ID STRAB_HUMAN Reviewed; 418 AA. AC Q9C0K7; Q5BKY7; Q9P1L0; DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 03-MAR-2009, entry version 64. DE RecName: Full=STE20-related kinase adapter protein beta; DE Short=STRAD beta; DE AltName: Full=Pseudokinase ALS2CR2; DE AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; DE AltName: Full=ILP-interacting protein; DE AltName: Full=CALS-21; GN Name=STRADB; Synonyms=ALS2CR2, ILPIP; ORFNames=PRO1038; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RX MEDLINE=21100893; PubMed=11161814; DOI=10.1006/geno.2000.6392; RA Hadano S., Yanagisawa Y., Skaug J., Fichter K., Nasir J., RA Martindale D., Koop B.F., Scherer S.W., Nicholson D.W., Rouleau G.A., RA Ikeda J.-E., Hayden M.R.; RT "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, RT and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) RT critical region at chromosome 2q33-q34: candidate genes for ALS2."; RL Genomics 71:200-213(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY, AND RP INTERACTION WITH BIRC4. RX MEDLINE=22172817; PubMed=12048196; DOI=10.1074/jbc.M203312200; RA Sanna M.G., Da Silva Correia J., Luo Y., Chuang B., Paulson L.M., RA Nguyen B., Deveraux Q.L., Ulevitch R.J.; RT "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated RT activation of JNK1 and protection against apoptosis."; RL J. Biol. Chem. 277:30454-30462(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Fetal liver; RA Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., RA Liu M., He F.; RT "Functional prediction of the coding sequences of 121 new genes RT deduced by analysis of cDNA clones from human fetal liver."; RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH STK11 AND CAB39. RX PubMed=14517248; DOI=10.1093/emboj/cdg490; RA Boudeau J., Baas A.F., Deak M., Morrice N.A., Kieloch A., RA Schutkowski M., Prescott A.R., Clevers H.C., Alessi D.R.; RT "MO25alpha/beta interact with STRADalpha/beta enhancing their ability RT to bind, activate and localize LKB1 in the cytoplasm."; RL EMBO J. 22:5102-5114(2003). RN [8] RP VARIANTS [LARGE SCALE ANALYSIS] GLU-155 AND LEU-386. RX PubMed=17344846; DOI=10.1038/nature05610; RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., RA Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., RA O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., RA Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., RA Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., RA Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., RA Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., RA West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., RA Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., RA DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., RA Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., RA Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.; RT "Patterns of somatic mutation in human cancer genomes."; RL Nature 446:153-158(2007). CC -!- FUNCTION: Pseudokinase which, in complex with CAB39, binds to and CC activates STK11. Relocates STK11 from the nucleus to the CC cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle CC arrest. CC -!- SUBUNIT: Interacts with BIRC4/XIAP. These two proteins are likely CC to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2. CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; Synonyms=ILPIP-alpha; CC IsoId=Q9C0K7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9C0K7-2; Sequence=VSP_016623, VSP_016624; CC Note=No experimental confirmation available; CC Name=3; Synonyms=ILPIP-beta; CC IsoId=Q9C0K7-3; Sequence=VSP_016625; CC -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, CC testis, liver and colon. CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically CC inactive. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr CC protein kinase family. STE20 subfamily. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC -!- CAUTION: Ser-184 is present instead of the conserved Asp which is CC expected to be an active site residue. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB038950; BAB32500.1; -; mRNA. DR EMBL; AY093697; AAM19143.1; -; mRNA. DR EMBL; AF116618; AAF71042.1; -; mRNA. DR EMBL; AK027637; BAB55254.1; -; mRNA. DR EMBL; AC007282; AAY14692.1; -; Genomic_DNA. DR EMBL; BC008302; AAH08302.1; -; mRNA. DR EMBL; BC090871; AAH90871.1; -; mRNA. DR IPI; IPI00032099; -. DR IPI; IPI00657901; -. DR IPI; IPI00658041; -. DR RefSeq; NP_061041.2; -. DR UniGene; Hs.652338; -. DR IntAct; Q9C0K7; 3. DR PhosphoSite; Q9C0K7; -. DR PRIDE; Q9C0K7; -. DR Ensembl; ENSG00000082146; Homo sapiens. DR GeneID; 55437; -. DR KEGG; hsa:55437; -. DR GeneCards; GC02P202025; -. DR H-InvDB; HIX0002739; -. DR H-InvDB; HIX0029700; -. DR HGNC; HGNC:13205; STRADB. DR MIM; 607333; gene. DR PharmGKB; PA24743; -. DR HOGENOM; Q9C0K7; -. DR HOVERGEN; Q9C0K7; -. DR LinkHub; Q9C0K7; -. DR NextBio; 59838; -. DR Bgee; Q9C0K7; -. DR CleanEx; HS_ALS2CR2; -. DR GermOnline; ENSG00000082146; Homo sapiens. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0005524; F:ATP binding; NAS:UniProtKB. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR GO; GO:0032147; P:activation of protein kinase activity; IDA:UniProtKB. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro. DR GO; GO:0006611; P:protein export from nucleus; IDA:UniProtKB. DR InterPro; IPR000719; Prot_kinase_core. DR InterPro; IPR017441; Protein_kinase_ATP_bd_CS. DR InterPro; IPR017442; Se/Thr_pkinase-rel. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR Pfam; PF00069; Pkinase; 1. DR ProDom; PD000001; Prot_kinase; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; FALSE_NEG. PE 1: Evidence at protein level; KW Alternative splicing; ATP-binding; Cell cycle; Cytoplasm; KW Nucleotide-binding; Nucleus; Polymorphism. FT CHAIN 1 418 STE20-related kinase adapter protein FT beta. FT /FTId=PRO_0000085617. FT DOMAIN 58 369 Protein kinase. FT NP_BIND 64 72 ATP (By similarity). FT BINDING 89 89 ATP (By similarity). FT VAR_SEQ 1 138 Missing (in isoform 3). FT /FTId=VSP_016625. FT VAR_SEQ 372 377 MKEESQ -> PYFEFL (in isoform 2). FT /FTId=VSP_016623. FT VAR_SEQ 378 418 Missing (in isoform 2). FT /FTId=VSP_016624. FT VARIANT 155 155 G -> E (in a metastatic melanoma sample; FT somatic mutation). FT /FTId=VAR_041335. FT VARIANT 386 386 P -> L. FT /FTId=VAR_041336. SQ SEQUENCE 418 AA; 47026 MW; A63ED6CCE1E18C96 CRC64; MSLLDCFCTS RTQVESLRPE KQSETSIHQY LVDEPTLSWS RPSTRASEVL CSTNVSHYEL QVEIGRGFDN LTSVHLARHT PTGTLVTIKI TNLENCNEER LKALQKAVIL SHFFRHPNIT TYWTVFTVGS WLWVISPFMA YGSASQLLRT YFPEGMSETL IRNILFGAVR GLNYLHQNGC IHRSIKASHI LISGDGLVTL SGLSHLHSLV KHGQRHRAVY DFPQFSTSVQ PWLSPELLRQ DLHGYNVKSD IYSVGITACE LASGQVPFQD MHRTQMLLQK LKGPPYSPLD ISIFPQSESR MKNSQSGVDS GIGESVLVSS GTHTVNSDRL HTPSSKTFSP AFFSLVQLCL QQDPEKRPSA SSLLSHVFFK QMKEESQDSI LSLLPPAYNK PSISLPPVLP WTEPECDFPD EKDSYWEF //