Онтологии

Дано:

Белок: RSGA_BACSU | 1T9H

1. Описание функции белка RSGA_BACSU с помощью аннотации Gene Ontology.

	Онтология GO (название словаря)	Количество разных ассоциированных терминов GO	Функция белка (краткое описание, близкое к тексту определения термина(ов) GO
Где?
Зачем, для чего?	Process	1	GTP catabolic process
Молекулярный механизм?	Function	6	nucleotide binding GTPase activity GTP binding hydrolase activity metal ion binding
Специфичность?

2. Описание трёх терминов GO, ассоциированных с белком RSGA_BACSU

GO ID выбранного термина	Список синонимов	Список ближайших родительских терминов GO с указанием типа связи	Список ближайших дочерних терминов GO с указанием типа связи
GO:0003924	narrow: ARF small monomeric GTPase activity narrow: dynamin GTPase activity narrow: heterotrimeric G-protein GTPase activity related: heterotrimeric G-protein GTPase, alpha-subunit related: heterotrimeric G-protein GTPase, beta-subunit related: heterotrimeric G-protein GTPase, gamma-subunit broad: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement narrow: protein-synthesizing GTPase activity narrow: protein-synthesizing GTPase activity, elongation narrow: protein-synthesizing GTPase activity, initiation narrow: protein-synthesizing GTPase activity, termination narrow: Rab small monomeric GTPase activity narrow: Ran small monomeric GTPase activity narrow: Ras small monomeric GTPase activity narrow: RHEB small monomeric GTPase activity narrow: Rho small monomeric GTPase activity narrow: Sar small monomeric GTPase activity narrow: signal-recognition-particle GTPase activity narrow: small monomeric GTPase activity narrow: tubulin GTPase activity	is_a (inferred)molecular_function (GO:0003674) 480535 is_a (inferred) catalytic activity (GO:0003824) is_a (inferred) hydrolase activity (GO:0016787) is_a (inferred) hydrolase activity, acting on acid anhydrides (GO:0016817) is_a (inferred) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) is_a (inferred) pyrophosphatase activity (GO:0016462) is_a nucleoside-triphosphatase activity (GO:0017111)	GTP-dependent helicase activity (GO:0070036) is_a GTPase activity
GO:0000166	None	is_a (inferred) molecular_function (GO:0003674) is_a (inferred) binding (GO:0005488) is_a (inferred) organic cyclic compound binding (GO:0097159) is_a nucleoside phosphate binding (GO:1901265) is_a small molecule binding (GO:0036094)	ADP-D-ribose binding (GO:0072570) is_a nucleotide binding cyclic nucleotide binding (GO:0030551) is_a nucleotide binding deoxyribonucleotide binding (GO:0032552) is_a nucleotide binding FMN binding (GO:0010181) is_a nucleotide binding methyl-CpG binding (GO:0008327) is_a nucleotide binding methyl-CpNpG binding (GO:0010428) is_a nucleotide binding methyl-CpNpN binding (GO:0010429) is_a nucleotide binding NAD binding (GO:0051287) is_a nucleotide binding NADP binding (GO:0050661) is_a nucleotide binding purine nucleotide binding (GO:0017076) is_a nucleotide binding pyrimidine nucleotide binding (GO:0019103) is_a nucleotide binding ribonucleotide binding (GO:0032553) is_a nucleotide binding
GO:0003924	narrow: ARF small monomeric GTPase activity narrow: dynamin GTPase activity narrow: heterotrimeric G-protein GTPase activity related: heterotrimeric G-protein GTPase, alpha-subunit related: heterotrimeric G-protein GTPase, beta-subunit related: heterotrimeric G-protein GTPase, gamma-subunit broad: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement narrow: protein-synthesizing GTPase activity narrow: protein-synthesizing GTPase activity, elongation narrow: protein-synthesizing GTPase activity, initiation narrow: protein-synthesizing GTPase activity, termination narrow: Rab small monomeric GTPase activity narrow: Ran small monomeric GTPase activity narrow: Ras small monomeric GTPase activity narrow: RHEB small monomeric GTPase activity narrow: Rho small monomeric GTPase activity narrow: Sar small monomeric GTPase activity narrow: signal-recognition-particle GTPase activity narrow: small monomeric GTPase activity narrow: tubulin GTPase activity	is_a (inferred) molecular_function (GO:0003674) is_a (inferred) catalytic activity (GO:0003824) is_a (inferred) hydrolase activity (GO:0016787) GTPase activity is_a (inferred) hydrolase activity, acting on acid anhydrides (GO:0016817) GTPase activity is_a (inferred) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) is_a (inferred) pyrophosphatase activity (GO:0016462) is_a nucleoside-triphosphatase activity (GO:0017111)	GTP-dependent helicase activity (GO:0070036) is_a GTPase activity

3. Опишите протеом бактерии, полный геном которой секвенирован и аннотирован, используя термины GO. Бактерию выберите самостоятельно.

Выбранная бактерия: Nocardia farcinica
Число белков протеома: 5941 (SRS: 5965)
Процент белков, которым приписан хоть один термин GO: 59% (3521) (file)
Гистограмма (функция(F), процесс(P), локализация(C)) (script1):
Несколько самых часто встречающихся терминов из каждого словаря (script2):
F: GO:0003677(DNA binding) - 489, GO:0005524(ATP binding) - 430, GO:0016491(oxidoreductase activity) - 286
P: GO:0006351(transcription, DNA-dependent) - 277, GO:0006355(regulation of transcription) - 172, GO:0055114(oxidation-reduction process) - 128
C: GO:0016021(integral to membrane) - 328, GO:0005737(cytoplasm) - 257, GO:0005622(intracellular) - 201
Мои комментарии:
То что большАя часть белков имеет функцию ДНК-связывания, а также функции связанные с энергетическим обменом - совсем неудивительно. Процессы по сути напрямую связанные с функцией.

4. Получение выборки последовательностей белков с заданной функцией

Дано:

Hordeum

cellular amino acid biosynthetic process

GO:0008652

Ячмень (описание):

4512

Запрос:

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