>NPY1R_HUMAN/57-320 GNLALIIIILK-Q--KE--MR---N-V--TNILIVNLSFSDLLVAIMCLPFTFV-Y-------T-L-M---- -DHWVF--GEA---MCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR---PNNR--HAYVGIAVIWV LAVAS-SLPF-LIYQVM---TDE-PF---QNVTLDAYK---------D--KYVCFDQFPS--D--------S HR-LSYTTLLLVLQ--Y-FGPLC-------FIFICYFKIYIRLKRRNNM----------------------- ---MD------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------K-M--R----------------- -----------------------------------DNKYRSSE--TKRINIMLLSIVVAFAVCWLPLTIFNT VFDWNH--QIIA--TCNH-------NLL-FLLCHLTAMISTCVNPIFY >TLR1_DROME/100-363 GNGIVLWIVTG-H--RS--MR---T-V--TNYFLLNLSIADLLMSSLNCVFNFI-F-------M-L-N---- -SDWPF--GSI---YCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTS---RR--KVRIILVLIWA LSCVL-SAPC-LLYSSI---MTK-HY---Y-----NGK---------S--RTVCFMMWPD--GRY---PTSM AD-YAYNLIILVLT--Y-GIPMI-------VMLICYSLMGRVLWGSRSI----------------------- ---GE------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------N-T--D----------------- -----------------------------------RQMESMKS--KRKVVRMFIAIVSIFAICWLPYHLFFI YAYHNN-Q-------VASTKY---VQHM-YLGFYWLAMSNAMVNPLIY >NK1R_CAVPO/49-305 GNVVVMWIILA-H--KR--MR---T-V--TNYFLVNLAFAEASMAAFNTVVNFT-Y-------A-V-H---- -NEWYY--GLF---YCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLS---AT--ATKVVICVIWV LALLL-AFPQ-GYYSTT---ETM--------------P---------G--RVVCMIEWPS--H-----PDKI YE-KVYHICVTVLI--Y-FLPLL-------VIGYAYTVVGITLWASEIP----------------------- ---GD------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------S-S--D----------------- -----------------------------------RYHEQVSA--KRKVVKMMIVVVCTFAICWLPFHIFFL LPYINP-D-------LYLKKF---IQQV-YLAIMWLAMSSTMYNPIIY >RYAR_DROME/122-383 GNGTVCYIVYS-T--PR--MR---T-V--TNYFIASLAIGDILMSFFCVPSSFISL-------F-I-L---- -NYWPF--GLA---LCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRIT---KR--YATFIIAGVWF IALAT-ALPI-PIVSGL---DIP-MS-PWH-----TKC---------E--KYICREMWPS----------RT QE-YYYTLSLFALQ--F-VVPLG-------VLIFTYARITIRVWAKRPP----------------------- ---GE------A------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------E-T--N----------------- -----------------------------------RDQRMARS--KRKMVKMMLTVVIVFTCCWLPFNILQL LLNDEE-F--------AHWDP---LPYV-WFAFHWLAMSHCCYNPIIY >GPR83_MOUSE/88-345 GNVLVCHVIFK-N--QR--MH---S-A--TSLFIVNLAVADIMITLLNTPFTLVR--------F-V-N---- -STWVF--GKG---MCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRIS---IT--KGVIYIAVIWV MATFF-SLPH-AICQKLFTFKYS------------EDI---------V--RSLCLPDFPE--------PADL FW-KYLDLATFILL--Y-LLPLF-------IISVAYARVAKKLWLCNTI----------------------- ---GD------V------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------T-T--E----------------- -----------------------------------QYLALRRK--KKTTVKMLVLVVVLFALCWFPLNCYVL LLSSKA------------IHT---NNAL-YFAFHWFAMSSTCYNPFIY >CCKAR_HUMAN/58-370 GNTLVITVLIR-N--KR--MR---T-V--TNIFLLSLAVSDLMLCLFCMPFNLI-P--------NL-L---- -KDFIF--GSA---VCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVW-QTKS--HALKVIAATWC LSFTI-MTPY-PIYSNL---VPFTKN---------NNQ---------T--ANMCRFLLPN----------DV MQ-QSWHTFLLLIL--F-LIPGI-------VMMVAYGLISLELYQGIKFE---------------------- ---ASQKKSAKERKPSTTSSGKYEDS------------------DG---------------------C---- ------------------------------------------------------------------------ --------------------YLQ------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------KTR PPRKLELRQLS--------TG---------------------------SS-SRANRIR-------------- ---------------------------------SNSSAANLMA--KKRVIRMLIVIVVLFFLCWMPIFSANA WRAYDT-AS-------AERRL---SGTP-ISFILLLSYTSSCVNPIIY >BRS3_CAVPO/64-330 GNAILIKVFFK-T--KS--MQ---T-V--PNIFITSLALGDLLLLLTCVPVDAT-H-------Y-L-A---- -EGWLF--GR---IGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPS-NAIL--KTCAKAGCIWI MSMIF-ALPE-AIFSNV---HTL-R----D-----PNK-------NMT--SEWCAFYP---------VSEKL LQ-EIHALLSFLVF--Y-IIPL-------SIISVYYSLIARTLY----KS---------------------- -----------------------TLN-I----------P-T------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------EE-Q-------------------- ----------------------------------SHARKQVES--RKRIAKTVLVLVALFALCWLPNHLLNL YHSFTH-KA------YEDSSA---IHFIVTIFSRVLAFSNSCVNPFAL >OPSB_PANTR/51-303 LNAMVLVATLR-Y--KK--LR---Q-P--LNYILVNVSFGGFLLCIFSVFPVFVAS---------C-N---- -GYFVF--GRH---VCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRF--SSK--HALTVVLATWT IGIGV-SIPP-FFGWSR---FIP------------E-G---------L--QCSCGPDWYT--V-----GTKY RS-ESYTWFLFIFC--F-IVPLS-------LICFSYTQLLRALKAVAAQ----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------Q--Q----------------- -----------------------------------ESATTQKA--EREVSRMVVVMVGSFCVCYVPYAAFAM YMVNNR-----------NHGL---DLRL-VTIPSFFSKSACIYNPIIY >OPS1_DROME/67-329 GNGVVIYIFAT-T--KS--LR---T-P--ANLLVINLAISDFGIMITNTPMMGI-N--------LY-F---- -ETWVL--GPM---MCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPM--TIP--LALGKIAYIWF MSSIW-CLAP-AFGWSR---YVP--E---------GN-------------LTSCGIDYLE---------RDW NP-RSYLIFYSIFV--Y-YIPLF-------LICYSYWFIIAAVSAHEKAM---------------------- ---R-------EQAK--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KMNVK-----------------------------------------------SLR-------------- ---------------------------------SSE-DAEKSA--EGKLAKVALVTITLWFMAWTPYLVINC MGLFKF-----------EG-L---TPLN-TIWGACFAKSAACYNPIVY >OPS3_DROME/75-338 GNGLVIWVFSA-A--KS--LR---T-P--SNILVINLAFCDFMMMV-KTPIFIY-N--------SF-H---- -QGYAL--GHL---GCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEGKMT---HG--KAIAMIIFIYM YATPW-VVACYTETWGR---FVP--E---------GY-------------LTSCTFDYLT---------DNF DT-RLFVACIFFFS--F-VCPTT-------MITYYYSQIVGHVFSHEKAL---------------------- ---R-------DQAK--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KMNVE-----------------------------------------------SLR-------------- ---------------------------------SNVDKNKETA--EIRIAKAAITICFLFFCSWTPYGVMSL IGAFGD-----------KTLL---TPGA-TMIPACACKMVACIDPFVY >FSHR_BOVIN/379-626 GNILVLVILIT-S--QY--KL---T-V--PRFLMCNLAFADLCIGIYLLLIASVDVHTKTEYHN-Y-A---- -IDWQT--G-A---GCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECK-VQLR--HAASIMLVGWI FAFAV-ALFP-IFGIS----SYM------------K--------------VSICLPMDID----------SP LS-QLY-VMSLLVL--N-VLAFV-------VICGCYTHIYLTVRNPN------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------ITSSSS--DTKIAKRMAMLIFTDFLCMAPISFFAI SASLKV-P----------LIT---VSKS-KILLVLFYPINSCANPFLY >O10J1_HUMAN/52-300 GNIIIVTIIRM-D--LH--LH---T-P--MYFFLSMLSTSETVYTLVILPRMLS-S-------L-V-G---- -MSQPI--SL---AGCATQMFFFVTFGITNCFLLTAMGYDRYVAICNPLRYMVI-MNKR--LRIQLVLGACS IGLIV-AITQ-VTSVFR---LPF-C----------A-R-------KVP--HFFCDIRPVMKLS----CIDTT VN-EILTLIISVLV--L-VVPM-------GLVFISYVLIISTIL----KI---------------------- --------------------------------------A--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------SVEG--RKKAFATCASHLTVVIVHYSCAS-IAY LKPK-----------SENT-----REH-DQLISVTYTVITPLLNPVVY >OL867_RAT/22-271 GNLLIILAVSS-N--SH--LH---N-L--MYFFLSNLSFVDICFISTTIPKMLV-N-------I-H-S---- -QTKDI--SY---IECLSQVYFLTTFGGMDNFLLTLMACDRYVAICHPLNYTVI-MNLQ--LCALLILMFWL IMFCV-SLIH-VLLMNE---LNF-S----------RGT-------EIP--HFFCELAQVLKVA----NSDTH IN-NVFMYVVTSLL--G-LIPM-------TGILMSYSQIASSLL----KM---------------------- --------------------------------------S--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------SSVS--KYKAFSTCGSHLCVVSLFYGSAT-IVY FCSS-----------VLHS-----THK-KMIASLMYTVISPMLNPFIY >OL287_RAT/44-293 GNLAIISLVGA-H--RC--LQ---T-P--MYFFLCNLSFLEIWFTTACVPKTLA-T-------F-A-P---- -RGGVI--SL---AGCATQMYFVFSLGCTEYFLLAVMAYDRYLAICLPLRYGGI-MTPG--LAMRLALGSWL CGFSAITVPA-T-LIAR---LSF-C----------GSR-------VIN--HFFCDISPWIVLS----CTD-- ------TQVVELVS--F-GIAFCVILGSCGITLVSYAYIITTII----KI---------------------- --------------------------------------P--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------SARG--RHRAFSTCSSHLTVVLIWYGSTI-FLH VRTS-----------VESS-----LDL-TKAITVLNTIVTPVLNPFIY >OLF1_CHICK/41-290 TNLGLIALISV-D--LH--LQ---T-P--MYIFLQNLSFTDAAYSTVITPKMLA-T-------F-L-E---- -ERKTI--SY---VGCILQYFSFVLLTVTESLLLAVMAYDRYVAICKPLLYPSI-MTKA--VCWRLVESLYF LAFLN-SLVH-TSGLLK---LSF-C----------YSN-------VVN--HFFCDISPLFQIS----SSSIA IS-ELLVIISGSLF--V-MSSI-------IIILISYVFIILTVV----MI---------------------- --------------------------------------R--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------SKDG--KYKAFSTCTSHLMAVSLFHGTVI-FMY LRPV-----------KLFS-----LDT-DKIASLFYTVVIPMLNPLIY >OR2C1_MOUSE/41-290 GNLTIILLSRL-D--AR--LH---T-P--MYFFLSNLSSLDLAFTTSSVPQMLK-N-------L-W-G---- -PDKTI--SY---GGCVTQLYVFLWLGATECILLVVMAFDRYVAVCRPLHYMTV-MNPR--LCWGLAAISWL GGLGN-SVIQ-STFTLQ---LPF-C----------GHR-------KVD--NFLCEVPAMIKLA----CGDTS LN-E--AVLNGVCTFFT-VVPV-------SVILVSYCFIAQAVM----KI---------------------- --------------------------------------R--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------SVEG--RRKAFNTCVSHLVVVFLFYGSAI-YGY LLPA-----------KSSN-----QSQ-GKFISLFYSVVTPMVNPLIY >TA2R_HUMAN/41-308 SNLLALSVLAG-A--RQ--GGSH-T-RSSFLTFLCGLVLTDFLGLLVTGTIVVSQH-------A-A-L---- -FEWHA--VDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAV-ASQR--RAWATVGLVWA AALAL-GLLP-LLGVGR---YTV-Q----------Y-----------P--GSWCFLTLGA---------E-S GD-VAFGLLFSMLG-GL-SVGLSFLLNTVSVATLCHVYH--GQEA--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------AQQRPRDS--EVEMMAQLLGIMVVASVCWLPLLVFIA QTVLRN-PPAM-SPAGQLSRT---TEK-ELLIYLRVATWNQILDPWVY >PE2R4_HUMAN/34-329 GNLVAIVVLCK-S--RK--EQ---K-ETTFYTLVCGLAVTDLLGTLLVSPVTIA-T-------Y-M-K---- -GQWPG--GQ---PLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHY-VDKR--LAGLTLFAVYA SNVLF-CALP-NMGLGS---SRL-Q----------Y-----------P--DTWCFIDWTT---------NVT AH-AAYSYMYAGFS-SF-LILA----TVLCNVLVCGALL-RMHRQFM-RRT--------------------- -----------------------SLGTE-QH--HAAAAA-SVASRGH------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---P-------------A------------------AS---PALPRLSDFRR-------------------- ---------------------------------RRSFRRIAGA--EIQMVILLIATSLVVLICSIPLVVRVF VNQLYQ-PS------LERE-V---SKN-PDLQAIRIASVNPILDPWIY >5HT6R_RAT/43-320 ANSLLIVLICT-Q--PA--LR---N-T--SNFFLVSLFTSDLMVGLVVMPPAML-N-------A-L-Y---- -GRWVL--AR---GLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLR-MTAP--RALALILGAWS LAALA-SFLPLLLGWHE---LGK-AR----------TP---------A--PGQCRLL--------------- AS-LPFVLVASGVT--F-FLPSG-------AICFTYCRILLAARKQAVQ----------------------- ---VA------S------LT-T--------G-TAGQ-----------A--LET------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------LQVPR --TPR-----------PG----------------M-ES---A-------D-S--R--RL------------- ------------------------------------ATKHSRK--ALKASLTLGILLGMFFVTWLPFFVANI AQAVCD-------------CI---SPGL-FDVLTWLGYCNSTMNPIIY >ADRB1_HUMAN/75-377 GNVLVIVAIAK-T--PR--LQ---T-L--TNLFIMSLASADLVMGLLVVPFGAT-I-------V-V-W---- -GRWEY--GS---FFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSL-LTRA--RARGLVCTVWA ISALV-SFLPILMHWWR---AES-D-----------EA-------------RRCYNDPK--------CCDFV TN-RAYAIASSVVS--F-YVPLC-------IMAFVYLRVFREAQKQVKK----------------------- ---ID------S------CE-R--------RFL-GG-----------P--ARP------------------- ---------------------------------------------------------------PSPS----- ----------------------------------------------------PS------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------P--------------------- ----------------------------------------VPA----------------P-------APPPG --PPRPA--AA-AATAPLANG---------------RA-----------G-K--R--RP------------- ------------------------------------SRLVALR--EQKALKTLGIIMGVFTLCWLPFFLANV VKAFHR-E-----------LV---PDRL-FVFFNWLGYANSAFNPIIY >DRD1_HUMAN/40-331 GNTLVCAAVIR-F--RH--LR---SKV--TNFFVISLAVSDLLVAVLVMPWKAV-A-------E-I-A---- -GFWPF--GS----FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERK-MTPK--AAFILISVAWT LSVLI-SFIPVQLSWHK---AKP-TS---P-----SDG---------N--ATSLAETID--------NCDSS LS-RTYAISSSVIS--F-YIPVA-------IMIVTYTRIYRIAQKQIRR----------------------- ---IA------A------LE-R--------AAVHAK-----------N--CQT------------------- ---------------------------------------------------------------TT------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------GNG---------------KPVECS-------Q-P--E--SS------------- ------------------------------------FKMSFKR--ETKVLKTLSVIMGVFVCCWLPFFILNC ILPFCG-SGET-QPF----CI---DSNT-FDVFVWFGWANSSLNPIIY >HRH2_CANLF/35-288 GNVVVCLAVGL-N--RR--LR---S-L--TNCFIVSLAITDLLLGLLVLPFSAF-Y-------Q-L-S---- -CRWSF--GK---VFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVL-ITPV--RVAVSLVLIWV ISITL-SFLS-IHLGWN---SRN-ET---S------SF---------NHTIPKCKV---------------Q VN-LVYGLVDGLVT--F-YLPLL-------VMCITYYRIFKIARDQAKR-IHH------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------MGSWKAATIG--EHKATVTLAAVMGAFIICWFPYFTVFV YRGLKG-D------D----AI---NEAF-EAVVLWLGYANSALNPILY >5HT7R_HUMAN/98-384 GNCLVVISVCF-V--KK--LR---Q-P--SNYLIVSLALADLSVAVAVMPFVSV-T-------DLI-G---- -GKWIF--GH---FFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVR-QNGK--CMAKMILSVWL LSASI-TLPP-LFGW-A---QNV-ND------------------------DKVCLIS--------------- QD-FGYTIYSTAVA--F-YIPMS-------VMLFMYYQIYKAARKSAAK----------------------- ---HK------F------------------------------------------------------------ -----------------------------------------------------------PGF---PR----- ----------------------------------------------------VEP----------------- ---------DSVIALN-------------------------------------------------------- ------------------------------------------------------------------------ ---GIVKLQKE--------------VE---------ECANLSRLL--------------------------- ------------------------------------------------------------------------ -----------------------------------------K-------H-E--R--K-------------- ------------------------------------NISIFKR--EQKAATTLGIIVGAFTVCWLPFFLLST ARPFICGTSCS--------CI---PLWV-ERTFLWLGYANSLINPFIY >5HT1R_DROME/179-507 GNVLVCIAVCM-V--RK--LR---R-P--CNYLLVSLALSDLCVALLVMPMALL-Y-------E-V-L---- -EKWNF--GP---LLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVK-RTPR--RMMLCVGIVWL AAACI-SLPP-LLILGN---EHE-DE---E------G-------------QPICTVC--------------- QN-FAYQIYATLGS--F-YIPLS-------VMLFVYYQIFRAARRIVLE----------------------- ---EK------R------AQ-T--------HLQ--Q--------------ALN-------G----TGS---- -----------------------------------------------------------PSA---PQ----- ----------------------------------------------------APP----------------- ---------------L-------------------------------------------------------- ------------------------------------------------------------------------ ---GHTE-------------------------------------LASSGNGQRHSSVGNTSLTYSTCGGLSS GGGALAGHGS-------------------------------------------------------------- ---------GGGV----------------SGSTGLLGS---P-------H-H--K--K-------------- ------------------------------------LRFQLAK--EKKASTTLGIIMSAFTVCWLPFFILAL IRPFET---MH---------V---PASL-SSLFLWLGYANSLLNPIIY >5HT5A_MOUSE/57-338 WNLLVLATILK-V--RT--FH---R-V--PHNLVASMAISDVLVAVLVMPLSLV-H-------E-L-SG--- -RRWQL--GR---RLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLR-TRKR--VSNVMILLTWA LSTVI-SLAP-LLFGWG---ETY-S----E------P-------------SEECQVS--------------- RE-PSYTVFSTVGA--F-YLPLC-------VVLFVYWKIYRAAKFRMGS----------------------- ---RK------T------NS----------------------------------------V----SPV---- -----------------------------------------------------------P------------ -----------------------------------------------------EA----------------- -----------V------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------E------VK----------NA-----------------T Q-HPQMVFTVRHA--------------------TV-TF---Q-------T-E--G----------------- ------------------------------------DTWREQK--EQRAALMVGILIGVFVLCWFPFFVTEL ISPLCS-WD-----------V---PAIW-KSIFLWLGYSNSFFNPLIY >5HT1A_HUMAN/53-400 GNACVVAAIAL-E--RS--LQ---N-V--ANYLIGSLAVTDLMVSVLVLPMAAL-Y-------Q-V-L---- -NKWTL--GQ---VTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNK-RTPR--RAAALISLTWL IGFLI-SIPP-MLGWRT---PED-R----S------D-------------PDACTIS--------------- KD-HGYTIYSTFGA--F-YIPLL-------LMLVLYGRIFRAARFRIRK----------------------- ---TV------K------KVEK--------TGA--D--------------TRHG------A----SPA---- -----------------------------------------------------------P------------ -----------------------------------------------------QP----------------- --------KKSV---NG------------------------------------------------------- ------------------------------------------------------------------ESGSRN WRLGVE---------------------------------------------------------------S-K AGGALCANGAVRQGDDGAALEVIEVHRVGNSKEH------LP----------LP--S-E------------A G--PTPC--APAS----------------FERKNE-RN---A-------E-A--K----------------- ------------------------------------RKMALAR--ERKTVKTLGIIMGTFILCWLPFFIVAL VLPFCE-SS-C--------HM---PTLL-GAIINWLGYSNSLLNPVIY >5HT1B_HUMAN/66-369 SNAFVIATVYR-T--RK--LH---T-P--ANYLIASLAVTDLLVSILVMPISTM-Y-------T-V-T---- -GRWTL--GQ---VVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAK-RTPK--RAAVMIALVWV FSISI-SLPP-FFWRQA----KA-E----E------E-------------VSECVVN--------------- TDHILYTVYSTVGA--F-YFPTL-------LLIALYGRIYVEARSRILK----------------------- ---QT------P------NR----------TGK--R-----------LTRAQL-------I----TDS---- -----------------------------------------------------------P------------ -----------------------------------------------------GS----------------- --------TSSV------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------TSINSR------VPD---------VP--S-E------------S G-SPVYV---NQV----------------KVR-VS-DA---L-------L-E--K----------------- ------------------------------------KKLMAAR--ERKATKTLGIILGAFIVCWLPFFIISL VMPICK-DA-C--------WF---HLAI-FDFFTWLGYLNSLINPIIY >ACM1_HUMAN/42-418 GNLLVLISFKV-N--TE--LK---T-V--NNYFLLSLACADLIIGTFSMNLYTT-Y-------L-L-M---- -GHWAL--GT---LACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAK-RTPR--RAALMIGLAWL VSFVL-WA-PAILFWQY---LVG-ER----------TV---------L--AGQCYIQ-------------FL SQ-PIITFGTAMAA--F-YLPVT-------VMCTLYWRIYRETENRARE----------------------- ---LA------A------LQ-G--------SETPGK-----------G--GGSS-----SS--SERSQ---- -----------------------------------------------------------PGAEGSPE----- ----------------------------------------------------TPP----------------- ---------G-------------------------------------------------------------- ------------------------------------------------------------------------ ----RCCRCCRAPRLLQAYSWKEEEEE---------DEGSME-SLTSSEGE--------------------- ----------------------------------------EPGSEVVIKMPMVD--PEAQ-------APTKQ --PPRSS--PN-TVKRPTKKGRDRAGKGQKPR-GK-EQ---L-------A-K--R--KT------------- --------------------------------------FSLVK--EKKAARTLSAILLAFILTWTPYNIMVL VSTFCK-D-----------CV---PETL-WELGYWLCYVNSTINPMCY >ADA1D_HUMAN/113-402 GNLLVILSVAC-N--RH--LQ---T-V--TNYFIVNLAVADLLLSATVLPFSAT-M-------E-V-L---- -GFWAF--GR---AFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAI-MTER--KAAAILALLWV VALVV-SVGP-LLGWKE----PV-P----P------D-------------ERFCGIT--------------- EE-AGYAVFSSVCS--F-YLPMA-------VIVVMYCRVYVVARSTTRS----------------------- ---LE------A------GVKR--------ERG--K------------------------A----SEV---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------VLRIHC--------------R----------GAATG-A------------D GAH-----GMRSA----------------KGH-TF-RS---S-------L-S--V----------------- ------------------------------------RLLKFSR--EKKAAKTLAIVVGVFVLCWFPFFFVLP LGSLFP-QL-K---------P---SEGV-FKVIFWLGYFNSCVNPLIY >DRD2_BOVIN/51-427 GNVLVCMAVSR-E--KA--LQ---T-T--TNYLIVSLAVADLLVATLVMPWVVY-L-------E-V-V---- -GEWKF--SR---IHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKR--RVTVMIAIVWV LSFTI-SCPM-LF-GLN---NTD-QN--------------------------ECII---------------A -N-PAFVVYSSIVS--F-YVPFI-------VTLLVYIKIYIVLRRRRKR-VNTKRSSRAFRA---------- ------------------------------NLK--A--------------PLKGNCTHPEDMK--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------LCTVIM-KSNGSFPVN-------------RRRV----------------- ------------------------------EAARRAQELEME-MLSSTSPP--------------------- ---------------------------------ERTRYSPIPP----------------SHHQLTLPDPSHH G--LHST--PD-SPAKPEKNG---------------HA---K------TV-N--P--KIAKIFEIQSMPNGK --------------------------TRTSLKTMSRRKLSQQK--EKKATQMLAIVLGVFIICWLPFFITHI LNIHCD-C-----------NI---PPVL-YSAFTWLGYVNSAVNPIIY >5HT2A_HUMAN/91-380 GNILVIMAVSL-E--KK--LQ---N-A--TNYFLMSLAIADMLLGFLVMPVSML-T-------I-LYG---- -YRWPL--PS---KLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRF-NSRT--KAFLKIIAVWT ISVGI-SMPI-PVFGLQ---DDS-K----V-----F-----------K--EGSCLL---------------- AD-DNFVLIGSFVS--F-FIPL-------TIMVITYFLTIKSLQ----KE---------------------- -----------------------ATL-C----------V-S--DLGTR--AKLA-----SF----SFL---- -----------------------------------------------------------------P------ -----------------------------------------------------QS----------------- ----------S------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------LSS------------------------- ----------------------------------------------------------------EKLFQRSI HREP-------------G-------------------S----------YT-G-------------------- ----------------------------------RRTMQSISN--EQKACKVLGIVFFLFVVMWCPFFITNI MAVICK-ES------CNE-DV---IGAL-LNVFVWIGYLSSAVNPLVY >A0A8R1I4B6_CAEJA/18-649 GNLMVFYVILT-K--KS--LQ---T-S--TNRLVLSLTISDLLLGILILPFAII-Q-------E-H-T---- -NEWLF--GH---VGCRLWLSVDVFLSTASIYNLLAISFDRVVRLMTF--------------------LVWF CSLLL-AVVL-FVLETV---NAQ-DT---M------P-------------TKDCQPT--------------T LP-SMYIIFSAVAS--F-IAPAF-------VMVILNARIFQTVLHTSRT-MTVKSK-----NGSLRVHRRKD PIIPV--KKLEK------YE-S--------RMS--Q--------------EEEGVGTPPKDKKLSDPVPVLV VESHKNSMDAPAIRTFLTHTVVFGVLEAKKTNIINHITHQIYRILKNNRDDDGVVHRQSPGR---PRTTSRA MDRNILRACREDPRRTSTDNPVSVTSPNEPVPSRRTIRRRLQVAGLHGRRPVKKPLVSLKNRTARVEWAKQH LSWGPREWANHI---WSDESKFNLFGTDGIQWIRRPIGSRYAPQYQCPTVKHEGGSVMVWGCFPDTSMGPLK RIVGTMGRYVYEDILENTMRLWARANLGRSWVFQQDNDPKHTSGHVANWFRRRRVDLLGWPSQSPDLN---- ---PIEQMWEEL--------------ERRLKGV------------R-------------------------- ------------------------------------------------------------------------ -------------------------------------A---S------NA-N--Q--KFAQLEA------AW KSIPMTVVQTLLDSMPRRCQAVIDAKGYPT--KKKVMRRSLRT--EMRVARTTGIVVAAFIVCWIPFTTIYV LQAYSV-CTVA--AG----CI---PTSL-FTIAFWLGYSNSAVNPILY >CNR2_HUMAN/50-299 ENVAVLYLILS-S--HQ--LRR--K-P--SYLFIGSLAGADFLASVVFACSFVN-F-------H--VFH--- ---GVD--SK---AVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKAL-LTRG--RALVTLGIMWV LSALV-SYLP-LMGWTC---CPR-----------------------------PCSEL-----------FPLI -P-NDYLLSWLL-F--I-AFLF-------SGIIYTYGHVLWKAHQHV-ASL--------------------- ----S------G--------------------------------HQ-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------DR---------------------- ---------------------------------QVPGMARMRL--DVRLAKTLGLVLAVLLICWFPVLALMA HSLATT-LS------D---QV----KK-AFAFCSMLCLINSMVNPVIY >CNR1_HUMAN/133-397 ENLLVLCVILH-S--RS--LRC--R-P--SYHFIGSLAVADLLGSVIFVYSFID-F-------H--VFH--- ---RKD--SR---NVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRI-VTRP--KAVVAFCLMWT IAIVI-AVLP-LLGWNC---EKL-QS--------------------------VCSDI-----------FPHI -D-ETYLMFWIG-V--T-SVLL-------LFIVYAYMYILWKAHSHAVRMI--------------------- ----Q------R------GTQKSIII-H-T----------S--EDG-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------KV---------------------- ---------------------------------QVTRPDQARM--DIRLAKTLVLILVVLIICWGPLLAIMV YDVFGK-MN------K---LI----KT-VFAFCSMLCLLNSTVNPIIY >S1PR1_HUMAN/62-311 ENIFVLLTIWK-T--KK--FH---R-P--MYYFIGNLALSDLLAGVAYTANLLL-S-------G--ATT--- ---YKL--TP---AQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHN-G-SNNF--RLFLLISACWV ISLIL-GGLP-IMGWNC---ISA-LS--------------------------SCSTV-----------LPLY -H-KHYILFCTT-V--F-TLLL-------LSIVILYCRIYSLVRTRS-RRL--------------------- ----T--------------------F-R-K------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------N-ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLL LDVGCK-VK------T-CDIL-----F-RAEYFLVLAVLNSGTNPIIY >MC3R_MOUSE/55-299 ENILVILAVVR-N--GN--LH---S-P--MYFFLCSLAAADMLVSLSNSLETIMIA-------V-I-NSDSL TLEDQF--IQ---HMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSI-MTVR--KALTLIGVIWV CCGIC-GVMF-I-IYSE---SK-------------------------------------------------- -----MVIVCLITM--F-FAMV-------LLMGTLYIHMFLFARLHVQRI---------------------- ------------------------AV-L----------P----PAGV------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------VA-PQQHS--CMKGAVTITILLGVFIFCWAPFFLHLV LIITCP---------TNPYCI---CYTAHFNTYLVLIMCNSVIDPLIY >AA1R_BOVIN/26-288 GNVLVIWAVKV-N--QA--LR---D-A--TFCFIVSLAVADVAVGALVIPLAIL-I--------NI-G---- -PRTYF--H-----TCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTV-VTPR--RAVVAITGCWI LSFVV-GLTP-MFGWNN---LSA--V---------ERDWLANGSVGEP--VIECQFE-------------KV IS-MEYMVYFNFFV--WVLPPLL-------LMVLIYMEVFYLIRKQLNKK---------------------- ---V-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------SAS-------------- ---------------------------------SGDPQKYYGK--ELKIAKSLALILFLFALSWLPLHILNC ITLFCP-----------SCHM---PRIL-IYIAIFLSHGNSAMNPIVY >V2R_HUMAN/54-325 SNGLVLAALAR-R--GRRGHW---A-P--IHVFIGHLCLADLAVALFQVLPQLA-W--------KA-T---- -DRFRG--PDA---LCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRH-GSGA--HWNRPVLVAWA FSLLL-SLPQ-LFIFAQ---RNV--E---------GGS---------G--VTDCWACFAE----------PW GR-RTYVTWIALMV--F-VAPTL-------GIAACQVLIFREIHASLVPG---------------------- ---PSERPGGRRRGRRTGS----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------PGEGAHVSAA--VAKTVRMTLVIVVVYVLCWAPFFLVQL WAAWDP-----------EAPL---EGAP-FVLLMLLASLNSCTNPWIY >TRFR_HUMAN/42-320 GNIMVVLVVMR-T--KH--MR---T-P--TNCYLVSLAVADLMVLVAAGLPNIT-D-------S-I-Y---- -GSWVY--GY---VGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFL-CTFS--RAKKIIIFVWA FTSLY-CMLW-FFLLDL---NIS-T----Y-----KDA---------I--VISCGYKI-S--R------N-Y YS-P-IYLMDFGVF--Y-VVPMI-------LATVLYGFIARILF----LN---------------------- -----------------------PIPSDPKENSKTWKNDST--HQN-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---T-------------NL-----------------NV----------NT-S-------------------- ---------------------------------NRCFNSTVSS--RKQVTKMLAVVVILFALLWMPYRTLVV VNSFLS-SP-------FQEN------W-FLLFCRICIYLNSAINPVIY >NTR1_HUMAN/80-364 GNTVTAFTLAR-K--KS--LQSLQS-T--VHYHLGSLALSDLLTLLLAMPVELY-N-------F-IWVH--- -HPWAF--GD---AGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTL-MSRS--RTKKFISAIWL ASALL-A-VP-MLFTMG---EQN-RS---A-----DGQ-------HAG--GLVCTPT-----------IHTA TV-KVVIQVNTFMS--F-IFPM-------VVISVLNTIIANKLTVMV-RQA--------------------- ----A----------------------E-Q--G---QVC-T--VGG-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------EH-S-TF--SM------------- ---------------------------------A-IEPGRVQA--LRHGVRVLRAVVIAFVVCWLPYHVRRL MFCYIS-DE------QWTPFLYDFYHY-FYMVTNALFYVSSTINPILY >UL33_HCMVM/50-306 NAIVLITQLLT-N--RV--LGY--S-T--PTIYMTNLYSTNFLTLT-VLPFIVL-------------S---- -NQWLLPASVA---SCKFLSVIYYSSCTVGFATVALIAADRYRVLHKRTYA--R-QSYR--STYIILLLTWF AGLIF-SMPA-AVYTTV---VIH-NGTNGQ-----SSN---------G--HATCVLYFIA--D-----EVYT VL-LSWKVLLTLVW--G-AAPVI-------MMTWFYAFFYSTVQRA-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------SQKQ--RSRTLTFVSVLLISFVALQTPYVSIMI FNSYAT-AAWP--MDCEHLTL---RRTI-GTLSRLVPHLHCLINPILY >C5AR1_CANLF/55-302 GNFLVVWVTGF----EV--RR---T-I--NAIWFLNLAVADLLSCL-ALPILFSSI-------V-Q-Q---- -GYWPF--GNA---ACRILPSLILLNMYASILLLTTISADRFVLVFNPIWCQNY-RGPQ--LAWAACSVAWA VALLL-TVPS-FIFRGV---HT-------E-----YFP---------F--WMTCGVDYSG--V-----GV-L VE-RGVAILRLLMG--F-LGPLV-------ILSICYTFLLIRTWSR-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------KATR--STKTLKVVVAVVVSFFVLWLPYQVTGM MMALFY-KH------SESFRR---VSRL-DSLCVAVAYINCCINPIIY >GP182_RAT/66-316 ENVLVICVNCR-R--SG--RV---G-M--LNLYILNMAVADLGIIL-SLPVWMLEV-------M-L-E---- -YTWLW--GSF---SCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQR-HQHR--IRRAVCAGVWV LSAII-PLPE-VVHIQL---L-D-G----------------------S--EPMCLFLAPF--E-----TYSA WA-LAVALSATILG--F-LLPFP-------LIAVFNILSACRLRRQG------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------QTE--SRRHCLLMWAYIVVFVICWLPYHVTML LLTLHT-THIF--LHCNLVNF---LYFF-YEIIDCFSMLHCVANPILY >ACKR3_CANLF/61-315 ANSVVVWVNIQ-A--KT--TG---Y-D--THCYILNLAIADLWVVV-TIPVWVVSL-------V-Q-H---- -NQWPM--GEL---TCKITHLIFSINLFGSIFFLTCMSVDRYLSITYFASTSSR-RKKV--VRRAVCVLVWL LAFCV-SLPD-TYYLKT---VTS-AS-----------N---------N--ETYCRSFYPE--H-----SVKE WL-ISMELVSVVLG--F-AIPFC-------VIAVFYCLLARAISASS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------DQE--KQSSRKIIFSYVVVFLVCWLPYHVVVL LDIFSI-LHYIP-FTCQLENF---LFTA-LHVTQCLSLVHCCVNPVLY >CXCR1_HUMAN/56-305 GNSLVMLVILY-S--RV--GR---S-V--TDVYLLNLALADLLFAL-TLPIWAA-S-------K-V------ -NGWIF--GTF---LCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQ-KRH---LVKFVCLGCWG LSMNL-SLPF-FLFRQA---YHP-N-----------N----------S--SPVCYEVLGN--D-----T-AK WR-MVLRILPHTFG--F-IVPLF-------VMLFCYGFTLRTLFKAH------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------MGQ--KHRAMRVIFAVVLIFLLCWLPYNLVLL ADTLMR-TQVIQ-ESCERRNN---IGRA-LDATEILGFLHSCLNPIIY >ACKR4_BOVIN/58-303 GNSTVVAIYAY-Y--KK--RR---T-K--TDVYILNLAVADLFLLF-TLPFWAV-N-------A-V------ -HGWVL--GKI---MCKVTSALYTVNFVSGMQFLACISTDRYWAVTKAPSQSGV-GKP----CWVICFCVWV AAILL-SIPQ-LVFYTV---NHK----------------------------ARCVPIFPY--H-----LGTS MK-ASIQILEICIG--F-IIPFL-------IMAVCYFITAKTLIKMP------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------NIK--KSQPLKVLFTVVIVFIVTQLPYNIVKF CQAIDI-IYSLI-TDCDMSKR---MDVA-IQITESIALFHSCLNPVLY >CCR7_HUMAN/75-326 GNGLVVLTYIY-F--KR--LK---T-M--TDTYLLNLAVADILFLL-TLPFWAY-S-------A-A------ -KSWVF--GVH---FCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRH-RARVLLISKLSCVGIWI LATVL-SIPE-LLYSDL---QRS-S-----------SE---------Q--AMRCSLITEH----------VE AF-ITIQVAQMVIG--F-LVPLL-------AMSFCYLVIIRTLLQAR------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------NFE--RNKAIKVIIAVVVVFIVFQLPYNGVVL AQTVAN-FNITS-STCELSKQ---LNIA-YDVTYSLACVRCCVNPFLY >CXCR4_BOVIN/56-303 GNGLVILVMGY-Q--KK--LR---S-M--TDKYRLHLSVADLLFVL-TLPFWAV-D-------A-V------ -ANWYF--GKF---LCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQKP-RKLL--AEKVVYVGVWL PAVLL-TIPD-LIFADI---KEV-D-----------E-------------RYICDRFYPS----------DL WL-VVFQFQHIVVG--L-LLPGI-------VILSCYCIIISKLSHSK------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------GYQ--KRKALKTTVILILTFFACWLPYYIGIS IDSFIL-LEIIQ-QGCEFEST---VHKW-ISITEALAFFHCCLNPILY >CXCR5_HUMAN/68-322 GNVLVLVILER-H--RQ--TR---S-S--TETFLFHLAVADLLLVF-ILPFAVA-E-------G-S------ -VGWVL--GTF---LCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRH-RRLL--SIHITCGTIWL VGFLL-ALPE-ILFAKV---SQG-H----------HNN---------S--LPRCTFSQEN--Q-----AETH AW-FTSRFLYHVAG--F-LLPML-------VMGWCYVGVVHRLRQAQ------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------RRPQ--RQKAVRVAILVTSIFFLCWSPYHIVIF LDTLAR-LKAVD-NTCKLNGS---LPVA-ITMCEFLGLAHCCLNPMLY >CX3C1_RAT/49-294 GNLLVVLALTN-S--RK--SK---S-I--TDIYLLNLALSDLLFVA-TLPFWTH-Y-------L-I------ -SHEGL--HNA---MCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNN-RTVQ--HGVTISLGVWA AAILV-ASPQ-FMFTKR---KD-----------------------------NECLGDYPE--V-----LQEI WP-VLRNSEVNILG--F-VLPLL-------IMSFCYFRIVRTLFSC-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------KNRK--KARAIRLILLVVVVFFLFWTPYNIVIF LETLKF-YNFF--PSCGMKRD---LRWA-LSVTETVAFSHCCLNPFIY >US28_HCMVM/50-291 GNFLVIFTITW-R--RR--IQ---C-S--GDVYFINLAAADLLFVC-TLPLWMQ-Y-------L-L-D---- --HNSL--ASV---PCTLLTACFYVAMFASLCFITEIALDRYYAIVYM-RY----RPVK--QACLFSIFWWI FAVII-AIPH-FMVVTK---KD-----------------------------NQCMTDYDY--L------EVS YP-IILNVELMLGA--F-VIPLS-------VISYCYYRISRIVAVSQ------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------SRH--KGRIVRVLIAVVLVFIIFWLPYHLTLF VDTLKL-LKWIS-SSCEFERS---LKRA-LILTESLAFCHCCLNPLLY >US27_HCMVM/50-296 NMLVITTILYY-R--RK--KK---S-P--SDTYICNLAVADLLIVV-GLPFFLE-Y-------A-K-H---- -HPKLS--REV---VCSGLNACFYICLFAGVCFLINLSMDRYCVIVWGVELNRV-RNNK--RATCWVVIFWI LAALM-GMPH-YLMYSH---TN-----------------------------NECVGEFAN--E-----TSGW FP-VFLNTKVNICG--Y-LAPIV-------LMAYTYNRMVRFIINYV------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------GKW--HMQTLHVLLVVVVSFASFWFPFNLALF LESIRL-LSGTQ--NETLQTV---ITFC-LYVGQFLAYVRACLNPGIY >CCR1_HUMAN/51-301 GNILVVLVLVQ-Y--KR--LK---N-M--TSIYLLNLAISDLLFLF-TLPFWID-Y-------K-L-K---- -DDWVF--GDA---MCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRA-RTVT--FGVITSIIIWA LAILA-SMPG-LYFSKT---QWE--------------F---------T--HHTCSLHFPH--E-----SLRE WK-LFQALKLNLFG--L-VLPLL-------VMIICYTGIIKILLRR-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------PNEK--KSKAVRLIFVIMIIFFLFWTPYNLTIL ISVFQD-FLFT--HECEQSRH---LDLA-VQVTEVIAYTHCCVNPVIY >BKRB2_HUMAN/74-332 ENIFVLSVFCL-H--KS--SC---T-V--AEIYLGNLAAADLILAC-GLPFWAITI-------S-N-N---- -FDWLF--GET---LCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRM-RGVR--WAKLYSLVIWG CTLLL-SSPM-LVFRTM---KEY-SD---------EGH---------N--VTACVISYPS----------LI WE-VFTNMLLNVVG--F-LLPLS-------VITFCTMQIMQVLRNNEMQ----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------KFKEIQT--ERRATVLVLVVLLLFIICWLPFQISTF LDTLHR-LGIL--SSCQDERI---IDVI-TQIASFMAYSNSCLNPLVY >AGTR1_BOVIN/45-302 GNSLVVIVIYF-Y--MK--LK---T-V--ASVFLLNLALADLCFLL-TLPLWAVYT-------A-M-E---- -YRWPF--GNY---LCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLR-RTML--VAKVTCIIIWL LAGLA-SLPT-IIHRNV---FFI------------ENT---------N--ITVCAFHYES--------QNST LP-VGLGLTKNILG--F-LFPFL-------IILTSYTLIWKTLKKAYEI----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------Q-------------------- --------------------------------------KNKPR--KDDIFKIILAIVLFFFFSWVPHQIFTF MDVLIQ-LGLI--RDCKIEDI---VDTA-MPITICLAYFNNCLNPLFY >AGTR2_MOUSE/61-318 VNIVVVSLFCC-Q--KG--PK---K-V--SSIYIFNLALADLLLLA-TLPLWATYY-------S-Y-R---- -YDWLF--GPV---MCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQR--RNPW--QASYVVPLVWC MACLS-SLPT-FYFRDV---RTI-EY-----------L---------G--VNACIMAFPP--E-----KYAQ WS-AGIALMKNILG--F-IIPLI-------FIATCYFGIRKHLLKTNSY----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------GKNRIT--RDQVLKMAAAVVLAFIICWLPFHVLTF LDALTW-MGII--NSCEVIAV---IDLA-LPFAILLGFTNSCVNPFLY >GP183_HUMAN/48-308 GNLLALVVIVQ-N--RK--KI---N-S--TTLYSTNLVISDILFTT-ALPTRIAYY-------A-M-G---- -FDWRI--GDA---LCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKI-KRIE--HAKGVCIFVWI LVFAQ-TLPL-LINPMS---KQ--E-----------A----------E--RITCME-YPN--F-----EETK SL-PWILLGACFIG--Y-VLPLI-------IILICYSQICCKLFRTAKQ----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------N----------------- -----------------------------------PLTEKSGV--NKKALNTIILIIVVFVLCFTPYHVAII QHMIKK-LRFSNFLECSQRHS---FQIS-LHFTVCLMNFNCCMDPFIY >LPAR6_CHICK/31-288 ANCVAIYIFTF-T--LK--VR---N-E--TTTYMLNLAISDLLFVF-TLPFRIY-Y-------F-V-V---- -RNWPF--GDV---LCKISVTLFYTNMYGSILFLTCISVDRFLAIVHPFRSKTL-RTKR--NARIVCVAVWI TVLAG-STPA-SFFQST---NRQ-N-----------NT---------E--QRTCFENFPE--S-----TWKT YL-SRIVIFIEIVG--F-FIPLI-------LNVTCSTMVLRTLNKPLT------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------LSRNKLS--KKKVLKMIFVHLVIFCFCFVPYNITLI LYSLMR-TQTW--INCSVVTA---VRTM-YPVTLCIAVSNCCFDPIVY >G3H330_CRIGR/91-342 -NILAIAVFVL-K--MK--VK---K-P--AVVYMLHLAMADVLFVSVL-PLKIS-Y-------Y-FSG---- -SDWQF--GS---GMCRFATAAFYCNMYASIMLMTVISIDRFLAVVYPIQSLSW-RTLG--RANFTCLVIWV MAIMG-VVPL-LLKE-Q---T-T-R----V-----PGL---------N--ITTCHDVLNE--T----LLQGF YS-Y-YFSAFSAVF--F-LVPLI-------ISTICYMSIIRCLS----SS---------------------- -----------------------S------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------VANRSK--KSRALFLSAAVFCVFIVCFGPTNVLLI MHYLLL-SD------SPATEK---AYF-AYLLCVCVSSVSCCIDPLIY >PTAFR_CAVPO/32-293 ANGYVLWVFAR-LYPSK--KL---N-E--IKIFMVNLTVADLLFLI-TLPLWIVYY-------S-N-Q---- -GNWFL--PKF---LCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQA-TTRK--RGIALSLVIWV AIVAA-ASYF-LVMDST---NVV-S--NKA-----GSG---------N--ITRCFEHYEK--G------S-- KP-VLIIHICIVLG--F-FIVFL-------LILFCNLVIIHTLLRQPVK----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------QQRNAEV--RRRALWMVCTVLAVFVICFVPHHMVQL PWTLAE-LGMW--P-SSNHQA---INDA-HQVTLCLLSTNCVLDPVIY >APJ_HUMAN/45-309 GNGLVLWTVFRSS--RE--KR---R-S--ADIFIASLAVADLTFVV-TLPLWATYT-------Y-R-D---- -YDWPF--GTF---FCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARL-RLRV--SGAVATAVLWV LAALL-AMPV-MVLRTT---GDL-EN-----------T---------T--KVQCYMDYSM--V-ATVSSEWA WE-VGLGVSSTTVG--F-VVPFT-------IMLTCYFFIAQTIAGHFRK----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------ERIEGLRK--RRRLLSIIVVLVVTFALCWMPYHLVKT LYMLGS-LLH---WPCDFDLF---LMNI-FPYCTCISYVNSCLNPFLY >OPRD_MOUSE/66-318 GNVLVMFGIVR-Y--TK--LK---T-A--TNIYIFNLALADALATSTL-PFQSA-K-------Y-L-M---- -ETWPF--GE---LLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF-RTPA--KAKLINICIWV LASGV-GVPI-MVMA-V---T-Q-P----R-----DGA---------V----VCMLQFPS--P------SWY WD-TVTKICVFLFA--F-VVPIL-------IITVCYGLMLLRLR----SV---------------------- -----------------------RLLS--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------GSKEKDRS--LRRITRMVLVVVGAFVVCWAPIHIFVI VWTLVD-IN-------RRDPL---VVA-ALHLCIALGYANSSLNPVLY >SSR1_HUMAN/75-323 GNSMVIYVILR-Y--AK--MK---T-A--TNIYILNLAIADELLML-SVPFLVTS--------T-L-L---- -RHWPF--GAL---LCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARY-RRPT--VAKVVNLGVWV LSLLV-ILPI-VVFSRT---AAN-SD---------------------G--TVACNMLMPE--P-----A-QR WL-VGFVLYTFLMG--F-LLPVG-------AICLCYVLIIAKMRMVALK----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------A----------------- -----------------------------------GWQQRKRS--ERKITLMVMMVVMVFVICWMPFYVVQL VNVFAE-----------QDD-----ATV-SQLSVILGYANSCANPILY