P22897.1/1-1456Q61830.2/1-1456Q64449.3/1-1479Q4TU93.1/1-1480Q9UBG0.2/1-1479P49259.1/1-1463Q62028.1/1-1487Q5R880.2/1-1464Q13018.2/1-1463P49260.1/1-1458Q920P9.1/1-1722Q60767.2/1-1723O60449.3/1-1722ConservationQualityConsensusOccupancy
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*20000-------01--66**8241-2073-------6--302224234*7*5425434*95753-3446634*4330326599***633+9492543***74--454223394993**6420476*5*552----6+35543202010-------65473-+0442423*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