RID: A2CTR2M2013 Job Title:AAD35292:conserved hypothetical protein [Thermotoga... Program: BLASTP Query: conserved hypothetical protein [Thermotoga maritima MSB8] ID: AAD35292.1(amino acid) Length: 357 Database: swissprot Non-redundant UniProtKB/SwissProt sequences Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=DNA integrity scanning protein DisA; AltName:... Thermotoga m... NA 243274 714 714 100% 0.0 100.00 357 Q9WY43.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Thermotoga n... NA 309803 667 667 98% 0.0 92.61 352 B9K6S9.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Thermotoga p... NA 390874 642 642 98% 0.0 96.31 352 A5IKM1.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 272562 288 288 96% 3e-94 44.70 357 Q97EC6.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Carboxydothe... NA 246194 287 287 96% 5e-94 46.55 352 Q3A9N3.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 431943 285 285 96% 2e-93 44.06 354 A5N4M2.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 935198 281 281 95% 9e-92 43.40 354 B2TIF1.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 212717 281 281 96% 2e-91 43.48 360 Q890L8.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 508767 279 279 95% 7e-91 43.11 354 B2UY85.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 498214 272 272 96% 3e-88 42.03 353 B1KTB1.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 441771 272 272 96% 3e-88 42.03 353 A5I7N4.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 536232 272 272 96% 4e-88 42.03 353 C1FNB1.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Hungateiclos... NA 203119 271 271 96% 6e-88 42.29 360 A3DGC7.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 515621 271 271 96% 8e-88 41.74 353 C3KVS9.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus pum... NA 315750 269 269 96% 8e-87 43.48 359 A8F956.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus sub... NA 224308 268 268 94% 2e-86 43.27 360 P37573.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Symbiobacter... NA 292459 265 265 94% 2e-85 43.36 351 Q67JP1.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 290402 265 265 94% 2e-85 41.00 354 A6LPN7.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus lic... NA 279010 264 264 97% 6e-85 42.29 358 Q65PD4.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 195102 263 263 98% 7e-85 42.74 354 Q8XHQ0.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridium ... NA 289380 263 263 98% 1e-84 42.45 354 Q0SQB6.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus myc... NA 315730 261 261 96% 6e-84 41.28 357 A9VN96.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus cer... NA 226900 261 261 96% 8e-84 41.28 357 Q81J64.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus cer... NA 405532 261 261 96% 1e-83 41.28 357 B7HJ22.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus cer... NA 405531 259 259 96% 4e-83 40.99 357 B7ISZ3.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus hal... NA 272558 256 256 94% 4e-82 39.47 357 Q9KGG0.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus thu... NA 412694 256 256 96% 5e-82 40.70 357 A0R8F5.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus cer... NA 405534 255 255 96% 2e-81 40.41 357 B7HQR7.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Frankia sp. ... NA 298653 254 254 93% 3e-81 42.90 359 A8LF79.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Clostridioid... NA 272563 254 254 96% 4e-81 40.69 356 Q18CB2.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Frankia alni... NA 326424 250 250 93% 1e-79 42.31 359 Q0RBN2.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Bacillus cla... NA 66692 249 249 94% 2e-79 38.89 357 Q5WLT9.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Frankia casu... NA 106370 245 245 93% 1e-77 42.01 359 Q2J537.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Kineococcus ... NA 266940 239 239 96% 4e-75 40.11 359 A6W5K2.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Streptomyces... NA 100226 237 237 94% 2e-74 41.33 374 Q9X8L6.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Acidothermus... NA 351607 237 237 95% 2e-74 41.95 368 A0LRE3.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Streptomyces... NA 227882 235 235 94% 1e-73 41.11 374 Q82EA6.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Streptomyces... NA 455632 226 226 94% 4e-70 39.83 374 B1VSK3.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Mycobacteriu... NA 419947 225 225 97% 8e-70 39.38 358 A5U8R1.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Mycobacteriu... NA 410289 224 224 97% 3e-69 39.09 358 A1KPS2.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Mycobacteriu... NA 262316 222 222 95% 8e-69 40.17 357 Q743W9.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Beutenbergia... NA 471853 221 221 94% 2e-68 39.41 359 C5C1B3.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Mycobacteriu... NA 243243 221 221 95% 3e-68 40.17 357 A0QAA9.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Fusobacteriu... NA 190304 218 218 96% 4e-67 36.89 349 Q8RGW9.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Mycolicibact... NA 246196 218 218 95% 1e-66 39.27 372 A0R564.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Corynebacter... NA 196627 211 211 94% 2e-64 37.50 366 Q8NMB2.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Corynebacter... NA 340322 210 210 94% 5e-64 37.50 366 A4QH66.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Corynebacter... NA 196164 210 210 94% 6e-64 37.61 356 Q8FMH9.1 RecName: Full=DNA integrity scanning protein DisA; AltName:... Cutibacteriu... NA 267747 178 178 94% 6e-52 34.62 344 Q6AAZ9.1 RecName: Full=UvrABC system protein C; Short=Protein UvrC;... Lawsonia int... NA 363253 42.4 42.4 16% 0.005 35.48 621 Q1MQH2.1 RecName: Full=UvrABC system protein C; Short=Protein UvrC;... Thermoanaero... NA 340099 42.4 42.4 8% 0.005 61.29 615 B0K791.1 RecName: Full=UvrABC system protein C; Short=Protein UvrC;... Thermoanaero... NA 399726 42.4 42.4 8% 0.005 61.29 615 B0K680.1 RecName: Full=DNA ligase; AltName: Full=Polydeoxyribonucleotid... Thermobifida... NA 269800 40.8 40.8 13% 0.014 43.75 745 Q47SC6.1 RecName: Full=DNA ligase; AltName: Full=Polydeoxyribonucleotid... Chlamydia pn... NA 83558 40.4 40.4 21% 0.021 35.53 662 Q9Z934.1 Alignments: >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Thermotoga maritima MSB8] Sequence ID: Q9WY43.1 Length: 357 Range 1: 1 to 357 Score:714 bits(1842), Expect:0.0, Method:Compositional matrix adjust., Identities:357/357(100%), Positives:357/357(100%), Gaps:0/357(0%) Query 1 MGVKSLVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLD 60 MGVKSLVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLD Sbjct 1 MGVKSLVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLD 60 Query 61 TDFSAEKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTG 120 TDFSAEKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTG Sbjct 61 TDFSAEKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTG 120 Query 121 KVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLEL 180 KVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLEL Sbjct 121 KVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLEL 180 Query 181 ENRVTLADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIM 240 ENRVTLADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIM Sbjct 181 ENRVTLADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIM 240 Query 241 DYSSEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTV 300 DYSSEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTV Sbjct 241 DYSSEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTV 300 Query 301 ARIPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 ARIPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE Sbjct 301 ARIPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Thermotoga neapolitana DSM 4359] Sequence ID: B9K6S9.1 Length: 352 Range 1: 1 to 352 Score:667 bits(1721), Expect:0.0, Method:Compositional matrix adjust., Identities:326/352(93%), Positives:345/352(98%), Gaps:0/352(0%) Query 6 LVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSA 65 +VPQELIEKIKLISPGTELRKALDDII+ANFGALIFLVDDPKKY+D+IQGGFWLDTDFSA Sbjct 1 MVPQELIEKIKLISPGTELRKALDDIISANFGALIFLVDDPKKYDDIIQGGFWLDTDFSA 60 Query 66 EKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA 125 EK+YELSKMDGAIVLSED+T+IYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA Sbjct 61 EKVYELSKMDGAIVLSEDLTRIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA 120 Query 126 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVT 185 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNF+KLLS+LEVLELENRVT Sbjct 121 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFDKLLSDLEVLELENRVT 180 Query 186 LADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSE 245 LADVVRTL KG ELLRI EE RPYIVELGEEGRLARMQLRELTEDVDDL+VLLIMDYSS+ Sbjct 181 LADVVRTLMKGVELLRITEETRPYIVELGEEGRLARMQLRELTEDVDDLMVLLIMDYSSD 240 Query 246 EVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPL 305 EV+EETAQ ILQDF+TRREPSPISISRVLGYDVQQ +QLDD+LVSARGYRLLKT ARIP+ Sbjct 241 EVDEETAQAILQDFVTRREPSPISISRVLGYDVQQVSQLDDILVSARGYRLLKTAARIPI 300 Query 306 SIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 SIGYNVV+MFKTLDQISKASVEDLKKVEGIGEKRA+AISESISSLKHR+TSE Sbjct 301 SIGYNVVKMFKTLDQISKASVEDLKKVEGIGEKRAKAISESISSLKHRRTSE 352 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Thermotoga petrophila RKU-1] Sequence ID: A5IKM1.1 Length: 352 Range 1: 1 to 352 Score:642 bits(1656), Expect:0.0, Method:Compositional matrix adjust., Identities:339/352(96%), Positives:348/352(98%), Gaps:0/352(0%) Query 6 LVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSA 65 +VPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYED+IQGGFWLDTDFSA Sbjct 1 MVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDIIQGGFWLDTDFSA 60 Query 66 EKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA 125 EKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA Sbjct 61 EKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA 120 Query 126 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVT 185 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVT Sbjct 121 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVT 180 Query 186 LADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSE 245 LADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLL+MDYSSE Sbjct 181 LADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLVMDYSSE 240 Query 246 EVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPL 305 EV+EE AQ+I+QDF+ +R+PSPISISR LGYDVQQ AQLDDVLVSARGYRLLKTVARIPL Sbjct 241 EVDEEAAQDIMQDFVKKRDPSPISISRALGYDVQQVAQLDDVLVSARGYRLLKTVARIPL 300 Query 306 SIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 SIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE Sbjct 301 SIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 352 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium acetobutylicum ATCC 824] Sequence ID: Q97EC6.1 Length: 357 Range 1: 10 to 350 Score:288 bits(736), Expect:3e-94, Method:Compositional matrix adjust., Identities:156/349(45%), Positives:230/349(65%), Gaps:12/349(3%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQ---GGFWLDTDFSA 65 ++L+E +K ++PGT++R+ L++I+ A G L+ L D+ E+V++ GGF +++++SA Sbjct 10 RKLLEILKTMAPGTDMREGLENILRAKTGGLVVLGDN----EEVMKLSDGGFKINSEYSA 65 Query 66 EKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA 125 +YEL+KMDGAI+LS D+ KI ANV LVPD +IPT ETGTRHRTA R+AKQTG VV+A Sbjct 66 SYIYELAKMDGAIILSSDLKKIVRANVQLVPDSSIPTFETGTRHRTAHRVAKQTGNVVVA 125 Query 126 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVT 185 +S+RRN+I++Y + KY++ ++++ QAI TLEKY ++++ L +LE E+ T Sbjct 126 ISQRRNVITIYKDDIKYILRDSSIILARANQAIQTLEKYVAVLDRVMGNLNLLEFEDLCT 185 Query 186 LADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSE 245 L DVV + + ++R+V EI YI ELG EGRL MQL EL ++V+ +L+I DY Sbjct 186 LHDVVAAIQRTEMVMRVVTEIDRYICELGNEGRLISMQLNELVKNVEQDGMLIIRDYCQN 245 Query 246 EVEEETAQNILQDFITRREPSPISISRVLGY-DVQQAAQLDDVLVSARGYRLLKTVARIP 304 E+ +Q + + +IS+V+GY DV L D L+S RGYR+ + RIP Sbjct 246 EMNYSKVCETIQSMSSEEFLNSEAISKVMGYGDV----PLIDTLISPRGYRMTSKIPRIP 301 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 + N+V+ FK L +I +AS EDL KVEGIGE RARAI + LK + Sbjct 302 FIVIENLVKNFKELKKILEASHEDLDKVEGIGEARARAIKSGLRKLKEQ 350 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Carboxydothermus hydrogenoformans Z-2901] Sequence ID: Q3A9N3.1 Length: 352 Range 1: 4 to 347 Score:287 bits(734), Expect:5e-94, Method:Compositional matrix adjust., Identities:162/348(47%), Positives:227/348(65%), Gaps:7/348(2%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + ++ +K ++PGT LR+ L+ I+ A G LI ++ D K +V++GGF ++TD+S L Sbjct 4 ERIVLALKSVAPGTPLREGLEQILRAKTGGLI-VIGDTAKIMEVVEGGFAINTDYSPAYL 62 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGAI+LSED KI YAN LVPDP IP+ ETG RHRTAER+AKQT +VIA+S+ Sbjct 63 YELAKMDGAIILSEDGKKILYANAQLVPDPAIPSSETGIRHRTAERVAKQTNALVIAISQ 122 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RR++I+LY N+KY +++V +++K QAI+TLEKY+ +K L L LE ++ VTL D Sbjct 123 RRSVITLYQGNFKYSLSEVSVILNKANQAIATLEKYRAVLDKTLMRLTNLEFDDMVTLLD 182 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 V + L + +LRI EI YI ELG EGRL MQL EL +V+D +L+I DYS Sbjct 183 VAKALQRVEMVLRIEREIERYIWELGSEGRLISMQLEELIANVEDEGLLIIQDYSLLG-P 241 Query 249 EETAQNILQDFITRREPSPISIS---RVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPL 305 E+T + IL T + S R LGY +A + D VS RGYR+L + R+P+ Sbjct 242 EKTPEGILSLIRTWSSEDLLDYSLIVRALGY--PGSASILDQPVSPRGYRILDKIPRLPV 299 Query 306 SIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 ++ N+V+ F L I AS+E+L VEGIGE RAR+I E + L+ + Sbjct 300 AVIENLVQTFGNLKNIMSASIEELDDVEGIGEVRARSIKEGLKKLREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium kluyveri DSM 555] Sequence ID: A5N4M2.1 Length: 354 Range 1: 7 to 347 Score:285 bits(730), Expect:2e-93, Method:Compositional matrix adjust., Identities:152/345(44%), Positives:227/345(65%), Gaps:4/345(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 +EL +KL++PGT+LR+ L++I+ A G LI L D ++ V+ GGF +++++S + Sbjct 7 KELKSILKLLAPGTQLREGLENILRAKTGGLIVL-GDSEQILKVVDGGFAINSEYSPSYI 65 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGAI+LS D+ KI YAN L+PD TIPT ETGTRHRTA+R+AKQTG +VIA+S+ Sbjct 66 YELAKMDGAIILSSDLKKILYANTQLIPDSTIPTFETGTRHRTADRVAKQTGVIVIAISQ 125 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I++Y + KYV+ ++ + QA+ TLEKY +++++ L +LE ++ VTL D Sbjct 126 RRNVITVYRGHIKYVLRDSSVMLGRANQALQTLEKYVAVLDRVVNNLNILEFQDIVTLFD 185 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 V+ + + ++RIV EI YI ELG EGRL MQL EL + V+ + +I DY +++ Sbjct 186 VMTAIQRTEMVMRIVSEIEIYICELGNEGRLISMQLNELIKSVERDGIFMIRDYCQTDMD 245 Query 249 EETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIG 308 + +Q+ + + ISR +GY L D L+S RGYR+L + RIP ++ Sbjct 246 YDEIYRQIQEISSDDVLNLDFISRAMGY---VGVPLVDTLISPRGYRMLSKIPRIPATVM 302 Query 309 YNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 N+V+ FK L +I +AS EDL +VEGIGE RARAI + L+ + Sbjct 303 DNLVKNFKELKEIMEASYEDLDRVEGIGEARARAIKNGLRRLREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum B str. Eklund 17B (NRP)] Sequence ID: B2TIF1.1 Length: 354 Range 1: 11 to 347 Score:281 bits(719), Expect:9e-92, Method:Compositional matrix adjust., Identities:148/341(43%), Positives:223/341(65%), Gaps:4/341(1%) Query 13 EKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELS 72 + +K++ PGT+LR+ L++I+ A G LI ++ D K+ D + GGF L++D+S +YEL+ Sbjct 11 DTLKIMCPGTQLREGLENILRAKTGGLI-VIGDNKEVMDTVDGGFNLNSDYSPSYVYELA 69 Query 73 KMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNI 132 KMDGAIV+SED+ KI AN L+PDP+I T ETGTRHRTA R+AKQT +VIA+S+RRNI Sbjct 70 KMDGAIVISEDLKKIVCANAQLIPDPSIVTHETGTRHRTAHRIAKQTNNIVIAISQRRNI 129 Query 133 ISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRT 192 I++Y + KYV+ ++++ QAI TLEKY ++++ L +LE ++ TL DVV Sbjct 130 ITVYKGDIKYVLRDSSVILARANQAIQTLEKYVSVLERVINNLNLLEFQDLTTLFDVVTA 189 Query 193 LAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETA 252 + + ++RIVEEI YI+ELG EGRL MQL EL + ++ +LLI DY +E Sbjct 190 IQRTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKDEDGHNEV 249 Query 253 QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVV 312 +Q +I+RVLG+ L D L+SA+GYR+L V RIP ++ N++ Sbjct 250 YEQIQKLSATELLDLDAIARVLGH---AGESLVDTLISAKGYRILGKVPRIPSTVIENLI 306 Query 313 RMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 + FK L+ + +A +++L VEGIGE RA+AI + + ++ + Sbjct 307 KEFKELNSVIEADIDELDIVEGIGEARAKAIKDGLKRIREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium tetani E88] Sequence ID: Q890L8.1 Length: 360 Range 1: 10 to 350 Score:281 bits(718), Expect:2e-91, Method:Compositional matrix adjust., Identities:150/345(43%), Positives:221/345(64%), Gaps:4/345(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 +L++ + +++PGT LR L++I+ A G LI ++ D ++ D++ GGF +D ++S + Sbjct 10 NDLMDILNIMAPGTPLRDGLENILRAKTGGLI-VIGDSEEILDIVDGGFTIDAEYSPSYV 68 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGAI+LS D+ +I AN L+PDP++PT ETGTRHRTA+R+AKQTG +VIA+S+ Sbjct 69 YELAKMDGAIILSGDVKRIIRANAQLMPDPSVPTFETGTRHRTADRIAKQTGNIVIAISQ 128 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRNII++Y N KYV+ ++ K QA+ TLEKY +K+++ L VLE + VTL D Sbjct 129 RRNIITIYRNNIKYVLRDSSVILGKANQALQTLEKYVSVLDKVINNLNVLEFRDLVTLFD 188 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 V+ + + ++RIV E+ YI ELG E RL MQL EL V++ +LLI DY ++ Sbjct 189 VMTAIQRTEMVMRIVWEMERYICELGNEARLISMQLNELVRYVEEDEILLIRDYCETYMD 248 Query 249 EETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIG 308 + +Q + + IS++LGY L D +S RGYR+L + RIP ++ Sbjct 249 YTEVYDEIQSMSSEELINLDQISKILGY---TGVPLVDTFISPRGYRMLHRIPRIPSNVI 305 Query 309 YNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 NVV+ FK L + +AS E L KVEGIGE RA+AI + LK + Sbjct 306 ENVVKNFKELKAVMEASYEQLDKVEGIGEARAKAIKNGLRRLKEQ 350 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum E3 str. Alaska E43] Sequence ID: B2UY85.1 Length: 354 Range 1: 11 to 347 Score:279 bits(713), Expect:7e-91, Method:Compositional matrix adjust., Identities:147/341(43%), Positives:224/341(65%), Gaps:4/341(1%) Query 13 EKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELS 72 + +K++ PGT+LR+ L++I+ A G LI ++ D K+ D + GGF L++D+S +YEL+ Sbjct 11 DTLKIMCPGTQLREGLENILRAKTGGLI-VIGDNKEVMDTVDGGFTLNSDYSPSYVYELA 69 Query 73 KMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNI 132 KMDGAIV+SED+ KI AN L+PDP+I T ETGTRHRTA R+AKQT +VIA+S+RRNI Sbjct 70 KMDGAIVISEDLKKIVCANAQLIPDPSIITHETGTRHRTAHRIAKQTNNIVIAISQRRNI 129 Query 133 ISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRT 192 I++Y + KYV+ ++++ QAI TLEKY ++++ L +LE ++ TL DVV Sbjct 130 ITVYKGDIKYVLRDSSVILARANQAIQTLEKYVSVLERVINNLNLLEFQDLTTLFDVVTA 189 Query 193 LAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETA 252 + + ++RIVEEI YI+ELG EGRL MQL EL + ++ +LLI DY E+ E Sbjct 190 IQRTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKEDFEYNEV 249 Query 253 QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVV 312 +Q +I+R+LG+ L D L+SA+GYR+L V RIP ++ N++ Sbjct 250 YEQIQKLSAAELLDLDAIARLLGH---TGDPLVDTLISAKGYRILGKVPRIPSTVIENLI 306 Query 313 RMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 + F+ L+ + +A +++L VEGIGE RA+AI + + ++ + Sbjct 307 KEFRELNSVIEADLDELDIVEGIGEARAKAIKDGLKRIREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum A3 str. Loch Maree] Sequence ID: B1KTB1.1 Length: 353 Range 1: 7 to 347 Score:272 bits(696), Expect:3e-88, Method:Compositional matrix adjust., Identities:145/345(42%), Positives:220/345(63%), Gaps:4/345(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 +EL+ +K+++PGT LR+ L++I+ A G L+ L D + ++ GGF +++++S + Sbjct 7 KELMNILKIMAPGTPLREGLENILRAKTGGLLIL-GDSDQILKLVDGGFKINSEYSPSYV 65 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDG+IVLS D+ KI AN L+PD +IPT ETGTRHRTA+R+AKQTG +VIA+S+ Sbjct 66 YELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGSIVIAISQ 125 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRNII++Y KYV+ ++++ QA+ TLEKY +++++ L +LE ++ TL D Sbjct 126 RRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFD 185 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV + + ++RIV EI YI ELG EGRL MQL EL + V++ +LLI DY +E Sbjct 186 VVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNME 245 Query 249 EETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIG 308 E +Q + + +S+++GY L D L+S RGYR++ + RIP ++ Sbjct 246 YEDIYKQIQGLSSEELLNLDGLSKIIGY---TGVPLVDTLISPRGYRMINKIPRIPSNVI 302 Query 309 YNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 N+V F L + +AS E L VEGIGE RA+AI + L+ + Sbjct 303 ENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum A str. Hall] Sequence ID: A5I7N4.1 Length: 353 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum A str. ATCC 19397] Sequence ID: A7FZ95.1 Length: 353 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum F str. Langeland] Sequence ID: A7GJA2.1 Length: 353 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum B1 str. Okra] Sequence ID: B1IGI2.1 Length: 353 Range 1: 7 to 347 Score:272 bits(695), Expect:3e-88, Method:Compositional matrix adjust., Identities:145/345(42%), Positives:220/345(63%), Gaps:4/345(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 +EL+ +K+++PGT LR+ L++I+ A G L+ L D + ++ GGF +++++S + Sbjct 7 KELMNILKIMAPGTPLREGLENILRAKTGGLLIL-GDSDQILKLVDGGFKINSEYSPSYV 65 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDG+IVLS D+ KI AN L+PD +IPT ETGTRHRTA+R+AKQTG +VIA+S+ Sbjct 66 YELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQ 125 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRNII++Y KYV+ ++++ QA+ TLEKY +++++ L +LE ++ TL D Sbjct 126 RRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFD 185 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV + + ++RIV EI YI ELG EGRL MQL EL + V++ +LLI DY +E Sbjct 186 VVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNME 245 Query 249 EETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIG 308 E +Q + + +S+++GY L D L+S RGYR++ + RIP ++ Sbjct 246 YEDIYKQIQGLSSEELLNLDGLSKIIGY---TGVPLVDTLISPRGYRMINKIPRIPSNVI 302 Query 309 YNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 N+V F L + +AS E L VEGIGE RA+AI + L+ + Sbjct 303 ENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum A2 str. Kyoto] Sequence ID: C1FNB1.1 Length: 353 Range 1: 7 to 347 Score:272 bits(695), Expect:4e-88, Method:Compositional matrix adjust., Identities:145/345(42%), Positives:220/345(63%), Gaps:4/345(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 +EL+ +K+++PGT LR+ L++I+ A G L+ L D + ++ GGF +++++S + Sbjct 7 KELMNILKIMAPGTPLREGLENILRAKTGGLLIL-GDSDQILKLVDGGFKINSEYSPSYV 65 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDG+IVLS D+ KI AN L+PD +IPT ETGTRHRTA+R+AKQTG +VIA+S+ Sbjct 66 YELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQ 125 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRNII++Y KYV+ ++++ QA+ TLEKY +++++ L +LE ++ TL D Sbjct 126 RRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFD 185 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV + + ++RIV EI YI ELG EGRL MQL EL + V++ +LLI DY +E Sbjct 186 VVTAVQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNME 245 Query 249 EETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIG 308 E +Q + + +S+++GY L D L+S RGYR++ + RIP ++ Sbjct 246 YEDIYKQIQGLSSEELLNLDGLSKIIGY---TGVPLVDTLISPRGYRMINKIPRIPSNVI 302 Query 309 YNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 N+V F L + +AS E L VEGIGE RA+AI + L+ + Sbjct 303 ENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Hungateiclostridium thermocellum ATCC 27405] Sequence ID: A3DGC7.1 Length: 360 Range 1: 11 to 352 Score:271 bits(694), Expect:6e-88, Method:Compositional matrix adjust., Identities:148/350(42%), Positives:232/350(66%), Gaps:14/350(4%) Query 10 ELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLY 69 E+IE +++++PGT LR+ LD+I+ A GALI ++ D +K ++ GGF+++ D++ +Y Sbjct 11 EIIEVLRMMAPGTSLREGLDNILLARTGALI-VIGDSEKVLSLVDGGFYINKDYTPAHIY 69 Query 70 ELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRR 129 EL+KMDGAI+LS+D+ KI YAN LVPD +IPT ETGTRH+TA+R+AKQTG+VV+++S+R Sbjct 70 ELAKMDGAIILSKDLKKILYANALLVPDTSIPTAETGTRHKTADRVAKQTGEVVVSISQR 129 Query 130 RNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADV 189 RNII++Y + KY++ + ++++ QA+ TLEKYK + ++ L +LE+E+ VTL DV Sbjct 130 RNIITIYMGSRKYILRETPVILAEANQALQTLEKYKVALVEAINNLNILEIEDIVTLDDV 189 Query 190 VRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYS------ 243 L + L+R+ EI YI ELG EGRL +QL EL +VD + +I DY+ Sbjct 190 AFVLQRTEMLMRVAAEIERYISELGSEGRLISLQLDELLTNVDADELFIIEDYAIRTDLR 249 Query 244 SEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARI 303 S+E+ E+ Q + + + ++I +LGY A ++++S RGYRLL + R+ Sbjct 250 SDEILEKLRQLSYDELM-----NLVNICSILGY--SPNADAFEMVISPRGYRLLSKIPRV 302 Query 304 PLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 P++I N+V+ F L I AS+E+L V GIGE RAR I + + ++ + Sbjct 303 PVNIIRNLVKKFSNLQGILNASIEELDDVAGIGEVRARIIWDGLRRVQEQ 352 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium botulinum Ba4 str. 657] Sequence ID: C3KVS9.1 Length: 353 Range 1: 7 to 347 Score:271 bits(693), Expect:8e-88, Method:Compositional matrix adjust., Identities:144/345(42%), Positives:220/345(63%), Gaps:4/345(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 +EL+ +K+++PGT LR+ L++I+ A G L+ L D + ++ GGF +++++S + Sbjct 7 KELMNILKIMAPGTPLREGLENILRAKTGGLLIL-GDSDQILKLVDGGFKINSEYSPSYV 65 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDG+IVLS D+ KI AN L+PD +IPT ETGTRHRTA+R+AKQTG +VIA+S+ Sbjct 66 YELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQ 125 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRNII++Y KYV+ ++++ QA+ TLEKY +++++ L +LE ++ TL D Sbjct 126 RRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFD 185 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 V+ + + ++RIV EI YI ELG EGRL MQL EL + V++ +LLI DY +E Sbjct 186 VLTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNME 245 Query 249 EETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIG 308 E +Q + + +S+++GY L D L+S RGYR++ + RIP ++ Sbjct 246 YEDIYKQIQGLSSEELLNLDGLSKIIGY---TGVPLVDTLISPRGYRMINKIPRIPSNVI 302 Query 309 YNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 N+V F L + +AS E L VEGIGE RA+AI + L+ + Sbjct 303 ENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus pumilus SAFR-032] Sequence ID: A8F956.1 Length: 359 Range 1: 12 to 352 Score:269 bits(687), Expect:8e-87, Method:Compositional matrix adjust., Identities:150/345(43%), Positives:215/345(62%), Gaps:5/345(1%) Query 10 ELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLY 69 +L++ ++ ++PGT LR +++++ AN G LI +V K + V+ GGF +++ FS LY Sbjct 12 DLLDIVQFVAPGTPLRAGIENVLRANTGGLI-VVGYNDKVKSVVDGGFHINSAFSPAHLY 70 Query 70 ELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRR 129 EL+KMDGAI+LS+ KI YAN L+PD TI + ETG RHRTAER+AKQTG ++IA+S R Sbjct 71 ELAKMDGAIILSDSGQKILYANTQLMPDATIHSSETGMRHRTAERVAKQTGCLIIAISER 130 Query 130 RNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADV 189 RN+I+LY N +Y + + F+++K QAI TLEKYK + +S L LE E VT DV Sbjct 131 RNVITLYQGNRRYTLKDIGFILTKANQAIQTLEKYKTILDHAISALSALEFEELVTFGDV 190 Query 190 VRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEE 249 + L + +LRI EI YI ELG EG L R+Q+ EL D++ L I DY E++++ Sbjct 191 LSVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVNELITDMEQEAALFIKDYVKEKIKD 250 Query 250 E-TAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIG 308 LQD + + ++LGY A+ D V RGYRLL + R+P+ I Sbjct 251 PYVLLKQLQDMSSFELLDDSILYKLLGY---PASTNIDEYVYTRGYRLLHKIPRLPMPIV 307 Query 309 YNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 NVV F LD+I +A V+DL +VEGIGE RA+ I + + L+ + Sbjct 308 ENVVEAFGVLDRIMEADVQDLDEVEGIGEVRAKKIKKGLKRLQEK 352 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase; Short=DAC [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P37573.1 Length: 360 Range 1: 18 to 353 Score:268 bits(685), Expect:2e-86, Method:Compositional matrix adjust., Identities:151/349(43%), Positives:219/349(62%), Gaps:23/349(6%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 ++ ++PGT LR +++++ AN G LI +V K ++V+ GGF ++T FS LYEL+KM Sbjct 18 LQFVAPGTPLRAGMENVLRANTGGLI-VVGYNDKVKEVVDGGFHINTAFSPAHLYELAKM 76 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGAI+LS+ KI YAN L+PD TI + ETG RHRTAER+AKQTG +VIA+S RRN+I+ Sbjct 77 DGAIILSDSGQKILYANTQLMPDATISSSETGMRHRTAERVAKQTGCLVIAISERRNVIT 136 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 LY +N KY + + F+++K QAI TLEKYK +K ++ L LE E VT +DV+ + Sbjct 137 LYQENMKYTLKDIGFILTKANQAIQTLEKYKTILDKTINALNALEFEELVTFSDVLSVMH 196 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSE--------- 245 + +LRI EI YI ELG EG L ++Q+ EL D+++ L I DY E Sbjct 197 RYEMVLRIKNEINMYIKELGTEGHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLL 256 Query 246 -EVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIP 304 E+++ ++ ++L D I + ++LGY + LDD V RGYRLL + R+P Sbjct 257 KELQDMSSYDLLDDSI---------VYKLLGYPA--STNLDDY-VLPRGYRLLNKIPRLP 304 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 + I NVV F L +I +AS E+L +VEGIGE RA+ I + + L+ + Sbjct 305 MPIVENVVEAFGVLPRIIEASAEELDEVEGIGEVRAQKIKKGLKRLQEK 353 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Symbiobacterium thermophilum IAM 14863] Sequence ID: Q67JP1.1 Length: 351 Range 1: 11 to 342 Score:265 bits(677), Expect:2e-85, Method:Compositional matrix adjust., Identities:147/339(43%), Positives:220/339(64%), Gaps:9/339(2%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 ++ ++PGT LR+ L+ I+ A G+LI + D P+ ++ GGF LD +F+ +LYEL+KM Sbjct 11 LQQLAPGTALREGLESILLARTGSLIVVGDSPEVLA-LVDGGFRLDCEFTPTRLYELAKM 69 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGAI+L+ D +I YAN LVPDP+IPT ETGTRHRTAER+A+QTG++VI++S+RR++I+ Sbjct 70 DGAIILTRDAQRILYANAMLVPDPSIPTSETGTRHRTAERVARQTGELVISISQRRDLIT 129 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 LY KY++ +++K QA+ TLEKYK ++ ++ L LEL++ V+ DV + Sbjct 130 LYKGPMKYILRDFAVVLTKANQALQTLEKYKLVRDQAVARLSALELDDMVSALDVALVVQ 189 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETA-- 252 + LLRI +EI YIVELG EGRL MQL EL V +L+I DY+S + + A Sbjct 190 RTEMLLRIGKEIERYIVELGTEGRLVAMQLEELLAGVAAEGLLIIRDYASTDDPQHAAAL 249 Query 253 QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVV 312 + + ++ +++R+LG A LD L ARGYR+L+ + R+P ++ N+V Sbjct 250 RQQMAEWTYEELQDLAAVARLLG-----AGALDSPL-GARGYRMLRRIPRLPAAVIENLV 303 Query 313 RMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 F L ++ AS+E+L VEGIGE RARAI E + ++ Sbjct 304 ARFGRLQRVLAASLEELDDVEGIGEVRARAIQEGLRRMR 342 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium beijerinckii NCIMB 8052] Sequence ID: A6LPN7.1 Length: 354 Range 1: 13 to 347 Score:265 bits(676), Expect:2e-85, Method:Compositional matrix adjust., Identities:139/339(41%), Positives:217/339(64%), Gaps:4/339(1%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 +K++ PGT+LR+ L++I+ A G L+ + DD + + ++ GGF+++++++ YEL+KM Sbjct 13 LKIMCPGTQLREGLENILRAKTGGLLVIGDDEEVMK-LVDGGFYINSEYTPSYAYELAKM 71 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGAIV++ D+ KI AN L+PD +IPT ETGTRHRTA R+AKQT +VIA+S+RRNII+ Sbjct 72 DGAIVITGDLKKIVCANAQLIPDSSIPTYETGTRHRTAHRVAKQTNNIVIAISQRRNIIT 131 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 +Y + KYV+ + ++ K QA+ TLEKY ++++ L +LE ++ TL DVV + Sbjct 132 MYKGDIKYVLRESSVILGKANQALQTLEKYVAVLERVINNLNLLEFQDLTTLFDVVTAIQ 191 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQN 254 + ++RIVEEI YI+ELG EGRL MQL EL + ++ +LLI DY + ++ Sbjct 192 RTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKDGLQYNEVYE 251 Query 255 ILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVVRM 314 +Q + +++R LG + L D L+S +GYR+L V RIP ++ N+++ Sbjct 252 HIQKLNSSELLELDAVARTLG---RGGIPLMDTLISPKGYRMLSKVPRIPSNVIDNLIKE 308 Query 315 FKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 F+ L I A + DL VEGIGE RA AI + + +K + Sbjct 309 FEELSNIIDADINDLDNVEGIGEARATAIKDGLKRIKEQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus licheniformis DSM 13 = ATCC 14580] Sequence ID: Q65PD4.1 Length: 358 Range 1: 10 to 355 Score:264 bits(674), Expect:6e-85, Method:Compositional matrix adjust., Identities:148/350(42%), Positives:217/350(62%), Gaps:5/350(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 Q+L E ++ ++PGT LR+ +++++ A G LI +V K ++V+ GGF +++ FS L Sbjct 10 QDLSEILQFVAPGTPLREGIENVLRAKTGGLI-VVGFNDKVKEVVDGGFHINSSFSPAHL 68 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGAI+LS+ KI YAN L+P+ TIP+ ETG RHRTAER+AKQTG ++IA+S Sbjct 69 YELAKMDGAIILSDSGQKILYANTQLMPEATIPSSETGMRHRTAERVAKQTGCLIIAISE 128 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I+LY +N KY++ + F+++K QAI TLEKYK + +S L LE E VT D Sbjct 129 RRNVITLYQENMKYILKDIGFILTKANQAIQTLEKYKLILDHAISNLNALEFEELVTFGD 188 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 V+ L + +LRI EI YI ELG EG L R+Q+ EL D++ L + DY E+++ Sbjct 189 VISVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVSELITDMEQEAALFVKDYVKEKIK 248 Query 249 EE-TAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 + LQD + + ++LGY A + V RGYRLL + R+P+ I Sbjct 249 DPFVLLKQLQDMSSFELLDDAILLKLLGY---SATTNMEEYVFPRGYRLLHKIPRLPMPI 305 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 NVV F L I +A V+DL +VEGIG RA+ I + + L+ + ++ Sbjct 306 VENVVEAFGHLKLIIEADVKDLDEVEGIGAVRAQKIKKGLKRLQEKHYTD 355 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium perfringens str. 13] Sequence ID: Q8XHQ0.1 Length: 354 Range 1: 1 to 347 Score:263 bits(673), Expect:7e-85, Method:Compositional matrix adjust., Identities:150/351(43%), Positives:221/351(62%), Gaps:4/351(1%) Query 3 VKSLVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTD 62 ++++ EL + +K++SPGT LR+ LD+I+ A G LI L D+ ++ D++ GGF ++++ Sbjct 1 MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDN-EEILDLVDGGFNINSE 59 Query 63 FSAEKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKV 122 +S +YEL+KMDGA+VL+ D +I YAN L+P+ +I T ETGTRHRTA+R+AKQT K+ Sbjct 60 YSPAYIYELAKMDGALVLTSDRKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKI 119 Query 123 VIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELEN 182 IA+S+RRNII++Y + KYV+ ++SK QAI TLEKY ++ + L +LE ++ Sbjct 120 AIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEKYVAVLERVTNNLNILEFQD 179 Query 183 RVTLADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY 242 TL DV + + ++RIVEEI YI+ELG EGRL MQL EL ++ VLLI DY Sbjct 180 LATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDY 239 Query 243 SSEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVAR 302 +++E +Q+ I++ LGY L D LVS RGYR+ V R Sbjct 240 CYDKMEYNDVYKEIQELSAEDLLDLDIIAKELGY---VGKSLIDTLVSPRGYRISNKVPR 296 Query 303 IPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 IP ++ N+V F L I +A E+L +VEGIGE RARAI + ++ + Sbjct 297 IPSNVIENLVGHFGKLKYILEAGNEELDQVEGIGEARARAIKNGLRRIREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridium perfringens SM101] Sequence ID: Q0SQB6.1 Length: 354 Range 1: 1 to 347 Score:263 bits(671), Expect:1e-84, Method:Compositional matrix adjust., Identities:149/351(42%), Positives:221/351(62%), Gaps:4/351(1%) Query 3 VKSLVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTD 62 ++++ EL + +K++SPGT LR+ LD+I+ A G LI L D+ ++ D++ GGF ++++ Sbjct 1 MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDN-EEILDLVDGGFNINSE 59 Query 63 FSAEKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKV 122 +S +YEL+KMDGA+VL+ D +I YAN L+P+ +I T ETGTRHRTA+R+AKQT K+ Sbjct 60 YSPAYIYELAKMDGALVLTSDRKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKI 119 Query 123 VIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELEN 182 IA+S+RRNII++Y + KYV+ ++SK QAI TLEKY ++ + L +LE ++ Sbjct 120 AIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEKYVAVLERVTNNLNILEFQD 179 Query 183 RVTLADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY 242 TL DV + + ++RIVEEI YI+ELG EGRL MQL EL ++ VLLI DY Sbjct 180 LATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDY 239 Query 243 SSEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVAR 302 +++E +Q+ I++ LGY L D LVS RGYR+ + R Sbjct 240 CYDKMEYNDVYKEIQELSAEDLLDLDIIAKELGY---VGKSLIDTLVSPRGYRISSKIPR 296 Query 303 IPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 IP ++ N+V F L I +A E+L +VEGIGE RARAI + ++ + Sbjct 297 IPSNVIENLVGHFGKLKYILEAGNEELDQVEGIGEARARAIKNGLRRIREQ 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus mycoides KBAB4] Sequence ID: A9VN96.1 Length: 357 Range 1: 9 to 348 Score:261 bits(667), Expect:6e-84, Method:Compositional matrix adjust., Identities:142/344(41%), Positives:217/344(63%), Gaps:5/344(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + +I ++L++PGT LR+ +D+++ A G LI L + ++ + ++ GGF ++ FS L Sbjct 9 KSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYN-EQIKSIVDGGFHINCAFSPASL 67 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGA++L+E +KI AN LVPDP+I + ETG RHRTAER+AKQT +V+A+S+ Sbjct 68 YELAKMDGALILNETGSKILIANAQLVPDPSIDSIETGMRHRTAERVAKQTASLVVAISQ 127 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I+LY N +Y + + +++K QAI TLEKYK +N ++ L +LE E VT+++ Sbjct 128 RRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSE 187 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV L +LRI EI YI ELG EGRL R+QL EL D++ LLI DY E+ + Sbjct 188 VVHVLHSVEMVLRIKNEIVSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQ 247 Query 249 EETA-QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 + LQD + + ++LGY Q + + V+ RGYR+ ++R+P I Sbjct 248 DHHQILKKLQDLANTQLLEDSDLVKLLGYPGQMSLEES---VTPRGYRIASKISRVPPLI 304 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 N++ FKTL + +A++ +L VEGIGE RA+ I E + ++ Sbjct 305 IENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQ 348 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus ATCC 14579] Sequence ID: Q81J64.1 Length: 357 Range 1: 9 to 348 Score:261 bits(667), Expect:8e-84, Method:Compositional matrix adjust., Identities:142/344(41%), Positives:217/344(63%), Gaps:5/344(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + +I ++L++PGT LR+ +D+++ A G LI L + ++ + ++ GGF ++ FS L Sbjct 9 KSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYN-EQIKSIVDGGFHINCAFSPASL 67 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGA++L+E +KI AN LVPD +I + ETG RHRTAER+AKQTG +V+A+S+ Sbjct 68 YELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQ 127 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I+LY N +Y + + +++K QAI TLEKYK +N ++ L +LE E VT+++ Sbjct 128 RRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSE 187 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV L +LRI EI YI ELG EGRL R+QL EL D++ LLI DY E+ + Sbjct 188 VVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQ 247 Query 249 EETA-QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 + LQD + + ++LGY Q + + V+ RGYR+ ++R+P I Sbjct 248 DHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEES---VTPRGYRITSKISRVPPLI 304 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 N++ FKTL + +A++ +L VEGIGE RA+ I E + ++ Sbjct 305 IENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQ 348 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus B4264] Sequence ID: B7HJ22.1 Length: 357 Range 1: 9 to 348 Score:261 bits(666), Expect:1e-83, Method:Compositional matrix adjust., Identities:142/344(41%), Positives:217/344(63%), Gaps:5/344(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + +I ++L++PGT LR+ +D+++ A G LI L + ++ + ++ GGF ++ FS L Sbjct 9 KSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYN-EQIKSIVDGGFHINCAFSPASL 67 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGA++L+E +KI AN LVPD +I + ETG RHRTAER+AKQTG +V+A+S+ Sbjct 68 YELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQ 127 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I+LY N +Y + + +++K QAI TLEKYK +N ++ L +LE E VT+++ Sbjct 128 RRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSE 187 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV L +LRI EI YI ELG EGRL R+QL EL D++ LLI DY E+ + Sbjct 188 VVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQ 247 Query 249 EETA-QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 + LQD + + ++LGY Q + + V+ RGYR+ ++R+P I Sbjct 248 DHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEES---VTPRGYRITSKISRVPPLI 304 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 N++ FKTL + +A++ +L VEGIGE RA+ I E + ++ Sbjct 305 IENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQ 348 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus G9842] Sequence ID: B7ISZ3.1 Length: 357 Range 1: 9 to 348 Score:259 bits(662), Expect:4e-83, Method:Compositional matrix adjust., Identities:141/344(41%), Positives:217/344(63%), Gaps:5/344(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + +I ++L++PGT LR+ +D+++ A G LI L + ++ + ++ GGF ++ FS L Sbjct 9 KSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYN-EQIKSIVDGGFHINCAFSPASL 67 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGA++L+E +KI AN LVP+ +I + ETG RHRTAER+AKQTG +V+A+S+ Sbjct 68 YELAKMDGALILNETGSKILIANAQLVPEASIDSIETGMRHRTAERVAKQTGSLVVAISQ 127 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I+LY N +Y + + +++K QAI TLEKYK +N ++ L +LE E VT+++ Sbjct 128 RRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSE 187 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV L +LRI EI YI ELG EGRL R+QL EL D++ LLI DY E+ + Sbjct 188 VVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQ 247 Query 249 EETA-QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 + LQD + + ++LGY Q + + V+ RGYR+ ++R+P I Sbjct 248 DHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEES---VTPRGYRITSKISRVPPLI 304 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 N++ FKTL + +A++ +L VEGIGE RA+ I E + ++ Sbjct 305 IENLINRFKTLQGVCRATIHELDDVEGIGEVRAKKIREGLKRIQ 348 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus halodurans C-125] Sequence ID: Q9KGG0.1 Length: 357 Range 1: 14 to 350 Score:256 bits(655), Expect:4e-82, Method:Compositional matrix adjust., Identities:135/342(39%), Positives:221/342(64%), Gaps:8/342(2%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 +K+++PGT LR +D+++ A G LI L + + + ++ GGF+LD FS LYEL+KM Sbjct 14 LKMVAPGTALRTGIDNVLRAKTGGLIVLGYN-ENMKGIVDGGFYLDCPFSPASLYELAKM 72 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGAI+L+ED TKI YAN L PD I + ETG RHRTAER+AKQTG +VI++S+RRN+I+ Sbjct 73 DGAIILNEDGTKILYANTQLNPDNAISSNETGIRHRTAERVAKQTGNLVISISQRRNVIT 132 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 LY+ + +Y + + +++K QAI TL+KYK ++ +++L LE E VT +V + + Sbjct 133 LYHGHLRYALRDIGVILTKANQAIQTLDKYKSVLDQDITDLGALEFEELVTFHEVSQVMQ 192 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQN 254 + +L I EI Y+ ELG EGRL MQL EL +++ ++LLI DY+ E ++ ++ Sbjct 193 RIHMVLNIKGEILNYVNELGSEGRLITMQLNELVSNLEKEVLLLIQDYAKE--DDVDPED 250 Query 255 ILQDFITRREPSPI---SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNV 311 +L+ + + +I ++LGY +A + + + RGYR+L + R+P +I N+ Sbjct 251 VLEQMMKCSNEELLDDSNILKLLGY--HKAFNVQEQQATPRGYRILHKIPRLPATIVRNL 308 Query 312 VRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 V F+ ++ + +A +++L +VEGIGE RA+ I + +S ++ + Sbjct 309 VHSFENINDMLRADLKELDEVEGIGEARAKLIKDGLSRIQEQ 350 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus thuringiensis str. Al Hakam] Sequence ID: A0R8F5.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus AH820] Sequence ID: B7JK90.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus 03BB102] Sequence ID: C1ET13.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus anthracis str. CDC 684] Sequence ID: C3LJ56.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus anthracis str. A0248] Sequence ID: C3P9M9.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus E33L] Sequence ID: Q63HB6.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [[Bacillus thuringiensis] serovar konkukian str. 97-27] Sequence ID: Q6HPT4.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus ATCC 10987] Sequence ID: Q73FC3.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus anthracis] Sequence ID: Q81VV7.1 Length: 357 Range 1: 9 to 348 Score:256 bits(654), Expect:5e-82, Method:Compositional matrix adjust., Identities:140/344(41%), Positives:217/344(63%), Gaps:5/344(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + +I ++L++PGT LR+ +D+++ A G LI L + ++ + ++ GGF ++ FS L Sbjct 9 KSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYN-EQIKSIVDGGFHINCAFSPASL 67 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGA++L+E +KI AN LVP+ +I + ETG RHRTAER+AKQTG +V+A+S+ Sbjct 68 YELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQ 127 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I+LY N +Y + + +++K QAI TLEKYK +N ++ L +LE E VT+++ Sbjct 128 RRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSE 187 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV L +LRI EI YI ELG EGRL R+QL EL D++ LLI DY E+ + Sbjct 188 VVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQ 247 Query 249 EETA-QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 + LQ+ + + ++LGY Q + + V+ RGYR+ ++R+P I Sbjct 248 DHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEES---VTPRGYRITSKISRVPPLI 304 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 N++ FKTL + +A++ +L VEGIGE RA+ I E + ++ Sbjct 305 IENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQ 348 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus AH187] Sequence ID: B7HQR7.1 Length: 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus cereus Q1] Sequence ID: B9IZG8.1 Length: 357 Range 1: 9 to 348 Score:255 bits(651), Expect:2e-81, Method:Compositional matrix adjust., Identities:139/344(40%), Positives:217/344(63%), Gaps:5/344(1%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + +I ++L++PGT LR+ +D+++ A G LI L + ++ + ++ GGF ++ FS L Sbjct 9 KSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYN-EQIKSIVDGGFHINCAFSPASL 67 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 YEL+KMDGA++L+E +KI +N LVP+ +I + ETG RHRTAER+AKQTG +V+A+S+ Sbjct 68 YELAKMDGALILNETGSKILISNAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQ 127 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 RRN+I+LY N +Y + + +++K QAI TLEKYK +N ++ L +LE E VT+++ Sbjct 128 RRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSE 187 Query 189 VVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVE 248 VV L +LRI EI YI ELG EGRL R+QL EL D++ LLI DY E+ + Sbjct 188 VVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQ 247 Query 249 EETA-QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 + LQ+ + + ++LGY Q + + V+ RGYR+ ++R+P I Sbjct 248 DHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEES---VTPRGYRITSKISRVPPLI 304 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 N++ FKTL + +A++ +L VEGIGE RA+ I E + ++ Sbjct 305 IENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQ 348 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Frankia sp. EAN1pec] Sequence ID: A8LF79.1 Length: 359 Range 1: 17 to 349 Score:254 bits(649), Expect:3e-81, Method:Compositional matrix adjust., Identities:145/338(43%), Positives:214/338(63%), Gaps:10/338(2%) Query 18 ISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKMDGA 77 ++PGT R L+ I+ + GALI L D K E + GGF LD +FSA +L EL+KMDGA Sbjct 17 VAPGTPFRDGLERILRGHTGALIVLGHD-KVVEGLCTGGFELDVEFSATRLRELAKMDGA 75 Query 78 IVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYY 137 IVLS D+ +I A VHLVPDPT+PT E+GTRHRTAER+AKQTG VI+VS+ +II+LY Sbjct 76 IVLSSDLARIVRAAVHLVPDPTVPTEESGTRHRTAERVAKQTGFPVISVSQSMHIIALYV 135 Query 138 KNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLAKGF 197 +YV++ ++S+ QA++TLE+YK +++ L LE+E+ VT+ D + ++++ Sbjct 136 AGRRYVLDGAAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDAI-SVSQRL 194 Query 198 ELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQNIL 256 E++ RI +EI Y+VELG +GRL +QL EL V+ L + DY A +L Sbjct 195 EMVRRIADEIESYVVELGTDGRLLSLQLEELMAGVETERELTVRDYLPVGSRAGNAAQVL 254 Query 257 QDFITRREPSPI----SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVV 312 + ++ P+ + I+RV+G+ A + D +S RGYR+L V R+P + +V Sbjct 255 AE-LSAMSPTDLLDLTVIARVIGF--SGGADILDRQISPRGYRMLAKVPRLPRMVVDRLV 311 Query 313 RMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 F TL ++ A V+DL+ V+G+GE RARA+ E +S L Sbjct 312 DHFSTLQKLLAAGVDDLQAVDGVGETRARAVREGLSRL 349 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Clostridioides difficile 630] Sequence ID: Q18CB2.1 Length: 356 Range 1: 8 to 348 Score:254 bits(648), Expect:4e-81, Method:Compositional matrix adjust., Identities:142/349(41%), Positives:215/349(61%), Gaps:13/349(3%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQ---GGFWLDTDFSA 65 + ++ +K+ISPGT LR L++++ A G LI + + EDV++ GGF ++ ++S Sbjct 8 KNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATN----EDVMKIVDGGFAINAEYSP 63 Query 66 EKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA 125 LYEL+KMDGAIVLS D+ KI +AN L+PD I T ETGTRHRTAER+AKQTG +VI Sbjct 64 SYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAIVIG 123 Query 126 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVT 185 +S+RRN+I++Y N KYVV + + +K QAI TLEKYK ++ ++ L LE + VT Sbjct 124 ISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLEKYKTVLDQAVTNLNALEFNDLVT 183 Query 186 LADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLREL--TEDVDDLLVLLIMDYS 243 + DV + K ++R+ I Y++ELG+EG L MQL EL T +D L+ DY+ Sbjct 184 IYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIF--KDYN 241 Query 244 SEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARI 303 E E + +++ + ++++++LGY ++ D+ + RGYR+L + R+ Sbjct 242 KENTEIKELMKKVKNLNSEELIELVNMAKLLGY--SGFSESMDMPIKTRGYRILSKIHRL 299 Query 304 PLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKH 352 P +I N+V F+ QI AS+E+L +VEGIGE RA I + +K Sbjct 300 PTAIIENLVNYFENFQQILDASIEELDEVEGIGEIRATYIKNGLIKMKQ 348 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Frankia alni ACN14a] Sequence ID: Q0RBN2.1 Length: 359 Range 1: 17 to 349 Score:250 bits(639), Expect:1e-79, Method:Compositional matrix adjust., Identities:143/338(42%), Positives:215/338(63%), Gaps:10/338(2%) Query 18 ISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKMDGA 77 ++PGT R L+ I+ + GALI L D K E + GGF LD +FSA +L EL+KMDGA Sbjct 17 VAPGTPFRDGLERILRGHTGALIVLGHD-KVVEGLCTGGFELDVEFSATRLRELAKMDGA 75 Query 78 IVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYY 137 IVLS D+ +I A VHLVPDPT+PT E+GTRHRTAER+AKQT VI+VS+ +II+LY Sbjct 76 IVLSSDLQRIVRAAVHLVPDPTVPTEESGTRHRTAERVAKQTEYPVISVSQSMHIIALYV 135 Query 138 KNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLAKGF 197 +YV++ ++S+ QA++TLE+YK +++ L LE+E+ VT+ D + ++++ Sbjct 136 AGRRYVLDGSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDAI-SVSQRL 194 Query 198 ELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQNIL 256 E++ RI +EI Y+VELG +GRL +QL EL V+ L + DY + +A +L Sbjct 195 EMVRRIADEIEGYVVELGTDGRLLSLQLEELMAGVETERELTVRDYLPAGSKAGSAAQVL 254 Query 257 QDFITRREPSPI----SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVV 312 + ++ P+ + ++RV+G+ A + D +S RGYR+L V R+P + +V Sbjct 255 SE-LSAMSPTDLLDLTVLARVIGF--SGGADILDRQISPRGYRMLAKVPRLPRMVVDRLV 311 Query 313 RMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 F TL ++ A V+DL+ V+G+GE RARA+ E +S L Sbjct 312 DHFGTLQKLLAAGVDDLQAVDGVGETRARAVREGLSRL 349 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Bacillus clausii KSM-K16] Sequence ID: Q5WLT9.1 Length: 357 Range 1: 14 to 350 Score:249 bits(637), Expect:2e-79, Method:Compositional matrix adjust., Identities:133/342(39%), Positives:217/342(63%), Gaps:8/342(2%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 +KL++PGT LR +D+++ A G LI L + + +++ GGF++++DFS LYEL+KM Sbjct 14 LKLVAPGTPLRAGIDNVLRAKTGGLIVLGYNSEMM-NIVDGGFFINSDFSPAYLYELAKM 72 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGAI+LSED +I YAN LVP+ I + ETG RHR+AER+AKQTG + I++S+RRN+I+ Sbjct 73 DGAIILSEDGKRILYANTQLVPNNNISSSETGIRHRSAERVAKQTGNLTISISQRRNVIT 132 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 LY Y+Y + + +++K QAI TLEKYK ++ ++ L LE E VT +DV++ + Sbjct 133 LYQGEYRYALKDIGVILTKANQAIQTLEKYKAVLDQGITNLGALEFEQLVTYSDVIQVIH 192 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQN 254 + +LRI +EI+ +I+ELG+EGRL MQL+EL + + + L+ DY+ E ++ + Sbjct 193 RVQMVLRIKQEIQNFILELGDEGRLITMQLKELVSNTEQEALYLLKDYAKERTQD--VKK 250 Query 255 ILQDFITRREPSPI---SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNV 311 L++ T + +I + LGY + + + S RGYR+L + R+P I NV Sbjct 251 TLKELTTLLNEDLLDEQAIIKALGYS--RTSNFLEQPASPRGYRILHRIPRLPSQIIENV 308 Query 312 VRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHR 353 + + L + A+ + L +V+GIGE RA+ I + ++ ++ + Sbjct 309 IDEYGHLSSVMVATEDQLDEVDGIGEARAKMIKDGLNRIQEQ 350 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Frankia casuarinae] Sequence ID: Q2J537.1 Length: 359 Range 1: 17 to 349 Score:245 bits(626), Expect:1e-77, Method:Compositional matrix adjust., Identities:142/338(42%), Positives:213/338(63%), Gaps:10/338(2%) Query 18 ISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKMDGA 77 ++PGT R L+ I+ + GALI L D K E + GGF LD +FSA +L EL+KMDGA Sbjct 17 VAPGTPFRDGLERILRGHTGALIVLGHD-KVVEGLCTGGFELDVEFSATRLRELAKMDGA 75 Query 78 IVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYY 137 IVLS D+ +I A VHLVPDPT+PT E+GTRHRTAER+AKQ VI+VS+ +II+LY Sbjct 76 IVLSSDLQRIVRAAVHLVPDPTVPTEESGTRHRTAERVAKQAEFPVISVSQSMHIIALYV 135 Query 138 KNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLAKGF 197 +YV++ ++S+ QA++TLE+YK +++ L LE+E+ VT+ D + ++++ Sbjct 136 AGRRYVLDGSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDAI-SVSQRL 194 Query 198 ELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQNIL 256 E++ RI +EI Y+VELG +GRL +QL EL V+ L + DY + T +L Sbjct 195 EMVRRIADEIEGYVVELGTDGRLLSLQLEELMAGVETERELTVRDYLPIGSKAGTPAQVL 254 Query 257 QDFITRREPSPI----SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVV 312 + ++ P+ + ++RV+G+ A + D +S RGYR+L V R+P + +V Sbjct 255 GE-LSAMSPTDLLDLTVLARVIGF--SGGADILDRQISPRGYRMLAKVPRLPRMVVDRLV 311 Query 313 RMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 F TL ++ A V+DL+ V+G+GE RARA+ E +S L Sbjct 312 DHFGTLQKLLAAGVDDLQAVDGVGETRARAVREGLSRL 349 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Kineococcus radiotolerans SRS30216 = ATCC BAA-149] Sequence ID: A6W5K2.1 Length: 359 Range 1: 6 to 351 Score:239 bits(609), Expect:4e-75, Method:Compositional matrix adjust., Identities:140/349(40%), Positives:212/349(60%), Gaps:7/349(2%) Query 8 PQELI-EKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAE 66 P E++ + + +++PGT+LR L+ I+ GALI L D + + + GGF LD +FSA Sbjct 6 PDEVLRQTLAILAPGTDLRDGLERILRGRTGALIVLGFD-RVVDSLSTGGFALDVEFSAT 64 Query 67 KLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAV 126 +L EL+KMDGAIVL D+++I A V LVPD +I T E+GTRHRTAER+AKQTG VI+V Sbjct 65 RLRELAKMDGAIVLDRDVSRIVRAAVQLVPDSSIETSESGTRHRTAERVAKQTGFPVISV 124 Query 127 SRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTL 186 S+ I+++Y N +YV+ D ++ + QA+ TLE+Y+ +++ L LE+E+ VT+ Sbjct 125 SQSMRIVAVYTGNRRYVLEGSDAILGRANQALQTLERYRARLDEVTGTLSALEIEDLVTV 184 Query 187 ADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEE 246 DV + + + RI +EI Y+VELG +GRL +QL EL V L++ DY Sbjct 185 RDVCSVVQRIEMVSRIADEISGYVVELGVDGRLLSLQLDELVGGVGPDRELVVRDYLEAS 244 Query 247 VEEETAQNILQDFITRREPSPISIS---RVLGYDVQQAAQLDDVLVSARGYRLLKTVARI 303 E + +L+ + + +S RVLG+ V + D VS +G+RLL V R+ Sbjct 245 RYEGPLEAVLESLAGLHQSDLVDLSQVARVLGFSVGGDSL--DSAVSPKGFRLLNRVPRL 302 Query 304 PLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKH 352 P +I +V F L ++ AS++DL V+G+GE+RARA+ E +S L Sbjct 303 PGAIVERLVDQFGDLQKLLAASIDDLMTVDGVGEQRARAVREGLSRLAE 351 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Streptomyces coelicolor A3(2)] Sequence ID: Q9X8L6.1 Length: 374 Range 1: 26 to 364 Score:237 bits(605), Expect:2e-74, Method:Compositional matrix adjust., Identities:143/346(41%), Positives:211/346(60%), Gaps:16/346(4%) Query 14 KIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSK 73 + ++PGT LR L+ ++ N G LI L D K E + GGF LD +F+A +L EL K Sbjct 26 SLSAVAPGTSLRDGLERVLRGNTGGLIVLGSD-KTVESMCTGGFVLDVEFTATRLRELCK 84 Query 74 MDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNII 133 +DG IVLS D++KI A V L+PDPTIPT ETGTRHRTA+R++KQ G V++VS+ +I Sbjct 85 LDGGIVLSSDLSKILRAGVQLLPDPTIPTEETGTRHRTADRVSKQVGFPVVSVSQSMRLI 144 Query 134 SLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTL 193 +LY + V+ ++S+ QA++TLE+YK +++ L LE+E+ VT+ D V + Sbjct 145 ALYVDGQRRVLEDSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRD-VSAV 203 Query 194 AKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY-------SSE 245 A+ E++ RI EI Y+VELG +GRL +QL EL V+ L++ DY S Sbjct 204 AQRLEMVRRIATEIAEYVVELGTDGRLLALQLDELIAGVEPERELVVRDYVPEPTAKRSR 263 Query 246 EVEEETAQNILQDFITRREPSPIS-ISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIP 304 V+E A+ D ++ E +S ++R LGY + + D VS RG+RLL V R+P Sbjct 264 TVDEALAE---LDKLSHAELLELSTVARALGY--TGSPETLDSAVSPRGFRLLAKVPRLP 318 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 +I +V F L ++ ASV+DL+ V+G+GE RAR++ E +S L Sbjct 319 GAIIDRLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRL 364 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Acidothermus cellulolyticus 11B] Sequence ID: A0LRE3.1 Length: 368 Range 1: 16 to 358 Score:237 bits(605), Expect:2e-74, Method:Compositional matrix adjust., Identities:146/348(42%), Positives:222/348(63%), Gaps:11/348(3%) Query 9 QELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKL 68 + L + I+PGT++R AL+ I+ N GALI L D K E + GGF LD + SA + Sbjct 16 ERLRATLAAIAPGTQMRDALERILRGNTGALIVLGYD-KTVESICSGGFNLDVELSAPLM 74 Query 69 YELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSR 128 EL+KMDGAI+L E T+I ANVHL PDP+IPT E+GTRHR+AER A+QTG VI+VS+ Sbjct 75 RELAKMDGAIILDEKATRIIKANVHLQPDPSIPTNESGTRHRSAERTARQTGFPVISVSQ 134 Query 129 RRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLAD 188 II+LY ++V+++ ++S+ QA++TLE+YK +++ L LE+E+ VT+ D Sbjct 135 SMRIIALYVDGRRHVLDEPSAILSRANQALATLERYKLRLDEVSGTLSALEIEDLVTVRD 194 Query 189 VVRTLAKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY--SSE 245 +A+ E++ RI +EI+ Y+VELG +GRL +QL EL V+ L++ DY ++ Sbjct 195 AA-VVAQRLEMVRRIADEIQGYVVELGTDGRLLSLQLDELLAGVEPERDLIVRDYLPAAA 253 Query 246 EVEEETAQNILQDF--ITRREPSPI-SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVAR 302 + ++L+D +T E + +++RV+G + LD+ VS RGYRLL + R Sbjct 254 GKRGRSVDDVLRDLDALTPEELLDLGTVARVIGCGGTE--NLDNP-VSPRGYRLLAKIPR 310 Query 303 IPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 +P ++ +V F TL ++ ASV+DL+ VEG+GE RAR++ E +S L Sbjct 311 LPCAVIERLVEHFGTLQKLLAASVDDLQAVEGVGESRARSVREGLSRL 358 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Streptomyces avermitilis MA-4680 = NBRC 14893] Sequence ID: Q82EA6.1 Length: 374 Range 1: 26 to 364 Score:235 bits(600), Expect:1e-73, Method:Compositional matrix adjust., Identities:141/343(41%), Positives:209/343(60%), Gaps:10/343(2%) Query 14 KIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSK 73 + ++PGT LR L+ I+ N G LI L D K E + GGF LD +F+A +L EL K Sbjct 26 SLSAVAPGTALRDGLERILRGNTGGLIVLGSD-KTVEAMCTGGFVLDVEFTATRLRELCK 84 Query 74 MDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNII 133 +DG IVLS D++KI A V LVPDP IPT ETGTRHRTA+R++KQ G V++VS+ ++ Sbjct 85 LDGGIVLSSDLSKILRAGVQLVPDPMIPTEETGTRHRTADRVSKQVGFPVVSVSQSMRLV 144 Query 134 SLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTL 193 +LY + V+ ++S+ QA++TLE+YK +++ L LE+E+ VT+ D V + Sbjct 145 ALYVDGMRRVLEDSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRD-VSAV 203 Query 194 AKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETA 252 A+ E++ RI EI Y+VELG +GRL +QL EL V+ L++ DY E + + Sbjct 204 AQRLEMVRRIATEIAEYVVELGTDGRLLALQLDELIAGVEPERELVVRDYVPEPTAKRSR 263 Query 253 ---QNILQ-DFITRREPSPIS-ISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 Q + + D +T E ++ +++ LGY A D VS RG+RLL V R+P +I Sbjct 264 TVDQALYELDALTHAELLELATVAKALGYTGSPEAL--DSAVSPRGFRLLAKVPRLPGAI 321 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 +V F L ++ ASV+DL+ V+G+GE RAR++ E +S L Sbjct 322 IDRLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRL 364 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Streptomyces griseus subsp. griseus NBRC 13350] Sequence ID: B1VSK3.1 Length: 374 Range 1: 26 to 364 Score:226 bits(577), Expect:4e-70, Method:Compositional matrix adjust., Identities:137/344(40%), Positives:210/344(61%), Gaps:12/344(3%) Query 14 KIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSK 73 + ++PG LR L+ I+ N G LI L D K E + GGF LD +F+A +L EL K Sbjct 26 SLSAVAPGMALRDGLERILRGNTGGLIVLGMD-KTVESMCTGGFVLDVEFTATRLRELCK 84 Query 74 MDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNII 133 +DGA++L +D+TKI A V LVPD +I T ETGTRHRTA+R++K G V++VS+ +I Sbjct 85 LDGALILDKDMTKILRAGVQLVPDASIHTEETGTRHRTADRVSKACGFPVVSVSQSMRLI 144 Query 134 SLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTL 193 +LY + V+ + ++S+ QA++TLE+YK +++ L LE+E+ VT+ DV + Sbjct 145 ALYVDGERRVLEESSAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVT-AV 203 Query 194 AKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEET- 251 A+ E++ RI EI Y+VELG +GRL +QL EL V+ L++ DY E + + Sbjct 204 AQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELIAGVEPERELVVRDYVPEPTAKRSR 263 Query 252 --AQNILQ-DFITRRE--PSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLS 306 A+ + + D ++ E P+ ++R LGY + + D VS RG+RLL V R+P + Sbjct 264 TVAEALTELDALSHTELLELPV-VARALGY--SGSPETLDSAVSPRGFRLLAKVPRLPGA 320 Query 307 IGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 I +V F L ++ ASV+DL+ V+G+GE RAR++ E +S L Sbjct 321 IIERLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRL 364 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium tuberculosis H37Ra] Sequence ID: A5U8R1.1 Length: 358 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic-di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium tuberculosis CDC1551] Sequence ID: P9WNW4.1 Length: 358 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic-di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium tuberculosis H37Rv] Sequence ID: P9WNW5.1 Length: 358 Range 1: 9 to 357 Score:225 bits(573), Expect:8e-70, Method:Compositional matrix adjust., Identities:139/353(39%), Positives:204/353(57%), Gaps:10/353(2%) Query 11 LIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYE 70 L E + ++PGT LR L+ I+ GALI L D + E + GGF LD ++A +L E Sbjct 9 LREAVARLAPGTGLRDGLERILRGRTGALIVLGHD-ENVEAICDGGFSLDVRYAATRLRE 67 Query 71 LSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRR 130 L KMDGA+VLS D ++I ANV LVPDP+IPT E+GTRHR+AER A QTG VI+VS Sbjct 68 LCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSM 127 Query 131 NIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVV 190 NI+++Y + ++V+ ++S+ QAI+TLE+YK +++ +L E+E+ VTL DV+ Sbjct 128 NIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVM 187 Query 191 RTLAKGFELLRIVEEIRPY-IVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEE 249 T+ + EL+R + + Y +VELG +GR R+QL EL D L++ DY + Sbjct 188 -TVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPP 246 Query 250 ETAQ-NILQDFITRREPSPI----SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIP 304 T Q N D + + ++++V GY AQ D +S RGYR + + R+ Sbjct 247 STGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQ--DSTLSPRGYRAMAGIPRLQ 304 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 + +VR F TL + AS DL+ V+GIG AR + E +S L S+ Sbjct 305 FAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISD 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2] Sequence ID: A1KPS2.1 Length: 358 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172] Sequence ID: C1AI45.1 Length: 358 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium tuberculosis variant bovis AF2122/97] Sequence ID: Q7TW52.1 Length: 358 Range 1: 9 to 357 Score:224 bits(570), Expect:3e-69, Method:Compositional matrix adjust., Identities:138/353(39%), Positives:204/353(57%), Gaps:10/353(2%) Query 11 LIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYE 70 L E + ++PGT LR L+ I+ GALI L D + E + GGF LD ++A +L E Sbjct 9 LREAVARLAPGTGLRDGLERILRGRTGALIVLGHD-ENVEAICDGGFSLDVRYAATRLRE 67 Query 71 LSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRR 130 L KMDGA+VLS D ++I ANV LVPDP+IPT E+GTRHR+AER A QTG VI+VS Sbjct 68 LCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSM 127 Query 131 NIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVV 190 NI+++Y + ++V+ ++S+ QAI+TLE+YK +++ +L E+E+ VTL DV+ Sbjct 128 NIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVM 187 Query 191 RTLAKGFELLRIVEEIRPY-IVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEE 249 T+ + EL+R + + Y +VELG +GR R+QL EL D L++ DY + Sbjct 188 -TVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPP 246 Query 250 ETAQ-NILQDFITRREPSPI----SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIP 304 T Q N D + + ++++V GY AQ D +S RGYR + + R+ Sbjct 247 STGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQ--DSALSPRGYRAMAGIPRLQ 304 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 + +VR F TL + AS DL+ V+GIG AR + + +S L S+ Sbjct 305 FAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISD 357 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium avium subsp. paratuberculosis K-10] Sequence ID: Q743W9.1 Length: 357 Range 1: 6 to 347 Score:222 bits(566), Expect:8e-69, Method:Compositional matrix adjust., Identities:139/346(40%), Positives:204/346(58%), Gaps:10/346(2%) Query 11 LIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYE 70 L E + ++PGT LR L+ I+ GALI L +D + E + GGF LD ++ +L E Sbjct 6 LRETVARLAPGTGLRDGLERILRGRTGALIVLGND-ENVEAICDGGFALDVRYAPTRLRE 64 Query 71 LSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRR 130 L+KMDGA+VLS D ++I ANV LVPDP+I T E+GTRHR+AER A QTG VI+VS Sbjct 65 LAKMDGAVVLSTDGSRIVRANVQLVPDPSIATDESGTRHRSAERAAIQTGYPVISVSHSM 124 Query 131 NIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVV 190 NI+++Y ++VV ++S+ QAI+TLE+YK +++ +L E+E+ VTL DV+ Sbjct 125 NIVTVYVGGERHVVADSATILSRANQAIATLERYKIRLDEVSRQLSRAEIEDFVTLRDVL 184 Query 191 RTLAKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY--SSEEV 247 T+ + EL+ RI + I +VELG +GR R+QL EL D+ L++ DY S E++ Sbjct 185 -TVVQRLELVRRIGQVIDNDVVELGTDGRQLRLQLDELLGGNDNARELIVRDYHASPEQL 243 Query 248 EEETAQNILQDFITRREPSPI---SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIP 304 E L + + + ++++V GY AQ D VS RGYR L + R+ Sbjct 244 SEAQMTATLDELDALSDTELLDFTALAKVFGYPTTTEAQ--DSAVSPRGYRALAGIPRLQ 301 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 + +VR F TL + AS DL+ ++GIG AR + E +S L Sbjct 302 FAHADLLVRSFGTLQNVLAASASDLQSIDGIGAMWARHVREGLSQL 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Beutenbergia cavernae DSM 12333] Sequence ID: C5C1B3.1 Length: 359 Range 1: 14 to 349 Score:221 bits(564), Expect:2e-68, Method:Compositional matrix adjust., Identities:134/340(39%), Positives:201/340(59%), Gaps:8/340(2%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 ++ ++PGTELR L+ I+ GALI L D + E++ GGF LD FSA +L EL+KM Sbjct 14 LRAVAPGTELRDGLERILRGRTGALIVLGYD-EVVEEMCSGGFVLDVAFSATRLRELAKM 72 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGAIVL T++ A V L+PD I TGE+GTRHRTAER AKQTG VI+VS+ I++ Sbjct 73 DGAIVLDRGATRVLRAAVQLLPDAAIETGESGTRHRTAERAAKQTGFPVISVSQSMRIVA 132 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 +Y ++V+ D ++S+ QA++TLE+YK +++ L LE+E+ VT+ DV + Sbjct 133 IYSDGRRWVLEDSDAILSRANQALATLERYKSRLDEVSGTLSALEIEDLVTVRDVASVVQ 192 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQN 254 + + RI EI Y+ ELG +GRL +QL EL +V L++ DY + A + Sbjct 193 RLEMVRRISVEIAGYVDELGTDGRLLSLQLDELIGNVGPERELVVSDYV--DARRAAALD 250 Query 255 ILQDFITRREPSP----ISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYN 310 + + R + + + I++V G LD V RG+R+L + R+P + Sbjct 251 DVLAGLARLDSTDLIDLVKIAQVRGLGGPGGDALDSA-VGPRGHRMLSKIPRLPSPVIGA 309 Query 311 VVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 +V F TL ++ ASVEDL+ V+G+G RAR++ E +S L Sbjct 310 MVDHFGTLQKMLSASVEDLQLVDGVGALRARSVREGLSRL 349 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycobacterium avium 104] Sequence ID: A0QAA9.1 Length: 357 Range 1: 6 to 347 Score:221 bits(563), Expect:3e-68, Method:Compositional matrix adjust., Identities:139/346(40%), Positives:203/346(58%), Gaps:10/346(2%) Query 11 LIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYE 70 L E + ++PGT LR L+ I+ GALI L +D + E + GGF LD ++ +L E Sbjct 6 LRETVARLAPGTGLRDGLERILRGRTGALIVLGND-ENVEAICDGGFALDVRYAPTRLRE 64 Query 71 LSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRR 130 L+KMDGA+VLS D ++I ANV LVPDP+I T E+GTRHR+AER A QTG VI+VS Sbjct 65 LAKMDGAVVLSTDGSRIVRANVQLVPDPSIATDESGTRHRSAERAAIQTGYPVISVSHSM 124 Query 131 NIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVV 190 NI+++Y ++VV ++S+ QAI+TLE+YK +++ +L E+E+ VTL DV+ Sbjct 125 NIVTVYVGGERHVVADSATILSRANQAIATLERYKIRLDEVSRQLSRAEIEDFVTLRDVL 184 Query 191 RTLAKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY--SSEEV 247 T+ + EL+ RI + I +VELG +GR R+QL EL D+ L++ DY S E + Sbjct 185 -TVVQRLELVRRIGQVIDNDVVELGTDGRQLRLQLDELLGGNDNARELIVRDYHASPEPL 243 Query 248 EEETAQNILQDFITRREPSPI---SISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIP 304 E L + + + ++++V GY AQ D VS RGYR L + R+ Sbjct 244 SEAQMTATLDELDALSDTELLDFTALAKVFGYPTTTEAQ--DSAVSPRGYRALAGIPRLQ 301 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 + +VR F TL + AS DL+ ++GIG AR + E +S L Sbjct 302 FAHADLLVRSFGTLQNVLAASASDLQSIDGIGAMWARHVREGLSQL 347 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Fusobacterium nucleatum subsp. nucleatum ATCC 25586] Sequence ID: Q8RGW9.1 Length: 349 Range 1: 1 to 342 Score:218 bits(555), Expect:4e-67, Method:Compositional matrix adjust., Identities:128/347(37%), Positives:211/347(60%), Gaps:6/347(1%) Query 6 LVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSA 65 + Q+L++ I ++PG+ LR+ +D I++A GALI + D + E V GGF +D D++ Sbjct 1 MTKQDLMDIIVKVAPGSPLREGVDYILDAGIGALIIIGYDDE-VEKVRDGGFLIDCDYTP 59 Query 66 EKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIA 125 E+++ELSKMDGAI+L++D +KI YANVH+ PD + T E+GTRHRTAER AK + V+A Sbjct 60 ERIFELSKMDGAIILNDDCSKILYANVHVQPDNSYSTTESGTRHRTAERAAKHLKREVVA 119 Query 126 VSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVT 185 +S R+ ++LY N KY + D L +V Q + TLE Y+ N+ L L +LEL++ VT Sbjct 120 ISERKKNVTLYKGNLKYRLKNFDELNIEVGQVLKTLESYRHVLNRSLDSLTILELDDLVT 179 Query 186 LADVVRTLAKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSS 244 + DV TL + FE++ RI EEI Y++ELG GRL MQ+ EL D+D+ + DY Sbjct 180 VLDVANTLQR-FEMVRRISEEITRYLLELGSRGRLVNMQVSELIWDLDEEEESFLKDYID 238 Query 245 EEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIP 304 +E + ++ + L ++ LGY +++ + D ++A+GYR+L+ ++++ Sbjct 239 DETDTDSVRRYLHSLSDSELLEVENVVVALGY--SKSSSVFDNKIAAKGYRVLEKISKLT 296 Query 305 LSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 +V +K + +I + + ED ++ I + + +A+ I+ LK Sbjct 297 KKDVEKIVNTYKDISEIQEVTDEDFSAIK-ISKFKIKALRAGINRLK 342 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic-di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Mycolicibacterium smegmatis MC2 155] Sequence ID: A0R564.1 Length: 372 Range 1: 21 to 362 Score:218 bits(554), Expect:1e-66, Method:Compositional matrix adjust., Identities:139/354(39%), Positives:201/354(56%), Gaps:26/354(7%) Query 11 LIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYE 70 L E + ++PGT LR L+ I+ GALI L D E + GGF LD ++ +L E Sbjct 21 LRETLGRLAPGTPLRDGLERILRGRTGALIVLGYD-DSVEAICDGGFVLDVRYAPTRLRE 79 Query 71 LSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRR 130 LSKMDGA+VLS D ++I ANV LVPDP+IPT E+GTRHR+AER A QTG VI+VS Sbjct 80 LSKMDGAVVLSSDGSRILRANVQLVPDPSIPTDESGTRHRSAERTAIQTGYPVISVSHSM 139 Query 131 NIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVV 190 +I+++Y ++VV ++S+ Q I+TLE+YK +++ +L E+E+ VTL DV+ Sbjct 140 SIVTVYVAGERHVVPDSATILSRANQTIATLERYKGRLDEVSRQLSTAEIEDFVTLRDVM 199 Query 191 RTLAKGFELL-RIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEE 249 T+ + E++ RI EI +VELG +GR ++QL EL D + L++ DY + Sbjct 200 -TVVQRLEMVRRISLEIDADVVELGTDGRQLKLQLDELVGDNETARELIVRDYHANPDPP 258 Query 250 ETAQ-------------NILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRL 296 AQ + L DF ++RV GY AQ D +S+RGYR Sbjct 259 TAAQVAATLEELDSLSDSELLDFTV--------LARVFGYPSTAEAQ--DSAMSSRGYRA 308 Query 297 LKTVARIPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 + + R+ + +VR F +L + AS +DL+ V+GIG AR I E +S L Sbjct 309 MAAIPRLQFAHVDLLVRSFGSLQNLLAASADDLQSVDGIGSMWARHIREGLSLL 362 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Corynebacterium glutamicum ATCC 13032] Sequence ID: Q8NMB2.1 Length: 366 Range 1: 28 to 366 Score:211 bits(537), Expect:2e-64, Method:Compositional matrix adjust., Identities:129/344(38%), Positives:199/344(57%), Gaps:12/344(3%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 ++ ++PGT LR LD I+ + GALI + DD + + GGF D F+A +L EL KM Sbjct 28 LQRLAPGTPLRDGLDRIVRGHTGALIVIGDD-ENVSSICDGGFEFDVSFAATRLRELCKM 86 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGA++LS D+ +I ANV L+P PT PT E+GTRHR+AER A TG VIAVS +N I+ Sbjct 87 DGAVILSSDLERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTIT 146 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 LY + +++ Q L+++ QA+ T+E+Y+D +++ + L + EL + VT+ DVV + Sbjct 147 LYVEGKSHMLEQPAALLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQ 206 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY-------SSEEV 247 + L R+ E I ++ELG++ + ++QL EL D D +I DY + EE+ Sbjct 207 REEMLRRVGEIIDGDVLELGKDAKEIQIQLSELRGDNDRERESIIADYLVTDGIPADEEI 266 Query 248 EEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 A + + +P +I+RVLG + A LD+ V+ RGYR L + R+ + Sbjct 267 --HAALEAISHLDDKALLNPANIARVLGLPPTEEA-LDEP-VTPRGYRTLNRIPRVQKFL 322 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 ++ F LD + ASVEDL V+G+G AR I++ + L Sbjct 323 MDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS 366 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Corynebacterium glutamicum R] Sequence ID: A4QH66.1 Length: 366 Range 1: 28 to 366 Score:210 bits(535), Expect:5e-64, Method:Compositional matrix adjust., Identities:129/344(38%), Positives:199/344(57%), Gaps:12/344(3%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 ++ ++PGT LR +LD I+ + GALI + DD + + GGF D F+A +L EL KM Sbjct 28 LQRLAPGTPLRDSLDRIVRGHTGALIVIGDD-ENVTSICDGGFEFDVPFAATRLRELCKM 86 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DGA++LS DI +I ANV L+P PT PT E+GTRHR+AER A TG VIAVS +N I+ Sbjct 87 DGAVILSSDIERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTIT 146 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 LY + +++ Q L+++ QA+ T+E+Y+D +++ + L + EL + VT+ DVV + Sbjct 147 LYVEGKAHMLEQPSTLLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQ 206 Query 195 KGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY-------SSEEV 247 + L R+ E I ++ELG++ + ++QL EL D D +I DY + EE+ Sbjct 207 REEMLRRVGEIIDGDVLELGKDAKQIQIQLSELRGDNDRERESIIADYLVTDGIPADEEI 266 Query 248 EEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 A + + P +I+R+LG + A LD+ V+ RGYR L + R+ + Sbjct 267 --YAALEAISHLDDKALLKPANIARILGLPPTEEA-LDEP-VAPRGYRTLNRIPRVQKFL 322 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 ++ F LD + ASVEDL V+G+G AR I++ + L Sbjct 323 MDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS 366 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Corynebacterium efficiens YS-314] Sequence ID: Q8FMH9.1 Length: 356 Range 1: 16 to 355 Score:210 bits(534), Expect:6e-64, Method:Compositional matrix adjust., Identities:129/343(38%), Positives:199/343(58%), Gaps:8/343(2%) Query 13 EKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELS 72 + ++ ++PGT LR LD I+ + GALI L D+ + + GGF D F+A +L EL Sbjct 16 DTLQRLAPGTPLRDGLDRIVRGHTGALIVLGDE-ENVTSICDGGFEFDVTFAATRLRELC 74 Query 73 KMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNI 132 KMDGA+VLS D +I ANV L+P P+ PT E+GTRHR+AER A QTG VIAVS +N Sbjct 75 KMDGAVVLSSDGERIKRANVQLIPSPSWPTQESGTRHRSAERTALQTGVPVIAVSESQNT 134 Query 133 ISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRT 192 I+LY + +++ + L+++ QA+ T+E+Y+D +++ + L + EL N T+ DVV Sbjct 135 ITLYVEGKSHILEEPSTLLNRANQALGTMERYRDRLDQVNTRLHMAELHNYATVIDVVSV 194 Query 193 LAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDY--SSEEVEEE 250 + + L R+ E I ++ELG E + ++QL EL D D +I DY + +E Sbjct 195 IQREEMLRRVGETIDTNVLELGREAKQIQIQLTELRGDNDRERGYIIADYLVTDGIPTDE 254 Query 251 TAQNILQDFITRREPS---PISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSI 307 T L+ + S P +I+R+LG + A LD+ +V RGYR L V R+ + Sbjct 255 TITEALEAVSGLDDKSLMKPSNIARILGLPPTEEA-LDEPVV-PRGYRTLNRVPRVQKFL 312 Query 308 GYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 +V F L ++ ASVE++ V+G+G AR I++ ++ L Sbjct 313 MDKLVGEFGNLHALTSASVEEISAVDGVGSLWARHITDGLARL 355 >RecName: Full=DNA integrity scanning protein DisA; AltName: Full=Cyclic di-AMP synthase; Short=c-di-AMP synthase; AltName: Full=Diadenylate cyclase [Cutibacterium acnes KPA171202] Sequence ID: Q6AAZ9.1 Length: 344 Range 1: 1 to 334 Score:178 bits(452), Expect:6e-52, Method:Compositional matrix adjust., Identities:117/338(35%), Positives:188/338(55%), Gaps:6/338(1%) Query 15 IKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKM 74 + L++PGT +R+ LD I+N G LI L D P+ V GGF LD + + L ELSKM Sbjct 1 MALLAPGTPIREGLDRIVNGRTGGLIVLGDGPE-INGVCSGGFPLDVRLTPQALRELSKM 59 Query 75 DGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIIS 134 DG +V+S D +I A VH VPD ++PT ETGTRHRTA+RL++QTG V+ VS +++S Sbjct 60 DGGLVVSSDHERIKAAAVHFVPDGSLPTLETGTRHRTADRLSQQTGVPVVVVSASMSVMS 119 Query 135 LYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLA 194 L+ +Y++ + + L+++ QA++TL Y+ L LE+ ++V + DV +A Sbjct 120 LFLNGRRYLIERPEQLLARANQALATLASYRGRLVDEAENLTTLEIRDQVQVRDVA-AVA 178 Query 195 KGFELLRIVE-EIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEET-A 252 + E+ R ++ E+R Y+ LG EGRL ++Q EL+ V+DL LL DY V + Sbjct 179 QRVEMWRRIDAEVRGYVSALGVEGRLVQLQRNELSLGVEDLGRLLTDDYRPNSVAPGGFS 238 Query 253 QNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVV 312 + LQ + ++ + ++ A D + ARG+R L + + ++ Sbjct 239 LSGLQKLSWEDLLNVTMVAETI--NLGPAEHPLDSPIRARGHRQLTLMTDLSSRTIQRII 296 Query 313 RMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSL 350 F L + AS +L ++G+G +RAR I + + S+ Sbjct 297 DHFSDLQSLVSASTSELGDIKGVGLRRAREIRQGLESI 334 >RecName: Full=UvrABC system protein C; Short=Protein UvrC; AltName: Full=Excinuclease ABC subunit C [Lawsonia intracellularis PHE/MN1-00] Sequence ID: Q1MQH2.1 Length: 621 Range 1: 561 to 621 Score:42.4 bits(98), Expect:0.005, Method:Compositional matrix adjust., Identities:22/62(35%), Positives:41/62(66%), Gaps:5/62(8%) Query 296 LLKTVARIPLSIGYNVVRM----FKTLDQISKASVEDLKKVEGIGEKRARAISESISSLK 351 LL + RIP IG ++ FKT++ ++ A+++DL+ + GIGE +AR ++E + SL+ Sbjct 561 LLGELLRIP-GIGQATAKLLWSHFKTVEAMTCATIKDLEAIPGIGEAKARMLAERLQSLR 619 Query 352 HR 353 ++ Sbjct 620 NQ 621 >RecName: Full=UvrABC system protein C; Short=Protein UvrC; AltName: Full=Excinuclease ABC subunit C [Thermoanaerobacter pseudethanolicus ATCC 33223] Sequence ID: B0K791.1 Length: 615 Range 1: 581 to 611 Score:42.4 bits(98), Expect:0.005, Method:Compositional matrix adjust., Identities:19/31(61%), Positives:27/31(87%), Gaps:0/31(0%) Query 315 FKTLDQISKASVEDLKKVEGIGEKRARAISE 345 FK++++I +ASVEDLKKVEG+ EK A+A+ E Sbjct 581 FKSIEEIKRASVEDLKKVEGMNEKAAQAVYE 611 >RecName: Full=UvrABC system protein C; Short=Protein UvrC; AltName: Full=Excinuclease ABC subunit C [Thermoanaerobacter sp. X514] Sequence ID: B0K680.1 Length: 615 Range 1: 581 to 611 Score:42.4 bits(98), Expect:0.005, Method:Compositional matrix adjust., Identities:19/31(61%), Positives:27/31(87%), Gaps:0/31(0%) Query 315 FKTLDQISKASVEDLKKVEGIGEKRARAISE 345 FK++++I +ASVEDLKKVEG+ EK A+A+ E Sbjct 581 FKSIEEIKRASVEDLKKVEGMNEKAAQAVYE 611 >RecName: Full=DNA ligase; AltName: Full=Polydeoxyribonucleotide synthase [NAD(+)] [Thermobifida fusca YX] Sequence ID: Q47SC6.1 Length: 745 Range 1: 586 to 633 Score:40.8 bits(94), Expect:0.014, Method:Compositional matrix adjust., Identities:21/48(44%), Positives:32/48(66%), Gaps:0/48(0%) Query 310 NVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE 357 ++ R F++LD I++AS E+L+ VEGIG AR+I + S HR+ E Sbjct 586 DLARHFRSLDAIAQASEEELEAVEGIGPTIARSIVDWFSVDWHREIVE 633 >RecName: Full=DNA ligase; AltName: Full=Polydeoxyribonucleotide synthase [NAD(+)] [Chlamydia pneumoniae] Sequence ID: Q9Z934.1 Length: 662 Range 1: 495 to 564 Score:40.4 bits(93), Expect:0.021, Method:Compositional matrix adjust., Identities:27/76(36%), Positives:41/76(53%), Gaps:7/76(9%) Query 278 VQQAAQLD-DVLVSARGYRLLKTVARIPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIG 336 ++QA +D D + A G L I + + + F+TLD++ A+ E+L +EGIG Sbjct 495 IEQAKHVDLDRFLVALGIPL------IGIGVATVLAGHFETLDRVISATFEELLSLEGIG 548 Query 337 EKRARAISESISSLKH 352 EK A AI+E S H Sbjct 549 EKVAHAIAEYFSDSTH 564