Analysis Type: PANTHER Overrepresentation Test (Released 20240807) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.15066566 Released 2025-03-16 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: BONFERRONI Bonferroni count: 9152 GO biological process complete Homo sapiens - REFLIST (20580) upload_1 (83) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (P-value) carbohydrate derivative metabolic process (GO:1901135) 895 76 3.61 + 21.06 4.08E-92 carbohydrate derivative biosynthetic process (GO:1901137) 556 69 2.24 + 30.77 1.44E-91 glycosylation (GO:0070085) 238 58 .96 + 60.43 2.02E-91 protein glycosylation (GO:0006486) 218 52 .88 + 59.14 1.20E-79 macromolecule glycosylation (GO:0043413) 218 52 .88 + 59.14 1.20E-79 glycoprotein metabolic process (GO:0009100) 348 55 1.40 + 39.19 2.62E-74 glycoprotein biosynthetic process (GO:0009101) 281 52 1.13 + 45.88 2.90E-73 dolichol-linked oligosaccharide biosynthetic process (GO:0006488) 22 22 .09 + > 100 9.15E-51 protein N-linked glycosylation (GO:0006487) 74 30 .30 + > 100 1.43E-50 nucleotide-sugar biosynthetic process (GO:0009226) 30 24 .12 + > 100 4.63E-50 nucleotide-sugar metabolic process (GO:0009225) 45 25 .18 + > 100 6.82E-46 protein N-linked glycosylation via asparagine (GO:0018279) 43 24 .17 + > 100 6.02E-44 carbohydrate metabolic process (GO:0005975) 442 37 1.78 + 20.76 8.22E-36 biosynthetic process (GO:0009058) 3997 70 16.12 + 4.34 2.96E-33 protein modification process (GO:0036211) 1739 53 7.01 + 7.56 1.63E-32 glycolipid metabolic process (GO:0006664) 107 24 .43 + 55.62 3.15E-32 liposaccharide metabolic process (GO:1903509) 108 24 .44 + 55.10 4.04E-32 oligosaccharide metabolic process (GO:0009311) 64 21 .26 + 81.36 1.10E-31 ganglioside metabolic process (GO:0001573) 29 17 .12 + > 100 1.57E-30 macromolecule modification (GO:0043412) 1926 53 7.77 + 6.82 2.95E-30 primary metabolic process (GO:0044238) 6778 78 27.34 + 2.85 6.70E-28 glycosphingolipid metabolic process (GO:0006687) 64 19 .26 + 73.61 2.43E-27 metabolic process (GO:0008152) 7642 80 30.82 + 2.60 6.34E-27 organophosphate biosynthetic process (GO:0090407) 567 33 2.29 + 14.43 5.06E-26 glycolipid biosynthetic process (GO:0009247) 78 19 .31 + 60.40 1.79E-25 membrane lipid metabolic process (GO:0006643) 208 24 .84 + 28.61 8.30E-25 amino sugar metabolic process (GO:0006040) 43 16 .17 + 92.26 2.35E-24 amide metabolic process (GO:0043603) 412 28 1.66 + 16.85 3.76E-23 protein metabolic process (GO:0019538) 3342 57 13.48 + 4.23 1.73E-22 ganglioside biosynthetic process (GO:0001574) 17 12 .07 + > 100 4.49E-22 N-acetylneuraminate metabolic process (GO:0006054) 13 11 .05 + > 100 1.63E-21 nucleoside phosphate biosynthetic process (GO:1901293) 299 24 1.21 + 19.90 6.01E-21 glycosphingolipid biosynthetic process (GO:0006688) 39 14 .16 + 89.01 1.21E-20 macromolecule biosynthetic process (GO:0009059) 2937 52 11.85 + 4.39 3.99E-20 membrane lipid biosynthetic process (GO:0046467) 145 19 .58 + 32.49 6.10E-20 GDP-mannose metabolic process (GO:0019673) 11 10 .04 + > 100 6.51E-20 organophosphate metabolic process (GO:0019637) 977 34 3.94 + 8.63 1.23E-19 ceramide metabolic process (GO:0006672) 99 17 .40 + 42.58 1.35E-19 sphingolipid metabolic process (GO:0006665) 162 19 .65 + 29.08 5.45E-19 amino sugar biosynthetic process (GO:0046349) 13 10 .05 + > 100 1.68E-18 small molecule metabolic process (GO:0044281) 1576 39 6.36 + 6.14 4.64E-18 nucleoside phosphate metabolic process (GO:0006753) 582 27 2.35 + 11.50 9.08E-18 sialylation (GO:0097503) 10 9 .04 + > 100 1.65E-17 nucleobase-containing small molecule metabolic process (GO:0055086) 609 27 2.46 + 10.99 2.95E-17 lipid biosynthetic process (GO:0008610) 589 26 2.38 + 10.95 2.09E-16 phosphate-containing compound metabolic process (GO:0006796) 1427 34 5.76 + 5.91 1.94E-14 phosphorus metabolic process (GO:0006793) 1430 34 5.77 + 5.90 2.07E-14 ceramide biosynthetic process (GO:0046513) 58 12 .23 + 51.30 5.68E-14 sphingolipid biosynthetic process (GO:0030148) 106 14 .43 + 32.75 6.86E-14 lipid metabolic process (GO:0006629) 1211 31 4.88 + 6.35 1.40E-13 amide biosynthetic process (GO:0043604) 155 15 .63 + 24.00 5.12E-13 dolichol metabolic process (GO:0019348) 8 7 .03 + > 100 9.78E-13 UDP-N-acetylglucosamine metabolic process (GO:0006047) 14 8 .06 + > 100 1.33E-12 macromolecule metabolic process (GO:0043170) 5404 57 21.79 + 2.62 6.47E-12 UDP-N-acetylglucosamine biosynthetic process (GO:0006048) 10 7 .04 + > 100 1.46E-11 polyprenol metabolic process (GO:0016093) 10 7 .04 + > 100 1.46E-11 GDP-mannose biosynthetic process (GO:0009298) 6 6 .02 + > 100 3.28E-11 GDP-L-fucose biosynthetic process (GO:0042350) 6 6 .02 + > 100 3.28E-11 GDP-L-fucose metabolic process (GO:0046368) 7 6 .03 + > 100 2.29E-10 oligosaccharide biosynthetic process (GO:0009312) 27 8 .11 + 73.47 9.45E-10 protein O-linked glycosylation (GO:0006493) 100 11 .40 + 27.27 2.24E-09 viral protein processing (GO:0019082) 31 8 .13 + 63.99 3.32E-09 dolichyl diphosphate biosynthetic process (GO:0006489) 5 5 .02 + > 100 8.64E-09 CMP-N-acetylneuraminate biosynthetic process (GO:0006055) 5 5 .02 + > 100 8.64E-09 dolichyl diphosphate metabolic process (GO:0046465) 5 5 .02 + > 100 8.64E-09 CMP-N-acetylneuraminate metabolic process (GO:0046381) 6 5 .02 + > 100 5.17E-08 carbohydrate biosynthetic process (GO:0016051) 116 10 .47 + 21.38 3.44E-07 ganglioside catabolic process (GO:0006689) 8 5 .03 + > 100 4.79E-07 keratan sulfate proteoglycan metabolic process (GO:0042339) 18 6 .07 + 82.65 5.85E-07 O-glycan processing (GO:0016266) 39 7 .16 + 44.50 1.70E-06 mannose metabolic process (GO:0006013) 10 5 .04 + > 100 2.14E-06 dolichol phosphate mannose biosynthetic process (GO:0180047) 4 4 .02 + > 100 2.25E-06 protein sialylation (GO:1990743) 4 4 .02 + > 100 2.25E-06 N-glycan processing (GO:0006491) 22 6 .09 + 67.62 2.32E-06 cellular component organization or biogenesis (GO:0071840) 5931 2 23.92 - .08 4.23E-06 viral gene expression (GO:0019080) 74 8 .30 + 26.81 5.51E-06 glucosamine-containing compound metabolic process (GO:1901071) 26 6 .10 + 57.22 7.07E-06 cellular component organization (GO:0016043) 5717 2 23.06 - .09 1.42E-05 cellular process (GO:0009987) 15563 82 62.77 + 1.31 3.25E-05 N-acetylneuraminate catabolic process (GO:0019262) 6 4 .02 + > 100 3.36E-05 keratan sulfate proteoglycan biosynthetic process (GO:0018146) 16 5 .06 + 77.48 3.65E-05 glycosphingolipid catabolic process (GO:0046479) 18 5 .07 + 68.88 7.11E-05 N-acetylglucosamine metabolic process (GO:0006044) 19 5 .08 + 65.25 9.61E-05 carbohydrate derivative catabolic process (GO:1901136) 207 10 .83 + 11.98 1.00E-04 regulation of biological process (GO:0050789) 11815 22 47.65 - .46 1.62E-04 glycolipid catabolic process (GO:0019377) 21 5 .08 + 59.04 1.67E-04 ceramide catabolic process (GO:0046514) 21 5 .08 + 59.04 1.67E-04 regulation of cellular process (GO:0050794) 11417 21 46.05 - .46 2.41E-04 isoprenoid metabolic process (GO:0006720) 120 8 .48 + 16.53 2.65E-04 cellular response to stimulus (GO:0051716) 6478 5 26.13 - .19 3.01E-04 GDP-mannose biosynthetic process from mannose (GO:0061728) 3 3 .01 + > 100 5.79E-04 GDP-L-fucose salvage (GO:0042352) 3 3 .01 + > 100 5.79E-04 'de novo' GDP-L-fucose biosynthetic process (GO:0042351) 3 3 .01 + > 100 5.79E-04 N-acetylneuraminate biosynthetic process (GO:0046380) 3 3 .01 + > 100 5.79E-04 nucleobase-containing compound biosynthetic process (GO:0034654) 1793 24 7.23 + 3.32 8.38E-04 biological regulation (GO:0065007) 12219 25 49.28 - .51 1.03E-03 viral process (GO:0016032) 266 10 1.07 + 9.32 1.07E-03 fructose 6-phosphate metabolic process (GO:0006002) 14 4 .06 + 70.84 2.18E-03 amino sugar catabolic process (GO:0046348) 14 4 .06 + 70.84 2.18E-03 dolichol biosynthetic process (GO:0019408) 4 3 .02 + > 100 2.31E-03 polyprenol biosynthetic process (GO:0016094) 4 3 .02 + > 100 2.31E-03 phospholipid biosynthetic process (GO:0008654) 230 9 .93 + 9.70 3.41E-03 hexose metabolic process (GO:0019318) 168 8 .68 + 11.81 3.58E-03 oligosaccharide catabolic process (GO:0009313) 16 4 .06 + 61.99 3.95E-03 sphingolipid catabolic process (GO:0030149) 42 5 .17 + 29.52 6.54E-03 carbohydrate catabolic process (GO:0016052) 125 7 .50 + 13.89 6.67E-03 regulation of macromolecule metabolic process (GO:0060255) 5709 5 23.02 - .22 7.91E-03 cell communication (GO:0007154) 5328 4 21.49 - .19 8.07E-03 signaling (GO:0023052) 5282 4 21.30 - .19 8.25E-03 monosaccharide metabolic process (GO:0005996) 191 8 .77 + 10.39 9.47E-03 mannosylation (GO:0097502) 20 4 .08 + 49.59 1.04E-02 protein mannosylation (GO:0035268) 20 4 .08 + 49.59 1.04E-02 ganglioside biosynthetic process via lactosylceramide (GO:0010706) 6 3 .02 + > 100 1.15E-02 membrane lipid catabolic process (GO:0046466) 48 5 .19 + 25.83 1.29E-02 regulation of primary metabolic process (GO:0080090) 5174 4 20.87 - .19 1.36E-02 carbohydrate phosphorylation (GO:0046835) 24 4 .10 + 41.33 2.25E-02 regulation of macromolecule biosynthetic process (GO:0010556) 5014 4 20.22 - .20 3.64E-02 signal transduction (GO:0007165) 4942 4 19.93 - .20 3.68E-02 proteoglycan metabolic process (GO:0006029) 106 6 .43 + 14.04 4.05E-02 isoprenoid biosynthetic process (GO:0008299) 28 4 .11 + 35.42 4.28E-02 female mating behavior (GO:0060180) 9 3 .04 + 82.65 4.78E-02