hmmsearch - search a sequence database with a profile HMM HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: profile2 [nadya_filtered] Sequence database: /srv/databases/emboss/data/uniprot/uniprot_sprot.fasta per-sequence score cutoff: >= 50.0 per-domain score cutoff: [none] per-sequence Eval cutoff: <= 1e+04 per-domain Eval cutoff: [none] - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query HMM: nadya_filtered Accession: [none] Description: [none] [HMM has been calibrated; E-values are empirical estimates] Scores for complete sequences (score includes all domains): Sequence Description Score E-value N -------- ----------- ----- ------- --- ILRL2_HUMAN Q9HB29 Interleukin-1 receptor-like 2 (IL- 298.0 1.1e-84 1 ILRL1_MOUSE P14719 Interleukin-1 receptor-like 1 (Int 296.3 3.5e-84 1 ILRL2_MOUSE Q9ERS7 Interleukin-1 receptor-like 2 (IL- 294.8 1e-83 1 ILRL1_HUMAN Q01638 Interleukin-1 receptor-like 1 (Pro 289.5 3.9e-82 1 ILRL2_RAT Q62929 Interleukin-1 receptor-like 2 (IL- 287.3 1.8e-81 1 ILRL1_RAT Q62611 Interleukin-1 receptor-like 1 (Fit 282.6 4.7e-80 1 IL18R_MOUSE Q61098 Interleukin-18 receptor 1 (IL-18R- 268.8 6.7e-76 1 IL1R1_RAT Q02955 Interleukin-1 receptor type 1 (IL- 260.8 1.8e-73 1 TLR4_PIG Q68Y56 Toll-like receptor 4 (CD284) (Prec 253.6 2.6e-71 1 TLR4_MOUSE Q9QUK6 Toll-like receptor 4 (CD284) (Prec 253.0 3.9e-71 1 TLR5_HUMAN O60602 Toll-like receptor 5 (Toll/interle 252.0 7.6e-71 1 IL1AP_RAT Q63621 Interleukin-1 receptor accessory p 251.9 8.1e-71 1 IL1AP_MOUSE Q61730 Interleukin-1 receptor accessory p 251.1 1.5e-70 1 IL1AP_MACMU P59822 Interleukin-1 receptor accessory p 248.5 9e-70 1 IL1R1_MOUSE P13504 Interleukin-1 receptor type 1 (IL- 247.8 1.4e-69 1 IL1AP_HUMAN Q9NPH3 Interleukin-1 receptor accessory p 247.7 1.5e-69 1 TLR4_BOSTR Q2V898 Toll-like receptor 4 (CD284) (Prec 247.2 2.2e-69 1 TLR4_BOVIN Q9GL65 Toll-like receptor 4 (CD284) (Prec 247.2 2.2e-69 1 I18RA_HUMAN O95256 Interleukin-18 receptor accessory 244.3 1.6e-68 1 TLR4_HORSE Q9MYW3 Toll-like receptor 4 (CD284) (Prec 243.9 2.1e-68 1 TLR4_RAT Q9QX05 Toll-like receptor 4 (Toll4) (CD28 243.9 2.1e-68 1 TLR4_CRIGR Q9WV82 Toll-like receptor 4 (CD284) (Prec 243.3 3.2e-68 1 TLR5_MOUSE Q9JLF7 Toll-like receptor 5 (Precursor) 241.8 8.9e-68 1 IL18R_HUMAN Q13478 Interleukin-18 receptor 1 (IL-18R- 232.8 4.6e-65 1 TLR4_GORGO Q8SPE8 Toll-like receptor 4 (CD284) (Prec 232.7 4.9e-65 1 TLR4_HUMAN O00206 Toll-like receptor 4 (hToll) (CD28 232.7 4.9e-65 1 TLR4_FELCA P58727 Toll-like receptor 4 (CD284) (Prec 232.4 6.1e-65 1 TLR4_PANPA Q9TTN0 Toll-like receptor 4 (CD284) (Prec 232.4 6.1e-65 1 IL1R1_HUMAN P14778 Interleukin-1 receptor type 1 (IL- 232.4 6.2e-65 1 TLR4_PAPAN Q9TSP2 Toll-like receptor 4 (CD284) (Prec 232.0 8e-65 1 TLR2_CAPHI Q0GC71 Toll-like receptor 2 (CD282) (Prec 230.3 2.6e-64 1 TLR2_CAPIB B2LT62 Toll-like receptor 2 (CD282) (Prec 230.3 2.6e-64 1 TLR8_HUMAN Q9NR97 Toll-like receptor 8 (CD288) (Prec 229.6 4.3e-64 1 TLR4_PONPY Q8SPE9 Toll-like receptor 4 (CD284) (Prec 229.4 4.8e-64 1 TLR2_BUBBU Q2PZH4 Toll-like receptor 2 (CD282) (Prec 228.7 8e-64 1 TLR2_BOVIN Q95LA9 Toll-like receptor 2 (CD282) (Prec 227.3 2.1e-63 1 TLR2_BOSTR Q2V897 Toll-like receptor 2 (CD282) (Prec 226.9 2.7e-63 1 TLR2_SHEEP B2LT65 Toll-like receptor 2 (CD282) (Prec 225.2 8.7e-63 1 TLR2_GIRCA B2LT64 Toll-like receptor 2 (CD282) (Prec 224.4 1.6e-62 1 TLR2_BOSIN B5T267 Toll-like receptor 2 (CD282) (Prec 223.6 2.7e-62 1 TLR2_HORSE Q6T752 Toll-like receptor 2 (CD282) (Prec 222.4 6.3e-62 1 TLR2_BISBI B2LT61 Toll-like receptor 2 (CD282) (Prec 221.9 8.9e-62 1 TLR2_CANLF Q689D1 Toll-like receptor 2 (CD282) (Prec 221.0 1.6e-61 1 SIGIR_RAT Q4V892 Single Ig IL-1-related receptor (S 214.3 1.7e-59 1 TLR9_MOUSE Q9EQU3 Toll-like receptor 9 (CD289) (Prec 214.1 2e-59 1 TLR2_HUMAN O60603 Toll-like receptor 2 (Toll/interle 213.8 2.4e-59 1 TLR2_PANPA B3Y614 Toll-like receptor 2 (CD282) (Prec 213.8 2.4e-59 1 TLR2_PANTR B3Y613 Toll-like receptor 2 (CD282) (Prec 213.8 2.4e-59 1 TLR2_GORGO B3Y615 Toll-like receptor 2 (CD282) (Prec 213.8 2.4e-59 1 TLR2_MACFA Q95M53 Toll-like receptor 2 (CD282) (Prec 213.6 2.9e-59 1 TLR2_MACMU B3Y618 Toll-like receptor 2 (CD282) (Prec 213.6 2.9e-59 1 SIGIR_MOUSE Q9JLZ8 Single Ig IL-1-related receptor (S 213.4 3.2e-59 1 TLR8_MOUSE P58682 Toll-like receptor 8 (CD288) (Prec 206.1 4.9e-57 1 TLR2_MOUSE Q9QUN7 Toll-like receptor 2 (CD282) (Prec 202.6 5.7e-56 1 I18RA_MOUSE Q9Z2B1 Interleukin-18 receptor accessory 201.1 1.6e-55 1 TLR2_CRIGR Q9R1F8 Toll-like receptor 2 (CD282) (Prec 201.0 1.8e-55 1 SIGIR_HUMAN Q6IA17 Single Ig IL-1-related receptor (S 198.4 1.1e-54 1 TLR21_CHICK Q9DD78 Toll-like receptor 2 type-1 (Precu 194.9 1.2e-53 1 TLR22_CHICK Q9DGB6 Toll-like receptor 2 type-2 (Precu 194.9 1.2e-53 1 TLR12_MOUSE Q6QNU9 Toll-like receptor 12 {ECO:0000303 194.7 1.4e-53 1 TLR9_CANLF Q5I2M8 Toll-like receptor 9 (CD289) (Prec 192.3 7.1e-53 1 TLR9_FELCA Q5I2M7 Toll-like receptor 9 (CD289) (Prec 188.6 9.6e-52 1 TLR9_PIG Q5I2M3 Toll-like receptor 9 (CD289) (Prec 187.6 1.8e-51 1 TLR9_SHEEP Q5I2M4 Toll-like receptor 9 (CD289) (Prec 185.0 1.1e-50 1 TLR9_HORSE Q2EEY0 Toll-like receptor 9 {ECO:0000303| 183.6 3e-50 1 TLR9_HUMAN Q9NR96 Toll-like receptor 9 (CD289) (Prec 174.6 1.5e-47 1 TLR13_MOUSE Q6R5N8 Toll-like receptor 13 (Precursor) 173.2 4e-47 1 TLR9_BOVIN Q5I2M5 Toll-like receptor 9 (CD289) (Prec 172.4 7.3e-47 1 TLR1_HUMAN Q15399 Toll-like receptor 1 (Toll/interle 164.1 2.3e-44 1 TLR1_MOUSE Q9EPQ1 Toll-like receptor 1 (Toll/interle 157.9 1.7e-42 1 TLR6_MOUSE Q9EPW9 Toll-like receptor 6 (CD286) (Prec 154.3 2e-41 1 IRL1B_DANRE B6ZK77 Interleukin-1 receptor accessory p 150.1 3.7e-40 1 TLR6_DASNO Q0ZUL9 Toll-like receptor 6 (CD286) (Prec 146.5 4.3e-39 1 TLR7_MOUSE P58681 Toll-like receptor 7 (Precursor) 144.9 1.3e-38 1 IRPL2_MOUSE Q9ERS6 X-linked interleukin-1 receptor ac 144.6 1.7e-38 1 TLR7_HUMAN Q9NYK1 Toll-like receptor 7 (Precursor) 142.1 9.6e-38 1 TLR6_BOVIN Q704V6 Toll-like receptor 6 {ECO:0000312| 139.1 7.3e-37 1 IRPL2_HUMAN Q9NP60 X-linked interleukin-1 receptor ac 136.7 3.9e-36 1 TLR6_HUMAN Q9Y2C9 Toll-like receptor 6 (CD286) (Prec 136.2 5.4e-36 1 TLR10_HUMAN Q9BXR5 Toll-like receptor 10 (CD290) (Pre 133.3 4.2e-35 1 IRL1A_DANRE B6ZK76 Interleukin-1 receptor accessory p 129.1 7.9e-34 1 IRPL1_PONPY Q7YQL9 Interleukin-1 receptor accessory p 127.8 1.9e-33 1 IRPL1_PANTR P60029 Interleukin-1 receptor accessory p 127.8 1.9e-33 1 IRPL1_HUMAN Q9NZN1 Interleukin-1 receptor accessory p 127.8 1.9e-33 1 IRPL1_RAT P59824 Interleukin-1 receptor accessory p 127.8 1.9e-33 1 TOLL8_DROME Q9V477 Toll-like receptor Tollo {ECO:0000 119.6 5.7e-31 1 TOLL_DROME P08953 Protein toll (Precursor) 118.8 9.9e-31 1 IRPL1_MOUSE P59823 Interleukin-1 receptor accessory p 117.8 1.9e-30 1 TLR10_BOVIN Q6GV17 Toll-like receptor 10 (CD290) (Pre 102.1 1.1e-25 1 TOLL6_DROME Q9VUN0 Toll-like receptor 6 {ECO:0000305} 73.3 4.7e-17 1 TLR11_MOUSE Q6R5P0 Toll-like receptor 11 {ECO:0000303 59.6 6.4e-13 1 TLR3_MOUSE Q99MB1 Toll-like receptor 3 (CD283) (Prec 53.4 4.7e-11 1 Parsed for domains: Sequence Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- ILRL2_HUMAN 1/1 386 573 .. 1 190 [] 298.0 1.1e-84 ILRL1_MOUSE 1/1 385 567 .] 1 190 [] 296.3 3.5e-84 ILRL2_MOUSE 1/1 389 553 .. 1 190 [] 294.8 1e-83 ILRL1_HUMAN 1/1 380 549 .. 1 190 [] 289.5 3.9e-82 ILRL2_RAT 1/1 389 553 .. 1 190 [] 287.3 1.8e-81 ILRL1_RAT 1/1 384 566 .] 1 190 [] 282.6 4.7e-80 IL18R_MOUSE 1/1 375 537 .] 1 190 [] 268.8 6.7e-76 IL1R1_RAT 1/1 391 556 .. 1 190 [] 260.8 1.8e-73 TLR4_PIG 1/1 678 839 .. 1 190 [] 253.6 2.6e-71 TLR4_MOUSE 1/1 675 835 .] 1 190 [] 253.0 3.9e-71 TLR5_HUMAN 1/1 693 858 .] 1 190 [] 252.0 7.6e-71 IL1AP_RAT 1/1 405 567 .. 1 190 [] 251.9 8.1e-71 IL1AP_MOUSE 1/1 405 567 .. 1 190 [] 251.1 1.5e-70 IL1AP_MACMU 1/1 405 567 .. 1 190 [] 248.5 9e-70 IL1R1_MOUSE 1/1 388 556 .. 1 190 [] 247.8 1.4e-69 IL1AP_HUMAN 1/1 405 567 .. 1 190 [] 247.7 1.5e-69 TLR4_BOSTR 1/1 678 841 .] 1 190 [] 247.2 2.2e-69 TLR4_BOVIN 1/1 678 841 .] 1 190 [] 247.2 2.2e-69 I18RA_HUMAN 1/1 411 586 .. 1 190 [] 244.3 1.6e-68 TLR4_HORSE 1/1 679 840 .. 1 190 [] 243.9 2.1e-68 TLR4_RAT 1/1 675 835 .] 1 190 [] 243.9 2.1e-68 TLR4_CRIGR 1/1 675 836 .. 1 190 [] 243.3 3.2e-68 TLR5_MOUSE 1/1 694 856 .. 1 190 [] 241.8 8.9e-68 IL18R_HUMAN 1/1 378 536 .. 1 190 [] 232.8 4.6e-65 TLR4_GORGO 1/1 675 821 .. 1 190 [] 232.7 4.9e-65 TLR4_HUMAN 1/1 677 823 .. 1 190 [] 232.7 4.9e-65 TLR4_FELCA 1/1 678 828 .. 1 190 [] 232.4 6.1e-65 TLR4_PANPA 1/1 677 823 .. 1 190 [] 232.4 6.1e-65 IL1R1_HUMAN 1/1 385 553 .. 1 190 [] 232.4 6.2e-65 TLR4_PAPAN 1/1 677 823 .. 1 190 [] 232.0 8e-65 TLR2_CAPHI 1/1 641 784 .] 1 190 [] 230.3 2.6e-64 TLR2_CAPIB 1/1 641 784 .] 1 190 [] 230.3 2.6e-64 TLR8_HUMAN 1/1 880 1034 .. 1 190 [] 229.6 4.3e-64 TLR4_PONPY 1/1 675 821 .. 1 190 [] 229.4 4.8e-64 TLR2_BUBBU 1/1 641 784 .] 1 190 [] 228.7 8e-64 TLR2_BOVIN 1/1 641 784 .] 1 190 [] 227.3 2.1e-63 TLR2_BOSTR 1/1 641 784 .] 1 190 [] 226.9 2.7e-63 TLR2_SHEEP 1/1 641 784 .] 1 190 [] 225.2 8.7e-63 TLR2_GIRCA 1/1 641 784 .] 1 190 [] 224.4 1.6e-62 TLR2_BOSIN 1/1 641 784 .] 1 190 [] 223.6 2.7e-62 TLR2_HORSE 1/1 641 784 .] 1 190 [] 222.4 6.3e-62 TLR2_BISBI 1/1 641 784 .] 1 190 [] 221.9 8.9e-62 TLR2_CANLF 1/1 642 785 .] 1 190 [] 221.0 1.6e-61 SIGIR_RAT 1/1 164 314 .. 1 190 [] 214.3 1.7e-59 TLR9_MOUSE 1/1 873 1028 .. 1 190 [] 214.1 2e-59 TLR2_HUMAN 1/1 641 784 .] 1 190 [] 213.8 2.4e-59 TLR2_PANPA 1/1 641 784 .] 1 190 [] 213.8 2.4e-59 TLR2_PANTR 1/1 641 784 .] 1 190 [] 213.8 2.4e-59 TLR2_GORGO 1/1 641 784 .] 1 190 [] 213.8 2.4e-59 TLR2_MACFA 1/1 641 784 .] 1 190 [] 213.6 2.9e-59 TLR2_MACMU 1/1 641 784 .] 1 190 [] 213.6 2.9e-59 SIGIR_MOUSE 1/1 164 314 .. 1 190 [] 213.4 3.2e-59 TLR8_MOUSE 1/1 871 1025 .. 1 190 [] 206.1 4.9e-57 TLR2_MOUSE 1/1 641 784 .] 1 190 [] 202.6 5.7e-56 I18RA_MOUSE 1/1 410 570 .. 1 190 [] 201.1 1.6e-55 TLR2_CRIGR 1/1 641 784 .] 1 190 [] 201.0 1.8e-55 SIGIR_HUMAN 1/1 165 315 .. 1 190 [] 198.4 1.1e-54 TLR21_CHICK 1/1 650 793 .] 1 190 [] 194.9 1.2e-53 TLR22_CHICK 1/1 638 781 .] 1 190 [] 194.9 1.2e-53 TLR12_MOUSE 1/1 761 905 .. 1 190 [] 194.7 1.4e-53 TLR9_CANLF 1/1 873 1028 .. 1 190 [] 192.3 7.1e-53 TLR9_FELCA 1/1 871 1026 .. 1 190 [] 188.6 9.6e-52 TLR9_PIG 1/1 870 1025 .. 1 190 [] 187.6 1.8e-51 TLR9_SHEEP 1/1 869 1024 .. 1 190 [] 185.0 1.1e-50 TLR9_HORSE 1/1 871 1026 .. 1 190 [] 183.6 3e-50 TLR9_HUMAN 1/1 873 1028 .. 1 190 [] 174.6 1.5e-47 TLR13_MOUSE 1/1 834 990 .. 1 190 [] 173.2 4e-47 TLR9_BOVIN 1/1 870 1024 .. 1 190 [] 172.4 7.3e-47 TLR1_HUMAN 1/1 640 784 .. 1 190 [] 164.1 2.3e-44 TLR1_MOUSE 1/1 643 792 .. 1 190 [] 157.9 1.7e-42 TLR6_MOUSE 1/1 645 789 .. 1 190 [] 154.3 2e-41 IRL1B_DANRE 1/1 408 592 .. 1 190 [] 150.1 3.7e-40 TLR6_DASNO 1/1 644 788 .. 1 190 [] 146.5 4.3e-39 TLR7_MOUSE 1/1 892 1049 .. 1 190 [] 144.9 1.3e-38 IRPL2_MOUSE 1/1 402 577 .. 1 190 [] 144.6 1.7e-38 TLR7_HUMAN 1/1 891 1048 .. 1 190 [] 142.1 9.6e-38 TLR6_BOVIN 1/1 645 789 .. 1 190 [] 139.1 7.3e-37 IRPL2_HUMAN 1/1 402 577 .. 1 190 [] 136.7 3.9e-36 TLR6_HUMAN 1/1 645 789 .. 1 190 [] 136.2 5.4e-36 TLR10_HUMAN 1/1 637 799 .. 1 190 [] 133.3 4.2e-35 IRL1A_DANRE 1/1 412 595 .. 1 190 [] 129.1 7.9e-34 IRPL1_PONPY 1/1 405 591 .. 1 190 [] 127.8 1.9e-33 IRPL1_PANTR 1/1 405 591 .. 1 190 [] 127.8 1.9e-33 IRPL1_HUMAN 1/1 405 591 .. 1 190 [] 127.8 1.9e-33 IRPL1_RAT 1/1 405 591 .. 1 190 [] 127.8 1.9e-33 TOLL8_DROME 1/1 1076 1221 .. 1 190 [] 119.6 5.7e-31 TOLL_DROME 1/1 859 1029 .. 1 190 [] 118.8 9.9e-31 IRPL1_MOUSE 1/1 405 590 .. 1 190 [] 117.8 1.9e-30 TLR10_BOVIN 1/1 638 788 .. 1 190 [] 102.1 1.1e-25 TOLL6_DROME 1/1 1114 1269 .. 1 190 [] 73.3 4.7e-17 TLR11_MOUSE 1/1 774 926 .] 1 190 [] 59.6 6.4e-13 TLR3_MOUSE 1/1 757 905 .] 1 190 [] 53.4 4.7e-11 Alignments of top-scoring domains: ILRL2_HUMAN: domain 1 of 1, from 386 to 573: score 298.0, E = 1.1e-84 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD YV+Ypk p+++sq++ +d +v+++Lpe+ LErqcGYkL++++RD ILRL2_HUMA 386 YVLYPK--PHKESQRHAVDALVLNILPEV---LERQCGYKLFIFGRD 427 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL ++PG+ava+ +i+e++k +Rrliv+++p+ l +gll++l+E++iA+++aL ILRL2_HUMA 428 EFPGQAVAN-VIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSAL 476 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted i++++kvILIele+++dy+ +p+s+q++++++ ++++W+gDFte+ ILRL2_HUMA 477 IQDGMKVILIELEKIEDYT---VMPESIQYIKQKH---GAIRWHGDFTEQ 520 sqspksrFWkkLryamP...............skpkeankpkdeseaqsv sq++k++FWk++ry+mP+++ ++ ++ + ++++++++ +p+ s ILRL2_HUMA 521 SQCMKTKFWKTVRYHMPprrcrpfppvqllqhTPCYRTAGPELGS----- 565 sskkhllt<-* ++kk +lt ILRL2_HUMA 566 RRKKCTLT 573 ILRL1_MOUSE: domain 1 of 1, from 385 to 567: score 296.3, E = 3.5e-84 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y+iYp+vF++s+++ ++++++v+++Lp++ LE++cGYkLC+++RD ILRL1_MOUS 385 YIIYPRVFRGSAAGTHSVEYFVHHTLPDV---LENKCGYKLCIYGRD 428 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +lPG++ a+ ++++sI++SRr+++VL+ph+++s+ ++++E+eiAlh+aL ILRL1_MOUS 429 LLPGQDAAT-VVESSIQNSRRQVFVLAPHMMHSK--EFAYEQEIALHSAL 475 iennskvILIelepvsdysll..gslprslqrLrrvlqrqtylkWpgDFt i+nnskvILIe+ep+ + s+l+ g+l++slq+L++++ +++kW++D++ ILRL1_MOUS 476 IQNNSKVILIEMEPLGEASRLqvGDLQDSLQHLVKIQ---GTIKWREDHV 522 edsqspksrFWkkLryamP...skpkeankpkdes.eaqsvsskkhllt< +d+qs +s+FWk++ry+mP +++++k+a+++++ s++a+ +++kh+ ILRL1_MOUS 523 ADKQSLSSKFWKHVRYQMPvpeRASKTASVAAPLSgKAC--LDLKHF-- 567 -* ILRL1_MOUS - - ILRL2_MOUSE: domain 1 of 1, from 389 to 553: score 294.8, E = 1e-83 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD YV+Ypk +++ sq +d+d++v+++Lpe+ LE+qcGYkL++++RD ILRL2_MOUS 389 YVLYPK--YPRGSQGHDVDTLVLKILPEV---LEKQCGYKLFIFGRD 430 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL ++PG+ava+ +i+e+Ik +Rrl+v ++p+ ++g+l++l+E++iA+++aL ILRL2_MOUS 431 EFPGQAVAS-VIDENIKLCRRLMVFVAPESSSFGFLKNLSEEQIAVYNAL 479 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted i++++kvILIele+v+dys ++p+s+q++r+++ ++++W+gDFte+ ILRL2_MOUS 480 IQHGMKVILIELEKVKDYS---TMPESIQYIRQKH---GAIQWDGDFTEQ 523 sqspksrFWkkLryamP..skpkeankpkdeseaqsvsskkhllt<-* sq++k++FWkk+ry+mP++++p s+ +l+ ILRL2_MOUS 524 SQCAKTKFWKKVRYHMPprRYP---------------ASSPVQLL 553 ILRL1_HUMAN: domain 1 of 1, from 380 to 549: score 289.5, E = 3.9e-82 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD YV+Yp++++sst+++++++++v+++Lp++ LE++cGY LC+++RD ILRL1_HUMA 380 YVVYPRNYKSSTDGASRVEHFVHQILPDV---LENKCGYTLCIYGRD 423 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +lPGe+v++ ++ +I+kSRr+i++L+p++ +++ ++++E+e+Alh+aL ILRL1_HUMA 424 MLPGEDVVT-AVETNIRKSRRHIFILTPQITHNK--EFAYEQEVALHCAL 470 iennskvILIelepvsdysll..gslprslqrLrrvlqrqtylkWpgDFt i+n++kvILIe+e++s+ ++l+ ++l++slq+L++v+ +++kW++D++ ILRL1_HUMA 471 IQNDAKVILIEMEALSELDMLqaEALQDSLQHLMKVQ---GTIKWREDHI 517 edsqspksrFWkkLryamP..skpkeankpkdeseaqsvsskkhllt<-* ++++s +s+FWk++ry+mP +sk+ ++k+++lt ILRL1_HUMA 518 ANKRSLNSKFWKHVRYQMPvpSKI---------------PRKASSLT 549 ILRL2_RAT: domain 1 of 1, from 389 to 553: score 287.3, E = 1.8e-81 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD YV+Ypk ++++sq +d+d++v+++Lpe+ LE+qcGYkL++++RD ILRL2_RAT 389 YVLYPK--YPRESQGHDVDTLVLKILPEV---LEKQCGYKLFIFGRD 430 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL ++PG+ava+ +i+e+Ik +Rrl+v+++p+ ++++l++ltE++iA+++aL ILRL2_RAT 431 EFPGQAVAS-VIDENIKLCRRLMVLVAPETSSFSFLKNLTEEQIAVYNAL 479 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +++++kvILIele v+dys ++p+s+q++r+++ ++++W+gDFte+ ILRL2_RAT 480 VQDGMKVILIELERVKDYS---TMPESIQYIRQKH---GAIQWDGDFTEQ 523 sqspksrFWkkLryamP..skpkeankpkdeseaqsvsskkhllt<-* q++k++FWkk+ry+mP++++p s +l+ ILRL2_RAT 524 AQCAKTKFWKKVRYHMPprRYP---------------ASPPVQLL 553 ILRL1_RAT: domain 1 of 1, from 384 to 566: score 282.6, E = 4.7e-80 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y+iYp+vF++s+++ +++++v+ +Lp++ LE++cGYkLC+++RD ILRL1_RAT 384 YIIYPRVFRGSAAGTGSVEYFVHYTLPDV---LENKCGYKLCIYGRD 427 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +lPG++ a+ ++++sI++SRr+++VL+ph+++s+ ++++E+eiAlh+aL ILRL1_RAT 428 LLPGQDAAT-VVESSIQNSRRQVFVLAPHMMHSK--EFAYEQEIALHSAL 474 iennskvILIelepvsdysll..gslprslqrLrrvlqrqtylkWpgDFt i+nnskvILIe+ep + s+l+ g+l++slq+L++ + +++kW++D++ ILRL1_RAT 475 IQNNSKVILIEMEPMGEASRLqlGDLQDSLQHLVKMQ---GTIKWREDHV 521 edsqspksrFWkkLryamP...skpkeankpkdes.eaqsvsskkhllt< +d+qs +s+FWk++ry+mP ++++pk a+++++ s++ + +++kh+ ILRL1_RAT 522 ADKQSLSSKFWKHVRYQMPvpkRPPKMASVAAPLSgKVC--LDLKHF-- 566 -* ILRL1_RAT - - IL18R_MOUSE: domain 1 of 1, from 375 to 537: score 268.8, E = 6.7e-76 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +V+Y+k ++++++k+e+++++e+Lp++ LE+q+GYkLC++eRD IL18R_MOUS 375 FVSYLK---ECHPENKEEYTFAVETLPRV---LEKQFGYKLCIFERD 415 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL ++PG+av++ +i++ I+kSRrli+VLS+++l++g +++Ele +lh+aL IL18R_MOUS 416 VVPGGAVVE-EIHSLIEKSRRLIIVLSQSYLTNG---ARRELESGLHEAL 461 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +e+++k+ILIe++p s+++ +lp+sl++L++++ +lkW++D IL18R_MOUS 462 VERKIKIILIEFTPASNIT---FLPPSLKLLKSYR----VLKWRAD---- 500 sqspksrFWkkLryamPskpkeankpkdes.eaqsvsskkhllt<-* s+s++srFWk+L y m p++a+kp++e++e +++ + + IL18R_MOUS 501 SPSMNSRFWKNLVYLM---PAKAVKPWREEsE----ARSVLSAP 537 IL1R1_RAT: domain 1 of 1, from 391 to 556: score 260.8, E = 1.8e-73 *->YViYpkvFpsstsqskde...dwvvnelLpeldgfLErqcGYkLCle YV+Yp +t+++ ++ d++v++lLpe+ LE+q+GYkL+++ IL1R1_RAT 391 YVLYP-----KTYGEGSFaylDTFVFKLLPEV---LEGQFGYKLFIC 429 eRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcl...tElei +RD + Ge++++ +++e++k+SRrli++L++++ +++ cl++++E++i IL1R1_RAT 430 GRDDYVGEDTIE-VTNENVKRSRRLIIILVRDMGSFS---CLgqsSEEQI 475 AlhraLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWp A+++aLi++++k+IL ele+++dy+ ++p+s+q++++++ ++++W IL1R1_RAT 476 AIYDALIREGIKIILLELEKIQDYE---KMPESIQFIKQKH---GAICWS 519 gDFtedsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt< gDF+e++qs+k+rFWk+Lry+m p+++++p +sk+hllt IL1R1_RAT 520 GDFKERPQSAKTRFWKNLRYQM---PAQRRSP---------LSKHHLLT 556 -* IL1R1_RAT - - TLR4_PIG: domain 1 of 1, from 678 to 839: score 253.6, E = 2.6e-71 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_PIG 678 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFHLCLHYRD 712 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_PIG 713 FIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 760 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +++++++I+I+l+++++ sl+r++++L+r+l+r+tyl+W+ d TLR4_PIG 761 LRSHAGIIFIVLQKLEK-----SLLRQQVELYRLLSRNTYLEWE-----D 800 sqspksrFWkkLryamP.skpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++L++a+++ kp++ ++++d++ s+++ + + TLR4_PIG 801 SVLGRHIFWRRLKKALLdGKPWSPEGTEDSE-----SNQHDTTA 839 TLR4_MOUSE: domain 1 of 1, from 675 to 835: score 253.0, E = 3.9e-71 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s++edwv+nel+++l +E++++++LCl++RD TLR4_MOUSE 675 FVIYS---------SQNEDWVRNELVKNL---EEGVPRFHLCLHYRD 709 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_MOUSE 710 FIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSR--WCIFEYEIAQTWQF 757 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + ++s++I+I+le+v++ sl+r++++L+r+l+r+tyl+W+ d TLR4_MOUSE 758 LSSRSGIIFIVLEKVEK-----SLLRQQVELYRLLSRNTYLEWE-----D 797 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++ ++++FW++L++a+++ ++++ ++++e+ ++++ ++t TLR4_MOUSE 798 NPLGRHIFWRRLKNALLDGKASNPEQTAEE-----EQETATWT 835 TLR5_HUMAN: domain 1 of 1, from 693 to 858: score 252.0, E = 7.6e-71 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++Y+ ++s skd+ wv+n+lL++ld+++++q++++LC+eeRD TLR5_HUMAN 693 YDAYL-----CFS-SKDFTWVQNALLKHLDTQYSDQNRFNLCFEERD 733 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PGe+ ++ niq++I++SR++++++S+hfl++g wcl+++ +A+ r+L TLR5_HUMAN 734 FVPGENRIA-NIQDAIWNSRKIVCLVSRHFLRDG--WCLEAFSYAQGRCL 780 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +++ns++I+++++++s+y+ ++++q +r++ q+q+yl+Wp+D TLR5_HUMAN 781 SDLNSALIMVVVGSLSQYQ-----LMKHQSIRGFVQKQQYLRWPED---- 821 sqspksrFWkkLryamPskpkeankpkdes.eaqsvsskkhllt<-* +++++F++kL++++ ++ke++k+kd++ + ++++ ++ TLR5_HUMAN 822 -FQDVGWFLHKLSQQI--LKKEKEKKKDNNiP----LQTVATIS 858 IL1AP_RAT: domain 1 of 1, from 405 to 567: score 251.9, E = 8.1e-71 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y+iY+ s++++++e+++v+++L+ + LE+++GYkLC+++RD IL1AP_RAT 405 YDIYV-----SYARNAEEEEFVLLTLRGV---LENEFGYKLCIFDRD 443 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +PG++v+d +++++I+kSRrl+vVLSp+++ +g +++l+El+++l+++ IL1AP_RAT 444 SFPGGIVTD-ETLSFIQKSRRLLVVLSPNYVLQG-TQALLELKAGLENMA 491 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted ++ n++vIL+++++v+d + +++l+r+++vl t++kW+g+ + IL1AP_RAT 492 SRGNINVILVQYKAVKDLK-----VKELKRAKSVL---TVIKWKGE---K 530 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s++p++rFWk+L++amP+k++++++++d+ + ++++++ IL1AP_RAT 531 SKYPQGRFWKQLQVAMPVKKSPRWSSSDK------QGLSYSSL 567 IL1AP_MOUSE: domain 1 of 1, from 405 to 567: score 251.1, E = 1.5e-70 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y+iY+ s++++ +e+++v+++L+ + LE+++GYkLC+++RD IL1AP_MOUS 405 YDIYV-----SYARNVEEEEFVLLTLRGV---LENEFGYKLCIFDRD 443 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL lPG++v+d +++++I+kSRrl+vVLSp+++ +g +++l+El+++l+++ IL1AP_MOUS 444 SLPGGIVTD-ETLSFIQKSRRLLVVLSPNYVLQG-TQALLELKAGLENMA 491 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted ++ n++vIL+++++v+d++ +++l+r++ vl t++kW+g+ + IL1AP_MOUS 492 SRGNINVILVQYKAVKDMK-----VKELKRAKTVL---TVIKWKGE---K 530 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s++p++rFWk+L++amP+k++++++++d+ + ++++++ IL1AP_MOUS 531 SKYPQGRFWKQLQVAMPVKKSPRWSSNDK------QGLSYSSL 567 IL1AP_MACMU: domain 1 of 1, from 405 to 567: score 248.5, E = 9e-70 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y+iY+ s++++++e+++v+++L+ + LE+++GYkLC+++RD IL1AP_MACM 405 YDIYV-----SYARNAEEEEFVLLTLRGV---LENEFGYKLCIFDRD 443 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL lPG++v+d +++++I+kSRrl+vVLSp+++ +g +++l+El+++l+++ IL1AP_MACM 444 SLPGGIVTD-ETLSFIQKSRRLLVVLSPNYVLQG-TQALLELKAGLENMA 491 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted ++ n++vIL+++++v++ + +++l+r++ vl t++kW+g+ + IL1AP_MACM 492 SQGNINVILVQYKAVKETK-----VKELKRAKTVL---TVIKWKGE---K 530 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s++p++rFWk+L++amP+k++++++++de + ++++++ IL1AP_MACM 531 SKYPQGRFWKQLQVAMPVKKSPRRSSSDE------QGLSYSSL 567 IL1R1_MOUSE: domain 1 of 1, from 388 to 556: score 247.8, E = 1.4e-69 *->YViYpkvFpsstsqskde...dwvvnelLpeldgfLErqcGYkLCle Y++Y+ +++t ++ ++++ d++v++lLpe+ LE+q+GYkL+++ IL1R1_MOUS 388 YDAYI--LYPKTLGEGSFsdlDTFVFKLLPEV---LEGQFGYKLFIY 429 eRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcl..tEleiA +RD + Ge++++ +++e++kkSRrli++L++++ ++ w +++E++iA IL1R1_MOUS 430 GRDDYVGEDTIE-VTNENVKKSRRLIIILVRDMGGFS--WLGqsSEEQIA 476 lhraLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpg +++aLi++++k++L ele+++dy+ ++p+s+q++++++ ++++W g IL1R1_MOUS 477 IYNALIQEGIKIVLLELEKIQDYE---KMPDSIQFIKQKH---GVICWSG 520 DFtedsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<- DF e++qs+k+rFWk+Lry+m p+++++p +sk++llt IL1R1_MOUS 521 DFQERPQSAKTRFWKNLRYQM---PAQRRSP---------LSKHRLLT 556 * IL1R1_MOUS - - IL1AP_HUMAN: domain 1 of 1, from 405 to 567: score 247.7, E = 1.5e-69 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y+iY+ s++++++e+++v+++L+ + LE+++GYkLC+++RD IL1AP_HUMA 405 YDIYV-----SYARNAEEEEFVLLTLRGV---LENEFGYKLCIFDRD 443 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL lPG++v+d +++++I+kSRrl+vVLSp+++ +g +++l+El+++l+++ IL1AP_HUMA 444 SLPGGIVTD-ETLSFIQKSRRLLVVLSPNYVLQG-TQALLELKAGLENMA 491 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted ++ n++vIL+++++v++ + +++l+r++ vl t++kW+g+ + IL1AP_HUMA 492 SRGNINVILVQYKAVKETK-----VKELKRAKTVL---TVIKWKGE---K 530 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s++p++rFWk+L++amP+k++++++++de + ++++++ IL1AP_HUMA 531 SKYPQGRFWKQLQVAMPVKKSPRRSSSDE------QGLSYSSL 567 TLR4_BOSTR: domain 1 of 1, from 678 to 841: score 247.2, E = 2.2e-69 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_BOSTR 678 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 712 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_BOSTR 713 FIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 760 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l+++++ sl+r++++L+r+l+r+tyl+W+ d TLR4_BOSTR 761 LSSRAGIIFIVLQKLEK-----SLLRQQVELYRLLSRNTYLEWE-----D 800 sqspksrFWkkLryamP.skpkeankpkdes.eaqsvsskkhllt<-* s+ +++ FW++Lr+a++ kp + ++++d ++ ++++ ++t TLR4_BOSTR 801 SVLGRHVFWRRLRKALLaGKPQSPEGTADAEtN----PQEATTST 841 TLR4_BOVIN: domain 1 of 1, from 678 to 841: score 247.2, E = 2.2e-69 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_BOVIN 678 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 712 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_BOVIN 713 FIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 760 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l+++++ sl+r++++L+r+l+r+tyl+W+ d TLR4_BOVIN 761 LSSRAGIIFIVLQKLEK-----SLLRQQVELYRLLSRNTYLEWE-----D 800 sqspksrFWkkLryamP.skpkeankpkdes.eaqsvsskkhllt<-* s+ +++ FW++Lr+a++ kp + ++++d ++ ++++ ++t TLR4_BOVIN 801 SVLGRHVFWRRLRKALLaGKPQSPEGTADAEtN----PQEATTST 841 I18RA_HUMAN: domain 1 of 1, from 411 to 586: score 244.3, E = 1.6e-68 *->YViYpkv..FpsstsqskdedwvvnelLpeldgfLErqcGYkLClee +V+Y k+++Fps++++s +e++++++l+p++ LE+++GY LCl e I18RA_HUMA 411 FVSYAKWssFPSEATSSLSEEHLALSLFPDV---LENKYGYSLCLLE 454 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+ PG+ +a+ +i+++Ik+SRr i++LSp++++ + ++El++A+++ I18RA_HUMA 455 RDVAPGGVYAE-DIVSIIKRSRRGIFILSPNYVNGP---SIFELQAAVNL 500 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt aL++++ k+ILI+++++++++ slp++++++ rvl ++++W+g I18RA_HUMA 501 ALDDQTLKLILIKFCYFQEPE---SLPHLVKKALRVL---PTVTWRGL-- 542 edsqspksrFWkkLryamP...............skpkeankpkdeseaq +s++p+srFW+k+ry+mP +++++ + ++ + +s++ I18RA_HUMA 543 -KSVPPNSRFWAKMRYHMPvknsqgftwnqlritSRI------------- 578 svsskkhllt<-* +++k+l++ I18RA_HUMA 579 --FQWKGLSR 586 TLR4_HORSE: domain 1 of 1, from 679 to 840: score 243.9, E = 2.1e-68 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_HORSE 679 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 713 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_HORSE 714 FIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 761 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l ++++ sl+r++++L+r+l+r+tyl+W+ d TLR4_HORSE 762 LSSRAGIIFIVLHKLEK-----SLLRQQVELYRLLNRNTYLEWE-----D 801 sqspksrFWkkLryamP.skpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++Lr+a+++ kp++ +++d +s+ h TLR4_HORSE 802 SVLGRHIFWRRLRKALLdGKPWSPAGTADAA-----ESRQHDAE 840 TLR4_RAT: domain 1 of 1, from 675 to 835: score 243.9, E = 2.1e-68 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s++edwv+nel+++l +E++++++LCl++RD TLR4_RAT 675 FVIYS---------SQNEDWVRNELVKNL---EEGVPRFQLCLHYRD 709 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_RAT 710 FIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSR--WCIFEYEIAQTWQF 757 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + ++s++I+I+le+v++ sl+r++++L+r+l+r+tyl+W+ d TLR4_RAT 758 LSSRSGIIFIVLEKVEK-----SLLRQQVELYRLLSRNTYLEWE-----D 797 sqspksrFWkkLryamPskpkeankpkdes.eaqsvsskkhllt<-* + ++++FW++L++a+ + +a +p+++s+e ++++ +lt TLR4_RAT 798 NALGRHIFWRRLKKAL--LDGKALNPDETSeE----EQEATTLT 835 TLR4_CRIGR: domain 1 of 1, from 675 to 836: score 243.3, E = 3.2e-68 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_CRIGR 675 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 709 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_CRIGR 710 FIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSR--WCIFEYEIAQTWQF 757 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + ++s++I+I+le+v++ sl++++++L+r+l+r+tyl+W+ d TLR4_CRIGR 758 LSSHSGIIFIVLEKVEK-----SLLKQQVELYRLLSRNTYLEWE-----D 797 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW++L++a+ + +a++p+ ea+ ++ + t TLR4_CRIGR 798 NALGRHIFWRRLKKAL--LDGRAWNPEGATEAE--NNQQETTT 836 TLR5_MOUSE: domain 1 of 1, from 694 to 856: score 241.8, E = 8.9e-68 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++Y+ ++s skd++w +n+lL++ld++++ +++++LC+eeRD TLR5_MOUSE 694 YDAYF-----CFS-SKDFEWAQNALLKHLDAHYSSRNRLRLCFEERD 734 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PGe++++ niq+++++SR++++++S+hflk+g wcl+++++A++r L TLR5_MOUSE 735 FIPGENHIS-NIQAAVWGSRKTVCLVSRHFLKDG--WCLEAFRYAQSRSL 781 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted ++++s +I ++++++s+y+ +++++ +r++lq+q+yl+Wp+D TLR5_MOUSE 782 SDLKSILIVVVVGSLSQYQ-----LMRHETIRGFLQKQQYLRWPED---- 822 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +++++F++kL+ ++ ke++++k++s s + ++++ TLR5_MOUSE 823 -LQDVGWFLDKLSGCI---LKEEKGKKRSS-----SIQLRTIA 856 IL18R_HUMAN: domain 1 of 1, from 378 to 536: score 232.8, E = 4.6e-65 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +V+Y+k ++ +++ +e ++++e+Lp++ LE+ +GYkLC++eRD IL18R_HUMA 378 FVSYLK---ECRPENGEEHTFAVEILPRV---LEKHFGYKLCIFERD 418 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL ++PG+av+d +i++ I+kSRrli+VLS+++++++ ++Ele +lh+aL IL18R_HUMA 419 VVPGGAVVD-EIHSLIEKSRRLIIVLSKSYMSNE---VRYELESGLHEAL 464 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +e+++k+ILIe++pv d + +lp+sl++L++++ +lkW++D + IL18R_HUMA 465 VERKIKIILIEFTPVTDFT---FLPQSLKLLKSHR----VLKWKAD---K 504 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s s +srFWk+L y m p++++kp +++ l+ IL18R_HUMA 505 SLSYNSRFWKNLLYLM---PAKTVKPG--------RDEPEVLP 536 TLR4_GORGO: domain 1 of 1, from 675 to 821: score 232.7, E = 4.9e-65 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_GORGO 675 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 709 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+i+e+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_GORGO 710 FIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 757 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l++v++ +l+r++++L+r+l+r+tyl+W+ d TLR4_GORGO 758 LSSRAGIIFIVLQKVEK-----TLLRQQVELYRLLSRNTYLEWE-----D 797 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++Lr+a+ ++ k+ ++ TLR4_GORGO 798 SVLGRHIFWRRLRKAL-------------------LDGKSWNP 821 TLR4_HUMAN: domain 1 of 1, from 677 to 823: score 232.7, E = 4.9e-65 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_HUMAN 677 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 711 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+i+e+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_HUMAN 712 FIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 759 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l++v++ +l+r++++L+r+l+r+tyl+W+ d TLR4_HUMAN 760 LSSRAGIIFIVLQKVEK-----TLLRQQVELYRLLSRNTYLEWE-----D 799 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++Lr+a+ ++ k+ ++ TLR4_HUMAN 800 SVLGRHIFWRRLRKAL-------------------LDGKSWNP 823 TLR4_FELCA: domain 1 of 1, from 678 to 828: score 232.4, E = 6.1e-65 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_FELCA 678 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 712 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+iqe+++kSR++ivV+S+hf++s+ wc++E+ iA+++++ TLR4_FELCA 713 FIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSR--WCIFEYGIAQTWQF 760 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l+++++ sl+r++++L+r+l+r+tyl+W+ d TLR4_FELCA 761 LSSRAGIIFIVLQKLEK-----SLLRQQVELYRLLNRNTYLEWE-----D 800 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++Lr+a+++ + ++ ++ TLR4_FELCA 801 SVLGRHIFWRRLRKALLDGK---------------PRCPEGMA 828 TLR4_PANPA: domain 1 of 1, from 677 to 823: score 232.4, E = 6.1e-65 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_PANPA 677 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 711 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+i+e+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_PANPA 712 FIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 759 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l++v++ +l+r++++L+r+l+r+tyl+W+ d TLR4_PANPA 760 LSSRAGIIFIVLQKVEK-----TLLRRQVELYRLLSRNTYLEWE-----D 799 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++Lr+a+ ++ k+ ++ TLR4_PANPA 800 SVLGRHIFWRRLRKAL-------------------LDGKSWNP 823 IL1R1_HUMAN: domain 1 of 1, from 385 to 553: score 232.4, E = 6.2e-65 *->YViYpkvFpsstsqskde...dwvvnelLpeldgfLErqcGYkLCle Y++Y+ +++t ++ ++++ d +v++ Lpe+ LE+qcGYkL+++ IL1R1_HUMA 385 YDAYI--LYPKTVGEGSTsdcDIFVFKVLPEV---LEKQCGYKLFIY 426 eRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcl..tEleiA +RD + Ge++++ +i+e++kkSRrli++L+++ ++ w +++E++iA IL1R1_HUMA 427 GRDDYVGEDIVE-VINENVKKSRRLIIILVRETSGFS--WLGgsSEEQIA 473 lhraLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpg ++aL+++++kv+L ele+++dy+ ++p+s++++++++ ++++W g IL1R1_HUMA 474 MYNALVQDGIKVVLLELEKIQDYE---KMPESIKFIKQKH---GAIRWSG 517 DFtedsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<- DFt +qs+k+rFWk++ry+m p ++++p ssk++ll IL1R1_HUMA 518 DFTQGPQSAKTRFWKNVRYHM---PVQRRSP---------SSKHQLLS 553 * IL1R1_HUMA - - TLR4_PAPAN: domain 1 of 1, from 677 to 823: score 232.0, E = 8e-65 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E++++++LCl++RD TLR4_PAPAN 677 FVIYS---------SQDEDWVRNELVKNL---EEGVPPFQLCLHYRD 711 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+i+e+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_PAPAN 712 FIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 759 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l++v++ +l+r++++L+r+l+r+tyl+W+ d TLR4_PAPAN 760 LSSRAGIIFIVLQKVEK-----TLLRQQVELYRLLSRNTYLEWE-----D 799 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++Lr+a+ ++ ++ ++ TLR4_PAPAN 800 SVLGQHIFWRRLRKAL-------------------LDGRSWNP 823 TLR2_CAPHI: domain 1 of 1, from 641 to 784: score 230.3, E = 2.6e-64 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_CAPHI 641 YDAFV-----SYS-EQDSYWVENLMVQEL---EHFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kSR++i+VLS++f++s+ wc++El+++++r++ TLR2_CAPHI 679 FVPGKWIID-NIIDSIEKSRKTIFVLSENFVRSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_CAPHI 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPTD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +++++ FW +Lr+a+ + TLR2_CAPHI 768 -ETQQEAFWLNLRAAI-------------------------RS 784 TLR2_CAPIB: domain 1 of 1, from 641 to 784: score 230.3, E = 2.6e-64 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_CAPIB 641 YDAFV-----SYS-EQDSYWVENLMVQEL---EHFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kSR++i+VLS++f++s+ wc++El+++++r++ TLR2_CAPIB 679 FVPGKWIID-NIIDSIEKSRKTIFVLSENFVRSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_CAPIB 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPTD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +++++ FW +Lr+a+ + TLR2_CAPIB 768 -ETQQEAFWLNLRAAI-------------------------RS 784 TLR8_HUMAN: domain 1 of 1, from 880 to 1034: score 229.6, E = 4.3e-64 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLE.rqcGYkLCleeR Y++Y++ ++t++++++dwv+nel+++l +E+r+++ LCleeR TLR8_HUMAN 880 YDAYIS---YDTKDASVTDWVINELRYHL---EEsRDKNVLLCLEER 920 DflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhra D+ PG a++d n+++sI++S+++++VL++++ ks+ +++t++++Al+r+ TLR8_HUMAN 921 DWDPGLAIID-NLMQSINQSKKTVFVLTKKYAKSW--NFKTAFYLALQRL 967 LiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte ++en++++I+I+lepv ++s +++r++qr+++ + +l+Wp TLR8_HUMAN 968 MDENMDVIIFILLEPVLQHS---QYLRLRQRICKSS----ILQWP----- 1005 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* d++++++ FW++Lr+++ ++n +s++++++ TLR8_HUMAN 1006 DNPKAEGLFWQTLRNVV----LTEN-----------DSRYNNMY 1034 TLR4_PONPY: domain 1 of 1, from 675 to 821: score 229.4, E = 4.8e-64 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +ViY+ s+dedwv+nel+++l +E+++ ++LCl++RD TLR4_PONPY 675 FVIYS---------SQDEDWVRNELVKNL---EEGVPTFQLCLHYRD 709 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+a+a+N+i+e+++kSR++ivV+S+hf++s+ wc++E+eiA+++++ TLR4_PONPY 710 FIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSR--WCIFEYEIAQTWQF 757 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted + +++++I+I+l++v++ +l+r++++L+r+l+r+tyl+W+ d TLR4_PONPY 758 LSSRAGIIFIVLQKVEK-----TLLRQQVELYRLLSRNTYLEWE-----D 797 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s+ ++++FW++Lr+a+ ++ k+ ++ TLR4_PONPY 798 SVLGRHIFWRRLRKAL-------------------LDGKSWNP 821 TLR2_BUBBU: domain 1 of 1, from 641 to 784: score 228.7, E = 8e-64 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_BUBBU 641 YDAFV-----SYS-EQDSYWVENLMVQEL---EHFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++i+VLS++f+ks+ wc++El+++++r++ TLR2_BUBBU 679 FIPGKWIID-NIIDSIEKSHKTIFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_BUBBU 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPVD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++FW +Lr+a+ + TLR2_BUBBU 768 -ETQQEGFWLNLRAAI-------------------------RS 784 TLR2_BOVIN: domain 1 of 1, from 641 to 784: score 227.3, E = 2.1e-63 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_BOVIN 641 YDAFV-----SYS-ERDSYWVENLMVQEL---EHFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++i+VLS++f+ks+ wc++El+++++r++ TLR2_BOVIN 679 FIPGKWIID-NIIDSIEKSHKTIFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_BOVIN 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPVD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++FW +Lr+a+ + TLR2_BOVIN 768 -ETQQEGFWLNLRAAI-------------------------RS 784 TLR2_BOSTR: domain 1 of 1, from 641 to 784: score 226.9, E = 2.7e-63 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_BOSTR 641 YDAFV-----SYS-ERDSYWVENLMVQEL---EHFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++i+VLS++f+ks+ wc++El+++++r++ TLR2_BOSTR 679 FIPGKWIID-NIIDSIEKSHKTIFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++vILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_BOSTR 726 DENNDAVILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPLD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++FW +Lr+a+ + TLR2_BOSTR 768 -ETQQEGFWLNLRAAI-------------------------RS 784 TLR2_SHEEP: domain 1 of 1, from 641 to 784: score 225.2, E = 8.7e-63 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_SHEEP 641 YDAFV-----SYS-ERDSYWVENLMVQEL---EHFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kSR++i+VLS++f++s+ wc++El+++++r++ TLR2_SHEEP 679 FVPGKWIID-NIIDSIEKSRKTIFVLSESFVRSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ p+++++Lr++++++tyl+Wp D TLR2_SHEEP 726 DENNDAAILILLEPIDKKA----VPQRFCKLRKIMNTRTYLEWPTD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +++++ FW +Lr+a+ + TLR2_SHEEP 768 -ETHREAFWLNLRAAI-------------------------RS 784 TLR2_GIRCA: domain 1 of 1, from 641 to 784: score 224.4, E = 1.6e-62 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_GIRCA 641 YDAFV-----SYS-ERDSYWVENLMVREL---EHFDPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++i+VLS++f+ks+ wc++El+++++r++ TLR2_GIRCA 679 FIPGKWIID-NIIDSIEKSHKTIFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr+v++++tyl+Wp D TLR2_GIRCA 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKVMNTKTYLEWPMD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++FW +Lr+a+ + TLR2_GIRCA 768 -ETQQEGFWLNLRAAV-------------------------RS 784 TLR2_BOSIN: domain 1 of 1, from 641 to 784: score 223.6, E = 2.7e-62 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el + +++++kLCl++RD TLR2_BOSIN 641 YDAFV-----SYS-ERDSYWVENLMVQEL---EQFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++i+VLS++f+ks+ wc++El+++++r++ TLR2_BOSIN 679 FIPGKWIID-NIIDSIEKSHKTIFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_BOSIN 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPVD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++FW +Lr+a+ + TLR2_BOSIN 768 -ETQQEGFWLNLRAAI-------------------------RS 784 TLR2_HORSE: domain 1 of 1, from 641 to 784: score 222.4, E = 6.3e-62 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el +++++++kLCl++RD TLR2_HORSE 641 YDAFV-----SYS-ERDSYWVENLMVQEL---EHFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++i+VLS++f+ks+ wc++El+++++r++ TLR2_HORSE 679 FIPGKWIID-NIIDSIEKSHKTIFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_HORSE 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPTD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW +Lr+a+ TLR2_HORSE 768 -EAQQEGFWLNLRAAI-------------------------KS 784 TLR2_BISBI: domain 1 of 1, from 641 to 784: score 221.9, E = 8.9e-62 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++el + +++++kLCl++RD TLR2_BISBI 641 YDAFV-----SYS-ERDSYWVENLMVQEL---EQFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++i+VLS++f+ s+ wc++El+++++r++ TLR2_BISBI 679 FIPGKWIID-NIIDSIEKSHKTIFVLSENFVXSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_BISBI 726 DENNDAAILILLEPIDKKA----IPQRFCKLRKIMNTKTYLEWPVD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++FW +Lr+a+ + TLR2_BISBI 768 -ETQQEGFWLNLRAAI-------------------------RS 784 TLR2_CANLF: domain 1 of 1, from 642 to 785: score 221.0, E = 1.6e-61 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n+l++ l +++++++kLCl++RD TLR2_CANLF 642 YDAFV-----SYS-EHDSYWVENLLVQKL---EHFNPPFKLCLHKRD 679 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kSR++i+VLS++f+ks+ wc++El+++++r++ TLR2_CANLF 680 FIPGKWIID-NIIDSIEKSRKTIFVLSENFVKSE--WCKYELDFSHFRLF 726 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +en ++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_CANLF 727 DENSDAAILILLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPTD---- 768 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++FW +Lr+a+ TLR2_CANLF 769 -DAQQEGFWLNLRTAI-------------------------KS 785 SIGIR_RAT: domain 1 of 1, from 164 to 314: score 214.3, E = 1.7e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++Y+ s+s++++++++vn++L+++ LEr++GYkL+le+RD SIGIR_RAT 164 YDAYV-----SYSDRPEDRKFVNFILKPQ---LERRRGYKLFLEDRD 202 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +lP++++ + +++ +++++RrlivVLS++fl+++ wc ++++ +l+r+L SIGIR_RAT 203 LLPRAEPSA-DLLVNLSRCRRLIVVLSDAFLRRP--WCSQSFREGLCRLL 249 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e+++++I+I++e +++++ ++++l++Lr++++++t l+W+++ SIGIR_RAT 250 -ELTRRPIFITFEGQRREP----IHPALRLLRQHRHLVTLLLWKPG---- 290 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s++p+s+FWk+L+ a+ ++k+++++ SIGIR_RAT 291 SVTPSSDFWKELQLAL-------------------PRKVQYRP 314 TLR9_MOUSE: domain 1 of 1, from 873 to 1028: score 214.1, E = 2e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErq..cGYkLClee +V++ ++qs++ dwv+nel+ +l +Er++++ ++LCle+ TLR9_MOUSE 873 FVVFD------KAQSAVADWVYNELRVRL---EERRgrRALRLCLED 910 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+lPG++ ++ n+++sI++SR++++VL+++ + sg +t++ +A++r TLR9_MOUSE 911 RDWLPGQTLFE-NLWASIYGSRKTLFVLAHTDRVSG--LLRTSFLLAQQR 957 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l+p ++s +++r++qrL+r++ +l+Wp TLR9_MOUSE 958 LLEDRKDVVVLVILRPDAHRS---RYVRLRQRLCRQS----VLFWP---- 996 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++++FW++L++a+ +++n+++ ++++++++ TLR9_MOUSE 997 -QQPNGQGGFWAQLSTAL----TRDNRHF--------YNQNFCRG 1028 TLR2_HUMAN: domain 1 of 1, from 641 to 784: score 213.8, E = 2.4e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d +wv+n++++el + +++++kLCl++RD TLR2_HUMAN 641 YDAFV-----SYS-ERDAYWVENLMVQEL---ENFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f+ks+ wc++El+++++r++ TLR2_HUMAN 679 FIPGKWIID-NIIDSIEKSHKTVFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_HUMAN 726 DENNDAAILILLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPMD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW +Lr+a+ TLR2_HUMAN 768 -EAQREGFWVNLRAAI-------------------------KS 784 TLR2_PANPA: domain 1 of 1, from 641 to 784: score 213.8, E = 2.4e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d +wv+n++++el + +++++kLCl++RD TLR2_PANPA 641 YDAFV-----SYS-ERDAYWVENLMVQEL---ENFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f+ks+ wc++El+++++r++ TLR2_PANPA 679 FIPGKWIID-NIIDSIEKSHKTVFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_PANPA 726 DENNDAAILILLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPMD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW +Lr+a+ TLR2_PANPA 768 -EAQREGFWVNLRAAI-------------------------KS 784 TLR2_PANTR: domain 1 of 1, from 641 to 784: score 213.8, E = 2.4e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d +wv+n++++el + +++++kLCl++RD TLR2_PANTR 641 YDAFV-----SYS-ERDAYWVENLMVQEL---ENFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f+ks+ wc++El+++++r++ TLR2_PANTR 679 FIPGKWIID-NIIDSIEKSHKTVFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_PANTR 726 DENNDAAILILLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPMD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW +Lr+a+ TLR2_PANTR 768 -EAQREGFWVNLRAAI-------------------------KS 784 TLR2_GORGO: domain 1 of 1, from 641 to 784: score 213.8, E = 2.4e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d +wv+n++++el + +++++kLCl++RD TLR2_GORGO 641 YDAFV-----SYS-ERDAYWVENLMVQEL---ENFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f+ks+ wc++El+++++r++ TLR2_GORGO 679 FIPGKWIID-NIIDSIEKSHKTVFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_GORGO 726 DENNDAAILILLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPMD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW +Lr+a+ TLR2_GORGO 768 -EAQREGFWVNLRAAI-------------------------KS 784 TLR2_MACFA: domain 1 of 1, from 641 to 784: score 213.6, E = 2.9e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d +wv+n++++el + +++++kLCl++RD TLR2_MACFA 641 YDAFV-----SYS-ERDAYWVENLMVQEL---ENFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f+ks+ wc++El+++++r++ TLR2_MACFA 679 FIPGKWIID-NIIDSIEKSHKTVFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ IL++lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_MACFA 726 DENNDAAILVLLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPMD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW +Lr+a+ TLR2_MACFA 768 -EARQEGFWVNLRAAI-------------------------KS 784 TLR2_MACMU: domain 1 of 1, from 641 to 784: score 213.6, E = 2.9e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d +wv+n++++el + +++++kLCl++RD TLR2_MACMU 641 YDAFV-----SYS-ERDAYWVENLMVQEL---ENFNPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f+ks+ wc++El+++++r++ TLR2_MACMU 679 FIPGKWIID-NIIDSIEKSHKTVFVLSENFVKSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ IL++lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_MACMU 726 DENNDAAILVLLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPMD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++++FW +Lr+a+ TLR2_MACMU 768 -EARQEGFWVNLRAAI-------------------------KS 784 SIGIR_MOUSE: domain 1 of 1, from 164 to 314: score 213.4, E = 3.2e-59 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++Y+ s+s++++++++vn++L+++ LEr++GYkL+le+RD SIGIR_MOUS 164 YDAYV-----SYSDCPEDRKFVNFILKPQ---LERRRGYKLFLEDRD 202 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +lP++++ + +++ +++++RrlivVLS++fl+++ wc ++++ +l+r+L SIGIR_MOUS 203 LLPRAEPSA-DLLVNLSRCRRLIVVLSDAFLSRP--WCSQSFREGLCRLL 249 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e+++++I+I++e +++++ ++++l++Lr++++++t ++W+++ SIGIR_MOUS 250 -ELTRRPIFITFEGQRREP----IHPALRLLRQHRHLVTLVLWKPG---- 290 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s++p+s+FWk+L+ a+ ++k+++++ SIGIR_MOUS 291 SVTPSSDFWKELQLAL-------------------PRKVQYRP 314 TLR8_MOUSE: domain 1 of 1, from 871 to 1025: score 206.1, E = 4.9e-57 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLE.rqcGYkLCleeR Y++Y++ ++t++++++dwv+nel+++l +E+ ++ LCleeR TLR8_MOUSE 871 YDAYIS---YDTKDASVTDWVINELRYHL---EEsEDKSVLLCLEER 911 DflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhra D+ PG ++d n+++sI++S+++i+VL++++ ks+ +++t++++Al+r+ TLR8_MOUSE 912 DWDPGLPIID-NLMQSINQSKKTIFVLTKKYAKSW--NFKTAFYLALQRL 958 LiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte ++en++++I+I+lepv +ys +++r++qr+++ + +l+Wp TLR8_MOUSE 959 MDENMDVIIFILLEPVLQYS---QYLRLRQRICKSS----ILQWP----- 996 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++++ FW+ L++++ ++n +s++ l+ TLR8_MOUSE 997 NNPKAENLFWQSLKNVV----LTEN-----------DSRYDDLY 1025 TLR2_MOUSE: domain 1 of 1, from 641 to 784: score 202.6, E = 5.7e-56 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d+ wv+n++++ l + ++++kLCl++RD TLR2_MOUSE 641 YDAFV-----SYS-EQDSHWVENLMVQQL---ENSDPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f++s+ wc++El+++++r++ TLR2_MOUSE 679 FVPGKWIID-NIIDSIEKSHKTVFVLSENFVRSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ IL++lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_MOUSE 726 DENNDAAILVLLEPIERKA----IPQRFCKLRKIMNTKTYLEWPLD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + +++ FW +Lr+a+ TLR2_MOUSE 768 -EGQQEVFWVNLRTAI-------------------------KS 784 I18RA_MOUSE: domain 1 of 1, from 410 to 570: score 201.1, E = 1.6e-55 *->YViYpkv..FpsstsqskdedwvvnelLpeldgfLErqcGYkLClee +V+Y+ +++ ++ +s +e++++++l+pe+ LE+ +GY+LCl + I18RA_MOUS 410 FVSYSNWssPETDAVGSLSEEHLALNLFPEV---LEDTYGYRLCLLD 453 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+ PG+ +ad +i+++IkkSRr i++LSp++l+ + +El++A+++ I18RA_MOUS 454 RDVTPGGVYAD-DIVSIIKKSRRGIFILSPSYLNGP---RVFELQAAVNL 499 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt aL++++ k+ILI+++++++++ slp +++++ rvl ++++W+g I18RA_MOUS 500 ALVDQTLKLILIKFCSFQEPE---SLPYLVKKALRVL---PTVTWKGL-- 541 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +s+ ++srFW++ ry+mP+k s++ +++ I18RA_MOUS 542 -KSVHASSRFWTQIRYHMPVKN---------------SNRFMFNG 570 TLR2_CRIGR: domain 1 of 1, from 641 to 784: score 201.0, E = 1.8e-55 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s ++d++wv+n++++ l + ++++kLCl++RD TLR2_CRIGR 641 YDAFV-----SYS-EQDSYWVENLMVQQL---ENSEPPFKLCLHKRD 678 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS++f++s+ wc++El+++++r++ TLR2_CRIGR 679 FVPGKWIID-NIIDSIEKSHKTLFVLSENFVRSE--WCKYELDFSHFRLF 725 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ IL++lep+++++ +p+++++Lr++++++tyl+Wp D TLR2_CRIGR 726 DENNDAGILVLLEPIEKKA----IPQRFCKLRKIMNTKTYLEWPLD---- 767 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + +++ FW +Lr+a+ TLR2_CRIGR 768 -EGQQEVFWVNLRTAI-------------------------KS 784 SIGIR_HUMAN: domain 1 of 1, from 165 to 315: score 198.4, E = 1.1e-54 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++Y+ s+s++++++++vn++L+++ LEr++GYkL+l +RD SIGIR_HUMA 165 YDAYV-----SYSDCPEDRKFVNFILKPQ---LERRRGYKLFLDDRD 203 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +lP++++ + +++ +++++RrlivVLS++fl++ wc +++ +l+r+L SIGIR_HUMA 204 LLPRAEPSA-DLLVNLSRCRRLIVVLSDAFLSRA--WCSHSFREGLCRLL 250 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e+++++I+I++e +++ + +++l++Lr++++++t l+W+++ SIGIR_HUMA 251 -ELTRRPIFITFEGQRRDP----AHPALRLLRQHRHLVTLLLWRPG---- 291 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* s++p+s+FWk+++ a+ ++k+++++ SIGIR_HUMA 292 SVTPSSDFWKEVQLAL-------------------PRKVQYRP 315 TLR21_CHICK: domain 1 of 1, from 650 to 793: score 194.9, E = 1.2e-53 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s + d+ wv+n +++ l + ++++LCl++RD TLR21_CHIC 650 YDAFV-----SYS-ENDSNWVENIMVQQL---EQACPPFRLCLHKRD 687 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS+hf++s+ wc++El+++++r++ TLR21_CHIC 688 FVPGKWIVD-NIIDSIEKSHKTLFVLSEHFVQSE--WCKYELDFSHFRLF 734 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep++ + +p+++++Lr++++++tyl+Wp+D TLR21_CHIC 735 DENNDVAILILLEPIQSQA----IPKRFCKLRKIMNTKTYLEWPPD---- 776 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++ FW +L++a+ TLR21_CHIC 777 -EEQQQMFWENLKAAL-------------------------KS 793 TLR22_CHICK: domain 1 of 1, from 638 to 781: score 194.9, E = 1.2e-53 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ s+s + d+ wv+n +++ l + ++++LCl++RD TLR22_CHIC 638 YDAFV-----SYS-ENDSNWVENIMVQQL---EQACPPFRLCLHKRD 675 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG++++d ni++sI+kS+++++VLS+hf++s+ wc++El+++++r++ TLR22_CHIC 676 FVPGKWIVD-NIIDSIEKSHKTLFVLSEHFVQSE--WCKYELDFSHFRLF 722 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted +enn++ ILI+lep++ + +p+++++Lr++++++tyl+Wp+D TLR22_CHIC 723 DENNDVAILILLEPIQSQA----IPKRFCKLRKIMNTKTYLEWPPD---- 764 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++ FW +L++a+ TLR22_CHIC 765 -EEQQQMFWENLKAAL-------------------------KS 781 TLR12_MOUSE: domain 1 of 1, from 761 to 905: score 194.7, E = 1.4e-53 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++++ +++++d+ wv++elLp l+gfL+ G++LCl+eRD TLR12_MOUS 761 FDVFV------SHCRQDQGWVIEELLPALEGFLPAGLGLRLCLPERD 801 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f PG++v+d n+++s+ +SR++++VLS + l+++ +c++El++A++++L TLR12_MOUS 802 FEPGKDVVD-NVVDSMLSSRTTLCVLSGQALCNP--RCRLELRLATSLLL 848 i.ennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte + ++++++ L++lep+s+++l+g ++rL r+l+r++y++Wp++ TLR12_MOUS 849 AaPSPPVLLLVFLEPISRHQLPG-----YHRLARLLRRGDYCLWPEE--- 890 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +++ks+FW++Lr +++ TLR12_MOUS 891 --EERKSGFWTWLR---------------------------SRL 905 TLR9_CANLF: domain 1 of 1, from 873 to 1028: score 192.3, E = 7.1e-53 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErq..cGYkLClee +V++ ++qs++ dwv+nel+ l +Er++++ ++LClee TLR9_CANLF 873 FVVFD------KAQSSVADWVYNELRVQL---EERRgrRALRLCLEE 910 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD++PG++ ++ n+++s+++SR++++VL+++ + sg + ++ +A++r TLR9_CANLF 911 RDWVPGKTLFE-NLWASVYSSRKTLFVLARTDRVSG--LLRASFLLAQQR 957 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l+p ++s +++r++qrL+r++ +l+Wp TLR9_CANLF 958 LLEDRKDVVVLVILCPDAHRS---RYVRLRQRLCRQS----VLLWP---- 996 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++s++ FW++L +a+ +++n+++ ++++++++ TLR9_CANLF 997 -HQPSGQRSFWAQLGTAL----TRDNRHF--------YNQNFCRG 1028 TLR9_FELCA: domain 1 of 1, from 871 to 1026: score 188.6, E = 9.6e-52 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErq..cGYkLClee +V++ ++qs++ dwv+nel+ +l +Er++++ ++LClee TLR9_FELCA 871 FVVFD------KAQSAVADWVYNELRVRL---EERRgrRALRLCLEE 908 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+lPG++ ++ n+++s+++SR+ ++VL+++ + sg + ++ +A++r TLR9_FELCA 909 RDWLPGKTLFE-NLWASVYSSRKMLFVLAHTDRVSG--LLRASFLLAQQR 955 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l+p ++s +++r++qrL+r++ +l+Wp TLR9_FELCA 956 LLEDRKDVVVLVILRPDAHRS---RYVRLRQRLCRQS----VLLWP---- 994 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++s++ FW++L +a+ +++n ++ ++++++++ TLR9_FELCA 995 -HQPSGQRSFWAQLGTAL----TRDNQHF--------YNQNFCRG 1026 TLR9_PIG: domain 1 of 1, from 870 to 1025: score 187.6, E = 1.8e-51 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErq..cGYkLClee +V++ ++qs++ dwv+nel+ l +Er++++ ++LClee TLR9_PIG 870 FVVFD------KAQSAVADWVYNELRVQL---EERRgrRALRLCLEE 907 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+lPG++ ++ n+++s+++SR++++VL+++ + sg + ++ +A++r TLR9_PIG 908 RDWLPGKTLFE-NLWASVYSSRKTLFVLAHTDRVSG--LLRASFLLAQQR 954 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l+p +s +++r++qrL+r++ +l+Wp TLR9_PIG 955 LLEDRKDVVVLVILRPDAYRS---RYVRLRQRLCRQS----VLLWP---- 993 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++ +++ FW++L +a+ +++n ++ ++++++++ TLR9_PIG 994 -HQPRGQGSFWAQLGTAL----TRDNHHF--------YNRNFCRG 1025 TLR9_SHEEP: domain 1 of 1, from 869 to 1024: score 185.0, E = 1.1e-50 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErq..cGYkLClee +V++ ++qs++ dwv+nel+ l +Er++++ ++LClee TLR9_SHEEP 869 FVVFD------KAQSAVADWVYNELRVQL---EERRgrRALRLCLEE 906 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+lPG++ ++ n+++s+++SR++++VL ++ + sg + ++ +A++r TLR9_SHEEP 907 RDWLPGKTLFE-NLWASVYSSRKTMFVLDHTDRVSG--LLRASFLLAQQR 953 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l+p +s +++r++qrL+r++ +l+Wp TLR9_SHEEP 954 LLEDRKDVVVLVILRPAAYRS---RYVRLRQRLCRQS----VLLWP---- 992 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++s+++ FW++L a+ +++n+++ ++++++++ TLR9_SHEEP 993 -HQPSGQGSFWANLGMAL----TRDNRHF--------YNRNFCRG 1024 TLR9_HORSE: domain 1 of 1, from 871 to 1026: score 183.6, E = 3e-50 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErq..cGYkLClee +V++ ++qs++ dwv+nel+ +l +Er++++ ++LClee TLR9_HORSE 871 FVVFD------KAQSAVADWVYNELRVRL---EERRgrRALRLCLEE 908 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+lPG++ ++ n+++s+++SR+ ++VL+++ sg + ++ +A++r TLR9_HORSE 909 RDWLPGKTLFE-NLWASVYSSRKMLFVLAHTDQVSG--LLRASFLLAQQR 955 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l p ++s +++r++qrL+r++ +l+Wp TLR9_HORSE 956 LLEDRKDVVVLVILSPDARRS---RYVRLRQRLCRQS----VLFWP---- 994 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++s++ FW++L a+ +++n+++ ++++++++ TLR9_HORSE 995 -HQPSGQRSFWAQLGMAL----TRDNRHF--------YNQNFCRG 1026 TLR9_HUMAN: domain 1 of 1, from 873 to 1028: score 174.6, E = 1.5e-47 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLE..rqcGYkLClee +V++ ++qs++ dwv+nel+ l +E +++ ++LClee TLR9_HUMAN 873 FVVFD------KTQSAVADWVYNELRGQL---EEcrGRWALRLCLEE 910 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+lPG++ ++ n+++s+++SR++++VL+++ + sg + ++ +A++r TLR9_HUMAN 911 RDWLPGKTLFE-NLWASVYGSRKTLFVLAHTDRVSG--LLRASFLLAQQR 957 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l p ++s +++r++qrL+r++ +l+Wp TLR9_HUMAN 958 LLEDRKDVVVLVILSPDGRRS---RYVRLRQRLCRQS----VLLWP---- 996 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++s++ FW++L a+ +++n ++ ++++++ + TLR9_HUMAN 997 -HQPSGQRSFWAQLGMAL----TRDNHHF--------YNRNFCQG 1028 TLR13_MOUSE: domain 1 of 1, from 834 to 990: score 173.2, E = 4e-47 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLE.rqcGYkLCleeR Y++++ s+s + de wv+ el+p l + + q +kLCl+ R TLR13_MOUS 834 YDAFV-----SFS-ATDEAWVYKELVPAL---EQgSQTTFKLCLHQR 871 DflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhra Df PG ++++ niq +I+ SR++++V+S h+l+s+ wc++E ++A + TLR13_MOUS 872 DFEPGIDIFE-NIQNAINTSRKTLCVVSNHYLHSE--WCRLEVQLASMKM 918 LiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte + e+++++ILI+le + +y+ + s++rLr++ ++qt ++Wp TLR13_MOUS 919 FYEHKDVIILIFLEEIPNYK-----LSSYHRLRKLINKQTFITWP----- 958 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ds+ ++ FW++ r+a+ ke++++ ++++ + TLR13_MOUS 959 DSVHQQPLFWARIRNAL---GKETVEK---------ENTHLIVV 990 TLR9_BOVIN: domain 1 of 1, from 870 to 1024: score 172.4, E = 7.3e-47 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErq..cGYkLClee V++ + qs++ dwv+nel+ l +Er++++ ++LClee TLR9_BOVIN 870 -VVFD------KVQSAVADWVYNELRVQL---EERRgrRALRLCLEE 906 RDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhr RD+lPG++ ++ n+++s+++SR++++VL ++ + sg + ++ +A++r TLR9_BOVIN 907 RDWLPGKTLFE-NLWASVYSSRKTMFVLDHTDRVSG--LLRASFLLAQQR 953 aLiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFt +L++++++v+L++l+p +s +++r++qrL+r++ +l+Wp TLR9_BOVIN 954 LLEDRKDVVVLVILRPAAYRS---RYVRLRQRLCRQS----VLLWP---- 992 edsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++s+++ FW++L a+ +++n+++ ++++++++ TLR9_BOVIN 993 -HQPSGQGSFWANLGIAL----TRDNRHF--------YNRNFCRG 1024 TLR1_HUMAN: domain 1 of 1, from 640 to 784: score 164.1, E = 2.3e-44 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++Y+ +d+ wv nelLp+l + G + Cl+eR TLR1_HUMAN 640 FISYS---------GHDSFWVKNELLPNL-----EKEGMQICLHERN 672 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+ +++ ni+ I+kS + i+VLSp+f++s+ wc +El++A+h+++ TLR1_HUMAN 673 FVPGKSIVE-NIITCIEKSYKSIFVLSPNFVQSE--WCHYELYFAHHNLF 719 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e +ILI+lep+ +ys +p s+++L++++ r+tyl+Wp + TLR1_HUMAN 720 HEGSNSLILILLEPIPQYS----IPSSYHKLKSLMARRTYLEWP-----K 760 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +s ++ FW++Lr+a+ k + TLR1_HUMAN 761 EKSKRGLFWANLRAAI-------------------NIKLTEQA 784 TLR1_MOUSE: domain 1 of 1, from 643 to 792: score 157.9, E = 1.7e-42 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +V+Y+ +d+ wv nelLp+l + ++ + Cl+eR TLR1_MOUSE 643 FVSYS---------GHDSAWVKNELLPNL---EKDDI--QICLHERN 675 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+ +++ ni+ +I+kS + i+VLSphf++s+ wc +El++A+h+++ TLR1_MOUSE 676 FVPGKSIVE-NIINFIEKSYKSIFVLSPHFIQSE--WCHYELYFAHHNLF 722 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e +++ILI+l p+ +ys +p +++L+ +++r+tyl+Wp + TLR1_MOUSE 723 HEGSDNLILILLAPIPQYS----IPTNYHKLKTLMSRRTYLEWPTE---- 764 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++ + FW++Lr+ + + v ++ ++ + TLR1_MOUSE 765 -KNKHGLFWANLRASI--------------NVKLVNQAEGTCY 792 TLR6_MOUSE: domain 1 of 1, from 645 to 789: score 154.3, E = 2e-41 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +V+Y+ ++d+ wv nelLp+l + ++ + Cl+eR TLR6_MOUSE 645 FVSYS---------EHDSAWVKNELLPNL---EKDDIRV--CLHERN 677 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+ +++ ni+ +I+kS + i+VLSphf++s+ wc +El++A+h+++ TLR6_MOUSE 678 FVPGKSIVE-NIINFIEKSYKAIFVLSPHFIQSE--WCHYELYFAHHNLF 724 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e +++ILI+lep+ + +p ++++Lr ++ +tyl+Wp + TLR6_MOUSE 725 HEGSDNLILILLEPILQNN----IPSRYHKLRALMAQRTYLEWPTE---- 766 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* + ++ FW++Lr+ k l TLR6_MOUSE 767 -KGKRGLFWANLRASF-------------------IMKLALVN 789 IRL1B_DANRE: domain 1 of 1, from 408 to 592: score 150.1, E = 3.7e-40 *->YViYpkv.FpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeR YV+Y kv+ + + + ++e+++++e+Lp+ LE+ +GYkL++++R IRL1B_DANR 408 YVSYTKVdPDQWSQETREEEHFALEILPDM---LEKHYGYKLFIPDR 451 DflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhra D++P +++++ ++ + +S+rli+V +p+++ ++ w ++Ele l ++ IRL1B_DANR 452 DLIPTGTYIE-DVARCVDQSKRLIIVMTPNYVVRR-GWSIFELETRLRNM 499 LiennskvILIe...lepvsdysllgslprslqrLrrvlqrqtylkWpgD L+ +kvILIe ++l+ + +y+ + +++l++ ++l t+++Wpg IRL1B_DANR 500 LVSGEIKVILIEcsdLRGIMNYQ--E--VEALKHTIKLL---TVIRWPGP 542 FtedsqspksrFWkkLryamP............skpkeankpkdeseaqs s +p+srFWk+L+y mP ++++++ ++++++ +++ +p+ e IRL1B_DANR 543 ---GSSKPNSRFWKQLQYEMPfrrpepklsheqVLDASEQGPFGE----- 584 vsskkhllt<-* +++++ l IRL1B_DANR 585 -LQTVSALS 592 TLR6_DASNO: domain 1 of 1, from 644 to 788: score 146.5, E = 4.3e-39 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++Y+ +d+ wv elLp+l + + Cl+eR TLR6_DASNO 644 FISYS---------GHDSAWVKTELLPNL-----EKEDIQICLHERN 676 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+ +++ ni+ +I+kS + i+VLSp+f++s+ wc +El++A+h+++ TLR6_DASNO 677 FVPGKSIIE-NIINFIEKSYKSIFVLSPNFVQSE--WCHYELYFAHHNLF 723 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e +++ILI+lep+ +ys +p +++L+++ +tyl+Wp + TLR6_DASNO 724 HEAFDNLILILLEPIPQYS----IPNNYHKLKSLIAQRTYLEWP-----K 764 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +s + FW++Lr+a+ k TLR6_DASNO 765 EKSKHGLFWANLRAAI-------------------NIKLMEEK 788 TLR7_MOUSE: domain 1 of 1, from 892 to 1049: score 144.9, E = 1.3e-38 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLE.rqcGYkLCleeR Y++++ ++t+ s++++wv el+ l + +r++ ++LCleeR TLR7_MOUSE 892 YDAFI---VYDTKNSAVTEWVLQELVAKL---EDpREKHFNLCLEER 932 DflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhra D+lPG+ v + n+ +sI+ S+++++V ++++ k + ++ +++++++r+ TLR7_MOUSE 933 DWLPGQPVLE-NLSQSIQLSKKTVFVMTQKYAKTE--SFKMAFYLSHQRL 979 LiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte L+e +++ILI+le+ ++s + +++++rL+r + +l+Wp TLR7_MOUSE 980 LDEKVDVIILIFLEKPLQKS---KFLQLRKRLCRSS----VLEWP----- 1017 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++ FW+ L++a+ +++n + +s+ ++ t TLR7_MOUSE 1018 ANPQAHPYFWQCLKNAL----TTDNHVA--------YSQMFKET 1049 IRPL2_MOUSE: domain 1 of 1, from 402 to 577: score 144.6, E = 1.7e-38 *->YViYpkvFpsstsqskde..........dwvvnelLpeldgfLErqc Y++Y+ s++ d+++ + ++++++ +++e+Lp++ LE+ + IRPL2_MOUS 402 YDAYL-----SYT-KVDQdtldcdnteeEQFALEILPDV---LEKHY 439 GYkLCleeRDflPGeavadNniqesIkkSRrlivVLSphflksgllwclt GYkL+++eRD++P +++++ ++ +++SRrli+VL+p+++ ++ w ++ IRPL2_MOUS 440 GYKLFIPERDLIPSGTYIE-DLTRCVEQSRRLIIVLTPDYILRR-GWSIF 487 EleiAlhraLiennskvILIelepvsdysll.gslprslqrLrrvlqrqt Ele lh++L+ +kvILIe + ++ + ++ ++sl++ ++l IRPL2_MOUS 488 ELESRLHNMLVSGEIKVILIECTELKGKVNCqE--VESLKHNIKLL---S 532 ylkWpgDFtedsqspksrFWkkLryamPskpkeankpkdeseaqsvsskk +kW+g +s + +s+FWk+L y mP k+ke ++ ++v++++ IRPL2_MOUS 533 LIKWKGP---KSSKLNSKFWKHLVYEMPIKKKEMLSH------CHVLDSA 573 hllt<-* + + IRPL2_MOUS 574 EQGL 577 TLR7_HUMAN: domain 1 of 1, from 891 to 1048: score 142.1, E = 9.6e-38 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLE.rqcGYkLCleeR Y++++ ++t++ ++++wv el+ l + +r++ ++LCleeR TLR7_HUMAN 891 YDAFI---VYDTKDPAVTEWVLAELVAKL---EDpREKHFNLCLEER 931 DflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhra D+lPG+ v + n+ +sI+ S+++++V ++++ k + +++ +++++++r+ TLR7_HUMAN 932 DWLPGQPVLE-NLSQSIQLSKKTVFVMTDKYAKTE--NFKIAFYLSHQRL 978 LiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte ++e +++ILI+le+ ++s + +++++rL++ + +l+Wp TLR7_HUMAN 979 MDEKVDVIILIFLEKPFQKS---KFLQLRKRLCGSS----VLEWP----- 1016 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++ FW+ L++a+ +++n + +s++++ t TLR7_HUMAN 1017 TNPQAHPYFWQCLKNAL----ATDNHVA--------YSQVFKET 1048 TLR6_BOVIN: domain 1 of 1, from 645 to 789: score 139.1, E = 7.3e-37 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++Y+ ++d+ wv nel p+l + + Cl+eR TLR6_BOVIN 645 FISYS---------EHDSAWVKNELIPNL-----EKEDIRICLHERN 677 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+ G+ +++ ni+ I+kS + i+VLSp+f++s+ wc +El++A+h+++ TLR6_BOVIN 678 FVAGKSIVE-NIINCIEKSYKSIFVLSPNFVQSE--WCHYELYFAHHNLF 724 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e +++ILI+l p+ +ys +p s+++Lr ++ +tyl+Wp + TLR6_BOVIN 725 HEGSDNLILILLDPIPQYS----IPSSYHKLRALMAQRTYLEWP-----K 765 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +s + FW++Lr+ + k + TLR6_BOVIN 766 EKSKHGLFWANLRASI-------------------NIKLMEKA 789 IRPL2_HUMAN: domain 1 of 1, from 402 to 577: score 136.7, E = 3.9e-36 *->YViYpkvFpssts.........qskdedwvvnelLpeldgfLErqcG Y++Y+ s+++ ++++ + ++++e+ +++e Lp++ LE+ +G IRPL2_HUMA 402 YDAYL-----SYTkvdqdtldcDNPEEEQFALEVLPDV---LEKHYG 440 YkLCleeRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltE YkL+++eRD++P +++ + ++ +++SRrli+VL+p+++ ++ w ++E IRPL2_HUMA 441 YKLFIPERDLIPSGTYME-DLTRYVEQSRRLIIVLTPDYILRR-GWSIFE 488 leiAlhraLiennskvILIelepvsdysll.gslprslqrLrrvlqrqty le lh++L+ +kvILIe + ++ + ++ ++sl+r ++l IRPL2_HUMA 489 LESRLHNMLVSGEIKVILIECTELKGKVNCqE--VESLKRSIKLL---SL 533 lkWpgDFtedsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkh +kW+g +s + +s+FWk+L y mP k+ke + ++v++++ IRPL2_HUMA 534 IKWKGS---KSSKLNSKFWKHLVYEMPIKKKEML------PRCHVLDSAE 574 llt<-* + + IRPL2_HUMA 575 QGL 577 TLR6_HUMAN: domain 1 of 1, from 645 to 789: score 136.2, E = 5.4e-36 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++Y+ ++d+ wv el+p l + + Cl+eR TLR6_HUMAN 645 FISYS---------EHDSAWVKSELVPYL-----EKEDIQICLHERN 677 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f+PG+ +++ ni+ I+kS + i+VLSp+f++s+ wc +El++A+h+++ TLR6_HUMAN 678 FVPGKSIVE-NIINCIEKSYKSIFVLSPNFVQSE--WCHYELYFAHHNLF 724 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e ++ILI+lep+ + s +p ++++L+ ++ +tyl+Wp + TLR6_HUMAN 725 HEGSNNLILILLEPIPQNS----IPNKYHKLKALMTQRTYLQWP-----K 765 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +s ++ FW++ r+a k l t TLR6_HUMAN 766 EKSKRGLFWANIRAAF-------------------NMKLTLVT 789 TLR10_HUMAN: domain 1 of 1, from 637 to 799: score 133.3, E = 4.2e-35 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++Y+ ++d+ wv nel p+l + + Cl+e TLR10_HUMA 637 FISYS---------EHDSLWVKNELIPNL---EKEDGSILICLYESY 671 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f PG+ + + ni+++I+kS + i+VLSp+f++++ wc +E+++A+h+++ TLR10_HUMA 672 FDPGKSISE-NIVSFIEKSYKSIFVLSPNFVQNE--WCHYEFYFAHHNLF 718 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted en + +ILI+lep+ y +p ++++L+ +l ++ yl+Wp + TLR10_HUMA 719 HENSDHIILILLEPIPFYC----IPTRYHKLKALLEKKAYLEWP-----K 759 sqspksrFWkkLryamPskpkeankpkdes.eaqsvsskkhllt<-* ++ + FW++Lr+a+ ++ +++e e+q+ ++ ++ TLR10_HUMA 760 DRRKCGLFWANLRAAI----NVNVLATREMyELQTFTELNEESR 799 IRL1A_DANRE: domain 1 of 1, from 412 to 595: score 129.1, E = 7.9e-34 *->YViYpkv.FpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeR Y +Y+kv+ + + ++e+ +++e+Lp++ LE+ +GYkL++++R IRL1A_DANR 412 YLSYSKVeLDQWGQELQEEERFALEILPDV---LEKHYGYKLFIPDR 455 DflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhra D++P ++++ ++ + S+rli+VL+p+++ ++ w ++Ele l + IRL1A_DANR 456 DLIPTSTYIE-DVSRCVDMSKRLIIVLTPSYVLRR-GWSIFELESRLRNS 503 LiennskvILIe...lepvsdysllgslprslqrLrrvlqrqtylkWpgD L+ ++kvILIe +l+ v +y+ ++ q ++ ++ ++ W g IRL1A_DANR 504 LVSGDIKVILIEcadLRGVINYQ---EVEELKQSIKCLS----VVHWNGP 546 FtedsqspksrFWkkLryamP...........skpkeankpkdeseaqsv +s +p srFWk+Lry mP ++++++ +++ + +++ +p++ IRL1A_DANR 547 ---QSNKPGSRFWKQLRYTMPyrrpqqtitnhALDTSEPGPFAD------ 587 sskkhllt<-* +++++ + IRL1A_DANR 588 LQTVSAIS 595 IRPL1_PONPY: domain 1 of 1, from 405 to 591: score 127.8, E = 1.9e-33 *->YViYpkvFpsstsqskde........dwvvnelLpeldgfLErqcGY Y++Y+ s t+ +d+ ++++++++ +++e+Lp+ LE+ +GY IRPL1_PONP 405 YDAYL----SYTKVDPDQwnqetgeeERFALEILPDM---LEKHYGY 444 kLCleeRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEl kL++++RD++P +++++ ++ + +S+rli+V +p+++ ++ w ++El IRPL1_PONP 445 KLFIPDRDLIPTGTYIE-DVARCVDQSKRLIIVMTPNYVVRR-GWSIFEL 492 eiAlhraLiennskvILI...elepvsdysllgslprslqrLrrvlqrqt e l ++L+ +kvILI+ +el+ + +y+ + +++l++ ++l t IRPL1_PONP 493 ETRLRNMLVTGEIKVILIecsELRGIMNYQ--E--VEALKHTIKLL---T 535 ylkWpgDFtedsqspksrFWkkLryamP...........skpkeankpkd ++kW+g + + +s+FWk+L+y mP ++ ++ ++++ + ++ +p+ IRPL1_PONP 536 VIKWHGP---KCNKLNSKFWKRLQYEMPfkriepitheqALDVSEQGPFG 582 eseaqsvsskkhllt<-* e +++++ + IRPL1_PONP 583 E------LQTVSAIS 591 IRPL1_PANTR: domain 1 of 1, from 405 to 591: score 127.8, E = 1.9e-33 *->YViYpkvFpsstsqskde........dwvvnelLpeldgfLErqcGY Y++Y+ s t+ +d+ ++++++++ +++e+Lp+ LE+ +GY IRPL1_PANT 405 YDAYL----SYTKVDPDQwnqetgeeERFALEILPDM---LEKHYGY 444 kLCleeRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEl kL++++RD++P +++++ ++ + +S+rli+V +p+++ ++ w ++El IRPL1_PANT 445 KLFIPDRDLIPTGTYIE-DVARCVDQSKRLIIVMTPNYVVRR-GWSIFEL 492 eiAlhraLiennskvILI...elepvsdysllgslprslqrLrrvlqrqt e l ++L+ +kvILI+ +el+ + +y+ + +++l++ ++l t IRPL1_PANT 493 ETRLRNMLVTGEIKVILIecsELRGIMNYQ--E--VEALKHTIKLL---T 535 ylkWpgDFtedsqspksrFWkkLryamP...........skpkeankpkd ++kW+g + + +s+FWk+L+y mP ++ ++ ++++ + ++ +p+ IRPL1_PANT 536 VIKWHGP---KCNKLNSKFWKRLQYEMPfkriepitheqALDVSEQGPFG 582 eseaqsvsskkhllt<-* e +++++ + IRPL1_PANT 583 E------LQTVSAIS 591 IRPL1_HUMAN: domain 1 of 1, from 405 to 591: score 127.8, E = 1.9e-33 *->YViYpkvFpsstsqskde........dwvvnelLpeldgfLErqcGY Y++Y+ s t+ +d+ ++++++++ +++e+Lp+ LE+ +GY IRPL1_HUMA 405 YDAYL----SYTKVDPDQwnqetgeeERFALEILPDM---LEKHYGY 444 kLCleeRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEl kL++++RD++P +++++ ++ + +S+rli+V +p+++ ++ w ++El IRPL1_HUMA 445 KLFIPDRDLIPTGTYIE-DVARCVDQSKRLIIVMTPNYVVRR-GWSIFEL 492 eiAlhraLiennskvILI...elepvsdysllgslprslqrLrrvlqrqt e l ++L+ +kvILI+ +el+ + +y+ + +++l++ ++l t IRPL1_HUMA 493 ETRLRNMLVTGEIKVILIecsELRGIMNYQ--E--VEALKHTIKLL---T 535 ylkWpgDFtedsqspksrFWkkLryamP...........skpkeankpkd ++kW+g + + +s+FWk+L+y mP ++ ++ ++++ + ++ +p+ IRPL1_HUMA 536 VIKWHGP---KCNKLNSKFWKRLQYEMPfkriepitheqALDVSEQGPFG 582 eseaqsvsskkhllt<-* e +++++ + IRPL1_HUMA 583 E------LQTVSAIS 591 IRPL1_RAT: domain 1 of 1, from 405 to 591: score 127.8, E = 1.9e-33 *->YViYpkvFpsstsqskde........dwvvnelLpeldgfLErqcGY Y++Y+ s t+ +d+ ++++++++ +++e+Lp+ LE+ +GY IRPL1_RAT 405 YDAYL----SYTKVDPDQwnqetgeeERFALEILPDM---LEKHYGY 444 kLCleeRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEl kL++++RD++P +++++ ++ + +S+rli+V +p+++ ++ w ++El IRPL1_RAT 445 KLFIPDRDLIPTGTYIE-DVARCVDQSKRLIIVMTPNYVVRR-GWSIFEL 492 eiAlhraLiennskvILI...elepvsdysllgslprslqrLrrvlqrqt e l ++L+ +kvILI+ +el+ + +y+ + +++l++ ++l t IRPL1_RAT 493 ETRLRNMLVTGEIKVILIecsELRGIMNYQ--E--VEALKHTIKLL---T 535 ylkWpgDFtedsqspksrFWkkLryamP...........skpkeankpkd ++kW+g + + +s+FWk+L+y mP ++ ++ ++++ + ++ +p+ IRPL1_RAT 536 VIKWHGP---KCNKLNSKFWKRLQYEMPfkriepitheqALDVSEQGPFG 582 eseaqsvsskkhllt<-* e +++++ + IRPL1_RAT 583 E------LQTVSAIS 591 TOLL8_DROME: domain 1 of 1, from 1076 to 1221: score 119.6, E = 5.7e-31 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++++ s+s skde v +el p l + ++ +YkLCl+ RD TOLL8_DROM 1076 FDAFV-----SYS-SKDELFVNEELAPML---EMGEHRYKLCLHQRD 1113 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f G+ + i+++I +SRr+i V+S++f+ks+ wc++E++ A+++ L TOLL8_DROM 1114 FPVGGYLPE-TIVQAIDSSRRTIMVVSENFIKSE--WCRFEFKSAHQSVL 1160 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted ++++++I I+l+ v +++ + Lr +l+++tyl+W D TOLL8_DROM 1161 RDRRRRLIVIVLGEVPQKE-------LDPDLRLYLKTNTYLQWG-D---- 1198 sqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* FW+kLr a+P+ + ss++++ + TOLL8_DROM 1199 -----KLFWQKLRFALPDVS---------------SSQRSNVA 1221 TOLL_DROME: domain 1 of 1, from 859 to 1029: score 118.8, E = 9.9e-31 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++++ s+s kd+ + l+p l +++ ++LC +eRD TOLL_DROME 859 FDAFI-----SYS-HKDQSFIEDYLVPQL---EHGPQKFQLCVHERD 896 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL +l G+ + + ni+ s+ SRr+i+VLS++f+ks+ w+++E+++A+ +aL TOLL_DROME 897 WLVGGHIPE-NIMRSVADSRRTIIVLSQNFIKSE--WARLEFRAAHRSAL 943 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e +s++I I++ + d + ++ ++L+ +l+ +tylkW D TOLL_DROME 944 NEGRSRIIVIIYSDIGDVE------KLDEELKAYLKMNTYLKWG-D---- 982 sqspksrFWkkLryamP...........skpkeankpkdeseaqsvsskk +FW+kLr a+P++++ ++ +++ ++k+a k + +++ + k TOLL_DROME 983 -----PWFWDKLRFALPhrrpvgnigngALIKTALKGSTDDKLE--LIKP 1025 hllt<-* + t TOLL_DROME 1026 SPVT 1029 IRPL1_MOUSE: domain 1 of 1, from 405 to 590: score 117.8, E = 1.9e-30 *->YViYpkvFpsstsqskde........dwvvnelLpeldgfLErqcGY Y++Y+ s t+ +d+ ++++++++ +++e+Lp+ LE+ +GY IRPL1_MOUS 405 YDAYL----SYTKVDPDQwnqetgeeERFALEILPDM---LEKHYGY 444 kLCleeRDflPGeavadNniqesIkkSRrlivVLSphflksgllwcltEl kL++++RD++P +++ d + + +S+rli+V +p+++ ++ w ++El IRPL1_MOUS 445 KLFIPDRDLIPTGNIED--VARCVDQSKRLIIVMTPNYVVRR-GWSIFEL 491 eiAlhraLiennskvILI...elepvsdysllgslprslqrLrrvlqrqt e l ++L+ +kvILI+ +el+ + +y+ + +++l++ ++l t IRPL1_MOUS 492 ETRLRNMLVTGEIKVILIecsELRGIMNYQ--E--VEALKHTIKLL---T 534 ylkWpgDFtedsqspksrFWkkLryamP...........skpkeankpkd ++kW+g + + +s+FWk+L+y mP ++ ++ ++++ + ++ +p+ IRPL1_MOUS 535 VIKWHGP---KCNKLNSKFWKRLQYEMPfkriepitheqALDVSEQGPFG 581 eseaqsvsskkhllt<-* e +++++ + IRPL1_MOUS 582 E------LQTVSAIS 590 TLR10_BOVIN: domain 1 of 1, from 638 to 788: score 102.1, E = 1.1e-25 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD +++Y+ ++d+ wv el p l + + Cl+e TLR10_BOVI 638 FISYS---------EHDSAWVKYELIPSL---EKEDGSVLICLHEGN 672 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL PG+ ++ +++ I+kS + i+VLSp+f++ + wc +E ++A+h+++ TLR10_BOVI 673 SDPGKSMTE-DTINCIEKSYKSIFVLSPSFVQTE--WCHYEPYFAHHNLF 719 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted e+ + +ILI+lep+ y +p ++ +L+ ++ ++ yl+Wp + TLR10_BOVI 720 HESLDYIILILLEPIPLYC----IPTRYPELKALMEKKAYLEWP-----K 760 sqspksrFWkkLryamPskpkeankpkdeseaqsv..sskkhllt<-* ++ + FW++Lr+a+ +v+ ++++++ TLR10_BOVI 761 DRRKCGLFWANLRAAL-----------------HVnlLDTRGTCE 788 TOLL6_DROME: domain 1 of 1, from 1114 to 1269: score 73.3, E = 4.7e-17 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD ++Y+ ++ s ++++vn++L LE++ GY+LCl++RD TOLL6_DROM 1114 -DAYF------AY-SLQDEHFVNQILAQT---LENDIGYRLCLHYRD 1149 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL + + ++d ++e+ ++ + + VLS++fl ++ w ++E++ Alh++ TOLL6_DROM 1150 VNINAYITD-ALIEAAESAKQFVLVLSKNFLYNE--WSRFEYKSALHELV 1196 iennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFted ++ +v++I+++ + +++ + + ++ r + t ++W+ D TOLL6_DROM 1197 -KRRKRVVFILYGDLPQRD----IDMDMRHYLRTS---TCIEWD-D---- 1233 sqspksrFWkkLryamP.............skpkeankpkdeseaqsvss +FW+kLr a+P ++++++++++ s + +s TOLL6_DROM 1234 -----KKFWQKLRLALPlpngrgnnnkrvvSGC---------------LS 1263 kkhllt<-* + ++ TOLL6_DROM 1264 GRTPSV 1269 TLR11_MOUSE: domain 1 of 1, from 774 to 926: score 59.6, E = 6.4e-13 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y++++ ++++ d+ wv +el+p l+ + G++LCl+ RD TLR11_MOUS 774 YDVFI------SYCEEDQAWVLEELVPVLEKAPPEGEGLRLCLPARD 814 flPGeavadNniqesIkkSRrlivVLSphflksgllwcltEleiAlhraL f G + + ++s+ kSR +++VL+ + l s+ wc +El++A++ + TLR11_MOUS 815 FGIGNDRME-SMIASMGKSRATLCVLTGQALASP--WCNLELRLATYHLV 861 i.ennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte +++ + + L +lep+++ ++s++rL r lq+ +y + TLR11_MOUS 862 ArPGTTHLLLLFLEPLDRQR-----LHSYHRLSRWLQKEDYFDLSQG--- 903 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* +++ +s F +L+ + s + + + TLR11_MOUS 904 -KVEWNS-FCEQLKRRL-------------------SKAGQERD 926 TLR3_MOUSE: domain 1 of 1, from 757 to 905: score 53.4, E = 4.7e-11 *->YViYpkvFpsstsqskdedwvvnelLpeldgfLErqcGYkLCleeRD Y +Y+ ++ kd dwv ++ + + +E + +k CleeRD TLR3_MOUSE 757 YTAYI-----IHA-HKDRDWVWEH-FSPM---EEQDQSLKFCLEERD 793 flPGeavadNniqesIkkSRrlivVLSphflksgllwcl.tEleiAlhra f G+ + i+ sIk+SR++i+V ++h lk++ c+++ A++ a TLR3_MOUSE 794 FEAGVLGLE-AIVNSIKRSRKIIFVITHHLLKDP--LCRrFKVHHAVQQA 840 LiennskvILIelepvsdysllgslprslqrLrrvlqrqtylkWpgDFte ++n + +ILI+l+ + dy+ l ++l++ r+ + +l Wp TLR3_MOUSE 841 IEQNLDSIILIFLQNIPDYK----LNHALCLRRGMFKSHCILNWP----- 881 dsqspksrFWkkLryamPskpkeankpkdeseaqsvsskkhllt<-* ++++ F +kL++a+ ++++ TLR3_MOUSE 882 VQKERINAFHHKLQVAL--------------------GSRNSAH 905 Histogram of all scores: score obs exp (one = represents 323 sequences) ----- --- --- -239 1 0|= -238 0 0| -237 5 0|= -236 6 0|= -235 9 0|= -234 8 0|= -233 10 0|= -232 11 0|= -231 22 0|= -230 32 0|= -229 47 0|= -228 65 0|= -227 94 0|= -226 123 0|= -225 179 0|= -224 212 0|= -223 188 0|= -222 230 0|= -221 131 0|= -220 235 0|= -219 214 0|= -218 142 0|= -217 137 0|= -216 129 0|= -215 157 0|= -214 158 0|= -213 188 0|= -212 119 0|= -211 137 0|= -210 130 0|= -209 142 0|= -208 144 0|= -207 129 0|= -206 145 0|= -205 129 0|= -204 144 0|= -203 151 0|= -202 158 0|= -201 137 0|= -200 136 0|= -199 141 0|= -198 147 0|= -197 160 0|= -196 172 0|= -195 267 0|= -194 197 0|= -193 216 0|= -192 273 0|= -191 224 0|= -190 247 0|= -189 284 0|= -188 226 0|= -187 247 0|= -186 232 0|= -185 280 0|= -184 313 0|= -183 413 0|== -182 583 0|== -181 439 0|== -180 492 0|== -179 444 0|== -178 368 0|== -177 401 0|== -176 459 0|== -175 325 0|== -174 388 0|== -173 484 0|== -172 374 0|== -171 464 0|== -170 450 0|== -169 603 0|== -168 611 0|== -167 656 0|=== -166 743 0|=== -165 652 0|=== -164 709 0|=== -163 777 0|=== -162 814 0|=== -161 844 0|=== -160 923 0|=== -159 993 0|==== -158 1043 0|==== -157 1021 0|==== -156 1031 0|==== -155 1175 0|==== -154 1140 0|==== -153 1200 0|==== -152 1245 0|==== -151 1297 0|===== -150 1402 0|===== -149 1470 0|===== -148 1491 0|===== -147 1555 0|===== -146 1821 0|====== -145 1916 0|====== -144 2063 0|======= -143 2139 0|======= -142 2230 0|======= -141 2457 0|======== -140 2681 0|========= -139 3020 0|========== -138 3221 0|========== -137 3440 0|=========== -136 3862 0|============ -135 3933 0|============= -134 4283 0|============== -133 4444 0|============== -132 4951 0|================ -131 5553 0|================== -130 6012 1|*================== -129 6733 8|*==================== -128 7297 42|*====================== -127 8572 169|*========================== -126 9366 530|=*=========================== -125 9734 1354|====*========================== -124 11057 2919|=========*========================= -123 11736 5445|================*==================== -122 12841 8986|===========================*============ -121 14017 13368|=========================================*== -120 14617 18216|============================================== * -119 15568 23046|================================================= * -118 16655 27383|==================================================== * -117 17141 30853|====================================================== * -116 18008 33237|======================================================== * -115 18200 34474|========================================================= * -114 18694 34629|==========================================================* -113 19006 33855|==========================================================* -112 18645 32351|==========================================================* -111 18194 30323|========================================================= * -110 17788 27961|======================================================== * -109 17469 25431|======================================================= * -108 16261 22863|=================================================== * -107 15725 20353|================================================= * -106 14467 17969|============================================= * -105 13549 15753|========================================== * -104 12384 13730|======================================= * -103 11252 11907|=================================== * -102 9986 10282|===============================* -101 9214 8848|===========================*= -100 8290 7591|=======================*== -99 7170 6496|====================*== -98 6463 5547|=================*=== -97 5818 4728|==============*==== -96 4877 4024|============*=== -95 4280 3420|==========*=== -94 3429 2904|========*== -93 3081 2463|=======*== -92 2396 2088|======*= -91 2203 1768|=====*= -90 1675 1497|====*= -89 1431 1267|===*= -88 1238 1072|===* -87 1014 906|==*= -86 840 766|==* -85 614 647|==* -84 455 547|=* -83 399 462|=* -82 308 390|=* -81 254 329|=* -80 190 278|* -79 150 235|* -78 108 198|* -77 74 167|* -76 59 141|* -75 43 119|* -74 51 100|* -73 25 85|* -72 14 71|* -71 28 60|* -70 15 51|* -69 11 43|* -68 12 36|* -67 7 30|* -66 1 26|* -65 2 21|* -64 3 18|* -63 2 15|* -62 0 13|* -61 3 11|* -60 0 9|* -59 0 7|* -58 1 6|* -57 2 5|* -56 2 4|* -55 2 4|* -54 5 3|* -53 0 2|* -52 1 2|* -51 0 2|* -50 2 1|* -49 1 1|* -48 1 1|* > -47 121 -|= % Statistical details of theoretical EVD fit: mu = -113.8597 lambda = 0.1695 chi-sq statistic = 7462531.0000 P(chi-square) = 0 Total sequences searched: 557012 Whole sequence top hits: tophits_s report: Total hits: 92 Satisfying E cutoff: 92 Total memory: 28K Domain top hits: tophits_s report: Total hits: 94 Satisfying E cutoff: 94 Total memory: 94K