2: 953 to 1214 Score:392 bits(1006), Expect:8e-113, Method:Compositional matrix adjust., Identities:183/262(70%), Positives:223/262(85%), Gaps:0/262(0%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQL 1509 TYHRTDS HVSNTGIE+AKEYITQE+GEEYF PR WGEEG HEAIRPTRPIDTGRL+QL Sbjct 953 TTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQL 1012 Query 1510 VRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEII 1569 +RDGII LP+NLT++H++LYD+IFRRFM SQMK AK+L ERAVI G+ E+EGY+++I Sbjct 1013 IRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVI 1072 Query 1570 EDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTY 1629 DGW++++ ++LPRL++ LKV E +KW+APKV LY+QGD+IA+MKER IGRPSTY Sbjct 1073 YDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTY 1132 Query 1630 AKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEE 1689 AKIVQTLLQR YV ET+ +KKLVPT+KGIKVYHYLV+KYKDLVSEE+TR LE+ MD++EE Sbjct 1133 AKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEE 1192 Query 1690 GKLDYLKVLYDLYNEILCGVKG 1711 K +Y +VL +LY EIL VK Sbjct 1193 AKANYQEVLNELYEEILRYVKS 1214 >RecName: Full=Reverse gyrase [Pyrococcus abyssi GE5] Sequence ID: Q9UZ86.1 Length: 1214 Range 1: 1 to 953 Score:1397 bits(3616), Expect:0.0, Method:Compositional matrix adjust., Identities:696/961(72%), Positives:832/961(86%), Gaps:8/961(0%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 MKAIYR MCPNC G I+DERL KNPC+ CL EP+ A+ Y +L+ AVRNALK++GTLK+W Sbjct 1 MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDW 60 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 E +Y L K + E+E F+RATGF FWSAQRTWVKR+L+G+SFSIIAPTGMGKSTFGAF++ Sbjct 61 EDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFIS 120 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQ 180 ++ A KGK+SYIVVPTTPLV+QTV+KIQ + ERAG+ + L YYHGNL+KKEKEE L +I+ Sbjct 121 IYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIK 180 Query 181 GEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIG 240 D+DILVTS+Q++A +FDE+L+ + FD IFVDDVDAFLKASKNIDRSL LLGF ++I Sbjct 181 DGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVIN 240 Query 241 KAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATG 300 +AWE+IKLKKQ++K L + +++E ++ELN EI +++REIE ++REN IGI+I+ASATG Sbjct 241 RAWEVIKLKKQLAKLLQAQGKEKE--VEELNKEIEKIEREIERYRRENNIGILIVASATG 298 Query 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPI 360 SARGDRIKLYRELLGFEVGSGRS LRN+VD+Y+ P R I+ VE LL LGKGG+IF PI Sbjct 299 SARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPI 358 Query 361 DQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLP 420 D+G+ +AEEL NYL+ +GF+VELVS+KNK+ +E FE GE DYLVG ATYYG++VRGLDLP Sbjct 359 DKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLP 418 Query 421 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRN 480 HLIR+AVF GVPKFRFS+DLE+PTIYR LGL+SEI++FL E R++ EKL+ARLRRLIRN Sbjct 419 HLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRN 478 Query 481 IPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLT 540 IPQ+EL+KIEEALAEG+ +E FHNHVL VF++ VEFLR+ L DEEV+++++E+PF+SL Sbjct 479 IPQYELMKIEEALAEGIELEG-FHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLK 537 Query 541 EEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEF 600 E EGK YIEIPDVRTYIQA+GRTSRLFAGGITKGLSV+IVD++KVFNGL+RQMRWRF EF Sbjct 538 EVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEF 597 Query 601 KMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFF 660 ++ FEE++L+ +L++IDEDR+KVRLV+EGKIS +VKDLVKSALMIVESPNKARTIA+FF Sbjct 598 EIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFF 657 Query 661 GQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYD 720 GQPSK RIG+LVAYEVSIG+ MLTILASGGHMFDLVT EGYHGV+I D ++PVYD Sbjct 658 GQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYD 717 Query 721 TIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGE 780 TIKRCRDCGHQFVDWEQKGVCP+CGS NV DAL+NVKAMRELA EVDEILI TDPDTEGE Sbjct 718 TIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGE 777 Query 781 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGF 840 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAI+KAI+EARD+NE RV AQ+VRRIEDRWIGF Sbjct 778 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGF 837 Query 841 ELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQFTVEIGKD 900 ELSQ+L VFENRNLSAGRVQTPVLGWI++RYKEF+ESET FLGLTLENG+ T+E K Sbjct 838 ELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKG 897 Query 901 GKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL 960 + V V+ V +EE+E NP PPYTTDAML+DAS FL SA +TM+LAQDLFE GL Sbjct 898 EVKE-----VEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGL 952 Query 961 C 961 C Sbjct 953 C 953 Range 2: 953 to 1208 Score:391 bits(1005), Expect:1e-112, Method:Compositional matrix adjust., Identities:180/256(70%), Positives:221/256(86%), Gaps:0/256(0%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQL 1509 CTYHRTDS HVSNTGIE+AKEYI++E+GEEYF PR WGEEG HEAIRPTRPIDTGRL+QL Sbjct 953 CTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQL 1012 Query 1510 VRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEII 1569 +RDGII LP+NLT++H+RLYD+IFRRF+ SQMK A++L E+A+I G E+EGY+EI+ Sbjct 1013 IRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEIL 1072 Query 1570 EDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTY 1629 DGW++++ +Q+P+L++G KLKV E K+W+APKV LY+QGD+IA+MKER IGRPSTY Sbjct 1073 YDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTY 1132 Query 1630 AKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEE 1689 AKIVQTLLQR YV ET+GRKKLVPT+KGIKVY YLV+KYKDLVSEE+TR LE+ MD IEE Sbjct 1133 AKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEE 1192 Query 1690 GKLDYLKVLYDLYNEI 1705 K DY +VL +L+ EI Sbjct 1193 AKADYQEVLRELHEEI 1208 >RecName: Full=Reverse gyrase; Contains: RecName: Full=Mja r-Gyr intein [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q58907.1 Length: 1613 Range 1: 5 to 1610 Score:1330 bits(3443), Expect:0.0, Method:Compositional matrix adjust., Identities:779/1723(45%), Positives:1090/1723(63%), Gaps:137/1723(7%) Query 4 IYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWERI 63 IY+EMCPNC G I+ ERL C++CL E ++ FE + L+ + TLK + Sbjct 5 IYKEMCPNCNGEITSERLA-IGVCEKCLKE----ENVFEKLKLCE-KLREEKTLKNLKDY 58 Query 64 YSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWH 123 + +E E F + GF S Q+ W KR+LK +SFSI+ PTG+GKS FG M+++ Sbjct 59 CIIWNEFKEFEEFV-KDLGFELLSIQKMWAKRVLKNKSFSIVVPTGVGKSFFGILMSLFL 117 Query 124 ATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQGED 183 A KGK+ YI++PTT LV QT KI ++ E+ + I + YH L KEK+E+ +I+ D Sbjct 118 AKKGKRCYIILPTTLLVKQTYEKISSLTEKNNLNIRVVAYHSELSTKEKKEVKERIENND 177 Query 184 YDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIGKAW 243 YD+L+T++ ++ + + FDF+FVDDVDA LKASKNIDR+L LLGF+++II +A+ Sbjct 178 YDVLITTSNYLTKNMPKC----KFDFVFVDDVDALLKASKNIDRTLKLLGFDEEIINEAY 233 Query 244 EIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATGSAR 303 +II L K G+ +D +K + L +IS+++ G +IIASATG + Sbjct 234 KIIYLIKI------GKIEDAMKKREILKKKISKIKH-----------GCLIIASATGKSY 276 Query 304 GDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPIDQG 363 GDR+KLYRELL FE+G G + LR+VVD Y + K + E + + G GGI+F ID G Sbjct 277 GDRVKLYRELLDFEIGFGMNKLRDVVDIYDEEFS--KEKILEYIKLFGSGGIVFVSIDYG 334 Query 364 LGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLPHLI 423 + A+E+ YL E + +L+ SK+KK + F G+ D L+G A+YYG LVRGLD+P + Sbjct 335 VEKAQEIEKYLLENNIKAKLIHSKDKKGFDDFREGKIDVLIGVASYYGVLVRGLDMPERV 394 Query 424 RYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRNIPQ 483 RYA+F G+PKF+ RL+ I + Sbjct 395 RYAIFYGIPKFKI------------------------------------RLKEYINS--- 415 Query 484 FELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLTEEE 543 LK + L E + IE + + + E KL F SL +E+ Sbjct 416 ---LKEKGELKEDINIEGKTEEEIRQIITE----------------KLKIKNF-SLRKED 455 Query 544 GKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQ-EFKM 602 ++ + IPDV+TYIQA+GRTSR+ G+TKG S+++VD +++F L + M + ++ EFK Sbjct 456 DEYLLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMYESEFKR 515 Query 603 VPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQ 662 + +E++L+E++K+IDEDREK+++ G+ KV DL+KS LM+VESPNKARTIANFFG+ Sbjct 516 I--DEVNLEELIKKIDEDREKIKV---GRAKGKVPDLLKSVLMVVESPNKARTIANFFGK 570 Query 663 PSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYDTI 722 PS +I + YEV IG++ L I ASGGH+FDLVT EG++GV I+N+ +IP+Y +I Sbjct 571 PSVRKINNRNVYEVCIGDLNLIITASGGHVFDLVTKEGFYGVKIENN----LYIPIYTSI 626 Query 723 KRCRDCGHQFVDWEQ-----KGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDT 777 K+ G QF D + K + + N DA +N++ +RE+A EVD I IATD DT Sbjct 627 KKVN--GEQFTDQKDLEELIKQLMEKGERVNAMDAKENIEIIREIADEVDAIFIATDIDT 684 Query 778 EGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQ-----EARDVNEGRVNAQIVRR 832 EGEKI +DI P+ NI R+ F+E+T+ AI+KA++ E ++E +V Q+VRR Sbjct 685 EGEKIGYDIAINALPFNRNIYRVGFNEITKRAILKAVESFKKGEELSLDENKVKGQVVRR 744 Query 833 IEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQ 892 IEDRWIGF LSQ+L VF LSAGRVQTPVLGWIIERY E + + +L L LEN + Sbjct 745 IEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNE-HKIKVPYLSLKLENDIY 803 Query 893 FTVEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLA 952 IGK ++ E + +V++ EKE P PP+TTD +L++A+ LS E M +A Sbjct 804 ----IGKIWED-EFDKDEVEVEVKVYEKEIPPLPPFTTDTLLEEATKRFGLSTDEIMSIA 858 Query 953 QDLFEAGLCVTPDTLVSLSDGRIMEIKEAVEGSEGNLLAVN--GLKPKEAKALKFWEIDW 1010 Q+LFE GLC+TPDT V L DGRI I++ V E N+L+++ L K A+KFW++ + Sbjct 859 QELFELGLCLTPDTYVVLGDGRIETIEDIVNAKERNVLSLDLDNLSIKIDTAIKFWKLRY 918 Query 1011 NGPLKVIKLKNGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVAFAYNTGHRGREEYT 1070 NG L I L N +E+KATPDH LLV+RD +L W+ AK+I+E DY+A +N R+ + Sbjct 919 NGNLSKITLSNNYELKATPDHCLLVLRDNQLKWIPAKDIKENDYIAMPFNYKVE-RKPIS 977 Query 1071 LLNLLIKLGITDVMVEVDE-EYFNEKVAPIIKERIPTSTKYKYLRRYVLPLHLLQEWR-- 1127 LLNLL L ITDV++E DE EK+A I+ I TSTKYKYLR +PL L EW Sbjct 978 LLNLLKYLDITDVLIEFDENSTIFEKIAEYIRNNIKTSTKYKYLRNRRVPLKYLIEWNFD 1037 Query 1128 IDDYETHVKSLYRQRAGSKPIPNFKLDERFWYVFGLVLGDGTLRNSKVLISQTPLKDVKS 1187 +D+ E K +Y+ AG+K IP FKLDERFWY GLVLGDG++++SK+ I+QTPLKDVKS Sbjct 1038 LDEIEKEAKYIYKSVAGTKKIPLFKLDERFWYFAGLVLGDGSIQDSKIRIAQTPLKDVKS 1097 Query 1188 VLKEVFPFLYVFETTTQVGFSNSILAEVFRRLGAREGKLHPLVFGLREEYINAMIAGYFD 1247 +L E FPFL+ + + QV SN I+AE+ +LG R GKL+ ++F L E YINA+IAGYFD Sbjct 1098 ILDETFPFLHNWISGNQVIISNPIIAEILEKLGMRNGKLNGIIFSLPESYINALIAGYFD 1157 Query 1248 TDGTFSILNGRKGP--NFRAILTSKRGDVLRMLSVYLYQVGIMNYLRRDERTGVWDLIIS 1305 TDG FS+L +K N R +LTSKR DVL + +YL +GI+N L + V+ LIIS Sbjct 1158 TDGCFSLLYDKKAKKHNLRMVLTSKRRDVLEKIGIYLNSIGILNTLHKSRE--VYSLIIS 1215 Query 1306 NRSLEKFREKIYPYLRIRRRQFEEAYSVYRSSRRA-FEEDLLPVASIFRKLKFRNGVKNR 1364 N+SLE F+EKI YL+IR+ F Y Y+ FE DLLPV +F+KL F G K Sbjct 1216 NKSLETFKEKIAKYLKIRKEAFINGYKTYKKEHEERFECDLLPVKEVFKKLTFEKGRK-E 1274 Query 1365 ILKETGIDIWNWLKRLEGEIPRSKLAKVLEYAEEGPEKEFLKSLVEAGVTWVKVKEVEEE 1424 ILK++ I I NW K IPR KL VL YA KEFL+ +V +++V+VK+VE Sbjct 1275 ILKDSKIHIENWYKEKTNNIPREKLKTVLRYANNSEHKEFLEKIVNGDISFVRVKKVENI 1334 Query 1425 HYTGKLYDFTTT-TENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKP 1483 Y G +YD + +NF+SNG +SHNCTYHRT ST VS G+ VA+EY+ E+Y K Sbjct 1335 PYDGYVYDLSIKHNQNFISNGVISHNCTYHRTSSTRVSLDGMRVAREYLKLNNLEDYLKN 1394 Query 1484 RHWGEEGTHEAIRPTRPIDTGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKA 1543 R + EG HE IRPT+P++T L++ +++ I+ LT+NH ++YD+IFRRF+ SQMK Sbjct 1395 REYFMEGAHECIRPTKPMNTDELIEFLKENNIK----LTKNHIKVYDLIFRRFIASQMKE 1450 Query 1544 AKLLMERAVIDAGVGKAELEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKA 1603 A + E I K +EGYV+I DGW+++ + ++LPR+ E + LKV++ K K Sbjct 1451 AVVEYEEIYIKDLDEK--VEGYVDIKFDGWSRIYNLKLKKLPRI-EKSSLKVLDKKLRKI 1507 Query 1604 PKVQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHY 1663 PKV LY +G+++ +MKER IGRPSTYA+I++ LL R YV +++ + KL+PT GI+VY+Y Sbjct 1508 PKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVVKSKDKNKLIPTKLGIEVYNY 1567 Query 1664 LVTKYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEIL 1706 L+ Y L+SEE+TR LEE MD IE G++DY++VL L+ EIL Sbjct 1568 LINNYPHLISEERTRELEEIMDKIENGEVDYIEVLKALHEEIL 1610 >RecName: Full=Reverse gyrase 1 [Aeropyrum pernix K1] Sequence ID: Q9YCB6.2 Length: 1370 Range 1: 9 to 1055 Score:715 bits(1846), Expect:0.0, Method:Compositional matrix adjust., Identities:446/1071(42%), Positives:627/1071(58%), Gaps:107/1071(9%) Query 2 KAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWE 61 + +YR +CPNC G S+ERL PC CL P T + L+ +GTL Sbjct 9 RGVYRYLCPNCGGPNSEERLSRGLPCPRCL--PRLPRKGVSGWTGLARLLRREGTLGAGV 66 Query 62 R-IYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 + + SLE+ R + FFE+A G W AQRTW KRL +G SFSIIAPTG+GK+TFGA + Sbjct 67 KAMASLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAAS 126 Query 121 VWHATK-GKKSYIVVPTTPLVIQTVRKIQAVAERAGI-EINLAYYHGNLRKKEKEEMLAK 178 +++A K G +SYIV+PTT L RK++++ E G + L H L+ E+ E + + Sbjct 127 LFYACKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAMER 186 Query 179 IQGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDI 238 + D+DILVT+A + ARK+ + L G F +FVDDVDA L++++++D L ++GF+++ Sbjct 187 FEKGDFDILVTTAAF-ARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEEA 245 Query 239 IGKAWEIIKLKKQMSKYLNGRAQDREE-------KLKELNSEISRLQREIEEFKRENKIG 291 I K E+++L+++ ++ + REE KL E+ + RL+ EIE R + Sbjct 246 IEKGLEVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIE--ARRGRTA 303 Query 292 IMIIASATGSARGDRIKLYRELLGFEVGS-GRSALRNVVDSYLKPTRDIKGHVEELLTML 350 +I++SATG RG R++L+R LL FE G G LR V+DSY PT + V EL+ L Sbjct 304 SLIVSSATGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRRL 363 Query 351 GKGGIIFTPIDQGLGYAEELVNYLRERGFRVELVSSKNK-KAIERFENGEADYLVGSATY 409 G GG+++ PID G+ YAE L LR G + E +K + ++RF GE D LVG A Y Sbjct 364 GTGGLVYVPIDMGVEYAERLAEELRRAGVKAEAYHAKKPLELLDRFAEGEIDVLVGVANY 423 Query 410 YGSLVRGLDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEK 469 YG+LVRGLDLP +RYAVF GVP+ +F D+ P R L LLS + + +E A Sbjct 424 YGTLVRGLDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASAARS 483 Query 470 LHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLK 529 RLRR++R + L I E +A G +E + VL E +FLR+AL ++V + Sbjct 484 HMGRLRRMLRVLSPAALQMIAERVARG-EVEGGYDRQVL----EAYQFLREALARDDVWE 538 Query 530 KLAEDPFVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGL 589 L E V + E G+ YI +PD TY+QA+GRTSRL+AGGIT GLSV++VDNE V GL Sbjct 539 SLRELD-VGIVREGGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMRGL 597 Query 590 VRQMRWRFQEFKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVES 649 ++++ W E FE+LDL IL++IDEDREKVR V++G +LV++AL++VES Sbjct 598 MKRVSW-MAEVDWRRFEDLDLQSILREIDEDREKVRRVVKGLYRGV--ELVRTALLVVES 654 Query 650 PNKARTIANFFGQPS-KTRIGDLVAYEVSIGNMMLTILASGGHMFDLVT----------- 697 PNKARTIA FFGQPS + G YEV+ G+ +L I+ASGGH+FDLV Sbjct 655 PNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEAAG 714 Query 698 NEGYHGVI----IQNDGN-MLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDA 752 E H + + GN + PVY +IKRC DCG+QFVD + CPRCGS +R++ Sbjct 715 GEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVD--EASRCPRCGSELIRNS 772 Query 753 LDNVKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMK 812 L V+ +R +A E DE+ + TDPDTEGEKI WD+ L PY P+IKR+EFHEVT+ AI++ Sbjct 773 LSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAILE 832 Query 813 AIQEARDVNEGRVNAQIVRRIEDRWIGFELSQEL---------QRVFEN----------- 852 A+ R ++ V+AQ+VRR+EDRWIGF LS L +RV E Sbjct 833 ALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMDRE 892 Query 853 --------RNLSAGRVQTPVLGWIIER----------YKEFSESETYF------------ 882 NLSAGRVQTP LGW+++R Y+ +S+ F Sbjct 893 RCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVPES 952 Query 883 LGLTLENGLQFTVEIGKDGKEVEPPEYVTVEKVELEEKEFNP---QPPYTTDAMLKDAST 939 + L+N ++ + G +EP ++ V+ V +E++E+ PPYTTD ML+DA+ Sbjct 953 VKRVLDNWVKHHKKTG-----IEP--WLDVKAV-VEKEEWTALPPPPPYTTDTMLRDANR 1004 Query 940 FLKLSAPETMRLAQDLFEAGLCVTPDTLVSLSDGRIMEI-KEAVEGSEGNL 989 L L + E MR+AQDLFE GL T + R M++ +E +E G L Sbjct 1005 LLGLGSAEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGL 1055 Range 2: 972 to 1319 Score:206 bits(524), Expect:3e-52, Method:Compositional matrix adjust., Identities:142/354(40%), Positives:188/354(53%), Gaps:69/354(19%) Query 1415 WVKVKEV-EEEHYTGKLYDFTTTTENFLSN-----GAVSHNC-------------TYHRT 1455 W+ VK V E+E +T TT+ L + G S TYHRT Sbjct 972 WLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGSAEAMRIAQDLFEWGLITYHRT 1031 Query 1456 DSTHVSNTGIEVAKEYITQEVGE---EYFKPRHWGEEGTHEAIRPTRPIDTGRLMQLVRD 1512 DST VS+ G++VA+E++ G + ++PR WGE G HEAIRP RPID RL LV + Sbjct 1032 DSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGAHEAIRPVRPIDVERLQLLVEE 1091 Query 1513 GIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEIIE-- 1570 G+I+LP LTR H RLYD+IFRRFM SQM+ A L R V V EL+GY +E Sbjct 1092 GVIELPGTLTRRHLRLYDLIFRRFMASQMREADAL--RVVYRLRV--PELDGYTLTLERV 1147 Query 1571 ---------DGWTK---LRSPNFRQLPRLKEGAKLKV---VEAKKWKAPKVQLYSQGDII 1615 +G T+ L P R PRL EG + + VE + + PK Y++G+I+ Sbjct 1148 VEIGRPGDAEGVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGR--QVPKAYPYTEGEIV 1205 Query 1616 AMMKERKIGRPSTYAKIVQTLLQRYYVFET-----RGRKKLVPTDKGIKVYHYLVTKYK- 1669 MK R IGRPSTYAKIV+TL +R YV E RG +V T +GI VY+YL + + Sbjct 1206 EEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGINVYNYLTEELRS 1265 Query 1670 ------------------DLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEI 1705 LVSE++TR LE +MD++E+G VL ++NEI Sbjct 1266 ADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLESVFNEI 1319 >RecName: Full=Reverse gyrase [Pyrobaculum aerophilum str. IM2] Sequence ID: Q8ZXT5.1 Length: 1228 Range 1: 8 to 965 Score:701 bits(1810), Expect:0.0, Method:Compositional matrix adjust., Identities:411/990(42%), Positives:599/990(60%), Gaps:65/990(6%) Query 5 YREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWERIY 64 Y CPNC G I+ +RL + PC ECL + A S ++ITA+R ++G W Y Sbjct 8 YLHSCPNCGGPITSDRLASGLPCRECLPDGAKAGSIKQVITALRKRKALQGL--AWVEAY 65 Query 65 SLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHA 124 + E FF+R GF W AQR W +R ++G+SF+I+APTG GK+TF ++ A Sbjct 66 L--RGYEEFAEFFKRIVGFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATLYSA 123 Query 125 TKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQGEDY 184 +GK++ ++ PT+ L Q +K+ AER G+ + YH L ++EK+E L ++ D+ Sbjct 124 KQGKRALLIFPTSALAHQAYKKLLTFAERGGVSLKALAYHSLLTEREKKEALEALERGDF 183 Query 185 DILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKA-SKNIDRSLYLLGFNDDIIGKAW 243 D+LVT++ ++ ++F E+L FDF+ DDVD+ L+A SKNIDR L LLG +D ++ A Sbjct 184 DVLVTTSAFLPKRF-ELLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDAVLNTAL 242 Query 244 EIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATGSAR 303 E+I L KQ+ K A D +E ++ L+ E+++L+ ++ E + K+G+ + + A AR Sbjct 243 EVINLTKQLRK--AEVAGDLKE-VERLDQEMAKLRAKLREEVQRLKLGVFVASGALAKAR 299 Query 304 GD-RIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPIDQ 362 R+ L+RE+LGF+VG LRNVVD Y++ + ++ L+ LG GGII+ D+ Sbjct 300 RTVRLLLFREILGFDVGGRAEGLRNVVDLYVEASDNVIEQTLALVKRLGPGGIIYVQ-DR 358 Query 363 GLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLPHL 422 LG E +V RE G VE + +E FE GE LVG A+ +LVRG+DLPH+ Sbjct 359 ELG--EAIVERAREAGLAVEHFFRPRRGVLESFERGELAALVGLASSRSALVRGIDLPHV 416 Query 423 IRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRNIP 482 IRY +F GVPKF+F + LE +I L L + L+ + R +A++L +L+RL Sbjct 417 IRYVIFVGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLAGDARYKADRLIGQLKRLAPYA- 475 Query 483 QFELLKIEEAL---AEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSL 539 L ++EAL +EG + + F H + V + VEF+ L +EE+ K + V L Sbjct 476 ----LSVQEALKKASEGAELSS-FDRHAVDVVKSAVEFVNSLLQNEEIRKAIETSSEVKL 530 Query 540 TEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQE 599 +G+ Y+ +PDV TYIQ +GRTSRL+AGG++KGLSV+IVD+ KVF+ L R++ RF E Sbjct 531 AYIDGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDPKVFHALKRELSLRFDE 590 Query 600 FKMVPFEELDLDEILKQIDEDREKVRLVMEGKI--SAKVKDLVKSALMIVESPNKARTIA 657 + E DLD+IL +D DR+ +R +MEG++ +A+ DL+++ LM+VESP KARTIA Sbjct 591 AEFKHLGEADLDKILADVDRDRKTIRDIMEGRLVPAARGVDLMRTILMVVESPTKARTIA 650 Query 658 NFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTN-----------------EG 700 NFFG+PS + YEVS G+ +L + AS GH+++L T+ + Sbjct 651 NFFGRPSLIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSLNKIDQRQREVLAKWFGDF 710 Query 701 YHG--------VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDA 752 HG VI++ G F+PVY+ I RCR G +VD + P C Sbjct 711 KHGNYDGENYAVIVKEYG----FVPVYNKIWRCR--GAVYVD--DIDIPPGC------KP 756 Query 753 LDNVKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMK 812 LD ++A+R +A EVD +L+ TDPD+EGEKIA+D+ L PY +I+R+EFHEVTR AI+ Sbjct 757 LDVLEAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRRAILN 816 Query 813 AIQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERY 872 A+ R VN V AQIVRR+EDRWIGF LS+ LQ F+N NLSAGRVQTPVLGWI+ Y Sbjct 817 ALANPRGVNFSLVKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWIVNTY 876 Query 873 KEFSESETYFLGLTLENGLQFTVEIGKDGKEV-EPPEYVTVEKVELEEKEFNPQPPYTTD 931 +E ++ Y + L L N + +++ +D +V + V ++ V E ++ NP PPYTTD Sbjct 877 EESLKNRVYNVELQL-NDVDIRLQVPRDVLDVLRKKKRVAIKLVARERRQVNPPPPYTTD 935 Query 932 AMLKDASTFLKLSAPETMRLAQDLFEAGLC 961 +L+DA L LSA MRLAQDLFE+GL Sbjct 936 ELLRDAVNKLGLSADYAMRLAQDLFESGLI 965 Range 2: 965 to 1217 Score:216 bits(551), Expect:1e-55, Method:Compositional matrix adjust., Identities:122/263(46%), Positives:169/263(64%), Gaps:18/263(6%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGE--EGTHEAIRPTRPIDTGRLM 1507 TYHRTDST VS GI +A+EYI ++ GE FKPR WGE EG HEAIRPTRPID L Sbjct 965 ITYHRTDSTRVSTAGIAIAREYIVRKFGEGVFKPRSWGEAEEGAHEAIRPTRPIDVEELR 1024 Query 1508 QLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVE 1567 LV G+IQL LT++HY+LYD+IFRRFM SQM E +V++ E++G+V Sbjct 1025 GLVNAGVIQLAIQLTKSHYQLYDIIFRRFMASQM-------EPSVVEVAKYNVEIDGHVI 1077 Query 1568 IIED--GWTKLRSPNFRQL----PRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKER 1621 +E G + QL P L G L VV K+++ + ++ SQ D++A+M++R Sbjct 1078 QLERTVGVAYMGFQTLYQLTPVEPELPTGT-LDVV-IKRYRVVR-RVLSQADVLALMRQR 1134 Query 1622 KIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLE 1681 IGRPSTYA I+Q L +RYYV+ T K ++PT +G +++ +L + LVSE++TR +E Sbjct 1135 GIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFRFLKEAFGKLVSEDRTRLIE 1194 Query 1682 EKMDLIEEGKLDYLKVLYDLYNE 1704 + MD IE GK Y +V+ +LY+E Sbjct 1195 QYMDAIEVGKARYEEVIAELYDE 1217 >RecName: Full=Reverse gyrase 1 [Aquifex aeolicus VF5] Sequence ID: O67037.1 Length: 1146 Range 1: 2 to 900 Score:662 bits(1709), Expect:0.0, Method:Compositional matrix adjust., Identities:400/978(41%), Positives:611/978(62%), Gaps:88/978(8%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 +KAI+ +CPNC G IS ERL+ PC++CL E V+ + E+ + N G+ KE+ Sbjct 2 IKAIFDTLCPNCGGEISAERLLKGLPCEKCLPEEVNRE---EVCQKLEN-----GSFKEF 53 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 + S L++ E FF+ G + WS Q++W +++ GRSF+++APTG+GK+TFG MA Sbjct 54 CELLS---ELKDWEDFFKEILGTSPWSLQKSWARKVFLGRSFAMLAPTGVGKTTFGLSMA 110 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQ 180 + A +GKKSYI++PT LV Q +I+ G++ + G L +K+K+E+ +IQ Sbjct 111 SYLAKQGKKSYIILPTQLLVEQVSERIKTF----GVDEDRLIVWGKLSEKKKKELKERIQ 166 Query 181 GEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIG 240 D+DIL+T++ ++ + + E+L + F FIFVDDVD+FLK +KN+D+ LYLLGF+++ I Sbjct 167 KGDFDILITTSMFLYKNY-EILP-KDFSFIFVDDVDSFLKTAKNVDKVLYLLGFSEEDIH 224 Query 241 KAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATG 300 KA+E+I+LK++ +K +++ E++K+ + E+ REI + K+ G++ ++SATG Sbjct 225 KAFELIRLKEKPNK-----SEEDWEEIKKRSEEL----REIAKKKK----GVLAVSSATG 271 Query 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPI 360 + R +RIKL+RELLGFEVG LRN+V++Y + T+++K + + + GKGG++F Sbjct 272 NPRSNRIKLFRELLGFEVGKPSVLLRNIVETY-EETQNLKETLLKRVKEFGKGGLVFVSS 330 Query 361 DQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLP 420 D G EE+ +L G + + ++ ++ FE GEA +G +++ L RG+DLP Sbjct 331 DYGREAVEEVKKFLESHGVK----AVTYEEDLKLFEKGEAQVAIGISSFKNPLARGIDLP 386 Query 421 HLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRK-QAEKLHARLRRLIR 479 H++RYA+F GVPK R + +E + LLS L DE K + +K+ ++RL R Sbjct 387 HVVRYAIFYGVPKIRVPLKVETSVSHLLWALLSLRPIILKDEKLKSEVKKVDTWIQRLRR 446 Query 480 NIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSL 539 + L + E P + + + + +E+ EFL + E++++K+ ++L Sbjct 447 ----YSFLS--DDFVEERP---DLKDRIENLRKEVQEFLLR----EDIVEKIKNSEELTL 493 Query 540 TEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQE 599 E + + + DV Y+QA+GRTSR++AGG+TKGLS ++VD+ + F L +++RW Q+ Sbjct 494 RLGEEGFELVVADVTGYLQASGRTSRMYAGGLTKGLSHVLVDDRRAFKNLEKKVRWFNQD 553 Query 600 FKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANF 659 EE+DL E+L++IDEDR+KVR ++EGK+ A+ K+ VK L++VESPNKARTIANF Sbjct 554 INFKKIEEVDLKEVLREIDEDRKKVREILEGKVKAEQKEHVKPVLVVVESPNKARTIANF 613 Query 660 FGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVY 719 FG+P +IG + EV +G++ + I AS GH+FDLV ++ +HGVI +N +++P+Y Sbjct 614 FGKPMGRKIGGIDVLEVMVGDLYIMITASLGHVFDLVKDKEFHGVIAKNG----EYVPIY 669 Query 720 DTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEG 779 + I+ G N+ VK +RELAQEVD +LI TDPDTEG Sbjct 670 EVIE---------------------GKENI------VKGLRELAQEVDTVLIGTDPDTEG 702 Query 780 EKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIG 839 EKI WD+ +LSPY PN++RIEFHEVTR AI A++ RD NE V AQ+VRRI DRW+G Sbjct 703 EKIGWDLGALLSPYIPNVERIEFHEVTRKAIKHAVENPRDFNENLVKAQLVRRIADRWVG 762 Query 840 FELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENG----LQFTV 895 FE+S+ +Q+ F+ LS GRVQ PVLGWIIER K + + + ENG L F Sbjct 763 FEVSRIVQQAFDKHWLSGGRVQIPVLGWIIEREKLYRKKKHVVQITFKENGRWLRLGFEF 822 Query 896 EIGKDGKEV-EPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQD 954 + K+ KE E + + VE +E E+ NP PP+TTD MLK+AS ++S P+ M+LAQ+ Sbjct 823 QDKKEAKEFYENLKEIDVEVLEEREELKNPPPPFTTDTMLKEASDRYRISVPKLMQLAQE 882 Query 955 LFEAGLCV---TPDTLVS 969 LFE GL T T VS Sbjct 883 LFEYGLITYHRTDSTRVS 900 Range 2: 890 to 1138 Score:201 bits(512), Expect:5e-51, Method:Compositional matrix adjust., Identities:124/258(48%), Positives:166/258(64%), Gaps:12/258(4%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQLV 1510 TYHRTDST VS+ GI VAKE+I++E+G+E F PR WGE G HE IRPT+P+D L ++ Sbjct 890 TYHRTDSTRVSDVGIGVAKEWISEELGKELFYPRVWGEGGAHECIRPTKPLDVEDLRSMM 949 Query 1511 RDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEIIE 1570 G +Q NLTR H LY++IF+RFM SQMK K+ ++ + A + EL EI+E Sbjct 950 LAGQLQ---NLTREHLLLYELIFKRFMASQMKPVKVKTKKVKVKALGREQELILTTEILE 1006 Query 1571 DGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKA-PKVQLYSQGDIIAMMKERKIGRPSTY 1629 +G+ K+ + P LK + V + K+ K+ P LY+QG ++ MK R IGRPSTY Sbjct 1007 EGFNKVYPLELQ--PDLK--GSVYVEDKKELKSVPMAYLYTQGSLVEEMKRRGIGRPSTY 1062 Query 1630 AKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYK--DLVSEEKTRSLEEKMDLI 1687 A IV LL+R YV E G L+PT G +VY +L ++ K VSEE TR LEE MD + Sbjct 1063 ATIVSKLLERGYVIERHGF--LIPTKLGKQVYEFLKSREKIMPFVSEEFTRKLEELMDKV 1120 Query 1688 EEGKLDYLKVLYDLYNEI 1705 EEGK DYL+VL +LY ++ Sbjct 1121 EEGKEDYLQVLDELYKKV 1138 >RecName: Full=Reverse gyrase 2 [Sulfurisphaera tokodaii str. 7] Sequence ID: Q975P6.2 Length: 1233 Range 1: 9 to 970 Score:628 bits(1619), Expect:0.0, Method:Compositional matrix adjust., Identities:392/1016(39%), Positives:583/1016(57%), Gaps:96/1016(9%) Query 5 YREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWERIY 64 Y CPNC IS ERL + C ECL+E +S EL+ + L + R+ Sbjct 9 YLSSCPNCGRVISAERLYKGSVCSECLEEDREFNSIRELVNEL-------SRLNKLNRLN 61 Query 65 SLEKNLREIEGF---FERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAV 121 +++ LRE + F F+R GF + Q++W+ R+L+ SF+IIAP G+GK+TFG ++ Sbjct 62 YIKEVLREYDIFVELFKRIIGFPPFGPQKSWIIRVLRKESFAIIAPPGLGKTTFGIITSL 121 Query 122 WHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQG 181 + ++K +S ++ PT LV Q V +I + + IE L YYH + + +K+E+ + Sbjct 122 YFSSKNFRSILIFPTRSLVKQAVDRISMYSNKTNIETKLLYYHSGINESQKQELYKALNA 181 Query 182 EDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIGK 241 D++I + + ++ K +E LK +DF+FVDDVD LK+SK+ + L L GF+ D I Sbjct 182 GDFNIFIATNRFFIDKINE-LKNIKYDFMFVDDVDTALKSSKSAETILNLAGFSKDDILS 240 Query 242 AWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKI-GIMIIASATG 300 E+++ K +E S +++Q EI R NK+ G I+ S+ Sbjct 241 VKELLR------------------KSREDESVYTKIQ-EI----RGNKLKGKTIVFSSAT 277 Query 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYL---KPTRDIKGHVEELLTMLGKGGIIF 357 RG+ + L+GF GS LR ++D+Y D+ ++ELL LG+GG+IF Sbjct 278 LTRGNPV--LSALMGFRPGSSVIYLRKIIDTYAYLPNNDDDVVNLLKELLNKLGEGGLIF 335 Query 358 TPIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGL 417 P+D+G YA+ L L + F V ++S N IE F NG L+GSAT+YG LVRG+ Sbjct 336 VPVDKGQEYAKFLEAKLSD-SFNVVTITSSNTNKIEDFANGNIYALIGSATHYGILVRGI 394 Query 418 DLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRL 477 D+P ++YA+F G+PKF+F I E + +LS I D+D +L R+R Sbjct 395 DIPWRVKYAIFVGIPKFKFKIG-EVMNLVALSRILSMIGLITKDQD---IVRLAGRVRGK 450 Query 478 IRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAE--DP 535 +R + + + EG +E+E E + K L D+++LKK+AE D Sbjct 451 LRKLSPAAISMLTNQAREG-KLEDE-------TLLRAYEVVNKYLEDKDILKKIAELGDL 502 Query 536 FVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMR- 594 +S YI +PD TYIQA+GRTSR++ G +T GLSVL++D+ +FN L R++ Sbjct 503 VIS------NGYILMPDYLTYIQASGRTSRIYGGELTTGLSVLLIDDINLFNILNRKLSL 556 Query 595 ------WRFQEFKMVPFEELDLDEILKQIDEDREKV-RLVMEGKISAKVKDLVKSALMIV 647 W+ + K DL EI+ +I+E+RE++ ++ EG+I ++ VK+ L IV Sbjct 557 ILDEIIWQELQIKKNKIGSSDLTEIINKINEERERILKVKKEGEIEPSLQK-VKTVLFIV 615 Query 648 ESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVT-NEGYHGVII 706 ESPNKA+TI+NFF +PS ++ ++ A+E + + +L + A+GGH++DL T N G +GV + Sbjct 616 ESPNKAKTISNFFAKPSIRQLENIRAFETVLEDKILIVAATGGHVYDLTTQNIGIYGVEV 675 Query 707 QNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNV-RDALDNVKAMRELAQE 765 Q + FIP Y+TIK+C + GHQF D+EQ CP+C +T + D + A+R+LA E Sbjct 676 QQQNSHFNFIPYYNTIKKCIN-GHQFTDFEQGNQCPKCHTTQIILDKTATIDALRKLALE 734 Query 766 VDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRV 825 DEILI TDPDTEGEKIAWDI L P+ NIKR EFHEVTR AI++AI R N V Sbjct 735 ADEILIGTDPDTEGEKIAWDIYLALKPFNSNIKRAEFHEVTRKAILQAINNPRPFNVNLV 794 Query 826 NAQIVRRIEDRWIGFELSQELQRVF-------------ENRNLSAGRVQTPVLGWIIERY 872 +QIVRRIEDRWIGF+LS +LQ F EN+NLSAGRVQ+PVL WI+ RY Sbjct 795 KSQIVRRIEDRWIGFKLSTKLQEDFWKEYCKNYNCKSEENKNLSAGRVQSPVLNWIVNRY 854 Query 873 KEFSESET--YFLGLTLENGLQFTVEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTT 930 E++ ++T Y+ + + L+F V + YV + ++ E+E NP PPYTT Sbjct 855 DEYNANKTKIYYGSIKGIDELKFYVFKQNEKIRKNANIYVKIINTKVLEEEINPLPPYTT 914 Query 931 DAMLKDASTFLKLSAPETMRLAQDLFEAGLCV--------TPDTLVSLSDGRIMEI 978 D +L DA+ F +SA ETM++AQDLFE GL +T +S+++G + +I Sbjct 915 DTLLYDANQFYGISASETMKIAQDLFELGLITYHRTDSTRISNTGISIAEGYLKQI 970 Range 2: 946 to 1229 Score:220 bits(560), Expect:1e-56, Method:Compositional matrix adjust., Identities:126/284(44%), Positives:176/284(61%), Gaps:29/284(10%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEY---FKPRHWGEEGTHEAIRPTRPIDTGRLM 1507 TYHRTDST +SNTGI +A+ Y+ Q GE Y FKPR WGE G HEAIRPTRP+D +L Sbjct 946 TYHRTDSTRISNTGISIAEGYLKQIAGENYTKIFKPRSWGEGGAHEAIRPTRPLDVDQLR 1005 Query 1508 QLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMER---AVIDAGVGKAEL-- 1562 LV +G I+L K +TR H+ +YD+IFRRF+TSQ+ K++ ER + + +EL Sbjct 1006 LLVDEGEIELAKKITRAHFLIYDLIFRRFITSQLVPLKVIKERIEYKICEDSNCNSELKT 1065 Query 1563 -EGYVEIIEDGW--TKLRSPNFRQLP-----------RLKE-----GAKL--KVVEAKKW 1601 + Y E I D +L F LP +L+E A+L K+ + Sbjct 1066 LQNYSEFITDIKLPIQLDYSKFLYLPTTRIIKNSIIKKLQETTGSTNAELVSKIQLTGSF 1125 Query 1602 KAPKVQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVY 1661 V LY+Q +++A MK ++IGRPSTYA I+ T+L+R YV E++ KKL+PT G +V Sbjct 1126 VKSTVNLYTQAELVAEMKRKEIGRPSTYATIISTILKRGYVIESKKTKKLIPTQLGKEVN 1185 Query 1662 HYLVTKYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEI 1705 YL K+ VSEE+TR+L + MD++E+GK DY+++L D+Y EI Sbjct 1186 KYLNQKFSSFVSEERTRNLLQLMDMVEQGKQDYIQILKDIYYEI 1229 >RecName: Full=Reverse gyrase 1; AltName: Full=TopR1 [Saccharolobus solfataricus P2] Sequence ID: Q97ZZ8.1 Length: 1242 Range 1: 10 to 962 Score:622 bits(1605), Expect:0.0, Method:Compositional matrix adjust., Identities:385/1007(38%), Positives:580/1007(57%), Gaps:103/1007(10%) Query 3 AIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWER 62 +IY CPNC G IS +RL N + C+ CL + D F ++ + N L LK + Sbjct 10 SIYTRSCPNCGGNISSQRLFNGSVCESCLKD----DREFSNLSDLINILSENSNLKNLTQ 65 Query 63 IYSLEKNLREIEGFFERATGFTF-WSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAV 121 I + + +++E F + + QR+W R L+G SF+IIAP G+GK+TFG M++ Sbjct 66 IRDVLEEYKKVEEIFGKLLNNSKPIGPQRSWTIRFLRGESFAIIAPPGLGKTTFGLIMSL 125 Query 122 WHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQG 181 ++AT+ +KS I+ PT L+ QTV K+ +E + Y + + E +L +++ Sbjct 126 YNATRNRKSIIIFPTRTLISQTVDKLAKFSELYSYSPRILYNKQS--PTQTENILDQLKS 183 Query 182 EDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIGK 241 ++DI +++ +++ + E L FDFIFVDDVDA LK+ K+ L L+GF D+ I Sbjct 184 GNFDIFISTNRFVIQNLSE-LSNIKFDFIFVDDVDAALKSGKSAKAILRLVGFTDEDIQT 242 Query 242 AWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATGS 301 ++++ EEK ++ +EI E + ++KI +I +SAT S Sbjct 243 TMKLLR-----------ENIGEEEKFGKI--------QEIRESRLKDKI--VIFSSATIS 281 Query 302 ARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGH---------VEELLTMLGK 352 RG+ I L+GF GS LRN+ DSY+ T+ KG V +LL L Sbjct 282 -RGNPI--LSSLMGFRPGSSVIYLRNIYDSYIDLTQTCKGQDFEECTLGTVIKLLKRLND 338 Query 353 GGIIFTPIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGS 412 G +IF PID+G YA+ L + LR+ G VE V+S + +E+FE GE LVG AT+YG Sbjct 339 GTLIFVPIDKGAQYADYLASNLRDHGINVESVASSSISKLEKFERGEVSSLVGVATHYGV 398 Query 413 LVRGLDLPHLIRYAVFTGVPKFRFSI-DLERPTIYRALGLLSEIMDFLSDEDRKQAEKLH 471 LVRG+DLP ++Y++F G+PKF+F I + P AL L ++ + ++D+ + L Sbjct 399 LVRGIDLPWRVKYSIFVGIPKFKFKIGEYMHPL---ALTRLLSLVYLVKNDDKVRG--LL 453 Query 472 ARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKL 531 + +R+ +R I L + + + EG I++E +E + + L D E LKK+ Sbjct 454 SYIRKRLRKISPAALAMLAKDIREG-KIDDE-------RLKEAYNLVNEYLKDNEFLKKV 505 Query 532 AEDPFVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVR 591 ++ V EG YI +PD TYIQA+GRTSRL+ +T GLSVL++DN ++F L + Sbjct 506 SD---VGDLVIEGD-YILMPDYLTYIQASGRTSRLYGANLTTGLSVLLIDNSRLFELLNK 561 Query 592 -------QMRWRFQEFKMVPFEELDLDEILKQIDEDREKV-RLVMEGKISAKVKDLVKSA 643 +++W + ++ L +I +I E+RE + ++ EG + + VK+ Sbjct 562 KLNLILDEVKWYSLDIDADKLGQVSLSDISAKITEERESLSKIKKEGNVESSSLS-VKTT 620 Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVT------ 697 L IVESPNKA+TI+NFF +PS G L YE +G+ +L + ASGGH++DL+T Sbjct 621 LFIVESPNKAKTISNFFSRPSTRSYGKLRVYETVLGDRVLIVAASGGHIYDLITEDESEK 680 Query 698 -NEGY-HGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDN 755 ++ Y +GV++++ KFIP+Y TIK+C + GHQ V + CP CGS V D + Sbjct 681 QDDNYVYGVLVKDS----KFIPIYSTIKKC-EKGHQIVKDLSQNKCPICGSRIVTDKTEV 735 Query 756 VKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQ 815 V +R+LA EVDE+LI TDPDTEGEKIAWDI + P+ NIKR EFHEVTR AI+ AI+ Sbjct 736 VDILRKLALEVDEVLIGTDPDTEGEKIAWDIYLAIRPFNGNIKRAEFHEVTRRAILNAIK 795 Query 816 EARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVF-------------------ENRNLS 856 R+ N+ V +QIVRRIEDRWIGF+LS++LQ F ENRNLS Sbjct 796 NPREFNDNLVKSQIVRRIEDRWIGFKLSRKLQTEFWEQHCTSISKKNSKDEECKENRNLS 855 Query 857 AGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQF---TVEIGKDGKEVEPPEYVTVE 913 AGRVQTPVL W++ RY++++E++ +L + ++ F + + K+G + +E Sbjct 856 AGRVQTPVLDWVVNRYQKYNENKKKYLIIESQDKSIFPFSVLALKKNGLSKNTQIIIHLE 915 Query 914 KVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL 960 + ++E+EF P PPYTTD +L DA+ L++ A +TMR+AQDLFE GL Sbjct 916 DINIKEEEFGPLPPYTTDTLLSDAANLLRIPASDTMRVAQDLFELGL 962 Range 2: 964 to 1238 Score:202 bits(513), Expect:5e-51, Method:Compositional matrix adjust., Identities:114/277(41%), Positives:168/277(60%), Gaps:24/277(8%) Query 1451 TYHRTDSTHVSNTGIEVAKEYI-TQEVG-EEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQ 1508 TYHRTDST VSN GI VA+ Y+ +++V + F+PR WGE G HEAIRPT+P+D L Sbjct 964 TYHRTDSTRVSNVGISVAETYLKSKQVDISKIFRPRSWGEGGAHEAIRPTKPLDETMLKA 1023 Query 1509 LVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDA------------- 1555 + G ++L K LT NH+R+Y++IFRRF+TSQ+ + + I A Sbjct 1024 SIEQGDLELSKQLTFNHFRVYNLIFRRFITSQLPPLVVTKQIVRIRAYTKDNIELELDEN 1083 Query 1556 ------GVGKAELEGYVEIIEDG-WTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQL 1608 G E + + + ++D +T R ++ L +G +L VQL Sbjct 1084 KKEFVIGYKLKEGDEFRQTLQDAIYTLFRL--YQPLDEKMKGKELSATITGTLNKSDVQL 1141 Query 1609 YSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKY 1668 Y++G++I+ MK ++IGRPSTYA I+ TL +R Y+ E++ KK++PT G+ V YL+ Y Sbjct 1142 YTEGELISEMKSKQIGRPSTYAVIISTLKKRRYIIESKNLKKIIPTKLGMAVKEYLMENY 1201 Query 1669 KDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEI 1705 K +VSE++T L EKM+ +EEGK+DYL +L +LYNEI Sbjct 1202 KQIVSEKRTVKLLEKMNEVEEGKVDYLVLLKELYNEI 1238 >RecName: Full=Reverse gyrase 1 [Sulfolobus acidocaldarius DSM 639] Sequence ID: Q08582.3 Length: 1248 Range 1: 10 to 962 Score:598 bits(1542), Expect:0.0, Method:Compositional matrix adjust., Identities:367/993(37%), Positives:568/993(57%), Gaps:75/993(7%) Query 3 AIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWER 62 +IY CPNC IS RL+ + C+ CL+E D ++ I + ++ +G L + + Sbjct 10 SIYLFSCPNCGRSISTYRLLLGSVCNICLEE----DKEYKNIGDLIKDIEKQGNLIKLKD 65 Query 63 IYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVW 122 I + + F R GF + Q++W+ RLL G SF+IIAP G+GK+TFG +++ Sbjct 66 IQRVLDDYESFVSVFRRLLGFPPFGPQKSWIYRLLSGESFAIIAPPGLGKTTFGLISSIY 125 Query 123 HATKGKKSYIVVPTTPLVIQTVRK----IQAVAERAGIEINLAYYHGNLRKKEKEEMLAK 178 +GKKS +V PT LV Q + K IQ +AE + YY+ + E++E Sbjct 126 LYLRGKKSILVFPTKSLVRQAIDKLSSYIQNLAEIKENPPKVIYYYSGMSASERKEADEG 185 Query 179 IQGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDI 238 +Q + +DI +++ +++ D++ + F+FVDDVD LK+SK+ L LLGF Sbjct 186 LQSKTFDIFISTNRFLIDNIDQI-SSTSYQFLFVDDVDTALKSSKSAQAILKLLGFTPS- 243 Query 239 IGKAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASA 298 + K+K+ + KY RE K N + + EI++ +++ +I S+ Sbjct 244 -----DQDKIKESLKKY-------RENTQK--NEQNEYIFEEIDKIRKDRLASKTVIFSS 289 Query 299 TGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLK-PTRDIKGH--VEELLTMLGKGGI 355 R + I L+GF+ GS +R V D Y+K P ++ + ++ LL LG GG+ Sbjct 290 ATLNRSNPI--LTSLVGFKPGSSVIYIRKVYDMYVKQPDKEQETFNLIKSLLHRLGDGGL 347 Query 356 IFTPIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVR 415 IF P+D+ Y + L + L F V ++S + I+ F NGE D L+GSAT+YG LVR Sbjct 348 IFVPVDKKQEYIKRLQSELSNE-FNVAAITSTSATKIDDFANGEIDVLIGSATHYGILVR 406 Query 416 GLDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLR 475 GLDLP ++Y++F G+PKF+F + E+ + LLS I D+ + + R++ Sbjct 407 GLDLPWRVKYSIFVGIPKFKFRLG-EKVNLLTLSRLLSLIALITKDQ---EVIYISRRVK 462 Query 476 RLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDP 535 IR + L + EG +E+ + + + L K L ++ VLK+++E Sbjct 463 DKIRRLSPAALTMLSVQAKEG-KLED-------SILLKAYDLLNKYLSNQNVLKRISEIG 514 Query 536 FVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMR- 594 L+ + I IPD TY+QA+GRTSR++AG +T GLS+L+VD+ +F L ++++ Sbjct 515 DFVLSPDND---ILIPDYLTYVQASGRTSRIYAGDVTTGLSILLVDDFNLFRLLNKKLQY 571 Query 595 ------WRFQEFKMVPFEELDLDEILKQIDEDREKV-RLVMEGKISAKVKDLVKSALMIV 647 WR + + ++++ ++ +I+E+R ++ +L EG ++ ++ VK+ L++V Sbjct 572 ILDDIQWRELDVEKWTAGDVEIKNLISKINEERNEISKLKNEGNVAPALQK-VKTVLLVV 630 Query 648 ESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNE-GYHGVII 706 ESPNKA+TI++FF +PS +IG++ YE +G+ +L + ASGGH++DL T + G +GV I Sbjct 631 ESPNKAKTISSFFSRPSIRQIGNMRVYETVLGDKVLMVTASGGHVYDLTTQDMGIYGVDI 690 Query 707 QNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVR-DALDNVKAMRELAQE 765 + L FIP+Y++IK+C + HQF D+ + CPRC +T VR D+L ++ +R LA E Sbjct 691 MKQNSSLVFIPIYNSIKKCEN-NHQFTDFFESNKCPRCMTTKVRYDSLKSINVLRNLAVE 749 Query 766 VDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRV 825 DE+LI TDPDTEGEKIAWD+ L PY NI+R EFHEVTR AI++AI + R+ N V Sbjct 750 ADEVLIGTDPDTEGEKIAWDLYLALRPYNSNIRRAEFHEVTRKAILQAINQPREFNVNLV 809 Query 826 NAQIVRRIEDRWIGFELSQELQRVF-----------------ENRNLSAGRVQTPVLGWI 868 +Q+VRRIEDRWIGF+LS LQ F EN+NLSAGRVQTPVL WI Sbjct 810 KSQLVRRIEDRWIGFKLSSILQTRFWPEYCKSLSSNKQLNCNENKNLSAGRVQTPVLSWI 869 Query 869 IERYKEFSESETYFLGLTLENGLQFTVEIGK-DGKEVEPPEYVTVEKVELEEKEFNPQPP 927 ++RY E+ +++ ++ + + K DG V ++ E+EF P PP Sbjct 870 VDRYTEYQRNKSRVYYGKIDQLQDIVIYVPKQDGVRKNSKIVVVFNEINQLEEEFGPLPP 929 Query 928 YTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL 960 YTTD +L D++ F LSAPETMR+AQDLFE GL Sbjct 930 YTTDTLLSDSNNFFGLSAPETMRIAQDLFELGL 962 Range 2: 899 to 1244 Score:186 bits(471), Expect:5e-46, Method:Compositional matrix adjust., Identities:128/348(37%), Positives:193/348(55%), Gaps:44/348(12%) Query 1400 PEKEFLKSLVEAGVTWVKVKEVEEEHYTGKLYDFTTTT-----ENFLSNGA-----VSHN 1449 P+++ ++ + V + ++ ++EEE G L +TT T NF A ++ + Sbjct 899 PKQDGVRKNSKIVVVFNEINQLEEEF--GPLPPYTTDTLLSDSNNFFGLSAPETMRIAQD 956 Query 1450 ------CTYHRTDSTHVSNTGIEVAKEYITQEVGEEY---FKPRHWGEEGTHEAIRPTRP 1500 TYHRTDS +SNTGI VA+ Y+ +G++Y FKPR WG+ G HE IRPT+P Sbjct 957 LFELGLITYHRTDSNRISNTGISVAENYLKDVLGDKYTNIFKPRSWGDGGAHEGIRPTKP 1016 Query 1501 IDTGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDA-GVGK 1559 ID +L L+ +G ++L K LT NH+++YD+IFRRF++SQ+ K+ E I+ G K Sbjct 1017 IDVEQLRLLIEEGELELAKRLTNNHFKVYDIIFRRFISSQIIPLKVRKEIVKIELYGENK 1076 Query 1560 AE----------------LEGY-VEIIEDGWTKLRSPNFRQLPRLKEGAK-----LKVVE 1597 E L G EI + + +R+ + RLKE + + Sbjct 1077 KEKINSNQNIIEVITGITLPGIDTEISKFAYVPVRNVSRSVAERLKELGRSIPTDFSIEI 1136 Query 1598 AKKWKAPKVQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKG 1657 + + V LY+Q D++ MK +KIGRPSTYA I+ T+L+R YV E+ KKL+PT G Sbjct 1137 SNSFIKSTVNLYTQADLVMEMKNKKIGRPSTYATIIGTILRRGYVLESLKTKKLIPTRLG 1196 Query 1658 IKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEI 1705 ++V YL Y VSE++TR L + MD++E G+ Y +VL +Y EI Sbjct 1197 VEVNKYLNENYGRFVSEDRTRKLLQLMDMVEAGQEKYEEVLKQVYEEI 1244 >RecName: Full=Reverse gyrase [Archaeoglobus fulgidus DSM 4304] Sequence ID: O29238.1 Length: 1054 Range 1: 43 to 824 Score:593 bits(1530), Expect:0.0, Method:Compositional matrix adjust., Identities:365/911(40%), Positives:535/911(58%), Gaps:134/911(14%) Query 70 LREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHATKGKK 129 L+E FF + G + Q+ W KR+L+ SF+ APTG+GK++FG M+++ A KGK+ Sbjct 43 LKEFVEFFRKCVGEP-RAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFLALKGKR 101 Query 130 SYIVVPTTPLVIQTVRKIQAVAERAGI--EINLAYYHGNLRKKEKEEMLAKIQGEDYDIL 187 Y++ PT+ LVIQ I+ AE+AG+ E + YYHG + K+EKE + ++ ++ I+ Sbjct 102 CYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLR--NFKIV 159 Query 188 VTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIGKAWEIIK 247 +T+ Q++++ + E+ HFDFIFVDDVDA LKASKN+D+ L+LLGF+ D+ K+W Sbjct 160 ITTTQFLSKHYREL---GHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTKSW---- 212 Query 248 LKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATGSARGDRI 307 G A+ G +++++AT + +G + Sbjct 213 ---------VGEAR-----------------------------GCLMVSTAT-AKKGKKA 233 Query 308 KLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPIDQGLGYA 367 +L+R+LL F++GS R +RNV D + + + +L LG GGII+ + A Sbjct 234 ELFRQLLNFDIGSSRITVRNVEDVAVND--ESISTLSSILEKLGTGGIIYARTGEE---A 288 Query 368 EELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLPHLIRYAV 427 EE+ L+ + FR+ +V++ K E+F GE D+L+G+A YYG+LVRGLDLP IR+AV Sbjct 289 EEIYESLKNK-FRIGIVTATKKGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAV 347 Query 428 FTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRNIPQFELL 487 F G P FR +I E +D LS Q KL L L RN+ + E L Sbjct 348 FVGCPSFRVTI---------------EDIDSLS----PQMVKL---LAYLYRNVDEIERL 385 Query 488 KIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLTEEEGKWY 547 LP H+ E+ E L+K + E + A+D V EG+ Sbjct 386 ---------LP---AVERHI----DEVREILKKVMGKE---RPQAKDVVV----REGE-- 420 Query 548 IEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEE 607 + PD+RTYIQ +GRTSRLFAGG+TKG S L+ D+ ++ + + + + EFK + +E Sbjct 421 VIFPDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIERAKLYDIEFKSI--DE 478 Query 608 LDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPSKTR 667 +D +++ +++DE R++ R E DL+K AL IVESP KAR I+ FFG+PS Sbjct 479 VDFEKLSRELDESRDRYRRRQEF-------DLIKPALFIVESPTKARQISRFFGKPSVKV 531 Query 668 IGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYDTIKRCRD 727 + V YE+ + +L + AS GH+ DL+TN G+HGV++ +F+PVY +IKRCRD Sbjct 532 LDGAVVYEIPMQKYVLMVTASIGHVVDLITNRGFHGVLVNG-----RFVPVYASIKRCRD 586 Query 728 CGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGEKIAWDIR 787 CG+QF E + CP+CGS NV ++ ++A+R+LA + + +++ TDPDTEGEKIAWD++ Sbjct 587 CGYQFT--EDRESCPKCGSENVDNSRSRIEALRKLAHDAEFVIVGTDPDTEGEKIAWDLK 644 Query 788 NVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQ 847 N+LS +KR EFHEVTR AI++A++ RDV+E V AQ+VRRIEDRWIGF LSQ+L Sbjct 645 NLLSG-CGAVKRAEFHEVTRRAILEALESLRDVDENLVKAQVVRRIEDRWIGFVLSQKLW 703 Query 848 RVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQFTVEIGKDGKEVEPP 907 F NRNLSAGR QTPVLGWII+R++E E + F + + D +E + Sbjct 704 ERFNNRNLSAGRAQTPVLGWIIDRFQESRERRKIAI------VRDFDLVLEHDEEEFD-- 755 Query 908 EYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCV---TP 964 +T++ VE E+ P PPYTT+ ML DA+ LK S +TM++AQ+LFE GL T Sbjct 756 --LTIKLVEEREELRTPLPPYTTETMLSDANRILKFSVKQTMQIAQELFENGLITYHRTD 813 Query 965 DTLVSLSDGRI 975 T VS RI Sbjct 814 STRVSDVGQRI 824 Range 2: 798 to 1050 Score:198 bits(504), Expect:3e-50, Method:Compositional matrix adjust., Identities:119/278(43%), Positives:159/278(57%), Gaps:34/278(12%) Query 1437 TENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIR 1496 + NG + TYHRTDST VS+ G +AKEY+ + F R WGE G HE IR Sbjct 798 AQELFENGLI----TYHRTDSTRVSDVGQRIAKEYLGDD-----FVGREWGESGAHECIR 848 Query 1497 PTRPIDTGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAG 1556 PTRP+ + +L+++G++ + + L H+ LYD+IFRRFM SQ + K+++++ I+ Sbjct 849 PTRPLTRDDVQRLIQEGVL-VVEGLRWEHFALYDLIFRRFMASQCRPFKVVVKKYSIEFD 907 Query 1557 VGKAELEGYV-------EIIEDGWTKLRSPN--FRQLPRLKEGAKLKVVEAKKWKAPKVQ 1607 AE E V E+ W K P FR V+A+ PKV Sbjct 908 GKTAEEERIVRAEGRAYELYRAVWVKNELPTGTFR-------------VKAEVKSVPKVL 954 Query 1608 LYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTK 1667 ++Q +II MMKER IGRPSTYA IV L R YV E GR ++PT GI V+ +LV + Sbjct 955 PFTQSEIIQMMKERGIGRPSTYATIVDRLFMRNYVVEKYGR--MIPTKLGIDVFRFLVRR 1012 Query 1668 YKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEI 1705 Y VSE++TR LE +MD IE G+LDYLK L DLY EI Sbjct 1013 YAKFVSEDRTRDLESRMDAIERGELDYLKALEDLYAEI 1050 >RecName: Full=Reverse gyrase 2 [Aquifex aeolicus VF5] Sequence ID: O67226.2 Length: 1159 Range 1: 10 to 898 Score:585 bits(1508), Expect:0.0, Method:Compositional matrix adjust., Identities:375/965(39%), Positives:548/965(56%), Gaps:90/965(9%) Query 9 CPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWERIYSLEK 68 CPNC G IS +RL PC +CL +P V +AL+ TLK + +K Sbjct 10 CPNCGGVISSDRLEKGLPCSKCLPKPTEE--------KVCDALEELKTLKYLKPFCDTDK 61 Query 69 NLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHATKGK 128 +L FFE+A G WS QR W KR+ +SF+I+APTG+GK+TFG M+++ KG+ Sbjct 62 SLERFINFFEKAVGAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLF--LKGR 119 Query 129 KSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQGEDYDILV 188 + PT L Q ++ +A++ G+ + Y +K +E+ L D+DIL+ Sbjct 120 -VLAIFPTRLLAQQAGDRLSELAQKVGVNKKILIYQS--KKNIREQFL----NGDWDILL 172 Query 189 TSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIGKAWEIIKL 248 + ++ + F+ ++ + F IF+DD+D+FLK KN+D LLGF+ E IKL Sbjct 173 GTNMFLHKNFENLINFK-FKLIFIDDIDSFLKRGKNVDYLFKLLGFSG-------EEIKL 224 Query 249 KKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATGSARGDRIK 308 + +K R DR ++R+++ KR+ ++I++SAT RG R Sbjct 225 ALKENK--TQRDYDR----------LARIRKR----KRDT---VLIVSSATLKPRGKRAY 265 Query 309 LYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVE---ELLTMLGKGGIIFTPIDQGLG 365 L+R LLGF+V + LRN+VD +P +D++ +E EL+ LGKGG+++ + G Sbjct 266 LFRNLLGFDVQKAITTLRNIVDV-AEPVKDLEEALEKSVELIKKLGKGGLVYLSVFYGKD 324 Query 366 YAEELVNYLRERGFR-VELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLPHLIR 424 +E+ + R+ G V + K ++ + E GE D VG + LVRG+DLPH+IR Sbjct 325 KVQEVKEFYRKHGINAVSYLDYKPEELYQILEKGEFDVAVGISHITNPLVRGIDLPHIIR 384 Query 425 YAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRNIPQF 484 YAVF PK F +L LL+ + F D DR +A + L+R Sbjct 385 YAVFLDPPKHVFPTELTLSPPLLHGLLLTLLNLFEGD-DRLKAIQYVMYLKRY------- 436 Query 485 ELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLTEEEG 544 L + E + P + E+ FL L DE LKK+ E +SL +EG Sbjct 437 --LTLREEQLDNYP-------RIKERVEEIKNFLENYLKDENFLKKIKESEDISLVPKEG 487 Query 545 KWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRF--QEFKM 602 K YI + D +YIQA+GRTSR AGG+TKGLSV+ + K F L +++ + QE + Sbjct 488 KLYIVVGDANSYIQASGRTSRFIAGGMTKGLSVVYYSDPKAFYSLKKRLALYYMTQEIEF 547 Query 603 VPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQ 662 E+DL++++K+IDEDR++ R +++GK A++KDL K+ L+IVESPNKARTIA FFG+ Sbjct 548 KRLSEVDLNKLIKEIDEDRKRAREILQGKGVAQIKDLFKTTLVIVESPNKARTIAGFFGK 607 Query 663 PSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYDTI 722 P + D VAYEV +G+ +L I AS GH+ DLVT++G+ GV+ + ++PVYDTI Sbjct 608 PQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFFGVL----DDTYPYLPVYDTI 663 Query 723 KRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGEKI 782 K CR+ Q ++E + RC + D L+ +K +RE++ EVDE+ IATDPD EGEKI Sbjct 664 KICRETHEQHTEYEY--LKKRCKG-KIEDKLEIIKGVREVSYEVDEVFIATDPDAEGEKI 720 Query 783 AWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGFEL 842 +D+ + P+ NIKR EFHEVT A +AIQ R+V+ V AQ+VRRI DRW+GF L Sbjct 721 GYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPREVDLNLVKAQLVRRILDRWVGFTL 780 Query 843 SQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESE--------TYFLGLTLENGLQFT 894 S L F + LSAGRVQTPVLGW+I+RY+E E + + L + +E+ L F Sbjct 781 SHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKEKKGEILLHVNDFPLKIEIED-LMFA 839 Query 895 VEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQD 954 EI KD E + +E+E P PPYTTD +L+DA+ L LSA +TM++ Q+ Sbjct 840 KEIFKD------LELADISLSNPQEEEKRPLPPYTTDTVLEDANEKLHLSAHKTMKILQE 893 Query 955 LFEAG 959 LFEAG Sbjct 894 LFEAG 898 Range 2: 901 to 1145 Score:206 bits(524), Expect:2e-52, Method:Compositional matrix adjust., Identities:116/253(46%), Positives:160/253(63%), Gaps:9/253(3%) Query 1451 TYHRTDSTHVSNTG-IEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQL 1509 TYHRTDST VS+ G VAK YIT+ GEEYF PR WGE G HE IRPTRP++ L + Sbjct 901 TYHRTDSTRVSDAGKYLVAKPYITKMFGEEYFYPRSWGEGGAHECIRPTRPLEPKDLEFM 960 Query 1510 VRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEII 1569 + GI + N ++Y++IF+RFM SQM+ AK++ E ++ + + E+ Sbjct 961 ITAGIAEFED--PENALKVYELIFKRFMASQMRPAKVITEEIILKLPYFEWKERVVTEVK 1018 Query 1570 EDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTY 1629 E G+ L P F+ P+ KL++ + + PKV Y+QG +I MK R +GRPSTY Sbjct 1019 EHGFD-LMYPTFKVFPK---KEKLEITHKEFREVPKVYPYTQGTLIQEMKRRGLGRPSTY 1074 Query 1630 AKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEE 1689 A+IVQTLL+R+YV E +G L+PTD G +VY YL + + SEE TR LEE MD IE Sbjct 1075 AQIVQTLLERHYVVEEKGF--LIPTDLGREVYEYLTKHFPEWTSEELTRKLEEAMDKIER 1132 Query 1690 GKLDYLKVLYDLY 1702 G+LDY++VL +++ Sbjct 1133 GELDYMEVLKEVH 1145 >RecName: Full=Reverse gyrase 2 [Aeropyrum pernix K1] Sequence ID: Q9YC75.2 Length: 1215 Range 1: 5 to 940 Score:558 bits(1438), Expect:1e-172, Method:Compositional matrix adjust., Identities:360/972(37%), Positives:519/972(53%), Gaps:48/972(4%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 + A+Y +C NC G I ++RL PC CL P + V ALK GTL + Sbjct 5 VNAVYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPRRATPL----TVYRALKKAGTLGAY 60 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 Y + + E +F +G WSAQR+W KRL+KG SF+IIAPTG+GKST A Sbjct 61 SWEYLSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYA 120 Query 121 VWHAT--KGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAK 178 + A +G+ Y+V PT LV Q K+ V I AYY + K +E L K Sbjct 121 AYVAAVKRGRVLYLV-PTENLVRQVYAKLDQVEP----GIATAYYS-RMPAKARESSLEK 174 Query 179 IQGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDI 238 I ++V + +++R+FD + FD VDDVD+ L+ S+N++R L L GF+++ Sbjct 175 IASGGARLIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEET 234 Query 239 IGKAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASA 298 + A ++K + ++ + L+ A E + L EI++L+ + E G ++IASA Sbjct 235 VEAAHSLVKARLKLYRALHSGAS--ESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASA 292 Query 299 TGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFT 358 TG RG + L++ELLGFEVG G LRN+VD+Y+ + D G E+++ LG G I+F Sbjct 293 TGRPRGVKHLLFKELLGFEVGGGSDYLRNIVDAYVVDS-DPVGRTAEIVSALGDGVIVFV 351 Query 359 PIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLD 418 G A + L G L + ++ +E F GEA L+G A+ YG +VRGLD Sbjct 352 SQRLGKDVARAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLD 411 Query 419 LPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLI 478 LP +YAVF G P + + LE AL ++ FLS K E RRL Sbjct 412 LPERSKYAVFLGAPSAKTHL-LE------ALYSPRRMLAFLSIAQEKGVEWAGEAFRRLS 464 Query 479 RNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVS 538 R + + I A G G+ E L L E L+ Sbjct 465 RLLEKVIDTSIVSLAARGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGL 524 Query 539 LTEEEGKW-YIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRF 597 + + G Y+ +PD TYIQA+GR SRL+ G +T+GLS+++ + + L +++W Sbjct 525 VVDARGPIPYLVVPDAPTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWTT 584 Query 598 QEFKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIA 657 ++ P E+D++++ ++I+E + + VK+ L++VESP KARTIA Sbjct 585 SS-RLRPLSEVDMEKLRREIEES----------RRGKGRRVRVKTTLLVVESPTKARTIA 633 Query 658 NFFGQPSKTRIGDLVAYEVSIGN------MMLTILASGGHMFDLVTNEGYHGVIIQNDGN 711 F+G+P K RIG V YE S+ + +L I ++ GH+ DL T+ + DG Sbjct 634 WFWGRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDLTTDSVGSKYGVDEDGG 693 Query 712 MLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILI 771 + Y TIKRC DCG Q CPRCGS D+ V+ +R+LA EVDEI+I Sbjct 694 --GYRAYYSTIKRCLDCGAQHTS--SSPFCPRCGSPRQVDSKSVVEILRKLASEVDEIVI 749 Query 772 ATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVR 831 ATDPD EGEKIAWD+ + PY PN++R FHEVT A+++A++ V + + AQ VR Sbjct 750 ATDPDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRSGESVEKSLIEAQKVR 809 Query 832 RIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGL 891 RI DRWIGF LS L+ F L AGRVQTPVLGWI++RY+E+ ++ Y + L +G Sbjct 810 RIVDRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGG 869 Query 892 QFTVEIGKDGKEVEP---PEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPET 948 + T ++ EVE E++ V + + +E NP PPYTTD L DAS L LSA Sbjct 870 R-TSYFTQNRLEVENLKRVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLA 928 Query 949 MRLAQDLFEAGL 960 M++AQDLFE+GL Sbjct 929 MKIAQDLFESGL 940 Range 2: 942 to 1181 Score:194 bits(492), Expect:1e-48, Method:Compositional matrix adjust., Identities:107/241(44%), Positives:145/241(60%), Gaps:2/241(0%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQLV 1510 TYHRTDST VS TG+++A EY+ E +PR WGE G HEAIRP RPID L + V Sbjct 942 TYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAV 1001 Query 1511 RDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEIIE 1570 G I++P LTR H R+YDMIFRRF+ SQMK A L + A + AG G V + Sbjct 1002 LSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVFNHAG-VARVR 1060 Query 1571 DGWTKLRSPNFRQ-LPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTY 1629 G+ + P + L RL G ++ V + K+ +LY GDI+ MM+E IGRPSTY Sbjct 1061 GGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMREHGIGRPSTY 1120 Query 1630 AKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEE 1689 AK ++ + YV E++ + L+PT G+ +Y YL +K LVS + TR LEE ++ +E+ Sbjct 1121 AKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEALERVEK 1180 Query 1690 G 1690 G Sbjct 1181 G 1181 >RecName: Full=Reverse gyrase; Short=TtRG [Caldanaerobacter subterraneus subsp. tengcongensis MB4] Sequence ID: Q8R979.1 Length: 1117 Range 1: 7 to 912 Score:525 bits(1351), Expect:2e-161, Method:Compositional matrix adjust., Identities:365/1020(36%), Positives:540/1020(52%), Gaps:139/1020(13%) Query 3 AIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWER 62 A Y C NC G +D R PC+ CL P V LK+ +LK +E+ Sbjct 7 AKYYHSCINCGGINTDTRNEKGLPCEVCL--PFEDGD-------VLKGLKLNNSLKGYEK 57 Query 63 IYSLEKNLREIEGFF-----ERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGA 117 ++L + +E E FF ++ TG+ QR W KRLL +SF+++APTG+GK+TFG Sbjct 58 YWNLNQQYKEFEEFFFSKINKKPTGY-----QRFWAKRLLLSKSFTLVAPTGVGKTTFGL 112 Query 118 FMAVWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLA 177 A+W A KG K +V PT LV Q +++ + + ++N+ +Y +L+KKE+E+ Sbjct 113 ISALWIAKKGGKVALVFPTVSLVEQAAKRLIEFS-KEDEDVNILFYTSSLKKKEREKFEK 171 Query 178 KIQGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDD 237 +YDILV S+Q+++++ E L + FD +FVDDVDA LK+SKNID L ++G + Sbjct 172 NFSEGNYDILVISSQFISKR-KEQLSQKVFDLVFVDDVDAVLKSSKNIDTLLNMIGISQK 230 Query 238 IIGKAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIAS 297 I + +K G D+ +IEE + G +I++S Sbjct 231 AIDSTLDNLK---------KGNNSDK---------------IQIEE---KAPKGRLIVSS 263 Query 298 ATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELL---TMLGKGG 354 AT +G + L+RELLGFE+G ++ RN+ + +K + +E+LL +L G Sbjct 264 ATAKPKGIKPLLFRELLGFEIGRFTTSARNITNVRIK-----EKSLEKLLYIINLLKDGI 318 Query 355 IIFTPIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLV 414 ++F P ++ +E+ NYL E G ++ +K+ E+F+ G L G +YYG LV Sbjct 319 LLFVPTEEE---GKEIANYLEEHGVKLGKTWEDFEKSFEKFKEGSLQLLCGIYSYYGKLV 375 Query 415 RGLDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARL 474 RG+DLP I++AVF G P F+FS LE Sbjct 376 RGIDLPLRIKFAVFWGTPSFKFSTKLE--------------------------------- 402 Query 475 RRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALH---DEEVLKKL 531 N P+F L + + E P + + + R E LRK++ E +KL Sbjct 403 -----NAPRFILERNFQDYLENNP---KLKAYFKDLQRLSTEKLRKSVEKYISPETWEKL 454 Query 532 AEDPFVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVR 591 + F + ++ K I IPDV TYIQA+GRTSR+F +TKG+S+L +++ +F L Sbjct 455 IQKNFPTTKFDKEKNLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFEEDDSLFELLKA 514 Query 592 QMRWRFQEFKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPN 651 ++ + +E E L +K+ +E R+ + + KD+ KS ++IVESP Sbjct 515 RLLYLTEEEWTEEGEIEHL---VKEAEETRKAI------STDSSSKDM-KSRMIIVESPT 564 Query 652 KARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGN 711 KA+TI+ F + S R G L+ +E +L + AS GH++DL T G HGV I NDG Sbjct 565 KAQTISKFLEKSSTRRYGSLMVHESITQEGILLLTASKGHLYDLETKTGLHGVEI-NDG- 622 Query 712 MLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILI 771 +FIP Y++IKRC CG QF D + CP C S + D ++A+R++A EVDE++I Sbjct 623 --RFIPYYNSIKRCSSCGAQFTD--ELPRCPYCNSDKIDDKKKILEALRDIAMEVDEVII 678 Query 772 ATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVR 831 ATDPD EGEKI WDI + P N++RIE HE+T+ KAI+ R+ + V +QIVR Sbjct 679 ATDPDVEGEKIGWDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRNCDVNLVKSQIVR 738 Query 832 RIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGL 891 RIEDRW+GFELS LQ+ F+N NLSAGRVQ+ VLGWI+E+ E S+S+ TL+NG Sbjct 739 RIEDRWVGFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIEHSKSKKTVTQFTLDNGF 798 Query 892 QFTVEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRL 951 +F V DGK + V VE VE +E+ +P PP+ T ++L AS KL + M + Sbjct 799 KFEV----DGKIDV--DEVEVEIVEEKEQALSPLPPFNTPSLLTAASQQFKLPVQQIMEI 852 Query 952 AQDLFEAGLCV---TPDTLVSLSD-----------GRIMEIKEAVEGSEGNLLAVNGLKP 997 Q LFE G T T +S + G+I + E G EG A+ +KP Sbjct 853 LQTLFELGFITYHRTDSTRISSTGQKIARSYLEKIGKITLLSEREWGKEGAHEAIRPVKP 912 Range 2: 863 to 1110 Score:172 bits(436), Expect:6e-42, Method:Compositional matrix adjust., Identities:101/256(39%), Positives:152/256(59%), Gaps:9/256(3%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGE-EYFKPRHWGEEGTHEAIRPTRPIDTGRLMQL 1509 TYHRTDST +S+TG ++A+ Y+ +++G+ R WG+EG HEAIRP +PI L + Sbjct 863 TYHRTDSTRISSTGQKIARSYL-EKIGKITLLSEREWGKEGAHEAIRPVKPISPEELSEF 921 Query 1510 VRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEII 1569 + + I L+ H ++Y +IF RFM SQM + ++ ++ +I G + E E V++ Sbjct 922 ITEKIAAY---LSPMHIKVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQ 978 Query 1570 EDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTY 1629 E+GW + +P P E K VV + + V L++Q +I M++R IGRPSTY Sbjct 979 EEGWN-IFNPITVYTPF--EEKKYSVVSKRTYTTHTVPLFTQASLIEEMQKRNIGRPSTY 1035 Query 1630 AKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEE 1689 AKIV L +R Y+ E K+L T G KVY YL +Y + ++EE TR LE+ M+ +E Sbjct 1036 AKIVDILFKRKYIIEDV-YKRLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVET 1094 Query 1690 GKLDYLKVLYDLYNEI 1705 G+ DY VL +LY E+ Sbjct 1095 GEKDYQSVLKNLYEEL 1110 >RecName: Full=Reverse gyrase [Thermotoga maritima MSB8] Sequence ID: O51934.1 Length: 1104 Range 1: 7 to 906 Score:516 bits(1328), Expect:3e-158, Method:Compositional matrix adjust., Identities:365/1014(36%), Positives:550/1014(54%), Gaps:128/1014(12%) Query 5 YREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEWERIY 64 Y C NC G +DER PC+ CL E +D Y AL + TLKE+ + Sbjct 7 YHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIY--------RALLERKTLKEYRFYH 58 Query 65 SLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHA 124 + FF++ G QR W KR+++G+SF+++APTG+GK+TFG A+W A Sbjct 59 EFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLA 118 Query 125 TKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQGEDY 184 KGKKS +V PT LV QT+ ++Q +A+ ++ + ++ +++K+EKE+ + +DY Sbjct 119 RKGKKSALVFPTVTLVKQTLERLQKLADE---KVKIFGFYSSMKKEEKEKFEKSFEEDDY 175 Query 185 DILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIGKAWE 244 ILV S Q+++ K E L + FDF+FVDDVDA LKAS+NID L ++G ++II KA+ Sbjct 176 HILVFSTQFVS-KNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFS 234 Query 245 IIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATGSARG 304 IK G+ +R + LK GI++++SAT RG Sbjct 235 TIK---------QGKIYERPKNLKP---------------------GILVVSSATAKPRG 264 Query 305 DRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTPIDQGL 364 R L+R+LL F VG S RN+ ++++ + K + ELL + G +IF ++ Sbjct 265 IRPLLFRDLLNFTVGRLVSVARNI--THVRISSRSKEKLVELLEIFRDGILIFAQTEEE- 321 Query 365 GYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLPHLIR 424 +EL YL+ F V S+ +K E F+ G+ + L+G YYG L RG+DLP I+ Sbjct 322 --GKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIK 379 Query 425 YAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRNIPQF 484 Y +F G P RFS++L++ + +L E M + ++ E+L R I + Sbjct 380 YVIFWGTPSMRFSLELDKAPRFVLARVLKE-MGLIKAQENPDVEEL--------RKIAKE 430 Query 485 ELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPFVSLTEEEG 544 L + EF V +FR +V + DE++ Sbjct 431 HL------------TQKEFVEKVKEMFRGVV------VKDEDL----------------- 455 Query 545 KWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVP 604 + IPDV TYIQA+GR+SR+ G + KG+SV+ ++E++F L + E +++ Sbjct 456 --ELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESL-KTRLLLIAEEEIIE 512 Query 605 FEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPS 664 E + E++ ++ + ++ D +S L+IVESP KA T++ F G+ S Sbjct 513 EAEANWKELVHEV--------EESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRAS 564 Query 665 KTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVIIQNDGNMLKFIPVYDTIKR 724 + +++ +E G ++ A+ GH++DLVT G HGV +N KF+PVY+++KR Sbjct 565 SRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENG----KFVPVYNSLKR 620 Query 725 CRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGEKIAW 784 CRDCG+QF E + CP C S N+ D + ++A+RE++ E DEIL+ATDPD EGEKI+W Sbjct 621 CRDCGYQFT--EDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISW 678 Query 785 DIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGFELSQ 844 D+ L P T +++RIE HE+TR KA + R V+ V AQIVRR++DRWIGFELS Sbjct 679 DVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSG 738 Query 845 ELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQFTVEIGKDGKEV 904 +LQ+ F NLSAGRVQ+ VLGWI+ER +E+ +SE F L LENG+ VE GK +V Sbjct 739 KLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVE-GKIADDV 797 Query 905 EPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCV-- 962 VTV +++ E+E NP PPYTT + L + S L+L E M + QDLFE G Sbjct 798 -----VTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYH 852 Query 963 -TPDTLVSLSDGRIMEI------KEAV-----EGSEGNLLAVNGLKPKEAKALK 1004 T T +SL + KE + +EG A+ +KP +A+ L+ Sbjct 853 RTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELE 906 Range 2: 739 to 1097 Score:186 bits(473), Expect:2e-46, Method:Compositional matrix adjust., Identities:135/372(36%), Positives:191/372(51%), Gaps:33/372(8%) Query 1354 KLKFRNGVKNRILKETGIDIWNWLKRLEGEIPRSKLAKVLEYAEEGPEKEFLKSLVEAGV 1413 KL+ R G N + W+ E E +S+ L E G E + + V Sbjct 739 KLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVV 798 Query 1414 TWVKVKEVEEEHYTGKLYDFTTTTE----------------NFLSNGAVSHNCTYHRTDS 1457 T V+++E EEE L +TT++ + L + TYHRTDS Sbjct 799 TVVELQEAEEEK--NPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDS 856 Query 1458 THVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQLVRDGIIQL 1517 T +S G VA+ Y+ + E+ F R W EG HEAIRP +PID L +++ +G+I Sbjct 857 TRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIA- 915 Query 1518 PKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEIIEDGWTKL- 1576 +LT+ H R+Y++IF RF+ SQ A K+ + +D + +E VEI+ DGW Sbjct 916 --DLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFV 973 Query 1577 ---RSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTYAKIV 1633 SP F E K+ E K +K V L++Q I+ MK+R IGRPSTYAKIV Sbjct 974 PLTVSPRF-------EHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIV 1026 Query 1634 QTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEEGKLD 1693 + L +R YV+E + K++ PT G+ VY YL +Y+ V+EE TR LEE MD +E G+ D Sbjct 1027 EVLFRRGYVYEDK-YKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEED 1085 Query 1694 YLKVLYDLYNEI 1705 Y L LY EI Sbjct 1086 YQATLRLLYEEI 1097 >RecName: Full=Reverse gyrase subunit B; AltName: Full=Helicase-like/topoisomerase subunit of reverse gyrase [Methanopyrus kandleri AV19] Sequence ID: F1SVH1.1 Length: 1221 Range 1: 60 to 994 Score:509 bits(1312), Expect:1e-154, Method:Compositional matrix adjust., Identities:351/952(37%), Positives:536/952(56%), Gaps:109/952(11%) Query 3 AIYREMCPNCLGRISDERLINK-NPCDECLDEPVHADSYFELITAVRNALKVKGT----- 56 AI+ C C G S RL ++ C+ CL PV ++ E++ R G Sbjct 60 AIFGSSCVLCGGDCSSVRLTSRIGICERCL--PVDTETLREVLKEARKRHGYVGEALLMF 117 Query 57 ----------LKEWERIYSLEKNLREI-EGFFERATGFTFWSAQRTWVKRLLKGRSFSII 105 ++E+ R Y + EI + F+RATGF +SAQR W +RL+KG SFSI+ Sbjct 118 ILVERYSPDRVEEFFRRYVWPELFTEIVDRVFDRATGFRLYSAQRVWTRRLVKGCSFSIL 177 Query 106 APTGMGKSTFGAFMAVWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHG 165 APTG GK+++G+ +A G++ Y +VPTT LV Q +I+ A A +++++ YH Sbjct 178 APTGTGKTSWGSLVAAVFGHAGRRVYYLVPTTTLVRQVENRIKGFARDAELDVDVVAYHA 237 Query 166 NLRKKEKEEMLAKIQGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKAS-KN 224 + + K E L +I D+D+L+T+AQ++ + ++ L+ +FD I VDDVDA ++ + +N Sbjct 238 AMPTQAKREALERISSGDFDVLITTAQFLVHRVED-LEKLNFDLILVDDVDAIIRGTGRN 296 Query 225 IDRSLYLLGFNDDIIGKAWEIIKLKKQ---MSKYL-------NGRAQDREEKLKELNSEI 274 +DR L + G + I A+ + L+++ + +L + RA+ E+L+E+ EI Sbjct 297 VDRVLRVAGLEQEEIDSAYRLATLRRRYYSLRDWLRSLEDRGDKRAERVREELREVEREI 356 Query 275 SRLQREIEEFKRENKIGIMIIASATGSAR-GDRIKLYRELLGFEVGSGRSALRNVVDSYL 333 L+ ++ K+E + ++ SATG+A R+ + REL FEVG+G LRN+ D + Sbjct 357 EELEELLKRVKKERDLARIVFMSATGAAAPSRRLAVVRELFDFEVGAGGEGLRNIQDIAV 416 Query 334 --KPTRDIKGHVEELLTMLG-KGGIIFTPI-----DQGLGYAEELVNYLRERGFRVELV- 384 +P+ + VE ++ G KGG+IF P + EEL +LR G + Sbjct 417 ISEPSPE---AVERIVRKAGVKGGLIFVPQRLPGEKKAREIVEELAEHLRSSGIEARAIH 473 Query 385 ----SSKNKKAIERFENGEADYLVGSATYYGSLVRGLDLPHLIRYAVFTGVPKFRFSI-- 438 + + ++AI+ F G+ D LV A+ YG +VRGLDLP RYAVF GVP+ R + Sbjct 474 AGTPAEEREEAIDGFSEGDVDVLVAVASPYGVIVRGLDLPQAARYAVFYGVPRQRIRLTP 533 Query 439 ---DLERPT-IYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLIRN-------------- 480 DL+ PT + AL L+ ++D R + E + RL R+IR Sbjct 534 REEDLKDPTYVASALSNLARLLD--DRRARSRLEGVAGRLWRIIRRGTWIRERLEEAVEP 591 Query 481 IPQFELLKIE----EALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPF 536 + L+K+ E +AE L ++ HV E V L + L D + +K LAE+ Sbjct 592 LSLNTLMKLAKRDPEDIAEQLDVDRWLARHV-QTLAEGVRELTRLLGDPDRVKALAEEAT 650 Query 537 VSLTEEEG-KWYIEIPDVRTYIQATGRTSRLFAGGITKGLS-VLIVDNE---KVFNGLVR 591 EEG + Y+E+PD+RTYIQA+GR SRLFAGG+T GLS VL ++E + NGL+R Sbjct 651 TVAVYEEGEEAYLEVPDLRTYIQASGRVSRLFAGGVTFGLSFVLCPEDERELRTLNGLIR 710 Query 592 QMRWRF-QEF------KMVPFEEL----------DLDEILKQIDEDREKVRLVMEGKISA 634 +M + + EF K + +E+ +L+E+++++DEDRE+VR V+ G++ Sbjct 711 RMSYTYGSEFEWRSYPKSLDMKEIGLELKEISDEELEELVRKVDEDRERVRKVLAGELKP 770 Query 635 -KVKDLVKSALMIVESPNKARTIANFFGQ-PSKTRIGDLVAYEVSIGNMMLTILASGGHM 692 + L +SALMIVESPNKAR IA+ F Q PS+ R+ VAYE + + LT++A+ GH+ Sbjct 771 EETGRLARSALMIVESPNKARMIASLFSQRPSRRRLNGGVAYEAAADGLHLTVVATQGHV 830 Query 693 FDLVTNEGYHGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDA 752 DLV G HGV+ ++ +++P+YD + RC +CG Q V E+ CP CG V Sbjct 831 ADLVEEPGVHGVLRIDE----RWVPMYDVLGRCSECGEQVVGSEE---CPNCGG-EVELK 882 Query 753 LDNVKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMK 812 ++++RELA E D ILI TDPDTEGEKI WD+ N L T + R EFHEVTR I + Sbjct 883 TPLLESIRELASEADVILIGTDPDTEGEKIGWDVFNYLGWTTAQVYRTEFHEVTRRGISE 942 Query 813 AIQEA--RDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQT 862 A++E ++V+ GRV+AQI+RR+ DRWIGF LSQ+L VF++ + G + + Sbjct 943 ALKEESWKNVDAGRVSAQILRRVADRWIGFSLSQDLWDVFKHLEIKLGELPS 994 Range 2: 1096 to 1122 Score:47.0 bits(110), Expect:0.002, Method:Compositional matrix adjust., Identities:20/27(74%), Positives:24/27(88%), Gaps:0/27(0%) Query 855 LSAGRVQTPVLGWIIERYKEFSESETY 881 LSAGRVQTPVLGWII+R +E+ E+E Y Sbjct 1096 LSAGRVQTPVLGWIIDRAREYRETEFY 1122 >RecName: Full=Reverse gyrase 2; Short=RG2; AltName: Full=TopR2 [Saccharolobus solfataricus P2] Sequence ID: Q97ZF5.1 Length: 1166 Range 1: 2 to 900 Score:507 bits(1305), Expect:3e-154, Method:Compositional matrix adjust., Identities:329/978(34%), Positives:525/978(53%), Gaps:97/978(9%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECL------DEPVHADSYFELITAVRNALKVK 54 + +Y+ CPNC G IS +RL+N PC+ CL D+ H L + N K+K Sbjct 2 INVMYKNSCPNCGGDISGDRLLNGLPCEACLPYINGIDDVDHISKVKTLYNILLNNDKIK 61 Query 55 GTLKEWERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKST 114 + I + E + +F TG+ WS Q+ W++RL +SF++ APTG+GK+T Sbjct 62 NYWNLYYNITTFETVFK----YFRDKTGYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTT 117 Query 115 FGAFMAVWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEE 174 + + G+ +VPT L+ Q +++ E+ G +++ G + +K+ Sbjct 118 T---LMTYSVFIGQDVVYIVPTKSLMEQVCKRL----EKLGAQVSC----GKIDQKK--- 163 Query 175 MLAKIQGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGF 234 + V + ++ + D ++ + +F+ +DD DA +K+ K DR + LLG Sbjct 164 -----------VSVITISYLNKNADSIVSLKP-NFVVIDDADAVIKSGKTTDRLVSLLGI 211 Query 235 NDDIIGKAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMI 294 D+ A ++I+L+ + + N ++ +EK++EL + +I EFK +KI ++ Sbjct 212 PKDVYESAIQLIRLRNKYY-FSNEYTEEVKEKIREL-------ELKIAEFK--DKISQLV 261 Query 295 IASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGG 354 IASAT +G + K R L GFE S + RN++D+Y + D+ ++ LG GG Sbjct 262 IASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDAYTE-NLDL-----SIVKELGSGG 315 Query 355 IIFTPIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLV 414 +I + G E+ Y+ + GF +L S +K ++ F G+ D LVGSA+YYG V Sbjct 316 LILVSKEYGRSKLNEIKKYVEDLGFNAKLAIS-GRKFLDDFSQGKVDILVGSASYYGVAV 374 Query 415 RGLDLPHLIRYAVFTGVPKFRFSI--DLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHA 472 RG+D P ++Y ++ GVPK R + L P +G L I DF KL Sbjct 375 RGIDEPKRLKYVIYYGVPKIRAKLFDALSNPFTLLRVGKLIGI-DF---------SKLQN 424 Query 473 RLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHD---EEVLK 529 ++ LI N + +LLK E + + H L R+ + + + D E+V Sbjct 425 KI--LILNPSEVQLLKFSIIKGESI------NYHKLEQLRQELLYYMSLVKDKLKEKVED 476 Query 530 KLAEDPFVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGL 589 L D FV +T++ G +YI PD+ TY+Q +GR SRL+ GG+T G S+++VD+ +F L Sbjct 477 TLISDSFV-ITKQNGNYYIVYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDRHIFEIL 535 Query 590 VRQMRWRFQEFKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVES 649 ++M+ F +L EI ++++ R++ EG +V + + L+IVES Sbjct 536 EKKMQKLFPNTTFTSLSNTNLSEIKIKLEDSRKE-----EGN---RVHFNISTGLLIVES 587 Query 650 PNKARTIANFFGQPSKTRIGDLVAYEVSI--GNMM--LTILASGGHMFDLVTNE-GYHGV 704 P KA+TIA F +PS + YE I GN + L I+AS GH+ DL + GY+G+ Sbjct 588 PTKAKTIAKMFSRPSVRIRNKVPVYETIIVDGNQIYVLDIVASKGHIVDLTLEDIGYYGI 647 Query 705 IIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQ 764 +++DG + P YD IK+C DC F K CP CGS N++ A + +RELA Sbjct 648 KVEDDGTIK---PYYDLIKKCLDCNKIFSSASDK--CPYCGSANLQSAQTTINLLRELAL 702 Query 765 EVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGR 824 VD++ IA+DPDTEGEKIA+D+ + LSPY N+ R+ +HE+T+ AI++A++ + +N Sbjct 703 SVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRVVYHEITKKAILEALRNPKKINTNL 762 Query 825 VNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSES--ETYF 882 V +QIVRRIEDRWIGF LS L+ F N AGRVQTPVLGWI+ + ++ + + Sbjct 763 VMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVNKTIKYKSAMGHVVY 822 Query 883 LGLTLENGLQFTVEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLK 942 + + + ++ E K + + + +EK+ E+ +P PP+TTD +L +A+ K Sbjct 823 IDIAGYSIKKYFSEKRKVEEYINNLQVARIEKISEEKILLSPLPPFTTDTLLIEANMKYK 882 Query 943 LSAPETMRLAQDLFEAGL 960 L A M++AQDLFEAGL Sbjct 883 LPANLVMKIAQDLFEAGL 900 Range 2: 902 to 1153 Score:177 bits(450), Expect:1e-43, Method:Compositional matrix adjust., Identities:99/257(39%), Positives:147/257(57%), Gaps:7/257(2%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHW--GEEGTHEAIRPTRPIDTGRLMQ 1508 TYHRTDSTH+S+ GIE+AKEY+ ++ + F PR W EEG HEAIRPTR ID L+Q Sbjct 902 TYHRTDSTHISSVGIEIAKEYLQKQALIKEFVPRSWESSEEGAHEAIRPTRAIDVNELIQ 961 Query 1509 LVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEI 1568 + + + ++ H +YD+IF+RF+ SQM A R +I G + Sbjct 962 EIEENPYKYSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLIKLGKDDNVDVELLSN 1021 Query 1569 IEDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPST 1628 E G+ K+ LP + K+ + K QL S D+I++MK + IGRPST Sbjct 1022 AEGGFIKVYPVKVYNLPVGEIQPKVNIT-----KGSSEQLLSYSDVISLMKSKGIGRPST 1076 Query 1629 YAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIE 1688 YAK ++ L++ Y+ ++ + L+ T++GI VY +L +K+ DLVSE T L K+D I Sbjct 1077 YAKTIENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLVSESTTSRLMTKLDDIA 1136 Query 1689 EGKLDYLKVLYDLYNEI 1705 KL+ VL ++++EI Sbjct 1137 LSKLNASTVLLEIFSEI 1153 >RecName: Full=Reverse gyrase [Saccharolobus shibatae B12] Sequence ID: P74759.1 Length: 1166 Range 1: 2 to 900 Score:498 bits(1281), Expect:6e-151, Method:Compositional matrix adjust., Identities:321/976(33%), Positives:528/976(54%), Gaps:93/976(9%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLD--EPVHADSYFELITAVRNALKVKGTLK 58 + +Y+ CPNC G IS +RL+N PC+ CL + + + A+ N L +K Sbjct 2 INVMYKNSCPNCGGDISADRLLNGLPCETCLPYINGIDGIDHISKVKALYNILLDNDKIK 61 Query 59 EWERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAF 118 + +Y + +F+ TG+ WS Q+ W++RL+ +SF++ APTG+GK+T Sbjct 62 NYWNLYYNITTFETVFKYFKDKTGYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTT--- 118 Query 119 MAVWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAK 178 + + G+ +VPT L+ Q +++ E+ G +++ G + +++ Sbjct 119 LMTYSVFIGQDVVYIVPTKSLMEQVCKRL----EKLGAQVSC----GKVDQRK------- 163 Query 179 IQGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDI 238 + V + ++ + D + + +F+ +DD DA +K+ K DR + LLG +D+ Sbjct 164 -------VSVITISYLNKNADSITSYKP-NFVAIDDADAVIKSGKTTDRLVSLLGIPNDV 215 Query 239 IGKAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASA 298 A ++I+L+ + + N ++ +EK++EL + +I EFK +KI ++IASA Sbjct 216 YESAIQLIRLRNKYY-FSNEFTEEIKEKIREL-------ELKIAEFK--DKISQLVIASA 265 Query 299 TGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFT 358 T +G + K R L GFE S + RN++D+Y D+ ++ LG GG+I Sbjct 266 TIRPKGIKQKALRLLTGFEPSSIQLYARNIIDTY-TDNLDL-----SIIKELGSGGLILV 319 Query 359 PIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLD 418 + G E+ Y+ + GF +L S +K ++ F G+ D LVGSA+YYG VRG+D Sbjct 320 SKEYGRSRLNEIKKYVEDLGFNAKLAIS-GRKFLDDFSQGKVDILVGSASYYGVAVRGID 378 Query 419 LPHLIRYAVFTGVPKFRFSI--DLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRR 476 P ++Y ++ GVPK + + L P +G + + +L ++ Sbjct 379 EPKRLKYVIYYGVPKIKAKLFDALSNPFTLLRVGKMIGV----------NFSELQNKI-- 426 Query 477 LIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEEVLKKLAEDPF 536 L+ + + +LLK E + + L R+ + + + D+ LK++ E+ Sbjct 427 LVLSPSEAQLLKFSIIKGETINYQK------LEQLRQELLYYISLVKDK--LKEIGEETL 478 Query 537 VS----LTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQ 592 +S + ++ +YI PD+ TY+Q +GR SRL+ GG+T G S+++VD++ +F L ++ Sbjct 479 ISDNFVIAKQNTNYYIIYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDKHIFEILKKK 538 Query 593 MRWRFQEFKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNK 652 M+ F ++L EI +++E R++ EG +V + + L+IVESP K Sbjct 539 MQKLFPNTNFTSLSNINLSEIKTKLEESRKE-----EGN---RVHFNISTGLLIVESPTK 590 Query 653 ARTIANFFGQPSKTRIGDLVAYEVSI--GNMM--LTILASGGHMFDLVTNE-GYHGVIIQ 707 A+TIA F +PS I + YE I GN + L ++AS GH+ DL + GY+G+ I+ Sbjct 591 AKTIAKMFSRPSVRVINKVPVYETIIVDGNQIYVLDVVASKGHIVDLTLEDIGYYGIKIE 650 Query 708 NDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVD 767 G ++K P YD IK+C DC F K CP CGSTNV+ A + +RELA VD Sbjct 651 YSG-IIK--PYYDLIKKCLDCNKTFSIASDK--CPYCGSTNVQTAQTTINLLRELALSVD 705 Query 768 EILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNA 827 ++ IA+DPDTEGEKIA+D+ + LSPY NI RI +HE+T+ AI++A++ +N V + Sbjct 706 KVFIASDPDTEGEKIAYDLASFLSPYNSNIYRITYHEITKKAILEALRNPMKINTNLVMS 765 Query 828 QIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTL 887 QIVRRIEDRWIGF LS L+ F N AGRVQTPVLGWI+++ ++ + Y + + + Sbjct 766 QIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVDKTIKYKSAMGYVVYIDI 825 Query 888 EN---GLQFTVEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLS 944 + F+ E K + + + V +EK+ E+ +P PP+TTD +L +A+ KL Sbjct 826 AGYPIKMHFS-ERKKMEEYINNLQVVKIEKIFEEKILLSPLPPFTTDTLLIEANMKYKLP 884 Query 945 APETMRLAQDLFEAGL 960 A M++AQDLFEAGL Sbjct 885 ANLVMKIAQDLFEAGL 900 Range 2: 902 to 1153 Score:175 bits(443), Expect:1e-42, Method:Compositional matrix adjust., Identities:99/257(39%), Positives:144/257(56%), Gaps:7/257(2%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHW--GEEGTHEAIRPTRPIDTGRLMQ 1508 TYHRTDSTH+S+ GIE+AKEY+ ++ + F PR W EEG HEAIRPTR ID L+Q Sbjct 902 TYHRTDSTHISSVGIEIAKEYLQKQGLIKDFVPRSWESSEEGAHEAIRPTRAIDVNELIQ 961 Query 1509 LVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEI 1568 + + + ++ H+ +YD+IFRRFM SQM A R +I + Sbjct 962 EIEENPYKYSIRFSKLHFLIYDLIFRRFMASQMSHAVGTKSRYLIKLNKNDNINAELLSN 1021 Query 1569 IEDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPST 1628 E G+ K+ LP + K+ K QL S D+I++MK + IGRPST Sbjct 1022 AEGGFIKVYPVKVYNLPLGEVKPKVNT-----GKGSSEQLLSYSDVISLMKSKGIGRPST 1076 Query 1629 YAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIE 1688 YAK ++ L++ Y+ ++ + L+ T++GI Y +L +K+ DLVSE T L K+D I Sbjct 1077 YAKTIENLVRHGYIVSSKRKSYLIATNRGISAYQFLSSKFYDLVSEGTTAKLMSKLDDIA 1136 Query 1689 EGKLDYLKVLYDLYNEI 1705 KL VL ++++EI Sbjct 1137 LSKLSASTVLLEIFSEI 1153 >RecName: Full=Reverse gyrase 1 [Sulfurisphaera tokodaii str. 7] Sequence ID: Q971T7.1 Length: 1156 Range 1: 2 to 892 Score:474 bits(1221), Expect:1e-142, Method:Compositional matrix adjust., Identities:326/980(33%), Positives:512/980(52%), Gaps:109/980(11%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 +K Y CPNC G I DE L+ PC +CL V Y + + L TLK + Sbjct 2 LKVYYTFGCPNCGGPIDDEHLLAGVPCSKCLPGRVENLDY----RVIYDLLVKNSTLKGY 57 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 + + EI F+R G W+ Q+ W+KRL K SFS+ APTG+GK+T + Sbjct 58 AEYFYDNETFEEIVRIFKRVIGNEPWNLQKYWIKRLAKSESFSLSAPTGLGKTTT---LL 114 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQ 180 V+ + VVPT L Q +++ M AK+ Sbjct 115 VYSLFFSNTTLYVVPTNSLKDQICERLR-------------------------NMGAKVS 149 Query 181 GEDYDILVTSAQWMARKFDEVLKGRHFD--------FIFVDDVDAFLKASKNIDRSLYLL 232 D V F+ +L RH+D + VDD D LK+ K + +L Sbjct 150 CND----VKEEYINVATFNRIL--RHYDNYVSLQPKLVIVDDSDMILKSGKTTEVMAKIL 203 Query 233 GFNDDIIGKAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGI 292 G +++I A +I+LK R E KEL ++I L+ +I +K + Sbjct 204 GISEEIFQYAISLIRLK---------RILKFNEDDKELKNKIVELEYKIGSWKPFVQ--- 251 Query 293 MIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGK 352 ++ASAT +G + + R L+GFE + ++ LRN+ D Y + DI+ ++++ Sbjct 252 FLVASATLRPKGIKQQALRTLIGFEPSTIQTYLRNIADLYYQGV-DIEAILDKIS---DN 307 Query 353 GGIIFTPIDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGS 412 GG++ + G EL + +RG+ L S +K + +F G+ DYL+GSA+YYG Sbjct 308 GGLLLVSKEYGREKMLELKEIIEKRGYSTGLAIS-GRKFLNKFTEGKIDYLIGSASYYGV 366 Query 413 LVRGLDLPHLIRYAVFTGVPKFRFSID--LERPTIYRALGLLSEIMDFLSDEDRKQAEKL 470 VRGLD P ++Y +F G+PK R ++ L P++ +G L I D K Sbjct 367 AVRGLDEPKRLKYVIFYGIPKIRLNLTDALNNPSLIVKIGELLNI-------DVKDI--- 416 Query 471 HARLRRLIRNIPQFELLKI----EEALAEGLPIENEFHNHVLGVFRELVEFLRKALHDEE 526 R + L + P+F++L+ +E L+ L + +++ + ++ + L+ + Sbjct 417 --RRKLLFLSPPEFQILRYSLMKDEELSGKL---KDIKVNLINIKEKIWDVLK-----SD 466 Query 527 VLKKLAEDPFVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVF 586 +KKL D F+ +TE GK+Y+ IPD TYIQA+GR+SR+ + G+T G+S+++VDN + Sbjct 467 NIKKLKADTFL-VTENNGKYYVYIPDTVTYIQASGRSSRIISNGLTFGISIVLVDNIDLL 525 Query 587 NGLVRQMRWRFQEFKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMI 646 + L ++++ F E+D+ E LK + +V + KI+ +K+ L+I Sbjct 526 DILSQKLKKIIPNFMFKNINEVDIRE-LKSLAVSSREVSTSQKKKIN------IKTILLI 578 Query 647 VESPNKARTIANFFGQPSKTRIGDLVAYEVSI---GNMMLT-ILASGGHMFDLVT-NEGY 701 VESP KA+TIA FG+PS+ + + YE I +++T I+A+ GH+ DL T N GY Sbjct 579 VESPTKAKTIARLFGRPSRREVHGIPVYETIILVNDEILITNIIATKGHITDLTTENIGY 638 Query 702 HGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRE 761 +GV + N+ +F Y I +C +CG F + CP CGS + + V A+R+ Sbjct 639 YGVEVGNN----EFNAYYSPIYKCYNCGKTFTI--KSNTCPYCGSVFISSSEKVVSALRK 692 Query 762 LAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVN 821 L+ EVDEI IA+DPD EGEKIA+D+ ++SPY NI RI++HE+TR I+ AI +N Sbjct 693 LSTEVDEIYIASDPDQEGEKIAYDVAMLISPYNKNIYRIKYHEITRNGILNAILNKGKIN 752 Query 822 EGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETY 881 V +QIVRRIEDRWIGFELS L+ +F RN +GRVQ PVL WI+ER KE+ ++ + Sbjct 753 MNLVKSQIVRRIEDRWIGFELSLALKSMFYERNHGSGRVQGPVLSWIVERTKEYKKNYGW 812 Query 882 FLGLTL-ENGLQFTVEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTF 940 L + L + ++ I ++ + + + + ++ NP PP+TTD++L DA Sbjct 813 ILYIKLGDYAIKKFFRIKEEANKFIEKLNIKINLISERKEIQNPLPPFTTDSLLMDAYDK 872 Query 941 LKLSAPETMRLAQDLFEAGL 960 L + + M++AQDLFE+GL Sbjct 873 LGIGSQIVMKIAQDLFESGL 892 Range 2: 894 to 1139 Score:177 bits(449), Expect:2e-43, Method:Compositional matrix adjust., Identities:103/255(40%), Positives:147/255(57%), Gaps:9/255(3%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQLV 1510 TYHRTDSTHVS GI +AKEY+ + + F R WG EGTHEAIRPT +DT L++ + Sbjct 894 TYHRTDSTHVSALGISIAKEYLESKNLNDSFSGRSWGNEGTHEAIRPTSSMDTESLIKDI 953 Query 1511 RDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEIIE 1570 D + T+ H R+YD+IFRRF+ SQMK A++ + I K E+E +I Sbjct 954 EDNPNKYFIKFTKYHLRIYDLIFRRFIASQMKPAEVTYSKFEIFINGEKLEVELPTKI-- 1011 Query 1571 DGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTYA 1630 S F + LK + K + L++ +II MKE++IGRPSTYA Sbjct 1012 -------SGGFSIIYPLKTYVVSEKYSTYLTKGSIIPLFTYAEIIKNMKEKEIGRPSTYA 1064 Query 1631 KIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEEG 1690 K + L++ YV E++ + L+ T+KGIK Y +L + DL+SE +T+ L +K+D I G Sbjct 1065 KTISALIRHGYVVESKRKALLIATNKGIKAYEFLSSCCSDLISENRTKLLLQKIDKIANG 1124 Query 1691 KLDYLKVLYDLYNEI 1705 ++ VL DL+ EI Sbjct 1125 DVNVDYVLEDLHKEI 1139 >RecName: Full=Reverse gyrse subunit B; AltName: Full=Helicase-like subunit of reverse gyrase [Nanoarchaeum equitans Kin4-M] Sequence ID: Q74M79.1 Length: 575 Range 1: 1 to 558 Score:455 bits(1171), Expect:2e-142, Method:Compositional matrix adjust., Identities:259/595(44%), Positives:372/595(62%), Gaps:43/595(7%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 MK Y +CPNC GRIS+ERLI PC+ D P + I V LK LK+W Sbjct 1 MKIYYNNVCPNCSGRISNERLIKGLPCEN--DYPYEEGT----IEQVYEYLKENNKLKDW 54 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 IY++EK +E E FF +A WSAQR W R KG SFSIIAPTGMGK+TF A Sbjct 55 ANIYNIEKAKKEFEEFFYKAVNNKPWSAQRAWFIRAYKGYSFSIIAPTGMGKTTFALVNA 114 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIE-INLAYYHGNLRKKEKEEMLAKI 179 ++ KGKK YI+VPT LV Q KI AER G + I +AYY N +KKE +E+ I Sbjct 115 LYWGKKGKKVYIIVPTRTLVKQLYEKINVFAERVGFDNIIVAYYGNNKQKKEAKEL---I 171 Query 180 QGEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDII 239 + + IL+TS Q+++R FD +LK +FD IF DDVD+ +K+SKNIDR LYLLGF++ I Sbjct 172 KDGAFSILITSNQFLSRNFD-LLKNNYFDIIFADDVDSIMKSSKNIDRILYLLGFSETTI 230 Query 240 GKAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASAT 299 KA ++IKLK ++G+ ++ I +++ +++E R+ + GI+I ASAT Sbjct 231 EKAMQLIKLK------ISGKDLEK----------IRKMEEQLKELVRKEQRGILIAASAT 274 Query 300 GSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGKGGIIFTP 359 GS RG R+KL+RELLGFEVG+ ++ +RN++D Y + RD K EL+ LG GG++F P Sbjct 275 GSMRGLRVKLFRELLGFEVGAAKTTIRNIIDVYTE-MRDYKKQTLELIKKLGNGGLVFVP 333 Query 360 IDQGLGYAEELVNYLRERGFRVE-LVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLD 418 D G+ AEE+ YL+E + E S K+ + ++++ N E D LVG A YYG +VRG+D Sbjct 334 TDYGIEKAEEIAQYLKENNIKAEAFYSGKSIELLDKYANKELDVLVGVAHYYGLIVRGID 393 Query 419 LPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRLI 478 LPH+++YA+F G+P+FRFS + I R L L S + D+ +E +K+ + +I Sbjct 394 LPHVVKYAIFVGIPRFRFSAKEKETKIGRILLLASTLSDYADEEFKKKLNTTY----NMI 449 Query 479 RNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLR----KALHDEEVLKKLAED 534 + + L +EEA+ +N+ + L R+ + +LR + ++ E+++KKL E+ Sbjct 450 KRVSTGALKMVEEAIE-----QNKELDGFLEELRKNIIYLRDKSFELINREDIIKKLEEN 504 Query 535 PFVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGL 589 PF++L +G I IPDV+TYIQA+GRTSR++ GGITKGLS+++ DNEK+ L Sbjct 505 PFIALERGDG-INILIPDVKTYIQASGRTSRMYPGGITKGLSIILSDNEKLLRAL 558 >RecName: Full=Reverse gyrase 2 [Sulfolobus acidocaldarius DSM 639] Sequence ID: P0DW67.1 Length: 1153 Range 1: 2 to 891 Score:463 bits(1191), Expect:2e-138, Method:Compositional matrix adjust., Identities:322/974(33%), Positives:513/974(52%), Gaps:98/974(10%) Query 1 MKAIYREMCPNCLGRISDERLINKNPCDECLDEPVHADSYFELITAVRNALKVKGTLKEW 60 +K Y CPNC G IS +RL PC+ CL V I + + L TLK + Sbjct 2 LKVNYLFGCPNCNGSISVDRLHAGIPCETCLPGAVEKLD----IRTIYDLLVKYSTLKGY 57 Query 61 ERIYSLEKNLREIEGFFERATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMA 120 +Y + +I F++ G WS QR W+ +L++G SFS+ APTG+GK+T + Sbjct 58 SELYMDLEMYDDILRLFKKIVGGEPWSLQRYWLNKLVRGESFSLSAPTGVGKTTTLIVYS 117 Query 121 VWHATKGKKSYIVVPTTPLVIQTVRKIQAVAERAGIEINLAYYHGNLRKKEKEEMLAKIQ 180 V+ T S VVPT L Q K++ + G+L K E Sbjct 118 VYSHTT---SLFVVPTKSLRDQICEKLKKI--------------GHLVSCNKPE------ 154 Query 181 GEDYDILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDDIIG 240 ED + V + + + DE ++ + + VDD D LK+ K +R +L ++ Sbjct 155 -ED-KVNVVTFHSINKNIDEFVRIKP-KLLMVDDADMILKSGKTTERIAKVLQIPQEVFD 211 Query 241 KAWEIIKLKKQMSKYLNGRAQDREEKLKELNSEISRLQREIEEFKRENKIGIMIIASATG 300 ++++LK+ + R ++ ++L +++ L+ +I +K + I++SAT Sbjct 212 DTIKMLRLKRML----------RFKEDEDLINQVRELESKILGYKSSVQ---FIVSSATL 258 Query 301 SARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTRDIKGHVEELLTMLGK-GGIIFTP 359 +G + R L+GFE + + RNV+DS+ +V EL+ +G GG+I Sbjct 259 KPKGYKQMALRFLVGFEPSTIQIYNRNVIDSF-----TYSNNVNELVKEIGDVGGLILVS 313 Query 360 IDQGLGYAEELVNYLRERGFRVELVSSKNKKAIERFENGEADYLVGSATYYGSLVRGLDL 419 D G Y +++ + L G+R + + +K +E+F NG+ D+LVGSA+YYG VRG+D Sbjct 314 KDYGKKYVDQITDNLNAEGYRA-MKAISGRKFLEKFSNGDVDFLVGSASYYGVAVRGIDE 372 Query 420 PHLIRYAVFTGVPKFRFSID--LERPTIYRALGLLSEIMDFLSDEDRKQAEKLHARLRRL 477 P ++Y +F GVPK + ++ L P +G E++ E RK RL Sbjct 373 PKRLKYVIFYGVPKTKLPLEDSLNNPLTALKIG---ELLKLDVTEYRK----------RL 419 Query 478 IRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRKALHD---EEVLKKLAED 534 I P EL ++ AL + + N LG E + L+ + D + KL D Sbjct 420 IYLSPA-ELQAVKIALRNKVSL-----NGKLGDLVEDLTKLKDIILDTIKANKIDKLVSD 473 Query 535 PFVSLTEEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMR 594 FV + ++ K YI PD+ TYIQ +GR+SR+ GG+T GLSV++VD+ ++F+ L +++R Sbjct 474 SFV-IKKDTNKHYIFFPDIITYIQGSGRSSRIMNGGLTLGLSVVLVDDLELFDILNKKLR 532 Query 595 WRFQEFKMVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKAR 654 R E + F+EL LDE+ +++++ R +G + K+AL++VESP KAR Sbjct 533 -RIAEVTFMNFDELKLDEVREKLNKSRS------DGSGGRSMN--FKTALLVVESPTKAR 583 Query 655 TIANFFGQPSKTRIGDLVAYEVSI----GNMML--TILASGGHMFDLVTNE-GYHGVIIQ 707 TI+ FG+ + I + YE I N ++ I+AS GH+ DL T E GY+GV I Sbjct 584 TISKIFGRGVRREIYGIPVYETIIIDDHSNTIIYTNIIASKGHLTDLTTEELGYYGVEIN 643 Query 708 NDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVD 767 + ++ + P+Y RC CG ++ CP CGS+ + + V A+R ++ EVD Sbjct 644 DKDIVVNYSPLY----RCMSCGKTIT--KKVSTCPYCGSSMINSSEKIVNAIRLISTEVD 697 Query 768 EILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNA 827 E+ IATDPD EGEKIA+DI +++SPY NI RI ++E+T+ A++ AI+ +NE V A Sbjct 698 EVYIATDPDQEGEKIAYDIYSLISPYNQNIFRISYNEITKTAVLNAIKSKAKINESLVKA 757 Query 828 QIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTL 887 QI RRIEDRWIGFELS L+ + N GRVQ PVL W++ + E+ + Y + + + Sbjct 758 QIARRIEDRWIGFELSSVLRSALNDNNNGTGRVQGPVLKWVVGKTSEYKANIGYVVDINI 817 Query 888 -ENGLQFTVEIGKDGKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAP 946 + ++ + KD + V V K+ +P PP+TTD++L DA + ++++ Sbjct 818 GDYVVRKFFKTKKDAETFISQLNVKVTKIAERTSTIDPLPPFTTDSLLIDAYSKFRINSS 877 Query 947 ETMRLAQDLFEAGL 960 M++AQ+LFEAGL Sbjct 878 LAMKVAQELFEAGL 891 Range 2: 893 to 1138 Score:166 bits(419), Expect:6e-40, Method:Compositional matrix adjust., Identities:97/255(38%), Positives:138/255(54%), Gaps:9/255(3%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQLV 1510 TYHRTDS H+S GI +A+EY+ +++G F R WG EG HEAIRPTR +D L + + Sbjct 893 TYHRTDSIHISPYGISIAREYL-EKIGSNDFVGRSWGNEGAHEAIRPTRSMDVEELRKEI 951 Query 1511 RDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEIIE 1570 + Q T HYRLYD+IFRRF+ SQM +A I+ G+ + Sbjct 952 EENPFQFGIKFTWAHYRLYDLIFRRFIGSQMSSATATYTTYEININ-GELYTVELPTKVH 1010 Query 1571 DGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTYA 1630 G++ + L +++ K V L + D+I +MK+ IGRPSTY Sbjct 1011 GGFSSIYGIRVYNLDESHLTTRIR-------KGSLVSLLTYADVIRLMKDTNIGRPSTYV 1063 Query 1631 KIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEEG 1690 + VQ+L++ YV E++ R L+ T+KG KVY L + D+VSE +T L K+D I Sbjct 1064 RTVQSLIRHGYVVESKKRSFLIATNKGQKVYEILNKYFSDMVSESRTSHLITKIDKINRN 1123 Query 1691 KLDYLKVLYDLYNEI 1705 +L V+ DL NEI Sbjct 1124 ELSAEDVIMDLLNEI 1138 >RecName: Full=Reverse gyrase subunit A; AltName: Full=Topoisomerase-like subunit of reverse gyrase [Nanoarchaeum equitans Kin4-M] Sequence ID: Q74MA4.1 Length: 701 Range 1: 1 to 351 Score:365 bits(938), Expect:2e-108, Method:Compositional matrix adjust., Identities:187/362(52%), Positives:258/362(71%), Gaps:12/362(3%) Query 602 MVPFEELDLDEILKQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFG 661 M+ EE+DLD I K++DE+R+KV +M+G I ++KDL+K L IVESPNKARTIANFFG Sbjct 1 MLRLEEIDLDTIKKELDEERKKVEEIMKGNIPTEIKDLIKMVLFIVESPNKARTIANFFG 60 Query 662 QPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDL-VTNEGYHGVIIQNDGNMLKFIPVYD 720 +PS RIG++ AYE + G +LTI+A+ GH+F+L + EG +GV+ + + ++P++ Sbjct 61 KPSVRRIGNIKAYETTTGKYILTIVATKGHLFELTLKEEGVYGVLKEKE-----YVPIFS 115 Query 721 TIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELAQEVDEILIATDPDTEGE 780 IK+C DCGHQFVD ++ CPRCGS N+ DA D +K +R+LAQE D +LI TDPD EGE Sbjct 116 PIKKCLDCGHQFVDEDK---CPRCGSENIDDASDRIKVLRDLAQEADIVLIGTDPDAEGE 172 Query 781 KIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGF 840 KIA+D+ +++ PY NI R EFHEVTR AI+KA++E RD+N RV AQ+VRRIEDRWIGF Sbjct 173 KIAYDVYSIIRPYNKNIYRAEFHEVTRQAIIKALEEIRDINTNRVKAQLVRRIEDRWIGF 232 Query 841 ELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESETYFLGLTLENGLQFTVEIGKD 900 LSQ L F+ + LSAGRVQTPVLG+II+RY+E+ ++ ++ + + F V D Sbjct 233 ALSQRLWSRFKKKTLSAGRVQTPVLGFIIKRYEEYKKNRAHYYAVKTSD---FEVTFISD 289 Query 901 GKEVEPPEYVTVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGL 960 + + + +EK+E +E E P PPYTTD++L+DA L+LS + M LAQ+LFE GL Sbjct 290 DPLEKYDKTIKIEKIEEKESEKKPLPPYTTDSLLRDAVIELRLSVDKIMALAQNLFEWGL 349 Query 961 CV 962 Sbjct 350 IT 351 Range 2: 350 to 599 Score:244 bits(623), Expect:6e-67, Method:Compositional matrix adjust., Identities:127/257(49%), Positives:173/257(67%), Gaps:7/257(2%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEEGTHEAIRPTRPIDTGRLMQL 1509 TYHRTDSTH+SN GI++A+ YI G+EYF PRHWGEEGTHEAIRPT+PIDT L+++ Sbjct 350 ITYHRTDSTHISNLGIQIAQTYIENTFGKEYFYPRHWGEEGTHEAIRPTKPIDTETLIKM 409 Query 1510 VRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEII 1569 +R+G IQ+ + +T+ H RLYD+IFRRF+ SQMK + + +EG +I Sbjct 410 LREGDIQI-QGITKEHIRLYDLIFRRFIASQMKPFIAIETKFNAVWSNLNTTIEGITDIK 468 Query 1570 EDGWTKLRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGDIIAMMKERKIGRPSTY 1629 E+GW ++ +L +KEG + +V++ K W KV LY+Q D+I +MKE+ IGRPSTY Sbjct 469 ENGWNLIKPI---KLLAIKEG-EYEVIDVKHWIGSKVPLYTQADVIELMKEQNIGRPSTY 524 Query 1630 AKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEE 1689 A IV+ L +RYYV E R L+PT++GIKVY YL ++ LV + T L EKMD IE Sbjct 525 ATIVKKLFERYYVIEKNQR--LIPTERGIKVYQYLTERFGHLVDVKLTADLLEKMDRIEN 582 Query 1690 GKLDYLKVLYDLYNEIL 1706 G+LDY+ VL E++ Sbjct 583 GELDYMDVLRSFKKELI 599 >RecName: Full=Reverse gyrase subunit A; AltName: Full=Topoisomerase-like subunit of reverse gyrase [Methanopyrus kandleri AV19] Sequence ID: Q8TYK7.1 Length: 358 Range 1: 76 to 347 Score:215 bits(547), Expect:2e-60, Method:Compositional matrix adjust., Identities:122/272(45%), Positives:167/272(61%), Gaps:16/272(5%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRHWGEE-----GTHEAIRPTRPIDTG 1504 TYHRTDST VS G VA++YI E + PR W E G HE IRPTRP D Sbjct 76 ITYHRTDSTRVSEEGKRVARDYIRANFDPEDYNPRTWEPEAEHVEGAHECIRPTRPADAE 135 Query 1505 RLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDA---GVGKAE 1561 L +VR+G IQ LT +H RLYD++FRRF+ SQMK AK+L + AV++ GV AE Sbjct 136 ELRTMVREGAIQTTVTLTSHHLRLYDLVFRRFVASQMKPAKVLYQEAVLEVEVKGVPVAE 195 Query 1562 LE--GYVEIIEDGWTK------LRSPNFRQLPRLKEGAKLKVVEAKKWKAPKVQLYSQGD 1613 LE G +EI+E G+TK L + R+ P L+EG +L++ + + + + Y Q + Sbjct 196 LELSGVLEIVEPGFTKVLTEYDLPAYGIRETPELEEGDRLEIGDVEVLERHEEYPYDQSE 255 Query 1614 IIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVS 1673 ++ M+ER +GRPSTYA+IV+ L +R YV+E R+ + PT +G VY YL T Y+ VS Sbjct 256 LVEDMRERGLGRPSTYAQIVEKLFRRGYVYEVPQRRWIFPTTRGEAVYEYLSTHYERFVS 315 Query 1674 EEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEI 1705 EE TR LEE+MD + GK +Y + + LY E+ Sbjct 316 EETTRDLEERMDAVALGKAEYQEEMEKLYLEL 347 Range 2: 37 to 93 Score:46.6 bits(109), Expect:0.001, Method:Compositional matrix adjust., Identities:25/57(44%), Positives:34/57(59%), Gaps:3/57(5%) Query 922 FNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCV---TPDTLVSLSDGRI 975 +P+PP+ T ML+ A+ L+LS+ M+LAQDLFE GL T T VS R+ Sbjct 37 IHPKPPFETGTMLQAATRRLRLSSERVMQLAQDLFEGGLITYHRTDSTRVSEEGKRV 93 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819] Sequence ID: Q9PLZ2.1 Length: 700 Range 1: 1 to 285 Score:129 bits(324), Expect:5e-29, Method:Compositional matrix adjust., Identities:105/338(31%), Positives:159/338(47%), Gaps:72/338(21%) Query 640 VKSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNE 699 +K L+IVESP KA+TI NF G+ YEV +AS GH+ DL + Sbjct 1 MKKNLIIVESPAKAKTIGNFLGKD----------YEV---------IASKGHIRDLPKSS 41 Query 700 GYHGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAM 759 G+ I++D +FIP Y T+ AL VK + Sbjct 42 --FGIKIEDD----EFIPEYRI-------------------------TSDHSAL--VKEL 68 Query 760 RELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARD 819 + A++ E+ +ATD D EGE IA+ I + + RI FHE+T+ AI A++ R Sbjct 69 KSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRK 128 Query 820 VNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---FS 876 +N VNAQ RR+ DR +G++LS L + + R LSAGRVQ+ L I++R KE F Sbjct 129 LNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQ-RGLSAGRVQSAALKIIVDREKEIRAFV 187 Query 877 ESETYFLGLTLENGL-------------QFTVEIGKDGK---EVEPPEYVTVEKVELEEK 920 E + + + + L + T+ K E E ++ +E +E+ Sbjct 188 PLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKER 247 Query 921 EFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 + P PP+ T + + AS L + +TM +AQ L+E Sbjct 248 KIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEG 285 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Halalkalibacterium halodurans C-125] Sequence ID: Q9KA23.1 Length: 690 Range 1: 5 to 332 Score:122 bits(306), Expect:7e-27, Method:Compositional matrix adjust., Identities:115/383(30%), Positives:178/383(46%), Gaps:85/383(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ T+ AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIGKYLGK-------------------KYTVKASMGHVRDLPKSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V I+++ + P Y TI+ G V +K ++ A Sbjct 44 VDIEDE-----YSPRYITIR---------------------GKGPV------LKELKSAA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++V + +A DPD EGE IAW + + L + R+ F+E+T+ AI A + R +N Sbjct 72 KKVKRVYLAADPDREGEAIAWHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMD 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFS--ESETY 881 V+AQ RR+ DR +G+ +S L + + + LSAGRVQ+ + II+R KE E E Y Sbjct 132 LVDAQQARRVLDRLVGYNISPLLWKKVK-KGLSAGRVQSVAVKMIIDREKEIQAFEPEEY 190 Query 882 F--LGLTLENGLQFTVEI-GKDGKEVE--------------PPEYVTVEKVELEEKEFNP 924 + G +G F + G +GK+VE + V+ V+ +E++ NP Sbjct 191 WSIQGTFALDGEPFEAKFYGTNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNP 250 Query 925 QPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSL-----------SDG 973 P+TT ++ ++A+ L A +TM LAQ L+E G+ + + V L SD Sbjct 251 VSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYE-GIDLGKEGTVGLITYMRTDSTRISDT 309 Query 974 RIMEIKEAVEGSEGNLLAVNGLK 996 E KE +E G A NG K Sbjct 310 AKAETKEYIESKFGKEYAQNGTK 332 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus epidermidis RP62A] Sequence ID: Q5HPU2.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus epidermidis ATCC 12228] Sequence ID: Q8CSU3.1 Length: 689 Range 1: 297 to 550 Score:119 bits(298), Expect:6e-26, Method:Compositional matrix adjust., Identities:83/270(31%), Positives:142/270(52%), Gaps:33/270(12%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPR----HWGEEGTHEAIRPTRPIDTGRL 1506 TY RTDST +S + A++YI + GE+Y R G++ HEAIRPT + T Sbjct 297 TYMRTDSTRISTSAKSEAQQYINDKYGEQYVSQRKSSGKQGDQDAHEAIRPTSTMRTPDD 356 Query 1507 MQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVID---------AGV 1557 M+ LTR+ +RLY +I+ RF+ SQM A +++ +D A Sbjct 357 MKAF----------LTRDQHRLYKLIWERFVASQMAPA--ILDTVALDVTQNDIKFRANG 404 Query 1558 GKAELEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKL---KVVEAKKWKAPKVQLYSQGDI 1614 + +G++ + + + +LP+L +G K+ K+ A+ + P + Y++ + Sbjct 405 QTIKFKGFMTLYVEAKDDKENDKENKLPQLDKGDKVTATKIEPAQHFTQPPPR-YTEARL 463 Query 1615 IAMMKERKIGRPSTYAKIVQTLLQRYYV-FETRGRKKLVPTDKGIKVYHYLVTKYKDLVS 1673 + ++E KIGRPSTYA + T+ +R YV E+ K+ +PT+ G VY + + +++ Sbjct 464 VKTLEELKIGRPSTYAPTIDTIQKRNYVKLES---KRFIPTELGEIVYEQVKEYFPEIID 520 Query 1674 EEKTRSLEEKMDLIEEGKLDYLKVLYDLYN 1703 E T ++E +D I EG +++ KV+ D YN Sbjct 521 VEFTVNMETLLDKIAEGDMNWRKVIGDFYN 550 Range 2: 5 to 284 Score:92.0 bits(227), Expect:2e-17, Method:Compositional matrix adjust., Identities:94/334(28%), Positives:150/334(44%), Gaps:73/334(21%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIEKYLGKRYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V +++ + P Y TI+ G V VK +++ A Sbjct 44 VDTEDN-----YEPKYITIR---------------------GKGPV------VKDLKKHA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ +I +A+DPD EGE IAW + +L R+ F+E+T+ A+ + + R + Sbjct 72 KKAKKIFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKDSFKHPRGIEMD 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---FSESET 880 V+AQ RRI DR +G+ +S L + + + LSAGRVQ+ L +I+R E F E Sbjct 132 LVDAQQARRILDRLVGYNISPVLWKKVK-KGLSAGRVQSVALRLVIDRENEIRNFKPEEY 190 Query 881 YFL-GLTLENGLQFTVEI-----------GKDG----KEVEPPEYVTVEKVELEEKEFNP 924 + + G +FT + KD E + + V +EK P Sbjct 191 WSIEGEFRYKKSKFTAKFLHYKNKPYKLNNKDDVQRITEALNGDQFEITNVNRKEKTRYP 250 Query 925 QPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P+TT + ++A+ L A +TM LAQ L+E Sbjct 251 AHPFTTSTLQQEAARKLNFKARKTMMLAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia felis URRWXCal2] Sequence ID: Q4UM42.1 Length: 776 Range 1: 3 to 330 Score:119 bits(298), Expect:8e-26, Method:Compositional matrix adjust., Identities:106/383(28%), Positives:180/383(46%), Gaps:93/383(24%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G K ++AS GH+ DL + +G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKG--- 40 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 ++ ++ +K YD D ++VD A+ + A Sbjct 41 SVLPDENFAMK----YD----ISDKAGKYVD-----------------------AIVKDA 69 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPN-----IKRIEFHEVTRPAIMKAIQEAR 818 ++ D + +ATDPD EGE I+W + V+ KR+ F+E+T+ AI+ A++ R Sbjct 70 KKADAVYLATDPDREGEAISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPR 129 Query 819 DVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---F 875 ++ VNAQ RR D +GF LS L R SAGRVQ+ L I ER E F Sbjct 130 KLDANLVNAQQARRALDYLVGFTLSPLLWRKLPGCK-SAGRVQSVALRLICEREDEIERF 188 Query 876 SESETYFLGLTLENGL-----------------QFTVEIGKDGKEVE---PPEYVTVEKV 915 E + + L ++N +F++ KD K++ + V+K+ Sbjct 189 KSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKDAKDLTEKLKSQNFHVDKI 248 Query 916 ELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTL-------- 967 E ++++ PQPP+ T ++ ++A+ L SA +TM++AQ L+E G+ + +T+ Sbjct 249 EKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYE-GVDIGKETIGLITYMRT 307 Query 968 --VSLSDGRIMEIKEAVEGSEGN 988 V+LS+ I +I++ ++ + G+ Sbjct 308 DGVTLSNDAIADIRKLIDKNYGD 330 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia prowazekii str. Madrid E] Sequence ID: Q9ZDK2.1 Length: 776 Range 1: 3 to 330 Score:119 bits(298), Expect:8e-26, Method:Compositional matrix adjust., Identities:108/383(28%), Positives:178/383(46%), Gaps:93/383(24%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G K ++AS GH+ DL + +G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKGS-- 41 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 + D N F+ YD D ++VD A+ + A Sbjct 42 --VLPDKN---FLMEYDI----SDKAGKYVD-----------------------AIVKEA 69 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPN-----IKRIEFHEVTRPAIMKAIQEAR 818 ++ + + +ATDPD EGE I+W + V+ KR+ F+E+T+ AIM A+ R Sbjct 70 RKAEVVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIMNAVANPR 129 Query 819 DVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---F 875 ++ VNAQ RR D +GF LS L R SAGRVQ+ L I +R E F Sbjct 130 KLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCK-SAGRVQSVALRLICDREDEIERF 188 Query 876 SESETYFLGLTLENG-----------------LQFTVEIGKDGKEVEPP---EYVTVEKV 915 E + + L ++N +F++ K+ K++ + VEK+ Sbjct 189 KSEEYWDISLKMQNSNNDLFTAKLTHVNDQKLKKFSIINEKEAKDLTQKLKLQKFYVEKI 248 Query 916 ELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTL-------- 967 E ++++ PQPP+ T ++ ++A+ L SA +TM++AQ L+E G+ + +T+ Sbjct 249 EKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYE-GVDIGKETIGLITYMRT 307 Query 968 --VSLSDGRIMEIKEAVEGSEGN 988 V+LS+ I +I++ ++ + GN Sbjct 308 DGVTLSNDAIADIRKLIDKNYGN 330 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia typhi str. Wilmington] Sequence ID: Q68X45.1 Length: 779 Range 1: 3 to 330 Score:118 bits(296), Expect:1e-25, Method:Compositional matrix adjust., Identities:107/383(28%), Positives:178/383(46%), Gaps:93/383(24%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G K ++AS GH+ DL + +G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKGS-- 41 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 + D N F YD D ++VD A+ + A Sbjct 42 --VLPDKN---FAMEYDI----SDKASKYVD-----------------------AIVKYA 69 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPN-----IKRIEFHEVTRPAIMKAIQEAR 818 ++ + + +ATDPD EGE I+W + V+ KR+ F+E+T+ AI+ A++ R Sbjct 70 RKAEAVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIIHAVENPR 129 Query 819 DVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---F 875 ++ VNAQ RR D +GF LS L R SAGRVQ+ L I +R E F Sbjct 130 KLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCK-SAGRVQSVALRLICDREDEIERF 188 Query 876 SESETYFLGLTLENG-----------------LQFTVEIGKDGKEVEPP---EYVTVEKV 915 E + + L ++N +F++ K+ K++ + VEK+ Sbjct 189 KAEEYWDISLKMQNSNNELFTAKLTHVNDQKLKKFSIINEKEAKDLTRKLKLQKFYVEKI 248 Query 916 ELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTL-------- 967 E ++++ PQPP+ T ++ ++A+ L SA +TM++AQ L+E G+ + +T+ Sbjct 249 EKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYE-GVDIGKETIGLITYMRT 307 Query 968 --VSLSDGRIMEIKEAVEGSEGN 988 V+LS+ I +I++ ++ + GN Sbjct 308 DGVTLSNDAIADIRKLIDKNYGN 330 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia conorii str. Malish 7] Sequence ID: Q92IH1.1 Length: 776 Range 1: 3 to 330 Score:118 bits(295), Expect:2e-25, Method:Compositional matrix adjust., Identities:106/383(28%), Positives:179/383(46%), Gaps:93/383(24%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G K ++AS GH+ DL + +G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKG--- 40 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 ++ ++ +K YD D ++VD A+ + A Sbjct 41 SVLPDENFAMK----YD----ISDKAGKYVD-----------------------AIVKDA 69 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPN-----IKRIEFHEVTRPAIMKAIQEAR 818 ++ D + +ATDPD EGE I+W + V+ KR+ F+E+T+ AI+ A++ R Sbjct 70 KKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPR 129 Query 819 DVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---F 875 ++ VNAQ RR D +GF LS L R SAGRVQ+ L I ER E F Sbjct 130 KLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCK-SAGRVQSVALRLICEREDEIERF 188 Query 876 SESETYFLGLTLENGL-----------------QFTVEIGKDGKEVE---PPEYVTVEKV 915 E + + L ++N +F++ K+ K++ V+K+ Sbjct 189 KSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSHKFHVDKI 248 Query 916 ELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTL-------- 967 E ++++ PQPP+ T ++ ++A+ L SA +TM++AQ L+E G+ + +T+ Sbjct 249 EKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYE-GVDIGKETIGLITYMRT 307 Query 968 --VSLSDGRIMEIKEAVEGSEGN 988 V+LS+ I +I++ ++ S G+ Sbjct 308 DGVTLSNDAIADIRKLIDKSYGD 330 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Synechococcus elongatus PCC 7942 = FACHB-805] Sequence ID: P34185.2 Length: 883 Range 1: 4 to 341 Score:118 bits(295), Expect:2e-25, Method:Compositional matrix adjust., Identities:116/382(30%), Positives:181/382(47%), Gaps:86/382(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYH- 702 L+IVESP KARTI N+ P R+ E S+G++ + S + + E + Sbjct 4 LVIVESPTKARTIRNYL--PKDYRV------EASMGHVR-DLPQSASDIPTELKGEKWSN 54 Query 703 -GVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRE 761 GV ++N+ F P+Y + P+ D VK +++ Sbjct 55 LGVDVENN-----FAPLY--------------------IVPK-------DKKKIVKTLKD 82 Query 762 LAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVN 821 ++ DE+++ATD D EGE I+W + +L P P KR+ FHE+T+ AI A++ RDV+ Sbjct 83 ALKDADELILATDEDREGESISWHLLQLLQPRVPT-KRMVFHEITQEAIQAALKNCRDVD 141 Query 822 EGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIER---YKEFSES 878 + V+AQ RRI DR +G+ LS L + LSAGRVQ+ + +++R + F + Sbjct 142 QRLVHAQETRRILDRLVGYTLSPLLWKKI-AWGLSAGRVQSVAVRLLVQRERARRAFRQG 200 Query 879 ETYFL--GLTLENGLQFTVEI----------GKD-----GKEVEPPEYVTVEKVE----- 916 + L LT+E G QF ++ G D G+ + + +++ E Sbjct 201 SYWDLKAQLTVEAG-QFEAKLWTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALR 259 Query 917 ------------LEEKEFN--PQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCV 962 LEEK P PP+TT + ++++ L+LSA ETMR+AQ L+E G Sbjct 260 DRLQTQPWQVKSLEEKPTTRKPAPPFTTSTLQQESNRKLRLSARETMRVAQSLYERGFIT 319 Query 963 TPDT-LVSLSDGRIMEIKEAVE 983 T V LS I + VE Sbjct 320 YMRTDSVHLSQQAIEAARSCVE 341 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Aquifex aeolicus VF5] Sequence ID: O66893.1 Length: 540 Range 1: 279 to 532 Score:115 bits(288), Expect:4e-25, Method:Compositional matrix adjust., Identities:93/274(34%), Positives:148/274(54%), Gaps:37/274(13%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYF-KPRHWGE----EGTHEAIRPTRPIDTG 1504 TY RTDS ++ + YI ++ G+EY + R + E +G HE IRPT Sbjct 279 ITYPRTDSYRMNEKKAKEFMNYIEKKYGKEYVGRLRRFREKATAQGAHECIRPTS----- 333 Query 1505 RLMQLVRDGIIQLPKNLTRNHYRL-YDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELE 1563 +R+ I + R RL YD+IFRR + S MK L E+ ++A + + Sbjct 334 -----LREEIPE------REELRLLYDLIFRRTIASLMKEMLLEREKVTVEAITPELKHP 382 Query 1564 GYV-----EIIEDGWTKLRSPNF--RQLPRLKEGAKLKVV----EAKKWKAPKVQLYSQG 1612 Y+ +I+ DGW+++ +LP L EG L +V E +K + P Y++G Sbjct 383 VYLVAKGLKIVFDGWSRVYPSEITEEKLPELYEGDLLDLVKTTLEERKTQPP--PRYTEG 440 Query 1613 DIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLV 1672 +I +++ IGRPSTYA IV+TL +R YV E + +K LVPT+ +V +L+ ++ L+ Sbjct 441 TLIKTLEKLGIGRPSTYATIVKTLKERGYV-EVK-KKALVPTEIAFQVVEFLMERFPTLM 498 Query 1673 SEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEIL 1706 + T +EEK+DL+EEGKL++ V+Y+ +I Sbjct 499 DYKFTAQMEEKLDLVEEGKLNWKSVVYEFMEKIF 532 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Synechocystis sp. PCC 6803 substr. Kazusa] Sequence ID: P73810.1 Length: 898 Range 1: 2 to 341 Score:117 bits(292), Expect:5e-25, Method:Compositional matrix adjust., Identities:111/381(29%), Positives:175/381(45%), Gaps:80/381(20%) Query 642 SALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGY 701 S L+IVESP KARTI N+ P R+ E S+G++ + AS + ++ + Sbjct 2 SKLVIVESPTKARTIRNYL--PQDYRV------EASMGHVR-DLPASAEEVPAAYKDKSW 52 Query 702 HGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRE 761 + + + + F P+Y V P+ V++ ++ Sbjct 53 ANLGVNVEDH---FSPLY--------------------VIPKSKKKVVKE-------LQT 82 Query 762 LAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVN 821 + DE+++ATD D EGE I+W + +L P P IKR+ FHE+T+ AI A++ RD++ Sbjct 83 ALKNADEVILATDEDREGESISWHLLQLLQPKVP-IKRMVFHEITQEAIRSALENCRDID 141 Query 822 EGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK-------- 873 E V+AQ RRI DR +G+ LS L + LSAGRVQ+ + I++R + Sbjct 142 ENLVHAQETRRILDRLVGYTLSPLLWKKIA-WGLSAGRVQSVAVRLIVQRERARRAFKTA 200 Query 874 -------EFSESETYFL-------GLTLENGLQFTVEIGK-----------DGKEVEPPE 908 E +++ F G L NG F G + + + E Sbjct 201 GYWDLKAELEQNKNPFQAKLMTLGGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALKE 260 Query 909 YVTVEK---VELEEKEF--NPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVT 963 +T + V EEK P PP+TT + ++A+ L +SA +TMR+AQ L+E G Sbjct 261 RLTGKPWAVVNTEEKPGVRKPSPPFTTSTLQQEANRKLGISARDTMRVAQKLYEEGYITY 320 Query 964 PDT-LVSLSDGRIMEIKEAVE 983 T V LSD + + V+ Sbjct 321 MRTDSVHLSDQAVTAARNCVQ 341 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus RF122] Sequence ID: Q2YXL8.2 Length: 689 Range 1: 297 to 545 Score:115 bits(288), Expect:1e-24, Method:Compositional matrix adjust., Identities:88/267(33%), Positives:137/267(51%), Gaps:37/267(13%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPR----HWGEEGTHEAIRPTRPIDTGRL 1506 TY RTDST +S+T AK+YIT + GE Y R G++ HEAIRP+ + T Sbjct 297 TYMRTDSTRISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDD 356 Query 1507 MQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEG-- 1564 M+ LT++ YRLY +I+ RF+ SQM A L I G K G Sbjct 357 MKSF----------LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT 406 Query 1565 ---------YVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVE---AKKWKAPKVQLYSQG 1612 YVE +D + S +LP+L++G K+ + A+ + P + Y++ Sbjct 407 IKFKGFMTLYVETKDD----IDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPR-YTEA 461 Query 1613 DIIAMMKERKIGRPSTYAKIVQTLLQRYYV-FETRGRKKLVPTDKGIKVYHYLVTKYKDL 1671 ++ ++E KIGRPSTYA + T+ +R YV E+ K+ VPT+ G V+ + + ++ Sbjct 462 RLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLES---KRFVPTELGEIVHEQVKEYFPEI 518 Query 1672 VSEEKTRSLEEKMDLIEEGKLDYLKVL 1698 + E T ++E +D I EG + + KV+ Sbjct 519 IDVEFTVNMETLLDKIAEGDITWRKVI 545 Range 2: 5 to 284 Score:102 bits(255), Expect:9e-21, Method:Compositional matrix adjust., Identities:91/334(27%), Positives:153/334(45%), Gaps:73/334(21%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V +++ + P Y TI+ G V VK +++ A Sbjct 44 VDTEDN-----YEPKYITIR---------------------GKGPV------VKELKKHA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ + +A+DPD EGE IAW + +L R+ F+E+T+ A+ ++ + R++ Sbjct 72 KKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMN 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK---------- 873 V+AQ RRI DR +G+ +S L + + + LSAGRVQ+ L +I+R Sbjct 132 LVDAQQARRILDRLVGYNISPVLWKKVK-KGLSAGRVQSVALRLVIDRENEIRNFKPEEY 190 Query 874 -----EFSESETYFLGLTLE-NGLQFTVEIGKDGKEVEPP---EYVTVEKVELEEKEFNP 924 EF ++ F L F ++ KD +++ + + V +EK NP Sbjct 191 WIIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDIEKITAALDGDQFEITNVTKKEKTRNP 250 Query 925 QPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P+TT + ++A+ L A +TM +AQ L+E Sbjct 251 ANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme; Contains: RecName: Full=Endonuclease PI-PfuI; AltName: Full=Pfu topA intein [Pyrococcus furiosus DSM 3638] Sequence ID: O73954.2 Length: 1060 Range 1: 653 to 930 Score:116 bits(290), Expect:1e-24, Method:Compositional matrix adjust., Identities:93/296(31%), Positives:140/296(47%), Gaps:37/296(12%) Query 1416 VKVKEVEEEHYTGKLYDFTTTT-ENFLSNGAVSHNCTYHRTDSTHVSN-----------T 1463 + +K +E+ HY GK+YD NF++NG HNC+Y RT+S + Sbjct 653 IGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLA 712 Query 1464 GIEVAKEYITQEVGEEYFKPRHW-GEEGTHEAIRPTRPIDTGRLMQLVRDGIIQLPKNLT 1522 I + Y +G KP E+ H AI PT G I P +LT Sbjct 713 RIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPT--------------GEIPRPGDLT 758 Query 1523 RNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGYVEIIEDGWTKLRSPNFR 1582 ++ LYDMI RRF+ M+ A + I AG K + G +++GW ++ + Sbjct 759 KDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISG-GRTVKEGWLRVYGKYVK 817 Query 1583 ----QLPRLKEGAKLKVVEAK--KWKAPKVQLYSQGDIIAMMKERKIGRPSTYAKIVQTL 1636 LP G ++KV++ K K K YS +I M++ +G +T A+I++TL Sbjct 818 FDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETL 877 Query 1637 LQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLIEEGKL 1692 QR Y+ G+K + T G+KV L +++S E TR E+KM+LI EGKL Sbjct 878 YQRGYI---EGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKL 930 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus MSSA476] Sequence ID: Q6G9W3.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus MRSA252] Sequence ID: Q6GHI5.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus N315] Sequence ID: Q7A5Y5.1 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus MW2] Sequence ID: Q8NWZ9.2 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus Mu50] Sequence ID: Q99UM1.1 Length: 689 Range 1: 297 to 545 Score:115 bits(287), Expect:1e-24, Method:Compositional matrix adjust., Identities:88/267(33%), Positives:136/267(50%), Gaps:37/267(13%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPR----HWGEEGTHEAIRPTRPIDTGRL 1506 TY RTDST +S+T AK+YIT + GE Y R G++ HEAIRP+ + T Sbjct 297 TYMRTDSTRISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDD 356 Query 1507 MQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEG-- 1564 M+ LT++ YRLY +I+ RF+ SQM A L I G K G Sbjct 357 MKSF----------LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT 406 Query 1565 ---------YVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVE---AKKWKAPKVQLYSQG 1612 YVE +D S +LP+L++G K+ + A+ + P + Y++ Sbjct 407 IKFKGFMTLYVETKDDS----DSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPR-YTEA 461 Query 1613 DIIAMMKERKIGRPSTYAKIVQTLLQRYYV-FETRGRKKLVPTDKGIKVYHYLVTKYKDL 1671 ++ ++E KIGRPSTYA + T+ +R YV E+ K+ VPT+ G V+ + + ++ Sbjct 462 RLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLES---KRFVPTELGEIVHEQVKEYFPEI 518 Query 1672 VSEEKTRSLEEKMDLIEEGKLDYLKVL 1698 + E T ++E +D I EG + + KV+ Sbjct 519 IDVEFTVNMETLLDKIAEGDITWRKVI 545 Range 2: 5 to 284 Score:103 bits(256), Expect:8e-21, Method:Compositional matrix adjust., Identities:91/334(27%), Positives:153/334(45%), Gaps:73/334(21%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V +++ + P Y TI+ G V VK +++ A Sbjct 44 VDTEDN-----YEPKYITIR---------------------GKGPV------VKELKKHA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ + +A+DPD EGE IAW + +L R+ F+E+T+ A+ ++ + R++ Sbjct 72 KKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMN 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK---------- 873 V+AQ RRI DR +G+ +S L + + + LSAGRVQ+ L +I+R Sbjct 132 LVDAQQARRILDRLVGYNISPVLWKKVK-KGLSAGRVQSVALRLVIDRENEIRNFKPEEY 190 Query 874 -----EFSESETYFLGLTLE-NGLQFTVEIGKDGKEVEPP---EYVTVEKVELEEKEFNP 924 EF ++ F L F ++ KD +++ + + V +EK NP Sbjct 191 WTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNP 250 Query 925 QPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P+TT + ++A+ L A +TM +AQ L+E Sbjct 251 ANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus] Sequence ID: Q06AK7.1 Length: 689 Range 1: 297 to 545 Score:115 bits(287), Expect:1e-24, Method:Compositional matrix adjust., Identities:88/267(33%), Positives:136/267(50%), Gaps:37/267(13%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPR----HWGEEGTHEAIRPTRPIDTGRL 1506 TY RTDST +S+T AK+YIT + GE Y R G++ HEAIRP+ + T Sbjct 297 TYMRTDSTRISDTAKAEAKQYITNKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDD 356 Query 1507 MQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEG-- 1564 M+ LT++ YRLY +I+ RF+ SQM A L I G K G Sbjct 357 MKSF----------LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT 406 Query 1565 ---------YVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVE---AKKWKAPKVQLYSQG 1612 YVE +D S +LP+L++G K+ + A+ + P + Y++ Sbjct 407 IKFKGFMTLYVETKDDS----DSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPR-YTEA 461 Query 1613 DIIAMMKERKIGRPSTYAKIVQTLLQRYYV-FETRGRKKLVPTDKGIKVYHYLVTKYKDL 1671 ++ ++E KIGRPSTYA + T+ +R YV E+ K+ VPT+ G V+ + + ++ Sbjct 462 RLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLES---KRFVPTELGEIVHEQVKEYFPEI 518 Query 1672 VSEEKTRSLEEKMDLIEEGKLDYLKVL 1698 + E T ++E +D I EG + + KV+ Sbjct 519 IDVEFTVNMETLLDKIAEGDITWRKVI 545 Range 2: 5 to 284 Score:102 bits(255), Expect:9e-21, Method:Compositional matrix adjust., Identities:91/334(27%), Positives:153/334(45%), Gaps:73/334(21%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V +++ + P Y TI+ G V VK +++ A Sbjct 44 VDTEDN-----YEPKYITIR---------------------GKGPV------VKELKKHA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ + +A+DPD EGE IAW + +L R+ F+E+T+ A+ ++ + R++ Sbjct 72 KKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMN 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK---------- 873 V+AQ RRI DR +G+ +S L + + + LSAGRVQ+ L +I+R Sbjct 132 LVDAQQARRILDRLVGYNISPVLWKKVK-KGLSAGRVQSVALRLVIDRENEIRNFKPEEY 190 Query 874 -----EFSESETYFLGLTLE-NGLQFTVEIGKDGKEVEPP---EYVTVEKVELEEKEFNP 924 EF ++ F L F ++ KD +++ + + V +EK NP Sbjct 191 WTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITTALDGDQFEITNVTKKEKTRNP 250 Query 925 QPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P+TT + ++A+ L A +TM +AQ L+E Sbjct 251 ANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Thermotoga maritima MSB8] Sequence ID: P46799.1 Length: 633 Range 1: 1 to 275 Score:114 bits(286), Expect:1e-24, Method:Compositional matrix adjust., Identities:104/339(31%), Positives:156/339(46%), Gaps:76/339(22%) Query 632 ISAKVKDLVKSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGH 691 +S KVK + +VESP KA+TI + G YEV AS GH Sbjct 1 MSKKVKKYI-----VVESPAKAKTIKSILGN----------EYEV---------FASMGH 36 Query 692 MFDLVTNEGYHGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRD 751 + DL ++ GV ++ D F P + IK + D +KG Sbjct 37 IIDLPKSK--FGVDLEKD-----FEPEFAVIKGKEKVVEKLKDLAKKG------------ 77 Query 752 ALDNVKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIM 811 E+LIA+D D EGE IAW I V + RI F E+T I Sbjct 78 ----------------ELLIASDMDREGEAIAWHIARVTNTLGRK-NRIVFSEITPRVIR 120 Query 812 KAIQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIER 871 +A++ R+++ +V AQ+ RRI DR +G+ LS L R F++ NLSAGRVQ+ L + +R Sbjct 121 EAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKS-NLSAGRVQSATLKLVCDR 179 Query 872 YKE--------FSESETYFLGLTLENGLQ----FTVEIGKDGKEVEPPEYVTVEKVELEE 919 +E + F GLT E ++ F E KE++ + + VE+ ++ Sbjct 180 EREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAET---LKEIQSIDELVVEEKKVSV 236 Query 920 KEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 K+F P P+ T + ++A + L S +TM +AQ L+E Sbjct 237 KKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEG 275 Range 2: 287 to 536 Score:113 bits(283), Expect:3e-24, Method:Compositional matrix adjust., Identities:91/263(35%), Positives:135/263(51%), Gaps:24/263(9%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYF------KPRHWGEEGTHEAIRPTRPIDTG 1504 TY RTDST VS+ E A+ IT+ GEEY + + + HEAIRPT T Sbjct 287 TYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTP 346 Query 1505 RLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEG 1564 + K L + +LY++I++RF+ SQMK ++ R V+ GK +G Sbjct 347 E----------EAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKG 396 Query 1565 YV-EIIEDGWTKL--RSPNFRQLPRLKEGAKLK--VVEAKKWKAPKVQLYSQGDIIAMMK 1619 V + I DG+ K+ N + P +EG +K VV+ ++ + Y++G ++ M+ Sbjct 397 TVLKKIFDGYEKVWKTERNTGEFP-FEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEME 455 Query 1620 ERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRS 1679 IGRPSTYA ++ LL R Y+ + RG L PT G V YL KY D+VS T Sbjct 456 RLGIGRPSTYASTIKLLLNRGYIKKIRGY--LYPTIVGSVVMDYLEKKYSDVVSVSFTAE 513 Query 1680 LEEKMDLIEEGKLDYLKVLYDLY 1702 +E+ +D +E+GK VL + Y Sbjct 514 MEKDLDEVEQGKKTDKIVLREFY 536 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus USA300] Sequence ID: Q2FHI8.2 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus NCTC 8325] Sequence ID: Q2FZ32.2 Length: 689 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus aureus subsp. aureus COL] Sequence ID: Q5HGI2.1 Length: 689 Range 1: 297 to 545 Score:114 bits(284), Expect:3e-24, Method:Compositional matrix adjust., Identities:88/267(33%), Positives:136/267(50%), Gaps:37/267(13%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPR----HWGEEGTHEAIRPTRPIDTGRL 1506 TY RTDST +S+T AK+YIT + GE Y R G++ HEAIRP+ + T Sbjct 297 TYMRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDD 356 Query 1507 MQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEG-- 1564 M+ LT++ YRLY +I+ RF+ SQM A L I G K G Sbjct 357 MKSF----------LTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQT 406 Query 1565 ---------YVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVE---AKKWKAPKVQLYSQG 1612 YVE +D S +LP+L++G K+ + A+ + P + Y++ Sbjct 407 IKFKGFMTLYVETKDDS----DSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPR-YTEA 461 Query 1613 DIIAMMKERKIGRPSTYAKIVQTLLQRYYV-FETRGRKKLVPTDKGIKVYHYLVTKYKDL 1671 ++ ++E KIGRPSTYA + T+ +R YV E+ K+ VPT+ G V+ + + ++ Sbjct 462 RLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLES---KRFVPTELGEIVHEQVKEYFPEI 518 Query 1672 VSEEKTRSLEEKMDLIEEGKLDYLKVL 1698 + E T ++E +D I EG + + KV+ Sbjct 519 IDVEFTVNMETLLDKIAEGDITWRKVI 545 Range 2: 5 to 284 Score:102 bits(255), Expect:8e-21, Method:Compositional matrix adjust., Identities:91/334(27%), Positives:153/334(45%), Gaps:73/334(21%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V +++ + P Y TI+ G V VK +++ A Sbjct 44 VDTEDN-----YEPKYITIR---------------------GKGPV------VKELKKHA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ + +A+DPD EGE IAW + +L R+ F+E+T+ A+ ++ + R++ Sbjct 72 KKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMN 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK---------- 873 V+AQ RRI DR +G+ +S L + + + LSAGRVQ+ L +I+R Sbjct 132 LVDAQQARRILDRLVGYNISPVLWKKVK-KGLSAGRVQSVALRLVIDRENEIRNFKPEEY 190 Query 874 -----EFSESETYFLGLTLE-NGLQFTVEIGKDGKEVEPP---EYVTVEKVELEEKEFNP 924 EF ++ F L F ++ KD +++ + + V +EK NP Sbjct 191 WTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNP 250 Query 925 QPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P+TT + ++A+ L A +TM +AQ L+E Sbjct 251 ANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Rickettsia bellii RML369-C] Sequence ID: Q1RIM1.1 Length: 800 Range 1: 3 to 330 Score:114 bits(285), Expect:3e-24, Method:Compositional matrix adjust., Identities:109/383(28%), Positives:176/383(45%), Gaps:93/383(24%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G K ++AS GH+ DL + +G Sbjct 3 LVIVESPAKAKTINKYLGDEFK-------------------VIASFGHIRDLPSKKG--- 40 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 +I ++ +K YD ++ ++VD A+ + A Sbjct 41 SVIPDENFSMK----YDISEK----AGKYVD-----------------------AIIKDA 69 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPN-----IKRIEFHEVTRPAIMKAIQEAR 818 ++ + + +ATDPD EGE I+W I V+ KR+ F+E+T+ AI AI+ R Sbjct 70 KKAESVYLATDPDREGESISWHIAEVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPR 129 Query 819 DVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFS-- 876 ++ VNAQ RR D +GF LS L R SAGRVQ+ L I ER E Sbjct 130 KLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCK-SAGRVQSVALRLICEREDEIERF 188 Query 877 ESETYF---LGLTLENGLQFTVEI------------------GKDGKEVEPPEYVTVEKV 915 +SE Y+ L + N FT ++ KD E + V+K+ Sbjct 189 KSEEYWDISLKMLNSNNELFTAKLTHINDQKLEKFSITNDKEAKDLTEKLKSQNFHVDKI 248 Query 916 ELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTL-------- 967 E ++++ PQPP+ T ++ ++A+ L SA +TM++AQ L+E G+ + +T+ Sbjct 249 EKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYE-GVDIGKETIGLITYMRT 307 Query 968 --VSLSDGRIMEIKEAVEGSEGN 988 V+LS+ + EI++ + G+ Sbjct 308 DGVTLSNDAVDEIRKLINKDYGD 330 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Xylella fastidiosa Temecula1] Sequence ID: Q87AQ6.1 Length: 815 Range 1: 5 to 293 Score:114 bits(285), Expect:3e-24, Method:Compositional matrix adjust., Identities:103/343(30%), Positives:157/343(45%), Gaps:83/343(24%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ T+LAS GH+ DLV EG Sbjct 5 LLIVESPAKAKTINKYLGKD-------------------FTVLASYGHVRDLVPKEG--- 42 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 + +G +++ +D +K +V+A+ + A Sbjct 43 AVDPENGFAMRY---------------DLIDKNEK----------------HVEAITKAA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSP----YTPNIKRIEFHEVTRPAIMKAIQEARD 819 + D I +ATDPD EGE I+W I +L ++RI F E+T AI +AIQ+ R Sbjct 72 KTADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRM 131 Query 820 VNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---FS 876 + V+AQ RR D +GF LS L R + R LSAGRVQ+P L I+ER +E F Sbjct 132 IASDLVDAQQARRALDYLVGFNLSPVLWRKVQ-RGLSAGRVQSPALRMIVEREEEIEAFI 190 Query 877 ESETYFLGLTLENGLQ-FTVEIGK-DGKEVE--------------------PPEYVTVEK 914 E + + + Q F+ ++ K DGK+ E + + Sbjct 191 TREYWSIHAECTHPAQHFSAKLIKLDGKKFEQFTITDSDTAAAAQRRIQQAAQGRLHITD 250 Query 915 VELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFE 957 V +E++ P PP+ T + ++AS L + +TM++AQ L+E Sbjct 251 VTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYE 293 Range 2: 306 to 562 Score:90.1 bits(222), Expect:1e-16, Method:Compositional matrix adjust., Identities:72/272(26%), Positives:133/272(48%), Gaps:38/272(13%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYF--KPRHW-----GEEGTHEAIRPTRPID 1502 TY RTDS ++S + ++ I ++ G KP + + HEA+RPT + Sbjct 306 ITYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALR 365 Query 1503 TGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAEL 1562 T Q+ L+ +RLY+++++R + SQM A ++ +D G + Sbjct 366 TP----------TQVAPYLSNEEHRLYELVWKRTVASQMIPA--ILNTTSVDLAAGNEHV 413 Query 1563 ----------EGYVEIIEDGWTKLRSPN---FRQLPRLKEGAKL---KVVEAKKWKAPKV 1606 +G++ + E+G + + R+LP +K G + +++ + + P Sbjct 414 FRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPP 473 Query 1607 QLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVT 1666 + Y++ ++ ++E IGRPSTYA I+QTLL R YV + GR PTD G V +L + Sbjct 474 R-YTEAALVKALEEYGIGRPSTYASIIQTLLFRKYV-DMEGR-SFRPTDIGRAVSKFLSS 530 Query 1667 KYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVL 1698 + V + T LE+++D I G+ +++ ++ Sbjct 531 HFTQYVDYDFTAHLEDELDAISRGEEEWIPLM 562 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821] Sequence ID: Q9X3X7.3 Length: 1212 Range 1: 3 to 292 Score:114 bits(286), Expect:3e-24, Method:Compositional matrix adjust., Identities:101/344(29%), Positives:156/344(45%), Gaps:79/344(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L++VESP KA+TI + G Y+V LAS GH+ DL + +G Sbjct 3 LVVVESPAKAKTIEKYLGS----------GYQV---------LASYGHIRDLPSKDG--- 40 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 P D G V W+ N D +KA+ + Sbjct 41 ----------SVNP---------DNGFSMV-WQ-----------NYPDKAHRLKAIEDAV 69 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYT---PNIKRIEFHEVTRPAIMKAIQEARDV 820 +E D +++ATDPD EGE I+W I +L +++R+ F+ +T+ A+ A+ R + Sbjct 70 KESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQL 129 Query 821 NEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---FSE 877 + +NA + RR D +GF LS L R SAGRVQ+ L +++R +E F Sbjct 130 DNDLINAYLARRALDYLVGFTLSPILWRKLPGAK-SAGRVQSVALRLVVDREQEIEGFKP 188 Query 878 SETYFLGLTLE-NGLQFTVEI----GK--------DGKEVEPPE------YVTVEKVELE 918 E + + +E + + FT + G+ D + E + + TV VE + Sbjct 189 QEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETK 248 Query 919 EKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCV 962 NPQPP+TT + ++A+ L +A TMRLAQ L+E GL Sbjct 249 PVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLIT 292 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Xylella fastidiosa 9a5c] Sequence ID: Q9PEV8.1 Length: 815 Range 1: 5 to 293 Score:113 bits(282), Expect:6e-24, Method:Compositional matrix adjust., Identities:102/343(30%), Positives:157/343(45%), Gaps:83/343(24%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ T+LAS GH+ DLV EG Sbjct 5 LLIVESPAKAKTINKYLGKD-------------------FTVLASYGHVRDLVPKEG--- 42 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 + +G +++ +D +K +V+A+ + A Sbjct 43 AVDPENGFAMRY---------------DLIDKNEK----------------HVEAITKAA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSP----YTPNIKRIEFHEVTRPAIMKAIQEARD 819 + D I +ATDPD EGE I+W I +L ++RI F E+T AI +AIQ+ R Sbjct 72 KTADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRM 131 Query 820 VNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---FS 876 + V+AQ RR D +GF LS L R + R LSAGRVQ+P L I+ER +E F Sbjct 132 IASDLVDAQQARRALDYLVGFNLSPVLWRKVQ-RGLSAGRVQSPALRMIVEREEEIEAFI 190 Query 877 ESETYFLGLTLENGLQ-FTVEIGK-DGKEVE--------------------PPEYVTVEK 914 E + + + Q F+ ++ K DG++ E + + Sbjct 191 TREYWSIHAECAHPAQHFSAKLIKLDGQKFEQFTITDSDTAAAAQRRIQQVAQGRLHITD 250 Query 915 VELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFE 957 V +E++ P PP+ T + ++AS L + +TM++AQ L+E Sbjct 251 VTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYE 293 Range 2: 306 to 562 Score:90.1 bits(222), Expect:8e-17, Method:Compositional matrix adjust., Identities:72/272(26%), Positives:133/272(48%), Gaps:38/272(13%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYF--KPRHW-----GEEGTHEAIRPTRPID 1502 TY RTDS ++S + ++ I ++ G KP + + HEA+RPT + Sbjct 306 ITYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALR 365 Query 1503 TGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAEL 1562 T Q+ L+ +RLY+++++R + SQM A ++ +D G + Sbjct 366 TP----------TQVAPYLSNEEHRLYELVWKRAVASQMIPA--ILNTTSVDLAAGNEHV 413 Query 1563 ----------EGYVEIIEDGWTKLRSPN---FRQLPRLKEGAKL---KVVEAKKWKAPKV 1606 +G++ + E+G + + R+LP +K G + +++ + + P Sbjct 414 FRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPP 473 Query 1607 QLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVT 1666 + Y++ ++ ++E IGRPSTYA I+QTLL R YV + GR PTD G V +L + Sbjct 474 R-YTEAALVKALEEYGIGRPSTYASIIQTLLFRKYV-DMEGR-SFRPTDIGRAVSKFLAS 530 Query 1667 KYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVL 1698 + V + T LE+++D I G+ +++ ++ Sbjct 531 HFTRYVDYDFTAHLEDELDAISRGEEEWIPLM 562 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Helicobacter pylori 26695] Sequence ID: P55991.1 Length: 736 Range 1: 4 to 283 Score:112 bits(281), Expect:8e-24, Method:Compositional matrix adjust., Identities:101/334(30%), Positives:156/334(46%), Gaps:74/334(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI NF + YEV +AS GH+ DL ++ G Sbjct 4 LIIVESPAKAKTIKNFLDK----------NYEV---------IASKGHVRDL--SKFALG 42 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 + I G F P Y VD + K + VK + EL+ Sbjct 43 IKIDETG----FTPNY------------VVDKDHKEL---------------VKQIIELS 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ IATD D EGE I + + ++ + RI FHE+T+ AI+ A++ R ++ Sbjct 72 KKASITYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRKIDMS 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESE--TY 881 +VNAQ RR DR +GF+LS + + LSAGRVQ+ L +I++ +E + TY Sbjct 132 KVNAQQARRFLDRIVGFKLSSLIASKI-TKGLSAGRVQSAALKLVIDKEREIKAFKPLTY 190 Query 882 F-LGLTLENGLQFTVEIGKDGKEVEPPEYVTVEKV-----ELEEKEFNPQ---------- 925 F L E+ L+ + I G +++ E + +K ELE++ + Sbjct 191 FTLDAYFESHLEAQL-ISYKGNKLKAQELIDEKKAQEIKNELEKESYAISSIVKKSKKSP 249 Query 926 --PPYTTDAMLKDASTFLKLSAPETMRLAQDLFE 957 PP+ T + + AS+ L S +TM +AQ L+E Sbjct 250 TPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYE 283 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q59046.1 Length: 761 Range 1: 4 to 318 Score:112 bits(280), Expect:1e-23, Method:Compositional matrix adjust., Identities:95/345(28%), Positives:157/345(45%), Gaps:48/345(13%) Query 640 VKSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNE 699 + +AL+I E P+ A+ IAN G+ K I + YE+ + + ++ GH+F LV E Sbjct 4 IMTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKE 63 Query 700 GYHGVIIQNDGNMLKFIPVYDT--IKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVK 757 F PV+D + D G ++V+ +K Sbjct 64 NKE----------FGFYPVFDIKWVPASVDKGKEYVN-------------------KYIK 94 Query 758 AMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEA 817 A+++L+++ DE IATD D EGE I + KR+ F +T+ I++A + Sbjct 95 ALKKLSKDADEFYIATDWDIEGELIGYHALKYCCGRE-KAKRMRFSSLTKKEIVRAFENP 153 Query 818 RDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRN----LSAGRVQTPVLGWIIER-- 871 +++ G V+A R I D + G LS+ L N +S GRVQ P L ++ ER Sbjct 154 DEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTEREL 213 Query 872 -YKEFSESETYFLGLTLENGLQFTVEIGKDGKEVEPP---EYVTVEK----VELE--EKE 921 K+F + + L++ L+ E K E E E + EK VE++ +++ Sbjct 214 EIKKFIPKPYWVIEALLKDNLKAIHEKEKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRK 273 Query 922 FNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDT 966 P PP+ + ++A ++ K+S ET +AQ L+E L P T Sbjct 274 LKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALISYPRT 318 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus haemolyticus JCSC1435] Sequence ID: Q4L5V2.1 Length: 689 Range 1: 297 to 549 Score:112 bits(279), Expect:1e-23, Method:Compositional matrix adjust., Identities:81/269(30%), Positives:139/269(51%), Gaps:33/269(12%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPR----HWGEEGTHEAIRPTRPIDTGRL 1506 TY RTDST +S T + AK+YI + G++Y R G++ HEAIRPT + T Sbjct 297 TYMRTDSTRISQTAKDEAKQYIEDKYGKDYLSNRTAKGKQGDQDAHEAIRPTSTLRTPYE 356 Query 1507 MQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVID---------AGV 1557 M+ LTR+ +RLY +I+ RF+ SQM A +++ +D A Sbjct 357 MKAY----------LTRDQHRLYKLIWERFVASQMAPA--ILDTVALDVTQNNIKFRANG 404 Query 1558 GKAELEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVE---AKKWKAPKVQLYSQGDI 1614 + +G++ + + + +LP L +G ++ + A+ + P + Y++ + Sbjct 405 QTIKFKGFMTLYVEAKDDKDNEKENKLPNLSKGDEVTATQIEPAQHFTQPPPR-YTEARL 463 Query 1615 IAMMKERKIGRPSTYAKIVQTLLQRYYV-FETRGRKKLVPTDKGIKVYHYLVTKYKDLVS 1673 + ++E KIGRPSTYA + T+ +R YV E+ K+ VPT+ G VY + + +++ Sbjct 464 VKTLEELKIGRPSTYAPTIDTIQKRNYVKLES---KRFVPTELGEIVYEQVKDYFPEIID 520 Query 1674 EEKTRSLEEKMDLIEEGKLDYLKVLYDLY 1702 E T ++E +D I EG + + KV+ + Y Sbjct 521 VEFTVNMETLLDKIAEGDIGWRKVIDNFY 549 Range 2: 5 to 284 Score:106 bits(264), Expect:8e-22, Method:Compositional matrix adjust., Identities:93/334(28%), Positives:153/334(45%), Gaps:73/334(21%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V ++++ + P Y TI+ G V VK +++ A Sbjct 44 VDVEDN-----YEPKYITIR---------------------GKGPV------VKDLKKYA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ + +A+DPD EGE IAW + +L R+ F+E+T+ A+ ++ + R + Sbjct 72 KKAKNVFLASDPDREGEAIAWHLSKILELDDSKENRVVFNEITKDAVKESFKHPRGIEMD 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK---------- 873 V+AQ RRI DR +G+ +S L + + + LSAGRVQ+ L +I+R Sbjct 132 LVDAQQARRILDRLVGYNISPVLWKKVK-KGLSAGRVQSVALRLVIDRENEIRNFKPEEY 190 Query 874 -----EFSESETYFLGLTLE-NGLQFTVEIGKDGKEVEPP---EYVTVEKVELEEKEFNP 924 EF ++ F L F ++ KD ++V + + V +EK NP Sbjct 191 WSIEGEFRYKKSKFTAKFLHYKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNP 250 Query 925 QPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P+TT + ++A+ L A +TM LAQ L+E Sbjct 251 ANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Fervidobacterium islandicum] Sequence ID: O34204.1 Length: 699 Range 1: 323 to 578 Score:111 bits(278), Expect:2e-23, Method:Compositional matrix adjust., Identities:88/273(32%), Positives:139/273(50%), Gaps:36/273(13%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYFKPRH-----------WGEEGTHEAIRPTR 1499 TY RTDST VS+ E A+++I + G EY + HE IRP Sbjct 323 TYMRTDSTRVSDVAKEAAEKFILKNFGREYLNESSEVASKKGSKTKGKVQDAHECIRP-- 380 Query 1500 PIDTGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGK 1559 +D + ++ L ++H++LY++I++RF+ SQM +A + ++ D GK Sbjct 381 -VDVNITPEKAKEL-------LDKDHHKLYELIWKRFIASQMSSA--IYKQYSYDFESGK 430 Query 1560 AELEGYV-EIIEDGWTKLRSPNFRQLPRLKEGAKLKV-----VEAKKWKAPKV--QLYSQ 1611 E + E I DG+ K+ + + + KE LKV VE K +A Y++ Sbjct 431 YVFEASIRERIFDGFEKVYTIDNEPSEKHKE---LKVDQEYLVEPKSAEAQTTPPDRYTE 487 Query 1612 GDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDL 1671 ++ ++ IGRPSTYA I+QTLL R YV + RK L+PT G V HYL ++ D+ Sbjct 488 ASLVKTLEMEGIGRPSTYATIIQTLLDRGYV--VKKRKTLIPTILGFVVNHYLEQRFPDI 545 Query 1672 VSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNE 1704 V + T +E+++D +E GK D+ +V+ E Sbjct 546 VDKGFTAEMEKELDEVENGKKDWKEVVKSFLKE 578 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Lactococcus lactis subsp. lactis Il1403] Sequence ID: Q9CG80.1 Length: 710 Range 1: 308 to 567 Score:111 bits(278), Expect:2e-23, Method:Compositional matrix adjust., Identities:86/279(31%), Positives:134/279(48%), Gaps:36/279(12%) Query 1441 LSNGAVSHN--CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYFK-----PRHWGEEGTHE 1493 L+ G+ H TY RTDST +S A YI + GE+Y K G + HE Sbjct 308 LTLGSQGHQGLITYMRTDSTRISPVAQSAAHNYIADQFGEKYSKHGSKVKNASGAQDAHE 367 Query 1494 AIRPTRPIDTGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAA-------KL 1546 AIRP+ +T D I K L ++ +LY +I+ RF+ SQM AA L Sbjct 368 AIRPSNVFNTP-------DAIA---KYLDKDQLKLYTLIWNRFVASQMVAAIFDTVKVNL 417 Query 1547 LMERAVIDAGVGKAELEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVEAK---KWKA 1603 + A + + +GY+ I D S LP ++E +K K + Sbjct 418 SQNGVIFIANGSQVKFDGYLRIYND------SDKSNMLPEMEENETVKKANVKPEQHFTQ 471 Query 1604 PKVQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHY 1663 P + YS+ +I ++E +GRPSTYA ++T+ +RYYV K+ PT+ G V Sbjct 472 PPAR-YSEATLIKTLEENGVGRPSTYAPTLETIQKRYYV--RLSAKRFEPTELGEIVNKL 528 Query 1664 LVTKYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLY 1702 +V + ++V+ E T +E+ +D +EEGK +++V+ Y Sbjct 529 IVEFFPNIVNTEFTAEMEKDLDEVEEGKRQWIEVVDQFY 567 Range 2: 28 to 307 Score:107 bits(267), Expect:3e-22, Method:Compositional matrix adjust., Identities:95/335(28%), Positives:157/335(46%), Gaps:75/335(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL + Sbjct 28 LVIVESPAKAKTIEKYLGRNYK-------------------VVASVGHIRDL--KKSTMS 66 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V I+ND + P Y N+R + ++++ A Sbjct 67 VDIEND-----YEPQY---------------------------INIRGKAPLINSLKKEA 94 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 + + +A+DPD EGE I+W + ++L+ R+ F+E+T+ A+ A +E R ++ Sbjct 95 KAAKAVYLASDPDREGEAISWHLAHILNLPLEEKNRVVFNEITKDAVKNAFKEPRQIDVD 154 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---FSESET 880 V+AQ RR+ DR +G+ +S L + + + LSAGRVQ+ L I++R E F E Sbjct 155 LVDAQQARRVLDRLVGYSISPILWKKVK-KGLSAGRVQSIALKLIVDRENEINAFIPEEY 213 Query 881 YFLGLTLENGL-QFTVEI-GKDGKE---------------VEPPEYVTVEKVELEEKEFN 923 + + + G +F G DGK+ ++ P++ V+KVE +E+ N Sbjct 214 WSIDGEFKKGTKKFKASFWGIDGKKHPLKTNEDVIKVMERLDGPDF-NVDKVEKKERRRN 272 Query 924 PQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 PYTT +M +DA+ L +TM +AQ L+E Sbjct 273 APLPYTTSSMQQDAANKLNFRTRKTMMVAQQLYEG 307 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Pasteurella multocida subsp. multocida str. Pm70] Sequence ID: Q9CN30.1 Length: 868 Range 1: 4 to 321 Score:111 bits(278), Expect:2e-23, Method:Compositional matrix adjust., Identities:109/345(32%), Positives:158/345(45%), Gaps:55/345(15%) Query 643 ALMIVESPNKARTIANFFG-----QPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVT 697 +L+IVESP KA+TI + G + S I DL S G I G ++ Sbjct 4 SLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKG------LS 57 Query 698 NEGYHGVIIQNDGNMLKFIPVYDTIKRCR-DCGHQFVDWEQKGVCPRCGSTNVRDALDNV 756 E + + D N L +KR D HQ+ Q + P G V V Sbjct 58 AEEKSAIKQEKDRNAL--------VKRMGIDPYHQWKANYQ--ILP--GKEKV------V 99 Query 757 KAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQE 816 ++ LA++ D I +ATD D EGE IAW +R V+ R+ F+E+T+ AI +A ++ Sbjct 100 AELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFEK 159 Query 817 ARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFS 876 +N RVNAQ RR DR +GF +S L + R LSAGRVQ+ + ++ER +E Sbjct 160 PEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVA-RGLSAGRVQSVAVKLVVEREREIK 218 Query 877 --ESETYF-----LGLTLENGLQFTVEIGKDGKEVEP---------------PEYVTVEK 914 + E Y+ + L+ V K GK+ EP +YV V Sbjct 219 AFQPEEYWEIDVLTQTQAKQALRLAVTQFK-GKKFEPKNATQAQSAVDFLQHADYV-VSD 276 Query 915 VELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 +E + + P+ T + + AST L +TM LAQ L+EAG Sbjct 277 LETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAG 321 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Helicobacter pylori J99] Sequence ID: Q9ZMV7.1 Length: 736 Range 1: 4 to 284 Score:111 bits(277), Expect:3e-23, Method:Compositional matrix adjust., Identities:102/335(30%), Positives:155/335(46%), Gaps:74/335(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI NF + YEV +AS GH+ DL ++ G Sbjct 4 LIIVESPAKAKTIKNFLDK----------NYEV---------VASKGHVRDL--SKFALG 42 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 + I G F P Y VD + K + VK + EL+ Sbjct 43 IKIDETG----FTPNY------------VVDKDHKEL---------------VKQIIELS 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ IATD D EGE I + + ++ + RI FHE+T+ AI+ ++ R ++ Sbjct 72 KKASITYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNVLKTPRKIDMF 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESE--TY 881 +VNAQ RR+ DR +GF+LS + + LSAGRVQ+ L +I+R KE + TY Sbjct 132 KVNAQQARRLLDRIVGFKLSSLIASKI-TKGLSAGRVQSAALKLVIDREKEIRPFKPLTY 190 Query 882 F-LGLTLENGLQFTVEIGKDGKEVEPPEYVTVEKV-----ELEEKEFN------------ 923 F L E L+ + I G +++ E + +K ELE++ + Sbjct 191 FTLDALFEPHLEAQL-ISYKGNKLKAQELIDEKKAQEIKNELEKESYIISSIIKKSKKSP 249 Query 924 PQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 PP+ T + + AS+ L S +TM +AQ L+E Sbjct 250 TPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Treponema pallidum subsp. pallidum str. Nichols] Sequence ID: O83409.1 Length: 731 Range 1: 311 to 562 Score:110 bits(276), Expect:3e-23, Method:Compositional matrix adjust., Identities:87/265(33%), Positives:129/265(48%), Gaps:26/265(9%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYF-KPRHWGEEG----THEAIRPTRPIDTGR 1505 TY RTDS VS ++ + +I + P + +G HEAIRPT T Sbjct 311 TYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPNRYAAKGKSQDAHEAIRPTYVAHTPE 370 Query 1506 LMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAELEGY 1565 ++ +LTR+ RLY +I+ RF+ SQM A++ I AG Sbjct 371 ----------RIKAHLTRDQIRLYTLIWERFVASQMTDARVRSLTFEITAGPAVFSATE- 419 Query 1566 VEIIEDGW---TKLRSP---NFRQLPRLKEG--AKLKVVEAKKWKAPKVQLYSQGDIIAM 1617 ++IE G+ K+ SP + LP KEG L V++ + Y+ I+ M Sbjct 420 TQVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKM 479 Query 1618 MKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKT 1677 ++E+ IGRPSTYA + LL RYYV TR +K+L+PT G + L T + D+V T Sbjct 480 LEEKGIGRPSTYAPTISVLLDRYYV--TRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFT 537 Query 1678 RSLEEKMDLIEEGKLDYLKVLYDLY 1702 +E K+D +EE K+ + V+ D Y Sbjct 538 ARMESKLDEVEEDKIKWNCVIADFY 562 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Haemophilus influenzae Rd KW20] Sequence ID: P43012.1 Length: 868 Range 1: 4 to 321 Score:111 bits(277), Expect:3e-23, Method:Compositional matrix adjust., Identities:103/347(30%), Positives:164/347(47%), Gaps:59/347(17%) Query 643 ALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNM--MLTILASGGHMFDLVTNEG 700 +L+IVESP KA+TI + +G + S+G++ + T+ +S G ++ +G Sbjct 4 SLVIVESPAKAKTINKY--------LGSQYVVKSSVGHIRDLPTVGSSTGEKAKPISTKG 55 Query 701 YHG-----VIIQNDGNMLKFIPVYDTIKRCR-DCGHQFVDWEQK-GVCPRCGSTNVRDAL 753 + + + N L +KR D H DW+ + P G V Sbjct 56 MDAEEKAKIKAEKERNAL--------VKRMGIDPYH---DWKANYQILP--GKEKV---- 98 Query 754 DNVKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKA 813 V ++ LA++ D I +ATD D EGE IAW +R V+ R+ F+E+T+ AI +A Sbjct 99 --VSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNDDRFSRVVFNEITKNAIKQA 156 Query 814 IQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK 873 ++ +N RVNAQ RR DR +GF +S L + R LSAGRVQ+ + ++ER + Sbjct 157 FEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVA-RGLSAGRVQSVAVKLLVERER 215 Query 874 E---FSESETYFLGLTLENGLQFTVEI---GKDGKEVEP---------------PEYVTV 912 E F E + + + N + + + GK+ +P +YV V Sbjct 216 EIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSDYV-V 274 Query 913 EKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 +E + P+ P+ T + + AST L +TM LAQ L+EAG Sbjct 275 TDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAG 321 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Streptomyces coelicolor A3(2)] Sequence ID: Q9X909.1 Length: 952 Range 1: 14 to 357 Score:108 bits(270), Expect:2e-22, Method:Compositional matrix adjust., Identities:109/395(28%), Positives:169/395(42%), Gaps:111/395(28%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYH- 702 L+IVESP KA+TI + G G +V E S+G++ + + + + T E Sbjct 14 LVIVESPAKAKTIKGYLGP------GYVV--EASVGHIR-DLPSGAAEVPEKYTGEVRRL 64 Query 703 GVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMREL 762 GV +++D F P+Y V+ ++K VK +++L Sbjct 65 GVDVEHD-----FQPIY------------VVNADKKS---------------QVKKLKDL 92 Query 763 AQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNE 822 +E DE+ +ATD D EGE IAW ++ VL P P +KR+ FHE+T+ AI A+ R++N+ Sbjct 93 LKESDELFLATDEDREGEAIAWHLQEVLKPKIP-VKRMVFHEITKDAIRAAVANPRELNQ 151 Query 823 GRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE---FSESE 879 V+AQ RRI DR G+E+S L + R LSAGRVQ+ ++ER +E F +E Sbjct 152 KLVDAQETRRILDRLYGYEVSPVLWKKVMPR-LSAGRVQSVATRLVVERERERIAFRSAE 210 Query 880 TYFLGLTLENGLQFTVEIGKDGKEVEPPEYV----------------------------- 910 + L T G+ G +P V Sbjct 211 YW--------DLTGTFATGRAGDASDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSANTL 262 Query 911 -------------------TVEKVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRL 951 V VE + +P P+ T + ++AS L A TM++ Sbjct 263 HLDEANARALAAALENTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKSTMQV 322 Query 952 AQDLFEAGL--------CVTPDTLVSLSDGRIMEI 978 AQ L+E G DT VS + ++ ++ Sbjct 323 AQKLYENGYITYMRTDSTTLSDTAVSAARAQVTQL 357 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Escherichia coli K-12] Sequence ID: P06612.2 Length: 865 Range 1: 4 to 395 Score:107 bits(266), Expect:6e-22, Method:Compositional matrix adjust., Identities:121/425(28%), Positives:178/425(41%), Gaps:90/425(21%) Query 643 ALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYH 702 AL+IVESP KA+TI + G D V + +S GH+ DL T+ Sbjct 4 ALVIVESPAKAKTINKYLG-------SDYV------------VKSSVGHIRDLPTSGSAA 44 Query 703 GVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVD----WEQK-GVCPRCGSTNVRDALDNVK 757 + P D +R VD WE V P G V V Sbjct 45 KKSADSTSTKTAKKPKKD--ERGALVNRMGVDPWHNWEAHYEVLP--GKEKV------VS 94 Query 758 AMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEA 817 +++LA++ D I +ATD D EGE IAW +R V+ R+ F+E+T+ AI +A + Sbjct 95 ELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP 154 Query 818 RDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEF-- 875 ++N RVNAQ RR DR +G+ +S L + R LSAGRVQ+ + ++ER +E Sbjct 155 GELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKA 213 Query 876 ---------------SESETYFLGLTLENGLQF-TVEIGKDGKEVEPPEYVTVEKVELEE 919 E L +T +N F V + V E +E E+ Sbjct 214 FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED 273 Query 920 KEFNPQP--PYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG------------------ 959 K +P P+ T + + AST L +TM +AQ L+EAG Sbjct 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN 333 Query 960 --------------LCVTPDTLVSLSDGRIMEIKEAVEGSEGNLLAVNGLKPKEAKALKF 1005 L +P+ S + + E EA+ S+ N++A LK EA A K Sbjct 334 MVRGYISDNFGKKYLPESPNQYASKENSQ--EAHEAIRPSDVNVMA-ESLKDMEADAQKL 390 Query 1006 WEIDW 1010 +++ W Sbjct 391 YQLIW 395 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P39814.1 Length: 691 Range 1: 5 to 284 Score:105 bits(261), Expect:1e-21, Method:Compositional matrix adjust., Identities:101/335(30%), Positives:161/335(48%), Gaps:75/335(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K + AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIERYLGKKYKVK-------------------ASMGHVRDLPKSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V I+ + F P Y TI+ G V +K ++ A Sbjct 44 VDIEQN-----FEPKYITIR---------------------GKGPV------LKELKTAA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ ++ +A DPD EGE IAW + + L + R+ F+E+T+ AI ++ + R +N Sbjct 72 KKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMD 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSE------ 877 V+AQ RRI DR +G+++S L + + + LSAGRVQ+ L II+R KE ++ Sbjct 132 LVDAQQARRILDRLVGYKISPILWKKVK-KGLSAGRVQSVALRLIIDREKEINDFKPEEY 190 Query 878 ----------SETYFLGLTLENGLQFTVEIGKDGKEV----EPPEYVTVEKVELEEKEFN 923 ET+ +NG + + D KE+ + +Y TVEKV +E++ N Sbjct 191 WTIDGTFLKGQETFEASFFGKNGKKLPLNSEADVKEILSQLKGNQY-TVEKVTKKERKRN 249 Query 924 PQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P P+TT + ++A+ L A +TM +AQ L+E Sbjct 250 PALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Pseudomonas aeruginosa PAO1] Sequence ID: Q9HZJ5.1 Length: 868 Range 1: 4 to 320 Score:105 bits(262), Expect:2e-21, Method:Compositional matrix adjust., Identities:98/343(29%), Positives:148/343(43%), Gaps:52/343(15%) Query 643 ALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYH 702 +L+IVESP KA+TI + G + +S GH+ DL T+ Sbjct 4 SLVIVESPAKAKTINKYLGS-------------------QYVVKSSIGHIRDLPTSGSSS 44 Query 703 GVIIQNDG-NMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDN----VK 757 G P ++ R Q V + GV P G + L + Sbjct 45 SKEPAAKGRKSASEAPALSPKEKAR---RQLVS--RMGVDPEHGWKAKYEILPGKEKVID 99 Query 758 AMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEA 817 +R LA++ D + +ATD D EGE IAW +R + KR+ F+E+T+ AI +A + Sbjct 100 ELRRLAKDADTVYLATDLDREGEAIAWHLREAIGGDESRYKRVVFNEITKKAIQEAFSQP 159 Query 818 RDVNEGRVNAQIVRRIEDRWIGFELSQEL-QRVFENRNLSAGRVQTPVLGWIIERYKEFS 876 +++ RVNAQ RR DR +G+ +S L Q++ R LSAGRVQ+ + ++ER +E Sbjct 160 GELDINRVNAQQARRFLDRVVGYMVSPLLWQKI--ARGLSAGRVQSVAVKLVVEREREIR 217 Query 877 E--SETYF---LGLTLENGLQFTVEIGKDGKEVEPP---------------EYVTVEKVE 916 E Y+ L G E+ ++ E P +V K E Sbjct 218 AFVPEEYWEVHADLGTAKGANVRFEVTREKGEAFKPLNEAQAMAALEKLKASAYSVAKRE 277 Query 917 LEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 P P+ T + + AS L +TM +AQ L+EAG Sbjct 278 DRPTSSRPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAG 320 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Sequence ID: P0A2I1.1 Length: 865 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Salmonella enterica subsp. enterica serovar Typhi] Sequence ID: P0A2I2.1 Length: 865 Range 1: 4 to 315 Score:103 bits(258), Expect:5e-21, Method:Compositional matrix adjust., Identities:107/342(31%), Positives:161/342(47%), Gaps:55/342(16%) Query 643 ALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYH 702 AL+IVESP KA+TI + G D V + +S GH+ DL T+ Sbjct 4 ALVIVESPAKAKTINKYLGN-------DYV------------VKSSVGHIRDLPTSGSAA 44 Query 703 GVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVD----WEQK-GVCPRCGSTNVRDALDNVK 757 + P D +R VD W+ V P G V V Sbjct 45 KKSADSTSTKTAKKPKKD--ERGALVNRMGVDPWHNWDAHYEVLP--GKEKV------VS 94 Query 758 AMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEA 817 +++LA++ D I +ATD D EGE IAW +R V+ R+ F+E+T+ AI +A ++ Sbjct 95 ELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQP 154 Query 818 RDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKE--- 874 ++N RVNAQ RR DR +G+ +S L + R LSAGRVQ+ + ++ER +E Sbjct 155 GELNINRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKA 213 Query 875 FSESETYFL--GLTLENG----LQFTVEIGKDGKEVEPPEYVT----VEK-----VELEE 919 F E + + T +G LQ T + K + V + + +EK +E E+ Sbjct 214 FVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLERED 273 Query 920 KEFNPQP--PYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 K + +P P+ T + + AST L +TM +AQ L+EAG Sbjct 274 KPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG 315 >RecName: Full=DNA topoisomerase I, plasmid; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Xylella fastidiosa 9a5c] Sequence ID: Q9PHK2.1 Length: 660 Range 1: 3 to 283 Score:100 bits(250), Expect:3e-20, Method:Compositional matrix adjust., Identities:94/343(27%), Positives:144/343(41%), Gaps:89/343(25%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 LMI+ESP K ++ G K I AS GH+ DL E G Sbjct 3 LMIIESPGKIEKLSTILGDGWK-------------------IAASVGHVRDLPQKE--MG 41 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V + F P Y+ +R +GV V ++ L Sbjct 42 VAAPD------FKPSYELTER------------GEGV---------------VAKLKNLL 68 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ D + +ATDPD EGE I+W ++ L P R+ F+E+T A+ ++ R ++ Sbjct 69 KQADSVYLATDPDREGEAISWHLQQCLKLSNP--LRVTFNEITANAVKASLVAPRTIDVK 126 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSESE-TYF 882 RV AQ RR+ DR +G+ +S EL R+ R LSAGRVQ+P + ++ER +E + T Sbjct 127 RVAAQEARRVLDRLVGYMVSPELSRLTGKR-LSAGRVQSPAVRLVVEREREIKAFKVTNH 185 Query 883 LGLTLENGLQFTVEIGKDG----KEVEPPEYVTVEKVELEEKEF---------------- 922 G L F + G + + P++V + +++F Sbjct 186 FGAML-----FFADAKTSGEWSAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKAVVVKSFD 240 Query 923 ------NPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 +P PP+TT M + AS L + M AQ L+E G Sbjct 241 ESEAKRSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQG 283 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292] Sequence ID: Q49X35.1 Length: 688 Range 1: 5 to 284 Score:100 bits(250), Expect:4e-20, Method:Compositional matrix adjust., Identities:97/335(29%), Positives:156/335(46%), Gaps:75/335(22%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHG 703 L+IVESP KA+TI + G+ K ++AS GH+ DL ++ G Sbjct 5 LVIVESPAKAKTIEKYLGKKYK-------------------VIASMGHVRDLPRSQ--MG 43 Query 704 VIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMRELA 763 V +ND + P Y TI+ G V VK +++ A Sbjct 44 VDAEND-----YEPKYITIR---------------------GKGPV------VKELKKHA 71 Query 764 QEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEARDVNEG 823 ++ ++ +A+DPD EGE IAW + N+L+ R+ F+E+T+ A+ + + R + Sbjct 72 KKAKKVFLASDPDREGEAIAWHLANILNLEDSTENRVVFNEITKDAVKDSFKHPRGIEME 131 Query 824 RVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYK---------- 873 V+AQ RRI DR +G+ +S L + + + LSAGRVQ+ L +I+R Sbjct 132 LVDAQQARRILDRLVGYNISPVLWKKVK-KGLSAGRVQSVALRLVIDRENEIRNFKPEEY 190 Query 874 -----EFSESETYFLG--LTLEN---GLQFTVEIGKDGKEVEPPEYVTVEKVELEEKEFN 923 EF +T F L +N L ++ K +++ ++ V KV +EK Sbjct 191 WKIEGEFRYKKTKFTAKFLHFKNKPFKLTEKADVEKITTQLDGDQF-EVTKVTKKEKTRY 249 Query 924 PQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 P P+TT + ++A+ L A +TM LAQ L+E Sbjct 250 PANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEG 284 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Vibrio cholerae O1 biovar El Tor str. N16961] Sequence ID: Q9KRB2.1 Length: 876 Range 1: 4 to 323 Score:100 bits(249), Expect:7e-20, Method:Compositional matrix adjust., Identities:100/346(29%), Positives:156/346(45%), Gaps:55/346(15%) Query 643 ALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYH 702 +L+IVESP KA+TI + G+ D + + +S GH+ DL T Sbjct 4 SLVIVESPAKAKTINKYLGK-------DFI------------VKSSVGHVRDLPTAGQTA 44 Query 703 GVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDN----VKA 758 + K D ++ R+ + ++ GV P G L V Sbjct 45 TPTGKAAAASTKKASTTDKEQQKRE-KERAALIKKMGVDPYHGWQANYQILPGKEKVVAE 103 Query 759 MRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQEAR 818 +++LA++ D + +ATD D EGE IAW +R ++ KR+ F+E+T+ AI +A ++ Sbjct 104 LQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPG 163 Query 819 DVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEF--- 875 ++N VNAQ RR DR +GF +S L + R LSAGRVQ+ + ++ER +E Sbjct 164 ELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVA-RGLSAGRVQSVAVKLLVEREREIKAF 222 Query 876 --------------SESETYFLGLTLENGLQFTVEIGKDGKEVEPPEYVT--------VE 913 ++ + + L + ++GL F K E E V V Sbjct 223 VPEEFWDINADTLTADKQDFRLLVAQKDGLAF-----KPVNETEALAAVAALNKAQYEVC 277 Query 914 KVELEEKEFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 K E + P P+ T + + AST L +TM LAQ L+EAG Sbjct 278 KREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAG 323 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycoplasmoides gallisepticum str. R(low)] Sequence ID: Q9JN65.2 Length: 719 Range 1: 6 to 336 Score:95.1 bits(235), Expect:2e-18, Method:Compositional matrix adjust., Identities:101/371(27%), Positives:172/371(46%), Gaps:78/371(21%) Query 642 SALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNE-G 700 S ++++ESPNK +TI + YE I+A+ GH+ DL G Sbjct 6 SKILVIESPNKVKTIKKYLTDD----------YE---------IVATVGHIRDLPKYTLG 46 Query 701 YHGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDN----V 756 + N F+P ++ I+ + KGV + V+ A+ N + Sbjct 47 F---------NTEDFVPKWEIIQEKKPA---------KGVSATKKAKTVKKAVKNKKEII 88 Query 757 KAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNI---KRIEFHEVTRPAIMKA 813 + + A++ DEI +ATDPD EGE I+W + +VL N+ KRI F+E++ A+ A Sbjct 89 DELVDKAKKADEIYLATDPDREGEAISWHVYDVLKEKGVNVNKCKRIIFNEISEKAVKNA 148 Query 814 IQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIER-- 871 I R++ + V++QI RR DR IGF+LS ++ SAGRVQ+ L +I ER Sbjct 149 IANPREIQKDWVSSQITRRRLDRLIGFKLSSLMKSKINAD--SAGRVQSIALKFITEREE 206 Query 872 -YKEFSESETYFLGLTLENGLQFTV---------EIG-KDGKEVEPPEYVTVEKVELEEK 920 +F + L + L++G + + ++G K+ +EV ++ T E EL ++ Sbjct 207 LINKFVPRFWWTLDVILKDGTELMLRKIDEKLKDKLGFKELEEVSGIDFNTKEDAELVKQ 266 Query 921 EFN-----------------PQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVT 963 + P+ Y T + +DA LK + + +AQ+L+E G+ + Sbjct 267 HLSDKYRVYAIDTPKLKSSYPKEVYKTSTLQQDAINKLKWRSMKITSVAQELYE-GVTID 325 Query 964 PDTLVSLSDGR 974 + + +S R Sbjct 326 DEQIALISYPR 336 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Buchnera aphidicola str. APS (Acyrthosiphon pisum)] Sequence ID: P57371.1 Length: 861 Range 1: 1 to 344 Score:92.8 bits(229), Expect:1e-17, Method:Compositional matrix adjust., Identities:100/374(27%), Positives:171/374(45%), Gaps:55/374(14%) Query 640 VKSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNE 699 ++ +L+IVESP KA+TI + G + +S GH+ DL + Sbjct 1 MQKSLVIVESPAKAKTINQYLGSE-------------------YIVKSSIGHIRDLTKGK 41 Query 700 GYHGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDN---- 755 Y N KF+ + I++ + + +Q G+ P L Sbjct 42 LY------NKEKNKKFLNE-NFIEKTNE---NKILIKQMGIDPYQNWKFEYHILPGKEKI 91 Query 756 VKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAIMKAIQ 815 + ++ +A +V I +ATD D EGE IAW ++ V+ + R+ F+E+T+ +I KA + Sbjct 92 ISELKYIANQVKHIYLATDLDREGEAIAWHLKEVIGGDSSKFSRVVFNEITQHSIQKAFK 151 Query 816 EARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIER---Y 872 +N RV+AQ RR DR +G+ +S L + R LSAGRVQ+ + I +R Sbjct 152 NVGHINMNRVHAQQARRFMDRIVGYMISPLLWKKIA-RGLSAGRVQSVAVRIIADRESII 210 Query 873 KEFSESETYFLGLTL--ENGLQFTVEIGK-DGKEVEPPE----YVTVEKVE--------L 917 K F E + L ++L ++ + +++ + K+ P VEK++ Sbjct 211 KNFVPEEYWKLDVSLISQDKKKINMDVTHYNNKKFRPINENEVSFAVEKIQKSSCIVKNY 270 Query 918 EEK--EFNPQPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVS-LSDGR 974 EEK P+ T + + AS L S +TM LAQ L+E G T + LS+ Sbjct 271 EEKISYLKAPAPFITSTLQQSASLRLGFSVKKTMFLAQKLYEEGYITYMRTDSNYLSEYA 330 Query 975 IMEIKEAVEGSEGN 988 I ++++ ++ + G+ Sbjct 331 IKKVRKYIKSNYGS 344 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Buchnera aphidicola str. Sg (Schizaphis graminum)] Sequence ID: Q8K9P7.1 Length: 853 Range 1: 4 to 309 Score:91.7 bits(226), Expect:3e-17, Method:Compositional matrix adjust., Identities:96/356(27%), Positives:156/356(43%), Gaps:89/356(25%) Query 643 ALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDL------- 695 +L+IVESP KA+TI+ + G+ + +S GH+ DL Sbjct 4 SLVIVESPVKAKTISKYLGK-------------------QYIVKSSVGHVRDLINNKSKN 44 Query 696 -------VTNEGYHGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQK-GVCPRCGST 747 +IQ G + + +W+ + + P G Sbjct 45 KKNIKKSNIKHNEKTALIQQMG------------------INPYKNWKAEYHILP--GKE 84 Query 748 NVRDALDNVKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTR 807 + L N+ A +V I +ATD D EGE IAW ++ V+ + +R+ F+E+T+ Sbjct 85 KIISELKNI------ANKVHYIYLATDLDREGEAIAWHLKEVIGGNSLKFRRVVFNEITK 138 Query 808 PAIMKAIQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGW 867 +I KA Q +N RV +Q RR DR +G+ +S L + +R LSAGRVQ+ + Sbjct 139 KSIEKAFQNIGKINMNRVYSQQARRFMDRIVGYMISPLLWKKI-SRGLSAGRVQSAAVRL 197 Query 868 IIER---YKEFSESETYFLGLTL--ENGLQFTVEIG---------KDGKEVEPPEYVTVE 913 I +R K F E E + + L+L + + T++I + KEV T+E Sbjct 198 ITDREYEIKNFIEREHWKISLSLLSKENKKVTMDITHYRNKTFLLNNKKEVNS----TIE 253 Query 914 KV--------ELEEKEFNPQP--PYTTDAMLKDASTFLKLSAPETMRLAQDLFEAG 959 K+ + ++K F +P P T + + ++ L S +TM LAQ L+E G Sbjct 254 KIKNLSFIITDRKDKIFKKKPPAPLITSTLQQASNIDLGFSVKKTMFLAQKLYEQG 309 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I [Mycolicibacterium smegmatis MC2 155] Sequence ID: A0R5D9.1 Length: 936 Range 1: 337 to 612 Score:90.1 bits(222), Expect:1e-16, Method:Compositional matrix adjust., Identities:82/287(29%), Positives:127/287(44%), Gaps:36/287(12%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYF--KPRHW-----GEEGTHEAIRPTRPID 1502 TY RTDST +S + I A+ Q GEEY PR + + HEAIRP Sbjct 337 ITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQYTRKVKNAQEAHEAIRP----- 391 Query 1503 TGRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLMERAVIDAGVGKAE- 1561 G + Q QL L + +RLY++I++R + SQM A+ I E Sbjct 392 AGDVFQTPG----QLHSALDTDEFRLYELIWQRTVASQMADARGTTLSLRIGGSASSGEQ 447 Query 1562 ---------------LEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVE--AKKWKAP 1604 L+ YVE I++ +LP L +G ++ + A + Sbjct 448 VVFNASGRTITFPGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDAADLSADGHQTS 507 Query 1605 KVQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYL 1664 Y++ +I ++E IGRPSTY+ I++T+ R YV + +G LVP+ V L Sbjct 508 PPARYTEASLIKALEELGIGRPSTYSSIIKTIQDRGYV-QKKG-SALVPSWVAFAVVGLL 565 Query 1665 VTKYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEILCGVKG 1711 + LV + T ++E+++D I G+ L + Y GV+G Sbjct 566 EQHFGRLVDYDFTAAMEDELDEIANGQEQRTNWLNNFYFGGEHGVEG 612 >RecName: Full=Elongation factor 2; Short=EF-2; Contains: RecName: Full=Mka FusA intein [Methanopyrus kandleri AV19] Sequence ID: Q8TXJ4.1 Length: 1257 Range 1: 33 to 558 Score:90.1 bits(222), Expect:1e-16, Method:Compositional matrix adjust., Identities:152/558(27%), Positives:229/558(41%), Gaps:97/558(17%) Query 959 GLCVTPDTLVSLSDGRIMEIKEAVE--GSEGNLLAV--------------------NGLK 996 G CV P+T + L+DGR + E E G L+ + ++ Sbjct 33 GKCVAPETKICLADGRFVRADELFEELKERGRLVKCDESEEVYELREPVGVSSLDKDAVE 92 Query 997 PKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMR-DGKLGWVSAKNIREGDYV 1055 E K W + + ++V ++KNG I+ TP+H LV+ G++ A + GDY+ Sbjct 93 IVEGKITHVWRLKADKLVEV-EVKNGRSIRTTPEHKFLVLDPSGEIVEKRADELEIGDYI 151 Query 1056 AFAYNTGHRGREEYTLLNLLIKLGITDVMVEVDEEYFNEKVAPIIKER------------ 1103 H G E L + + D V + EE E V + KER Sbjct 152 VCTQKLVHEGMSEEELKREVFRRLGRDFFVHLPEEE-AESVLELAKERGIKALWETLEVD 210 Query 1104 IPTSTKYKYLR----RYVLPLHLLQEWRID--DYETHVKSLYRQRAGS-KPIPNFKLDER 1156 I ++ Y LR R + + L +E +D D V+ YR S KPI E Sbjct 211 IEENSFYYQLRKGRIRADILVDLAEELGLDLADLYDAVEVSYRSNTKSTKPI-RLPEPED 269 Query 1157 FWYVFGLVLGDGT---LRNSKVLISQTPLKDVKSVLKEVFPFLYVFETTTQVGFSNS--- 1210 +Y+ GL+ GDG L N I Q +K + S + T ++ F + Sbjct 270 LFYLAGLMFGDGCWNQLTNGSEAI-QGEVKRIASDMGLEVRVRRYEGKTARIDFPETVPR 328 Query 1211 ILAEVF---RRLGAREGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNGRKGPNFRAIL 1267 IL +F RR A +++ + + I I GYFD DGT + GR + + Sbjct 329 ILEALFDYPRRKKAHRIRVNDFLTRAPLDCIAEFIRGYFDADGT--VEEGRSAVS----V 382 Query 1268 TSKRGDVLRMLSVYLYQVGIMNYLRRDERTGVWDLIISN-RSLEKFREKIYPYLRIRRRQ 1326 TS + L L + L + + +YLR E G + L +S RSLE+F P R+ Sbjct 383 TSVSREFLEDLQLLLQKFDVASYLR--EGDGAYTLYVSGARSLERF-----PGF----RE 431 Query 1327 FEEAYSVYRSSRRAFEEDLLPVASIFRKLKFRNGVKNRILKETGIDI-----WNWLKRLE 1381 E+A + + +A +L V + IL+E D+ +N E Sbjct 432 PEKAEKLKKLMEKASSSELEKVP-----------ISGEILREVRGDVPTTRMFNCYSNYE 480 Query 1382 G---EIPRSKLAKVLEYAE----EGPEKEFLKSLVEAGVTWVKVKEVEEEHYTGKLYDFT 1434 G + +S L KV+ E EG E LK+L V +++V VEE Y G +YDFT Sbjct 481 GGQVGLTKSSLEKVISTLEAVGVEGEALERLKALARDDVCFLEVVRVEEVEYDGYVYDFT 540 Query 1435 TTT-ENFLSNGAVSHNCT 1451 NF + G V HN T Sbjct 541 VEEHHNFAAEGFVVHNTT 558 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycoplasmoides pneumoniae M129] Sequence ID: P78032.1 Length: 711 Range 1: 82 to 201 Score:87.8 bits(216), Expect:5e-16, Method:Compositional matrix adjust., Identities:47/122(39%), Positives:77/122(63%), Gaps:3/122(2%) Query 754 DNVKAMRELAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPN-IKRIEFHEVTRPAIMK 812 D +K+++E A + I +ATDPD EGE I+W + +VL + +RI F+E+T+ A++ Sbjct 82 DIIKSIKEKASKATNIYLATDPDREGEAISWHVYDVLDEKDKSKCQRITFNEITKNAVLD 141 Query 813 AIQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERY 872 A++ R++++ V +Q R+I DR IGF LS+ L + SAGRVQ+ L ++ ER Sbjct 142 ALKNPREIDQSWVQSQFARQILDRMIGFRLSRLLNNYLSAK--SAGRVQSVALRFLEERE 199 Query 873 KE 874 +E Sbjct 200 QE 201 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycoplasmoides genitalium G37] Sequence ID: P47368.1 Length: 709 Range 1: 5 to 197 Score:86.7 bits(213), Expect:1e-15, Method:Compositional matrix adjust., Identities:65/236(28%), Positives:118/236(50%), Gaps:45/236(19%) Query 644 LMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLV-TNEGYH 702 L+++ESPNK +T+ + PS I+++ GH+ ++V N G+ Sbjct 5 LVVIESPNKVKTLKQYL--PSDE----------------FEIVSTVGHIREMVYKNFGF- 45 Query 703 GVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVKAMREL 762 D N + P+++ DW + ++ + +K+++ Sbjct 46 ------DENT--YTPIWE-------------DWTKNKQKNP-KQKHLLSKFEIIKSIKAK 83 Query 763 AQEVDEILIATDPDTEGEKIAWDIRNVLSPY-TPNIKRIEFHEVTRPAIMKAIQEARDVN 821 A + I +A+DPD EGE I+W + ++L KRI F+E+T+ A++ A+++ R+++ Sbjct 84 ASDAQNIFLASDPDREGEAISWHVYDLLDQKDKAKCKRITFNEITKKAVVDALKQPRNID 143 Query 822 EGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFSE 877 V +Q R+I DR IGF LS+ L + + SAGRVQ+ L ++ ER KE ++ Sbjct 144 LNWVESQFARQILDRMIGFRLSRLLNSYLQAK--SAGRVQSVALRFLEEREKEIAK 197 >RecName: Full=DNA topoisomerase 1 type prokaryotic [Acanthamoeba polyphaga mimivirus] Sequence ID: Q5UQB5.1 Length: 854 Range 1: 300 to 606 Score:83.6 bits(205), Expect:9e-15, Method:Compositional matrix adjust., Identities:78/318(25%), Positives:142/318(44%), Gaps:73/318(22%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYF-----KPRHWGEEGTHEAIRPTRPIDTG 1504 TY RTDS +S G K+ IT + G +Y+ K + + HEAIRPT P Sbjct 300 ITYMRTDSVEISAEGHRDIKKIITDQYGADYYQKNLYKNKAANSQEAHEAIRPTHP---- 355 Query 1505 RLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLME--------------- 1549 L+ L +G I+ + +LY +I++R + SQMK AK+ + Sbjct 356 ELLTL--EGEIEDAYQI-----KLYKLIWQRTIASQMKPAKIKVTIIQISISKYVEDKLN 408 Query 1550 -----RAVIDAGVGKAELEGYVEIIEDGWTKLR-SPNFR-QLPRLKEGAKLKVVEAKKWK 1602 ++ I+ V ++ YVE I+D T + + NF ++P + ++ + A++ Sbjct 409 PFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKNFTGKIPTVGSKVTMEEIIARQEY 468 Query 1603 APKVQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFET----------------- 1645 YS+ ++ ++E IGRPSTY ++T++ R YV T Sbjct 469 MRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINREYVKITDVPGIKKDITIYSIKSE 528 Query 1646 ------------------RGRKKLVPTDKGIKVYHYLVTKYKDLVSEEKTRSLEEKMDLI 1687 + KK+VPT+ GI V +L+ + + + + T ++E +D + Sbjct 529 NKKHIMEVYEDTDTILLGKENKKIVPTNLGITVNDFLMKYFPEFLDYKFTANMETDLDYV 588 Query 1688 EEGKLDYLKVLYDLYNEI 1705 G +++ ++ D Y+++ Sbjct 589 STGTKNWVDIVQDFYDKL 606 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Mycobacterium leprae TN] Sequence ID: O69548.1 Length: 947 Range 1: 342 to 606 Score:82.8 bits(203), Expect:2e-14, Method:Compositional matrix adjust., Identities:78/277(28%), Positives:126/277(45%), Gaps:37/277(13%) Query 1451 TYHRTDSTHVSNTGIEVAKEYITQEVGEEYF--KPRHW-----GEEGTHEAIRPTRPIDT 1503 TY RTDST +S + I A+ Q GEEY PR + + HEAIRP Sbjct 342 TYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRP-----A 396 Query 1504 GRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAAKLLM----------ERAVI 1553 G D + L + +R+Y++++RR + SQM A+ E+ V+ Sbjct 397 GETFA-TPDAVCN---ELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVV 452 Query 1554 DAGVGKAE-----LEGYVEIIEDGWTKLRSPNFRQLPRLKEGAKLKVVEAKK---WKAPK 1605 + G+ L+ YVE +++ R+LP L G L V++ P Sbjct 453 FSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPP 512 Query 1606 VQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYLV 1665 + Y++ ++ ++E IGRPSTY+ I++T+ R YV + +G LVP+ V L Sbjct 513 AR-YTEASLVKALEELGIGRPSTYSSIIKTVQDRGYV-QKKG-SALVPSWVAFAVTGLLE 569 Query 1666 TKYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLY 1702 + LV + T ++E+++D I G L + Y Sbjct 570 QHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFY 606 >RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Swivelase; AltName: Full=Untwisting enzyme [Borreliella burgdorferi B31] Sequence ID: O51768.1 Length: 848 Range 1: 322 to 578 Score:82.8 bits(203), Expect:2e-14, Method:Compositional matrix adjust., Identities:83/288(29%), Positives:131/288(45%), Gaps:56/288(19%) Query 1450 CTYHRTDSTHVSNTGIEVAKEYITQEVGEEYF--KPRHWGEE----GTHEAIRPTRPIDT 1503 TY RTDS +++ + + I + G+EY K R + +E HEAIRP+ Sbjct 322 ITYMRTDSHNIAKIAKDKITKIIKNKYGKEYIEEKDRIYEKEKMAQNAHEAIRPSEIFIP 381 Query 1504 GRLMQLVRDGIIQLPKNLTRNHYRLYDMIFRRFMTSQMKAA-----------KLLMERAV 1552 +++ ++ +Y +I+ R + S MK A K L+ R+ Sbjct 382 NETIEIE-----------SKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFRS- 429 Query 1553 IDAGVGKAELEGYVEIIEDGWTKLRSPNFRQL----PRLKEGAKLKVVEAK----KWKAP 1604 + +II DG+ K L +K+G +V+ K + KAP Sbjct 430 -----------SFTKIIFDGFLKHTKEQDEHLNINFDLIKKGDTFSIVKMKTSEHETKAP 478 Query 1605 KVQLYSQGDIIAMMKERKIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTDKGIKVYHYL 1664 Y++ ++ M++ IGRPSTY+ I+ TLL+R Y F+ L+PT KG V + L Sbjct 479 --FRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNT--LMPTIKGAAVINLL 534 Query 1665 VTKYKDLVSEEKTRSLEEKMDLIEEGKLDYLKVLYDLYNEILCGVKGI 1712 + L+ T ++EEK+D I GKLD +K L YN G KG+ Sbjct 535 EKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYN----GKKGL 578 >RecName: Full=Probable translation initiation factor IF-2; Contains: RecName: Full=Pko infB intein; AltName: Full=Pko IF2 intein [Thermococcus kodakarensis KOD1] Sequence ID: Q5JGR9.1 Length: 1144 Range 1: 82 to 591 Score:80.9 bits(198), Expect:8e-14, Method:Compositional matrix adjust., Identities:139/537(26%), Positives:224/537(41%), Gaps:92/537(17%) Query 1006 WEIDWNGPLKVIKLKNGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVAFAYNTGHRG 1065 W++ G + +KLKN H + TP+H L R GWV A ++ GDYVA Sbjct 82 WKVRHRGKMLRVKLKNWHSVSVTPEHPFLTTR----GWVRADQLKPGDYVAVPRVIHGNE 137 Query 1066 REEYTLLNLLIKLGITDVMVEVDEEYFNEKVAPIIKERIPTSTKYKYLRRYVLPLHLLQE 1125 +E + + KL +++ ++ E ++ I YK + R V ++ Sbjct 138 SDERFVSFVYEKLKNDELIAKLRGEVLSK-----ISSEFKGDRAYK-VERNVFRWEDIER 191 Query 1126 WRIDDYETHVKSLYRQRAGSKPIPNFKLD------ERFWYVFGLVLGDGT---LRNSKVL 1176 + D V R KP+ KL E F+Y G++ GDG+ + N+ V Sbjct 192 LNLWDEVERVAFTPRMHRSGKPLHYVKLPRSPEEWEAFFYFAGVMFGDGSQDKIANNDVE 251 Query 1177 ISQTPLKDVKSVLKEVFPFLYVFETTT-QVGFSNS---------ILAEVFRRLGAREGKL 1226 + + LK + SVL V TT+ ++ +N +L E R A+ ++ Sbjct 252 VYEE-LKKL-SVLG--VAVKRVERTTSYEIELTNGKNALLRLLRVLFEYPERQKAKSIRV 307 Query 1227 HPLVFGLREEYINAMIAGYFDTDGTFSILNGRKGPNFRAILTSKRGDVLRMLSVYLYQVG 1286 ++F +Y++ + GYFD DG S+ + R +TS + L LS+ L + G Sbjct 308 PRILFIAPRKYVSRFLRGYFDADGHVSLKDA------RIEVTSASQEFLEDLSLLLLRFG 361 Query 1287 IMNYLRRDERTGVWDLIISNRSLEKFR-----------EKIYPYLRIRRRQ-----FEEA 1330 I++ + R + T + +I R+L+ FR E + ++ RR FEE Sbjct 362 IVSKIYRSDYTTL--VISGRRNLDLFRRYIGFSVKNKAEALEKAIKKSRRSESYPIFEEL 419 Query 1331 --------------------YSVYRSSRRAFEEDLLPVASIFRKLKFRNGVKNRILKETG 1370 Y Y S E L+ + K K +L E Sbjct 420 KRLRLLFGFTRTELNSNVPFYGKYESEEAPSYETLMRILDAIEKGSINLDKKIAVL-EGR 478 Query 1371 IDIWNWLKRLE--GEIPRSKLAKV-LEYAEEGPEKEFLKSLVE------AGVTWVKVKEV 1421 I N++K E G I KL ++ E E +EF S V+ + ++ V+++ Sbjct 479 IRDHNYIKAFEKDGLIKDGKLTELGRELLEVWRNREFDSSDVDYIRNLAENLVFIPVEDI 538 Query 1422 EEEHYTGKLYDFTTTTENFLSNGAVSHNCT-YHRTDSTHVSNTGIEVAKEYITQEVG 1477 EE Y G +YD TT T NF++NG + HN T R T+V+ G E ITQ +G Sbjct 539 EEFEYEGYVYDVTTETHNFVANGILVHNTTLLDRIRHTNVA--GKEAGG--ITQHIG 591 >RecName: Full=Probable translation initiation factor IF-2; Contains: RecName: Full=Pho infB intein; AltName: Full=Pho IF2 intein [Pyrococcus horikoshii OT3] Sequence ID: O58822.1 Length: 1044 Range 1: 84 to 491 Score:68.9 bits(167), Expect:3e-10, Method:Compositional matrix adjust., Identities:120/519(23%), Positives:196/519(37%), Gaps:158/519(30%) Query 1006 WEIDWNGPLKVIKLKNGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVAFAYNTGHRG 1065 W++ + G + +KLK+ H + TP+H L R GWV A ++ GDYVA + Sbjct 84 WKVRYKGKMLRVKLKDWHSVAVTPEHPFLTTR----GWVRADQLKPGDYVAVPKILPGKD 139 Query 1066 REEYTLLNLLIKLGITDVMVEVDEEYFNEKVAPIIKERIPTSTKYKYLRRYVLPLHLLQE 1125 +E L +Y +EK+ + ++P+S +E Sbjct 140 DKEKFL------------------QYVHEKLKGKVHIKLPSSD---------------EE 166 Query 1126 WRIDDYETHVKSLYRQRAGSKPIPNFKLDERFWYVFGLVLGDGTLRNSKVLISQTPLKDV 1185 W E F+Y G + G N + L + V Sbjct 167 W----------------------------ETFFYFAGTIFGRENSVNPEGLTHE-----V 193 Query 1186 KSVLKEVFPFLYVFETTTQVGFSNSILAEVFRRLGAREGKLHPLVFGLREEYINAMIAGY 1245 K++L E+F L+ + EV R ++F Y+ + G+ Sbjct 194 KALL-ELFKVLFEYPR------------EVLR-----------VLFMAPVRYVANFLRGF 229 Query 1246 FDTDGTFSILNGRKGPNFRAILTSKRGDVLRMLSVYLYQVGIMNYLRRDERTGVWDLIIS 1305 FD +G + G R + +VL LS+ L ++GI++ + I Sbjct 230 FDINGYVN------GEELRVEVRGAPHEVLEELSLILLRLGIVSKIYPTSLA-----ISG 278 Query 1306 NRSLEKFREKIYPYLR---------IRRRQFEEAYSVYRSSRRA------FEEDLLPVAS 1350 R+LE FR I + IRR + E+Y ++ RR +L Sbjct 279 RRNLELFRRYIGFSEKQKAKELEGIIRRSENSESYPIFEELRRIRLLFGFTRAELSSTIP 338 Query 1351 IFRKLKFRNGVKNRIL-------KETGIDIWNWLKRLEG---------EIPRSKLAKVLE 1394 ++ K + + IL ++ D+ + LEG E R L K + Sbjct 339 LYSKYESKEAPSYEILMKILNTIEKGSKDLNKKITILEGRVRDHEYIEEFKREGLIKDGK 398 Query 1395 YAEEGPE-------KEF-------LKSLVEAGVTWVKVKEVEEEHYTGKLYDFTTTTENF 1440 E G E +EF L++++E V ++ V+++EE Y G +YD TT T NF Sbjct 399 LTELGKELLEVWRNREFDSRDVNYLRNIIENFV-FLPVEKIEEFEYDGYVYDVTTETHNF 457 Query 1441 LSNGAVSHNCTYHRTDSTHVSNTGIEVAKEY--ITQEVG 1477 ++NG + HN T D +N AKE ITQ +G Sbjct 458 IANGILVHNTTL--LDKIRKTNVA---AKEAGGITQHIG 491 >RecName: Full=Probable translation initiation factor IF-2; Contains: RecName: Full=Mja infB intein; AltName: Full=Mja IF2 intein [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q57710.1 Length: 1155 Range 1: 48 to 578 Score:67.4 bits(163), Expect:1e-09, Method:Compositional matrix adjust., Identities:132/574(23%), Positives:238/574(41%), Gaps:118/574(20%) Query 953 QDLFEAGLCVTPDTLVSLSDGRIMEIKEAVEGSEGNLLAVNGLKPKEAKALKFWEIDWNG 1012 +DLF+ G + L + R + IK G + +N A W++ G Sbjct 48 EDLFKIGKEIVEKD--ELKEIRKLNIKVHTLNENGEIKIIN--------APYVWKLKHKG 97 Query 1013 PLKVIKLKNGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVAFAYNTGHRGREEYTLL 1072 + +KLKN H I TP+H L GW+ A+NI++G YVA G E++ Sbjct 98 KMIKVKLKNWHSITTTPEHPFLTNN----GWIKAENIKKGMYVAIPRKI--YGNEDFEKF 151 Query 1073 NLLI--KLGITDVMVEVDEEYFNEKVAPIIKERIPTSTKYKYLRRYVLPLHLLQEWRIDD 1130 I K+ +++V+V+E+ +P++ YK + ++ + I + Sbjct 152 IEFINSKILTNELIVKVNEKDLKNV-------ELPSTKIYKKQK------NVFRSEDIIE 198 Query 1131 YETHVKSLY---RQRAGSKPIPNFKLDERF------WYVFGLVLGDGTL----RNSKVLI 1177 + +++ + R KP KL + +Y G++ GDG + N + + Sbjct 199 HNLNIEKISFSPRIHRCGKPQHYIKLPKSLNEWKAIFYFAGVMFGDGCVDRIANNDEEVF 258 Query 1178 SQTPLKDVKSVLKEVFPFLYVFETTTQVGFSNS---------ILAEVFRRLGAREGKLHP 1228 ++ LK + ++ EV +++ ++ F N IL + + K+ Sbjct 259 NK--LKSLNNLGIEVERIKR--KSSYEIIFKNGKNALINLLKILFDYPSEKKSHNIKIPQ 314 Query 1229 LVFGLREEYINAMIAGYFDTDGTFSILNGRKGPNFRAILTSKRGDVLRMLSVYLYQVGIM 1288 +++ +E + I GYFD DG ++ R I SK + + LS+ L + I Sbjct 315 ILYIAPKELVAEFIKGYFDADGYVNLRQNR----IEVISASK--EFIEGLSILLLRFEIT 368 Query 1289 NYLRRDERTGVWDL-------IISNRSLEKFR----------EKIYPYLRIRRRQFEEAY 1331 + + +++ I+ R+L+ F+ E + + R+ E Y Sbjct 369 SKIYEIKKSYKETKKKYYQLNIVGKRNLKNFKNIGFSIKYKEENLNKIIEKSRKS--EKY 426 Query 1332 SVYRSSRR-----------------AFEEDLLPVASIFRKLKFRNGVKNR-------ILK 1367 + + +R A E+ + S KF N +K + +L+ Sbjct 427 PINKDMKRLRILFGMTRNEVNVSYYAKYENGKEIPSYEIVKKFLNSLKPKNLDKKIKVLE 486 Query 1368 ETGIDIWNWLKRLE--GEIPRSKLAKVLEYA-------EEGPEK-EFLKSLVEAGVTWVK 1417 D+ N+LK E G I +L K+ A E G E +++KSL+E + +V+ Sbjct 487 GKERDV-NYLKAFESDGLIENGRLTKLGREALNIWKNHEFGKENIDYMKSLIE-NIAFVE 544 Query 1418 VKEVEEEHYTGKLYDFTTTTENFLSNGAVSHNCT 1451 V++VE Y G +YD TT T NF++NG V HN T Sbjct 545 VEDVEIIDYDGYVYDLTTETHNFIANGIVVHNTT 578 >RecName: Full=Replicative DNA helicase DnaB; AltName: Full=DNA 5'-3' helicase DnaB; Contains: RecName: Full=Homing endonuclease PI-Rma43812IP; AltName: Full=Rma DnaB intein [Rhodothermus marinus] Sequence ID: O30477.1 Length: 941 Range 1: 416 to 856 Score:55.1 bits(131), Expect:6e-06, Method:Compositional matrix adjust., Identities:117/522(22%), Positives:199/522(38%), Gaps:100/522(19%) Query 954 DLFEAGLCVTPDTLVSLSDGRIMEIKEAVEGSEGNLLAVNGLKPKEAKALKFWEIDWNG- 1012 DL E+G C+ DTL++L+DGR + I+E V ++ A+N + +A + G Sbjct 416 DLRESG-CLAGDTLITLADGRRVPIRELVSQQNFSVWALNPQTYRLERA-RVSRAFCTGI 473 Query 1013 -PLKVIKLKNGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVAF-----AYNTGHRGR 1066 P+ + + G I+AT +H L + GW ++ GDY+A +T Sbjct 474 KPVYRLTTRLGRSIRATANHRFLTPQ----GWKRVDELQPGDYLALPRRIPTASTPTLTE 529 Query 1067 EEYTLLNLLIKLGITDVMVEVDEEYFNEKVAPIIKERIPTSTKYKYLRRYVLPLHLLQ-E 1125 E LL LI G T LP H++Q Sbjct 530 AELALLGHLIGDGCT------------------------------------LPHHVIQYT 553 Query 1126 WRIDDYETHVKSLYRQRAGSKPIPNFKLDERFWYVFGLVLGDGTLRNSKVLIS--QTPLK 1183 R D T V L + GSK P + + R++ V+ LR ++ L + P+ Sbjct 554 SRDADLATLVAHLATKVFGSKVTPQIRKELRWYQVY--------LRAARPLAPGKRNPIS 605 Query 1184 DVKSVLKEVFPFLYVFETTTQVGFSNSILAEVFRRLGAREGKLHPLVFGLREEYINAMIA 1243 D L+++ F L + E K+ L+F E I + Sbjct 606 D---WLRDLGIF----------------------GLRSYEKKVPALLFCQTSEAIATFLR 640 Query 1244 GYFDTDGTFSILNGRKGPNFRAILTSKRGDVLRMLSVYLYQVGIMNYLR---RDERTGV- 1299 + TDG + G+K P + + R + L ++GI L+ + E+ V Sbjct 641 HLWATDGCIQMRRGKK-PYPAVYYATSSYQLARDVQSLLLRLGINARLKTVAQGEKGRVQ 699 Query 1300 WDLIISNR-SLEKFREKIYPYLRIRRRQFEEAYSVYRSSRRAFEEDLLPVA---SIFRKL 1355 + + +S R L +F EKI +R Y D++PVA + R+ Sbjct 700 YHVKVSGREDLLRFVEKIGAVGARQRAALASVYDYLSVRTGNPNRDIIPVALWYELVREA 759 Query 1356 KFRNGVKNRILKETGIDIWNWLKRLEGEIPRSKLAKVLEYAEEGPEKEFLKSLVEAGVTW 1415 ++ G+ +R L + + + A L A PE L+ L ++ V W Sbjct 760 MYQRGISHRQLHANLGMAYGGMTLFRQNL-SRARALRLAEAAACPE---LRQLAQSDVYW 815 Query 1416 VKVKEVEEEHYTGKLYDFTTT-TENFLSNGAVSHNCTYHRTD 1456 + +E + +++D T NF++N ++HN D Sbjct 816 DPIVSIEPDGVE-EVFDLTVPGPHNFVANDIIAHNSIEQDAD 856 >RecName: Full=Probable translation initiation factor IF-2; Contains: RecName: Full=Pab infB intein; AltName: Full=Pab IF2 intein [Pyrococcus abyssi GE5] Sequence ID: Q9UZK7.1 Length: 992 Range 1: 369 to 439 Score:50.8 bits(120), Expect:1e-04, Method:Compositional matrix adjust., Identities:30/78(38%), Positives:47/78(60%), Gaps:10/78(12%) Query 1403 EFLKSLVEAGVTWVKVKEVEEEHYTGKLYDFTTTTENFLSNGAVSHNCT-YHRTDSTHVS 1461 ++++++ E + ++ V+ VEEE Y G +YD TT T NF++NG + HN T R T+V+ Sbjct 369 DYIRNIAET-LVFIPVENVEEEEYDGYVYDLTTETHNFIANGILVHNTTLLDRIRKTNVA 427 Query 1462 NTGIEVAKEY--ITQEVG 1477 AKE ITQ +G Sbjct 428 ------AKEAGGITQHIG 439 Range 2: 19 to 128 Score:46.6 bits(109), Expect:0.002, Method:Compositional matrix adjust., Identities:34/114(30%), Positives:50/114(43%), Gaps:20/114(17%) Query 959 GLCVTPDTLVSLSDGRIMEIKEAVEGS---------------EGNLLAVNG-LKPKEAKA 1002 G C+ PD V + + +KE E + + + +VNG K KA Sbjct 19 GKCLLPDEKVVVPSVGFVTLKELFETASKVVERDDEKEIRELDERITSVNGDGKTGLVKA 78 Query 1003 LKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMRDGKLGWVSAKNIREGDYVA 1056 W++ G + +KLKN H + TP+H L + GW A +R GDYVA Sbjct 79 SYVWKVRHKGKVIRVKLKNWHGVTVTPEHPFLTTK----GWKRADQLRPGDYVA 128 >RecName: Full=DNA topoisomerase 3-beta [Oryza sativa Japonica Group] Sequence ID: Q0J0S6.1 Length: 866 Range 1: 1 to 332 Score:48.1 bits(113), Expect:8e-04, Method:Compositional matrix adjust., Identities:87/368(24%), Positives:139/368(37%), Gaps:76/368(20%) Query 639 LVKSALMIVESPNKARTIANFF-GQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVT 697 + + LM+ E P+ A +IA+ G TR G +E + G H F VT Sbjct 1 MAPTVLMVAEKPSIALSIASALSGGRMSTRKGSTDVHE-------FDGMFQGSHAFFKVT 53 Query 698 NEGYHGVIIQNDGNMLKFIPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSTNVRDALDNVK 757 + H + + F P Y +WE + +R N K Sbjct 54 SVIGHVLSVD-------FPPAYQ-------------NWEGTDPMDLFVAPVLRSEC-NPK 92 Query 758 AM--RELAQE---VDEILIATDPDTEGEKIAWDIRNVL----SPYTPNIKRIEFHEVTRP 808 A R LAQE +++ D D EGE I +++ + S I R +F VT Sbjct 93 AHIRRHLAQEARGCTYLVLWLDCDREGENICYEVIDCTGIPKSEVGRRIFRAKFSSVTEK 152 Query 809 AIMKAIQEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFE-------NRNLSAGRVQ 861 IM A+ ++ A R+ D +G ++ R F+ +R +S G Q Sbjct 153 DIMDAMNNLVLPSKDEALAVDARQEIDLKVGVAFTRFQTRYFQGKYGNLDSRVISYGPCQ 212 Query 862 TPVLGWIIERYKE--------FSESETYFLG--------------LTLENGLQFTVEIGK 899 TP LG+ ++RY++ F +TY + + + F + Sbjct 213 TPTLGFCVQRYQQITTFKPEKFWSLKTYVIKDGNEIQLEWDRKKLFDFDVTVMFQKMVAS 272 Query 900 DGKEVEPPEYVTVEKVELEEKEFNPQPP-YTTDAMLKDASTFLKLSAPETMRLAQDLFEA 958 DG + V + ++E E +PP T +LK AS+ L + M LA+ L+ Sbjct 273 DG-------ILKVTDISVKE-ECKARPPGLNTVNLLKVASSALGIGPQTAMHLAERLYTQ 324 Query 959 GLCVTPDT 966 G P T Sbjct 325 GFISYPRT 332