Analysis Type: PANTHER Overrepresentation Test (Released 20240226) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.10536401 Released 2024-01-17 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20592) upload_1 (36) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) sucrose biosynthetic process (GO:0005986) 2 2 .00 + > 100 2.97E-06 4.08E-04 fructose 2,6-bisphosphate metabolic process (GO:0006003) 5 5 .01 + > 100 1.22E-14 2.48E-12 GDP-mannose biosynthetic process (GO:0009298) 5 5 .01 + > 100 1.22E-14 2.45E-12 'de novo' GDP-L-fucose biosynthetic process (GO:0042351) 2 2 .00 + > 100 2.97E-06 4.04E-04 GDP-L-fucose biosynthetic process (GO:0042350) 3 3 .01 + > 100 4.91E-09 7.48E-07 fructose 1,6-bisphosphate metabolic process (GO:0030388) 8 8 .01 + > 100 3.78E-23 1.92E-20 fructose biosynthetic process (GO:0046370) 2 2 .00 + > 100 2.97E-06 4.01E-04 fructose metabolic process (GO:0006000) 14 13 .02 + > 100 1.69E-36 6.43E-33 GDP-mannose metabolic process (GO:0019673) 9 7 .02 + > 100 9.63E-19 3.06E-16 fructose 6-phosphate metabolic process (GO:0006002) 12 9 .02 + > 100 1.13E-23 6.14E-21 GDP-L-fucose metabolic process (GO:0046368) 4 3 .01 + > 100 1.96E-08 2.96E-06 fructose catabolic process (GO:0006001) 3 2 .01 + > 100 8.91E-06 1.11E-03 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate (GO:0061624) 3 2 .01 + > 100 8.91E-06 1.10E-03 sucrose metabolic process (GO:0005985) 4 2 .01 + > 100 1.78E-05 2.15E-03 disaccharide biosynthetic process (GO:0046351) 4 2 .01 + > 100 1.78E-05 2.14E-03 carbohydrate phosphorylation (GO:0046835) 25 12 .04 + > 100 5.31E-28 5.78E-25 mannose metabolic process (GO:0006013) 9 4 .02 + > 100 9.85E-10 1.53E-07 cellular hyperosmotic salinity response (GO:0071475) 5 2 .01 + > 100 2.96E-05 3.34E-03 nucleotide-sugar biosynthetic process (GO:0009226) 20 8 .03 + > 100 4.69E-18 1.43E-15 maintenance of protein location in mitochondrion (GO:0072656) 5 2 .01 + > 100 2.96E-05 3.32E-03 NADH regeneration (GO:0006735) 18 7 .03 + > 100 8.42E-16 2.29E-13 glucose catabolic process to pyruvate (GO:0061718) 18 7 .03 + > 100 8.42E-16 2.25E-13 canonical glycolysis (GO:0061621) 18 7 .03 + > 100 8.42E-16 2.21E-13 alditol catabolic process (GO:0019405) 8 3 .01 + > 100 2.73E-07 3.97E-05 glucose catabolic process (GO:0006007) 25 9 .04 + > 100 1.03E-19 3.57E-17 glycolytic process through glucose-6-phosphate (GO:0061620) 20 7 .03 + > 100 2.05E-15 4.95E-13 glycolytic process through fructose-6-phosphate (GO:0061615) 20 7 .03 + > 100 2.05E-15 4.87E-13 NAD catabolic process (GO:0019677) 21 7 .04 + > 100 3.07E-15 6.98E-13 hyperosmotic salinity response (GO:0042538) 6 2 .01 + > 100 4.44E-05 4.80E-03 glycolytic process (GO:0006096) 47 14 .08 + > 100 4.46E-29 8.49E-26 ADP catabolic process (GO:0046032) 49 14 .09 + > 100 8.79E-29 1.49E-25 regulation of pentose-phosphate shunt (GO:0043456) 7 2 .01 + > 100 6.21E-05 6.62E-03 glycerol catabolic process (GO:0019563) 7 2 .01 + > 100 6.21E-05 6.57E-03 pyridine nucleotide catabolic process (GO:0019364) 51 14 .09 + > 100 1.68E-28 2.56E-25 polyol catabolic process (GO:0046174) 11 3 .02 + > 100 8.02E-07 1.13E-04 purine ribonucleoside diphosphate catabolic process (GO:0009181) 52 14 .09 + > 100 2.30E-28 3.18E-25 purine nucleoside diphosphate catabolic process (GO:0009137) 52 14 .09 + > 100 2.30E-28 2.92E-25 hexose catabolic process (GO:0019320) 42 11 .07 + > 100 3.52E-22 1.53E-19 pyridine-containing compound catabolic process (GO:0072526) 54 14 .09 + > 100 4.21E-28 4.93E-25 ribonucleoside diphosphate catabolic process (GO:0009191) 55 14 .10 + > 100 5.64E-28 5.73E-25 ADP metabolic process (GO:0046031) 56 14 .10 + > 100 7.51E-28 7.15E-25 NADH metabolic process (GO:0006734) 32 8 .06 + > 100 3.86E-16 1.09E-13 glyceraldehyde-3-phosphate metabolic process (GO:0019682) 12 3 .02 + > 100 1.07E-06 1.49E-04 monosaccharide catabolic process (GO:0046365) 46 11 .08 + > 100 1.09E-21 4.50E-19 nucleoside diphosphate catabolic process (GO:0009134) 59 14 .10 + > 100 1.71E-27 1.54E-24 daunorubicin metabolic process (GO:0044597) 9 2 .02 + > 100 1.06E-04 1.09E-02 nucleotide-sugar metabolic process (GO:0009225) 38 8 .07 + > 100 1.78E-15 4.38E-13 purine ribonucleoside diphosphate metabolic process (GO:0009179) 68 14 .12 + > 100 1.57E-26 1.26E-23 purine nucleoside diphosphate metabolic process (GO:0009135) 68 14 .12 + > 100 1.57E-26 1.20E-23 cellular response to salt stress (GO:0071472) 10 2 .02 + > 100 1.33E-04 1.35E-02 doxorubicin metabolic process (GO:0044598) 10 2 .02 + > 100 1.33E-04 1.34E-02 regulation of NADP metabolic process (GO:1902031) 10 2 .02 + > 100 1.33E-04 1.33E-02 aminoglycoside antibiotic metabolic process (GO:0030647) 10 2 .02 + > 100 1.33E-04 1.32E-02 polyketide metabolic process (GO:0030638) 10 2 .02 + > 100 1.33E-04 1.31E-02 pyruvate metabolic process (GO:0006090) 72 14 .13 + > 100 3.80E-26 2.76E-23 ribonucleoside diphosphate metabolic process (GO:0009185) 78 14 .14 + > 100 1.30E-25 8.97E-23 disaccharide metabolic process (GO:0005984) 12 2 .02 + 95.33 1.94E-04 1.90E-02 negative regulation of purine nucleotide catabolic process (GO:0033122) 18 3 .03 + 95.33 3.93E-06 5.17E-04 glucose 6-phosphate metabolic process (GO:0051156) 24 4 .04 + 95.33 8.15E-08 1.22E-05 negative regulation of nucleotide catabolic process (GO:0030812) 18 3 .03 + 95.33 3.93E-06 5.12E-04 negative regulation of glycolytic process (GO:0045820) 18 3 .03 + 95.33 3.93E-06 5.08E-04 nucleoside diphosphate metabolic process (GO:0009132) 85 14 .15 + 94.21 4.77E-25 3.03E-22 hexose metabolic process (GO:0019318) 162 26 .28 + 91.80 5.68E-48 8.66E-44 negative regulation of purine nucleotide metabolic process (GO:1900543) 25 4 .04 + 91.52 9.69E-08 1.43E-05 carbohydrate catabolic process (GO:0016052) 110 17 .19 + 88.40 5.09E-30 1.11E-26 negative regulation of nucleotide metabolic process (GO:0045980) 26 4 .05 + 88.00 1.14E-07 1.68E-05 purine ribonucleotide catabolic process (GO:0009154) 92 14 .16 + 87.04 1.57E-24 9.58E-22 hexose biosynthetic process (GO:0019319) 53 8 .09 + 86.34 3.17E-14 6.12E-12 ribonucleotide catabolic process (GO:0009261) 99 14 .17 + 80.89 4.71E-24 2.76E-21 monosaccharide metabolic process (GO:0005996) 184 26 .32 + 80.83 2.01E-46 1.53E-42 monosaccharide biosynthetic process (GO:0046364) 57 8 .10 + 80.28 5.89E-14 1.09E-11 purine nucleotide catabolic process (GO:0006195) 101 14 .18 + 79.29 6.34E-24 3.58E-21 negative regulation of ATP metabolic process (GO:1903579) 22 3 .04 + 78.00 7.39E-06 9.30E-04 tertiary alcohol metabolic process (GO:1902644) 15 2 .03 + 76.27 3.08E-04 2.89E-02 glucose metabolic process (GO:0006006) 121 16 .21 + 75.64 4.78E-27 4.05E-24 purine-containing compound catabolic process (GO:0072523) 107 14 .19 + 74.84 1.49E-23 7.86E-21 NAD metabolic process (GO:0019674) 62 8 .11 + 73.81 1.20E-13 2.20E-11 alditol metabolic process (GO:0019400) 24 3 .04 + 71.50 9.68E-06 1.19E-03 cellular hyperosmotic response (GO:0071474) 16 2 .03 + 71.50 3.51E-04 3.28E-02 gluconeogenesis (GO:0006094) 50 6 .09 + 68.64 2.77E-10 4.40E-08 pyridine nucleotide metabolic process (GO:0019362) 119 14 .21 + 67.29 7.18E-23 3.53E-20 nicotinamide nucleotide metabolic process (GO:0046496) 119 14 .21 + 67.29 7.18E-23 3.42E-20 nucleotide catabolic process (GO:0009166) 125 14 .22 + 64.06 1.48E-22 6.83E-20 alcohol catabolic process (GO:0046164) 36 4 .06 + 63.56 4.45E-07 6.40E-05 pyridine-containing compound metabolic process (GO:0072524) 126 14 .22 + 63.56 1.66E-22 7.45E-20 lactate metabolic process (GO:0006089) 19 2 .03 + 60.21 4.99E-04 4.61E-02 nucleoside phosphate catabolic process (GO:1901292) 134 14 .23 + 59.76 4.09E-22 1.73E-19 ATP metabolic process (GO:0046034) 162 14 .28 + 49.43 6.42E-21 2.51E-18 purine ribonucleoside triphosphate metabolic process (GO:0009205) 186 14 .33 + 43.05 4.68E-20 1.78E-17 organophosphate catabolic process (GO:0046434) 186 14 .33 + 43.05 4.68E-20 1.74E-17 ribonucleoside triphosphate metabolic process (GO:0009199) 193 14 .34 + 41.49 7.94E-20 2.88E-17 purine nucleoside triphosphate metabolic process (GO:0009144) 193 14 .34 + 41.49 7.94E-20 2.81E-17 organic hydroxy compound catabolic process (GO:1901616) 59 4 .10 + 38.78 3.34E-06 4.47E-04 nucleoside triphosphate metabolic process (GO:0009141) 209 14 .37 + 38.32 2.47E-19 8.38E-17 regulation of carbohydrate catabolic process (GO:0043470) 60 4 .10 + 38.13 3.58E-06 4.74E-04 carbohydrate metabolic process (GO:0005975) 446 29 .78 + 37.19 1.58E-42 8.04E-39 carbohydrate derivative catabolic process (GO:1901136) 224 14 .39 + 35.75 6.63E-19 2.15E-16 carbohydrate biosynthetic process (GO:0016051) 130 8 .23 + 35.20 5.29E-11 8.68E-09 regulation of purine nucleotide catabolic process (GO:0033121) 51 3 .09 + 33.65 9.65E-05 1.01E-02 regulation of glycolytic process (GO:0006110) 51 3 .09 + 33.65 9.65E-05 1.00E-02 regulation of nucleotide catabolic process (GO:0030811) 51 3 .09 + 33.65 9.65E-05 9.93E-03 negative regulation of carbohydrate metabolic process (GO:0045912) 62 3 .11 + 27.68 1.73E-04 1.70E-02 regulation of purine nucleotide metabolic process (GO:1900542) 90 4 .16 + 25.42 1.81E-05 2.15E-03 regulation of nucleotide metabolic process (GO:0006140) 91 4 .16 + 25.14 1.89E-05 2.23E-03 cellular aldehyde metabolic process (GO:0006081) 69 3 .12 + 24.87 2.38E-04 2.29E-02 nucleobase-containing compound catabolic process (GO:0034655) 336 14 .59 + 23.83 1.99E-16 5.72E-14 regulation of ATP metabolic process (GO:1903578) 72 3 .13 + 23.83 2.69E-04 2.55E-02 small molecule catabolic process (GO:0044282) 354 14 .62 + 22.62 4.11E-16 1.14E-13 generation of precursor metabolites and energy (GO:0006091) 412 16 .72 + 22.21 2.50E-18 7.79E-16 intracellular glucose homeostasis (GO:0001678) 106 4 .19 + 21.58 3.44E-05 3.80E-03 cellular nitrogen compound catabolic process (GO:0044270) 378 14 .66 + 21.19 1.02E-15 2.64E-13 heterocycle catabolic process (GO:0046700) 379 14 .66 + 21.13 1.06E-15 2.69E-13 negative regulation of small molecule metabolic process (GO:0062014) 109 4 .19 + 20.99 3.84E-05 4.21E-03 purine ribonucleotide metabolic process (GO:0009150) 384 14 .67 + 20.85 1.27E-15 3.18E-13 regulation of generation of precursor metabolites and energy (GO:0043467) 138 5 .24 + 20.72 4.01E-06 5.14E-04 nucleobase-containing small molecule metabolic process (GO:0055086) 608 22 1.06 + 20.70 3.92E-25 2.60E-22 aromatic compound catabolic process (GO:0019439) 399 14 .70 + 20.07 2.16E-15 5.07E-13 ribonucleotide metabolic process (GO:0009259) 406 14 .71 + 19.72 2.75E-15 6.35E-13 cellular ketone metabolic process (GO:0042180) 88 3 .15 + 19.50 4.86E-04 4.52E-02 ribose phosphate metabolic process (GO:0019693) 420 14 .73 + 19.07 4.39E-15 9.56E-13 organic cyclic compound catabolic process (GO:1901361) 427 14 .75 + 18.75 5.51E-15 1.17E-12 monocarboxylic acid metabolic process (GO:0032787) 528 16 .92 + 17.33 1.27E-16 3.72E-14 purine nucleotide metabolic process (GO:0006163) 466 14 .81 + 17.18 1.83E-14 3.63E-12 carbohydrate derivative metabolic process (GO:1901135) 1005 30 1.76 + 17.07 4.37E-34 1.33E-30 nucleotide metabolic process (GO:0009117) 529 15 .92 + 16.22 3.90E-15 8.62E-13 purine-containing compound metabolic process (GO:0072521) 498 14 .87 + 16.08 4.56E-14 8.58E-12 nucleoside phosphate metabolic process (GO:0006753) 537 15 .94 + 15.98 4.86E-15 1.04E-12 regulation of carbohydrate metabolic process (GO:0006109) 185 5 .32 + 15.46 1.67E-05 2.03E-03 glucose homeostasis (GO:0042593) 206 5 .36 + 13.88 2.80E-05 3.20E-03 carbohydrate homeostasis (GO:0033500) 207 5 .36 + 13.82 2.86E-05 3.25E-03 organophosphate metabolic process (GO:0019637) 942 22 1.65 + 13.36 5.48E-21 2.20E-18 response to carbohydrate (GO:0009743) 175 4 .31 + 13.07 2.40E-04 2.30E-02 carboxylic acid metabolic process (GO:0019752) 801 17 1.40 + 12.14 3.89E-15 8.71E-13 oxoacid metabolic process (GO:0043436) 823 17 1.44 + 11.82 6.07E-15 1.27E-12 organic acid metabolic process (GO:0006082) 830 17 1.45 + 11.72 6.97E-15 1.44E-12 small molecule metabolic process (GO:0044281) 1640 33 2.87 + 11.51 2.29E-33 5.81E-30 phosphorylation (GO:0016310) 745 14 1.30 + 10.75 1.06E-11 1.81E-09 carbohydrate derivative biosynthetic process (GO:1901137) 607 11 1.06 + 10.37 4.10E-09 6.32E-07 small molecule biosynthetic process (GO:0044283) 469 8 .82 + 9.76 1.18E-06 1.63E-04 alcohol metabolic process (GO:0006066) 331 5 .58 + 8.64 2.61E-04 2.48E-02 cellular catabolic process (GO:0044248) 1132 17 1.98 + 8.59 1.08E-12 1.94E-10 phosphorus metabolic process (GO:0006793) 1737 25 3.04 + 8.23 2.91E-19 9.64E-17 organic hydroxy compound metabolic process (GO:1901615) 494 7 .86 + 8.11 2.00E-05 2.33E-03 phosphate-containing compound metabolic process (GO:0006796) 1711 23 2.99 + 7.69 9.82E-17 2.94E-14 organonitrogen compound catabolic process (GO:1901565) 1126 15 1.97 + 7.62 2.00E-10 3.22E-08 organic substance catabolic process (GO:1901575) 1635 18 2.86 + 6.30 3.26E-11 5.40E-09 heterocycle biosynthetic process (GO:0018130) 1014 10 1.77 + 5.64 6.31E-06 8.02E-04 nucleobase-containing compound biosynthetic process (GO:0034654) 938 9 1.64 + 5.49 2.52E-05 2.91E-03 catabolic process (GO:0009056) 1938 18 3.39 + 5.31 5.38E-10 8.45E-08 aromatic compound biosynthetic process (GO:0019438) 1024 9 1.79 + 5.03 5.01E-05 5.37E-03 organic cyclic compound biosynthetic process (GO:1901362) 1150 10 2.01 + 4.97 1.90E-05 2.23E-03 cellular aromatic compound metabolic process (GO:0006725) 2971 24 5.19 + 4.62 1.30E-12 2.30E-10 nucleobase-containing compound metabolic process (GO:0006139) 2743 22 4.80 + 4.59 2.92E-11 4.90E-09 heterocycle metabolic process (GO:0046483) 2931 23 5.12 + 4.49 1.09E-11 1.84E-09 organic cyclic compound metabolic process (GO:1901360) 3226 24 5.64 + 4.26 8.00E-12 1.39E-09 cellular nitrogen compound metabolic process (GO:0034641) 3288 23 5.75 + 4.00 1.20E-10 1.95E-08 cellular nitrogen compound biosynthetic process (GO:0044271) 1539 10 2.69 + 3.72 2.22E-04 2.15E-02 cellular metabolic process (GO:0044237) 6416 33 11.22 + 2.94 4.46E-14 8.50E-12 primary metabolic process (GO:0044238) 6944 34 12.14 + 2.80 2.41E-14 4.71E-12 organic substance metabolic process (GO:0071704) 7437 34 13.00 + 2.62 2.32E-13 4.22E-11 organic substance biosynthetic process (GO:1901576) 3964 18 6.93 + 2.60 3.21E-05 3.57E-03 biosynthetic process (GO:0009058) 4016 18 7.02 + 2.56 3.85E-05 4.19E-03 metabolic process (GO:0008152) 7979 34 13.95 + 2.44 2.36E-12 4.13E-10 organonitrogen compound metabolic process (GO:1901564) 4671 19 8.17 + 2.33 8.07E-05 8.48E-03 nitrogen compound metabolic process (GO:0006807) 6426 26 11.23 + 2.31 4.99E-07 7.11E-05