FT   INIT_MET        1
FT                   /note="Removed; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   CHAIN           2..2207
FT                   /note="Genome polyprotein"
FT                   /id="PRO_0000426611"
FT   CHAIN           2..879
FT                   /note="P1"
FT                   /id="PRO_0000426612"
FT   CHAIN           2..340
FT                   /note="Capsid protein VP0"
FT                   /id="PRO_0000426613"
FT   CHAIN           2..69
FT                   /note="Capsid protein VP4"
FT                   /id="PRO_0000426614"
FT   CHAIN           70..340
FT                   /note="Capsid protein VP2"
FT                   /id="PRO_0000426615"
FT   CHAIN           341..578
FT                   /note="Capsid protein VP3"
FT                   /id="PRO_0000426616"
FT   CHAIN           579..879
FT                   /note="Capsid protein VP1"
FT                   /id="PRO_0000426617"
FT   CHAIN           880..1454
FT                   /note="P2"
FT                   /id="PRO_0000426618"
FT   CHAIN           880..1028
FT                   /note="Protease 2A"
FT                   /id="PRO_0000426619"
FT   CHAIN           1029..1125
FT                   /note="Protein 2B"
FT                   /id="PRO_0000040107"
FT   CHAIN           1126..1454
FT                   /note="Protein 2C"
FT                   /id="PRO_0000040108"
FT   CHAIN           1455..2207
FT                   /note="P3"
FT                   /id="PRO_0000426620"
FT   CHAIN           1455..1563
FT                   /note="Protein 3AB"
FT                   /id="PRO_0000426621"
FT   CHAIN           1455..1541
FT                   /note="Protein 3A"
FT                   /id="PRO_0000040109"
FT   CHAIN           1542..1563
FT                   /note="Viral protein genome-linked"
FT                   /id="PRO_0000426622"
FT   CHAIN           1564..2207
FT                   /note="Protein 3CD"
FT                   /id="PRO_0000426623"
FT   CHAIN           1564..1746
FT                   /note="Protease 3C"
FT                   /id="PRO_0000426624"
FT   CHAIN           1747..2207
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000426625"
FT   TOPO_DOM        2..1518
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        1519..1534
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1535..2207
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1230..1386
FT                   /note="SF3 helicase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00551"
FT   DOMAIN          1564..1742
FT                   /note="Peptidase C3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01222"
FT   DOMAIN          1973..2088
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
FT   NP_BIND         1254..1261
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00551"
FT   ZN_FING         1394..1411
FT                   /note="C4-type"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   REGION          579..599
FT                   /note="Amphipatic alpha-helix"
FT                   /evidence="ECO:0000255"
FT   REGION          1126..1264
FT                   /note="Oligomerization"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   REGION          1126..1198
FT                   /note="Membrane-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   REGION          1147..1151
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   REGION          1438..1445
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   REGION          1449..1454
FT                   /note="Oligomerization"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   REGION          1455..1477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        899
FT                   /note="For protease 2A activity"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   ACT_SITE        917
FT                   /note="For protease 2A activity"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   ACT_SITE        988
FT                   /note="For protease 2A activity"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   ACT_SITE        1603
FT                   /note="For protease 3C activity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01222"
FT   ACT_SITE        1634
FT                   /note="For protease 3C activity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01222"
FT   ACT_SITE        1710
FT                   /note="For protease 3C activity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01222"
FT   METAL           934
FT                   /note="Zinc; structural"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QF31"
FT   METAL           936
FT                   /note="Zinc; structural"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QF31"
FT   METAL           994
FT                   /note="Zinc; structural"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QF31"
FT   METAL           996
FT                   /note="Zinc; via pros nitrogen; structural"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QF31"
FT   METAL           1394
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   METAL           1397
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   METAL           1406
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   METAL           1411
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   METAL           1979
FT                   /note="Magnesium 1; catalytic; for RdRp activity"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   METAL           1979
FT                   /note="Magnesium 2; catalytic; for RdRp activity"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   METAL           2074
FT                   /note="Magnesium 1; catalytic; for RdRp activity"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   METAL           2074
FT                   /note="Magnesium 2; catalytic; for RdRp activity"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   SITE            69..70
FT                   /note="Cleavage; by autolysis"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   SITE            340..341
FT                   /note="Cleavage; by protease 3C"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   SITE            879..880
FT                   /note="Cleavage; by autolysis"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   SITE            1028..1029
FT                   /note="Cleavage; by protease 3C"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   SITE            1125..1126
FT                   /note="Cleavage; by protease 3C"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   SITE            1150
FT                   /note="Involved in the interaction with host RTN3"
FT                   /evidence="ECO:0000250|UniProtKB:Q66478"
FT   SITE            1454..1455
FT                   /note="Cleavage; by protease 3C"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   SITE            1541..1542
FT                   /note="Cleavage; by protease 3C"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   SITE            1563..1564
FT                   /note="Cleavage; by protease 3C"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   SITE            1746..1747
FT                   /note="Cleavage; by protease 3C"
FT                   /evidence="ECO:0000250|UniProtKB:P03301"
FT   MOD_RES         1544
FT                   /note="O-(5'-phospho-RNA)-tyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   LIPID           2
FT                   /note="N-myristoyl glycine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P03300"
FT   STRAND          4..7
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           17..19
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           23..25
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          26..29
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           36..38
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           51..54
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          57..59
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          63..65
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          83..87
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          90..96
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           103..105
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            113..115
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           126..128
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          138..140
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          147..151
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           153..155
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           159..167
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          168..180
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          187..197
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          203..207
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           213..216
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           219..221
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          226..228
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          235..237
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           246..248
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            249..252
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           255..260
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          261..267
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            268..270
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          272..278
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          282..287
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            289..291
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          295..307
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          315..331
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            348..351
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          363..365
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          379..382
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           384..387
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            399..403
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           405..408
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          410..413
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          422..427
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            429..431
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            433..437
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           439..444
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          447..452
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          454..460
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          469..475
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          477..479
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           485..488
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          491..497
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          499..501
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          503..508
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          513..520
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          529..536
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          546..556
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          561..565
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           625..627
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           635..637
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           655..659
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          663..671
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          683..687
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           695..700
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          703..725
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          732..738
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   HELIX           751..754
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          756..758
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          760..764
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          770..774
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          779..785
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   TURN            800..803
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          812..815
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          817..822
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          831..849
FT                   /evidence="ECO:0000244|PDB:1EAH"
FT   STRAND          859..862
FT                   /evidence="ECO:0000244|PDB:1EAH"