Analysis Type: PANTHER Overrepresentation Test (Released 20240226) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.10536401 Released 2024-01-17 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20592) upload_1 (38) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) tyrosine catabolic process (GO:0006572) 6 6 .01 + > 100 2.61E-17 3.62E-14 aspartate biosynthetic process (GO:0006532) 3 3 .01 + > 100 5.80E-09 1.38E-06 epinephrine biosynthetic process (GO:0042418) 2 2 .00 + > 100 3.32E-06 5.32E-04 glutamate catabolic process to 2-oxoglutarate (GO:0019551) 2 2 .00 + > 100 3.32E-06 5.27E-04 glutamate catabolic process to aspartate (GO:0019550) 2 2 .00 + > 100 3.32E-06 5.21E-04 ethanol oxidation (GO:0006069) 9 7 .02 + > 100 1.46E-18 2.47E-15 L-phenylalanine catabolic process (GO:0006559) 8 6 .01 + > 100 7.29E-16 6.94E-13 L-phenylalanine metabolic process (GO:0006558) 8 6 .01 + > 100 7.29E-16 6.53E-13 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) 8 6 .01 + > 100 7.29E-16 6.17E-13 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) 8 6 .01 + > 100 7.29E-16 5.85E-13 aspartate catabolic process (GO:0006533) 3 2 .01 + > 100 9.94E-06 1.43E-03 fumarate metabolic process (GO:0006106) 3 2 .01 + > 100 9.94E-06 1.42E-03 epinephrine metabolic process (GO:0042414) 3 2 .01 + > 100 9.94E-06 1.40E-03 formaldehyde catabolic process (GO:0046294) 3 2 .01 + > 100 9.94E-06 1.39E-03 tyrosine metabolic process (GO:0006570) 17 9 .03 + > 100 2.14E-21 5.44E-18 fatty acid omega-oxidation (GO:0010430) 6 3 .01 + > 100 1.16E-07 2.35E-05 melanin biosynthetic process from tyrosine (GO:0006583) 4 2 .01 + > 100 1.98E-05 2.63E-03 formaldehyde metabolic process (GO:0046292) 4 2 .01 + > 100 1.98E-05 2.61E-03 ethanol metabolic process (GO:0006067) 20 9 .04 + > 100 1.47E-20 3.21E-17 phenol-containing compound catabolic process (GO:0019336) 12 5 .02 + > 100 1.28E-11 5.26E-09 catecholamine catabolic process (GO:0042424) 10 4 .02 + > 100 2.05E-09 5.40E-07 dopamine catabolic process (GO:0042420) 10 4 .02 + > 100 2.05E-09 5.30E-07 catechol-containing compound catabolic process (GO:0019614) 10 4 .02 + > 100 2.05E-09 5.22E-07 aspartate metabolic process (GO:0006531) 8 3 .01 + > 100 3.23E-07 6.30E-05 aromatic amino acid family catabolic process (GO:0009074) 16 6 .03 + > 100 2.06E-13 1.01E-10 response to blue light (GO:0009637) 6 2 .01 + > 100 4.95E-05 6.24E-03 aromatic amino acid metabolic process (GO:0009072) 31 9 .06 + > 100 1.75E-18 2.66E-15 ethanol catabolic process (GO:0006068) 12 3 .02 + > 100 1.26E-06 2.32E-04 dicarboxylic acid biosynthetic process (GO:0043650) 12 3 .02 + > 100 1.26E-06 2.29E-04 glutamate catabolic process (GO:0006538) 8 2 .01 + > 100 9.22E-05 1.11E-02 norepinephrine biosynthetic process (GO:0042421) 8 2 .01 + > 100 9.22E-05 1.10E-02 catechol-containing compound biosynthetic process (GO:0009713) 21 5 .04 + > 100 3.24E-10 1.01E-07 catecholamine biosynthetic process (GO:0042423) 21 5 .04 + > 100 3.24E-10 9.88E-08 cellular detoxification of aldehyde (GO:0110095) 9 2 .02 + > 100 1.18E-04 1.39E-02 oxaloacetate metabolic process (GO:0006107) 9 2 .02 + > 100 1.18E-04 1.38E-02 dopamine biosynthetic process (GO:0042416) 9 2 .02 + > 100 1.18E-04 1.37E-02 phenol-containing compound biosynthetic process (GO:0046189) 37 8 .07 + > 100 2.27E-15 1.44E-12 melanin biosynthetic process (GO:0042438) 14 3 .03 + > 100 2.08E-06 3.60E-04 amine catabolic process (GO:0009310) 20 4 .04 + > 100 4.68E-08 9.90E-06 cellular biogenic amine catabolic process (GO:0042402) 20 4 .04 + > 100 4.68E-08 9.76E-06 aldehyde catabolic process (GO:0046185) 15 3 .03 + > 100 2.60E-06 4.45E-04 melanin metabolic process (GO:0006582) 15 3 .03 + > 100 2.60E-06 4.40E-04 norepinephrine metabolic process (GO:0042415) 15 3 .03 + > 100 2.60E-06 4.35E-04 primary alcohol catabolic process (GO:0034310) 15 3 .03 + > 100 2.60E-06 4.30E-04 dopamine metabolic process (GO:0042417) 31 6 .06 + > 100 1.86E-11 7.08E-09 secondary metabolite biosynthetic process (GO:0044550) 16 3 .03 + > 100 3.19E-06 5.18E-04 catecholamine metabolic process (GO:0006584) 49 9 .09 + 99.53 1.74E-16 2.04E-13 catechol-containing compound metabolic process (GO:0009712) 49 9 .09 + 99.53 1.74E-16 1.89E-13 2-oxoglutarate metabolic process (GO:0006103) 17 3 .03 + 95.63 3.87E-06 6.02E-04 response to corticosterone (GO:0051412) 17 3 .03 + 95.63 3.87E-06 5.96E-04 phenol-containing compound metabolic process (GO:0018958) 94 15 .17 + 86.47 3.43E-26 2.61E-22 retinoic acid metabolic process (GO:0042573) 32 5 .06 + 84.67 3.16E-09 7.90E-07 aspartate family amino acid catabolic process (GO:0009068) 13 2 .02 + 83.37 2.55E-04 2.80E-02 organic hydroxy compound catabolic process (GO:1901616) 59 9 .11 + 82.66 1.05E-15 7.27E-13 proteinogenic amino acid catabolic process (GO:0170040) 54 8 .10 + 80.28 5.99E-14 3.26E-11 aspartate family amino acid biosynthetic process (GO:0009067) 21 3 .04 + 77.41 7.54E-06 1.13E-03 primary amino compound metabolic process (GO:1901160) 14 2 .03 + 77.41 2.98E-04 3.19E-02 L-amino acid catabolic process (GO:0170035) 58 8 .11 + 74.74 1.10E-13 5.57E-11 biogenic amine biosynthetic process (GO:0042401) 38 5 .07 + 71.30 7.82E-09 1.83E-06 amine biosynthetic process (GO:0009309) 39 5 .07 + 69.47 8.95E-09 2.01E-06 glutamine family amino acid catabolic process (GO:0009065) 24 3 .04 + 67.74 1.14E-05 1.58E-03 anatomical structure regression (GO:0060033) 16 2 .03 + 67.74 3.91E-04 4.14E-02 synaptic transmission, dopaminergic (GO:0001963) 17 2 .03 + 63.75 4.43E-04 4.63E-02 cellular response to aldehyde (GO:0110096) 17 2 .03 + 63.75 4.43E-04 4.60E-02 thyroid hormone generation (GO:0006590) 17 2 .03 + 63.75 4.43E-04 4.56E-02 dicarboxylic acid catabolic process (GO:0043649) 17 2 .03 + 63.75 4.43E-04 4.53E-02 benzene-containing compound metabolic process (GO:0042537) 26 3 .05 + 62.53 1.46E-05 1.96E-03 retinol metabolic process (GO:0042572) 53 6 .10 + 61.35 5.63E-10 1.62E-07 alcohol catabolic process (GO:0046164) 36 4 .07 + 60.21 5.57E-07 1.05E-04 amine metabolic process (GO:0009308) 102 11 .19 + 58.44 2.72E-17 3.46E-14 biogenic amine metabolic process (GO:0006576) 93 10 .17 + 58.27 9.14E-16 6.97E-13 glutamate metabolic process (GO:0006536) 30 3 .06 + 54.19 2.27E-05 2.94E-03 primary alcohol metabolic process (GO:0034308) 96 9 .18 + 50.80 1.03E-13 5.43E-11 alpha-amino acid catabolic process (GO:1901606) 87 8 .16 + 49.83 3.22E-12 1.49E-09 response to amphetamine (GO:0001975) 33 3 .06 + 49.26 3.04E-05 3.90E-03 secondary metabolic process (GO:0019748) 47 4 .09 + 46.12 1.66E-06 2.98E-04 retinoid metabolic process (GO:0001523) 84 7 .16 + 45.16 1.66E-10 5.50E-08 diterpenoid metabolic process (GO:0016101) 89 7 .16 + 42.62 2.51E-10 7.96E-08 response to mineralocorticoid (GO:0051385) 40 3 .07 + 40.64 5.46E-05 6.83E-03 amino acid catabolic process (GO:0009063) 108 8 .20 + 40.14 1.89E-11 7.02E-09 cellular aldehyde metabolic process (GO:0006081) 69 5 .13 + 39.27 1.68E-07 3.37E-05 pigment biosynthetic process (GO:0046148) 42 3 .08 + 38.71 6.33E-05 7.85E-03 terpenoid metabolic process (GO:0006721) 100 7 .18 + 37.93 5.74E-10 1.62E-07 developmental pigmentation (GO:0048066) 43 3 .08 + 37.81 6.80E-05 8.36E-03 aspartate family amino acid metabolic process (GO:0009066) 46 3 .08 + 35.34 8.33E-05 1.01E-02 proteinogenic amino acid metabolic process (GO:0170039) 144 9 .27 + 33.87 4.26E-12 1.86E-09 response to amine (GO:0014075) 49 3 .09 + 33.18 1.01E-04 1.19E-02 isoprenoid metabolic process (GO:0006720) 135 8 .25 + 32.11 1.15E-10 4.07E-08 alpha-amino acid metabolic process (GO:1901605) 211 12 .39 + 30.82 2.10E-15 1.39E-12 L-amino acid metabolic process (GO:0170033) 159 9 .29 + 30.67 1.05E-11 4.43E-09 proteinogenic amino acid biosynthetic process (GO:0170038) 54 3 .10 + 30.11 1.35E-04 1.54E-02 L-amino acid biosynthetic process (GO:0170034) 54 3 .10 + 30.11 1.35E-04 1.53E-02 glutamine family amino acid metabolic process (GO:0009064) 72 4 .13 + 30.11 9.27E-06 1.37E-03 organic hydroxy compound biosynthetic process (GO:1901617) 174 9 .32 + 28.03 2.36E-11 8.55E-09 organic hydroxy compound metabolic process (GO:1901615) 494 25 .91 + 27.42 7.03E-32 1.07E-27 response to ethanol (GO:0045471) 125 6 .23 + 26.01 1.04E-07 2.15E-05 alpha-amino acid biosynthetic process (GO:1901607) 65 3 .12 + 25.01 2.34E-04 2.62E-02 pigment metabolic process (GO:0042440) 65 3 .12 + 25.01 2.34E-04 2.60E-02 dicarboxylic acid metabolic process (GO:0043648) 89 4 .16 + 24.35 2.15E-05 2.80E-03 amino acid biosynthetic process (GO:0008652) 67 3 .12 + 24.26 2.56E-04 2.79E-02 amino acid metabolic process (GO:0006520) 291 13 .54 + 24.21 2.71E-15 1.65E-12 cellular detoxification (GO:1990748) 114 5 .21 + 23.77 2.07E-06 3.62E-04 hormone metabolic process (GO:0042445) 208 9 .38 + 23.45 1.16E-10 4.03E-08 olefinic compound metabolic process (GO:0120254) 147 6 .27 + 22.12 2.73E-07 5.41E-05 cellular response to toxic substance (GO:0097237) 124 5 .23 + 21.85 3.13E-06 5.12E-04 pigmentation (GO:0043473) 106 4 .20 + 20.45 4.28E-05 5.44E-03 response to glucocorticoid (GO:0051384) 135 5 .25 + 20.07 4.74E-06 7.23E-04 response to toxic substance (GO:0009636) 243 9 .45 + 20.07 4.63E-10 1.36E-07 small molecule catabolic process (GO:0044282) 354 13 .65 + 19.90 3.38E-14 1.91E-11 detoxification (GO:0098754) 142 5 .26 + 19.08 6.07E-06 9.16E-04 organic acid catabolic process (GO:0016054) 232 8 .43 + 18.69 8.41E-09 1.94E-06 carboxylic acid catabolic process (GO:0046395) 232 8 .43 + 18.69 8.41E-09 1.91E-06 alcohol metabolic process (GO:0006066) 331 11 .61 + 18.01 1.28E-11 5.14E-09 response to corticosteroid (GO:0031960) 157 5 .29 + 17.26 9.90E-06 1.44E-03 carboxylic acid metabolic process (GO:0019752) 801 23 1.48 + 15.56 2.42E-23 1.23E-19 oxoacid metabolic process (GO:0043436) 823 23 1.52 + 15.14 4.49E-23 1.71E-19 organic acid metabolic process (GO:0006082) 830 23 1.53 + 15.02 5.44E-23 1.66E-19 response to alcohol (GO:0097305) 261 7 .48 + 14.53 4.38E-07 8.44E-05 generation of precursor metabolites and energy (GO:0006091) 412 11 .76 + 14.47 1.33E-10 4.52E-08 monocarboxylic acid metabolic process (GO:0032787) 528 14 .97 + 14.37 2.46E-13 1.17E-10 organic cyclic compound catabolic process (GO:1901361) 427 11 .79 + 13.96 1.95E-10 6.33E-08 aromatic compound catabolic process (GO:0019439) 399 10 .74 + 13.58 1.94E-09 5.20E-07 sphingolipid metabolic process (GO:0006665) 165 4 .30 + 13.14 2.37E-04 2.62E-02 cellular modified amino acid metabolic process (GO:0006575) 183 4 .34 + 11.84 3.52E-04 3.75E-02 fatty acid metabolic process (GO:0006631) 327 7 .60 + 11.60 1.97E-06 3.50E-04 cellular response to xenobiotic stimulus (GO:0071466) 194 4 .36 + 11.17 4.39E-04 4.61E-02 response to steroid hormone (GO:0048545) 284 5 .52 + 9.54 1.67E-04 1.88E-02 regulation of hormone levels (GO:0010817) 550 9 1.01 + 8.87 5.29E-07 1.01E-04 response to xenobiotic stimulus (GO:0009410) 434 7 .80 + 8.74 1.26E-05 1.72E-03 small molecule metabolic process (GO:0044281) 1640 26 3.03 + 8.59 2.36E-20 4.50E-17 response to light stimulus (GO:0009416) 318 5 .59 + 8.52 2.81E-04 3.04E-02 cellular lipid metabolic process (GO:0044255) 928 14 1.71 + 8.18 4.55E-10 1.36E-07 cellular catabolic process (GO:0044248) 1132 17 2.09 + 8.14 3.26E-12 1.46E-09 lipid metabolic process (GO:0006629) 1238 17 2.28 + 7.44 1.36E-11 5.30E-09 organonitrogen compound catabolic process (GO:1901565) 1126 14 2.08 + 6.74 5.54E-09 1.34E-06 organic substance catabolic process (GO:1901575) 1635 17 3.02 + 5.63 1.05E-09 2.90E-07 catabolic process (GO:0009056) 1938 18 3.58 + 5.03 1.65E-09 4.50E-07 aromatic compound biosynthetic process (GO:0019438) 1024 8 1.89 + 4.23 4.69E-04 4.77E-02 response to oxygen-containing compound (GO:1901700) 1554 12 2.87 + 4.18 1.39E-05 1.88E-03 cellular aromatic compound metabolic process (GO:0006725) 2971 21 5.48 + 3.83 4.92E-09 1.21E-06 organic cyclic compound metabolic process (GO:1901360) 3226 21 5.95 + 3.53 2.21E-08 4.74E-06 response to chemical (GO:0042221) 3780 23 6.98 + 3.30 9.61E-09 2.12E-06 response to organic substance (GO:0010033) 2467 14 4.55 + 3.08 7.07E-05 8.62E-03 cellular metabolic process (GO:0044237) 6416 36 11.84 + 3.04 1.88E-16 1.91E-13 organonitrogen compound metabolic process (GO:1901564) 4671 25 8.62 + 2.90 1.68E-08 3.66E-06 organic substance metabolic process (GO:0071704) 7437 37 13.72 + 2.70 1.01E-15 7.30E-13 metabolic process (GO:0008152) 7979 37 14.72 + 2.51 1.31E-14 7.69E-12 primary metabolic process (GO:0044238) 6944 28 12.81 + 2.19 7.11E-07 1.32E-04 nitrogen compound metabolic process (GO:0006807) 6426 25 11.86 + 2.11 1.26E-05 1.73E-03 cellular process (GO:0009987) 14948 38 27.58 + 1.38 9.45E-06 1.38E-03