RID: XT9E113J014 Job Title:(R)-citramalate synthase Program: BLASTP Database: swissprot Non-redundant UniProtKB/SwissProt sequences Query #1: RecName: Full=(R)-citramalate synthase CimA; AltName: Full=LiCMS [Leptospira interrogans serovar Lai str. 56601] Query ID: sp|Q8F3Q1.1 Length: 516 Sequences producing significant alignments: Scientific Common Max Total Query E Per. Acc. Description Name Name Taxid Score Score cover Value Ident Len Accession RecName: Full=(R)-citramalate synthase CimA; AltName: Full=LiC... Leptospira i... NA 189518 1053 1053 100% 0.0 100.00 516 Q8F3Q1.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Methanopyrus... NA 190192 239 239 98% 1e-71 32.55 499 Q8TYB1.1 RecName: Full=Putative (R)-citramalate synthase CimA... Methanotherm... NA 187420 238 238 98% 2e-71 34.06 496 O26819.1 RecName: Full=Putative (R)-citramalate synthase CimA... Methanopyrus... NA 190192 226 226 89% 2e-66 33.77 509 Q8TYM1.1 RecName: Full=(R)-citramalate synthase CimA [Methanocaldococcu... Methanocaldo... NA 243232 223 223 92% 2e-65 32.70 491 Q58787.1 RecName: Full=2-isopropylmalate synthase; AltName:... Methanocaldo... NA 243232 220 220 98% 3e-64 32.62 518 Q58595.1 RecName: Full=Putative (R)-citramalate synthase CimA... Archaeoglobu... NA 224325 216 216 98% 6e-63 32.02 489 O29305.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Methanotherm... NA 187420 216 216 98% 7e-63 29.84 505 O27525.1 RecName: Full=Putative (R)-citramalate synthase CimA... Methanosphae... NA 521011 213 213 97% 1e-61 32.28 500 B8GEI1.1 RecName: Full=Putative (R)-citramalate synthase CimA... Methanosarci... NA 188937 211 211 97% 5e-61 30.94 483 Q8TJJ1.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Archaeoglobu... NA 224325 211 211 99% 5e-61 30.58 503 O30020.1 RecName: Full=Putative (R)-citramalate synthase CimA... Methanoculle... NA 368407 206 206 98% 7e-59 30.30 503 A3CUF2.1 RecName: Full=Putative (R)-citramalate synthase CimA... Methanosarci... NA 192952 200 200 97% 4e-57 31.55 483 P58966.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Ignicoccus h... NA 453591 197 197 73% 7e-57 34.75 399 A8AB61.1 RecName: Full=2-isopropylmalate synthase; AltName:... Gloeothece c... NA 65393 200 200 99% 1e-56 30.47 536 B7KJX8.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Methanosarci... NA 192952 194 194 97% 2e-54 27.90 516 P58968.1 RecName: Full=2-isopropylmalate synthase; AltName:... Desulforamul... NA 349161 192 192 99% 7e-54 29.94 505 A4J181.1 RecName: Full=2-isopropylmalate synthase; AltName:... Rippkaea ori... NA 41431 193 193 100% 7e-54 29.54 536 B7JYP4.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Methanosarci... NA 188937 192 192 97% 8e-54 27.90 515 Q8THA5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Methylorubru... NA 441620 191 191 98% 2e-53 29.81 520 B1ZDN3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aquifex aeol... NA 224324 190 190 98% 5e-53 30.04 520 O67862.2 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodopirellu... NA 243090 189 189 98% 1e-52 30.48 527 Q7UI51.2 RecName: Full=2-isopropylmalate synthase; AltName:... Candidatus D... NA 477974 188 188 98% 3e-52 30.40 509 B1I1Y1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Clostridium ... NA 431943 188 188 98% 3e-52 30.21 514 A5MZ76.1 RecName: Full=2-isopropylmalate synthase; AltName:... Cupriavidus ... NA 264198 187 187 98% 5e-52 29.15 513 Q473V1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 93059 188 188 92% 5e-52 30.00 536 A9BB43.1 RecName: Full=2-isopropylmalate synthase; AltName:... Ralstonia ps... NA 267608 187 187 84% 5e-52 30.91 513 Q8XXP1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Syntrophus a... NA 56780 187 187 90% 6e-52 31.50 516 Q2LWJ3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Cupriavidus ... NA 381666 186 186 98% 1e-51 29.15 513 Q0KCT8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 167539 186 186 99% 2e-51 28.97 536 Q7VBG1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Cupriavidus ... NA 266264 186 186 91% 2e-51 29.67 513 Q1LPX2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Polaromonas ... NA 365044 185 185 98% 3e-51 28.85 512 A1VN06.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nitratidesul... NA 883 185 185 99% 3e-51 28.38 514 B8DM91.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nitratirupto... NA 387092 185 185 89% 3e-51 31.86 514 A6Q4V5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Sediminispir... NA 573413 184 184 84% 4e-51 29.21 505 E1R5X1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Polaromonas ... NA 296591 184 184 98% 6e-51 29.13 513 Q12B47.1 RecName: Full=2-isopropylmalate synthase; AltName:... Picosynechoc... NA 32049 185 185 100% 7e-51 28.78 533 B1XLQ9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Acidovorax s... NA 232721 184 184 98% 9e-51 28.85 512 A1W6T7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pyrococcus f... NA 186497 183 183 98% 1e-50 30.81 499 Q8U2A2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 167555 183 183 99% 2e-50 29.53 539 A2C3L7.1 RecName: Full=2-isopropylmalate synthase; AltName:... [Acidovorax]... NA 535289 183 183 98% 2e-50 28.65 512 B9MA32.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 59920 183 183 99% 3e-50 29.53 539 Q46K01.1 RecName: Full=2-isopropylmalate synthase; AltName:... Paracidovora... NA 397945 182 182 98% 3e-50 29.38 512 A1TRT4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Polynucleoba... NA 452638 182 182 98% 4e-50 28.43 515 B1XUJ3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Synechococcu... NA 32051 183 183 91% 4e-50 29.35 540 A5GM47.1 RecName: Full=2-isopropylmalate synthase; AltName:... Crocosphaera... NA 43989 182 182 98% 5e-50 30.35 537 B1WQQ4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Thermosynech... NA 197221 182 182 98% 5e-50 29.40 535 Q8DJ32.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bradyrhizobi... NA 224911 182 182 99% 6e-50 28.73 520 Q89GB0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Oceanobacill... NA 221109 182 182 91% 7e-50 30.35 515 Q8EN67.1 RecName: Full=2-isopropylmalate synthase; AltName:... Microcystis ... NA 449447 182 182 99% 8e-50 28.89 533 B0JGK2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Methylococcu... NA 243233 181 181 99% 8e-50 28.21 514 Q605K7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Methylibium ... NA 420662 181 181 98% 1e-49 28.79 513 A2SHL8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Solidesulfov... NA 573370 181 181 98% 1e-49 27.66 513 C4XPA8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Methylacidip... NA 481448 180 180 92% 3e-49 29.90 506 B3DX88.1 RecName: Full=2-isopropylmalate synthase; AltName:... Trichormus v... NA 240292 180 180 100% 4e-49 29.24 531 Q3MBA3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 167546 180 180 99% 5e-49 29.05 546 A3PDH0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Microcystis ... NA 1126 179 179 99% 5e-49 29.21 533 P94907.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aromatoleum ... NA 76114 179 179 97% 5e-49 29.09 511 Q5NXN2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Methylobacte... NA 460265 179 179 98% 6e-49 28.65 520 B8IHS8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Carboxydothe... NA 246194 179 179 99% 8e-49 30.23 509 Q3AEQ5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bradyrhizobi... NA 114615 179 179 99% 8e-49 28.35 525 A4YZ76.1 RecName: Full=2-isopropylmalate synthase; AltName:... Heliomicrobi... NA 498761 178 178 98% 1e-48 28.85 512 B0TCR1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pelotomaculu... NA 370438 178 178 84% 1e-48 29.86 505 A5D4W0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shouchella c... NA 66692 178 178 90% 2e-48 29.38 514 Q5WEN3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Leptothrix c... NA 395495 177 177 98% 2e-48 27.10 513 B1XYA8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Dictyoglomus... NA 515635 177 177 98% 2e-48 30.33 503 B8E2W9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Synechococcu... NA 64471 178 178 99% 2e-48 28.04 540 Q0IBI3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Variovorax p... NA 543728 177 177 98% 2e-48 27.83 512 C5CYP2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nostoc sp. P... NA 103690 178 178 100% 2e-48 28.86 531 P48575.2 RecName: Full=2-isopropylmalate synthase; Short=IPMS; AltName:... Saccharolobu... NA 273057 174 174 72% 2e-48 30.46 386 Q97W36.2 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodopseudom... NA 316058 177 177 99% 3e-48 28.57 524 Q2IUT4.1 RecName: Full=2-isopropylmalate synthase; Short=IPMS; AltName:... Sulfurisphae... NA 273063 174 174 71% 3e-48 30.60 386 Q974X3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Caulobacter ... NA 366602 177 177 84% 4e-48 29.91 524 B0T0G9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Paraburkhold... NA 391038 177 177 98% 5e-48 29.38 516 B2JDN6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Synechococcu... NA 110662 177 177 99% 6e-48 28.60 540 Q3AIA2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Thiobacillus... NA 292415 176 176 98% 8e-48 28.88 511 Q3SHE7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 74547 176 176 92% 1e-47 28.40 540 Q7TUV5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodopseudom... NA 316055 175 175 100% 1e-47 28.00 521 Q07PI3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Halothermoth... NA 373903 175 175 98% 2e-47 29.09 515 B8CX21.1 RecName: Full=2-isopropylmalate synthase; AltName:... Synechocysti... NA 1111708 176 176 87% 2e-47 30.04 533 P48576.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 59919 176 176 86% 2e-47 30.64 546 Q7V121.1 RecName: Full=2-isopropylmalate synthase; AltName:... Caulobacter ... NA 565050 175 175 84% 2e-47 30.00 524 B8H607.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 59922 176 176 92% 2e-47 28.60 540 A2C859.1 RecName: Full=2-isopropylmalate synthase; AltName:... Parabacteroi... NA 435591 174 174 98% 2e-47 27.01 500 A6LDN1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 93060 175 175 91% 3e-47 30.12 546 A8G5D5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 146891 175 175 91% 3e-47 29.92 546 A2BRP4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 74546 175 175 91% 4e-47 29.92 546 Q31AF9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 482957 174 174 98% 5e-47 29.09 514 Q39ED5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bradyrhizobi... NA 288000 174 174 99% 5e-47 28.68 523 A5EP79.1 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodoferax f... NA 338969 174 174 84% 6e-47 29.77 512 Q21VZ1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Candidatus V... NA 412965 173 173 98% 7e-47 28.90 511 A5CWZ3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Polynucleoba... NA 312153 173 173 98% 7e-47 28.82 515 A4SXR0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Neisseria me... NA 122586 173 173 84% 7e-47 29.62 517 Q9JZG1.1 RecName: Full=2-isopropylmalate synthase; Short=IPMS; AltName:... Sulfolobus a... NA 330779 170 170 72% 8e-47 29.46 386 Q4JA78.1 RecName: Full=2-isopropylmalate synthase; AltName:... Listeria wel... NA 386043 173 173 96% 8e-47 28.80 512 A0AK92.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pyrococcus a... NA 272844 172 172 90% 8e-47 31.32 486 Q9UZ08.1 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodopseudom... NA 395960 173 173 99% 9e-47 28.19 524 B3QCX5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Dictyoglomus... NA 309799 173 173 98% 1e-46 30.66 503 B5YEF4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Parasynechoc... NA 84588 173 173 99% 1e-46 28.68 540 Q7U892.1 RecName: Full=2-isopropylmalate synthase; AltName:... Anoxybacillu... NA 491915 172 172 97% 1e-46 29.23 514 B7GH19.1 RecName: Full=2-isopropylmalate synthase; AltName:... Neisseria me... NA 272831 172 172 84% 1e-46 29.62 517 A1KTV6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodopseudom... NA 316057 173 173 99% 1e-46 27.81 524 Q138Z2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Halalkalibac... NA 272558 172 172 91% 2e-46 28.07 515 Q9K8E8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodopseudom... NA 258594 172 172 99% 2e-46 28.00 524 Q6N858.1 RecName: Full=2-isopropylmalate synthase; AltName:... Synechococcu... NA 316279 173 173 89% 2e-46 29.05 540 Q3AYY2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Neisseria me... NA 122587 172 172 84% 2e-46 29.62 517 Q9JUK6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Listeria inn... NA 272626 172 172 90% 2e-46 28.93 512 Q92A28.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 360107 171 171 99% 3e-46 29.25 504 A7I0N8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Listeria mon... NA 169963 172 172 96% 3e-46 28.40 512 Q8Y5R9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Candidatus B... NA 291272 172 172 98% 3e-46 28.54 517 Q493R0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aliarcobacte... NA 367737 171 171 98% 4e-46 30.38 517 A8ES07.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 331272 171 171 98% 4e-46 28.71 514 A0K933.1 RecName: Full=2-isopropylmalate synthase; AltName:... Ruminiclostr... NA 394503 171 171 97% 5e-46 28.40 508 B8I1T7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Wolinella su... NA 273121 171 171 99% 6e-46 29.45 519 Q7M9W4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Acetivibrio ... NA 203119 171 171 84% 6e-46 30.65 511 A3DF94.1 RecName: Full=2-isopropylmalate synthase; AltName:... Listeria mon... NA 568819 171 171 96% 7e-46 28.21 512 C1KWT1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 395019 171 171 84% 7e-46 29.25 514 A9AJN4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Candidatus R... NA 413404 171 171 98% 7e-46 29.92 511 A1AWA1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Afipia carbo... NA 504832 171 171 99% 9e-46 27.94 519 B6JB87.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus pum... NA 315750 170 170 91% 1e-45 30.58 517 A8FFW5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Trichodesmiu... NA 203124 171 171 100% 1e-45 28.04 541 Q112U2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 269482 170 170 91% 1e-45 28.96 514 A4JGE0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Leptospira i... NA 267671 169 169 84% 1e-45 27.59 501 Q72RL9.2 RecName: Full=2-isopropylmalate synthase; AltName:... Prochlorococ... NA 167542 170 170 91% 2e-45 29.70 546 A2BX52.1 RecName: Full=2-isopropylmalate synthase; AltName:... Neisseria go... NA 242231 171 171 84% 2e-45 29.40 597 Q5F8D4.2 RecName: Full=2-isopropylmalate synthase; AltName:... Listeria mon... NA 552536 169 169 96% 2e-45 28.40 512 B8DBU4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 216591 169 169 98% 3e-45 28.60 514 B4E5N2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Lactococcus ... NA 272622 169 169 95% 3e-45 29.18 513 Q02YX5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodopseudom... NA 316056 169 169 98% 4e-45 27.04 521 Q212A9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Verminephrob... NA 391735 168 168 98% 5e-45 28.13 512 A1WNY5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nitrosococcu... NA 323261 168 168 98% 5e-45 27.17 511 Q3J877.1 RecName: Full=2-isopropylmalate synthase; AltName:... Hydrogenovib... NA 317025 168 168 98% 8e-45 29.37 514 Q31I16.1 RecName: Full=2-isopropylmalate synthase; AltName:... Dechloromona... NA 159087 168 168 97% 8e-45 27.33 513 Q47BI0.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Pyrobaculum ... NA 178306 164 164 69% 9e-45 31.27 384 Q8ZW35.2 RecName: Full=2-isopropylmalate synthase; AltName:... Nitrobacter ... NA 323098 167 167 99% 1e-44 27.83 519 Q3SQ49.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nitrobacter ... NA 323097 167 167 99% 1e-44 27.83 520 Q1QJV3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 320373 167 167 84% 1e-44 29.19 515 A3N7K7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Brevibacillu... NA 358681 167 167 98% 2e-44 27.38 512 C0Z9C8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 339670 167 167 84% 2e-44 29.02 514 Q0BDB9.1 RecName: Full=Homocitrate synthase; Short=HCS [Sulfurisphaera... Sulfurisphae... NA 273063 165 165 85% 2e-44 29.78 460 Q971S5.1 RecName: Full=2-isopropylmalate synthase 2; AltName:... Caldanaeroba... NA 273068 163 163 66% 2e-44 31.81 384 Q8RCF9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Chromobacter... NA 243365 166 166 98% 3e-44 28.68 512 Q7P0H2.1 RecName: Full=Homocitrate synthase AksA; AltName:... Methanotherm... NA 187420 163 163 74% 4e-44 30.83 391 O27667.1 RecName: Full=2-isopropylmalate synthase; AltName:... Burkholderia... NA 398577 166 166 84% 4e-44 28.80 514 B1YTR7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nitrosomonas... NA 335283 166 166 91% 5e-44 29.69 510 Q0AGN5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 360106 165 165 98% 6e-44 28.52 506 A0RQK7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Thermotoga s... NA 126740 165 165 98% 9e-44 28.88 513 B1L8U2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Geobacillus ... NA 471223 165 165 90% 1e-43 29.98 515 C5D5M0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Thermotoga p... NA 390874 165 165 98% 1e-43 29.79 513 A5IJM2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Gloeobacter ... NA 251221 165 165 98% 1e-43 27.59 538 Q7NI93.1 RecName: Full=Homocitrate synthase AksA; AltName:... Methanocaldo... NA 243232 162 162 72% 1e-43 30.21 406 Q57926.3 RecName: Full=2-isopropylmalate synthase; AltName:... Thermotoga n... NA 309803 164 164 98% 2e-43 28.93 513 B9KB95.1 RecName: Full=2-isopropylmalate synthase; AltName:... Psychromonas... NA 357804 164 164 97% 3e-43 28.96 519 A1SRG8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nitrosospira... NA 323848 163 163 97% 3e-43 28.65 510 Q2YBW0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Photorhabdus... NA 243265 164 164 98% 3e-43 27.97 520 Q7N129.1 RecName: Full=2-isopropylmalate synthase; AltName:... Candidatus B... NA 203907 163 163 98% 3e-43 29.17 519 Q7VQJ6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 107806 163 163 99% 3e-43 27.20 519 Q9ZEY8.3 RecName: Full=2-isopropylmalate synthase; AltName:... Lactococcus ... NA 272623 163 163 95% 4e-43 30.26 513 Q02141.1 RecName: Full=2-isopropylmalate synthase; AltName:... Synechococcu... NA 316278 163 163 89% 5e-43 28.16 537 A5GRZ0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 279808 162 162 97% 5e-43 28.65 510 Q4L7U0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Yersinia ent... NA 393305 162 162 98% 7e-43 27.89 520 A1JJH7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 118101 162 162 99% 7e-43 27.07 516 O85070.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus sub... NA 224308 162 162 90% 8e-43 28.01 518 P94565.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nitrosomonas... NA 228410 162 162 84% 8e-43 28.34 510 Q820M0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Proteus mira... NA 529507 162 162 98% 9e-43 28.14 519 B4F194.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus vel... NA 326423 162 162 91% 1e-42 28.34 518 A7Z7B8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 396513 162 162 96% 1e-42 28.32 510 B9DMJ6.1 RecName: Full=Homocitrate synthase [Rhodobacter capsulatus] Rhodobacter ... NA 1061 159 159 71% 1e-42 30.26 382 Q07179.1 RecName: Full=2-isopropylmalate synthase; AltName:... Geobacillus ... NA 420246 162 162 90% 1e-42 29.68 515 A4IRH8.1 RecName: Full=Methylthioalkylmalate synthase 3, chloroplastic;... Arabidopsis ... thale cress 3702 161 161 74% 2e-42 29.63 503 Q9FN52.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pectobacteri... NA 218491 162 162 98% 2e-42 27.99 532 Q6D0G8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Geobacillus ... NA 1422 161 161 90% 2e-42 29.54 515 Q8RL85.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella o... NA 211586 161 161 98% 2e-42 27.38 522 Q8E9N2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Sodalis glos... NA 343509 161 161 98% 2e-42 27.00 525 Q2NVW3.1 RecName: Full=Homocitrate synthase; Short=HCS [Sulfolobus... Sulfolobus a... NA 330779 160 160 70% 2e-42 29.67 468 Q4J989.1 RecName: Full=2-isopropylmalate synthase; AltName:... Candidatus E... NA 1408204 161 161 89% 3e-42 29.44 516 B1H0A7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pasteurella ... NA 272843 161 161 98% 3e-42 27.84 518 Q9CJN5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pectobacteri... NA 561230 161 161 98% 3e-42 27.47 532 C6DEV8.1 RecName: Full=2-isopropylmalate synthase 1; AltName:... Caldanaeroba... NA 273068 158 158 72% 3e-42 30.21 397 Q8RDK3.1 RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus... Saccharolobu... NA 429572 159 159 85% 3e-42 28.73 461 C3MPM7.1 RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus... Saccharolobu... NA 427317 159 159 85% 3e-42 28.73 461 C3MYM1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus cyt... NA 315749 160 160 90% 4e-42 28.42 506 A7GMU1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Yersinia pes... NA 386656 160 160 98% 5e-42 27.70 520 A4TQA2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus lic... NA 279010 159 159 90% 8e-42 28.57 518 Q65GI8.1 RecName: Full=Methylthioalkylmalate synthase 2, chloroplastic;... Arabidopsis ... thale cress 3702 159 159 75% 1e-41 30.22 506 Q8VX04.1 RecName: Full=2-isopropylmalate synthase; AltName:... Histophilus ... NA 228400 158 158 84% 2e-41 28.70 517 B0USF6.1 RecName: Full=Homocitrate synthase AksA; AltName:... Methanopyrus... NA 190192 155 155 74% 2e-41 30.99 397 Q8TW28.1 RecName: Full=2-isopropylmalate synthase 1, chloroplastic;... Arabidopsis ... thale cress 3702 160 160 98% 3e-41 28.28 631 Q9LPR4.2 RecName: Full=2-isopropylmalate synthase; AltName:... Olsenella ul... NA 633147 158 158 84% 3e-41 27.43 511 E1QWZ1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Geobacillus ... NA 235909 158 158 90% 3e-41 29.47 515 Q5KWJ3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Deinococcus ... NA 243230 157 157 99% 4e-41 27.72 522 Q9RUA9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 360104 157 157 98% 7e-41 27.59 504 A7ZES2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Histophilus ... NA 205914 157 157 84% 7e-41 28.48 517 Q0I2G1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Lysinibacill... NA 444177 157 157 90% 8e-41 28.33 511 B1HR98.1 RecName: Full=2-isopropylmalate synthase; AltName:... Serratia pro... NA 399741 157 157 98% 8e-41 26.89 524 A8G9R1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 118105 156 156 97% 1e-40 28.21 502 Q9EVG4.1 RecName: Full=Homocitrate synthase AksA; AltName:... Methanosarci... NA 188937 154 154 73% 1e-40 30.87 405 Q8TKQ6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella s... NA 425104 156 156 98% 2e-40 27.24 523 A8FQ83.1 RecName: Full=Homocitrate synthase [Cereibacter sphaeroides] Cereibacter ... NA 1063 153 153 72% 2e-40 30.53 391 Q01181.1 RecName: Full=2-isopropylmalate synthase; AltName:... Streptococcu... NA 637909 155 155 73% 2e-40 30.39 520 D3HCJ2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella s... NA 94122 155 155 98% 3e-40 26.81 522 A0L1R0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella s... NA 60480 155 155 98% 3e-40 26.81 522 Q0HE65.1 RecName: Full=2-isopropylmalate synthase; AltName:... Xylella fast... NA 160492 155 155 84% 3e-40 28.38 519 Q9PCG3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella s... NA 60481 155 155 98% 3e-40 26.81 522 Q0HZT4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 176279 155 155 91% 3e-40 28.07 511 Q5HMF9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus cer... NA 361100 155 155 90% 4e-40 27.00 506 B9IUZ0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus ant... NA 568206 154 154 90% 4e-40 27.31 506 C3L9Q7.1 RecName: Full=Methylthioalkylmalate synthase 1-2, chloroplasti... Eutrema japo... NA 75806 154 154 72% 5e-40 29.52 503 P0DO78.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 196620 154 154 97% 6e-40 26.90 509 P58899.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella l... NA 323850 154 154 98% 6e-40 27.06 523 A3QIP0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus thu... NA 412694 154 154 90% 7e-40 27.14 506 A0RBL2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 426430 154 154 97% 8e-40 26.90 509 A6QIQ3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 359786 154 154 97% 8e-40 26.90 509 A5IUK3.1 RecName: Full=2-isopropylmalate synthase 2, chloroplastic;... Arabidopsis ... thale cress 3702 155 155 98% 1e-39 27.90 631 Q9C550.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus myc... NA 315730 153 153 90% 1e-39 27.10 506 A9VLG7.1 RecName: Full=Homocitrate synthase [Azotobacter vinelandii] Azotobacter ... NA 354 150 150 71% 1e-39 29.16 385 P05342.2 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella b... NA 402882 154 154 98% 1e-39 27.05 522 A6WIB5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella b... NA 325240 153 153 98% 1e-39 26.86 522 A3CZK5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella s... NA 351745 153 153 98% 1e-39 26.86 522 A1REY0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Photobacteri... NA 298386 153 153 84% 1e-39 27.99 514 Q6LV24.1 PUTATIVE PSEUDOGENE: RecName: Full=Putative 2-isopropylmalate... Buchnera aph... NA 224915 150 150 73% 2e-39 28.68 390 Q89A49.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus cer... NA 288681 153 153 90% 2e-39 26.93 506 Q63DX8.1 RecName: Full=2-isopropylmalate synthase; AltName:... [Bacillus th... NA 281309 153 153 90% 2e-39 26.79 506 Q6HLF3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus cer... NA 572264 153 153 90% 2e-39 27.10 506 C1EMA9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Xylella fast... NA 405441 153 153 84% 2e-39 28.22 519 B2I596.1 RecName: Full=2-isopropylmalate synthase; AltName:... Stenotrophom... NA 522373 153 153 85% 2e-39 28.88 528 B2FT78.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus cer... NA 405535 152 152 90% 2e-39 27.10 506 B7JFY5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 273036 152 152 97% 2e-39 26.90 509 Q2YUF2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella f... NA 318167 152 152 99% 3e-39 25.56 522 Q07WG9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella w... NA 392500 152 152 97% 3e-39 26.45 523 B1KKZ4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella b... NA 407976 152 152 98% 3e-39 26.86 522 B8E4K4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 282458 152 152 97% 4e-39 26.71 509 Q6GF16.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella b... NA 399599 152 152 98% 4e-39 26.67 522 A9KY13.1 RecName: Full=2-isopropylmalate synthase; AltName:... Staphylococc... NA 342451 152 152 91% 5e-39 27.20 511 Q49Z12.1 RecName: Full=2-isopropylmalate synthase; AltName:... Stenotrophom... NA 391008 152 152 85% 7e-39 28.66 528 B4SI67.1 RecName: Full=2-isopropylmalate synthase; AltName:... Citrobacter ... NA 290338 150 150 98% 1e-38 27.80 523 A8ALM5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Salmonella e... NA 476213 150 150 98% 1e-38 26.99 523 C0Q5H1.1 RecName: Full=Methylthioalkylmalate synthase 1, chloroplastic;... Arabidopsis ... thale cress 3702 150 150 72% 1e-38 29.95 506 Q9FG67.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 118117 150 150 97% 2e-38 26.86 503 Q9EVH0.1 RecName: Full=Homocitrate synthase [Pantoea agglomerans] Pantoea aggl... NA 549 148 148 71% 2e-38 29.63 400 Q52070.1 RecName: Full=2-isopropylmalate synthase; AltName:... Xanthomonas ... NA 1203463 150 150 84% 2e-38 27.54 520 P58900.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 407148 150 150 99% 2e-38 26.67 511 A8FP35.1 RecName: Full=2-isopropylmalate synthase; AltName:... Salmonella e... NA 554290 150 150 98% 2e-38 27.15 523 B5BLB5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Xanthomonas ... NA 316273 150 150 84% 2e-38 27.49 520 Q3BPJ9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Salmonella e... NA 1016998 150 150 98% 3e-38 26.80 523 A9MZK0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Erwinia tasm... NA 465817 150 150 98% 3e-38 27.10 522 B2VDA7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Salmonella e... NA 423368 150 150 98% 3e-38 26.80 523 B4SU36.1 RecName: Full=2-isopropylmalate synthase; AltName:... Salmonella e... NA 41514 149 149 98% 3e-38 26.50 523 A9MQD8.1 RecName: Full=Homocitrate synthase AksA; AltName:... Methanosarci... NA 192952 147 147 73% 3e-38 30.29 405 P58967.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 354242 149 149 99% 4e-38 26.86 511 A1W1X2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella a... NA 326297 149 149 97% 4e-38 26.77 522 A1S2E0.1 RecName: Full=Methylthioalkylmalate synthase 1-1, chloroplasti... Eutrema japo... NA 75806 149 149 72% 5e-38 28.43 509 P0DO77.1 RecName: Full=2-isopropylmalate synthase; AltName:... Salmonella e... NA 90370 149 149 98% 5e-38 26.80 523 Q8Z9I0.3 RecName: Full=2-isopropylmalate synthase; AltName:... Vibrio chole... NA 579112 149 149 84% 6e-38 27.31 516 C3LR32.1 RecName: Full=2-isopropylmalate synthase; AltName:... Salmonella e... NA 454166 149 149 98% 6e-38 26.60 523 B5F7U9.1 RecName: Full=Probable 2-isopropylmalate synthase; AltName:... Glycine max soybean 3847 149 149 98% 6e-38 27.00 565 Q39891.1 RecName: Full=2-isopropylmalate synthase; AltName:... Tolumonas au... NA 595494 149 149 99% 7e-38 27.05 521 C4LAV7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 198804 148 148 99% 1e-37 25.81 518 O85063.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 195099 148 148 99% 1e-37 26.86 511 Q5HS76.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aeromonas hy... NA 380703 148 148 99% 1e-37 26.83 524 A0KGM9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Paraglacieco... NA 3042615 148 148 99% 1e-37 25.95 519 Q15QR4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Escherichia ... NA 574521 148 148 98% 1e-37 27.41 523 B7UIC4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella d... NA 318161 148 148 99% 1e-37 25.86 522 Q12SE7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 192222 147 147 99% 2e-37 26.67 511 Q9PLV9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aliivibrio s... NA 316275 147 147 84% 2e-37 26.67 515 B6ELK0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Campylobacte... NA 360109 147 147 99% 2e-37 26.77 511 A7H667.1 RecName: Full=2-isopropylmalate synthase; AltName:... Xanthomonas ... NA 360094 147 147 84% 2e-37 27.38 520 B2SNG9.2 RecName: Full=2-isopropylmalate synthase; AltName:... Shigella son... NA 300269 147 147 98% 3e-37 27.41 523 Q3Z5T6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Escherichia ... NA 585397 147 147 98% 3e-37 27.41 523 B7MNT2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Escherichia ... NA 439855 147 147 98% 3e-37 27.41 523 B1LG11.1 RecName: Full=2-isopropylmalate synthase; AltName:... Xanthomonas ... NA 291331 147 147 84% 3e-37 27.11 520 Q5H4C6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Escherichia ... NA 405955 147 147 98% 3e-37 27.41 523 A1A7C2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Vibrio atlan... NA 575788 146 146 84% 4e-37 27.27 515 B7VIF2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Escherichia ... NA 444450 147 147 98% 4e-37 27.41 523 B5YZB0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shigella fle... NA 623 146 146 98% 4e-37 27.41 523 Q83SP0.3 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 168385 146 146 97% 5e-37 26.83 503 Q9EVH6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shigella fle... NA 373384 146 146 98% 5e-37 27.41 523 Q0T8C4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella p... NA 225849 146 146 97% 5e-37 25.87 523 B8CM39.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 98793 146 146 99% 5e-37 26.00 518 P48571.1 RecName: Full=2-isopropylmalate synthase; AltName:... Edwardsiella... NA 634503 146 146 98% 5e-37 24.47 526 C5B7R4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Vibrio vulni... NA 196600 146 146 84% 5e-37 27.05 515 Q7MP77.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 118118 145 145 97% 6e-37 26.60 502 Q9EVI8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Escherichia ... NA 595496 146 146 98% 6e-37 27.41 523 C4ZPZ7.1 RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus... Saccharolobu... NA 273057 145 145 85% 7e-37 28.73 461 Q97ZE0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 372461 145 145 99% 7e-37 26.91 516 Q5WQ01.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aeromonas sa... NA 382245 146 146 99% 7e-37 26.19 524 A4SR62.1 RecName: Full=2-isopropylmalate synthase A; AltName:... Solanum penn... NA 28526 146 146 98% 1e-36 26.24 589 O04973.1 RecName: Full=2-isopropylmalate synthase; AltName:... Enterobacter... NA 399742 145 145 98% 1e-36 25.97 523 A4W6H9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aliivibrio f... NA 388396 145 145 84% 1e-36 26.64 515 B5FGH4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Aliivibrio f... NA 312309 144 144 84% 2e-36 26.64 515 Q5E856.1 RecName: Full=2-isopropylmalate synthase; AltName:... Haemophilus ... NA 281310 144 144 84% 2e-36 28.35 515 Q4QLS4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shigella dys... NA 300267 144 144 98% 3e-36 27.22 523 Q32K20.1 RecName: Full=2-isopropylmalate synthase; AltName:... Haemophilus ... NA 374930 144 144 84% 3e-36 28.19 515 A5UD85.1 RecName: Full=2-isopropylmalate synthase; AltName:... Haemophilus ... NA 71421 144 144 84% 3e-36 28.22 515 P43861.1 RecName: Full=Homocitrate synthase 2 [Nostoc sp. PCC 7120 =... Nostoc sp. P... NA 103690 141 141 68% 4e-36 30.45 376 P58637.1 RecName: Full=2-isopropylmalate synthase; AltName:... Klebsiella p... NA 272620 143 143 98% 5e-36 26.26 523 A6T4L9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Xanthomonas ... NA 509169 143 143 84% 5e-36 27.60 520 B0RP28.1 RecName: Full=2-phosphonomethylmalate synthase [Streptomyces... Streptomyces... NA 359131 140 140 68% 6e-36 27.76 373 Q0ZQ46.1 RecName: Full=2-isopropylmalate synthase; AltName:... Klebsiella v... NA 507522 143 143 98% 7e-36 26.36 523 B5Y1W2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella p... NA 398579 143 143 98% 8e-36 25.91 523 A8H9A1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Shewanella h... NA 458817 142 142 85% 1e-35 26.43 523 B0TQM0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Paenibacillu... NA 481743 142 142 89% 1e-35 26.15 518 D3EBC1.1 RecName: Full=2-isopropylmalate synthase B; AltName:... Solanum penn... NA 28526 143 143 98% 2e-35 26.92 612 O04974.1 RecName: Full=2-isopropylmalate synthase; AltName:... Vibrio parah... NA 223926 141 141 84% 3e-35 26.39 515 Q87SS7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Cronobacter ... NA 290339 140 140 98% 9e-35 25.43 523 A7MIC5.1 RecName: Full=Homocitrate synthase 1 [Nostoc sp. PCC 7120 =... Nostoc sp. P... NA 103690 137 137 68% 1e-34 29.86 377 Q44290.2 RecName: Full=2-isopropylmalate synthase; AltName:... Salinibacter... NA 761659 139 139 91% 2e-34 25.39 546 D5HB86.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 168386 137 137 85% 4e-34 27.05 437 Q9EVE3.1 RecName: Full=Homocitrate synthase [Frankia sp. FaC1] Frankia sp. ... NA 1857 134 134 73% 1e-33 27.56 401 P54610.1 RecName: Full=Homocitrate synthase [Azotobacter chroococcum... Azotobacter ... NA 355 134 134 70% 2e-33 28.61 382 P23122.1 RecName: Full=Homocitrate synthase; Short=HCS [Pyrococcus... Pyrococcus h... NA 70601 132 132 68% 3e-33 29.83 361 O59390.1 RecName: Full=2-isopropylmalate synthase; AltName:... Acidimicrobi... NA 525909 134 134 84% 1e-32 25.95 516 C7M0E4.1 RecName: Full=Homocitrate synthase [Frankia alni] Frankia alni NA 1859 129 129 66% 4e-32 27.06 351 Q47884.1 RecName: Full=Homocitrate synthase; Short=HCS [Pyrococcus abys... Pyrococcus a... NA 272844 129 129 66% 5e-32 29.15 361 Q9V1J1.1 RecName: Full=(R)-citramalate synthase [Synechocystis sp. PCC... Synechocysti... NA 1111708 131 131 91% 2e-31 24.95 547 P74269.1 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 98799 130 130 84% 2e-31 28.60 515 P58898.1 RecName: Full=(R)-citramalate synthase [Thermotoga maritima MSB8] Thermotoga m... NA 243274 125 125 87% 8e-30 26.24 538 Q9WZ22.1 RecName: Full=Homocitrate synthase; Short=HCS [Thermus... Thermus ther... NA 262724 122 122 71% 2e-29 26.22 376 O87198.2 RecName: Full=(R)-citramalate synthase [Aquifex aeolicus VF5] Aquifex aeol... NA 224324 123 123 88% 6e-29 24.58 528 O66682.1 RecName: Full=(R)-citramalate synthase [Streptomyces coelicolo... Streptomyces... NA 100226 123 123 89% 6e-29 26.58 534 O86511.1 RecName: Full=Homocitrate synthase [Klebsiella pneumoniae] Klebsiella p... NA 573 117 117 72% 1e-27 25.59 381 P05345.2 RecName: Full=2-isopropylmalate synthase; AltName:... Buchnera aph... NA 98797 114 114 69% 2e-26 27.57 375 O31287.1 RecName: Full=(R)-citramalate synthase; AltName:... Sulfolobus a... NA 330779 114 114 66% 7e-26 27.14 523 Q4J6H1.1 RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS;... Saccharomyce... NA 559292 108 108 73% 4e-24 26.87 440 Q12122.1 RecName: Full=Homocitrate synthase, cytosolic isozyme; Short=H... Saccharomyce... NA 559292 107 107 70% 4e-24 26.67 428 P48570.1 RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS;... Schizosaccha... NA 284812 107 107 70% 6e-24 26.81 418 Q9Y823.1 RecName: Full=2-isopropylmalate synthase; AltName:... Thermus ther... NA 274 104 104 57% 1e-23 29.77 331 Q56216.1 RecName: Full=Homocitrate synthase [Azospirillum brasilense] Azospirillum... NA 192 105 105 68% 2e-23 26.29 376 P70728.1 RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS;... Penicillium ... NA 500485 101 101 70% 1e-21 26.22 474 O94225.1 RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS;... Yarrowia lip... NA 284591 99.4 99.4 71% 5e-21 26.13 446 Q12726.1 RecName: Full=Homocitrate synthase subunit alpha [Clostridium... Clostridium ... NA 1501 95.9 95.9 49% 5e-21 28.46 269 Q00853.1 RecName: Full=(R)-citramalate synthase; AltName:... Geobacter su... NA 243231 99.4 99.4 89% 7e-21 22.45 528 Q74C76.1 RecName: Full=2-phosphinomethylmalate synthase; Short=PMS;... Streptomyces... NA 1912 95.1 95.1 50% 1e-19 30.99 440 Q9LCB4.1 RecName: Full=Citrate (Re)-synthase; AltName: Full=Re-citrate... Clostridium ... NA 431943 94.0 94.0 64% 2e-19 27.64 453 A5N6T4.1 RecName: Full=2-isopropylmalate synthase 2; AltName:... Leptospira i... NA 189518 90.5 90.5 58% 3e-18 26.23 428 Q8F8T4.1 RecName: Full=Citrate (Re)-synthase; AltName: Full=Re-citrate... Syntrophus a... NA 56780 85.1 85.1 57% 3e-16 24.76 629 Q2LTE1.2 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Rhodococcus ... NA 101510 70.9 70.9 23% 5e-12 33.61 339 Q0S815.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Rhodococcus ... NA 632772 70.1 70.1 23% 8e-12 33.90 339 C1BAJ4.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 6; Short=HOA 6;... Rhodococcus ... NA 101510 69.7 69.7 53% 1e-11 28.14 354 Q0RXC3.1 RecName: Full=Citrate (Re)-synthase; AltName: Full=Re... Dehalococcoi... NA 255470 70.1 70.1 58% 1e-11 25.91 415 P0DO96.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Rhodococcus ... NA 234621 69.7 69.7 23% 1e-11 33.90 347 C0ZPX1.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Nocardia far... NA 247156 69.3 69.3 23% 2e-11 33.90 345 Q5Z2N2.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Streptomyces... NA 100226 68.2 68.2 24% 3e-11 31.15 338 Q99PZ1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Desulfitobac... NA 138119 68.9 68.9 97% 3e-11 22.37 557 Q24PE3.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Desulfitobac... NA 272564 66.6 66.6 50% 1e-10 24.44 333 B8G187.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Mycolicibact... NA 350054 66.2 66.2 23% 1e-10 32.79 352 A4T7U4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Acetoanaerob... NA 499177 67.0 67.0 88% 2e-10 23.54 567 E3PVH7.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Mycolicibact... NA 246196 65.9 65.9 23% 2e-10 32.79 349 A0R4S6.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Mycobacteriu... NA 362242 65.5 65.5 23% 3e-10 31.09 347 A0PUX2.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Mycobacteriu... NA 216594 65.5 65.5 23% 3e-10 31.09 347 B2HI25.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Marinomonas ... NA 400668 64.7 64.7 16% 4e-10 39.51 339 A6W1X1.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Mycolicibact... NA 350058 64.3 64.3 23% 6e-10 32.23 350 A1TFQ5.1 RecName: Full=Homocitrate synthase, omega subunit [Clostridium... Clostridium ... NA 1501 64.3 64.3 32% 7e-10 25.45 352 Q00852.1 RecName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName:... Mycobacteriu... NA 410289 63.9 63.9 23% 7e-10 31.09 346 A1KPL9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Salinispora ... NA 391037 63.9 63.9 16% 9e-10 38.55 348 A8M6W8.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Mycobacteriu... NA 164757 63.9 63.9 23% 9e-10 32.23 353 A3Q6M9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Mycobacteriu... NA 243243 63.5 63.5 23% 1e-09 32.23 352 A0QAG9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Mycobacteriu... NA 262316 63.5 63.5 23% 1e-09 32.23 352 Q743Q8.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Mycobacteriu... NA 164757 63.5 63.5 23% 1e-09 32.23 363 A3Q4B9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 5; Short=HOA 5;... Dechloromona... NA 159087 63.5 63.5 19% 1e-09 32.67 354 Q479E5.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Mycobacteriu... NA 189918 63.5 63.5 23% 1e-09 32.23 353 A1UM80.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Alkalilimnic... NA 187272 63.2 63.2 16% 2e-09 37.04 342 Q0A5T5.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Thermus ther... NA 300852 62.4 62.4 23% 2e-09 25.83 347 Q53WI0.1 RecName: Full=Oxaloacetate decarboxylase; Short=OAA... Mycobacteriu... NA 83332 62.4 62.4 25% 2e-09 29.69 336 O06334.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Shewanella p... NA 398579 62.0 62.0 19% 3e-09 34.00 340 A8H4E9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Stutzerimona... NA 316 62.0 62.0 16% 3e-09 38.27 346 Q9ZI56.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bordetella p... NA 340100 62.8 62.8 58% 4e-09 25.47 568 A9HW07.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Pseudomonas ... NA 303 61.6 61.6 16% 4e-09 38.27 346 P51017.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Burkholderia... NA 320372 60.8 60.8 24% 8e-09 32.52 347 Q3JK55.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Burkholderia... NA 272560 60.8 60.8 24% 8e-09 32.52 347 Q63JB1.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Shewanella h... NA 458817 60.8 60.8 16% 8e-09 38.27 340 B0TTS9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Burkholderia... NA 320373 60.8 60.8 24% 8e-09 32.52 347 A3NML2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bifidobacter... NA 391904 61.2 61.2 60% 1e-08 24.10 638 B7GT76.1 RecName: Full=2-isopropylmalate synthase; AltName:... Paraburkhold... NA 266265 60.8 60.8 59% 1e-08 24.48 572 Q13WM0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Paraburkhold... NA 398527 60.8 60.8 59% 1e-08 24.18 572 B2SXZ9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Azotobacter ... NA 322710 59.7 59.7 16% 2e-08 34.94 350 C1DN55.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Mycobacteroi... NA 561007 58.9 58.9 15% 4e-08 42.67 359 B1MH40.1 RecName: Full=2-isopropylmalate synthase; AltName:... Streptospora... NA 479432 59.3 59.3 58% 5e-08 23.40 579 D2ATJ4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Herbaspirill... NA 757424 58.9 58.9 28% 5e-08 28.00 575 D8J0Q1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Clostridium ... NA 272562 58.9 58.9 58% 6e-08 24.70 558 Q97MC5.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Burkholderia... NA 271848 58.2 58.2 19% 7e-08 35.00 347 Q2T7S9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Pseudomonas sp. NA 306 58.2 58.2 63% 7e-08 24.86 343 Q9KWS0.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Azoarcus ole... NA 418699 58.2 58.2 16% 7e-08 33.73 347 A1K6L9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Metapseudomo... NA 1149133 57.8 57.8 16% 9e-08 35.80 347 Q4F8H9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Magnetococcu... NA 156889 58.2 58.2 28% 9e-08 28.21 559 A0LBW3.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Methylibium ... NA 420662 57.4 57.4 26% 1e-07 27.41 358 A2SL35.1 RecName: Full=2-isopropylmalate synthase; AltName:... Parvibaculum... NA 402881 57.0 57.0 31% 2e-07 28.57 563 A7HP03.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Thermomicrob... NA 309801 56.2 56.2 58% 3e-07 21.34 356 B9L2J0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Marinomonas ... NA 400668 56.6 56.6 83% 3e-07 22.87 558 A6VSA9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Pseudomonas ... NA 390235 54.7 54.7 49% 7e-07 25.66 339 B1J6Y1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Nocardia far... NA 247156 55.1 55.1 26% 1e-06 29.20 580 Q5YVA5.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Rhodococcus ... NA 101510 53.9 53.9 51% 1e-06 26.33 346 Q0SJD5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Bacillus pum... NA 315750 54.3 54.3 58% 2e-06 22.74 553 A8FAK7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Streptomyces... NA 227882 53.9 53.9 58% 2e-06 23.26 573 Q82BV3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Azoarcus ole... NA 418699 53.5 53.5 28% 2e-06 28.28 572 A1KBD3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Ralstonia pi... NA 402626 53.5 53.5 61% 3e-06 22.61 570 B2UJY9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 5; Short=HOA 5;... Rhodococcus ... NA 632772 52.8 52.8 23% 3e-06 27.97 352 C1AYB4.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 4; Short=HOA 4;... Rhodococcus ... NA 101510 52.8 52.8 23% 3e-06 27.97 352 Q0S4F8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Renibacteriu... NA 288705 53.1 53.1 59% 4e-06 22.92 582 A9WML8.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Pseudoaltero... NA 326442 52.0 52.0 16% 6e-06 33.33 344 Q3IEQ9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 5; Short=HOA 5;... Rhodococcus ... NA 101510 51.6 51.6 52% 7e-06 25.89 342 Q0S006.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Nocardioides... NA 196162 51.6 51.6 49% 8e-06 25.94 342 A1SIM3.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Xanthobacter... NA 78245 51.2 51.2 48% 1e-05 24.23 344 A7IDU6.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Rhodococcus ... NA 632772 51.2 51.2 16% 1e-05 37.08 340 C1B7L0.1 RecName: Full=2-isopropylmalate synthase; AltName:... Ralstonia ps... NA 267608 51.6 51.6 27% 1e-05 27.21 576 Q8XSZ5.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Serratia pro... NA 399741 50.1 50.1 19% 2e-05 31.68 333 A8GG86.1 RecName: Full=2-isopropylmalate synthase; AltName:... Agrobacteriu... NA 176299 50.1 50.1 83% 4e-05 22.15 558 Q8UD63.2 RecName: Full=2-isopropylmalate synthase; AltName:... Streptomyces... NA 100226 49.7 49.7 26% 4e-05 27.74 573 O31046.2 RecName: Full=2-isopropylmalate synthase; AltName:... Cupriavidus ... NA 977880 49.7 49.7 51% 4e-05 22.66 569 B2AHM5.1 RecName: Full=Isopropyl malate synthase gloH; AltName:... Glarea lozoy... NA 1116229 49.7 49.7 58% 5e-05 21.18 617 S3D9F8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Corynebacter... NA 340322 49.3 49.3 59% 7e-05 22.46 616 A4QAP0.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 6; Short=HOA 6;... Rhodococcus ... NA 632772 48.5 48.5 19% 7e-05 32.69 339 C1BE28.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 7; Short=HOA 7;... Rhodococcus ... NA 101510 48.1 48.1 48% 8e-05 24.62 336 Q0RWN1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Thermobifida... NA 269800 48.1 48.1 60% 1e-04 22.95 568 Q47RM9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Rhodococcus ... NA 234621 47.4 47.4 15% 2e-04 36.14 342 C0ZU50.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Azoarcus ole... NA 418699 47.0 47.0 52% 2e-04 25.36 346 A1K893.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Azoarcus ole... NA 418699 47.0 47.0 52% 2e-04 25.36 342 A1K6Y4.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Mycobacteroi... NA 561007 46.6 46.6 15% 3e-04 37.35 333 B1MJT9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Paenarthroba... NA 290340 47.0 47.0 58% 3e-04 23.33 579 A1R6V4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Catenulispor... NA 479433 47.0 47.0 58% 3e-04 22.02 573 C7QJN7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Kocuria rhiz... NA 378753 47.0 47.0 54% 4e-04 23.57 584 B2GHT7.1 RecName: Full=2-isopropylmalate synthase 2, mitochondrial;... Saccharomyce... NA 559292 46.6 46.6 26% 4e-04 27.74 604 Q12166.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Parafrankia ... NA 298653 46.2 46.2 10% 4e-04 42.31 336 A8LEP8.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Shewanella w... NA 392500 46.2 46.2 19% 4e-04 33.00 339 B1KJK9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Corynebacter... NA 196164 46.6 46.6 26% 4e-04 26.62 581 Q8FU05.1 RecName: Full=2-isopropylmalate synthase; AltName:... Corynebacter... NA 196627 46.6 46.6 59% 4e-04 22.12 616 P42455.1 RecName: Full=2-isopropylmalate synthase; AltName:... Helicobacter... NA 235279 46.6 46.6 61% 5e-04 22.28 558 Q7VH30.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Mycobacteriu... NA 189918 46.2 46.2 51% 5e-04 23.66 349 A1UQA1.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Cupriavidus ... NA 266264 45.8 45.8 23% 5e-04 26.67 348 Q1LNS4.1 RecName: Full=2-isopropylmalate synthase; AltName:... Azotobacter ... NA 322710 46.2 46.2 59% 6e-04 21.41 557 C1DE40.1 RecName: Full=Pyruvate carboxylase 1; AltName: Full=Pyruvic... Caenorhabdit... NA 6239 46.2 46.2 28% 6e-04 26.49 1175 O17732.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Methylocella... NA 395965 45.4 45.4 54% 7e-04 25.00 346 B8ESV2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Brucella sui... NA 204722 45.8 45.8 20% 8e-04 28.04 555 Q8FZC4.2 RecName: Full=2-isopropylmalate synthase; AltName:... Mycobacteriu... NA 272631 45.8 45.8 26% 8e-04 26.28 607 Q9CB76.1 RecName: Full=2-isopropylmalate synthase; AltName:... Stutzerimona... NA 379731 45.4 45.4 60% 0.001 21.74 556 A4VNV6.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Acidovorax s... NA 232721 45.1 45.1 18% 0.001 34.78 342 A1W2K3.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Ralstonia pi... NA 402626 45.1 45.1 22% 0.001 28.57 348 B2UJF1.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Burkholderia... NA 269482 44.7 44.7 23% 0.001 26.67 348 A4JW25.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 223283 45.1 45.1 28% 0.001 25.32 556 Q886Y1.2 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Comamonas te... NA 285 44.7 44.7 16% 0.001 34.57 350 Q83VZ3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Schizosaccha... NA 284812 44.7 44.7 58% 0.002 21.98 584 O59736.2 RecName: Full=2-isopropylmalate synthase; AltName:... Rhodospirill... NA 269796 44.7 44.7 26% 0.002 28.97 558 Q2RT17.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 220664 44.7 44.7 28% 0.002 25.32 559 Q4K6V7.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Verminephrob... NA 391735 44.3 44.3 16% 0.002 38.27 344 A1WLL2.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Comamonas te... NA 285 44.3 44.3 16% 0.002 34.57 345 Q9RHN1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 205922 44.3 44.3 29% 0.002 24.54 559 Q3K7C3.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Nocardioides... NA 196162 43.9 43.9 15% 0.002 33.73 339 A1SH77.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Cupriavidus ... NA 977880 43.9 43.9 19% 0.002 31.00 341 B2AIJ5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Clavibacter ... NA 31964 44.3 44.3 58% 0.002 21.67 588 B0RCQ8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Mesorhizobiu... NA 266835 44.3 44.3 22% 0.002 26.40 558 Q98HN3.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 390235 44.3 44.3 29% 0.002 24.54 557 B1JDI2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 205918 44.3 44.3 28% 0.002 25.32 556 Q4ZX14.1 RecName: Full=2-isopropylmalate synthase; AltName:... Parafrankia ... NA 298653 44.3 44.3 23% 0.002 27.78 565 A8L551.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 384676 44.3 44.3 59% 0.002 20.78 557 Q1I5K2.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Burkholderia... NA 216591 43.9 43.9 49% 0.002 24.53 347 B4EFI7.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Cupriavidus ... NA 381666 43.5 43.5 16% 0.003 35.80 341 Q0K3N2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 216595 43.9 43.9 29% 0.003 23.93 559 C3K1K7.1 RecName: Full=2-isopropylmalate synthase; AltName:... Saccharomyce... NA 559292 43.9 43.9 26% 0.003 27.01 619 P06208.1 RecName: Full=2-isopropylmalate synthase; AltName:... Ectopseudomo... NA 399739 43.9 43.9 59% 0.003 21.45 556 A4XY24.1 RecName: Full=2-isopropylmalate synthase; AltName:... Brucella mel... NA 224914 43.9 43.9 20% 0.003 28.04 555 Q8YIJ3.2 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Burkholderia... NA 482957 43.5 43.5 19% 0.003 32.04 348 Q390P6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Mycobacteriu... NA 362242 43.5 43.5 26% 0.003 26.24 566 A0PVE6.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Mycolicibact... NA 246196 43.1 43.1 48% 0.004 25.29 346 A0QZU2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Clavibacter ... NA 443906 43.1 43.1 58% 0.005 21.05 588 A5CRB9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 4; Short=HOA 4;... Dechloromona... NA 159087 42.7 42.7 16% 0.005 37.35 343 Q479H0.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2;... Dechloromona... NA 159087 42.7 42.7 16% 0.005 37.35 341 Q47GC6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Arthrobacter... NA 290399 43.1 43.1 26% 0.005 27.34 579 A0JX36.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudarthrob... NA 452863 42.7 42.7 26% 0.006 27.34 579 B8H8Q9.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 208964 42.7 42.7 26% 0.007 24.82 556 Q9HXK5.2 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 264730 42.7 42.7 28% 0.007 24.68 556 Q48LY5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 381754 42.7 42.7 28% 0.007 23.97 556 A6V0X2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Leifsonia xy... NA 281090 42.4 42.4 26% 0.009 26.62 590 Q6AED3.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3;... Paraburkhold... NA 266265 42.0 42.0 48% 0.009 23.31 338 Q13QH6.1 RecName: Full=2-isopropylmalate synthase; AltName:... Sinorhizobiu... NA 266834 42.0 42.0 26% 0.011 25.17 558 Q9X7L2.3 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Leptothrix c... NA 395495 41.6 41.6 20% 0.011 29.09 345 B1Y2E5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 160488 42.0 42.0 29% 0.011 24.07 557 Q88P28.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 351746 42.0 42.0 29% 0.012 24.07 557 A5VZB6.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Dechloromona... NA 159087 41.6 41.6 16% 0.013 35.80 343 Q47HL8.1 RecName: Full=2-isopropylmalate synthase; AltName:... Hydrogenovib... NA 317025 41.6 41.6 29% 0.013 24.39 539 Q31EF5.1 RecName: Full=2-isopropylmalate synthase; AltName:... Mycobacteriu... NA 83331 42.0 42.0 26% 0.014 25.55 644 P9WQB2.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 4; Short=HOA 4;... Paraburkhold... NA 266265 41.2 41.2 16% 0.015 33.73 346 P51015.2 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Methylibium ... NA 420662 41.2 41.2 19% 0.016 29.41 349 A2SI33.1 RecName: Full=2-isopropylmalate synthase; AltName:... Kineococcus ... NA 266940 41.6 41.6 26% 0.016 26.28 575 A6WDF2.1 RecName: Full=2-isopropylmalate synthase; AltName:... Pseudomonas ... NA 76869 41.2 41.2 28% 0.018 23.81 557 B0KRD9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1;... Burkholderia... NA 482957 40.8 40.8 49% 0.019 24.33 355 Q397Q9.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Polaromonas ... NA 365044 40.8 40.8 16% 0.022 33.33 346 A1VUV1.1 RecName: Full=2-isopropylmalate synthase; AltName:... Mycobacteriu... NA 233413 41.2 41.2 21% 0.022 30.00 701 Q7TVV6.1 RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA;... Rhodoferax f... NA 338969 39.7 39.7 16% 0.047 32.10 342 Q221U7.1 Alignments: >RecName: Full=(R)-citramalate synthase CimA; AltName: Full=LiCMS [Leptospira interrogans serovar Lai str. 56601] Sequence ID: Q8F3Q1.1 Length: 516 Range 1: 1 to 516 Score:1053 bits(2722), Expect:0.0, Method:Compositional matrix adjust., Identities:516/516(100%), Positives:516/516(100%), Gaps:0/516(0%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE Sbjct 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 TVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP Sbjct 61 TVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 Query 121 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL Sbjct 121 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 Query 181 GVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 GVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER Sbjct 181 GVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 Query 241 AGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 AGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG Sbjct 241 AGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 Query 301 VHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLER 360 VHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLER Sbjct 301 VHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLER 360 Query 361 VIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIH 420 VIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIH Sbjct 361 VIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIH 420 Query 421 KEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDL 480 KEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDL Sbjct 421 KEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDL 480 Query 481 EEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 EEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI Sbjct 481 EEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methanopyrus kandleri AV19] Sequence ID: Q8TYB1.1 Length: 499 Range 1: 4 to 495 Score:239 bits(610), Expect:1e-71, Method:Compositional matrix adjust., Identities:166/510(33%), Positives:266/510(52%), Gaps:22/510(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQT GVS + EK+ IA+ L + VD +E S+GE E V+ I Sbjct 4 RVRIFDTTLRDGEQTPGVSLTVEEKVEIAR-KLDEFGVDTIEAGFPVASEGEFEAVRAI- 61 Query 67 EWAATEQLTERIEILGFVDGNK-TVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 A E+L EI G K +D D+ +++ S HL +L + +E Sbjct 62 ---AGEELD--AEICGLARCVKGDIDAAIDADVDCVHVFIATSDIHLRYKLEMSREEALE 116 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 +EYA G+ + ED + R DY+ + + + +R+ +PDT+GV++P Sbjct 117 RAIEGVEYASDHGVTVEFSAEDAT---RTDRDYLLEVYKATVEAGADRVNVPDTVGVMTP 173 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 E ++ ++ D+ H HND+ ++VANSL A+ AG + +H ++NG+GERAGN Sbjct 174 PEMYRLTAEVVDAV-DVPVSVHCHNDFGMAVANSLAAVEAGAEQVHVTVNGIGERAGNAS 232 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 LE +V + + + ++ + E SRLVE +G + N PIVGE+ F +G+H+ G Sbjct 233 LEQVVMALKALYDIELDVRTEMLVELSRLVERLTGVVVPPNTPIVGENAFAHESGIHSHG 292 Query 306 D-KKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 KK Y PI PE G +R LGK AG+ +I + ++++G+ ++E L +++ RV EL Sbjct 293 VIKKAETY-EPIRPEDVGHRRRIVLGKHAGRHAIKKKLEEMGIEVTEEQLDEIVRRVKEL 351 Query 365 GDQNKLVTPEDLPFIIADVSGRT--GEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKE 422 GD+ K VT +DL I DV G E + ++ + +G P A + + G+ H+ Sbjct 352 GDKGKRVTEDDLEAIARDVVGEVPESEAAVKLEEIAVMTGNKFTPTASVRVYLDGEEHEA 411 Query 423 ISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEE 482 S G G DA + AL + LG+ + +L +Y + GG TDAL E + L+ E+ Sbjct 412 ASTGVGSVDAAIRALREAIEELGMDV-ELKEYRLEAITGG-TDALAEVTV----RLEDED 465 Query 483 DQTFKTMGVHPDQTVAAVHATEKMLNQILQ 512 G D +A+V A + +N++ + Sbjct 466 GNVTTARGAAEDIVMASVKAFVRGVNRLAR 495 >RecName: Full=Putative (R)-citramalate synthase CimA [Methanothermobacter thermautotrophicus str. Delta H] Sequence ID: O26819.1 Length: 496 Range 1: 2 to 487 Score:238 bits(608), Expect:2e-71, Method:Compositional matrix adjust., Identities:173/508(34%), Positives:259/508(50%), Gaps:25/508(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ +LD TLRDGEQT GVS + EKL IA + L D +E SA S+GE E ++KI Sbjct 2 QVRVLDTTLRDGEQTPGVSLTPEEKLRIA-LKIDALGADIIEAGSAITSEGEREGIRKI- 59 Query 67 EWAATEQLTERIEILGFVDG-NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 +E L R EI F + +D ++L+ S HLE +L KT +E Sbjct 60 ---TSEGL--RAEICSFARAVREDIDAAISCDVDSVHLVVPTSDLHLEHKLRKTREEVLE 114 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 EYA+ G+ + + ED + R+ D+++++ + ERI DT+G+L+P Sbjct 115 QAVDCTEYAVDHGILVELSAEDST---RSDMDFLRTIFREGIEAGAERICACDTVGILTP 171 Query 186 EETFQGVDSLIQ-KYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 E +++ L + P H HND+ L+VANSL +RAG +HA+ING+GERAGN Sbjct 172 ERSYEFYRGLSELGAP---LSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAGNA 228 Query 245 PLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 LE +V + + T+IN + E SR+V +G + N+ IVGE+ F +G+HAD Sbjct 229 ALEEVVVALKSLYDVDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIHAD 288 Query 305 GD-KKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIE 363 G KK Y PI PE G R + +GK G ++ + + +LGM +++ L ++ RV Sbjct 289 GVLKKAETY-EPITPEMVGHGRGFVMGKHIGTHALRKRLDELGMKVADDKLMEIFRRVKT 347 Query 364 LGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEI 423 LGD K VT DL I DV G +KV+ ++ I SG + P A ++L + E Sbjct 348 LGDMGKCVTDVDLQAIAEDVLGVMEDKVVDLQEVTIVSGNRVTPTASVKLRVDDREVLEA 407 Query 424 SEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEED 483 G G DA + A+ K + L +Y V GG TDAL++ I D Sbjct 408 GTGVGPVDAAIVAIKKSLEDF--ADITLEEYHVDAITGG-TDALIDVVIKLRHG-----D 459 Query 484 QTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + PD +A+V A +N++L Sbjct 460 RIISARSTQPDIIMASVEAFLSGVNRLL 487 >RecName: Full=Putative (R)-citramalate synthase CimA [Methanopyrus kandleri AV19] Sequence ID: Q8TYM1.1 Length: 509 Range 1: 14 to 463 Score:226 bits(575), Expect:2e-66, Method:Compositional matrix adjust., Identities:156/462(34%), Positives:249/462(53%), Gaps:14/462(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQT GV+ + EKL IA+ L ++ VD +E A S+GEL+ +++I Sbjct 14 VRIFDTTLRDGEQTPGVALTPEEKLRIAR-KLDEIGVDTIEAGFAAASEGELKAIRRI-- 70 Query 68 WAATEQL-TERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A E+L E + V G+ ++ A ++++ S H++K+L +E Sbjct 71 --AREELDAEVCSMARMVKGDVD--AAVEAEADAVHIVVPTSEVHVKKKLRMDREEVLER 126 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 V+EYA GL + + ED G R +Y+ + + + ER+ DT+GV++PE Sbjct 127 AREVVEYARDHGLTVEISTED---GTRTELEYLYEVFDACLEAGAERLGYNDTVGVMAPE 183 Query 187 ETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 F V L ++ D+ H H+D+ ++ AN++ A+RAG + +H ++NG+GERAGN Sbjct 184 GMFLAVKKLRERVGEDVILSVHCHDDFGMATANTVAAVRAGARQVHVTVNGIGERAGNAA 243 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 LE +V + + T I +TE S+LVE +G R+ N+ +VGE+ FT +G+HADG Sbjct 244 LEEVVVVLEELYGVDTGIRTERLTELSKLVERLTGVRVPPNKAVVGENAFTHESGIHADG 303 Query 306 DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELG 365 K PI PE+ G +R + LGK G + I + +KQ+G+ + + L ++L R+ LG Sbjct 304 ILKDESTYEPIPPEKVGHERRFVLGKHVGTSVIRKKLKQMGVDVDDEQLLEILRRLKRLG 363 Query 366 DQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISE 425 D+ K +T DL I DV GR E+ + ++ +G P A I ++ G + S Sbjct 364 DRGKRITEADLRAIAEDVLGRPAERDIEVEDFTTVTGKRTIPTASIVVKIDGTRKEAAST 423 Query 426 GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 G G DA + AL + GI +L++Y GG TDA+ Sbjct 424 GVGPVDATIKALERALKDQGIDF-ELVEYRAEALTGG-TDAI 463 >RecName: Full=(R)-citramalate synthase CimA [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q58787.1 Length: 491 Range 1: 3 to 466 Score:223 bits(567), Expect:2e-65, Method:Compositional matrix adjust., Identities:156/477(33%), Positives:252/477(52%), Gaps:15/477(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQT GVS + ++KL IAK L +L VD +E SA SKGE E ++ I + Sbjct 3 VRIFDTTLRDGEQTPGVSLTPNDKLEIAKKL-DELGVDVIEAGSAITSKGEREGIKLITK 61 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 ++ + L VD + ++ DS ++L+ S H++ +L KT E Sbjct 62 EGLNAEICSFVRALP-VDIDAALECDVDS----VHLVVPTSPIHMKYKLRKTEDEVLETA 116 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 +EYA + GL + + ED + R+ +++ L K +R+ + DT+GVL+P++ Sbjct 117 LKAVEYAKEHGLIVELSAEDAT---RSDVNFLIKLFNEGEKVGADRVCVCDTVGVLTPQK 173 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 + Q + I + ++ H HND+ ++ AN+ A+ G H ++NG+GERAGN LE Sbjct 174 S-QELFKKITENVNLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNASLE 232 Query 248 ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDK 307 +V + T I + E SR+V + N+ IVG++ F AG+H DG Sbjct 233 EVVAALKILYGYDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHVDGLI 292 Query 308 KGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQ 367 K PI PE G +R LGK +G+ ++ + +G+ +S+ L K+ ERV E GD Sbjct 293 KNTETYEPIKPEMVGNRRRIILGKHSGRKALKYKLDLMGINVSDEQLNKIYERVKEFGDL 352 Query 368 NKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK--IHKEISE 425 K ++ DL I+ +V+G+ E+ + + + SG I P A ++L Y+G+ E + Sbjct 353 GKYISDADLLAIVREVTGKLVEEKIKLDELTVVSGNKITPIASVKLHYKGEDITLIETAY 412 Query 426 GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEE 482 G G DA +NA+ K + G++ KL++Y V GG TDAL+E + K ++ E Sbjct 413 GVGPVDAAINAVRKAIS--GVADIKLVEYRVE-AIGGGTDALIEVVVKLRKGTEIVE 466 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q58595.1 Length: 518 Range 1: 23 to 513 Score:220 bits(560), Expect:3e-64, Method:Compositional matrix adjust., Identities:167/512(33%), Positives:256/512(50%), Gaps:28/512(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQT GVS + EK++IA L L VD +E S GE E ++KI Sbjct 23 RVYIFDTTLRDGEQTPGVSLTPEEKIDIA-IKLDDLGVDVIEAGFPVSSLGEQEAIKKIC 81 Query 67 EWAATEQLTERIEILGFVDG-NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 L EI G K +D D G ++ S H + +L K+ +E Sbjct 82 ------SLNLDAEICGLARAVKKDIDVAIDCGVDRIHTFIATSPLHRKYKLKKSKEEIID 135 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 IEY + G+++ ED + R DY+ + + + I +PDT+GV+ P Sbjct 136 IAVDAIEYIKEHGIRVEFSAEDAT---RTEIDYLIEVYKKAVDAGADIINVPDTVGVMIP 192 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 + ++ L +K + H HND+ L+VANSL A+ AG + +H +INGLGER GN Sbjct 193 RAMYYLINEL-KKEIKVPISVHCHNDFGLAVANSLAAVEAGAEQVHCTINGLGERGGNAA 251 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 LE +V ++ KTNI + E S+LV ++ ++ N+ IVGE+ F +G+HA G Sbjct 252 LEEVVMSLMSIYGVKTNIKTQKLYEISQLVSKYTEIKVQPNKAIVGENAFAHESGIHAHG 311 Query 306 DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVV----LQKVLERV 361 L PI PE G+KR LGK G +I +K+LG+ + + + ++++R+ Sbjct 312 VLAHALTYEPIPPELVGQKRKIILGKHTGTHAIEAKLKELGIEVGKDINKDQFDEIVKRI 371 Query 362 IELGDQNKLVTPEDLPFIIADVSGRTGEK--VLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 LGD+ K VT D+ I+ DV G+ +K V+ ++ + +G + P A + L+ + +I Sbjct 372 KALGDKGKRVTDRDVEAIVEDVVGKLAKKDRVVELEQIAVMTGNRVIPTASVALKIEEEI 431 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLD 479 K + G G DA + A+ K +G I KL +Y + GG TDAL E +T Sbjct 432 KKSSAIGVGPVDAAVKAIQK---AIGEKI-KLKEYHINAITGG-TDALAEVIVTLEGY-- 484 Query 480 LEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + T D A+V A +N+IL Sbjct 485 ---GREITTKAASEDIVRASVEAVIDGINKIL 513 >RecName: Full=Putative (R)-citramalate synthase CimA [Archaeoglobus fulgidus DSM 4304] Sequence ID: O29305.1 Length: 489 Range 1: 2 to 489 Score:216 bits(550), Expect:6e-63, Method:Compositional matrix adjust., Identities:162/506(32%), Positives:261/506(51%), Gaps:19/506(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +++ILD TLRDGEQT GVS S +K+ IA+ L L VD +E +A S+G+ + +++I Sbjct 2 QVKILDTTLRDGEQTPGVSLSVEQKVMIAE-ALDNLGVDIIEAGTAIASEGDFQAIKEIS 60 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + ++ I + +D D+GA+ + ++ S H+ + +++ + Sbjct 61 QRGLNAEICSFARI-----KREDIDAAADAGAESIFMVAPSSDIHINAKFPGKDRDYVIE 115 Query 127 VSF-VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 S IEYA + GL + ED S R D+V L + + +RI DT+GVLSP Sbjct 116 KSVEAIEYAKERGLIVEFGAEDAS---RADLDFVIQLFKRAEEAKADRITFADTVGVLSP 172 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 E+ + V + K + H H+D+ L+ AN++ I+AG + H +INGLGERAGN Sbjct 173 EKMEEIVRKIKAKVK-LPLAIHCHDDFGLATANTIFGIKAGAEEFHGTINGLGERAGNAA 231 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 +E +V + KT I + + S+LVE S + N+PIVG++ FT +G+H Sbjct 232 IEEVVIALEYLYGIKTKIKKERLYNTSKLVEKLSRVVVPPNKPIVGDNAFTHESGIHTSA 291 Query 306 DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELG 365 + PI PE GRKR LGK AG+AS+ + +LG + ++++L R+ E+G Sbjct 292 LFRDAKSYEPISPEVVGRKRVIVLGKHAGRASVEAIMNELGYKATPEQMKEILARIKEIG 351 Query 366 DQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISE 425 D+ K VT D+ II V EK + ++ I SG + P A ++L+ G+ E + Sbjct 352 DKGKRVTDADVRTIIETVLQIKREKKVKLEDLAIFSGKNVMPMASVKLKIDGQERIEAAV 411 Query 426 GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQT 485 G G DA +NA+ + + KL+ Y V GG TDALV+ + K +++ Sbjct 412 GLGPVDAAINAIRRAIKEF--ADIKLVSYHVDAITGG-TDALVDVVVQLKK-----DNKI 463 Query 486 FKTMGVHPDQTVAAVHATEKMLNQIL 511 G D +A+V A + +N + Sbjct 464 VTARGARTDIIMASVEAFIEGINMLF 489 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methanothermobacter thermautotrophicus str. Delta H] Sequence ID: O27525.1 Length: 505 Range 1: 16 to 503 Score:216 bits(551), Expect:7e-63, Method:Compositional matrix adjust., Identities:151/506(30%), Positives:242/506(47%), Gaps:19/506(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQT GV+ + EK IA+ L L VD +E S GE+ ++++I+E Sbjct 16 VRIFDTTLRDGEQTPGVALTVEEKTGIAR-KLDALGVDTIEAGFPAASPGEMNSIRRIVE 74 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 + +L + +D D G ++ S H E +L +P E Sbjct 75 LGLEANICGLARVL-----REDIDAAIDCGVDYIHTFIGTSPLHREYKLKMSPDEIIDRA 129 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 F +EYA + GLK+ ED + R DY+ + E I +PDT+GV+ P Sbjct 130 VFGVEYAAEHGLKVEFSAEDAT---RTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRA 186 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 V L ++ + H HND+ L+VANSL A+ AG +HA++NGLGERAGN LE Sbjct 187 MNHLVSRLKEEL-RVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAALE 245 Query 248 ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGD- 306 +V + + + +I + + S V +G R+ N+ IVGE+ F AG+H G Sbjct 246 EVVMALITRYDLPVDIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAHEAGIHVHGVL 305 Query 307 KKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGD 366 +K Y PI PE G KR LGK G ++ +++ G+ + E + E+V LGD Sbjct 306 EKAETY-EPITPEMVGHKRRIVLGKHTGANALRSKLQEYGIEMKEEQFCTLYEQVKRLGD 364 Query 367 QNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEG 426 + K +T DL + + G+ +++ ++ + +G + P A ++L ++ G Sbjct 365 KGKRITDADLRAMAVTILGKASREIVKLEGIAVMTGESVMPTATVKLRIGDEVKTTSMTG 424 Query 427 DGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTF 486 G DA +NA+ + + + +L +Y + GG T+AL E + + E Sbjct 425 VGPVDAAINAIQSLVSE--TADIELDEYNIEAITGG-TNALAEVFVVMSDG----EGNKA 477 Query 487 KTMGVHPDQTVAAVHATEKMLNQILQ 512 D +A+V A +N+IL Sbjct 478 TGRSTREDIVMASVEAVLDAINKILS 503 >RecName: Full=Putative (R)-citramalate synthase CimA [Methanosphaerula palustris E1-9c] Sequence ID: B8GEI1.1 Length: 500 Range 1: 8 to 489 Score:213 bits(542), Expect:1e-61, Method:Compositional matrix adjust., Identities:163/505(32%), Positives:242/505(47%), Gaps:26/505(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L D TLRDGEQT GVS + +K IA L + VD +E SA S G+ +++I Sbjct 8 KLRFFDTTLRDGEQTPGVSLTPDQKCIIATAL-AAVGVDVIEAGSAAASPGDRAAIRQIA 66 Query 67 EWAATEQLTERIEILGFVDG-NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 +E+ FV +D + G ++L+ S H++K+L K Sbjct 67 NAGLG------VEVCTFVRAMTGDIDAAVECGVDSVHLVVPVSDLHIQKKLRKDRATVAA 120 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNS-PDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 + ++YA + GL + + ED S ++ + S VEH + +R+ DT+G+++ Sbjct 121 MANKAVDYAKERGLIVELSGEDASRADQSFLAEVFASGVEHGA----DRLCFCDTVGLMT 176 Query 185 PEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 PE T + L P H H+D +A ++ A++AG H ++NGLGERAGNT Sbjct 177 PERTALMIPPLAAIAP---LSIHCHDDLGFGLATTIAALKAGASCAHVTVNGLGERAGNT 233 Query 245 PLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 PLE +V + T I + S LV +G + A +PIVGE FT +G+HAD Sbjct 234 PLEEVVMALERLYGYDTRIRTERLYPLSVLVSRLTGVPLPAQKPIVGELAFTHESGIHAD 293 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 G K P+ PE GR R LGK +G AS+ +++ G + LQ ++ RV L Sbjct 294 GILKDPSTYEPLAPETVGRTRRIILGKHSGSASVEAALQESGYRPTPAQLQVIVARVKHL 353 Query 365 GDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEIS 424 GDQ VT DL I V + E VL +K + SG G+ P A + L G + Sbjct 354 GDQGHRVTDGDLAAIAEAVLEVSTEPVLVLKQFTVVSGSGVLPTASVTLLVNGAEVTNAA 413 Query 425 EGDGGYDAFMNALTK-ITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEED 483 G G DA + AL + + + IS L++Y V GG TDALVE T + + Sbjct 414 TGTGPVDAAIEALRRSVADVAAIS---LLEYHVDAITGG-TDALVEVTATLSNG-----E 464 Query 484 QTFKTMGVHPDQTVAAVHATEKMLN 508 T + G D A+V A + +N Sbjct 465 MTRTSRGAETDIIAASVEAVVQGMN 489 >RecName: Full=Putative (R)-citramalate synthase CimA [Methanosarcina acetivorans C2A] Sequence ID: Q8TJJ1.1 Length: 483 Range 1: 1 to 481 Score:211 bits(536), Expect:5e-61, Method:Compositional matrix adjust., Identities:155/501(31%), Positives:252/501(50%), Gaps:23/501(4%) Query 15 LRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQL 74 +RDGEQT GV+ + +KL IA+ L ++ ++ +E SA S GE E+++ + ++ Sbjct 1 MRDGEQTPGVALTREKKLLIARAL-DEMRINVIEAGSAITSAGERESIKAVANAGLDAEI 59 Query 75 TERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSFVIEYA 134 I+ VD + ++L+ S H++ ++ K + V EYA Sbjct 60 CSYCRIVKM-----DVDHALECDVDSIHLVAPVSDLHIKTKIKKDRDTVRQIAAEVTEYA 114 Query 135 IKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEET---FQG 191 GL + + ED S R P+++K++ +R+ DT+G+L PE+T F+ Sbjct 115 KDHGLIVELSGEDAS---RADPEFLKAIYSDGIDAGADRLCFCDTVGLLVPEKTTEIFRD 171 Query 192 VDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVT 251 + S + K P H HND+ L+ AN++ A+ AG K H +INGLGERAGN LE +V Sbjct 172 LSSSL-KAP---ISIHCHNDFGLATANTVAALAAGAKQSHVTINGLGERAGNASLEEVVM 227 Query 252 TIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNL 311 ++ T I I SRLV +G +S N+ +VG + FT AG+H G Sbjct 228 SLEWLYKYDTGIKHEQIYRTSRLVSRLTGIPVSPNKALVGGNAFTHEAGIHVHGLLADKS 287 Query 312 YANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLV 371 P+ PE GR+R LGK AG++SI+ +K++G+ E +++ RV ++GDQ K + Sbjct 288 TYEPMSPEYIGRQRQIVLGKHAGRSSITLALKEMGLEADEAQTEEIFNRVKQMGDQGKHI 347 Query 372 TPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYD 431 T DL I V E ++ ++ I SG + P A I+L + K + G+G D Sbjct 348 TDADLQTIAETVLDIYKEPIVKLEEFTIVSGNRVTPTASIKLNVKDKEIVQAGIGNGPVD 407 Query 432 AFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGV 491 A +NA+ + + + L +Y V GG TDALVE R+ +K+ + G Sbjct 408 AVINAIRRAVSSCAEDVV-LEEYHVDSITGG-TDALVEVRVKLSKN-----GKVITASGA 460 Query 492 HPDQTVAAVHATEKMLNQILQ 512 D +A+V A +N++++ Sbjct 461 RTDIIMASVEAVMNGMNRLIR 481 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Archaeoglobus fulgidus DSM 4304] Sequence ID: O30020.1 Length: 503 Range 1: 1 to 497 Score:211 bits(538), Expect:5e-61, Method:Compositional matrix adjust., Identities:159/520(31%), Positives:268/520(51%), Gaps:31/520(5%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+ V T + + D TLRDGEQ GVS K+ IAK L KL VD +E +KGE E Sbjct 1 MSAVMTTIRVFDTTLRDGEQMPGVSLPLEYKIRIAK-QLDKLGVDVIEAGFPSATKGEFE 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNKT-VDWIKDSGAKVLNLLTKGSLHHLEKQLGKT 119 +V++I L+ EI G K +D ++ ++++ S +E + + Sbjct 60 SVKEI------SSLSLNAEICGLARIVKEDIDAAINANVDMVHIFVPTSRIQIEHTVKMS 113 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 +E +EY G+K D + R +Y+K + + + ++ + +PDT Sbjct 114 KEEIIEKSVECVEYIKSHGVKCMFSAMDAT---RTEVEYLKQIFKAVENAKVDIVNVPDT 170 Query 180 LGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 +GV +P + ++ + L +++ + + H HND+ L+VAN+ A+ AG + ++NG+GE Sbjct 171 VGVATPFKFYELIKQL-REHLKVPIDVHCHNDFGLAVANTYAAVMAGANEVQVTVNGIGE 229 Query 240 RAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 RAGN L +V +H KTNI + E S+LVE +G ++ N PIVGE+ F+ + Sbjct 230 RAGNADLAQVVMILHAIEGIKTNIKTEHLFETSKLVERLTGVKMPPNHPIVGENAFSHES 289 Query 300 GVHADGDKKGNLYANP--ILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 G+HA G K P + PE G KR +GK AG+ I + +++ G L + L ++ Sbjct 290 GIHAHGVLKEYSTFEPGVVTPEMVGHKRRIVIGKHAGRYQIKKILEEAGYHLDDEKLNQI 349 Query 358 LERVIELGDQNKLVTPEDLPFIIADV---SGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 E+V E+GD+ K VT DL F IA+V + EK + + + +G I P A + E Sbjct 350 FEKVKEMGDKGKRVTDLDL-FAIAEVVIGELKREEKAILVDEVTVLTGNKITPTAVLNAE 408 Query 415 YQGKIHKEISE--GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G H++++ G G DA + A+T + +G SI ++ ++ + GG +DAL E + Sbjct 409 VFG--HRKVTSAIGVGPVDASLKAVTSL---VGESI-RITEFRMDAITGG-SDALAEVYV 461 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQ 512 T ++ +E +F + G D +A++ A +N +L+ Sbjct 462 T----VEDDEGHSFTSRGAAQDIVMASIDAVINAVNYLLR 497 >RecName: Full=Putative (R)-citramalate synthase CimA [Methanoculleus marisnigri JR1] Sequence ID: A3CUF2.1 Length: 503 Range 1: 9 to 492 Score:206 bits(523), Expect:7e-59, Method:Compositional matrix adjust., Identities:153/505(30%), Positives:245/505(48%), Gaps:21/505(4%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + D TLRDGEQT GVS + + KL IA L + V +E SA S GE E+++ I + Sbjct 9 IRFFDTTLRDGEQTPGVSLTPAGKLEIATHL-ADVGVHVIEAGSAAASVGERESIRAIAD 67 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 + + L +D D+GA ++L+ S H+ K+L KT ++ Sbjct 68 AGLAAECCTYVRAL-----PGDIDLAADAGADSVHLVVPVSDLHIAKKLRKTREQVSEMA 122 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 +EYA + GL + + ED S R D++ + + +R+ DT+G+L+PE Sbjct 123 WSAVEYAKERGLVVELSGEDAS---RADQDFLAEVFREGVERGADRLCFCDTVGLLTPER 179 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 + L+ IH H+D +A ++ A+RAG H ++NGLGERAGNT LE Sbjct 180 AAAIIPPLLFAPLSIHC----HDDLGFGLATTVAALRAGATCAHVTVNGLGERAGNTSLE 235 Query 248 ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDK 307 LV + T I + S V +G ++ N+PIVGE FT +G+HA G Sbjct 236 ELVMALEVLYGVDTGIATEELYPLSTHVARLTGVPLATNKPIVGEMAFTHESGIHAHGVM 295 Query 308 KGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQ 367 + P+ PER GR+R LGK +G A++ + +G S L+++++R+ LGD Sbjct 296 RDASTYEPLQPERVGRRRRIVLGKHSGSAAVEAALHDMGYAPSAAQLKEIVDRIKRLGDA 355 Query 368 NKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGD 427 +T D+ I V + ++ I SG P A + + +G+ + G Sbjct 356 GMRITDADIMAIADTVMEIEFTPCIELRQFTIVSGSNAIPTASVTMLVRGEEITGAAVGT 415 Query 428 GGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFK 487 G DA + AL + +G S+ +L +Y V GG TDALV+ + +K + +T Sbjct 416 GPVDAAIRALQRSVADVG-SV-RLDEYSVDAITGG-TDALVDVSVKLSK-----DGKTVT 467 Query 488 TMGVHPDQTVAAVHATEKMLNQILQ 512 + G D +A+V A +N++L+ Sbjct 468 SRGARTDIIMASVEAVIAGMNRLLR 492 >RecName: Full=Putative (R)-citramalate synthase CimA [Methanosarcina mazei Go1] Sequence ID: P58966.1 Length: 483 Range 1: 1 to 481 Score:200 bits(509), Expect:4e-57, Method:Compositional matrix adjust., Identities:159/504(32%), Positives:255/504(50%), Gaps:29/504(5%) Query 15 LRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQL 74 +RDGEQT GV+ + +KL IA+ L ++ ++ +E SA S GE E+V+ + + ++ Sbjct 1 MRDGEQTPGVALTKEKKLLIARAL-DEMKINVIEAGSAITSAGERESVRAVANAGLSAEI 59 Query 75 TERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGK---TPKEFFTDVSFVI 131 I+ VD + ++L+ S H+ ++ K T ++ DV+ Sbjct 60 CSYCRIV-----KTDVDHALECDVDSIHLVVPVSDLHIRTKIKKDRDTVRQIAADVT--- 111 Query 132 EYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEET--- 188 EYA + GL + + ED S R ++K++ +R+ DT+G+L PE+T Sbjct 112 EYAKEHGLIVELSGEDSS---RADLGFLKAVYSDGIDAGADRLCFCDTVGLLVPEKTTEI 168 Query 189 FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEA 248 F+ + S + K P H HND+ L+ AN++ A+ AG K H +INGLGERAGN LE Sbjct 169 FRDLSSSL-KAP---ISIHCHNDFGLATANTVAALAAGAKQAHVTINGLGERAGNASLEE 224 Query 249 LVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKK 308 +V + T I I SRLV +G +S N+ +VG + FT AG+H G Sbjct 225 VVMCLEWLYKYDTGIKHEQIYRTSRLVSRLTGIPVSPNKALVGGNAFTHEAGIHVHGLLA 284 Query 309 GNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQN 368 P+ PE GR+R LGK AG++SI+ +K++G+ + +++ RV ++GDQ Sbjct 285 DKATYEPMSPEYIGRQRQIVLGKHAGRSSITLALKEMGLEADDAQTEEIFNRVKQMGDQG 344 Query 369 KLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDG 428 K VT DL I V E ++ ++ I SG + P A I+L + K + G+G Sbjct 345 KHVTDADLQIIAETVLDIYKEPLVKLEEFTIVSGNRVTPTASIKLNVKDKEIVQAGIGNG 404 Query 429 GYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKT 488 DA +NA+ + + + L +Y V GG TDALVE R+ +K E ++ Sbjct 405 PVDAVINAIRRAVSSCAEDVI-LEEYHVDAVTGG-TDALVEVRVKLSK-----EGKSITA 457 Query 489 MGVHPDQTVAAVHATEKMLNQILQ 512 G D +A+V A LN++++ Sbjct 458 SGARTDIIMASVEAVMNGLNRLVR 481 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Ignicoccus hospitalis KIN4/I] Sequence ID: A8AB61.1 Length: 399 Range 1: 20 to 386 Score:197 bits(501), Expect:7e-57, Method:Compositional matrix adjust., Identities:131/377(35%), Positives:194/377(51%), Gaps:11/377(2%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQT G+SF+ +KL IA+ L KL V +E VS+GE E V+ I Sbjct 20 VRIFDTTLRDGEQTPGISFTKEQKLMIAR-QLAKLGVASIEAGFPAVSQGEFEAVKAI-- 76 Query 68 WAATEQLTERIEILGFVDGNKT-VDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A E L EI+ NK +D D+ +++ S HL+ +L T +E Sbjct 77 --AREGLGP--EIVALARANKRDIDKALDADVDAIHVFIAASDIHLKYKLRMTREEALRR 132 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 +EYA G+ + ED G R +Y+ ++VE + +R+ +PDT+GV++P Sbjct 133 AVEAVEYAKSHGVTVEFSPED---GTRADLNYLYTMVEAVVDAGADRVDIPDTVGVMTPT 189 Query 187 ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + ++ H HND+ L+VANS+ I AG + H ++NG+GERAGN L Sbjct 190 RMKYLIKFILPAAKGRIVSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIGERAGNAAL 249 Query 247 EALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGD 306 E +V + N +T +N + E S LV +G I N+PIVGE+VF+ +G+H G Sbjct 250 EEVVAALEFLLNVRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHESGIHVHGV 309 Query 307 KKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGD 366 PI PE G++R LGK +G+ + +K LG V+ +VL+ V LGD Sbjct 310 INNPFTYEPIQPEMVGQRRRIVLGKHSGRHGVEYALKTLGYPTDPDVVLRVLDEVKRLGD 369 Query 367 QNKLVTPEDLPFIIADV 383 VT + L I+ V Sbjct 370 MGIRVTEDKLREIVEKV 386 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Gloeothece citriformis PCC 7424] Sequence ID: B7KJX8.1 Length: 536 Range 1: 1 to 516 Score:200 bits(509), Expect:1e-56, Method:Compositional matrix adjust., Identities:163/535(30%), Positives:249/535(46%), Gaps:44/535(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+ R+ I D TLRDGEQ+ G + + EKL +A+ L +L VD +E S G+ E Sbjct 1 MSNQPNRIIIFDTTLRDGEQSPGATLNGDEKLTVAR-ALARLGVDVIEAGFPYASPGDFE 59 Query 61 TVQKIMEWAATEQLTERIEILGFV-----DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I + E I G D K + +K + ++ S HL + Sbjct 60 AVQQIAKVVGVEGGPS---ICGLARATKADIAKAAEALKPAAKPRIHTFLATSDIHLAYK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L KT +E V ++ YA + ED R+ P+++ ++E + Sbjct 117 LKKTRQEVLEIVPEMVAYAKSFVDDVEFSPEDAG---RSDPEFLYQVLERAIAAGATTVN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G L+P E Q + + + P+I HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGYLTPSEFGQLIRGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV +H D + TNIN I + SRLV Sbjct 234 TINGIGERAGNAALEELVMALHVRRQYYNPFLGRPVDSTEPLTNINTKEIYKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L + E G LGKL+G+ + Sbjct 294 TGMAVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRHA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 S +K+LG LSE L K R E+ D+ K +T DL I+ D + E V ++ Sbjct 354 FSTRLKELGFELSETDLNKAFLRFKEVADKKKEITDWDLEAIVNDEIQQAPE-VFRLELV 412 Query 398 NIHSGIGIRPHAQIELE-YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYE 455 + G RP A + L +G+ + + G G DA A+ ++ N +P +LI++ Sbjct 413 QVSCGDQARPTATVILRGPEGQELMDAAIGTGPVDAVYKAINRVVN-----VPNQLIEFS 467 Query 456 VRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 V+ G DA+ E I E++ F + D VA+ A LN++ Sbjct 468 VKSVTAG-IDAMGEVTIRLKY-----ENRIFSGHAANTDIIVASARAYISALNRL 516 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methanosarcina mazei Go1] Sequence ID: P58968.1 Length: 516 Range 1: 19 to 507 Score:194 bits(493), Expect:2e-54, Method:Compositional matrix adjust., Identities:142/509(28%), Positives:255/509(50%), Gaps:27/509(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ + D TLRDGEQT GVS ++++KL IA L KL VD +E S+G+ E+V+ I Sbjct 19 KVTVFDTTLRDGEQTPGVSLTSTQKLEIA-HQLDKLGVDIIEAGFPISSEGDKESVKSIS 77 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + +L K +D +S +++ S + K+ +E Sbjct 78 NAGLDTTVCGLARVL-----KKDIDACFESDVGLVHTFVPTSDVQRIYTIKKSREEVIQL 132 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++Y GLK D + R P+Y+ + + + + + I +PDT+GV+ P Sbjct 133 AVEAVQYIKDHGLKCMFSAMDAT---RTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVPS 189 Query 187 ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 ++ + + + I + H HND+ L+VANSL A+ AG + +ING+GERAGN L Sbjct 190 AMYRQIKGIAAEIT-IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADL 248 Query 247 EALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG- 305 V ++ +KTNI + E S++VE ++G R+ N P+VG++ F+ +G+H+ G Sbjct 249 SQTVMSLTSIYGAKTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFSHESGIHSQGV 308 Query 306 -DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 +K + PE G +R LGK GK ++ ++++ G+ ++ L +++ R+ E+ Sbjct 309 LEKSDTFEPGIMTPEMVGHRRRIVLGKHTGKHAVKQSLESAGIKTNDNQLDEIVIRIKEI 368 Query 365 GDQNKLVTPEDLPFIIADVSGRTG--EKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKE 422 ++ K +T DL + + V G+ E+++ +K ++ +G + P A ++ + +GK Sbjct 369 ANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGKEIIA 428 Query 423 ISEGDGGYDAFMNALTKI---TNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLD 479 G G DA ++A+ I +N +L D+ + GG DAL + I L+ Sbjct 429 ARTGVGPVDAALHAVRDILGESNHF-----RLQDFRIDAITGG-ADALADVYI----GLE 478 Query 480 LEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 E+ + +PD +A+V A +N Sbjct 479 NEKGRIVTARSANPDIVMASVEALVNAMN 507 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Desulforamulus reducens MI-1] Sequence ID: A4J181.1 Length: 505 Range 1: 4 to 505 Score:192 bits(488), Expect:7e-54, Method:Compositional matrix adjust., Identities:156/521(30%), Positives:254/521(48%), Gaps:31/521(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ GVS + +EKL IA+ L +L VD +E S G+ VQ Sbjct 4 RVHIFDTTLRDGEQSPGVSLNLNEKLQIAR-QLARLGVDIIEAGFPITSPGDFAAVQ--- 59 Query 67 EWAATEQLTERIEILGFVDGN-KTVD--W--IKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 A + + + G N K +D W IK++ ++ S HL+ +L K + Sbjct 60 ---AVAREVRGVTVAGLARANFKDIDVAWDAIKEAEQARIHTFIATSDIHLKYKLRKDRE 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + +++A K + ED S R+ DY+ + + + K I +PDT+G Sbjct 117 QVIEAAVAAVKHARKYTSDVEFSAEDAS---RSDIDYLCRIFQEVIKAGATVINVPDTVG 173 Query 182 VLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 +P E Q + +++K P I H H+D L+VANSL A+ AG + + +ING+G Sbjct 174 YTTPGEYAQFIRDILEKTPGMEKIVLSVHCHDDLGLAVANSLAAVGAGARQVEGAINGIG 233 Query 239 ERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 ERAGN LE +V ++ + + T IN I SRLV +G + N+ +VG++ F Sbjct 234 ERAGNAALEEVVMGLYTRKDYYGLMTGINTPEIYRTSRLVSSLTGMPVQPNKSVVGKNAF 293 Query 296 TQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVL 354 +G+H DG K + PE+ G + LGK +G+ + + +++LG L+E L Sbjct 294 AHESGIHQDGVLKERTTYEIMNPEQVGITANNLVLGKHSGRHAFRDRLEELGYHLNEEEL 353 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 R L D+ K +T DL ++ D + + +K +I +G + P A + L+ Sbjct 354 NLAFSRFKVLADKKKEITDHDLQAMVEDEIKHIPDTYV-LKYLHISTGTAVVPTATLGLQ 412 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 ++ +E + GDG DA + KIT GIS L++Y + GGK DAL + + Sbjct 413 MGDELKEEAACGDGPVDAIYKTVDKIT---GISCT-LVNYAINAITGGK-DALGDVTVKI 467 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 E+++ + GV D A+ A +N+++ Q Sbjct 468 RCE---EKEKVYIGRGVSTDILEASAKAYVNAINKLIHDMQ 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rippkaea orientalis PCC 8801] Sequence ID: B7JYP4.1 Length: 536 Range 1: 1 to 521 Score:193 bits(490), Expect:7e-54, Method:Compositional matrix adjust., Identities:161/545(30%), Positives:248/545(45%), Gaps:54/545(9%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+ R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ E Sbjct 1 MSNQPDRIIIFDTTLRDGEQSPGASLTVEEKLTIARSL-ARLGVDIIEAGFPYASPGDFE 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKD--SGAKVLNLLTKGSLH-------- 110 VQKI + TE + I G + KD + A+ + KG +H Sbjct 60 AVQKIAQTVGTE---DGPRICGLARATQ-----KDIQTAAEAVKPAAKGRIHTFLATSDI 111 Query 111 HLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH 170 HL+ +L KT +E V ++ YA + ED R+ P+++ ++E Sbjct 112 HLQYKLKKTRQEVLAIVPDMVAYAKSLVDDVEFSPEDAG---RSDPEFLYQVLERAIAAG 168 Query 171 IERIFLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGV 227 I +PDT+G +P E + + Q P+I HGHND L+VAN L+A++ G Sbjct 169 ATTINIPDTVGYTTPSEFGALIGGIKQNVPNIDQAIISVHGHNDLGLAVANFLEAVKNGA 228 Query 228 KGLHASINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASR 273 + L +ING+GERAGN LE LV +H + + TNIN I SR Sbjct 229 RQLECTINGIGERAGNAALEELVMALHVRRQYFNPFLGRPPESTEPLTNINTKEIYRTSR 288 Query 274 LVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKL 332 LV +G + N+ IVG++ F +G+H DG K L + E G LGKL Sbjct 289 LVSQLTGMMVQPNKAIVGKNAFAHESGIHQDGVLKNKLTYEIMDAESIGLTHNQIVLGKL 348 Query 333 AGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVL 392 +G+ + +K+LG LS+ + R E+ D+ K +T DL I+ D + E + Sbjct 349 SGRNAFRTRLKELGFELSDTEINNAFLRFKEVADKKKEITDWDLAAIVNDEMQQAPE-LF 407 Query 393 TIKSCNIHSGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-K 450 ++ + G P A + L G+ + + G G DA A+ ++ + +P + Sbjct 408 RLELVQVSCGDHACPTATVTLRTPDGQELTDAAIGTGPVDAVYKAINRV-----VQVPNE 462 Query 451 LIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 LI++ V+ G DA+ E I ED+ + + D A+ A LN++ Sbjct 463 LIEFSVKSVTAG-IDAMGEVTIRLRY-----EDKIYSGYAANTDIITASARAYISALNRL 516 Query 511 LQPWQ 515 Q Sbjct 517 YGSIQ 521 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methanosarcina acetivorans C2A] Sequence ID: Q8THA5.1 Length: 515 Range 1: 19 to 507 Score:192 bits(488), Expect:8e-54, Method:Compositional matrix adjust., Identities:142/509(28%), Positives:253/509(49%), Gaps:27/509(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ + D TLRDGEQT GVS ++S+KL I++ L KL VD +E S+G+ E+V+ I Sbjct 19 KVTVFDTTLRDGEQTPGVSLTSSQKLEISR-QLDKLGVDIIEAGFPISSEGDKESVKSIS 77 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + +L K +D +S +++ S + K+ +E Sbjct 78 NAGLETTVCGLARVL-----KKDIDACFESDVGLVHTFVPTSDVQRIYTIKKSQEEVIQL 132 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++Y GLK D + R P Y+ + + + + + I +PDT+GV+ P Sbjct 133 AVEAVQYIKDHGLKCMFSAMDAT---RTDPAYLIEVFKAVQEAGCDIINVPDTVGVMVPS 189 Query 187 ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 ++ + + + I + H HND+ L+VANSL A+ AG + +ING+GERAGN L Sbjct 190 AMYRQIKDIAAEIT-IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADL 248 Query 247 EALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG- 305 V ++ KTNI + E S+++E ++G R+ N P+VG++ F+ +G+H+ G Sbjct 249 AQTVMSLASIYGIKTNIRTEYLVETSKMIENYTGIRLPPNTPVVGQNAFSHESGIHSQGV 308 Query 306 -DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 +K + PE G +R LGK GK ++ ++++ G+ SE L +++ R+ E+ Sbjct 309 LEKSDTFEPGIMTPEMVGHRRRIVLGKHTGKHAVKQSLESAGVKTSENQLDEIVLRIKEI 368 Query 365 GDQNKLVTPEDLPFIIADVSGRTG--EKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKE 422 ++ K +T DL + + V G+ E+++ +K ++ +G + P A ++ + +GK Sbjct 369 ANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGKEIIA 428 Query 423 ISEGDGGYDAFMNALTKI---TNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLD 479 G G DA + A+ I +N +L ++ + GG DAL + I L+ Sbjct 429 AKTGVGPVDAALKAVRDILGESNHF-----RLQEFRIDAITGG-ADALADVYI----GLE 478 Query 480 LEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 E+ + +PD +A+V A +N Sbjct 479 NEKGRIVTARSANPDIVMASVEALINAMN 507 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methylorubrum populi BJ001] Sequence ID: B1ZDN3.1 Length: 520 Range 1: 11 to 505 Score:191 bits(486), Expect:2e-53, Method:Compositional matrix adjust., Identities:155/520(30%), Positives:244/520(46%), Gaps:41/520(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKL +A+ LL + VD +E S G+ E V +I Sbjct 11 RVVIFDTTLRDGEQCPGATMTLDEKLAVAE-LLDAMGVDIIEAGFPIASNGDFEAVSEIA 69 Query 67 EWAATEQLTERIEILGFV-----DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 + T+R I G D + + ++ + A ++ S HL Q+ KT Sbjct 70 ------RRTKRATIAGLARAIPADIARAGEAVRHAKAGRIHTFVSTSAIHLAHQMRKTQD 123 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLP 177 E VIE +K+ + +ED WS + R DY+ VE + I LP Sbjct 124 E-------VIEIILKTVTQARDLVEDVEWSAMDATRTDIDYLCRCVEAAIRSGATTINLP 176 Query 178 DTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G +P+E F+ V + F H HND L+VANSL + G + + ++ Sbjct 177 DTVGYATPQEYGAMFRQVRERVPNSDKAIFSVHCHNDLGLAVANSLAGLEGGARQIECTV 236 Query 235 NGLGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGN LE +V I +++ T I+ +T AS+LV + + N+ IVG Sbjct 237 NGIGERAGNAALEEIVMAIRTRADVMPYDTGIDTTMLTRASKLVSHAANFPVQYNKAIVG 296 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLS 350 + F +G+H DG K + + P G K S +GK +G+A+ + +LG+ LS Sbjct 297 RNAFAHESGIHQDGMLKHSETYEIMTPASVGLSKTSLVMGKHSGRAAFKSKLAELGISLS 356 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + Q V ER +L D+ K V ED+ ++ D T + + S ++ +G A Sbjct 357 DNQFQDVFERFKDLADRKKHVYDEDIEALV-DEKLATAHDRIKLLSLSVIAGTRGPQRAT 415 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 +++E G+ E ++G+G DA NA+ +I + L Y+V G TDA E Sbjct 416 MKIEMDGRTFTEEADGNGPVDAVFNAIHEIVPHDAV----LELYQVHAVTEG-TDAQAEV 470 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +++ G PD VA+ A LN++ Sbjct 471 SVRLKAG-----ERSVTARGADPDTLVASAKAYLSALNKL 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aquifex aeolicus VF5] Sequence ID: O67862.2 Length: 520 Range 1: 4 to 502 Score:190 bits(483), Expect:5e-53, Method:Compositional matrix adjust., Identities:158/526(30%), Positives:253/526(48%), Gaps:48/526(9%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ G S +T EKL +A L KLNVD +E A SKG+ E V +I Sbjct 4 KVYIFDTTLRDGEQAPGFSMTTEEKLQMAH-QLAKLNVDIIEAGFAAASKGDFEAVNRIA 62 Query 67 E-------WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKT 119 + + L IEI ++ + K ++ S H+E +L T Sbjct 63 KEVKGPVICSLARALESDIEI--------AAKALEPAERKRIHTFIATSPIHMEYKLRMT 114 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 P + + + +A + ED + R+ +++ +E K I +PDT Sbjct 115 PDQVLERIKKAVSFARNFTDDVEFSCEDAT---RSEREFLYRAIETAIKHGATVINIPDT 171 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G PEE Q ++ ++ P+I H H+D L+ ANSL A++ G + + +ING Sbjct 172 VGYAIPEEFGQLIEDIMNNVPNIDKVILSVHCHDDLGLATANSLTAVKHGARQVECTING 231 Query 237 LGERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 +GERAGN LE +V + + + T++N I + SRL+ +G + N+ IVG+ Sbjct 232 IGERAGNAALEEVVMALKVRKDFFGDLYTDVNTKEIYKTSRLLCRITGNFVQPNKAIVGD 291 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F +G+H G + + PE G S LGK +G+ ++ +++LG ++ Sbjct 292 NAFAHESGIHQHGVLSHRMTYEIMNPEDVGFPMSRIVLGKHSGRHALKRRLEELGFKFTK 351 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII----ADVSGRTGEKVLTIKSCNIHSGIGIRP 407 L ++ E+ EL D+ K V EDL +I + KVL + + SG + P Sbjct 352 EELDRIFEKFKELADRKKEVYDEDLEALIYQEFMKIEDHEPVKVLHFQ---VQSGDNMIP 408 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTDA 466 A ++LE++G+ + S G+G DA + A+ K LGI PKL+DY ++ + P TDA Sbjct 409 TATVKLEFKGEEREASSTGNGPVDATIKAIQKA---LGIE-PKLLDYSIKALTPN--TDA 462 Query 467 LVETRITWNKSLDLEEDQTFKT-MGVHPDQTVAAVHATEKMLNQIL 511 E R+ LE D + GV D A+V A LN+ + Sbjct 463 QAEARVV------LELDGVKASGRGVDTDIIKASVKAFTDALNRAI 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodopirellula baltica SH 1] Sequence ID: Q7UI51.2 Length: 527 Range 1: 13 to 514 Score:189 bits(480), Expect:1e-52, Method:Compositional matrix adjust., Identities:160/525(30%), Positives:255/525(48%), Gaps:40/525(7%) Query 4 VETR-LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV 62 V TR + I D TLRDGEQ+ G S + +EKL +A L+ L VD +E S G+ E+V Sbjct 13 VATRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVD-LGVDIIEAGFPIASPGDFESV 71 Query 63 QKI---MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKT 119 ++I + A L E D ++ + +K + +++ S H E +L T Sbjct 72 RQIATTIRGATICGLARCAE----KDIDRAWEALKTAPQARIHVFLATSAIHREFKLRMT 127 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIF 175 P E ++E A+ + + +D + R D++ +VE I Sbjct 128 PDE-------IVERAVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTIN 180 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + L + P++ H H+D ++VANSL A+ AG + Sbjct 181 VPDTVGYTTPGEIYDRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIEC 240 Query 233 SINGLGERAGNTPLEALVT---TIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE LV T D + +TNIN + SRLV +G + N+ I Sbjct 241 TINGIGERAGNAALEELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAI 300 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMV 348 VG + F +G+H DG K + PE G K LGK +G+A++++ KQLGM Sbjct 301 VGRNAFAHESGIHQDGMLKERTTYEIMSPEEVGFTKTDLVLGKHSGRAALADRAKQLGMT 360 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPH 408 L+ LQ+V E EL D+ K + D+ ++ T T+ + SG P+ Sbjct 361 LTGEQLQEVFEAFKELADKKKEIYDGDIVALVQQKISETVAPEWTLVDYEVTSGKNQTPN 420 Query 409 AQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 ++ L + I +++++GDG DA A+ KIT GI + D+ VR G+ DA+ Sbjct 421 VRVTLRRDEQDITEQVAQGDGPIDAAFWAVEKIT---GIQV-VCKDFRVRSATLGR-DAI 475 Query 468 VETRITWNKSLDLE-EDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 E +L++E E +T++ GV D + + A +N+I+ Sbjct 476 GEV------NLEVEHEGKTYRGTGVSTDSVESTILAMLNAINRIV 514 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Candidatus Desulforudis audaxviator MP104C] Sequence ID: B1I1Y1.1 Length: 509 Range 1: 4 to 500 Score:188 bits(477), Expect:3e-52, Method:Compositional matrix adjust., Identities:159/523(30%), Positives:247/523(47%), Gaps:44/523(8%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ GVS + EKL IA L+ KLNVD +E S G+ + VQ Sbjct 4 RVYIFDTTLRDGEQSPGVSLNIREKLQIAHQLV-KLNVDVIEAGFPFASPGDFKGVQ--- 59 Query 67 EWAATEQLTERIEILGFVDGNKT-VD--W--IKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 A + + + G N +D W + ++ ++ S HL+ +L + + Sbjct 60 ---AVAREVRGVSVAGLARANAADIDRAWEALCEAEQPRIHTFIATSDIHLQHKL-RMSR 115 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 E V+E A+++ + Y D + FR+ PDY+ ++ + + +P Sbjct 116 EA------VLETAVEAVRRAKGYTSDVEFSAEDAFRSDPDYLCRVLAAVIAAGATTVNIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G P+E + ++ P I H HND L+VANSL A+R G + + ++ Sbjct 170 DTVGYAMPDEFGAFIAYIMDHTPGIENVVVSVHCHNDLGLAVANSLAAVRNGARQVECTV 229 Query 235 NGLGERAGNTPLEALVT---TIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGN LE +V T +K T I I S+LV +G + N+ IVG Sbjct 230 NGIGERAGNAALEEVVMGLFTRREKYGLITGIQCEEIYRTSKLVSTLTGMPVQFNKAIVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLS 350 ++ F +G+H DG K I P G R+ LGK +G+ + + + +LG L Sbjct 290 KNAFLHESGIHQDGVLKERATYEIICPTMVGITRTNLVLGKHSGRHAFRQRLTELGFELH 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 E L + R EL D K +T EDL I+ D + R + ++ SG ++P A Sbjct 350 EEELNRAFVRFKELADSKKQITDEDLEAIL-DETIRQVPATYELDYLHVFSGTTVKPTAV 408 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 I L G+ +E + G+G DA A+ K T R L+ Y + GG TDAL Sbjct 409 IGLLIDGQFVQEAACGNGPVDATYKAIEKATGRK----YSLVSYVIDAVTGG-TDALA-- 461 Query 471 RITWNKSLDLEED--QTFKTMGVHPDQTVAAVHATEKMLNQIL 511 N +L + +D + + GV D A+ A ++N+I+ Sbjct 462 ----NVTLKMRDDDHRVYTGRGVSADVLEASARAYVNIMNKIV 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Clostridium kluyveri DSM 555] Sequence ID: A5MZ76.1 Length: 514 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Clostridium kluyveri NBRC 12016] Sequence ID: B9E371.1 Length: 514 Range 1: 1 to 499 Score:188 bits(477), Expect:3e-52, Method:Compositional matrix adjust., Identities:158/523(30%), Positives:256/523(48%), Gaps:41/523(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 MTK ++ I D TLRDGEQT VS + ++K+ IAK LQKL+VD +E + S G+ E Sbjct 1 MTK---KIYIFDTTLRDGEQTPKVSLNINDKITIAK-QLQKLSVDVIEAGFPKASHGDFE 56 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK---TVDW--IKDSGAKVLNLLTKGSLHHLEKQ 115 V+ I E + I+G +K W +K S +++ S H+E + Sbjct 57 AVKAIAES------IQGPVIVGLARASKEDIDCAWEALKGSLKPRIHIFLATSDIHMEHK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L P+E + ++ YA I ED + R P+++ ++E + + + + Sbjct 111 LKMKPEEVLKRAADMVRYAKGLCPSIEFSPEDAT---RTRPEFLYKVLEAVIEAGADVVN 167 Query 176 LPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E +G+ ++ D H HND L+VANSL AI +G + + Sbjct 168 IPDTVGYTTPVEYGAFIRGIKENVKNIEDAIISVHCHNDLGLAVANSLAAIESGAEQVEC 227 Query 233 SINGLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPI 289 +INGLGERAGN LE +V I D N T+I IT+ S +V +G ++ N+ I Sbjct 228 AINGLGERAGNAALEEIVMAISTRADSFNCHTDIVTEEITKTSSIVSHVTGMQVQGNKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRSY-ALGKLAGKASISENVKQLGMV 348 VG + F +G+H G + PE G K+++ LGK +G+ + E++ ++G Sbjct 288 VGANAFAHESGIHQHGVLNCRETYEIMTPESVGLKKNFIVLGKHSGRHAFVEHLHEMGYK 347 Query 349 -LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRP 407 LS ++ ++ EL D+ K ++ ED+ ++ + E V +K + +G + Sbjct 348 DLSVEKTDEIFKKFKELADKKKHISDEDIESLVKNEIFHVPE-VFKLKYYQVFTGNTVVS 406 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 + +E+E GK E S GDG DA A+ K T GI + L DY ++ GK DA+ Sbjct 407 TSTVEIECNGKKLSEASCGDGPVDATFKAIEKAT---GIDVT-LNDYFIKAVGSGK-DAM 461 Query 468 VETRITWNKSLDLEEDQTFKTMGVHPD----QTVAAVHATEKM 506 E + K E + F G+ D +A ++A K+ Sbjct 462 GEVTVRIEK-----EGKIFSAKGISTDIVEASGIAFINAVNKL 499 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Cupriavidus pinatubonensis JMP134] Sequence ID: Q473V1.1 Length: 513 Range 1: 4 to 501 Score:187 bits(476), Expect:5e-52, Method:Compositional matrix adjust., Identities:151/518(29%), Positives:246/518(47%), Gaps:34/518(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L++L VD +E A S G+ E ++ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTREEKIRIAK-QLERLKVDVIEAGFAASSNGDYEAIRSIA 62 Query 67 EWAATEQLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 Q+ + I N + + +K + + ++ S H+EK+L TP Sbjct 63 ------QVVKDSTICSLARANDKDIARAAEALKPANSFRIHTFIATSALHMEKKLRMTPD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + + + +A + I ED G R+ D++ ++E + E I LPDT+G Sbjct 117 QVYEQARLAVRFARQFTDDIEFSPED---GSRSDMDFLCRVLEGVIAEGATTINLPDTVG 173 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGL 237 PE + S+ ++ P+ + H HND ++VANSL A++ G + + +INGL Sbjct 174 YAVPEGYADLIRSVRERIPNSDKAVWSVHCHNDLGMAVANSLAAVKLGGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGNT LE +V + D N ++ I AS+LV +G + N+ +VG + Sbjct 234 GERAGNTSLEEVVMAVKTRRDYFNLDVGVDTSQIVPASKLVSQITGFVVQPNKAVVGANA 293 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEV 352 F +G+H DG K + E G LGKL+G+ + + +++LG+ L SE Sbjct 294 FAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVELESEA 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 + R EL DQ + ED+ I+++ + + S + S G RPHA++ Sbjct 354 EVNAAFGRFKELADQKAEIFDEDIMAIVSNEAQHDANEHYRFISLSQRSETGERPHARVV 413 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G+ H EG+G DA ++A+ N S +++ Y V GG T+A E + Sbjct 414 FNMDGQEHSGEGEGNGPVDATLHAIESQVN----SGAEMVLYSVNAITGG-TEAQGEVTV 468 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 +K+ + +G PD A+ A LN++ Sbjct 469 RLSKA-----GRIVNGVGTDPDIVAASAKAYLAALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. MIT 9211] Sequence ID: A9BB43.1 Length: 536 Range 1: 1 to 487 Score:188 bits(477), Expect:5e-52, Method:Compositional matrix adjust., Identities:150/500(30%), Positives:234/500(46%), Gaps:37/500(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S+G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDIIEAGFPYASQGDFT 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I E E E I G +K + I + K ++ S HLE + Sbjct 60 AVQRIAEQVGGE---EGPIICGLARASKADIKACGEAIAPAPKKRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L KT +E V ++ YA + ED + R+ PD++ L+E I Sbjct 117 LRKTREEVIQIVPEMVHYAKSFSEDVEFSCEDAA---RSDPDFLYELIELAISAGAGTIN 173 Query 176 LPDTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G ++P E QG+D+ + + HGHND L+VAN L+AI+ G + L Sbjct 174 IPDTVGYITPSEFGELIQGIDANVPNIDEAILSVHGHNDLGLAVANFLEAIKRGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV +H + T I IT+ SRLV Sbjct 234 TINGIGERAGNAALEELVMALHVRRSFYNPFFGRDPESPTPLTAIRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L + + G +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIVDAKTVGLTDNRISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + +++LG L+ L + + +L D+ + +T DL I+++ + + ++ Sbjct 354 VRARLEELGYDLTRDDLNEAFAKFKDLADRKREITDRDLEAIVSEQVMQPDAR-FQLQLV 412 Query 398 NIHSGIGIRPHAQIELEYQ-GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV 456 + G ++P A + L Q G ++ G G DA AL + +LI++ V Sbjct 413 QVSCGTTLKPTATVTLADQDGTEQTAVALGTGPVDAVCKALDSLAGESN----ELIEFSV 468 Query 457 RIPPGGKTDALVETRITWNK 476 + G DAL E I + Sbjct 469 KSVTEG-IDALGEVTIRLRR 487 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Ralstonia pseudosolanacearum GMI1000] Sequence ID: Q8XXP1.1 Length: 513 Range 1: 4 to 438 Score:187 bits(475), Expect:5e-52, Method:Compositional matrix adjust., Identities:136/440(31%), Positives:218/440(49%), Gaps:14/440(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L++L VD +E A S G+ E ++ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAK-QLERLKVDVIEAGFAASSNGDFEAIRAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + ++ + D ++ + +K +G ++ S H+EK+L TP + + Sbjct 63 QSVKDSRICS-LARANDRDISRAAEALKPAGQFRIHTFIATSALHMEKKLRMTPDQVYEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A + I ED G R+ D++ ++E + E I LPDT+G PE Sbjct 122 ARLAVRFARQFTDDIEFSPED---GSRSDMDFLCRVLEGVIAEGATTINLPDTVGYAVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + S+ ++ P+ + H HND ++VANSL A++ G + + +INGLGERAG Sbjct 179 GYAALIRSVRERIPNSDKAIWSVHCHNDLGMAVANSLAAVKLGGARQIECTINGLGERAG 238 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + D N ++ I AS+LV +G + N+ +VG + F + Sbjct 239 NTSLEEVVMAVKTRRDYFNLDVGVDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGIELDSEAELNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 R EL DQ + ED+ I+++ + + S + S G RPHA+I G Sbjct 359 FTRFKELADQKAEIFDEDIVAIVSNEAQHAEGEHFRFVSLSQRSETGERPHARIVFVADG 418 Query 418 KIHKEISEGDGGYDAFMNAL 437 K +EG+G DA +NA+ Sbjct 419 KEVTGEAEGNGPVDATLNAI 438 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Syntrophus aciditrophicus SB] Sequence ID: Q2LWJ3.1 Length: 516 Range 1: 1 to 462 Score:187 bits(475), Expect:6e-52, Method:Compositional matrix adjust., Identities:149/473(32%), Positives:236/473(49%), Gaps:18/473(3%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M E R+ I D TLRDGEQ+ G S + +EKL IA+ L+K+ VD +E S+G+ Sbjct 1 MDSPEKRIYIFDTTLRDGEQSPGSSMNPAEKLRIAR-QLEKMGVDIIEAGFPIASEGDFL 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 +VQ+I + Q+ + D ++ + I+D+ ++ S HL+ QL K+ Sbjct 60 SVQQIAQEIRGAQIAG-LARANNADIDRAWEAIRDAANPRIHTFISSSDIHLKYQLRKSR 118 Query 121 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 ++ + +E A + D + R Y+ +VE + + +PDT+ Sbjct 119 EQVLKEAVAAVERARSYTPNVEFSPMDAT---RTDRGYLCEMVEAVIAAGASTVNIPDTV 175 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G P+E + + L P+I H HND L+VANSL AI G + + +ING+ Sbjct 176 GYAIPQEFGELIAYLRANVPNISQAIISVHCHNDLGLAVANSLSAILNGARQVECTINGI 235 Query 238 GERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGNT +E +V + + + T I +I ++SRL+ +G + N+ IVG + Sbjct 236 GERAGNTAMEEVVMALRTRKDLFGFYTGIKTESIYQSSRLLTQITGVAVQPNKAIVGANA 295 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRKRSY-ALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K + + P+ G S+ LGK +G+ ++SE++K+LG LS+ Sbjct 296 FAHESGIHQDGLIKEKITYEIMTPQSVGISDSHIVLGKHSGRHAVSEHLKKLGFNLSDTE 355 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 L K+ R EL D K V EDL I+ + R +K I N+ SG P A +++ Sbjct 356 LNKIFVRFKELADAKKNVFDEDLEAIVYEELYRVEDKYKLIY-LNVVSGNVAIPTATMQM 414 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDA 466 E +I ++ G G DA +A+ KIT + L+ Y V GG TDA Sbjct 415 EVDREIVQDAGFGVGPVDATFDAIRKITG----TNYDLLRYVVNAISGG-TDA 462 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Cupriavidus necator H16] Sequence ID: Q0KCT8.1 Length: 513 Range 1: 4 to 501 Score:186 bits(473), Expect:1e-51, Method:Compositional matrix adjust., Identities:151/518(29%), Positives:249/518(48%), Gaps:34/518(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IA+ L++L VD +E A S G+ E ++ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTREEKIRIAR-QLERLKVDVIEAGFAASSNGDFEAIRSIA 62 Query 67 EWAATEQLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 Q+ + I N + + +K + + ++ S H+EK+L TP Sbjct 63 ------QVVKDSTICSLARANDKDIARAAEALKPANSFRIHTFIATSALHMEKKLRMTPD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 E + + +A + I ED G R+ D++ ++E + E I LPDT+G Sbjct 117 EVYQQARLAVRFARQFTDDIEFSPED---GSRSDMDFLCRVLEGVIAEGATTINLPDTVG 173 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGL 237 PE + + S+ ++ P+ + H HND ++VANSL A++ AG + + +INGL Sbjct 174 YAVPEGYAELIRSVRERIPNSDKAIWSVHCHNDLGMAVANSLAAVKMAGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGNT LE +V + D + ++ I AS+LV +G + N+ +VG + Sbjct 234 GERAGNTSLEEVVMAVKTRRDYFDLDIGVDTTQIVPASKLVSQITGFVVQPNKAVVGANA 293 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEV 352 F +G+H DG K + E G LGKL+G+ + + +++LG+ L SE Sbjct 294 FAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGIELESET 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 + R EL DQ + ED+ I+++ + + S + S G RPHA++ Sbjct 354 EVNAAFTRFKELADQKAEIFDEDIVAIVSNEAQHDANEHFRFISLSQRSETGERPHARVV 413 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G+ EG+G DA ++A I +R+ S +++ Y V GG T+A E + Sbjct 414 FSMDGQEQSGEGEGNGPVDATLHA---IESRVS-SGAEMVLYSVNAITGG-TEAQGEVTV 468 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 +K+ + +G PD A+ A LN++ Sbjct 469 RLSKA-----GRIVNGVGTDPDIVAASAKAYLAALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus subsp. marinus str. CCMP1375] Sequence ID: Q7VBG1.1 Length: 536 Range 1: 1 to 517 Score:186 bits(472), Expect:2e-51, Method:Compositional matrix adjust., Identities:155/535(29%), Positives:249/535(46%), Gaps:42/535(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S+G+ + Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDIIEAGFPYASQGDFK 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I + E E I G +K + I + K ++ S HL+ + Sbjct 60 AVQRIADQVGGE---EGPIICGLARASKADIKACAEAIAPAPRKRIHTFIATSDIHLKHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ + V ++ YA + ED + R+ PD++ ++E I Sbjct 117 LRKSRADVLKIVPEMVGYARSLASDVEFSCEDAA---RSDPDFMYEVIESAIAAGAGTIN 173 Query 176 LPDTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G ++P E G++ + + HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGYITPAEFGDLIIGINKNVSNIDESILSVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIHDK-----------SNSKTNINEI---AITEASRLVEVF 278 +ING+GERAGN LE LV +H + S S T + I IT+ SRLV Sbjct 234 TINGIGERAGNAALEELVMALHVRRRYFNPFFGKDSESPTPLTAIRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L + + G + +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGANAFAHESGIHQDGVLKNPLTYEIVDAKTVGLAENRISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + +++LG L+ L R +L D+ + ++ DL I+++ + E + Sbjct 354 VRARLEELGYDLTREDLNDAFARFKDLADRKREISDRDLEAIVSEQVMQP-EARFKLHLV 412 Query 398 NIHSGIGIRPHAQIELEYQGKI-HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV 456 + G +RP A + + Q I + ++ G G DA AL +TN LI++ V Sbjct 413 QVSCGTALRPTATVTIADQDGIENTAVALGTGPVDAVCKALRSLTNEKN----DLIEFSV 468 Query 457 RIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + G DAL E I + + + F D VAA A LN+++ Sbjct 469 KSVTEG-IDALGEVTIRLRR-----DGKIFSGHSADTDVVVAAAQAYINALNRLV 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Cupriavidus metallidurans CH34] Sequence ID: Q1LPX2.1 Length: 513 Range 1: 4 to 471 Score:186 bits(471), Expect:2e-51, Method:Compositional matrix adjust., Identities:143/482(30%), Positives:230/482(47%), Gaps:29/482(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IA+ L++L VD +E A S G+ E ++ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTREEKIRIAR-QLERLKVDVIEAGFAASSNGDFEAIRSIA 62 Query 67 EWAATEQLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 Q+ + I N + + +K + + ++ S H+EK+L TP Sbjct 63 ------QVVKDSTICSLARANDKDIARAAEALKPANSFRIHTFIATSALHMEKKLRMTPD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + + + +A + I ED G R+ D++ ++E + E I LPDT+G Sbjct 117 QVYEQARLAVRFARQFTDDIEFSPED---GSRSDMDFLCRVLEGVIAEGATTINLPDTVG 173 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGL 237 PE + + S+ ++ P+ + H HND ++VANSL A++ G + + +INGL Sbjct 174 YAVPEGYAELIRSVRERIPNSDKAVWSVHCHNDLGMAVANSLAAVKLGGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGNT LE +V + D N I+ I AS+LV +G + N+ +VG + Sbjct 234 GERAGNTSLEEVVMAVKTRRDYFNMDVGIDTTQIVPASKLVSQITGFVVQPNKAVVGANA 293 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEV 352 F +G+H DG K + E G LGKL+G+ + + +++LG+ L SE Sbjct 294 FAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVQLESEA 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 + R EL DQ + ED+ I++D + S + S G RPHA++ Sbjct 354 EINAAFARFKELADQKAEIFDEDIMAIVSDEEQEHANEHYRFISLSQRSETGERPHARVV 413 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTDALVETR 471 G +EG+G DA ++A+ N S +L+ Y V I G + V R Sbjct 414 FNIDGSEQTGEAEGNGPVDATLHAIEGKVN----SGAELVLYSVNAITAGTQAQGEVTVR 469 Query 472 IT 473 ++ Sbjct 470 LS 471 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Polaromonas naphthalenivorans CJ2] Sequence ID: A1VN06.1 Length: 512 Range 1: 4 to 501 Score:185 bits(470), Expect:3e-51, Method:Compositional matrix adjust., Identities:148/513(29%), Positives:242/513(47%), Gaps:24/513(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E V+ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTRDEKLRIAR-QLERLKVDVIEAGFAASSNGDFECVKAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 E + + D ++ + +K + + L+L S H+EK+L TP + F Sbjct 63 EVVKDSTICS-LARANDRDISRAAEALKPANSGRLHLFLATSALHMEKKLRMTPDQVFEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A I ED G+R+ PD++ ++E + E I +PDT+G PE Sbjct 122 ARLSVRFARNLMADIEFSPED---GYRSDPDFLCRVIEAVINEGATTINVPDTVGYAIPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNFIRNLRERIPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + + + I+ I ASRLV +G + N+ +VG + F + Sbjct 239 NCSLEEVVMAVKTRKDYFGLDIGIDTQQILAASRLVSQTTGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ + SE + Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVAMESETDINNA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 + +L D+ + ED+ +++D S + S + HS G RP A + G Sbjct 359 FIKFKDLADRKSEIFDEDILALVSDESVTHSNEQYGFVSLSQHSETGERPQACVIFTVAG 418 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 K K S+G+G DA + A+ S +++ Y V G T++ E + S Sbjct 419 KEVKGESDGNGPVDASLKAIETHVK----SGAEMVLYSVN-AISGSTESQGEVTVRLQNS 473 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +G PD VA+ A LN++ Sbjct 474 -----GRVVNGVGSDPDIVVASAKAYLSALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitratidesulfovibrio vulgaris str. 'Miyazaki F'] Sequence ID: B8DM91.1 Length: 514 Range 1: 1 to 502 Score:185 bits(470), Expect:3e-51, Method:Compositional matrix adjust., Identities:149/525(28%), Positives:246/525(46%), Gaps:38/525(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 MT R+ I D TLRDGEQ+ G + + EK+ +A+ L+ L VD +E S+G+ E Sbjct 1 MTIESGRIRIFDTTLRDGEQSPGATMNLQEKIRLAR-QLETLGVDIMEAGFPASSQGDFE 59 Query 61 TVQKIMEWAATEQLTERIEILGFV-----DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ I + + +E+ G D ++ + +K + ++ S H++ + Sbjct 60 AVQAIA------RAVKGVEVAGLCRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQYK 113 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K P + + +A K + ED S R++PD++ + E + I Sbjct 114 LRKEPDQVVEMAVAAVRHAAKYTSNVEFSAEDAS---RSNPDFLVRVFEAVINAGATTIN 170 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G PEE + + +I+ P+ H F H HND + VAN+L A++AG + Sbjct 171 VPDTVGYAQPEEFGRLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEV 230 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITE----ASRLVEVFSGKRISANRP 288 +I+G+GERAGN LE +V +H + + ++ +TE RL+ + G+ I N+ Sbjct 231 TISGIGERAGNASLEEIVMALHTRRDF-YQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKA 289 Query 289 IVGEDVFTQTAGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGM 347 IVG + F +G+H DG K + PE G+ K +GK +G+ ++ + +LG Sbjct 290 IVGANAFAHESGIHQDGMLKNRETYEIMTPESIGKTKTDLVIGKHSGRNAVKNKLDELGY 349 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRP 407 L E L V E V +L D+ K + ED+ ++ + R + + S G+ P Sbjct 350 RLEEAQLVTVFEAVKKLADKKKQIYDEDIEALVLEEVYRLPDLYRLVNLSVQCSDTGMPP 409 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 A + ++ G++ + G G DA N + +I R P L Y V GG TDA Sbjct 410 TAAVVMDVMGEVKRAAGFGVGPIDAVFNVIGEIVGRA----PVLERYSVTAITGG-TDAQ 464 Query 468 --VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 V R+ N S + G PD +A+ A LN++ Sbjct 465 GEVTVRLRQNGSSAVGR-------GSDPDIILASARAYVNALNRL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitratiruptor sp. SB155-2] Sequence ID: A6Q4V5.1 Length: 514 Range 1: 5 to 459 Score:185 bits(470), Expect:3e-51, Method:Compositional matrix adjust., Identities:151/474(32%), Positives:225/474(47%), Gaps:33/474(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 ++I D TLRDGEQ+ G S +T EK+ IAK L+KL VD +E A S G+ E ++KI E Sbjct 5 VKIFDTTLRDGEQSPGASMNTEEKIQIAK-QLEKLGVDVIEAGFAAASPGDFEAIRKISE 63 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 + L D + I + K ++ S H++ +L P E Sbjct 64 VVQKSTVCSLARALE-KDIKAAGEAIAPAKHKRIHTFIATSPIHMKYKLRMEPDEVIKRA 122 Query 128 SFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 ++YA ++ED + R+ ++K ++ + + I +PDT+G Sbjct 123 VEAVQYA-------KTFVEDVEFSCEDAGRSEMSFLKEIILAVIEAGAGTINIPDTVGYR 175 Query 184 SPEETFQGVDSLIQKYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 P E + + L + D H HND L+VANSL ++ G + + +INGLGERAG Sbjct 176 FPHEMGEMIKELHETIQDRAVISVHCHNDLGLAVANSLYSVLNGARQVECTINGLGERAG 235 Query 243 NTPLEALVTTIHDK----SNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 N LE +V I + + TNIN I SRLV +G N+ IVG++ F Sbjct 236 NAALEEIVMAIKTRKDIFGDIDTNINTKEIYPTSRLVAAITGIEPQPNKAIVGKNAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K + E G K + LGK +G+ + + +++LG LSE + K Sbjct 296 SGIHQDGVLKHQETYEIMRAEDIGLDKNAIVLGKHSGRHAFKKKIEELGFSLSEEEINKA 355 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGE----KVLTIKSCNIHSGIGIRPHAQIEL 413 ER L D+ K VT +D+ +I + E K L I C+ G+ P A + + Sbjct 356 FERFKMLADKKKEVTDDDIRMLITNEIASAPEVYKLKKLQINDCS--EGV---PSAAVTV 410 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 EY+GK + GDG DA + +IT G KL DY+V GK DAL Sbjct 411 EYEGKEITDAGIGDGTIDAIFKTIDRITGVQG----KLNDYQVIAVSKGK-DAL 459 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Sediminispirochaeta smaragdinae DSM 11293] Sequence ID: E1R5X1.1 Length: 505 Range 1: 4 to 437 Score:184 bits(468), Expect:4e-51, Method:Compositional matrix adjust., Identities:130/445(29%), Positives:223/445(50%), Gaps:25/445(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R++I D TLRDGEQ+ G S S +K+ +A L++L VDR+E S + E VQ++ Sbjct 4 RIKIFDTTLRDGEQSPGASMSLEQKIKMAS-ALERLGVDRIEAGFPVSSPVQFEAVQRV- 61 Query 67 EWAATEQLTERIEILGFV-----DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 +AT ++ E++G D + D ++D+ +L++ S H E +L K+ + Sbjct 62 --SAT---VKKAEVVGLARCVQRDIDAAYDALRDAAHPMLHIFIATSPLHREYKLKKSKE 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 E V + Y K ++ ED S R PDY+ +V+ + I +PDT+G Sbjct 117 EILDTVRECLNYGGKGFSRMEFSPEDAS---RTEPDYLVEVVKTAIECGATSINIPDTVG 173 Query 182 VLSPEETFQGVDSLIQKYP-----DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 P+E Q + L+++ P + H HND L++ANSL A+R+G + ++NG Sbjct 174 YAVPKEFGQLISFLVEQVPQFSDGSVDLSVHCHNDLGLALANSLAAVRSGASQVEVTLNG 233 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 +GERAGN P+E L+ ++ D + +T I+ + +L++ +G I N+PI G++ Sbjct 234 IGERAGNCPMEELIMSLDVRKDMFDVETGIHTEYLYPTGKLLQSITGLLIPRNKPIFGDN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGMVLSEV 352 VF +G+H G + PER GR + +G+ +GK ++ + + Q + L+ Sbjct 294 VFVHESGIHQHGVLNKRETYEIMKPERIGRSSETIIMGRHSGKHALEDKLSQYNIKLTRQ 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 + V R + D+ K V EDL I+ V G K ++ + +G + P A ++ Sbjct 354 QFEDVFARFTAIADKKKEVYDEDLFSIVGTVLGGV-VKGFSLLYFHTFTGNSLIPGATVK 412 Query 413 LEYQGKIHKEISEGDGGYDAFMNAL 437 + + + GDG DA NA+ Sbjct 413 VRSEAGEKVASATGDGPVDAVFNAI 437 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Polaromonas sp. JS666] Sequence ID: Q12B47.1 Length: 513 Range 1: 4 to 502 Score:184 bits(468), Expect:6e-51, Method:Compositional matrix adjust., Identities:150/515(29%), Positives:241/515(46%), Gaps:27/515(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E VQ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKDEKLRIAR-QLERLKVDVIEAGFAASSNGDFEAVQAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D ++ + +K + ++ S H+EK+L TP++ Sbjct 63 NTIRDSTICS-LSRANDRDISRAAEALKGANNARIHTFIATSALHMEKKLRMTPEQVLEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A + ED G+R+ DY+ ++E + E I +PDT+G PE Sbjct 122 ARLSVRFARNLVADVEFSPED---GYRSDVDYLCRVLEAVIDEGATTINVPDTVGYAVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL + G + + +INGLGERAG Sbjct 179 LYGHFIKTLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVMIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + D N + NI+ + I ASR+V +G + N+ +VG + F + Sbjct 239 NCSLEEIVMAVKTRKDYFNLEMNIDPLHIVAASRMVSQTTGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G S LGKL+G+ + + ++ LG+ L SE + Sbjct 299 GIHQDGMLKARETYEIMRAEDVGWSASKMVLGKLSGRNAFKQRLQDLGVALESEADINTA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVS-GRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 R EL D+ + ED+ +++D S ++ S HS G RPHA + Sbjct 359 FARFKELADRKSEIFDEDILALVSDESITHHDQEQYGFVSLAQHSETGERPHAVVVFTVA 418 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGG-KTDALVETRITWN 475 GK + S+G+G DA + A+ S +++ Y V G ++ V R+ N Sbjct 419 GKEIRGESDGNGPVDASLKAIETHVK----SGAEMVLYSVNAISGSTESQGEVTVRLQNN 474 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +G PD VA+ A LN++ Sbjct 475 G-------RVVNGVGADPDIVVASAKAYLSALNKL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Picosynechococcus sp. PCC 7002] Sequence ID: B1XLQ9.1 Length: 533 Range 1: 1 to 521 Score:185 bits(469), Expect:7e-51, Method:Compositional matrix adjust., Identities:156/542(29%), Positives:249/542(45%), Gaps:48/542(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M + R+ I D TLRDGEQ+ G + + EKL IA+ L +L VD +E R S+G+ + Sbjct 1 MNNQDDRIIIFDTTLRDGEQSPGATLNGDEKLAIAR-ALARLGVDVIEAGFPRASRGDFD 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I TE I G K + +K + + ++ S HLE + Sbjct 60 AVQRIAAEVGTENGPT---ICGLARATKGDIEAAGNALKPAFSNRIHTFIATSDIHLEYK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ K+ ++ YA + ED R+ P+++ ++E + + Sbjct 117 LRKSRKDVLAIAPEMVAYAKTFTNDVEFSPEDAG---RSDPEFLYQILEAVIDAGATTVN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + + + P+I HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGYTTPAEFGALIKGIKENVPNIDRAIISVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV +H D T+IN I + SRLV Sbjct 234 TINGIGERAGNAALEELVMALHVRRQYYNPFLGRPADSEAPLTSINTKEIYKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + AN+ IVG + F +G+H DG K L + + G LGK +G+ + Sbjct 294 TGLSVQANKAIVGLNAFAHESGIHQDGVLKNKLTYEIMDAQSIGLTDNQIILGKHSGRNA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + +LG LS+ L K R +L D+ K +T DL I+ D + + E + ++ Sbjct 354 FRTRLAELGFDLSDNDLNKAFLRFKDLADKKKEITDWDLEAIVKDETQQPPE-LFRLELV 412 Query 398 NIHSGIGIRPHAQIELEYQGKIHKEISE---GDGGYDAFMNALTKITNRLGISIP-KLID 453 + G +P A I + G KE+++ G G DA A+ ++ + +P +LI+ Sbjct 413 QVSCGDHAQPTATITIRTPGG--KELTDAAIGTGPVDAIYKAINRV-----VQVPNELIE 465 Query 454 YEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQP 513 Y V+ G DA+ E I E + + + D VA+ A LN++ Sbjct 466 YSVQSVTAG-IDAIGEVTIRLR-----HEGRIYSGHAANTDIVVASARAYISALNRLYAA 519 Query 514 WQ 515 Q Sbjct 520 LQ 521 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Acidovorax sp. JS42] Sequence ID: A1W6T7.1 Length: 512 Range 1: 4 to 501 Score:184 bits(467), Expect:9e-51, Method:Compositional matrix adjust., Identities:148/513(29%), Positives:242/513(47%), Gaps:24/513(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E+VQ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTRDEKLRIAR-QLERLRVDVIEAGFAASSNGDFESVQAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + + D + + +K++ ++ S H+EK+L TP++ Sbjct 63 R-AVKDSTVCSLARANDRDIARAAEALKEANRARIHTFIATSALHMEKKLRMTPEQVLEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A I ED G+R+ PD++ ++E + E I +PDT+G PE Sbjct 122 ARQAVRFARNLVEDIEFSPED---GYRSDPDFLCRVIETVIAEGATTINVPDTVGYAIPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + + + I+ I ASR+V +G + N+ +VG + F + Sbjct 239 NCSLEEVVMAVKTRRDYFGLDVGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE + Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVQLESEGEINVA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 + EL D+ + ED+ +++D S + ++ S HS G RP A I G Sbjct 359 FAKFKELADRKSEIFDEDILALVSDESVTSEKEQFGFVSLAQHSETGERPEATIVFTVDG 418 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 K + SEG+G DA M A+ S +++ Y V G T++ E + + Sbjct 419 KEVRSSSEGNGPVDASMKAIEAHVR----SGAEMVLYSVN-AISGSTESQGEVTVRLQSA 473 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +G PD VA+ A LN++ Sbjct 474 -----GRVVNGVGADPDIVVASAKAYLSALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pyrococcus furiosus DSM 3638] Sequence ID: Q8U2A2.1 Length: 499 Range 1: 4 to 497 Score:183 bits(465), Expect:1e-50, Method:Compositional matrix adjust., Identities:159/516(31%), Positives:253/516(49%), Gaps:34/516(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +++I D TLRDGEQT GVS + EK+ IAK L +LNVD +E S GE E V++I Sbjct 4 KIKIFDTTLRDGEQTPGVSLTVEEKIEIAK-QLARLNVDVIEAGFPISSPGEFEAVKRI- 61 Query 67 EWAATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 A E I L D + + +KD+ +K ++ SL H++ +L KTP+E Sbjct 62 ---AREVRGPTIAALARAVKKDIDAAGEALKDAESKRIHTFIATSLIHMKYKLRKTPEEV 118 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 +EYA K I ED + R+ +++ + E + I +PDT+G Sbjct 119 KKMAVEAVEYATKYTDDIEFSAEDAT---RSDWNFLVEVYEAVIDAGATTINVPDTVGYT 175 Query 184 SPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +PEE ++ + L I + H HND L+VANSL A+RAG + ++NG+GER Sbjct 176 TPEEFYELIRYLKRNITNLNGVTISVHCHNDLGLAVANSLSAVRAGADQVEVTVNGIGER 235 Query 241 AGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGN LE +V + D N +T IN I S+LV +G + N+ +VG + F Sbjct 236 AGNAALEEVVVALDVRKDFYNVETGINLGEIARTSKLVARLTGIEVPPNKAVVGANAFAH 295 Query 298 TAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I P + G S LGK +G+ + + ++++G LSE + + Sbjct 296 ESGIHQDGVLKERTTYEIIDPRKLGFSGSKIVLGKHSGRHAFRKKLEEMGYRLSEEEINR 355 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 + + E+ D+ K +T D+ I+ + G+ G+ +++ ++ SG +++ + Sbjct 356 LFAKFKEIADRKKGLTELDIEAIVQEELGK-GKGKYSVEVLHVISGKISTATVRVQGDGI 414 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE--TRITW 474 KI S +G DA A+ + LGI KL +Y V G+ DAL E R+ + Sbjct 415 DKIESAWS-SNGPIDALFAAINRA---LGIDC-KLKEYRVSSVTSGR-DALGEVLVRVEY 468 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 N + + G+ D A+ A LN+I Sbjct 469 N-------GEIYVGRGLSTDIIEASAQAYLSALNRI 497 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. NATL1A] Sequence ID: A2C3L7.1 Length: 539 Range 1: 1 to 517 Score:183 bits(465), Expect:2e-50, Method:Compositional matrix adjust., Identities:158/535(30%), Positives:248/535(46%), Gaps:42/535(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASPGDFA 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQKI E E E I G +K + I + K ++ S HLE + Sbjct 60 AVQKIAENVGGE---EGPIICGLSRASKPDIKACANAIAPAPKKRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ KE V ++ YA + ED + R+ D++ ++E I Sbjct 117 LRKSRKEVLDIVPDMVGYAKSFVDDVEFSCEDAA---RSDLDFLYEVIELAISSGANTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G ++P E + ++ + P+I+ HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGYITPSEFGDLILNINENVPNINEAVLSVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE L+ +H + T + IT++SRLV Sbjct 234 TINGIGERAGNAALEELIMALHVRRSYFNPFFGRPPESPTPLTAVRTEEITKSSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L I + G +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + ++ LG L+ L R +L D+ + +T DL I+++ + E + +K Sbjct 354 VRARLEDLGYDLNREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEALFQLKLV 412 Query 398 NIHSGIGIRPHAQIELEYQ-GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV 456 + G + P A + + + G+ +S G G DA + AL +T +LI++ V Sbjct 413 QVSCGTSLMPTATVTVVGEDGEEKTAVSLGTGPVDAVVRALDSLTEEPN----ELIEFSV 468 Query 457 RIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + G DAL E I + +L F D VAA A LN+++ Sbjct 469 KSVTEG-IDALGEVTIRIRRDGNL-----FSGHSADTDVVVAAAQAYINALNRLV 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [[Acidovorax] ebreus TPSY] Sequence ID: B9MA32.1 Length: 512 Range 1: 4 to 501 Score:183 bits(464), Expect:2e-50, Method:Compositional matrix adjust., Identities:147/513(29%), Positives:242/513(47%), Gaps:24/513(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E+VQ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTRDEKLRIAR-QLERLRVDVIEAGFAASSNGDFESVQAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + + D + + +K++ ++ S H+EK+L TP++ Sbjct 63 R-AVKDSTVCSLARANDRDIARAAEALKEANRARIHTFIATSALHMEKKLRMTPEQVLEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A I ED G+R+ PD++ ++E + E I +PDT+G PE Sbjct 122 ARQAVRFARNLVEDIEFSPED---GYRSDPDFLCRVIETVIAEGATTINVPDTVGYAIPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + + + I+ I ASR+V +G + N+ +VG + F + Sbjct 239 NCSLEEVVMAVKTRRDYFGLDVGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE + Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVQLESEGEINVA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 + EL D+ + ED+ +++D S + ++ S HS G RP A I G Sbjct 359 FAKFKELADRKSEIFDEDILALVSDESVTSEKEQFGFVSLAQHSETGERPEATIVFTVDG 418 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 K + +EG+G DA M A+ S +++ Y V G T++ E + + Sbjct 419 KEVRSSAEGNGPVDASMKAIEAHVR----SGAEMVLYSVN-AISGSTESQGEVTVRLQSA 473 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +G PD VA+ A LN++ Sbjct 474 -----GRVVNGVGADPDIVVASAKAYLSALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. NATL2A] Sequence ID: Q46K01.1 Length: 539 Range 1: 1 to 517 Score:183 bits(465), Expect:3e-50, Method:Compositional matrix adjust., Identities:158/535(30%), Positives:248/535(46%), Gaps:42/535(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASPGDFA 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQKI E E E I G +K + I + K ++ S HLE + Sbjct 60 AVQKIAENVGGE---EGPIICGLSRASKPDIKACANAIAPAPKKRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ KE V ++ YA + ED + R+ D++ ++E I Sbjct 117 LRKSRKEVLDIVPDMVGYAKSFVDDVEFSCEDAA---RSDLDFLYEVIELAISSGANTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G ++P E + ++ + P+I+ HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGYITPSEFGDLILNINKNVPNINEAVLSVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE L+ +H + T + IT++SRLV Sbjct 234 TINGIGERAGNAALEELIMALHVRRSYFNPFFGRPPESPTPLTAVRTEEITKSSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L I + G +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + ++ LG L+ L R +L D+ + +T DL I+++ + E + +K Sbjct 354 VRARLEDLGYDLNREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEALFQLKLV 412 Query 398 NIHSGIGIRPHAQIELEYQ-GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV 456 + G + P A + + + G+ +S G G DA + AL +T +LI++ V Sbjct 413 QVSCGTSLMPTATVTVVGEDGEEKTAVSLGTGPVDAVVRALDSLTEEPN----ELIEFSV 468 Query 457 RIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + G DAL E I + +L F D VAA A LN+++ Sbjct 469 KSVTEG-IDALGEVTIRIRRDGNL-----FSGHSADTDVVVAAAQAYINALNRLV 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Paracidovorax citrulli AAC00-1] Sequence ID: A1TRT4.1 Length: 512 Range 1: 4 to 501 Score:182 bits(463), Expect:3e-50, Method:Compositional matrix adjust., Identities:151/514(29%), Positives:242/514(47%), Gaps:26/514(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E VQ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTRDEKLRIAR-QLERLRVDVIEAGFAASSNGDFEAVQAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A + + D + + +KD+ ++ S H+EK+L TP++ Sbjct 63 Q-AIKDSTVCSLSRANDRDIARAAEALKDAQRARIHTFIATSPLHMEKKLRMTPEQVLEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A I ED G+R+ PD++ ++E + E I +PDT+G PE Sbjct 122 AKQSVRFARNLVADIEFSPED---GYRSEPDFLCRVLEAVIAEGATTINVPDTVGYAIPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNFIRNLRERIPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + + + + I+ I ASR+V +G + N+ +VG + F + Sbjct 239 NCSLEEIVMAVKTRRDYFGLELGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + ++ LG+ L SE + Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQDLGVQLESEADVNAA 358 Query 358 LERVIELGDQNKLVTPED-LPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 R EL D+ + ED L + D + GE+ + S + S G RPHA + Sbjct 359 FLRFKELADRKSEIFDEDILALVSGDATAGAGERYGFV-SLSQRSETGERPHAAVVFTVD 417 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNK 476 GK SEG+G DA + A+ + S +++ Y V G T++ E + Sbjct 418 GKEVHGASEGNGPVDASLKAIESHVH----SGAEMVLYSVN-AISGSTESQGEVTVRLQD 472 Query 477 SLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 S + +G PD VA+ A LN++ Sbjct 473 S-----GRVVNGVGADPDIVVASAKAYLSALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Polynucleobacter necessarius STIR1] Sequence ID: B1XUJ3.1 Length: 515 Range 1: 7 to 506 Score:182 bits(462), Expect:4e-50, Method:Compositional matrix adjust., Identities:147/517(28%), Positives:243/517(47%), Gaps:28/517(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ+ G S + EK+ IA+ L++L VD +E A S+G+ + + + A Sbjct 7 IFDTTLRDGEQSPGASMTKDEKVRIAR-QLERLKVDVIEAGFAASSEGDFQAISAVAA-A 64 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 + + + D + D ++ + AK ++ S H+ +L +P+E Sbjct 65 VKDSIVCSLARANDKDITRAADALQATNAKRIHAFLATSPLHMAVKLRMSPEEVLEQAKR 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 I +A I ED G+R+ D++ +VE + E I +PDT+G +PE Sbjct 125 SIRFACNLASDIEFSAED---GYRSEMDFLCRVVEAVINEGASTINIPDTVGYATPELYG 181 Query 190 QGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAGNTP 245 + + +L + P+ + H HND ++VANSL ++ G + + +INGLGERAGNT Sbjct 182 EFIKTLRTRVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTA 241 Query 246 LEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 LE +V ++ D + I+ I AS+LV +G + N+ +VG + F T+G+H Sbjct 242 LEEIVMSLRTRKDYFDMVCGIDATQIVPASKLVSQITGFIVQPNKAVVGANAFAHTSGIH 301 Query 303 ADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKVLER 360 DG K + E G LGKL+G+ + + +++LG+ + +E L R Sbjct 302 QDGILKNRDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGITVEAEADLNVAFTR 361 Query 361 VIELGDQNKLVTPEDLPFIIAD-VSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 L DQ + ED+ I++D + GE I S + HS G RP +++ + Sbjct 362 FKALADQKSEIFDEDIIAIMSDSAAAEEGEHYKFI-SLSQHSETGERPKSRVTFRMGDRE 420 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTDALVETRITWNKSL 478 +EG+G DA +NA+ I S + + Y V I G ++ V R+ + Sbjct 421 ISSEAEGNGPVDASLNAIEGIAK----SGAEQLLYSVNAITSGTQSQGEVTVRLAKGGRI 476 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 +G PD A+ A LN++ P Q Sbjct 477 -------VNGVGTDPDIIAASAKAYLSALNKLHDPSQ 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Synechococcus sp. WH 7803] Sequence ID: A5GM47.1 Length: 540 Range 1: 7 to 487 Score:183 bits(464), Expect:4e-50, Method:Compositional matrix adjust., Identities:145/494(29%), Positives:230/494(46%), Gaps:37/494(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ VQ+I Sbjct 7 RVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASPGDFNAVQRIA 65 Query 67 EWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 + EQ I G ++ D + + + ++ S HLE +L K+ + Sbjct 66 QQVGGEQGPI---ICGLARASRGDIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRQ 122 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 E V ++ YA + ED R+ P+++ +++E I +PDT+G Sbjct 123 EVLAIVPEMVAYARSLVDDVEFSCEDAG---RSDPEFLYAVIEAAINAGASTINIPDTVG 179 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 +P E + + Q P+I HGHND L+VAN L+A++ G + L +ING+G Sbjct 180 YTTPAEFGALIAGIDQHVPNISEAVLSVHGHNDLGLAVANFLEAVKNGARQLECTINGIG 239 Query 239 ERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSGKRIS 284 ERAGN LE LV +H D T + IT+ SRLV +G + Sbjct 240 ERAGNAALEELVMALHVRRRYFNPFFGRAEDSPTPLTGVRTEEITKTSRLVSNLTGMVVQ 299 Query 285 ANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVK 343 N+ IVG + F +G+H DG K L + G +LGKL+G++++ ++ Sbjct 300 PNKAIVGANAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLE 359 Query 344 QLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGI 403 +LG LS L R EL D+ + +T DL I+++ + + +K + G Sbjct 360 ELGYDLSREDLDDAFARFKELADRKRDITDRDLEAIVSEQVQQPDAR-YQLKLVQVSCGS 418 Query 404 GIRPHAQIE-LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGG 462 ++P A + L+ +G+ E + G G DA AL N L +L+++ V+ G Sbjct 419 SLQPTATVTLLDEEGQEQSEAAIGTGPVDAVCRAL----NALAGEPNELVEFSVKSVTEG 474 Query 463 KTDALVETRITWNK 476 DA+ E I + Sbjct 475 -IDAMGEVTIRLRR 487 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Crocosphaera subtropica ATCC 51142] Sequence ID: B1WQQ4.1 Length: 537 Range 1: 10 to 521 Score:182 bits(463), Expect:5e-50, Method:Compositional matrix adjust., Identities:163/537(30%), Positives:239/537(44%), Gaps:56/537(10%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ E VQKI + Sbjct 10 IFDTTLRDGEQSPGASLTVEEKLTIAR-ALARLGVDIIEAGFPYASPGDFEAVQKIAKTV 68 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 E I G K + IK +G + L K +H HL+ +L KT + Sbjct 69 GNESGPR---ICGLARATK--NDIKAAG-EALKPAFKSRIHTFIATSDIHLKHKLKKTRQ 122 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 E V ++ YA + ED R+ P+++ ++E + +PDT+G Sbjct 123 EVLAIVPEMVAYAKTFTDDVEFSPEDAG---RSDPEFMYQVLETAIAAGATTVNIPDTVG 179 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 +P E + + P+I HGH+D L+VAN L+A++ G + L +ING+G Sbjct 180 YTTPSEFGALIKGIKDNVPNIDQAIISVHGHDDLGLAVANFLEALKNGARQLECTINGIG 239 Query 239 ERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSGKRIS 284 ERAGN LE LV +H D TNIN I + SRLV +G + Sbjct 240 ERAGNAALEELVMALHVRRQYFNPFLGRPVDSMEPLTNINTKEIYKTSRLVSNLTGMIVQ 299 Query 285 ANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVK 343 N+ IVG + F +G+H DG K L + E G LGKL+G+ + + Sbjct 300 PNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRNAFRTRLD 359 Query 344 QLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV---LTIKSCNIH 400 +LG LSE L R E+ D+ K +T DL I+ D + E L SC H Sbjct 360 ELGFELSERDLNNAFLRFKEVADKKKEITDWDLEAIVNDEIQQAPELFRLELVQVSCGDH 419 Query 401 SGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRI 458 S P A + L +GK + + G G DA A+ ++ N +P +LI++ V+ Sbjct 420 SA----PTATVTLRTPEGKELTDAAIGTGPVDAVYKAINRVVN-----VPNELIEFSVKS 470 Query 459 PPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 G DA+ E I E + + + D A+ A LN++ Q Sbjct 471 VTAG-IDAMGEVTIRLR-----HEGRIYSGYAANTDIITASARAYISALNRLYGAIQ 521 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thermosynechococcus vestitus BP-1] Sequence ID: Q8DJ32.1 Length: 535 Range 1: 12 to 524 Score:182 bits(463), Expect:5e-50, Method:Compositional matrix adjust., Identities:157/534(29%), Positives:243/534(45%), Gaps:49/534(9%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ E VQ+I Sbjct 12 RVLIFDTTLRDGEQSPGASLNVDEKLTIAR-QLARLGVDIIEAGFPFASPGDFEAVQRIA 70 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 E TE T + I G + ++ AK L +H HLE +L K Sbjct 71 ETVGTE--TGPV-ICGLARATR---QDIEAAAKALKPAYYPRIHTFIATSDIHLEYKLRK 124 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T E ++ YA + ED R+ P+++ ++E + + +PD Sbjct 125 TRAEVLEIAQEMVAYAKSFVDDVEFSPEDAG---RSDPEFLYEVLERVIDAGATTVNIPD 181 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +P E + + + P+I HGHND L+VAN L+A++ G + L +IN Sbjct 182 TVGYTTPAEFGALIKGIKENVPNIDRAVISVHGHNDLGLAVANFLEAVKNGARQLECTIN 241 Query 236 GLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSGK 281 G+GERAGN LE LV ++ + TNIN I + SRLV +G Sbjct 242 GIGERAGNAALEELVMALYVRRQYFNPFLGRPPESEAPLTNINTREIYKTSRLVSNLTGM 301 Query 282 RISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISE 340 I N+ IVG + F +G+H DG K + + G LGKL+G+ + + Sbjct 302 LIQPNKAIVGANAFAHQSGIHQDGVLKHKQTYEIMDAQLIGLADNQIVLGKLSGRNAFAT 361 Query 341 NVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIH 400 +++LG LSE L K R +L D+ K +T DL I D + + ++ + Sbjct 362 RLRELGFELSETELNKAFLRFKDLADKKKEITDWDLEAIAKDETQGIDLQGYQLEFVQVS 421 Query 401 SGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRI 458 G RP A + + G+ + + G G DA A+ ++ + IP +LI+Y V+ Sbjct 422 CGDHARPTATVTVRTPSGEELTDAAIGTGPVDAVYRAINRV-----VQIPNRLIEYSVQS 476 Query 459 PPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQ 512 G DA+ E I +D+ + + D VA+ A LN++ + Sbjct 477 VTAG-IDAIGEVTIRLQ-----HQDRIYSGHAANTDIIVASAQAYMNALNRLYR 524 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bradyrhizobium diazoefficiens USDA 110] Sequence ID: Q89GB0.1 Length: 520 Range 1: 11 to 510 Score:182 bits(461), Expect:6e-50, Method:Compositional matrix adjust., Identities:152/529(29%), Positives:251/529(47%), Gaps:49/529(9%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKL +A+ LL + VD +E S+G+ + V +I Sbjct 11 RVIIFDTTLRDGEQCPGATMTFEEKLEVAE-LLDDMGVDVIEAGFPITSEGDFQAVSEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 + + ++ + D D A+ + +G +H H+ +L K Sbjct 70 RRS-------KNAVIAGLSRAHPADI--DRCAEAVKFAKRGRVHTVIATSPLHMRVKLNK 120 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERI 174 TP++ VIE ++ + ++D WS +G R+ DY+ +VE + K + Sbjct 121 TPEQ-------VIETSVAMVARARNQIDDVEWSAEDGTRSEMDYLCRIVEAVIKAGATTV 173 Query 175 FLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLH 231 +PDT+G PEE + +LI++ P+ F H HND ++VANSL + G + + Sbjct 174 NIPDTVGYTVPEEYTHFMKTLIERVPNSDKAVFSVHCHNDLGMAVANSLAGVVGGARQVE 233 Query 232 ASINGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRP 288 +ING+GERAGN LE +V I +DK I+ +T AS++V + + N+ Sbjct 234 CTINGIGERAGNAALEEIVMAINVRNDKFPYWNKIDTTQLTRASKVVSAATSFPVQYNKA 293 Query 289 IVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGM 347 IVG + F +G+H DG K + PE G K+ S LGK +G+ + ++++G Sbjct 294 IVGRNAFAHESGIHQDGVLKDASTYEIMRPEMVGLKQSSLVLGKHSGRHAFVHKLEEMGY 353 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRP 407 L L+ R+ L D+ K + ED+ ++ + + +++ + S + +G Sbjct 354 KLGPNQLEDAFTRMKALADRKKDIYDEDIEALVDEEMAASHDRI-KLTSLTVIAGTHGPQ 412 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 A ++L+ G+I E +EG+G DA N + RL KL Y+V G TDA Sbjct 413 RATMKLDVDGQIKIEEAEGNGPVDAVFNCI----KRLVPHEAKLELYQVHAVTEG-TDAQ 467 Query 468 VETRITWNKSLDLEED-QTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 E S+ L D ++ PD VA+ A LN+I+ Q Sbjct 468 AEV------SVRLSHDGRSMTARAADPDTLVASAKAYLGALNKIVMKRQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Oceanobacillus iheyensis HTE831] Sequence ID: Q8EN67.1 Length: 515 Range 1: 2 to 467 Score:182 bits(461), Expect:7e-50, Method:Compositional matrix adjust., Identities:146/481(30%), Positives:242/481(50%), Gaps:29/481(6%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 +R++I D TLRDGEQ+ GV+ + +EKL IAK L+K VDR+E SKG+ E+V++I Sbjct 2 SRIKIFDTTLRDGEQSPGVNLNKAEKLEIAK-QLEKYGVDRMEAGFPASSKGDFESVKQI 60 Query 66 MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAK--VLNLLTKGSLHHLEKQLGKTPKEF 123 E T + + I + V + + + GA+ +++ S H+ +L K+P++ Sbjct 61 AE---TIKSSSVIALARAVKSDIDIAYEALKGAEKPAIHIFLATSPIHMTYKLKKSPEQV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 ++ YA + +I ED + R+ +++ ++E + + I LPDT+G Sbjct 118 IETAVNMVTYAKERFDEIEWSAEDAT---RSDWNFLAQIIEKVIEAGATVINLPDTVGYT 174 Query 184 SPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +PEE F+ + + + H HND ++VANS+ A+ G + +ING+GER Sbjct 175 TPEEYGKLFRFIKETVPNINQVALSCHCHNDLGMAVANSIAAVENGATQVEGTINGIGER 234 Query 241 AGNTPLEALVTTIHDKSNSKTNINEIAITEASR---LVEVFSGKRISANRPIVGEDVFTQ 297 AGN LE + + +S+ + + E R LV +G + AN+ ++G + F+ Sbjct 235 AGNAALEEVAVALKIRSDYYPFETGLILKETKRTSDLVAKLTGMYVQANKAVIGRNAFSH 294 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I PE G + LGK +G+ + + +K+ G+ LSE L+ Sbjct 295 ESGIHQDGVLKNTETYEIITPEMVGVSSNTLFLGKHSGRHAFKDKLKEFGVELSEEELKT 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGI----GIRPHAQIE 412 E+ L DQ K VT +DL I+ D+ +T V+ K I G+ P A + Sbjct 355 AFEQFKLLTDQKKEVTDDDLYTILMDI--KTDSTVVD-KYKLIQFGVSYDTAATPKANVI 411 Query 413 LEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETR 471 LE G + + +G+G + AL K N L L+DY++ GGK DAL E+ Sbjct 412 LESPNGSLIEATQQGNGS----VEALYKTINYLIAENITLVDYQINSVGGGK-DALAESH 466 Query 472 I 472 + Sbjct 467 V 467 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Microcystis aeruginosa NIES-843] Sequence ID: B0JGK2.1 Length: 533 Range 1: 1 to 517 Score:182 bits(461), Expect:8e-50, Method:Compositional matrix adjust., Identities:154/533(29%), Positives:238/533(44%), Gaps:39/533(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M R+ I D TLRDGEQ+ G + + EKL IA+ L +L VD +E S G+ + Sbjct 1 MNTSPDRVIIFDTTLRDGEQSPGAALNVDEKLTIAR-ALARLGVDVIEAGFPHASPGDFD 59 Query 61 TVQKIMEWAATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLG 117 VQKI +E + I L D D ++ + ++ S HL+ +L Sbjct 60 AVQKIAASVGSEADSPIICGLARTTQKDIKSAADALRPAAKPRIHTFLATSDIHLQYKLK 119 Query 118 KTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 KT +E V ++ YA + ED R+ PD++ ++E + +P Sbjct 120 KTRQEVLEIVPEMVAYAKSFVDDVEFSPEDAG---RSDPDFLYQVLERAIAAGATTVNIP 176 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G +P E + + + P+I HGH+D L+VAN L+A++ G + L +I Sbjct 177 DTVGYTTPSEFGALIRGIKENVPNIDQAIISVHGHDDLGLAVANFLEAVKNGARQLECTI 236 Query 235 NGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSG 280 NG+GERAGN LE LV +H + + T IN I SRLV +G Sbjct 237 NGIGERAGNASLEELVMALHVRRSYFNPFLGRPAESTEPLTKINTKEIYRTSRLVSNLTG 296 Query 281 KRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASIS 339 + N+ IVG + F +G+H DG K L + E G + LGKL+G+ + Sbjct 297 MIVQPNKAIVGANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTHNQIVLGKLSGRNAFR 356 Query 340 ENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNI 399 +++LG LSE L + E+ D+ K +T DL I+ D + ++ + Sbjct 357 SRLQELGFELSETELNNAFIQFKEMADRKKEITDRDLEAIVNDEIDTVPDH-FRLELVQV 415 Query 400 HSGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVR 457 G RP A + + G + + G G DA A+ ++ + IP +LI + VR Sbjct 416 SCGNSARPTATVTIRTPDGSELSDAAIGTGPVDALCKAIDRV-----VKIPNELISFSVR 470 Query 458 IPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 G DAL E I E +T+ D VA+ A LN++ Sbjct 471 EVTEG-IDALGEVTIRLRY-----EGRTYSAHAADTDIIVASARAYVSALNRL 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methylococcus capsulatus str. Bath] Sequence ID: Q605K7.1 Length: 514 Range 1: 4 to 505 Score:181 bits(460), Expect:8e-50, Method:Compositional matrix adjust., Identities:147/521(28%), Positives:240/521(46%), Gaps:31/521(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 RL I D TLRDGEQ+ G S + EK+ IA+ L++L VD +E S G+ E VQ + Sbjct 4 RLIIFDTTLRDGEQSPGASMTRDEKVRIAR-ALERLKVDVIEAGFPAASPGDFEAVQAVA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 ++ L D ++ + +KD+ ++ S H+ +L +P + Sbjct 63 RTIKDSRVCGLARALDR-DIDRAGEALKDAQRARIHTFIATSPIHMRHKLQMSPDQ---- 117 Query 127 VSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V+EYA+K+ + Y +D + R+ D++ ++E + + +PDT+G Sbjct 118 ---VVEYAVKAVKRARQYTDDVEFSPEDAGRSEEDFLCRILEAVIDAGATTLNIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 PE+ + LI++ P+ F H HND L+VANSL A+ G + + +INGLGE Sbjct 175 AFPEQFGHMIGRLIERIPNSDKAVFSVHCHNDLGLAVANSLAAVLHGARQVECTINGLGE 234 Query 240 RAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE +V + + + T+I I S+LV +G I N+ IVG + F Sbjct 235 RAGNAALEEIVMAVRTRKDIFPCHTDIETREIVACSKLVSSITGFPIQPNKAIVGANAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGM-VLSEVVL 354 +G+H DG K + E G LGK +G+ + +++LG+ SE L Sbjct 295 HESGIHQDGVLKSRETYEIMSAEDVGWSTNRMVLGKHSGRNAFRTRMQELGIEFASEEEL 354 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 V +R L D+ + EDL +I + ++ + + + + S G PHAQ+ ++ Sbjct 355 NSVFQRFKVLADKKHEIFDEDLQALITEAGAEAEDERVKLVALRVCSETGEIPHAQVTIK 414 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 + S G G DA + A+ + + + L Y V G TDA E + Sbjct 415 VDNEERTGTSSGGGAVDASLKAIESLLH----TDTALTLYSVNNITSG-TDAQGEVTVRL 469 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 K + Q G D +A+ A +N++L P Q Sbjct 470 EKGGRIVNGQ-----GADTDIVIASAKAYVNAVNKLLAPIQ 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methylibium petroleiphilum PM1] Sequence ID: A2SHL8.1 Length: 513 Range 1: 4 to 502 Score:181 bits(459), Expect:1e-49, Method:Compositional matrix adjust., Identities:148/514(29%), Positives:243/514(47%), Gaps:25/514(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E V+ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKDEKLRIAR-QLERLRVDVIEAGFAASSNGDFEAVRAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + E + D + + +K + ++ S H+EK+L T ++ Sbjct 63 D-VIKESTVCSLARANDRDIARAAEALKSAARSRIHTFIATSELHMEKKLRMTREQVLEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 I +A I ED G+R+ PD++ ++E + E I +PDT+G PE Sbjct 122 ARLSIRFARNLCEDIEFSPED---GYRSDPDFLCRVIEAVINEGATTINVPDTVGYGIPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNFIRTLRERVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + + + + I+ I ASRLV +G + N+ +VG + F + Sbjct 239 NCSLEEVVMAVRTRRDHFGLEVGIDTTQIVPASRLVSQTTGFIVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE + Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGIELESETDVNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY-Q 416 R +L D+ + ED+ ++ D S ++ + S S G RPHA++ + Sbjct 359 FARFKDLADRKSDIFDEDIIALVGDESVTHEQETYRLLSLEQQSATGERPHAKVAFAVGE 418 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNK 476 + H E SEG+G DA + A I ++L S +++ Y V G T++ E + Sbjct 419 TEFHAE-SEGNGPVDASLKA---IESKLK-SGAEMLLYSVNAITSGSTESQGEVTVRLQH 473 Query 477 SLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +G PD VA+ A LN++ Sbjct 474 G-----GRVVNGVGADPDIVVASAKAYLSALNKL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Solidesulfovibrio magneticus RS-1] Sequence ID: C4XPA8.1 Length: 513 Range 1: 4 to 501 Score:181 bits(458), Expect:1e-49, Method:Compositional matrix adjust., Identities:143/517(28%), Positives:249/517(48%), Gaps:30/517(5%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + R+ I D TLRDGEQ+ G + + EK+ +A+ L+ L VD +E S+G+ + V Sbjct 4 DNRVYIFDTTLRDGEQSPGATMTREEKVRMAR-QLETLGVDIIEAGFPAASEGDFQAVSA 62 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I T + L D ++ + IK + + ++ S H++ +L KTP + Sbjct 63 IAAAVKTPVVAALCRALA-SDIDRGFEAIKGAQRRRIHTFLATSELHMQHKLNKTPTQVL 121 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 + + +A G+++ ED S R+ P ++ + E + +PDT+G Sbjct 122 DMIEAAVSHAASKGVEVQFSAEDAS---RSEPAFLVAACERAINAGATILNIPDTVGYAQ 178 Query 185 PEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 P E + + L ++ + F H HND L+VAN+L A+ AG + +++G+GERA Sbjct 179 PAEFAELIRHLMTTVRGAGGVTFAVHCHNDLGLAVANTLAALHAGARQAEVTLSGIGERA 238 Query 242 GNTPLEALVTTIHDKSNSKTNINEIAITE----ASRLVEVFSGKRISANRPIVGEDVFTQ 297 GN LE +V ++ + N N+ +TE + R + G+ I PI+G + F Sbjct 239 GNASLEQVVMGLNTRPN-YYNLTTGIVTEELFPSCRRLSGIIGQPIPPYAPIMGRNAFAH 297 Query 298 TAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H G K + E GRK + LGK +G+ ++ VK+LG L++ L Sbjct 298 ESGIHQHGVLKDRRTYEIMTAESIGRKGAVVVLGKHSGRHALDAKVKELGYALNDEELLV 357 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSG-IGIRPHAQIELEY 415 V V +L D+ + + ED+ +I + R ++ ++ ++H G + + P A +E++ Sbjct 358 VFVAVKQLADRKQRILDEDIEALILEKVLRRPDR-YALQFLSVHCGNVELAPFAVVEMQV 416 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 +G+ + S G G DA NA+ + R P L +Y++ GG TDA E + Sbjct 417 EGQTVRHYSAGSGPVDAVFNAVCQAVGRK----PDLEEYQINAITGG-TDAQGEVTVRI- 470 Query 476 KSLDLEEDQTFKTM--GVHPDQTVAAVHATEKMLNQI 510 +D T T+ GVH D +A+ A LN++ Sbjct 471 ------KDGTATTVGRGVHDDVIMASTLAFINALNRL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methylacidiphilum infernorum V4] Sequence ID: B3DX88.1 Length: 506 Range 1: 1 to 473 Score:180 bits(456), Expect:3e-49, Method:Compositional matrix adjust., Identities:145/485(30%), Positives:233/485(48%), Gaps:22/485(4%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M RL + D TLRDGEQ G S ++ +KL +AK L +L VD +E +S+G+ E Sbjct 1 MEMTANRLIVFDTTLRDGEQCPGASMTSRQKLEVAK-QLARLGVDVIEAGFPVISQGDFE 59 Query 61 TVQKIMEWAATEQLTERIEIL-GFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKT 119 +V +I ++ L ++ A++ L +H K L K Sbjct 60 SVSEIAAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHRRFK-LAKD 118 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 +E + A + + ED S R P+++ +++ + + + +PDT Sbjct 119 EEEIVRIAVEGVRLAKRYVQDVEFSAEDAS---RTEPEFLAKIIQKVIEAGATTVNIPDT 175 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G PEE + L DI H HND L+V+NSL AI+AG + + +ING Sbjct 176 VGYAVPEEFASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEGTING 235 Query 237 LGERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 +GERAGN LE ++ +H + ++ +T I I SRLV SG + N+ +VGE Sbjct 236 IGERAGNAALEEIIMALHTRPDAFGKIETGIQLKEILRTSRLVSRMSGLAVQRNKAVVGE 295 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F AG+H DG K I P+ G ++S L K +G+A++ +K LG L + Sbjct 296 NAFAHAAGIHQDGILKKRETYEIIDPKIIGWEQSELPLTKHSGRAALENRLKILGFELEK 355 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQ 410 + + + ++GD+ K + +DL ++ R E L + + SG GI P A Sbjct 356 EEIDNIFSQFKQIGDKKKFIYDDDLVSLVEGQISRIKETYELEYVAVTVCSG-GI-PMAT 413 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 I+L + ++ + S GDG DA M A+ +IT + G L++YEV+ GK DA+ E Sbjct 414 IKLRHGEEVLVDASTGDGAVDAAMKAVDRITGQHG----HLVEYEVKSVTEGK-DAIGEV 468 Query 471 RITWN 475 + N Sbjct 469 TVKVN 473 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Trichormus variabilis ATCC 29413] Sequence ID: Q3MBA3.1 Length: 531 Range 1: 1 to 521 Score:180 bits(456), Expect:4e-49, Method:Compositional matrix adjust., Identities:157/537(29%), Positives:240/537(44%), Gaps:38/537(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 MT R+ I D TLRDGEQ G + + EKL IAK L +L VD +E A S G+ E Sbjct 1 MTTKPERIIIFDTTLRDGEQCPGATLNIDEKLAIAK-QLARLGVDIIEAGFAFASPGDFE 59 Query 61 TVQKIMEWAATEQ--LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGK 118 V KI + TE + + D + IK + ++ S HL+ +L K Sbjct 60 AVHKIAQTVGTENGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKK 119 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T E ++ YA + ED R+ P+++ ++E I +PD Sbjct 120 TRPEVIAIAEEMVAYAKSFTDDVEFSPEDAG---RSDPEFLYQVLERAIAAGATTINIPD 176 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +P E + + + P+I HGHND L+VAN L+A++ G + L +IN Sbjct 177 TVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTIN 236 Query 236 GLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSGK 281 G+GERAGN LE LV +H D TNI+ I + SRLV +G Sbjct 237 GIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEPLTNIDTKQIYKTSRLVSNLTGM 296 Query 282 RISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISE 340 + N+ IVG + F +G+H DG K L + + G LGK +G+ + Sbjct 297 LVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRT 356 Query 341 NVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIH 400 +K+LG LSE L K + E+ D+ K ++ DL I+ D + + ++ + Sbjct 357 RLKELGFELSETELNKAFVKFKEVADKKKEISDWDLEAIVND-EIQQAPDLFRVELVQVS 415 Query 401 SGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRI 458 G RP A + L G+ + + G G DA A+ ++ N +P +LI++ V+ Sbjct 416 CGSNARPTATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVN-----VPNQLIEFSVQS 470 Query 459 PPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 G DA+ E I E + F + D VA+ A LN++ Q Sbjct 471 VTAG-IDAIGEVTIRLRY-----ESRVFSGHAANTDIIVASAQAYVNALNRLYASLQ 521 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. MIT 9301] Sequence ID: A3PDH0.1 Length: 546 Range 1: 1 to 518 Score:180 bits(456), Expect:5e-49, Method:Compositional matrix adjust., Identities:156/537(29%), Positives:242/537(45%), Gaps:45/537(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+K R+ I D TLRDGEQ+ G S + EKL IA L +L VD +E S G+ + Sbjct 1 MSKNPGRILIFDTTLRDGEQSPGASLNLEEKLAIAH-QLARLGVDVIEAGFPFASPGDFK 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 V KI E I G +K + + + K ++ S HL+ + Sbjct 60 AVNKIASAVGKEHGPT---ICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ K+ V ++ YA I ED S R+ PD++ +++ I Sbjct 117 LKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDAS---RSDPDFLYEVIQLAISAGATTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + + + P+I HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGFTTPSEFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV +H D T I IT+ SRLV Sbjct 234 TINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L I + G +LGKL+G+++ Sbjct 294 TGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + ++++G LS L R +L D+ + +T DL I+++ + E + Sbjct 354 VRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEAKFQLSLV 412 Query 398 NIHSGIGIRPHAQIEL--EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDY 454 + G +P A I L +S G G DA AL K+ +P +LI++ Sbjct 413 QVSCGNASKPTATISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLA-----KVPNELIEF 467 Query 455 EVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 V+ G DAL E I + +++ + D VAA +A LN+++ Sbjct 468 SVKSVTEG-IDALGEVTIRIRR-----DNKIYSGHSADTDVVVAAANAYINALNRLV 518 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Microcystis aeruginosa] Sequence ID: P94907.1 Length: 533 Range 1: 1 to 517 Score:179 bits(455), Expect:5e-49, Method:Compositional matrix adjust., Identities:156/534(29%), Positives:240/534(44%), Gaps:41/534(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M R+ I D TLRDGEQ+ G + + EKL IA+ L +L VD +E S G+ E Sbjct 1 MNTSPDRVIIFDTTLRDGEQSPGAALNVDEKLTIAR-ALARLGVDVIEAGFPHASPGDFE 59 Query 61 TVQKIMEWAATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLG 117 VQKI +E + I L D D ++ + ++ S HL+ +L Sbjct 60 AVQKIAGSVGSEADSPIICGLARATQKDIKSAADALRPAAKPRIHTFLATSDIHLQYKLK 119 Query 118 KTPKEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFL 176 KT +E V ++ YA KS L + ED R+ P+++ ++E + + Sbjct 120 KTRQEVLEIVPEMVAYA-KSFLNDVEFSPEDAG---RSDPEFLYQVLERAIAAGATTVNI 175 Query 177 PDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHAS 233 PDT+G +P E + + + P+I HGH+D L+VAN L+A++ G + L + Sbjct 176 PDTVGYTTPSEFGALIRGIKENVPNIDQAIISVHGHDDLGLAVANFLEAVKNGARQLECT 235 Query 234 INGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFS 279 ING+GERAGN LE LV +H + + T IN I SRLV + Sbjct 236 INGIGERAGNASLEELVMALHVRRSYFNPFLGRPAESTEPLTKINTKEIYRTSRLVSNLT 295 Query 280 GKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASI 338 G + N+ IVG + F +G+H DG K L + E G LGKL+G+ + Sbjct 296 GMIVQPNKAIVGANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTNNQIVLGKLSGRNAF 355 Query 339 SENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCN 398 +++LG LSE L + E+ D+ K +T DL I+ D + ++ Sbjct 356 RSRLQELGFELSETELNNAFIQFKEMADRKKEITDRDLEAIVNDEIDTVPDH-FRLELVQ 414 Query 399 IHSGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEV 456 + G RP A + + G + + G G DA A+ ++ + IP +LI + V Sbjct 415 VSCGNNARPTATVTIRTPDGSELSDAAIGTGPVDALCKAIDRV-----VQIPNELISFSV 469 Query 457 RIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 R G DAL E I + +T+ D VA+ A LN++ Sbjct 470 REVTEG-IDALGEVTIRLRYA-----GRTYSARAADTDIIVASARAYVSALNRL 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aromatoleum aromaticum EbN1] Sequence ID: Q5NXN2.1 Length: 511 Range 1: 5 to 500 Score:179 bits(454), Expect:5e-49, Method:Compositional matrix adjust., Identities:151/519(29%), Positives:242/519(46%), Gaps:39/519(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 L + D TLRDGEQ+ G S + EKL IA+ L+++ VD +E S G+ E+V+ I E Sbjct 5 LIVFDTTLRDGEQSPGASMTRDEKLRIAR-QLERMRVDVIEAGFPAASNGDFESVRAIAE 63 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKT 119 A + T + G N+ I+ +G + + +G +H H+E +L + Sbjct 64 --AIREST----VCGLARANEAD--IRRAG-EAIAPAARGRIHTFIATSPIHMEMKLRMS 114 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 P + I +A + I ED R+ D++ + E + K + I +PDT Sbjct 115 PDQVVEQAVRAIGWAKEYTDDIEFSAEDAG---RSEIDFLCRIFEAVIKAGAKTINVPDT 171 Query 180 LGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G PE+ + +LI++ P + + H HND L+VANSL A+ AG + + ++NG Sbjct 172 VGYNVPEQYAHTIRTLIERVPGADKVVWSVHCHNDLGLAVANSLAAVMAGARQVECTLNG 231 Query 237 LGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGN LE LV + + + T I+ I AS+LV +G + N+ IVG + Sbjct 232 LGERAGNAALEELVMAVRTRQDVFPCDTRIDATQIVPASKLVSGVTGFPVQPNKAIVGAN 291 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SE 351 F +G+H DG K + E G LGK +G+ + ++++G+V+ SE Sbjct 292 AFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLVLGKHSGRNAFRSRLQEIGIVVASE 351 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L R EL D+ + ED+ +++D ++ + + HS G P A + Sbjct 352 EHLNHAFARFKELADKKHEIFDEDIQALMSDEVVTPDQEHYRLVASRFHSETGETPRADL 411 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETR 471 L G+ + +EG G DA A+ I S +L+ Y V G TDA E Sbjct 412 TLSVDGQETRTSAEGSGPVDAAFKAIEAIAG----SGTELLLYSVNAITTG-TDAQGEVT 466 Query 472 ITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + + ED+ G D VA+ A LN++ Sbjct 467 VRLAR-----EDKVVNGQGADTDIIVASAKAYLNALNKL 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Methylobacterium nodulans ORS 2060] Sequence ID: B8IHS8.1 Length: 520 Range 1: 11 to 506 Score:179 bits(454), Expect:6e-49, Method:Compositional matrix adjust., Identities:151/527(29%), Positives:244/527(46%), Gaps:53/527(10%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKL +A+ +L + VD +E S G+ + V +I Sbjct 11 RVLIFDTTLRDGEQCPGATMTFEEKLAVAE-MLDGMGVDIIEAGFPIASNGDFDAVAEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 T ++ + + D + + + L +G +H HL Q+ K Sbjct 70 RRTKTS-------VVAGLARAISADIAR--AGEAVRLAKRGRIHTFVSTSPIHLAHQMRK 120 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERI 174 + +E V+E K+ + +ED WS + R DY+ VE K I Sbjct 121 SEEE-------VLEIIQKTVAQARDLVEDVEWSAMDATRTPIDYLCRCVEMAIKMGATTI 173 Query 175 FLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLH 231 LPDT+G +P+E S+ ++ P+ F H HND L++ANSL I G + + Sbjct 174 NLPDTVGYATPDEYRAMFRSVRERVPNADRAIFSVHCHNDLGLAIANSLAGIEGGARQVE 233 Query 232 ASINGLGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRP 288 +ING+GERAGN LE +V + +++ T I+ I AS+LV + + N+ Sbjct 234 CTINGIGERAGNAALEEVVMALRTRADVLPYTTGIDTTQIMRASKLVAAATHFPVQYNKA 293 Query 289 IVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGM 347 +VG + F +G+H DG K + PE G +K S +GK +G+A+ +++LG Sbjct 294 VVGRNAFAHESGIHQDGMLKNQSTYEIMTPESVGVQKTSLVMGKHSGRAAFRSKLEELGY 353 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRP 407 LS+ Q ER L D+ K V ED+ ++ D + T + + S + +G Sbjct 354 RLSDNQFQDAFERFKALADRKKNVYDEDIEALV-DENLATAHDRIRLLSLTVIAGTRGPQ 412 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP---KLIDYEVRIPPGGKT 464 A + L+ G+ E ++G+G DA NA+ + +P KL Y+V G T Sbjct 413 RATMRLDIDGRQATEEADGNGPVDAVFNAIHAL-------VPHEAKLELYDVHAVTEG-T 464 Query 465 DALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 DA E + + +++ G PD VA+ A LN++L Sbjct 465 DAQAEVSVRLRQG-----ERSVTARGADPDTLVASAKAYLAALNKLL 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Carboxydothermus hydrogenoformans Z-2901] Sequence ID: Q3AEQ5.1 Length: 509 Range 1: 3 to 503 Score:179 bits(453), Expect:8e-49, Method:Compositional matrix adjust., Identities:156/516(30%), Positives:245/516(47%), Gaps:22/516(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ GVS + EKL IA+ LQKL VD +E S G+ E V I Sbjct 3 RVRIFDTTLRDGEQSPGVSLNAMEKLQIAR-QLQKLGVDVIEAGFPITSPGDKEAVSLIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + +D D IKD+ + ++ S HL+ +L + Sbjct 62 REVKG-VVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKLKMDRETVVER 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++ A K + ED S R+ D++ +VE K I +PDT+G PE Sbjct 121 AVAAVKLAKKFTADVEFSAEDAS---RSDLDFLCRVVEAAVKAGATTINIPDTVGYAEPE 177 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + + +++K P + H H+D L+VANSL AI+ G + + +ING+GERAGN Sbjct 178 EFGEFICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTINGIGERAGN 237 Query 244 TPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE +V ++ + + T I I S+LV +G + N+ IVG++ F+ +G Sbjct 238 CSLEEIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKNAFSHESG 297 Query 301 VHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + P G S LGK +G+ ++ E + +LG L+E L + Sbjct 298 IHQDGVLKERTTYEIMNPRLVGIPESRLVLGKHSGRHALKERLLELGYELTEEQLNEAFV 357 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 + L D+ K VT +DL ++ + + E T+ +I +G I P A + L +G+ Sbjct 358 KFKALADKKKEVTDQDLEAMMEEEIRKVPE-TYTLDYFHISTGSTIIPTATVGLIKEGEK 416 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLD 479 ++ + GDG DA A+ KIT G++ P L Y + G+ DAL E + L Sbjct 417 LEDAATGDGPVDAIYKAINKIT---GLT-PVLEQYSINAVTSGE-DALGEVVVKLKNGL- 470 Query 480 LEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + GV D A+ A +N++L +Q Sbjct 471 ---GKIVTGRGVSTDILEASAKAYLNGINKLLFDYQ 503 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bradyrhizobium sp. ORS 278] Sequence ID: A4YZ76.1 Length: 525 Range 1: 11 to 510 Score:179 bits(454), Expect:8e-49, Method:Compositional matrix adjust., Identities:148/522(28%), Positives:245/522(46%), Gaps:35/522(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKLNIA +L + VD +E S G+ E V +I Sbjct 11 RVVIFDTTLRDGEQCPGATMTFEEKLNIAA-MLDDMGVDIIEAGFPIASDGDFEAVNEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + + + G D ++ + I+ + ++ S H++ +L P++ F Sbjct 70 KRSKNAVICG-LSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMDPQQVF-- 126 Query 127 VSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 E I S + + +D WS +G R D++ VE K I +PDT+G Sbjct 127 -----ELVISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDTVGY 181 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 PEE + + + P+ F H HND ++VANS+ +RAG + + +ING+GE Sbjct 182 AVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTINGIGE 241 Query 240 RAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE +V + +DK I+ +T AS++V + + N+ IVG + F Sbjct 242 RAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFA 301 Query 297 QTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K +LPE G K+ S +GK +G+ + ++++G LS ++ Sbjct 302 HESGIHQDGMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLSSNQVE 361 Query 356 KVLERVIELGDQNKLVTPEDLPFIIAD--VSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 R L D+ K + ED+ +I + VS K+L++ ++ +G A ++L Sbjct 362 DAFVRFKALADRKKQIYDEDIEALIDEGMVSAHDRIKLLSL---SVIAGTRGPQRATMKL 418 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRIT 473 + G E SEG+G DA N + + KL Y+V G TDA E + Sbjct 419 DIDGVTRIEESEGNGPVDAVFNCIKSLVPHEA----KLELYQVHAVTEG-TDAQAEVSVR 473 Query 474 WNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + ++ ++ PD VA+ A LN+++ Q Sbjct 474 LS-----QDGRSMTARAADPDTLVASAKAYLGALNKLVMKRQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Heliomicrobium modesticaldum Ice1] Sequence ID: B0TCR1.1 Length: 512 Range 1: 4 to 499 Score:178 bits(451), Expect:1e-48, Method:Compositional matrix adjust., Identities:148/513(29%), Positives:242/513(47%), Gaps:25/513(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ GVS + EKL IA+ L +L VD +E S G+ E V+ + Sbjct 4 RVVIFDTTLRDGEQSPGVSLNLHEKLEIAQ-QLARLGVDVIEAGFPIASPGDFEAVKAVA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 E + + D + + ++ + ++ S H++ +L P + Sbjct 63 EQVRGPVICA-LARANRKDIERAAEALRGAEEARIHTFIATSPIHMQHKLRMEPDKVLDT 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++ A + ED FR+ ++ + + I +PDT+G +P+ Sbjct 122 AVDAVKLAKSFTSNVEFSAED---AFRSDVGFLCRIFSAAIEAGATTINIPDTVGYATPQ 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + ++I P+I H HND L+VAN+L A+ G + +ING+GERAGN Sbjct 179 EFGAFIKAIINGTPNIDKAIVSVHCHNDLGLAVANTLAALENGALQVEGTINGIGERAGN 238 Query 244 TPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE ++ ++ + N +T+IN+ I SRLV +G + N+ IVG++ F +G Sbjct 239 ASLEEVIMALYTRKPFYNLETSINKSEIYRTSRLVSNLTGMLVQPNKAIVGKNAFAHESG 298 Query 301 VHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + PE G + LGK +G+ + E +K+LG L + L K Sbjct 299 IHQDGVLKERTTYEIMNPEMIGIFTNNIVLGKHSGRHAFRERLKELGYSLDDEKLTKAFA 358 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 R L D+ + +T EDL ++ D R + +++ +I SG + P A + L + + Sbjct 359 RFKALADRKREITDEDLVVLVED-ELRAFPEAYSLEYLHITSGTVLVPTATVRLRREEEN 417 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLD 479 +E S GDG DA A+ KIT + +L Y + G+ D+ E S+ Sbjct 418 FEEASCGDGPVDAAYKAIEKITG----TGARLASYAISATTAGE-DSQGEV------SVK 466 Query 480 LEEDQTFKT-MGVHPDQTVAAVHATEKMLNQIL 511 LE + F T GV D VA+ A +N+I+ Sbjct 467 LEREGRFYTGRGVDTDIIVASAKAYLNAVNKIV 499 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pelotomaculum thermopropionicum SI] Sequence ID: A5D4W0.1 Length: 505 Range 1: 4 to 439 Score:178 bits(451), Expect:1e-48, Method:Compositional matrix adjust., Identities:132/442(30%), Positives:218/442(49%), Gaps:13/442(2%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ GVS + EK+ IA+ L KL VD +E S G+ + V +I Sbjct 4 RVYIFDTTLRDGEQSPGVSLNVGEKVQIAR-QLAKLGVDIIEAGFPITSPGDFKAVSEIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + F D ++ + ++ + ++ S HL+ +L + +E Sbjct 63 RQVKGVTVAA-LARANFQDIDRAWEAVRHAEQPRIHTFIATSDIHLKYKLRMSREEVLDA 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++ A + ED S R+ D++ ++ + I +PDT+G PE Sbjct 122 AVAAVKRARAYTGDVEFSAEDAS---RSDLDFLCRVLAAAIEAGATVINIPDTVGYAVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + ++++ K P I H HND ++VANSL A+ G + + +ING+GERAGN Sbjct 179 EWGKFINTIYHKVPGIEKVIVSVHCHNDLGMAVANSLAAVMNGARQVEGAINGIGERAGN 238 Query 244 TPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 +E +V ++ D+ N TNI I S+LV +G ++ N+ +VG++ F AG Sbjct 239 AAIEEMVMALYTRKDQYNLYTNIKTEEIYRTSKLVSALTGMKVQPNKAVVGKNAFAHEAG 298 Query 301 VHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + P G K + LGK +G+ + ++++G LS+ L E Sbjct 299 IHQDGVLKERTTYEIMNPAMVGISKSNLVLGKHSGRHAFRHRLEEMGYNLSDEELNSAFE 358 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 R +L D+ +T EDL II + R T++ +I SG + P A + L+ G++ Sbjct 359 RFKKLADKKMEITDEDLEAIIEE-EMRLVPHTYTLEYLHISSGTTVVPTATVGLKRDGQL 417 Query 420 HKEISEGDGGYDAFMNALTKIT 441 +E + G+G DA A+ KIT Sbjct 418 MEEAACGNGPVDAICKAIDKIT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shouchella clausii KSM-K16] Sequence ID: Q5WEN3.1 Length: 514 Range 1: 3 to 465 Score:178 bits(451), Expect:2e-48, Method:Compositional matrix adjust., Identities:141/480(29%), Positives:223/480(46%), Gaps:31/480(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ + D +LRDGEQ G++ + EKL IA+ L++L VD +E S G+ + V++I Sbjct 3 KINVFDTSLRDGEQMPGIALTVKEKLEIAR-QLERLGVDIIEAGFPASSPGDFQAVKEIA 61 Query 67 EWAATEQLTERIEILGFVDGNKT-VD--W--IKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 E +T G K+ +D W +K S +++ S H+E +L TP Sbjct 62 ETVKGSSIT------GLARAKKSDIDSAWEALKSSAEPRVHVFLATSPIHMEHKLKLTPD 115 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + + YA + + ED + R+ ++K ++E I LPDT+G Sbjct 116 QVVERAVESVRYAAEKFPHVQFSAEDAN---RSEWPFLKRIIEAAIDAGASVINLPDTVG 172 Query 182 VLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 +PEE F+ V ++ H H+D + VANSL AI AG + +ING+G Sbjct 173 YRTPEEISKLFEFVTENVKNIDRAILSTHNHDDLGMGVANSLAAISAGAGQVECTINGIG 232 Query 239 ERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 ERAGN LE + + +S+ +KT + + S LV + + N+ +VG + F Sbjct 233 ERAGNAALEEIAVALQIRSDYYQAKTGLKLSELKRTSALVSRLTSMNVPGNKAVVGANAF 292 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K I PE G S LGK +G+ + + +LG S+ LQ Sbjct 293 AHESGIHQDGMLKNKETYEIITPELVGATSSLPLGKHSGRHAFKTKLNELGFSGSDEKLQ 352 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 + +L D+ K VT +DL +IAD + + + + G+ P A I L+ Sbjct 353 TIFSAFKQLCDKKKEVTEDDLYALIADATDDQDSTAYELTALQVTYGMNHVPTATIRLKK 412 Query 416 QGKIHKEISE---GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 Q +EI E G G +A N L K+T L DY ++ GG+ DAL E + Sbjct 413 QDD--REIEEAGTGSGSVEAIYNTLAKMTG----GNYSLADYRIQSVNGGE-DALAEVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Leptothrix cholodnii SP-6] Sequence ID: B1XYA8.1 Length: 513 Range 1: 4 to 502 Score:177 bits(450), Expect:2e-48, Method:Compositional matrix adjust., Identities:139/513(27%), Positives:241/513(46%), Gaps:23/513(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E V+ I Sbjct 4 QLIIFDTTLRDGEQSPGASMTRDEKLRIAR-QLERLKVDVIEAGFAASSNGDFEAVKAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + + D ++ + ++ + ++ S H+EK+L +P E Sbjct 63 DVIKDSTICS-LARANDRDISRAAEALRGANRARIHTFIATSALHMEKKLRMSPDEVLEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A I ED G+R+ PD++ ++E + E + +PDT+G PE Sbjct 122 ARLSVRFARNLCGDIEFSPED---GYRSDPDFLCRVLEAVIDEGATTLNIPDTVGYAIPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNFIRNLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + + + ++ I ASR+V +G + N+ +VG + F + Sbjct 239 NCSLEEVVMAVKTRRDYFGLDLRVDTSQIVPASRMVAQTTGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + ++ LG+ L SE + Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQDLGIALESEAEVNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 + +L D+ + ED+ +++D + + + + HS +G RPHA++ Sbjct 359 FMKFKDLADRKSEIFDEDILALVSDEQSDNQAEHYRLLALSQHSEMGERPHAEVAFAAGD 418 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 H S+G+G DA + A I +++G +L+ Y V G T++ E + Sbjct 419 VEHHARSDGNGPVDASIKA---IESKVGTG-AELLLYSVNAITSGSTESQGEVTVRLQLG 474 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +G PD VA+ A LN++ Sbjct 475 -----GRIVNGVGADPDIVVASAKAYLAALNKL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Dictyoglomus turgidum DSM 6724] Sequence ID: B8E2W9.1 Length: 503 Range 1: 3 to 497 Score:177 bits(450), Expect:2e-48, Method:Compositional matrix adjust., Identities:155/511(30%), Positives:245/511(47%), Gaps:22/511(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQT GV+ + EKL IAK L KLNVD +E S GE E V+ I Sbjct 3 KLYIFDTTLRDGEQTPGVNLNKEEKLEIAK-QLAKLNVDIIEAGFPIASPGEFEAVKNIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 E + + +D ++ + IK S + ++ S H+EK+L KT E Sbjct 62 EKVKGPIIAALARAIP-MDIDRAWEAIKYSESPRIHTFIATSDIHIEKKLKKTRDEVLEQ 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++YA + + ED R+ +++ + E + + I +PDT+G P Sbjct 121 AVSAVKYAKRYCSDVEFSAED---AVRSDFNFLVKIFEAVIEAGATVINVPDTVGYALPW 177 Query 187 ETFQGVDSLIQKYPDI---HFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + + L + +I H HND L+ ANSL AI G + + ++NGLGERAGN Sbjct 178 EFGELIRRLKENIRNIDKARVSVHCHNDLGLATANSLSAIVNGAEQVECTVNGLGERAGN 237 Query 244 TPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 +E +V I + + +I I + S+LV +G I N+ IVGE+ F +G+H Sbjct 238 AAMEEIVMAIKVRRLPFEVSIKTEEIYKTSKLVSNLTGIPIQPNKAIVGENAFAHESGIH 297 Query 303 ADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 G + I P+ G S LGK +GK + + +++LG L L++ R Sbjct 298 QHGVIQDPSTYEIIDPKTIGIPESKIVLGKHSGKHAFEKRLQELGYSLPPDQLEEAFRRF 357 Query 362 IELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHK 421 EL D+ K +T +D+ ++++ R + ++ + SGIGI P A I + G+ K Sbjct 358 KELADKKKEITDKDIEALVSN-QIRIIPEYYKLRHLQVVSGIGIVPTATIIISENGEEIK 416 Query 422 EISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRIPPGGKTDALVETRITWNKSLDL 480 + G+G DA A+TK + +P L D+ ++ GG TDAL E + L Sbjct 417 TVEIGNGPVDAVYKAITK-----AVKVPHSLEDFSLKSVTGG-TDALGEAMV----KLSD 466 Query 481 EEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 ++ + D A+ A + LNQ++ Sbjct 467 KDGNIYVGRATSTDVIEASALAYLRALNQLV 497 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Synechococcus sp. CC9311] Sequence ID: Q0IBI3.1 Length: 540 Range 1: 1 to 517 Score:178 bits(451), Expect:2e-48, Method:Compositional matrix adjust., Identities:150/535(28%), Positives:246/535(45%), Gaps:42/535(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASPGDFA 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I + E I G ++ D + + + ++ S HLE + Sbjct 60 AVQRIAQQVGGENGPI---ICGLARASRGDIKACADAVAPAPKQRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ K+ V ++ YA + ED R+ P+++ ++E + Sbjct 117 LRKSRKDVLGIVPEMVAYARSFVDDVEFSCEDAG---RSDPEFLYEVIEAAISAGASTVN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + ++ + + P+I HGHND L+VAN L+A+++G + L Sbjct 174 IPDTVGYTTPTEFGRLIEGINRNVPNIDEAVISVHGHNDLGLAVANFLEAVKSGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 ++NG+GERAGN LE LV +H D T + IT+ SRLV Sbjct 234 TVNGIGERAGNAALEELVMAMHVRRRYFNPFFGRDEDSPTPLTAVRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L + G +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + +++LG LS L R +L D+ + +T DL I++ V + + +K Sbjct 354 VRARLEELGYDLSREDLDDAFARFKDLADRKREITDRDLESIVS-VQVQQPDAKYQLKLV 412 Query 398 NIHSGIGIRPHAQIEL-EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV 456 + G ++P A + L + G+ S G G DA +L N+L +L+++ V Sbjct 413 QVSCGSSLQPTATVTLADENGQEQTAASVGTGPVDAVCRSL----NQLAGEPNELVEFSV 468 Query 457 RIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + G DA+ + I + + Q + H D VAA A LN+++ Sbjct 469 KSVTEG-IDAMGDVTIRLRR-----DGQLYSGHSAHTDVVVAAAEAFVNALNRLV 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Variovorax paradoxus S110] Sequence ID: C5CYP2.1 Length: 512 Range 1: 4 to 501 Score:177 bits(450), Expect:2e-48, Method:Compositional matrix adjust., Identities:145/521(28%), Positives:239/521(45%), Gaps:40/521(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L++L VD +E S G+ E V+ I Sbjct 4 QLIIFDTTLRDGEQSPGASMTRDEKMRIAK-QLERLKVDVIEAGFPASSNGDFEAVKAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 + + + + G N D A+ L +G +H H+EK+L Sbjct 63 D------IIKESTVCGLSRAN---DRDISRAAEALKGAARGRIHTFIATSPLHMEKKLRM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 +P E + +A + ED G+R+ PD++ ++E + E I +PD Sbjct 114 SPDEVHEQAKLAVRFARNLVSDVEFSPED---GYRSDPDFLCRVLETVINEGATTINVPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASI 234 T+G PE + L ++ P+ + H HND ++VANSL ++ G + + +I Sbjct 171 TVGYAIPELYGNFIKMLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTI 230 Query 235 NGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NGLGERAGN LE +V + + + NI+ I ASR+V +G + N+ +VG Sbjct 231 NGLGERAGNCSLEEVVMAVKTRRDYFGLDLNIDTTHIVAASRMVSQTTGFVVQPNKAVVG 290 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL- 349 + F +G+H DG K + E G LGKL+G+ + + +++LG+ + Sbjct 291 ANAFAHASGIHQDGVLKARDTYEIMRAEDVGWAANKIVLGKLSGRNAFKQRLQELGVTMA 350 Query 350 SEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 SE + R EL D+ + ED+ +++ ++ S + HS G RP A Sbjct 351 SEADINAAFLRFKELADRKSEIFDEDILALVSAEEHSNVDEQFAFVSLSQHSETGERPQA 410 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 ++ QGK S+G+G DA + A+ S +++ Y V G T++ E Sbjct 411 KVVFTVQGKEVTGESDGNGPVDASLKAIESHVK----SGAEMVLYSVN-AISGSTESQGE 465 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + + + +G PD VA+ A LN++ Sbjct 466 VTVRLQNA-----GRVVNGVGADPDIVVASAKAYLSALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nostoc sp. PCC 7120 = FACHB-418] Sequence ID: P48575.2 Length: 531 Range 1: 1 to 521 Score:178 bits(451), Expect:2e-48, Method:Compositional matrix adjust., Identities:155/537(29%), Positives:241/537(44%), Gaps:38/537(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 MT ++ I D TLRDGEQ G + + EKL IAK L +L VD +E A S G+ E Sbjct 1 MTTKPEKIIIFDTTLRDGEQCPGATLNIDEKLAIAK-QLARLGVDIIEAGFAFASPGDFE 59 Query 61 TVQKIMEWAATEQ--LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGK 118 V KI + T+ + + D + IK + ++ S HL+ +L K Sbjct 60 AVHKIAQTVGTQSGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKK 119 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T E ++ YA + ED R+ P+++ ++E I +PD Sbjct 120 TRPEVIAIAEEMVAYAKSFTDDVEFSPEDAG---RSDPEFLYQVLERAIAAGATTINIPD 176 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +P E + + + P+I HGHND L+VAN L+A++ G + L +IN Sbjct 177 TVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTIN 236 Query 236 GLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSGK 281 G+GERAGN LE LV +H D + TNI+ I + SRLV +G Sbjct 237 GIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEALTNIDTKQIYKTSRLVSNLTGM 296 Query 282 RISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISE 340 + N+ IVG + F +G+H DG K L + + G LGK +G+ + Sbjct 297 LVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRT 356 Query 341 NVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIH 400 +K+LG LSE L K + E+ D+ K ++ DL I+ D + + ++ + Sbjct 357 RLKELGFELSETELNKAFVKFKEVADKKKEISDWDLEAIVND-EIQQAPDLFRVELVQVS 415 Query 401 SGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRI 458 G RP A + L G+ + + G G DA A+ ++ N +P +LI++ V+ Sbjct 416 CGSNARPTATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVN-----VPNQLIEFSVQS 470 Query 459 PPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 G DA+ E I E + F + D VA+ A LN++ Q Sbjct 471 VTAG-IDAIGEVTIRLRY-----ESRVFSGHAANTDIIVASAQAYVNALNRLYASLQ 521 >RecName: Full=2-isopropylmalate synthase; Short=IPMS; AltName: Full=Alpha-isopropylmalate synthase; Short=Alpha-IPM synthase [Saccharolobus solfataricus P2] Sequence ID: Q97W36.2 Length: 386 Range 1: 14 to 375 Score:174 bits(441), Expect:2e-48, Method:Compositional matrix adjust., Identities:113/371(30%), Positives:190/371(51%), Gaps:11/371(2%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ G+ +T +K+ IA+ L L VD +E S+GE +KI Sbjct 14 KIRIFDTTLRDGEQAPGIDLTTEQKIMIAR-KLADLGVDVIEAGFPASSEGEFIATRKIF 72 Query 67 EWAATEQLTERIEILGFVDGNKT-VDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 E ++ +++E++G NK +D +G ++L S H++ +L T +E Sbjct 73 E-----EIGDQVEVIGLSRSNKNDIDKTISTGISSIHLFIATSELHMKYKLKMTKEEVLN 127 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 + ++YA G+ + ED + R D++ + + + +RI +PDT+G + P Sbjct 128 KIYESVKYAKDHGMIVEFSPEDAT---RTEEDFLFTAIRTAIEAGADRINIPDTVGTMHP 184 Query 186 EETFQGVDSLIQKYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 + + + ++ + I H HND+ L+ ANSL + AG + H ++NG+GERAGN Sbjct 185 FKYYDMIKKIVNFVGERIIVSVHCHNDFGLATANSLAGVYAGARQAHVTVNGIGERAGNA 244 Query 245 PLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 LE +V I N +TN+ + E SR V +G + + IVG++ F +G+H Sbjct 245 SLEEVVMGIKKLLNYETNVKTWKLYEVSRFVAEMTGVPVPYFKAIVGDNAFGHESGIHVH 304 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 G + PI PE G R ALGK +G + + +++ G+ LS+ L+ VL + +L Sbjct 305 GVIENPFTYEPISPEEVGNFRRLALGKHSGIHGLRKLLEEQGIYLSDDKLKIVLAEIKKL 364 Query 365 GDQNKLVTPED 375 + VT ED Sbjct 365 AESGNKVTVED 375 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodopseudomonas palustris HaA2] Sequence ID: Q2IUT4.1 Length: 524 Range 1: 9 to 510 Score:177 bits(450), Expect:3e-48, Method:Compositional matrix adjust., Identities:150/525(29%), Positives:239/525(45%), Gaps:37/525(7%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + R+ I D TLRDGEQ G + + EKLN+A+ +L + VD +E S G+ E V + Sbjct 9 QDRVIIFDTTLRDGEQCPGATMTFEEKLNVAR-MLDDMGVDVIEAGYPFASDGDFEAVHE 67 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + + + + D ++ + IK + ++ S H++ +L Sbjct 68 IAKRSKNSVICG-LSRASHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQ------- 119 Query 125 TDVSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 + + V E I S + + +D WS + R D++ +E K I LPDT+ Sbjct 120 MEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTV 179 Query 181 GVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G PEE F+ V + F H HND ++VANS+ + G + + +ING+ Sbjct 180 GYAVPEEYREMFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGI 239 Query 238 GERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE LV + DK NI +T AS+ V + + N+ IVG + Sbjct 240 GERAGNAALEELVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVGRNA 299 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K + PE G K S +GK +G+A + +++LG LS Sbjct 300 FAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKLEELGYKLSRNQ 359 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 ++ V R L D+ K V ED+ ++ D G+ + + S + +G A ++L Sbjct 360 IEDVFVRFKALADRKKDVYDEDIEALV-DEQLLHGQDQIKLNSLTVIAGTHGPQRATMKL 418 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP---KLIDYEVRIPPGGKTDALVET 470 + G+I E +EG+G DA N + + +P KL Y+V G TDA E Sbjct 419 DVDGQIRIEEAEGNGPVDAVFNCIKAL-------VPHDAKLELYQVHAVTEG-TDAQAEV 470 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + + E ++ PD VA+ A LN+I+ Q Sbjct 471 SVRLS-----HEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQ 510 >RecName: Full=2-isopropylmalate synthase; Short=IPMS; AltName: Full=Alpha-isopropylmalate synthase; Short=Alpha-IPM synthase [Sulfurisphaera tokodaii str. 7] Sequence ID: Q974X3.1 Length: 386 Range 1: 11 to 367 Score:174 bits(441), Expect:3e-48, Method:Compositional matrix adjust., Identities:112/366(31%), Positives:189/366(51%), Gaps:10/366(2%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ G+ + +K+ IA+ L + L VD +E S+GE +KI+ Sbjct 11 KVRIFDTTLRDGEQAPGIDLTVEQKVKIARKLAE-LGVDVIEAGFPAASEGEFIATKKIL 69 Query 67 EWAATEQLTERIEILGFVDGNKT-VDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 E ++ +++E++G NK +D D+G +++ S HL+ +L T ++ Sbjct 70 E-----EVGDQVEVIGLSRANKQDIDKTIDTGISSIHVFIATSDIHLKYKLKMTREQVLD 124 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 + + YA GL + ED + R D++ V + +RI +PDT+GV+ P Sbjct 125 KIYESVRYAKDHGLIVEYSPEDAT---RTDKDFLLKAVSTAIEAGADRINIPDTVGVMHP 181 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 + + ++ D H HND+ L+ ANS+ + AG + +H ++NG+GERAGN Sbjct 182 FKFHDLIKDVVSVTKDKIVSVHCHNDFGLATANSIAGVMAGARQVHVTVNGIGERAGNAS 241 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 LE +V + + NI + E SRLV +G + + IVGE+ F AG+H G Sbjct 242 LEEVVMALKKLLGYEVNIKTYKLYETSRLVSELTGVPVPYFKAIVGENAFGHEAGIHVHG 301 Query 306 DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELG 365 + L PI PE G R ALGK +G + + +++ G+ L++ L++VL + +L Sbjct 302 VIENPLTYEPISPEEVGNFRRLALGKHSGIHGLKKLLEEQGIYLNDQELREVLNEIKKLA 361 Query 366 DQNKLV 371 + + V Sbjct 362 ENGEKV 367 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Caulobacter sp. K31] Sequence ID: B0T0G9.1 Length: 524 Range 1: 17 to 447 Score:177 bits(449), Expect:4e-48, Method:Compositional matrix adjust., Identities:134/448(30%), Positives:220/448(49%), Gaps:34/448(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D T+RDGEQ+ G S S EKL +AK +L+++ VD +E S G+ E V++I Sbjct 17 IFDTTMRDGEQSPGASMSHDEKLELAK-ILEEMGVDVIEAGFPIASNGDFEAVREIA--- 72 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 ++ + I G ++ VD D A+ L +G +H H++ +L P Sbjct 73 ---KIVKNSTIAGLCRAHQ-VDI--DRCAEALKGTQRGRIHVVIATSDLHMKHKLQMEPD 126 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 ++ + +A L+ +V +WS + R+ +++ +E K I LPDT Sbjct 127 AVIDVIARSVTHA--RNLRDDV---EWSAEDATRSDRQFLRRAIETAIKAGATTINLPDT 181 Query 180 LGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P E F + ++ + F H HND L+VANSL ++ G + + +ING Sbjct 182 VGYTYPSEYADLFSWMTQNVEGADKVIFSTHCHNDLGLAVANSLAGVQGGARQIECAING 241 Query 237 LGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGN LE +V + DK +T I+ IT ASR V +G + N+ IVG++ Sbjct 242 LGERAGNAALEEVVMALKVRGDKLPYETKIDTTHITRASRYVSAITGFPVQYNKAIVGKN 301 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEV 352 F +G+H DG K + PE G+ S +GK +G + +K LG L + Sbjct 302 AFAHESGIHQDGMLKNRETYEIMTPESVGQAPSSLVMGKHSGSHAFRAKLKDLGYELGQN 361 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 L++ R +L D+ K V +D+ ++ D R E++ ++ + +G + A++ Sbjct 362 ALKEAFGRFKDLADRKKHVYDDDIIALVDDALARGSERI-RVQRLRVVAGTDGQS-AELT 419 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKI 440 LE G++ + GDG DA NA+ +I Sbjct 420 LEVDGEVKTSEASGDGPVDAVFNAIQQI 447 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Paraburkholderia phymatum STM815] Sequence ID: B2JDN6.1 Length: 516 Range 1: 4 to 502 Score:177 bits(448), Expect:5e-48, Method:Compositional matrix adjust., Identities:151/514(29%), Positives:241/514(46%), Gaps:25/514(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L+++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAK-QLERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D + D +K + ++ S H+EK+L +P++ Sbjct 63 GMIKDSTICS-LARANDKDIQRAADALKPADHFRIHTFIATSPLHMEKKLRMSPEQVLEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A K + ED G R+ D++ ++E + E I + DT+G PE Sbjct 122 AKLAVRFARKFTNDVEFSPED---GSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 V +L ++ P+ F H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNLVKTLRERIPNSDKAVFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + + + I+ I AS+LV +G + N+ +VG + F + Sbjct 239 NTSLEEIVMAVRTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGISLDSESELNLA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQIELEYQ 416 +R EL D+ + ED+ I+ + S EK S + HS G RPHA+I + Sbjct 359 FQRFKELADRKAEIFDEDIIAIVTEESAEAQEKEHYKFVSLSQHSETGERPHARIVFSVE 418 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNK 476 GK + G+G DA +NA I +G S +L+ Y V G T A E + +K Sbjct 419 GKEVVGEANGNGPVDATLNA---IETEVG-SGSELLLYSVNAITTG-TQAQGEVTVRLSK 473 Query 477 SLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + + +G PD A+ A LN++ Sbjct 474 A-----GRIVNGVGTDPDIVAASAKAYISALNRL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Synechococcus sp. CC9605] Sequence ID: Q3AIA2.1 Length: 540 Range 1: 1 to 517 Score:177 bits(448), Expect:6e-48, Method:Compositional matrix adjust., Identities:153/535(29%), Positives:243/535(45%), Gaps:42/535(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASPGDFA 59 Query 61 TVQKIMEWAATEQ--LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGK 118 VQ+I + + + + D D + + + ++ S HLE +L K Sbjct 60 AVQRIAQQVGGDNGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRK 119 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + + V ++ YA + ED R+ P+++ ++E I +PD Sbjct 120 SRGDVLGIVPEMVSYARSLVEDVEFSCEDAG---RSDPEFLYEVIEAAIAAGATTINIPD 176 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +P E + + Q P+I HGHND L+VAN L+A++ G + L +IN Sbjct 177 TVGYTTPSEFGALIAGINQHVPNIGEAVISVHGHNDLGLAVANFLEAVKNGARQLECTIN 236 Query 236 GLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSGK 281 G+GERAGN LE LV +H D T + IT+ SRLV +G Sbjct 237 GIGERAGNASLEELVMALHVRRRYYNPFFGREEDSPTPLTAVRTEEITKTSRLVSNLTGM 296 Query 282 RISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISE 340 + N+ IVG + F +G+H DG K L I + G +LGKL+G++++ Sbjct 297 VVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAQTVGLSDNRISLGKLSGRSAVRA 356 Query 341 NVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIH 400 +++LG L+ L + R EL D+ + +T DL I+++ + E +K + Sbjct 357 RLEELGYDLTREDLDEAFARFKELADRKREITDRDLEAIVSE-QVQQPEARFQLKLVQVS 415 Query 401 SGIGIRPHAQIE-LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRI 458 G +RP A + L+ +G + G G DA AL + +P +LI++ V+ Sbjct 416 CGSSLRPTATVTLLDEEGSETTGSAVGTGPVDAVCRALNDLAG-----VPNELIEFSVKS 470 Query 459 PPGGKTDAL--VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 G DA+ V R+ N +L + D VAA A LN+++ Sbjct 471 VTEG-IDAMGDVTIRLRRNGAL-------YSGHAADTDVVVAAGMAFVNALNRLV 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thiobacillus denitrificans ATCC 25259] Sequence ID: Q3SHE7.1 Length: 511 Range 1: 4 to 500 Score:176 bits(446), Expect:8e-48, Method:Compositional matrix adjust., Identities:149/516(29%), Positives:238/516(46%), Gaps:31/516(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 RL I D TLRDGEQ+ G S + EKL IA+ L+KL VD +E A S G+ + ++ I Sbjct 4 RLFIFDTTLRDGEQSPGASMTKDEKLRIAR-QLEKLGVDVIEAGFAAASPGDADAIRAIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 E + + D + IK + + ++ S H+EK+L P + Sbjct 63 ETVRNSTVCS-LARANERDIHAAGGAIKPAKSGRIHTFIATSPIHMEKKLRMQPDQ---- 117 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V+E A+K+ Y +D + R+ D++ + + + K + I +PDT+G Sbjct 118 ---VVEAAVKAVKLAREYTDDVEFSAEDAVRSDMDFLVRIFDEVIKAGAKTINVPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P + + +LI++ P + + H HND ++VANSL A+ G + + +INGLGE Sbjct 175 SIPALWGERMKALIERVPGSDKVIWSTHCHNDLGMAVANSLAAVMNGARQVECTINGLGE 234 Query 240 RAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE +V + + + T I+ I +S+LV +G + N+ IVG + F Sbjct 235 RAGNASLEEIVMAVRTRRDVFGCDTRIDATQIVPSSKLVSTITGYPVQPNKAIVGANAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVL 354 +G+H DG K + E G LGKL+G+ + + +LG+VL SE L Sbjct 295 HESGIHQDGVLKHRETYEIMRAEDVGWNANRLTLGKLSGRNAFKTKLAELGIVLDSEEAL 354 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 R +L D+ + + EDL +++D T ++ + S + S G P AQ+ Sbjct 355 NAAFARFKDLADKKREIFDEDLQALVSDEGYATEDERFKLLSMKVCSETGEVPRAQLVFT 414 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 G + EG G DA AL + + S L+ Y V G TDA E + Sbjct 415 DDGAEKQASGEGSGPVDATFKALESVVH----SGADLLLYSVNNITSG-TDAQGEVTVRL 469 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 ++ + G D VA+ A LN++ Sbjct 470 -----AQDGRVVNGQGADTDIVVASAKAYLHALNKL 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. MIT 9313] Sequence ID: Q7TUV5.1 Length: 540 Range 1: 1 to 487 Score:176 bits(446), Expect:1e-47, Method:Compositional matrix adjust., Identities:142/500(28%), Positives:231/500(46%), Gaps:37/500(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S+G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASQGDFA 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I + + E I G ++ D + + + ++ S HLE + Sbjct 60 AVQRIAQQVGGD---EGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ E V ++ YA + ED + R+ P+++ ++E I Sbjct 117 LRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAA---RSDPEFLYEVIEAAIAAGAGTIN 173 Query 176 LPDTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E G+D + + HGHND L+VAN L+A+++G + Sbjct 174 IPDTVGFTTPSEFGALIAGIDCHVPNMNEAVISVHGHNDLGLAVANFLEAVKSGARQFEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV ++ D T + IT+ SRLV Sbjct 234 TINGIGERAGNAALEELVMALYVRRRYFNPFFGREPDSPTPLTAVRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L + G +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLSDNRISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + +++LG L+ L + R +L D+ + +T DL I+++ ++ E ++ Sbjct 354 VRARLEELGYDLTREDLDEAFARFKDLADRKRDITDRDLEAIVSEQVQQS-EARFQLRLV 412 Query 398 NIHSGIGIRPHAQIELEYQ-GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV 456 + G +RP A + L + G+ + G G DA AL N L +LI++ V Sbjct 413 QVSCGSSLRPTATVILAQEDGQEQTAAAVGTGPVDAVCRAL----NALAGEPNELIEFSV 468 Query 457 RIPPGGKTDALVETRITWNK 476 + G DA+ E I + Sbjct 469 KSVTEG-IDAMGEVTIRLRR 487 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodopseudomonas palustris BisA53] Sequence ID: Q07PI3.1 Length: 521 Range 1: 6 to 510 Score:175 bits(444), Expect:1e-47, Method:Compositional matrix adjust., Identities:147/525(28%), Positives:242/525(46%), Gaps:31/525(5%) Query 2 TKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET 61 T R+ I D TLRDGEQ G + + EKL +A LL + VD +E S G+ E Sbjct 6 TSANDRVIIFDTTLRDGEQCPGATMTFEEKLEVAS-LLDSMGVDVIEAGFPIASDGDFEA 64 Query 62 VQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 V +I + A + + G D ++ + IK + ++ S H++ +L Sbjct 65 VHEIAKRAKNAVICG-LSRAGAKDIDRCAEAIKPAKQGRIHTFLSTSPVHMKYKLQ---- 119 Query 122 EFFTDVSFVIEYAIKSGLKINVYLE--DWS--NGFRNSPDYVKSLVEHLSKEHIERIFLP 177 D + V E I S + + + +WS +G R D++ VE K I +P Sbjct 120 ---MDAAQVYELVISSVTRARNHTDNVEWSSEDGTRTEFDFLCKCVEAAIKAGASTINIP 176 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G PEE + + + P+ F H H+D ++VANSL IR G + + ++ Sbjct 177 DTVGYSVPEEYYDLFKRVRENVPNSDKAIFSVHCHDDLGMAVANSLAGIRGGARQIECTV 236 Query 235 NGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGNT LE +V + +DK I+ +T AS++V + + N+ IVG Sbjct 237 NGIGERAGNTALEEVVMAMKVRNDKLPYWNKIDTTMLTRASKVVSAATSFPVQYNKAIVG 296 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLS 350 + F +G+H DG K +LPE G K+ S +GK +G+ + ++++G L Sbjct 297 RNAFAHESGIHQDGMLKNAETYEIMLPESVGVKQTSLVMGKHSGRHAFIHKLEEMGYKLG 356 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + L+ R L D+ K + ED+ ++ D+ + + S + +G A Sbjct 357 QNQLEDAFVRFKALADRKKDIYDEDIEALV-DLEIAQSHDRIKLVSLTVIAGTHGPQRAT 415 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 ++L+ G+ E +EG+G DA N + + + KL Y+V G TDA E Sbjct 416 MKLDVDGQTKIEEAEGNGPVDAVFNCIKALVPH----VAKLELYQVHAVTEG-TDAQAEV 470 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + + E ++ + PD VA+ A LN+I+ Q Sbjct 471 SVRLS-----HEGRSVTSRASDPDTLVASAKAYLGALNKIVMKRQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Halothermothrix orenii H 168] Sequence ID: B8CX21.1 Length: 515 Range 1: 4 to 504 Score:175 bits(444), Expect:2e-47, Method:Compositional matrix adjust., Identities:153/526(29%), Positives:248/526(47%), Gaps:43/526(8%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI-- 65 ++I D TLRDGEQ+ GVS EKL IAK L ++ VD +E S G+ E VQ I Sbjct 4 VKIFDTTLRDGEQSPGVSLIPEEKLAIAK-QLARMKVDVIEAGFPISSPGDFEAVQIISE 62 Query 66 ----MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 +E AA + ++ D ++ + +++ G +++ S H++ +L + + Sbjct 63 NIRDVEVAALARSRKK-------DIDRAWEALRNGGDPRIHVFIATSPIHMKYKLKLSEE 115 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + ++YA K I ED S R+ P ++ L E + + I +PDT+G Sbjct 116 QVIEKAVEAVKYASKYTSNIEFSAEDAS---RSQPVFLYRLFERVINAGAKVINIPDTVG 172 Query 182 VLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 PEE + + + + H HND L+VANSL A+ G + ++NG+G Sbjct 173 YAIPEEFGKLIRDIKENVSNIDKVDISVHCHNDLGLAVANSLAAVENGANQIEVAVNGIG 232 Query 239 ERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 ERAGNT LE ++ ++ D N N + I S+LV +G I N+ IVG + F Sbjct 233 ERAGNTALEEIIMALYTRKDFYNIGINQDTTQIARLSKLVSNLTGMTIQPNKAIVGANAF 292 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVVL 354 +G+H DG K + G K LGK +G+ + E +++LG + + Sbjct 293 AHESGIHQDGVIKERTTYEIMDARTIGLKDNKLVLGKHSGRHAFREFIQKLGYDIDDETF 352 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 +++ +L D+ K +T ++ +I D T +KV + ++++G + P A I+L+ Sbjct 353 EEIFIEFKKLADKKKNITHVEIEALI-DNHYHTFDKVYELDYLSVNTGNKVLPTATIKLK 411 Query 415 YQGK-IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL----VE 469 + I K GDG DA A+ +I +GI KLI Y + GK DAL V+ Sbjct 412 KENNIIEKAACSGDGPVDAIFQAINEI---VGIDDIKLISYHINAVTEGK-DALGEVIVK 467 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 T+I ED T+ D T A+ A + +N+ L Q Sbjct 468 TKI---------EDNTYTGHSAMTDITEASALAYLETINKFLTSEQ 504 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Synechocystis sp. PCC 6803 substr. Kazusa] Sequence ID: P48576.1 Length: 533 Range 1: 7 to 468 Score:176 bits(445), Expect:2e-47, Method:Compositional matrix adjust., Identities:143/476(30%), Positives:216/476(45%), Gaps:40/476(8%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G + + EKL+IA+ L +L VD +E S G+ E VQKI Sbjct 7 RILIFDTTLRDGEQSPGATLTVEEKLSIAR-ALARLGVDIIEAGFPFASPGDFEAVQKIA 65 Query 67 EWAATEQLTERIEILGFVDGNK------TVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 + TE I G + + ++ L +H LE +L KT Sbjct 66 QTVGTENGPV---ICGLARATQKDIKAAAEALKPAAKHRIHTFLATSDIH-LEHKLKKTR 121 Query 121 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 E V ++ YA I ED R+ P+++ ++E I +PDT+ Sbjct 122 AEVLAIVPEMVAYAKSLVNDIEFSPEDAG---RSDPEFLYQVLEAAISAGATTINIPDTV 178 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G +P E + + P+I HGHND L+VAN L+A++ G + L +ING+ Sbjct 179 GYTTPAEYGALIKGIADNVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGI 238 Query 238 GERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVFSGKRI 283 GERAGN LE LV +H D + TNI+ I SRLV +G + Sbjct 239 GERAGNAALEELVMALHVRRSYFNPFLGRPADSTAPLTNIDTKHIYATSRLVSELTGMMV 298 Query 284 SANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENV 342 N+ IVG + F +G+H DG K L + E G LGKL+G+ + + Sbjct 299 QPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRNAFGTRL 358 Query 343 KQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSG 402 K+LG LS+ L R E+ D+ K +T DL I+ D R ++ ++ + G Sbjct 359 KELGFDLSDTELNNAFIRFKEVADKRKEITDWDLEAIVND-EIRQPPELFRLERVQVSCG 417 Query 403 IGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEV 456 P A + + G ++ G G DA A+ +I + +P +L++Y V Sbjct 418 EPSVPTATLTIRTPAGPEETAVAIGTGPVDAVYKAINQI-----VQLPNELLEYSV 468 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus subsp. pastoris str. CCMP1986] Sequence ID: Q7V121.1 Length: 546 Range 1: 1 to 464 Score:176 bits(446), Expect:2e-47, Method:Compositional matrix adjust., Identities:144/470(31%), Positives:222/470(47%), Gaps:32/470(6%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+K R+ I D TLRDGEQ+ G S + EKL IA L +L VD +E S G+ + Sbjct 1 MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAH-QLARLGVDVIEAGFPFASPGDFK 59 Query 61 TVQKIMEWAATEQ--LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGK 118 V KI E E + + D + I + K ++ S HL+ +L K Sbjct 60 AVNKIAEVVGGENGPIICGLARASTNDIKACYEAISPAPKKRIHTFIATSDIHLKHKLRK 119 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T + V ++ YA I ED S R+ P+++ +++ I +PD Sbjct 120 TRSDVLCIVPEMVSYAKSLVDDIEFSCEDAS---RSDPEFLYEVIQLAITSGATTINIPD 176 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +P E + + + + P+I HGHND L+VAN L+A + G + L +IN Sbjct 177 TVGFTTPSEFGKLIFDINKNVPNIDEAIISVHGHNDLGLAVANFLEAAKNGARQLECTIN 236 Query 236 GLGERAGNTPLEALVTTIHDK-----------SNSKTNINEI---AITEASRLVEVFSGK 281 G+GERAGN LE LV +H + S+S T + I IT+ SRLV +G Sbjct 237 GIGERAGNASLEELVMALHVRKSFFNSFFGRSSDSPTPLTAIRTEEITKTSRLVSNLTGM 296 Query 282 RISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISE 340 + N+ IVG + F +G+H DG K L I + G +LGKL+G++++ Sbjct 297 NVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLNDNKISLGKLSGRSAVRA 356 Query 341 NVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIH 400 ++++G LS L R EL D+ + +T DL I+++ + E + + Sbjct 357 RLEEMGYDLSREDLNDAFARFKELADRKREITDRDLEAIVSE-QVQLPESKFQLSHVQVS 415 Query 401 SGIGIRPHAQIELEYQGKIHKE---ISEGDGGYDAF---MNALTKITNRL 444 G +P A + L + H E ++ G G DA +NALTK+ N L Sbjct 416 CGSTSKPTATVTL-INTEDHTEDTAVAIGTGPVDAVCEALNALTKVPNEL 464 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Caulobacter vibrioides NA1000] Sequence ID: B8H607.1 Length: 524 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Caulobacter vibrioides CB15] Sequence ID: Q9A823.1 Length: 524 Range 1: 17 to 447 Score:175 bits(444), Expect:2e-47, Method:Compositional matrix adjust., Identities:132/440(30%), Positives:213/440(48%), Gaps:18/440(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 + D T+RDGEQ+ G S S EKL +AK +L+++ VD +E S G+ E V++I E Sbjct 17 VFDTTMRDGEQSPGASMSLEEKLELAK-ILEEMGVDVIEAGFPIASNGDFEAVRQIAELI 75 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 TE + D ++ + ++ + ++ S H++ +L P ++ Sbjct 76 -TESTVCGLARAAAGDIDRCAEAVRRAKRGRIHTFISTSPVHMKYKLQMEPDAVLEAITR 134 Query 130 VIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 + +A L +V +WS + R D++K VE K I LPDT+G P E Sbjct 135 SVSHA--RNLVGDV---EWSAEDATRTERDFLKRCVEAAIKAGATTINLPDTVGYSYPSE 189 Query 188 TFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 + +I P F H HND L+VANS+ AI G + + +ING+GERAGN Sbjct 190 YGELFRDVITSVPGADKAIFSAHCHNDLGLAVANSIAAIEGGARQVEVAINGIGERAGNA 249 Query 245 PLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 LE +V + + + T+++ + IT ASR V +G + N+ IVG++ F +G+ Sbjct 250 ALEEIVMALRVRGDHLPYGTSVDPVHITRASRYVSAITGFPVQFNKAIVGKNAFAHESGI 309 Query 302 HADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLER 360 H DG K + PE G+ + +GK +G+ + E +K LG L + L R Sbjct 310 HQDGMLKNAETYEIMKPEDVGQGATNLVMGKHSGRHAFREKLKALGYELGQNALNDAFGR 369 Query 361 VIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIH 420 EL D+ K V +D+ ++ D R EK+ + + +G + A++ L+ G Sbjct 370 FKELADKKKHVFDDDIVALVDDALARGSEKI-RVSRLRVVAGTDGQS-AELTLDIDGVAS 427 Query 421 KEISEGDGGYDAFMNALTKI 440 + GDG DA NA+ KI Sbjct 428 TAEATGDGPVDAVFNAIHKI 447 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. MIT 9303] Sequence ID: A2C859.1 Length: 540 Range 1: 1 to 487 Score:176 bits(445), Expect:2e-47, Method:Compositional matrix adjust., Identities:143/500(29%), Positives:234/500(46%), Gaps:37/500(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S+G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASQGDFS 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I + + E I G ++ D + + + ++ S HLE + Sbjct 60 AVQRIAQQVGGD---EGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ E V ++ YA + ED + R+ P+++ ++E I Sbjct 117 LRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAA---RSDPEFLYEVIEAAIAAGAGTIN 173 Query 176 LPDTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E G+D + + HGHND L+VAN L+A+++G + Sbjct 174 IPDTVGFTTPSEFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFEC 233 Query 233 SINGLGERAGNTPLEALVTTIHDK-----------SNSKTNINEI---AITEASRLVEVF 278 +ING+GERAGN LE LV ++ + S+S T + + IT+ SRLV Sbjct 234 TINGIGERAGNAALEELVMALYVRRRYFNPFFGRESDSPTPLTAVRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L + G +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + +++LG L+ L + R +L D+ + +T DL I+++ + E ++ Sbjct 354 VRARLEELGYDLTREDLDEAFARFKDLADRKRDITDRDLEAIVSE-QVQQPEARFQLRLV 412 Query 398 NIHSGIGIRPHAQIELEYQ-GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV 456 + G +RP A + L + G+ + G G DA AL N L +LI++ V Sbjct 413 QVSCGSSLRPTATVILAQEDGQEQTAAAVGTGPVDAVCRAL----NALAGEPNELIEFSV 468 Query 457 RIPPGGKTDALVETRITWNK 476 + G DA+ E I + Sbjct 469 KSVTEG-IDAMGEVTIRLRR 487 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Parabacteroides distasonis ATCC 8503] Sequence ID: A6LDN1.1 Length: 500 Range 1: 4 to 498 Score:174 bits(442), Expect:2e-47, Method:Compositional matrix adjust., Identities:141/522(27%), Positives:236/522(45%), Gaps:44/522(8%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV---Q 63 RL I D TLRDGEQ G +T EK+ +AK L++L VD +E S G+ ++V Sbjct 4 RLFIFDTTLRDGEQVPGCQLNTVEKIQVAK-ALEQLGVDVIEAGFPVSSPGDFKSVVEIS 62 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 K + W LT +E K +D A+ L +G +H H++ + Sbjct 63 KAVTWPTICALTRAVE--------KDIDV----AAEALRFAKRGRIHTGIGTSDSHIKYK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 T +E +YA K + Y ED R +Y+ +VE + K + Sbjct 111 FNSTREEIIERAIAATKYAKKYVEDVEFYCEDAG---RTDNEYLARVVEAVIKAGATVVN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT G P+E + L++ +H H HND ++ AN++Q + G + + Sbjct 168 IPDTTGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEV 227 Query 233 SINGLGERAGNTPLE--ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 +ING+GERAGNT LE A+V H + + TNI I SR+V + N+ IV Sbjct 228 TINGIGERAGNTSLEEVAMVFKSHKERDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIV 287 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL 349 G + F ++G+H DG K I P+ G + L +G+A++ + LG+ L Sbjct 288 GRNAFAHSSGIHQDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRLHVLGVDL 347 Query 350 SEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 + L KV + ++L D+ K + +D+ ++ RT + ++ + SG+G++ A Sbjct 348 EQEKLDKVYDEFLKLADRKKDINDDDVLMLVG--KDRTATHRIKLEYLQVTSGVGVQSVA 405 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 I L G E + G+G DA + A+ K + ++I + + I G V Sbjct 406 SICLNLSGVRRYEAAAGNGPVDAGIKAVKKAISNSDMTIQEFLIQA--INKGSDDTGKVH 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 ++ +N + T+ + D A+V A +N+ + Sbjct 464 MQVEYNGA-------TYYGFSANTDIIAASVEAFVDAINKFI 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. MIT 9215] Sequence ID: A8G5D5.1 Length: 546 Range 1: 1 to 484 Score:175 bits(443), Expect:3e-47, Method:Compositional matrix adjust., Identities:150/498(30%), Positives:231/498(46%), Gaps:40/498(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+K R+ I D TLRDGEQ+ G S + EKL IA L +L VD +E S G+ + Sbjct 1 MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAH-QLARLGVDVIEAGFPFASPGDFK 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 V KI E I G +K + + + K ++ S HL+ + Sbjct 60 AVNKIANSVGKENGPI---ICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ K+ V ++ YA I ED S R+ PD++ +++ I Sbjct 117 LKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDAS---RSDPDFLYEVIQLAISAGATTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + + + + P+I HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGFTTPNEFGKLISDINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIHDK-----------SNSKTNINEI---AITEASRLVEVF 278 +ING+GERAGN LE LV +H + S+S T + I IT+ SRLV Sbjct 234 TINGIGERAGNASLEELVMALHVRKSFFNKFFNRNSDSPTPLTAIRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L I + G +LGKL+G+++ Sbjct 294 TGMIVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + ++++G LS L R +L D+ + +T DL I+++ + E + Sbjct 354 VRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEAKFQLSLV 412 Query 398 NIHSGIGIRPHAQIEL--EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDY 454 + G +P A I L +S G G DA AL K+ +P +LI++ Sbjct 413 QVSCGNASKPTATISLINTEDNSEDTAVSIGTGPVDAVCEALNKLA-----KVPNELIEF 467 Query 455 EVRIPPGGKTDALVETRI 472 V+ G DAL E I Sbjct 468 SVKSVTEG-IDALGEVTI 484 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. AS9601] Sequence ID: A2BRP4.1 Length: 546 Range 1: 1 to 484 Score:175 bits(443), Expect:3e-47, Method:Compositional matrix adjust., Identities:149/498(30%), Positives:227/498(45%), Gaps:40/498(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+K R+ I D TLRDGEQ+ G S + EKL IA L +L VD +E S G+ + Sbjct 1 MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAH-QLARLGVDVIEAGFPFASPGDFK 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 V KI E I G +K + + + K ++ S HL+ + Sbjct 60 AVNKIANAVGKENGPI---ICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ K+ V ++ YA I ED S R+ PD++ +++ I Sbjct 117 LKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDAS---RSDPDFLYEVIQLAISAGATTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + + + P+I+ HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGFTTPSEFGNLIADINKNVPNINEAVISVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV +H D T I IT+ SRLV Sbjct 234 TINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L I + G +LGKL+G+++ Sbjct 294 TGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + ++++G LS L R +L D+ + +T DL I+++ + E + Sbjct 354 VRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEAKFQLSLV 412 Query 398 NIHSGIGIRPHAQIEL--EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDY 454 + G +P A I L +S G G DA AL K+ +P +LI++ Sbjct 413 QVSCGNASKPTATISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLA-----KVPNELIEF 467 Query 455 EVRIPPGGKTDALVETRI 472 V+ G DAL E I Sbjct 468 SVKSVTEG-IDALGEVTI 484 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. MIT 9312] Sequence ID: Q31AF9.1 Length: 546 Range 1: 1 to 484 Score:175 bits(443), Expect:4e-47, Method:Compositional matrix adjust., Identities:149/498(30%), Positives:229/498(45%), Gaps:40/498(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+K R+ I D TLRDGEQ+ G S + EKL IA L +L VD +E S G+ + Sbjct 1 MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAH-QLARLGVDVIEAGFPFASPGDFK 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 V KI E I G +K + + + K ++ S HL+ + Sbjct 60 AVNKISNDVGKENGPI---ICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ K+ V ++ YA I ED S R+ PD++ +++ I Sbjct 117 LKKSRKDVLQIVPEMVNYAKTLVEDIEFSCEDAS---RSDPDFLYEVIQLAISAGATTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + + + + P+I HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGFTTPSEFGKLISDINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV +H D T I IT+ SRLV Sbjct 234 TINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L I + G +LGKL+G+++ Sbjct 294 TGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + ++++G LS L R +L D+ + +T DL I+++ + E + Sbjct 354 VRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEAKFQLCLV 412 Query 398 NIHSGIGIRPHAQIELEYQGKIHKE--ISEGDGGYDAFMNALTKITNRLGISIP-KLIDY 454 + G +P A I L ++ +S G G DA AL K+ +P +LI++ Sbjct 413 QVSCGNASKPTATITLLNTADNTEDTAVSVGTGPVDAVCEALNKLA-----KVPNELIEF 467 Query 455 EVRIPPGGKTDALVETRI 472 V+ G DAL E I Sbjct 468 SVKSVTEG-IDALGEVTI 484 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia lata] Sequence ID: Q39ED5.1 Length: 514 Range 1: 4 to 502 Score:174 bits(440), Expect:5e-47, Method:Compositional matrix adjust., Identities:151/519(29%), Positives:242/519(46%), Gaps:35/519(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L +++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAKHL-ERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 L + I N + D +K + + ++ S H+EK+L TP Sbjct 63 ------GLIKDSTICSLARANDKDIQRAADALKPAESFRIHTFIATSPLHMEKKLRMTPD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + F + +A K + ED G R+ D++ ++E + E I + DT+G Sbjct 117 QVFEQARLAVRFARKFTDNVEFSPED---GSRSDMDFLCRVLEAVIAEGATTINIADTVG 173 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGL 237 PE V +L ++ P+ F H HND ++VANSL ++ G + + +INGL Sbjct 174 YGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGNT LE +V + + + I+ I S+LV +G + N+ +VG + Sbjct 234 GERAGNTSLEEIVMAVKTRKDYFGLDVGIDTSQIVPTSKLVSQITGFVVQPNKAVVGANA 293 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEV 352 F +G+H DG K + E G LGKL+G+ + + +++LG+ L SE Sbjct 294 FAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSES 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQI 411 L R +L D+ + ED+ I+++ S E+ S + HS G +PHA++ Sbjct 354 ELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAHEQEHFKFVSLSQHSETGEQPHAKV 413 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETR 471 +GK + G+G DA NA I + +G S +L+ Y V G T A E Sbjct 414 VFGVEGKEVTGEARGNGPVDATFNA---IESEVG-SGSELLLYSVNAITTG-TQAQGEVT 468 Query 472 ITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +KS + +G PD A+ A LN++ Sbjct 469 VRLSKS-----GRIVNGVGTDPDIVAASAKAYISALNKL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bradyrhizobium sp. BTAi1] Sequence ID: A5EP79.1 Length: 523 Range 1: 11 to 510 Score:174 bits(441), Expect:5e-47, Method:Compositional matrix adjust., Identities:150/523(29%), Positives:244/523(46%), Gaps:37/523(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKLNIA +L + VD +E S G+ E V +I Sbjct 11 RVVIFDTTLRDGEQCPGATMTFEEKLNIAA-MLDGMGVDVIEAGFPIASDGDFEAVNEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + + G D ++ + I+ + ++ S H++ +L P+ F Sbjct 70 KRTQNAVVCG-LSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMEPQAVF-- 126 Query 127 VSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 E + S + + +D WS +G R D++ VE K I +PDT+G Sbjct 127 -----ELVVSSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGATTINIPDTVGY 181 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 PEE + + + P+ F H HND ++VANS+ IRAG + + +ING+GE Sbjct 182 AVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGIRAGARQIECTINGIGE 241 Query 240 RAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE +V + +DK I+ +T AS++V + + N+ IVG + F Sbjct 242 RAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFA 301 Query 297 QTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K +LPE G K+ S +GK +G+ + ++++G L+ ++ Sbjct 302 HESGIHQDGMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLAGNQVE 361 Query 356 KVLERVIELGDQNKLVTPEDLPFIIAD--VSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 R L D+ K + ED+ +I + VS K+L++ ++ +G A ++L Sbjct 362 DAFVRFKALADRKKHIYDEDIEALIDEGMVSAHDRIKLLSL---SVIAGTRGPQRATMKL 418 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRIT 473 + G E SEG+G DA N + + KL Y+V G TDA E Sbjct 419 DVDGVTKIEESEGNGPVDAVFNCIKSLVPHEA----KLELYQVHAVTEG-TDAQAEV--- 470 Query 474 WNKSLDLEED-QTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 S+ L +D ++ PD VA+ A LN+++ Q Sbjct 471 ---SVRLSQDGRSMTARAADPDTLVASAKAYLGALNKLVMKRQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodoferax ferrireducens T118] Sequence ID: Q21VZ1.1 Length: 512 Range 1: 4 to 438 Score:174 bits(440), Expect:6e-47, Method:Compositional matrix adjust., Identities:131/440(30%), Positives:208/440(47%), Gaps:14/440(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ E VQ I Sbjct 4 QLIIFDTTLRDGEQSPGASMNKDEKLRIAR-QLERLKVDVIEAGFAASSNGDFEAVQGIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + + D ++ + +K + ++ S H+EK+L TP + F Sbjct 63 R-AIKDSTICSLSRANDRDISRAAEALKGANRSRIHTFIATSALHMEKKLRMTPDQVFEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A + ED +R+ D++ ++E E I +PDT+G PE Sbjct 122 AKLAVRFARNLVADVEFSPED---AYRSDEDFLCRVIEAAINEGATTINVPDTVGYAIPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 + +L ++ P+ + H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGTFIKTLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE +V + + + +I I ASR+V +G + N+ IVG + F A Sbjct 239 NCSLEEVVMAVKTRRDYFGLDVDIETQHILAASRMVSQITGFVVQPNKAIVGANAFAHAA 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G L K++G+ + + ++ LG + SE + Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWSANKIVLSKVSGRNAFKQRLQDLGAQMESESDVNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 R EL D+ + ED+ ++ S ++ + S + HS G RP A I G Sbjct 359 FARFKELADRKSEIFDEDILALVGSESVAREKEQYSFVSLSQHSETGERPQASIVFTADG 418 Query 418 KIHKEISEGDGGYDAFMNAL 437 K K S+GDG DA + A+ Sbjct 419 KEVKSSSDGDGPVDASLKAI 438 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Candidatus Vesicomyidisocius calyptogenae] Sequence ID: A5CWZ3.1 Length: 511 Range 1: 4 to 501 Score:173 bits(439), Expect:7e-47, Method:Compositional matrix adjust., Identities:150/519(29%), Positives:240/519(46%), Gaps:35/519(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK +L+K+ VD +E A S+G+ E VQ + Sbjct 4 KLIIFDTTLRDGEQSPGASMTKDEKIRIAK-VLEKMKVDVIEAGFAIASEGDFEAVQAVA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + L D ++ + +K + A ++ S H++ +L TP + Sbjct 63 NIVQNSVICSLARALD-KDIDRAGEALKGANASRIHTFIATSNIHMKMKLQMTPDQ---- 117 Query 127 VSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V+ A+++ + N Y ++ + R+ D++ ++E + K I +PDT+G Sbjct 118 ---VVGQAVRAVKRANRYTDNIEFSPEDAGRSDEDFLCYIIEAVIKAGATTINIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P + + SLI++ P+ F H HND L+VANSL A+ G + + +INGLGE Sbjct 175 NIPHQFGATIKSLIERIPNSDKAIFSAHCHNDLGLAVANSLSAVLNGARQVECTINGLGE 234 Query 240 RAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGNT LE LV + D + TNI+ + I ASRL +G I N+ IVG + F Sbjct 235 RAGNTSLEELVMAVRTRQDIFDCDTNIDTMHILSASRLASSVTGFIIQPNKAIVGANAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEV-VL 354 AG+H DG K + E G LGK +G+ + + +LG+ ++ L Sbjct 295 HEAGIHQDGVLKHRETYEIMRAEDVGWNANQLVLGKHSGRNAFKVRLAKLGVEFNDDGSL 354 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 R EL D+ + EDL ++++ + ++ + + S + + + A + L Sbjct 355 NDAFRRFKELADKKHEIFDEDLQALVSETQTESCDEAIKLVSLKVCTETNEKNTATVVLF 414 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRI 472 K + G DA +A+ N L L Y V G TDAL V R+ Sbjct 415 INDKKKTATANTSGAVDATFSAI----NSLASIKINLQLYSVSNVTQG-TDALGEVNVRL 469 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 +N + GV D A+ A LN++L Sbjct 470 EYNGRI-------VNGQGVDTDIITASAKAYVHGLNKVL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Polynucleobacter asymbioticus QLW-P1DMWA-1] Sequence ID: A4SXR0.1 Length: 515 Range 1: 7 to 506 Score:173 bits(439), Expect:7e-47, Method:Compositional matrix adjust., Identities:149/517(29%), Positives:244/517(47%), Gaps:28/517(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ+ G S + EK+ IA+ L++L VD +E A S+G+ + + + A Sbjct 7 IFDTTLRDGEQSPGASMTKDEKVRIAR-QLERLKVDVIEAGFAASSEGDFQAISAVAA-A 64 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 + + + D + D ++ + AK ++ S H+ +L +P+E Sbjct 65 VKDSIVCSLARANDKDITRAADALQAANAKRIHAFLATSPLHMAVKLRMSPEEVLEQAKR 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 I +A I ED G+R+ D++ +VE + E I +PDT+G +PE Sbjct 125 SIRFARNLASDIEFSAED---GYRSEMDFLCRVVEAVINEGASTINIPDTVGYATPELYG 181 Query 190 QGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAGNTP 245 + +L + P+ + H HND ++VANSL ++ G + + +INGLGERAGNT Sbjct 182 DFIKTLRTRVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTA 241 Query 246 LEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 LE +V + D + I+ I AS+LV +G + N+ +VG + F T+G+H Sbjct 242 LEEIVMALRTRKDYFDMVCGIDASQIVPASKLVSQITGFVVQPNKAVVGANAFAHTSGIH 301 Query 303 ADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGM-VLSEVVLQKVLER 360 DG K + E G LGKL+G+ + + +++LG+ V +E L + R Sbjct 302 QDGILKNRDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGITVEAEADLNEAFTR 361 Query 361 VIELGDQNKLVTPEDLPFIIAD-VSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 L DQ + ED+ I++D + GE I S + HS G RP +++ K Sbjct 362 FKALADQKSEIFDEDIIAIMSDSAAAEEGEHYHFI-SLSQHSETGERPKSRVIFRMGDKE 420 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTDALVETRITWNKSL 478 +EG+G DA +NA+ +I S + + Y V I G ++ V R++ + Sbjct 421 VSSEAEGNGPVDASLNAIEEIAK----SGAEQLLYSVNAITSGTQSQGEVTVRLSKGGRI 476 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 +G PD A+ A LN++ P Q Sbjct 477 -------VNGVGTDPDIIAASAKAYLSALNKLHDPSQ 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Neisseria meningitidis MC58] Sequence ID: Q9JZG1.1 Length: 517 Range 1: 6 to 442 Score:173 bits(439), Expect:7e-47, Method:Compositional matrix adjust., Identities:133/449(30%), Positives:214/449(47%), Gaps:27/449(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G + + EK+ +A+ L+KL VD +E A S G+ E V I Sbjct 6 RVIIFDTTLRDGEQSPGAAMTKEEKIRVAR-QLEKLGVDIIEAGFAAASPGDFEAVNAIA 64 Query 67 EW---AATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 + + L+ IE D + + + + K ++ S H+E +L PK+ Sbjct 65 KTITKSTVCSLSRAIE----RDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQ- 119 Query 124 FTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 VIE A+K+ Y +D + R+ D++ + + + I +PDT Sbjct 120 ------VIEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDT 173 Query 180 LGVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P +T + LI K P+ + + H HND L+VANSL A++ G + + ++NG Sbjct 174 VGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNG 233 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGN +E +V + HD +T I+ I +S+LV +G + N+ IVG + Sbjct 234 LGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGAN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SE 351 F+ +G+H DG K + E G +LGKL+G+ + + LG+ L SE Sbjct 294 AFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESE 353 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L R EL D+ + + EDL +++D G + S I + G P A I Sbjct 354 EALNAAFARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADI 413 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKI 440 +G+ + + G G DA A+ + Sbjct 414 VFSIKGEEKRASATGSGPVDAIFKAIESV 442 >RecName: Full=2-isopropylmalate synthase; Short=IPMS; AltName: Full=Alpha-isopropylmalate synthase; Short=Alpha-IPM synthase [Sulfolobus acidocaldarius DSM 639] Sequence ID: Q4JA78.1 Length: 386 Range 1: 11 to 371 Score:170 bits(431), Expect:8e-47, Method:Compositional matrix adjust., Identities:109/370(29%), Positives:186/370(50%), Gaps:10/370(2%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ G+ + +K+ +AK L + L VD +E S GE E +KI+ Sbjct 11 KVRIFDTTLRDGEQAPGIDLTVDQKIRVAKRLAE-LGVDVIEAGFPASSDGEFEATKKIL 69 Query 67 EWAATEQLTERIEILGFVDGNKT-VDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 ++ +++E+ G K +D D+G +++ S HL+ +L T +E Sbjct 70 S-----EIGDQVEVTGLSRSVKQDIDRTIDTGLSSIHIFIATSDIHLKYKLKMTREEVLN 124 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 + + YA GL + ED + R+ +++ V+ +RI +PDT+GV+ P Sbjct 125 RIYESVRYAKDHGLIVEYSPEDAT---RSDEEFLLKAVKTAIDAGADRINIPDTVGVMHP 181 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 + + + +++ D H HND+ L+ ANS+ + AG + +H ++NG+GERAGN Sbjct 182 FKFYDLISKIVKVTGDKIVSVHCHNDFGLATANSIAGVMAGARQVHVTVNGIGERAGNAS 241 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 LE +V ++ + + E SR V +G + + IVGE+ F AG+H G Sbjct 242 LEEVVMSLKKLLGYDVGVRTYLLYEVSRYVAELTGVPVPYFKAIVGENAFGHEAGIHVHG 301 Query 306 DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELG 365 + + PI PE G R ALGK +G + +++ G+ L + L++VL+ + L Sbjct 302 VIENPMTYEPISPEEVGNFRRIALGKHSGIHGLKRLLEEQGIFLDDTQLREVLKEIKSLA 361 Query 366 DQNKLVTPED 375 + VT D Sbjct 362 EAGNKVTSAD 371 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Listeria welshimeri serovar 6b str. SLCC5334] Sequence ID: A0AK92.1 Length: 512 Range 1: 3 to 491 Score:173 bits(439), Expect:8e-47, Method:Compositional matrix adjust., Identities:146/507(29%), Positives:243/507(47%), Gaps:29/507(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 +++ D TLRDGEQT GV+F EK+ IA L+KL +D +E S G+ E V+ I Sbjct 3 KIQFFDTTLRDGEQTPGVNFDVKEKIQIA-LQLEKLGIDVIEAGFPISSPGDFECVRAIA 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ + L +E G +D + + +K++ + +++ S H+E +L + E Sbjct 62 KAIKHCSVTGLARCVE--GDID--RAEEALKEAVSPQIHIFLATSDVHMEYKLKMSRAEV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + I YA + + ED + R+ ++ V+ I +PDT+G Sbjct 118 LASIKHHIHYARQKFDIVQFSPEDAT---RSDRAFLIEAVQTAIDAGATVINIPDTVGYT 174 Query 184 SPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +P E FQ + I+++ DI F H H+D ++ AN+L AI G + + +ING+GER Sbjct 175 NPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGER 234 Query 241 AGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE + +H D ++TNI +S L+ SG + N+ ++G + + Sbjct 235 AGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAH 294 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I P G K S LGKL+GK + ++++G LSE L+ Sbjct 295 ESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFHTRMEEMGYTLSEQELKD 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 +R +L D K VT EDL +I S + + +K + G A + +E + Sbjct 355 TFKRFKQLADAKKEVTEEDLHALILGQSSESTDN-FELKHLQVQYVSGGVQGAIVRIEER 413 Query 417 -GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 G + ++ + G G +A N + NRL +LIDY ++ G+ DA E + Sbjct 414 DGALIEDAATGSGSIEAIYNTI----NRLMKQDIELIDYRIQAITAGQ-DAQAEVHVVIK 468 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHA 502 + + E F +G+ D A+ A Sbjct 469 DNNETE----FHGIGIDFDVLTASAKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pyrococcus abyssi GE5] Sequence ID: Q9UZ08.1 Length: 486 Range 1: 3 to 460 Score:172 bits(437), Expect:8e-47, Method:Compositional matrix adjust., Identities:150/479(31%), Positives:233/479(48%), Gaps:37/479(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQT GVS + EK+ IAK L KLNVD +E S+GE + V+KI Sbjct 3 KVYIFDTTLRDGEQTPGVSLTVEEKVEIAK-QLAKLNVDVIEAGFPIASEGEFKAVKKI- 60 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 ATE I L + V+ D + L K +H H++ +L K Sbjct 61 ---ATEVEDPTIAALA-----RAVEKDIDRAGEALRNAEKNRIHTFIATSPIHMKYKLRK 112 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 P+E +E+A K + ED + R+ D++ + E + I +PD Sbjct 113 EPEEVKKLAVKAVEHATKYTEDVEFSAEDAT---RSDWDFLVEVYEAVIDAGATVINVPD 169 Query 179 TLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +PEE ++ V L I + H H+D L+VANSL AIRAG + ++N Sbjct 170 TVGYATPEEFYELVRYLRRNISNIKGVQISVHCHDDLGLAVANSLSAIRAGADQVEVTVN 229 Query 236 GLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE ++ + D KT++N I S+LV +G + N+ IVG Sbjct 230 GIGERAGNAALEEVIVALDVRRDFYKVKTDVNLKEIARTSKLVSHLTGIEVPPNKAIVGG 289 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F +G+H DG K I P++ G S LGK +G+ + + +++LG L+E Sbjct 290 NAFAHESGIHQDGVLKERTTYEIIDPKKLGFSGSKIVLGKHSGRHAFRKKLEELGYSLTE 349 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L++ ++ ++ D+ + +T D+ II + ++ K +K IH G A + Sbjct 350 EHLERAFKKFKDIADRKRWITDTDIEAIIQEELTKSNGK---LKVEIIHVTSGKVSTATV 406 Query 412 ELEYQGKIHKEISE-GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + G+ E++ +G DA +A+ K LG KL +Y V GK D+L E Sbjct 407 RISMNGEERIEVAWFKNGPIDALFSAINKA---LGEEF-KLREYRVSSVTSGK-DSLGE 460 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodopseudomonas palustris TIE-1] Sequence ID: B3QCX5.1 Length: 524 Range 1: 9 to 510 Score:173 bits(439), Expect:9e-47, Method:Compositional matrix adjust., Identities:148/525(28%), Positives:238/525(45%), Gaps:37/525(7%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + R+ I D TLRDGEQ G + + EKLN+A+ +L + VD +E S G+ E V + Sbjct 9 QDRVIIFDTTLRDGEQCPGATMTFEEKLNVAR-MLDDMGVDVIEAGYPFASDGDFEAVHE 67 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + + + + D ++ + IK + ++ S H++ +L Sbjct 68 IAKRSKNSVICG-LSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQ------- 119 Query 125 TDVSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 + + V E I S + + +D WS + R D++ +E K I LPDT+ Sbjct 120 MEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTV 179 Query 181 GVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G PEE F+ V + F H HND ++VANS+ + G + + +ING+ Sbjct 180 GYAVPEEYRELFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGI 239 Query 238 GERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE +V + DK I +T AS+ V + + N+ IVG + Sbjct 240 GERAGNAALEEVVMAMRVRQDKLPYWNRIETTMLTHASKTVSAATSFPVQYNKAIVGRNA 299 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K + PE G K S +GK +G+A + +++LG LS Sbjct 300 FAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKMEELGYKLSRNQ 359 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 ++ V R L D+ K V ED+ ++ D G+ + + S + +G A ++L Sbjct 360 IEDVFVRFKALADRKKDVYDEDIEALV-DEQLLHGQDQIKLMSLTVIAGTHGPQRATMKL 418 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP---KLIDYEVRIPPGGKTDALVET 470 + G+I E +EG+G DA N + + +P KL Y+V G TDA E Sbjct 419 DVDGQIRIEEAEGNGPVDAVFNCIKAL-------VPHDAKLELYQVHAVTEG-TDAQAEV 470 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + + E ++ PD VA+ A LN+I+ Q Sbjct 471 SVRLS-----HEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Dictyoglomus thermophilum H-6-12] Sequence ID: B5YEF4.1 Length: 503 Range 1: 2 to 497 Score:173 bits(438), Expect:1e-46, Method:Compositional matrix adjust., Identities:157/512(31%), Positives:241/512(47%), Gaps:22/512(4%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 T+L I D TLRDGEQT GV+ + EKL IAK L KLNVD +E S GE E V+ I Sbjct 2 TKLYIFDTTLRDGEQTPGVNLNKEEKLEIAK-QLAKLNVDIIEAGFPIASPGEFEAVKTI 60 Query 66 MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 E + + +D ++ + IK S + ++ S H+EK+L KT E Sbjct 61 AENVKGPVIAALARAIP-MDIDRAWEAIKYSESPRIHTFIATSDIHIEKKLKKTRDEVLE 119 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 ++YA + + ED R+ +++ + E + I +PDT+G P Sbjct 120 QAVSAVKYAKRYCSDVEFSAED---AVRSDFNFLVKIFEAVIDAGATVINIPDTVGYALP 176 Query 186 EETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E + L + +I H HND L+ ANSL AI G + + +INGLGERAG Sbjct 177 WEFGDLIRRLKENIKNIDKAIVSVHCHNDLGLATANSLSAIVNGAEQVECTINGLGERAG 236 Query 243 NTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 N +E +V I + + I I + S+LV +G I N+ IVGE+ F +G+ Sbjct 237 NAAMEEIVMAIKVRRLPFEVGIKTEEIYKTSKLVSNLTGIVIQPNKAIVGENAFAHESGI 296 Query 302 HADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLER 360 H G + I P+ G S LGK +GK + + +++LG L L++ ++ Sbjct 297 HQHGVIQDPSTYEIIDPKMIGIPESKIVLGKHSGKHAFEKRLQELGYSLPPEQLEEAFKK 356 Query 361 VIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIH 420 EL D+ K +T +D+ ++++ E + + SGIGI P A I + G+ Sbjct 357 FKELADKKKEITDKDIEALVSNQIKLVPEYYRLV-HLQVVSGIGIVPTATIIISEDGEEI 415 Query 421 KEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRIPPGGKTDALVETRITWNKSLD 479 K + G+G DA A+ K I IP L D+ ++ GG TDAL E + L Sbjct 416 KTVEIGNGPVDAVYKAIAK-----AIKIPHSLEDFSLKSVTGG-TDALGEAMV----KLS 465 Query 480 LEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 ++ + D A+ A + LNQ++ Sbjct 466 DKDGNIYVGRATSTDIVEASALAYLRALNQLV 497 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Parasynechococcus marenigrum WH 8102] Sequence ID: Q7U892.1 Length: 540 Range 1: 1 to 517 Score:173 bits(439), Expect:1e-46, Method:Compositional matrix adjust., Identities:154/537(29%), Positives:249/537(46%), Gaps:46/537(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASAGDFA 59 Query 61 TVQKIMEWAATEQLTERIEILGFV-----DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I + E I G D + + + + ++ S HLE + Sbjct 60 AVQRIAQQVGGENGPI---ICGLARASQRDIKACAEAVSPAPRRRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ + V ++ YA I ED R+ P+++ ++E I Sbjct 117 LRKSRADVLGIVPEMVSYARSLMDDIEFSCEDAG---RSDPEFLYEVIEAAIAAGATTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKY-PDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLH 231 +PDT+G +P E F + + I +Y P+I HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGYTTPSE-FGDLIAGINRYVPNIGEAVLSVHGHNDLGLAVANFLEAVKNGARQLE 232 Query 232 ASINGLGERAGNTPLEALVTTIHDK-----------SNSKTNINEI---AITEASRLVEV 277 +ING+GERAGN LE LV +H + +S T ++ + +T+ SRLV Sbjct 233 CTINGIGERAGNASLEELVMALHVRRRYFNPFFGRDQDSPTPLSAVRTEELTKTSRLVSN 292 Query 278 FSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKA 336 +G + N+ IVG + F +G+H DG K L I + G +LGKL+G++ Sbjct 293 LTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNRISLGKLSGRS 352 Query 337 SISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKS 396 ++ +++LG L+ L + R +L D+ + +T DL I+++ + E ++ Sbjct 353 AVRARLEELGYDLTREDLDEAFARFKDLADRKREITDRDLEAIVSE-QVQQPEARYQLQL 411 Query 397 CNIHSGIGIRPHAQIELEYQGKIHKEISE-GDGGYDAFMNALTKITNRLGISIP-KLIDY 454 + G ++P A + L + + +S G G DA AL ++ +P +LI++ Sbjct 412 VQVSCGTRLKPTATVALSEENGPDQTVSAVGTGPVDAVCRALNQLAG-----VPNELIEF 466 Query 455 EVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 V+ G DA+ E I + L T D VAA A LN+++ Sbjct 467 SVKSVTEG-IDAMGEVTIRLRRDGSLYSGHAADT-----DVVVAAAMAFINALNRLV 517 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Anoxybacillus flavithermus WK1] Sequence ID: B7GH19.1 Length: 514 Range 1: 3 to 500 Score:172 bits(437), Expect:1e-46, Method:Compositional matrix adjust., Identities:152/520(29%), Positives:249/520(47%), Gaps:41/520(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ+ GV+ + EKL IA+ L++L VD +E SKG+ + VQ I Sbjct 3 KINIFDTTLRDGEQSAGVNLNLHEKLEIAR-QLERLGVDIIEAGFPAASKGDFQAVQAIA 61 Query 67 EWAATEQLTERIEILGF---VDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 Q + G V + W +KD L++ S H++ +L TP+ Sbjct 62 ------QTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKLRMTPE 115 Query 122 EFFTDVSFVIEYAIKSGLKINVYLE--DWS--NGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + V+E A++S Y WS + R+ ++ ++VE + + I +P Sbjct 116 Q-------VVETAVESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIP 168 Query 178 DTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G ++P++ F + ++ I H H+D ++VANSL AI AG + +I Sbjct 169 DTVGYITPKQYGDIFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTI 228 Query 235 NGLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGN +E + ++ D ++T +N I S LV +G + AN+ IVG Sbjct 229 NGIGERAGNAAIEEVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVG 288 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLS 350 ++ F +G+H DG K I P+ G + S LGK +G+ + +++LG L+ Sbjct 289 KNAFAHESGIHQDGVLKEKTTYEIISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSLT 348 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 E + ++ R +L D+ K +T +DL +I D T + + S + G P A Sbjct 349 EEEVNRLFVRFKDLADKKKDITDDDLIALILDEKLDTYKNFYQLCSIQVQYGTNQIPTAV 408 Query 411 IEL-EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRIPPGGKTDALV 468 + L + +G +E + G G +A NAL K + +P L+DY + G+ DAL Sbjct 409 VVLKDGEGNDIQEAATGAGSVEALYNALEK-----ALQLPVTLLDYRIESVGSGR-DALA 462 Query 469 ETRITWNKSLDLEEDQTFKT-MGVHPDQTVAAVHATEKML 507 + + SLD +E T V A +HA +M Sbjct 463 QVYVKV--SLDRKEASGRGTAQDVLEASAKAYIHAVNRMF 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Neisseria meningitidis FAM18] Sequence ID: A1KTV6.1 Length: 517 Range 1: 6 to 442 Score:172 bits(437), Expect:1e-46, Method:Compositional matrix adjust., Identities:133/449(30%), Positives:214/449(47%), Gaps:27/449(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G + + EK+ +A+ L+KL VD +E A S G+ E V I Sbjct 6 RVIIFDTTLRDGEQSPGAAMTKEEKIRVAR-QLEKLGVDIIEAGFAAASPGDFEAVNAIA 64 Query 67 EW---AATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 + + L+ IE D + + + + K ++ S H+E +L PK+ Sbjct 65 KTITKSTVCSLSRAIE----RDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQ- 119 Query 124 FTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 VIE A+K+ Y +D + R+ D++ + + + I +PDT Sbjct 120 ------VIEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDT 173 Query 180 LGVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P +T + LI K P+ + + H HND L+VANSL A++ G + + ++NG Sbjct 174 VGYSIPYKTEEFFRELIVKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNG 233 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGN +E +V + HD +T I+ I +S+LV +G + N+ IVG + Sbjct 234 LGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGAN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SE 351 F+ +G+H DG K + E G +LGKL+G+ + + LG+ L SE Sbjct 294 AFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESE 353 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L R EL D+ + + EDL +++D G + S I + G P A I Sbjct 354 EALNAAFARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADI 413 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKI 440 +G+ + + G G DA A+ + Sbjct 414 VFSIKGEEKRASATGSGPVDAIFKAIESV 442 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodopseudomonas palustris BisB5] Sequence ID: Q138Z2.1 Length: 524 Range 1: 9 to 510 Score:173 bits(438), Expect:1e-46, Method:Compositional matrix adjust., Identities:146/525(28%), Positives:241/525(45%), Gaps:37/525(7%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + R+ I D TLRDGEQ G + + EKLN+A +L ++ VD +E S G+ E V + Sbjct 9 QDRVIIFDTTLRDGEQCPGATMTFEEKLNVAA-MLDEMGVDVIEAGYPFASDGDFEAVHE 67 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + + + + D ++ + IK + ++ S H++ +L Sbjct 68 IAKRSKNSVICG-LSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQ------- 119 Query 125 TDVSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 + + V E I S + + +D WS + R D++ +E K I LPDT+ Sbjct 120 MEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTV 179 Query 181 GVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G PEE F+ V + F H H+D ++VANS+ ++ G + + +ING+ Sbjct 180 GYAVPEEYREMFRKVRETVPNADKARFSVHCHDDLGMAVANSIAGVQGGARQIECTINGI 239 Query 238 GERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE +V + DK I +T AS+ V + + N+ IVG + Sbjct 240 GERAGNAALEEVVMAMRVRQDKVPYWNRIESKMLTHASKTVSAATSFPVQYNKAIVGRNA 299 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K + PE G K S +GK +G+A + +++LG LS Sbjct 300 FAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKMEELGYKLSRNQ 359 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 ++ V R L D+ K V ED+ ++ D G+ ++ +KS + +G A +++ Sbjct 360 IEDVFVRFKALADRKKDVYDEDIEALV-DEQLLHGQDLIRLKSLTVIAGTHGPQRATMKI 418 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP---KLIDYEVRIPPGGKTDALVET 470 + G++ E +EG+G DA N + + +P KL Y+V G TDA E Sbjct 419 DVDGQLRIEEAEGNGPVDAVFNCIKAL-------VPHDAKLELYQVHAVTEG-TDAQAEV 470 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + + E ++ PD VA+ A LN+I+ Q Sbjct 471 SVRLS-----HEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Halalkalibacterium halodurans C-125] Sequence ID: Q9K8E8.1 Length: 515 Range 1: 3 to 469 Score:172 bits(437), Expect:2e-46, Method:Compositional matrix adjust., Identities:135/481(28%), Positives:233/481(48%), Gaps:26/481(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ + D TLRDGEQ+ GV+ + EK+ IAK L++L VD +E S+G+ ++V+ I Sbjct 3 KISVFDTTLRDGEQSAGVNLNFEEKMEIAK-QLERLGVDIIEAGFPASSQGDFQSVKAIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 E +T + V + W +K + ++L S H+E +L TP++ Sbjct 62 ETVKGSSVTG---LARSVQKDIDAAWEALKSAEEPRIHLFIATSPIHMEHKLRMTPEQVI 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 ++YA + ED S R+ ++ ++E + + I LPDT+G + Sbjct 119 EKAVESVKYAASRFKHVQWSAEDAS---RSDFPFLAQIIEAVIQAGATVINLPDTVGYTT 175 Query 185 PEETFQGVDSLIQKYPDI---HFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 P+E + + Q P I H H+D ++VANSL AI+ G + +ING+GERA Sbjct 176 PQEIKRMFQYMKQNVPSIDKVSLSTHNHDDLGMAVANSLAAIQGGADQVECTINGIGERA 235 Query 242 GNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GN LE + ++ D ++T + I S LV +G + N+ +VG + F Sbjct 236 GNASLEEIAVALNIRKDHYETETGLILKEIKRTSSLVSKLTGMVVPNNKAVVGANAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K I PE G S LGK +G+ + V++LG ++ L + Sbjct 296 SGIHQDGVLKNKQTYEIITPEMVGVSSNSMVLGKHSGRHAFKTKVQELGFTGTDEQLNNI 355 Query 358 LERVIELGDQNKLVTPEDLPFIIAD--VSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 + +L D+ K +T +DL ++ + V G T +++ ++ G + A I ++ Sbjct 356 FKAFKDLADKKKEITEDDLFALMTEQTVGGETNH--YELQTLQVNYGSNLTNTATITMKL 413 Query 416 -QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 G++ +E + G G +A N L RL + KL+DY ++ GG+ DAL + + Sbjct 414 PSGEVAEEAATGSGSVEAIYNTL----ERLLDAPVKLLDYRIQSITGGR-DALADVYVQM 468 Query 475 N 475 + Sbjct 469 D 469 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodopseudomonas palustris CGA009] Sequence ID: Q6N858.1 Length: 524 Range 1: 9 to 510 Score:172 bits(437), Expect:2e-46, Method:Compositional matrix adjust., Identities:147/525(28%), Positives:239/525(45%), Gaps:37/525(7%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + R+ I D TLRDGEQ G + + EKLN+A+ +L + VD +E S G+ E V + Sbjct 9 QDRVIIFDTTLRDGEQCPGATMTFEEKLNVAR-MLDDMGVDVIEAGYPFASDGDFEAVHE 67 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + + + + D ++ + IK + ++ S H++ +L Sbjct 68 IAKRSKNSVICG-LSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQ------- 119 Query 125 TDVSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 + + V E I S + + +D WS + R D++ +E K I LPDT+ Sbjct 120 MEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTV 179 Query 181 GVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G PEE F+ V + F H HND ++VANS+ + G + + +ING+ Sbjct 180 GYAVPEEYRELFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGI 239 Query 238 GERAGNTPLEALVTTIHDKSNSKTNINEI---AITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE +V + + + N I +T AS+ V + + N+ IVG + Sbjct 240 GERAGNAALEEVVMAMRVRQDRLPYWNRIETTMLTHASKTVSAATSFPVQYNKAIVGRNA 299 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K + PE G K S +GK +G+A + +++LG LS Sbjct 300 FAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKMEELGYKLSRNQ 359 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 ++ V R L D+ K V ED+ ++ D G+ + + S + +G A ++L Sbjct 360 IEDVFVRFKALADRKKDVYDEDIEALV-DEQLLHGQDQIKLMSLTVIAGTHGPQRATMKL 418 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP---KLIDYEVRIPPGGKTDALVET 470 + G+I E +EG+G DA N + + +P KL Y+V G TDA E Sbjct 419 DVDGQIRIEEAEGNGPVDAVFNCIKAL-------VPHDAKLELYQVHAVTEG-TDAQAEV 470 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + + E ++ PD VA+ A LN+I+ Q Sbjct 471 SVRLS-----HEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Synechococcus sp. CC9902] Sequence ID: Q3AYY2.1 Length: 540 Range 1: 1 to 469 Score:173 bits(438), Expect:2e-46, Method:Compositional matrix adjust., Identities:140/482(29%), Positives:221/482(45%), Gaps:38/482(7%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M K R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ Sbjct 1 MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQ-QLARLGVDVIEAGFPFASAGDFA 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 VQ+I + + I G +K D + + ++ S HLE + Sbjct 60 AVQRIAQQVGGDNGPI---ICGLARASKADIKACADAVAPAPRGRIHTFIATSDIHLEHK 116 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ K+ V ++ YA + ED R+ P+++ ++E I Sbjct 117 LRKSRKDVLAIVPEMVSYARSLIEDVEFSCEDAG---RSDPEFLYEVIEAAIAAGATTIN 173 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + + Q P+I HGHND L+VAN L+A++ G + L Sbjct 174 IPDTVGYTTPSEFGGLIAGINQHVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLEC 233 Query 233 SINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEVF 278 +ING+GERAGN LE LV +H D T + +T+ SRLV Sbjct 234 TINGIGERAGNASLEELVMAMHVRRRYFNPFLGRKEDSPTPLTAVRTEELTKTSRLVSNL 293 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKAS 337 +G + N+ IVG + F +G+H DG K L I G +LGKL+G+++ Sbjct 294 TGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDARTVGLSDNRISLGKLSGRSA 353 Query 338 ISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC 397 + +++LG L+ L + R +L D+ + +T DL I+++ + E +K Sbjct 354 VRARLEELGYNLTREDLDEAFARFKDLADRKREITDRDLEAIVSE-QVQQPEARFQLKFV 412 Query 398 NIHSGIGIRPHAQIELEYQGKIHKEISE-GDGGYDAFMNALTKITNRLGISIPK-LIDYE 455 + G RP A + L + + +S G G DA AL + + +P LI++ Sbjct 413 QVSCGSTSRPTATVALMDEEGGERTVSAVGTGPVDAVCRALNCLAD-----VPNDLIEFS 467 Query 456 VR 457 V+ Sbjct 468 VK 469 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Neisseria meningitidis Z2491] Sequence ID: Q9JUK6.1 Length: 517 Range 1: 6 to 442 Score:172 bits(437), Expect:2e-46, Method:Compositional matrix adjust., Identities:133/449(30%), Positives:214/449(47%), Gaps:27/449(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G + + EK+ +A+ L+KL VD +E A S G+ E V I Sbjct 6 RVIIFDTTLRDGEQSPGAAMTKEEKIRVAR-QLEKLGVDIIEAGFAAASPGDFEAVNAIA 64 Query 67 EW---AATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 + + L+ IE D + + + + K ++ S H+E +L PK+ Sbjct 65 KTITKSTVCSLSRAIE----RDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQ- 119 Query 124 FTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 VIE A+K+ Y +D + R+ D++ + + + I +PDT Sbjct 120 ------VIEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDT 173 Query 180 LGVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P +T + LI K P+ + + H HND L+VANSL A++ G + + ++NG Sbjct 174 VGYSIPYKTEEFFRELIVKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNG 233 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGN +E +V + HD +T I+ I +S+LV +G + N+ IVG + Sbjct 234 LGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGAN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SE 351 F+ +G+H DG K + E G +LGKL+G+ + + LG+ L SE Sbjct 294 AFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESE 353 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L R EL D+ + + EDL +++D G + S I + G P A I Sbjct 354 EALNAAFARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADI 413 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKI 440 +G+ + + G G DA A+ + Sbjct 414 VFSIKGEEKRASATGSGPVDAIFKAIESV 442 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Listeria innocua Clip11262] Sequence ID: Q92A28.1 Length: 512 Range 1: 3 to 465 Score:172 bits(435), Expect:2e-46, Method:Compositional matrix adjust., Identities:138/477(29%), Positives:230/477(48%), Gaps:25/477(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 +++ D TLRDGEQT GV+F EK+ IA L+KL +D +E S G+ E V+ I Sbjct 3 KIQFFDTTLRDGEQTPGVNFDVKEKIQIA-LQLEKLGIDVIEAGFPISSPGDFECVKAIA 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ + L +E D ++ + +KD+ + +++ S H+E +L + E Sbjct 62 KAIKHCSVTGLARCVE----ADIDRAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + I YA + K +V + R+ ++ V+ I +PDT+G Sbjct 118 LASIKHHISYARQ---KFDVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYT 174 Query 184 SPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +P E FQ + I+++ DI F H H+D ++ AN+L AI G + + +ING+GER Sbjct 175 NPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGER 234 Query 241 AGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE + +H D ++TNI +S L+ SG + N+ ++G + + Sbjct 235 AGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAH 294 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I P G K S LGKL+GK + + ++++G LSE + Sbjct 295 ESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFNTRMEEMGYTLSEQEQKD 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 +R +L D K VT EDL +I S + + +K + G A + +E + Sbjct 355 AFKRFKQLADAKKDVTEEDLHALILGQSSESHD-AFELKHLQVQYVTGGVQGAIVRIEER 413 Query 417 -GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G + ++ + G G +A N + NRL +L DY ++ G+ DA E + Sbjct 414 DGALIEDAATGSGSIEAIYNTI----NRLMKQDIELTDYRIQAITAGQ-DAQAEVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter hominis ATCC BAA-381] Sequence ID: A7I0N8.1 Length: 504 Range 1: 3 to 504 Score:171 bits(434), Expect:3e-46, Method:Compositional matrix adjust., Identities:153/523(29%), Positives:239/523(45%), Gaps:33/523(6%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + ++ + D TLRDGEQ+ G S +T+EK+ +A L+KL VD +E A S G+ + +++ Sbjct 3 KNKIIVFDTTLRDGEQSPGASMNTAEKVELA-IQLEKLGVDVIEAGFAAASPGDFDAIER 61 Query 65 IMEWAA---TEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 I + L IE D + IK + K ++ S H+E +L +P Sbjct 62 ICGAVSKIRVCSLARAIE----KDIKAAGESIKSAKFKRIHTFIATSPIHMEYKLKLSPD 117 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + I+YA + ED R+ ++K +VE I LPDT+G Sbjct 118 DVIKKAINSIKYAKTFCDDVEFSCEDAG---RSEISFIKEIVEAAINAGATTINLPDTVG 174 Query 182 VLSPEETFQGVDSLIQKYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P E + L++ D H H+D +SVAN++ I+AG + + +INGLGER Sbjct 175 YRLPSEMSYMIGELVKFVGDRAVISSHCHDDLGMSVANTIACIKAGARQIECTINGLGER 234 Query 241 AGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 AGNT LE +V I +S+ T+IN I +SRLV +G N+ IVG++ F Sbjct 235 AGNTALEEVVMAIKTRSDVFAPLYTDINFKEIYHSSRLVATITGIEPQPNKAIVGKNAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K + E G K S LGK +G + + + LG LSE L Sbjct 295 HESGIHQDGVLKHKETYEIMRAEDIGLEKNSIVLGKHSGSHAFRDKLVSLGYNLSEDELA 354 Query 356 KVLERVIELGDQNKLVTPEDLPFIIAD--VSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 V E+ L D K + +DL ++ D V +++ + S + G A + L Sbjct 355 NVFEKFKILADAKKEIFDDDLRELMTDELVKIPCAFEIIALSSSECNKG---HASAALTL 411 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK-TDALVETRI 472 ++ +I K+ + G+G DA + +I+ G L DY+VR GK A V ++ Sbjct 412 KHNDEILKDSALGNGVVDAIFKTIDRISGIKG----NLKDYQVRAVSQGKDAQAKVTVKV 467 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + E T G+ D +A A LN + Q Sbjct 468 LF------ENSSTIIGHGLDTDTLMATAKAYIGALNSYISMKQ 504 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Listeria monocytogenes EGD-e] Sequence ID: Q8Y5R9.1 Length: 512 Range 1: 3 to 491 Score:172 bits(435), Expect:3e-46, Method:Compositional matrix adjust., Identities:144/507(28%), Positives:240/507(47%), Gaps:29/507(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 +++ D TLRDGEQT GV+F EK+ IA L+KL +D +E S G+ E V+ I Sbjct 3 KIQFFDTTLRDGEQTPGVNFDVKEKIQIA-LQLEKLGIDVIEAGFPISSPGDFECVKAIA 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ + L +E G +D + + +KD+ + +++ S H+E +L + E Sbjct 62 KAIKHCSVTGLARCVE--GDID--RAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + I YA + + ED + R+ ++ V+ I +PDT+G Sbjct 118 LASIKHHISYARQKFEVVQFSPEDAT---RSDRAFLIEAVQTAIDAGATVINIPDTVGYT 174 Query 184 SPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +P E FQ + I+++ DI F H H+D ++ AN+L AI G + + +ING+GER Sbjct 175 NPTEFGQLFQDLRREIKQFDDITFASHCHDDLGMATANALAAIENGARRVEGTINGIGER 234 Query 241 AGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE + +H D ++TNI +S L+ SG + N+ ++G + + Sbjct 235 AGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAH 294 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I P G K S LGKL+GK + + ++++G L+E + Sbjct 295 ESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFNTRMEEMGYTLTEQEQKD 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 +R +L D K VT EDL +I S + + +K + G A + +E + Sbjct 355 AFKRFKQLADAKKEVTEEDLHALILGQSSESADD-FELKHLQVQYVTGGVQGAIVRIEER 413 Query 417 -GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 G + ++ + G G +A N + NRL +L DY ++ G+ DA E + Sbjct 414 DGALVEDAATGSGSIEAIYNTI----NRLMKQDIELTDYRIQAITAGQ-DAQAEVHVVIK 468 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHA 502 E F +G+ D A+ A Sbjct 469 NDKGAE----FHGIGIDFDVLTASAKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Candidatus Blochmanniella pennsylvanica str. BPEN] Sequence ID: Q493R0.1 Length: 517 Range 1: 7 to 505 Score:172 bits(435), Expect:3e-46, Method:Compositional matrix adjust., Identities:149/522(29%), Positives:241/522(46%), Gaps:38/522(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA F L++L VD +E+ S G+ E+V I Sbjct 7 IFDTTLRDGEQALQASLNVKEKLQIA-FALERLGVDIMEVGFPISSPGDFESVHTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 ++I+ + +D D A+ L + +H H++ +L K Sbjct 62 -----AQKIKNSLVCALARCIDNDIDVAAEALKVAKNFRIHIFLPTSNVHIQSKLKKNFD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + I YA K I ED R + D + +VE + I +PDT+G Sbjct 117 QIIDMTVHAIRYARKYTDDIEFSCEDAG---RTNIDNLCRIVEIAIQSGASTINIPDTVG 173 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 +P + Q + SL + P I H H+D ++V NS+ AI+AG + + +ING+G Sbjct 174 YTTPYQFGQIITSLYNRVPIIDKAIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIG 233 Query 239 ERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 ERAGNT LE ++ I D N TN+ I AS++V I AN+ IVG + F Sbjct 234 ERAGNTALEEIIMAIKVREDLLNVHTNVRCQEIYRASQVVSQLCNIPIPANKAIVGSNAF 293 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVL 354 + +AG+H DG K + PE G K L +G+A++ ++K +G S+ + Sbjct 294 SHSAGIHQDGILKNRKNYEIMTPETIGLKDVKLNLTSRSGRAAVKHHMKTMGYQESDYDM 353 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 K+ + +EL D+ V DL + + + + +K ++ S HA ++L Sbjct 354 DKLYDVFLELADKKGQVFDYDLEALAFINNQQEQSEFFRLKCFHVDSSSSEVAHASVKLY 413 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 + S G+G DA ALT I+ +L I++ + Y++ G+ +AL + I Sbjct 414 CGNNTYTHSSSGNGPIDAIYEALTHIS-KLSINLER---YQLNAKGHGR-NALGQVDIVV 468 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + E + F +G+ D ++V A +LN I + Q+ Sbjct 469 SY-----EGRNFHGVGLDTDVIKSSVKAMIHVLNNIWRAKQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aliarcobacter butzleri RM4018] Sequence ID: A8ES07.1 Length: 517 Range 1: 3 to 503 Score:171 bits(434), Expect:4e-46, Method:Compositional matrix adjust., Identities:161/530(30%), Positives:248/530(46%), Gaps:52/530(9%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + ++ + D TLRDGEQ+ G S +T EK+ +A L+KL VD +E A S G+ + V + Sbjct 3 KNKIIVFDTTLRDGEQSPGCSMNTEEKIKVA-LQLEKLGVDVIEAGFAAASPGDFDAVSR 61 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDW-IKDSGAKVLNLLTKGSLH--------HLEKQ 115 I Q+ + I + VD IK +G V + K +H H++ + Sbjct 62 IA------QIIKNSSICSLA---RAVDNDIKQAGLAVQSA-AKSRIHTFIATSPIHMQYK 111 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L + E +EYA + LED R+ ++K +++ + + I Sbjct 112 LKMSGDEVIKRAIRAVEYAKTFVDDVEFSLEDAG---RSEIPFMKEVMDAVIGAGAKTIN 168 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIHF-EFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 LPDT+G P E V L D H HND L+ AN+L A+ G + + +I Sbjct 169 LPDTVGYRLPTELGAMVKELSAYAGDRAIISVHNHNDLGLATANTLAAVLNGARQIEVTI 228 Query 235 NGLGERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIV 290 NGLGERAGN+ LE V I + ++ T IN I SRLV +G N+ IV Sbjct 229 NGLGERAGNSALEEAVMAIKTRKDAFGDLYTTINTPEIYATSRLVATITGVEPQQNKAIV 288 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFG--RKRSYALGKLAGKASISENVKQLGM- 347 G++ F +G+H DG K + PE G + + LGK +G+A+ + + QLG Sbjct 289 GKNAFAHESGIHQDGVLKHQETYEIMKPEDVGVIKDSTLILGKHSGRAAFRDKIVQLGFD 348 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVS---GRTGEKV-LTIKSCNIHSGI 403 +S+ L ER L D K ++ ED+ +I D + +T + + L I C +G+ Sbjct 349 KVSDDELNAAFERFKVLADNKKEISDEDVRMLITDEALNHDKTYDLIGLQISDCT--NGV 406 Query 404 GIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK 463 P A + ++Y+ +I K+ + GDG DA + +IT G +L DY+V GK Sbjct 407 ---PTAAVAIKYKDEIIKDAAIGDGTMDAIFKTIDRITGFSG----ELKDYKVISVTEGK 459 Query 464 TDAL--VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 DAL V TR++++ E F G+ D +A A LN L Sbjct 460 -DALAKVTTRVSFD-----ETSPAFVGHGLSIDTMLATAKAYIGALNSYL 503 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia cenocepacia HI2424] Sequence ID: A0K933.1 Length: 514 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia orbicola MC0-3] Sequence ID: B1JVQ1.1 Length: 514 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia orbicola AU 1054] Sequence ID: Q1BV03.1 Length: 514 Range 1: 4 to 502 Score:171 bits(434), Expect:4e-46, Method:Compositional matrix adjust., Identities:149/519(29%), Positives:239/519(46%), Gaps:35/519(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L +++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAKHL-ERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 L + I N + D +K + + ++ S H+EK+L TP Sbjct 63 ------GLVKDSTICSLARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + F + +A K + ED G R+ D++ ++E + E I + DT+G Sbjct 117 QVFEQARLAVRFARKFTDNVEFSPED---GSRSDLDFLCRVLEAVIAEGATTINIADTVG 173 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGL 237 PE V +L ++ P+ F H HND ++VANSL ++ G + + +INGL Sbjct 174 YGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGNT LE +V + + + I+ I S+LV +G + N+ +VG + Sbjct 234 GERAGNTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANA 293 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEV 352 F +G+H DG K + E G LGKL+G+ + + +++LG+ L SE Sbjct 294 FAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEA 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQI 411 L R +L D+ + ED+ I+++ S E+ S + S G +P A++ Sbjct 354 ELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHFKFVSLSQRSETGEQPQAKV 413 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETR 471 +GK + G+G DA NA I +G S +L+ Y V G T A E Sbjct 414 VFAVEGKEVTGEARGNGPVDATFNA---IEGEVG-SGSELLLYSVNAITTG-TQAQGEVT 468 Query 472 ITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + +KS + +G PD A+ A LN++ Sbjct 469 VRLSKS-----GRIVNGVGTDPDIVAASAKAYISALNKL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Ruminiclostridium cellulolyticum H10] Sequence ID: B8I1T7.1 Length: 508 Range 1: 5 to 496 Score:171 bits(433), Expect:5e-46, Method:Compositional matrix adjust., Identities:146/514(28%), Positives:249/514(48%), Gaps:34/514(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI-- 65 ++I D TLRDGEQT GV+ + EKL IAK L+ +L VD +E A S G+ E++ + Sbjct 5 IKIFDTTLRDGEQTPGVNLNLQEKLEIAKQLV-RLGVDVIEGGFAIASPGDFESIMTLSR 63 Query 66 -MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 ++ L +E D ++ + ++ + + ++ S H++ +L T +E Sbjct 64 NLKGVTIASLCRSVE----KDIDRAWEAVQYAESPRIHTFIATSDIHMKYKLKMTEEEVL 119 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 +++ A + ED S R +++ +VE + K + +PDT+G + Sbjct 120 ERAVSMVKRAKGYCSNVEFSAEDAS---RTREEFLYRVVEAVIKAGATTVNIPDTVGYST 176 Query 185 PEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 P E + + ++ P+I H HND L+VANSL A+ G + +INGLGERA Sbjct 177 PLEFGRLIRNIRNNVPNIDKADISVHCHNDLGLAVANSLAAVENGAVQVECTINGLGERA 236 Query 242 GNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GN LE ++ I+ D + I+ I ASRLV +G + N+ IVG + F Sbjct 237 GNAALEEIIMGINTRKDYYDITHRIDTTQIYRASRLVSSLTGVNVQPNKAIVGANAFAHE 296 Query 299 AGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H G + PE G LGKL+G+ + + +K++G LS+ ++ Sbjct 297 SGIHQHGVLSEKTTYEIMTPESVGMGTNRMVLGKLSGRHAFEDRLKEMGYSLSDEEVKTA 356 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 + +L D+ K+VT +D+ ++ + ++ I S I+SG + + + + Sbjct 357 FAKFKDLADKKKVVTDKDIEALVDE--NIAVPEIFVIDSFQINSGNKMISTSTVSVRKDE 414 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRITWN 475 +I E + GDG DA NA+ + T G++ +L+ Y ++ GK DAL V +I+ N Sbjct 415 EIITEAATGDGPVDAAFNAVERAT---GVN-AELVHYRIKAVTEGK-DALGEVTVKISNN 469 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQ 509 S+ F GV D A+V A +N+ Sbjct 470 NSI-------FMGKGVSTDIIEASVKAYLNAINR 496 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Wolinella succinogenes DSM 1740] Sequence ID: Q7M9W4.1 Length: 519 Range 1: 6 to 508 Score:171 bits(433), Expect:6e-46, Method:Compositional matrix adjust., Identities:154/523(29%), Positives:244/523(46%), Gaps:34/523(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 ++I D TLRDGEQ+ G S +T EK+ IAK L++L VD +E A S G+ + + KI Sbjct 6 IKIFDTTLRDGEQSPGASMNTEEKIRIAK-QLERLGVDVIEAGFAAASPGDFDAISKIAS 64 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 A +E + D D + + K ++ S H+E +L TP E Sbjct 65 -AVSESTICSLARAVEKDIKAAADSLAPAKLKRIHTFIATSPIHMEYKLRMTPSEVIKRA 123 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 I YA + ED R+ ++K ++ + + + +PDT+G P E Sbjct 124 VEAIAYAKSFMEDVEFSCEDAG---RSDVGFLKEILAAVIEAGAGTLNIPDTVGYRLPHE 180 Query 188 TFQGVDSLIQKYPDIH-FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + L + + H HND L+VANSL I++G + + ++NGLGERAGN L Sbjct 181 MGAIIKELHEFVGNRAILSVHCHNDLGLAVANSLYCIQSGARQVECTVNGLGERAGNAAL 240 Query 247 EALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 E +V I + + T IN I +S+LV +G R N+ IVG++ F +G+H Sbjct 241 EEIVMAIKTRRDIFGGLDTRINTKEIYASSQLVANITGIRPQPNKAIVGKNAFAHESGIH 300 Query 303 ADGDKKGN-----LYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 DG K ++A+ I G + S LGK +G+ + + +K LG +S L Sbjct 301 QDGVLKHKETYEIMHASDI---GLGEQESIVLGKHSGRHAFKDKIKALGFEVSYEELNAA 357 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 +R L DQ K + ED+ I+A+ + KV + + RP+A I L+ +G Sbjct 358 FDRFKALCDQKKEIYDEDIRAILAEETSHI-PKVYELVGIQLSDCSMGRPYAAITLKKEG 416 Query 418 KIHKEISE---GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 +EI + G+G DA + +I+ G +L DY+V GK DAL + + Sbjct 417 S--EEIVDAAIGNGSVDALFKTIDRISQIKG----ELKDYKVEAVTQGK-DALAKVVV-- 467 Query 475 NKSLDLEEDQ-TFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 ++ EE++ G+H D +A A LN L ++ Sbjct 468 --KVEFEENKPAIIGHGLHIDTMLATAKAYVGALNSYLSMREL 508 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Acetivibrio thermocellus ATCC 27405] Sequence ID: A3DF94.1 Length: 511 Range 1: 3 to 439 Score:171 bits(432), Expect:6e-46, Method:Compositional matrix adjust., Identities:137/447(31%), Positives:218/447(48%), Gaps:23/447(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQT GV+ + EK++IAK L +L VD +E S G+ E VQ+I Sbjct 3 RIRIFDTTLRDGEQTPGVNLNIQEKVDIAK-QLARLGVDVIEPGFPLTSPGDFEAVQRIA 61 Query 67 EWAATEQLTERIEILGFV-----DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 E I GF D ++T IKD+ K ++ S ++ QLGKT K Sbjct 62 RE------VEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQLGKTEK 115 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + V + +A + ++ D S R +++ ++E I +PDT+G Sbjct 116 DVLEIVKSTVYHAKQYTDEVEYSPMDAS---RTRLEFLYEVIEAAIDNGATVINIPDTVG 172 Query 182 VLSP---EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 +P E Q + ++ H HND ++VANS+ A G + + +ING+G Sbjct 173 YATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTINGVG 232 Query 239 ERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 ERAGN LE +VT I + + +T I+ + + S++V + G I N+PIVG++VF Sbjct 233 ERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKNVF 292 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRKRSYA-LGKLAGKASISENVKQLGMVLSEVVL 354 T +G+H DG K I P GR S LGK +G+ ++ ++LG L E L Sbjct 293 THESGIHQDGVLKERSTYEVIDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDLDEERL 352 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL- 413 K+ +L D K VT DL +I + + + E+ ++ + SG P A++ + Sbjct 353 NKLFNDFKKLTDVKKNVTTADLESLIIESAAKAVEEAYVLEKIRVVSGNIETPSAKVVIK 412 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKI 440 + +G + + G+G DA A+ + Sbjct 413 DSKGNLLEAEQTGNGPVDAVFKAINSV 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Listeria monocytogenes serotype 4b str. CLIP 80459] Sequence ID: C1KWT1.1 Length: 512 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Listeria monocytogenes serotype 4b str. F2365] Sequence ID: Q71Y35.1 Length: 512 Range 1: 3 to 491 Score:171 bits(432), Expect:7e-46, Method:Compositional matrix adjust., Identities:143/507(28%), Positives:241/507(47%), Gaps:29/507(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 +++ D TLRDGEQT GV+F EK+ IA L+KL +D +E S G+ E V+ I Sbjct 3 KIQFFDTTLRDGEQTPGVNFDVKEKIQIA-LQLEKLGIDVIEAGFPISSPGDFECVKAIA 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ + L +E G +D + + +KD+ + +++ S H+E +L + E Sbjct 62 KAIKHCSVTGLARCVE--GDID--RAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + I YA + K +V + R+ ++ V+ I +PDT+G Sbjct 118 LASIKHHISYARQ---KFDVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYT 174 Query 184 SPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +P E FQ + I+++ DI F H H+D ++ AN+L AI G + + +ING+GER Sbjct 175 NPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGER 234 Query 241 AGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE + +H D ++TNI +S L+ SG + N+ ++G + + Sbjct 235 AGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAH 294 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I P G K S LGKL+GK + + ++++G L+E + Sbjct 295 ESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFNTRMEEMGYTLTEQEQKD 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 +R +L D K VT EDL +I S + + +K + G A + +E + Sbjct 355 AFKRFKQLADAKKEVTEEDLHALILGQSSESADD-FELKHLQVQYVTGGVQGAIVRIEER 413 Query 417 -GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 G + ++ + G G +A N + NRL +L DY ++ G+ DA E + Sbjct 414 DGALVEDAATGSGSIEAIYNTI----NRLMKQDIELTDYRIQAITAGQ-DAQAEVHVVIK 468 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHA 502 ++ F +G+ D A+ A Sbjct 469 N----DKGAVFHGIGIDFDVLTASAKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia multivorans ATCC 17616] Sequence ID: A9AJN4.1 Length: 514 Range 1: 4 to 439 Score:171 bits(432), Expect:7e-46, Method:Compositional matrix adjust., Identities:129/441(29%), Positives:211/441(47%), Gaps:15/441(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L +++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAKHL-ERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D + D +K + + ++ S H+EK+L TP++ + Sbjct 63 GLVKDSTVCS-LARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPEQVYEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A K + ED G R+ D++ ++E + E I + DT+G PE Sbjct 122 ARLAVRFARKFTDNVEFSPED---GSRSDMDFLCRVLEGVIAEGATTINITDTVGYGVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 V +L ++ P+ F H HND ++VANSL + G + + +INGLGERAG Sbjct 179 MYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVMIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + + + I+ I S+LV +G + N+ +VG + F + Sbjct 239 NTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQIELEYQ 416 R +L D+ + ED+ I++ S E+ S + HS G +PHA++ Sbjct 359 FMRFKDLADRKSEIFDEDIIAIVSQESALAQEQEHFKFVSLSQHSETGEQPHAKVVFSVD 418 Query 417 GKIHKEISEGDGGYDAFMNAL 437 GK + G+G DA +NA+ Sbjct 419 GKEVTGEARGNGPVDATLNAI 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica)] Sequence ID: A1AWA1.1 Length: 511 Range 1: 4 to 500 Score:171 bits(432), Expect:7e-46, Method:Compositional matrix adjust., Identities:158/528(30%), Positives:241/528(45%), Gaps:54/528(10%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK +L+K+ VD +E A S G+ E VQ + Sbjct 4 KLIIFDTTLRDGEQSPGASMTRDEKVRIAK-VLEKMQVDVIEAGFAIASVGDFEAVQTVA 62 Query 67 E-------WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKT 119 + + L + I+ G + +K + A ++ S H++ +L T Sbjct 63 NVVQDSIICSLSRALDKDIDCAG--------EALKGANASRIHTFIATSDIHMKMKLQMT 114 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIF 175 P + V+E A+++ + Y D + R+ D++ ++E I Sbjct 115 PDQ-------VVEQAVRAVKRAKRYTNDVEFSPEDAGRSDEDFLCRIIEATINAGATTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P + + SLI + P+ F H HND L+VANSL A+ G + + Sbjct 168 IPDTVGYNIPHQFGVTIKSLIGRVPNSDKAIFSAHCHNDLGLAVANSLSAVLNGARQVEC 227 Query 233 SINGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPI 289 +INGLGERAGNT LE LV + D + T+IN I ASRLV +G + N+ I Sbjct 228 TINGLGERAGNTSLEELVMAVRTRQDIFDCDTDINATHILSASRLVSSVTGFIVQPNKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMV 348 VG + F AG+H DG K + E G LGK +G+ + + +LG+ Sbjct 288 VGANAFAHEAGIHQDGVIKYRETYEIMRAEDVGWNANQLVLGKHSGRNAFKVRLAELGVE 347 Query 349 L-SEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE--KVLTIKSCNIHSGIGI 405 +E L R EL D+ + EDL ++++ E K++++K C + G Sbjct 348 FNNEEGLNDAFRRFKELADKKHEIFDEDLQALVSETQTEAYEAIKLVSLKVC---TETGE 404 Query 406 RPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTD 465 + A + L K + G DA A++ +T GI I L Y V G TD Sbjct 405 KNTATVVLSIDDKEQTATANTSGAVDATFIAISSLT---GIKI-NLQLYSVSNVTQG-TD 459 Query 466 AL--VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 AL V R+ N + GV D A+ A LN++L Sbjct 460 ALGEVNVRLECNGRI-------VNGQGVDTDIITASAKAYVHGLNKVL 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Afipia carboxidovorans OM5] Sequence ID: B6JB87.1 Length: 519 Range 1: 11 to 510 Score:171 bits(432), Expect:9e-46, Method:Compositional matrix adjust., Identities:145/519(28%), Positives:241/519(46%), Gaps:29/519(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKL +A+ +L + VD +E S G+ E V +I Sbjct 11 RVVIFDTTLRDGEQCPGATMTHEEKLEVAE-MLDTMGVDIIEAGFPIASVGDFEAVAEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A + + D + + ++ + ++ S HL Q+ K+ ++ Sbjct 70 KRANNAVIAGLARAIP-ADIVRAGEAVRHAKRGRIHTFVSTSPIHLAHQMRKSEEDVLGI 128 Query 127 VSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 ++ + A L +V +WS + R DY+ VE I LPDT+G Sbjct 129 ITATVAQA--RNLVDDV---EWSAMDSTRTPIDYLCRCVETAIAAGATTINLPDTVGYAV 183 Query 185 PEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 PEE + + ++ P+ F H H+D L+VANSL + G + + +ING+GERA Sbjct 184 PEEYRRMFKVIRERVPNADKAVFSVHCHDDLGLAVANSLAGVEGGARQIECTINGIGERA 243 Query 242 GNTPLEALVTTIHDKSNSK---TNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GN LE +V I + + N+ +T AS++V + + N+ IVG + F Sbjct 244 GNAALEEVVMAIKTRGDVMPYWCNVESTTLTRASKVVSAATSFPVQYNKAIVGRNAFAHE 303 Query 299 AGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K + PE G K+ S +GK +G+ + +++LG L++ LQ Sbjct 304 SGIHQDGVLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLRELGYELADNQLQDA 363 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 R L D+ K + ED+ ++ +T ++ L + S + +G A +++E G Sbjct 364 FVRFKALADRKKDIYDEDIEALVDQELAQTHDR-LRLVSLTVIAGTHGPQRATMKVEVDG 422 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 K+ + +EG+G DA NA+ + KL Y+V G TDA E S Sbjct 423 KVRIDEAEGNGPVDAVFNAVKTLVPHEA----KLELYQVHAVTAG-TDAQAEV------S 471 Query 478 LDLEED-QTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 + L +D ++ PD VA+ A LN+I+ Q Sbjct 472 VRLSQDGRSVTARSSDPDTLVASAKAYLSALNKIISRQQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus pumilus SAFR-032] Sequence ID: A8FFW5.1 Length: 517 Range 1: 3 to 468 Score:170 bits(431), Expect:1e-45, Method:Compositional matrix adjust., Identities:148/484(31%), Positives:232/484(47%), Gaps:35/484(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ D TLRDGEQ+ GV+ + EKL IAK L++L V+ +E S+G+ VQ+I Sbjct 3 KINFFDTTLRDGEQSPGVNLNAQEKLIIAK-QLERLGVNIIEAGFPASSRGDFLGVQEI- 60 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 A T + + V G+ W +KD L++ S HL+ +L KT +E Sbjct 61 --ARTIKNCSVAGLARCVKGDIDAAWEALKDGVEPRLHVFIATSDIHLKHKLKKTREEVV 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 +++YA K + WS + R D++ +VE + I LPDT+G Sbjct 119 EQAVAMVKYA-----KERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVINLPDTVGY 173 Query 183 LSPEETFQGVDSLIQKYPDI---HFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 L+P+E + + P+I + H H+D ++VANSL AI G + ++NG+GE Sbjct 174 LAPKEYGNIFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIETAVNGIGE 233 Query 240 RAGNTPLEALVTTIHDKSN-----SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 RAGN LE + +H + + S +NEI T S +V +SG + N+ +VG + Sbjct 234 RAGNAALEEIAVALHIRKDFYQVESTIQLNEIKRT--SDVVSKYSGMIVPRNKAVVGNNA 291 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K I PE G LGK +G+ + + +K LG L+E Sbjct 292 FAHESGIHQDGFLKEKTTYEIISPELVGVTTDVLVLGKHSGRHAFKDRMKTLGFKLTEEE 351 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 + K E L ++ K +T +DL II + + +S +H G P A + L Sbjct 352 INKFFETFKNLTEKKKEITDDDLISIILEEKVADRKIGYEFESLQVHYGTEQMPTATVSL 411 Query 414 EYQ--GKIHKEISEGDGGYDAFMNALTK-ITNRLGISIPKLIDYEVRIPPGGK-TDALVE 469 + Q ++ +E + G G +A N L + + R+ L+DY RI GK DAL E Sbjct 412 KNQETQEVIQEAATGAGSVEAVYNTLERCMEERI-----HLLDY--RIQSNGKGRDALAE 464 Query 470 TRIT 473 +T Sbjct 465 VYVT 468 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Trichodesmium erythraeum IMS101] Sequence ID: Q112U2.1 Length: 541 Range 1: 1 to 521 Score:171 bits(432), Expect:1e-45, Method:Compositional matrix adjust., Identities:152/542(28%), Positives:238/542(43%), Gaps:48/542(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M + R+ I D TLRDGEQ+ G + + EKL IA+ L L VD +E S G+ E Sbjct 1 MITSQDRVIIFDTTLRDGEQSPGATLNIDEKLTIAR-QLSLLGVDVIEAGFPYASIGDFE 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HL 112 VQKI E E I G +T ++ K L K +H HL Sbjct 60 AVQKIAEIVGVEGGPT---ICGLA---RTTRADIEAAGKALKPAAKARIHTFIATSDIHL 113 Query 113 EKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIE 172 +L KT E S ++ YA + ED R+ P+++ ++E Sbjct 114 AYKLKKTRAEVLEIASEMVAYAKTFVDDVEFSPEDAG---RSDPEFLYQVLEKAIAAGAT 170 Query 173 RIFLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKG 229 + +PDT+G +P E + + + P+I HGHND L+VAN L+A++ G + Sbjct 171 TVNIPDTVGYTTPAEFGGLIRGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQ 230 Query 230 LHASINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLV 275 L +ING+GERAGN LE LV H + TNIN I + SRLV Sbjct 231 LECTINGIGERAGNAALEELVMAFHVRRQYFNPFFGRPPESETPLTNINTRHIYKTSRLV 290 Query 276 EVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAG 334 +G + N+ IVG + F +G+H DG K L + + G LGKL+G Sbjct 291 SSLTGMFVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQSIGLTDNQIVLGKLSG 350 Query 335 KASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTI 394 + + +++LG LS+ + K + +L D+ K +T DL I+ + + ++ + Sbjct 351 RHAFQSRLQELGFKLSDEEINKAFIKFKDLADKKKEITDWDLESIV-NAEIQQPPELFRL 409 Query 395 KSCNIHSGIGIRPHAQIELEY-QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLID 453 + + G RP A + + G+ + + G G DA A+ ++ N L++ Sbjct 410 ELVQVSCGDRSRPTATVIIRTPNGEELTDAAIGTGPVDAVYKAINRVVNVEN----DLVE 465 Query 454 YEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQP 513 + V+ G DA+ E I E + + + D VA+ A LN++ Sbjct 466 FSVQSVTAG-IDAIGEVTIRVR-----HEGRVYSGHAANTDIIVASAEAYLSALNRLYAV 519 Query 514 WQ 515 Q Sbjct 520 LQ 521 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia vietnamiensis G4] Sequence ID: A4JGE0.1 Length: 514 Range 1: 4 to 474 Score:170 bits(431), Expect:1e-45, Method:Compositional matrix adjust., Identities:139/480(29%), Positives:227/480(47%), Gaps:20/480(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L +++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAKHL-ERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D + D +K + + ++ S H+EK+L TP + F Sbjct 63 GLVKDSTICS-LARANDKDIQRAADALKPASSARIHTFIATSPLHMEKKLRMTPDQVFEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A K + ED G R+ D++ ++E + E I + DT+G PE Sbjct 122 ARLAVRFARKFTDNVEFSPED---GSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 V +L ++ P+ F H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + + + I+ I S+LV +G + N+ +VG + F + Sbjct 239 NTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQIELEYQ 416 R +L D+ + ED+ I+++ S E+ + S + HS G +P A++ + Sbjct 359 FMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHVKFVSLSQHSETGEQPQAKVVFAVE 418 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTDALVETRITWN 475 G + G+G DA NA I +G S +L+ Y V I G + V R++ N Sbjct 419 GSEVTGEARGNGPVDATFNA---IEGEVG-SGSELLLYSVNAITTGTQAQGEVTVRLSKN 474 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130] Sequence ID: Q72RL9.2 Length: 501 >RecName: Full=2-isopropylmalate synthase 1; AltName: Full=Alpha-IPM synthase 1; AltName: Full=Alpha-isopropylmalate synthase 1 [Leptospira interrogans serovar Lai str. 56601] Sequence ID: Q8F445.2 Length: 501 Range 1: 7 to 442 Score:169 bits(429), Expect:1e-45, Method:Compositional matrix adjust., Identities:125/453(28%), Positives:217/453(47%), Gaps:36/453(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ G + + +EKL IA L + VD +E S + + V++I Sbjct 7 VRIFDTTLRDGEQCPGAAMTENEKLEIAS-QLATMKVDIIEAGFPVSSPVQFQAVERI-- 63 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKT 119 A E I L + + ++ +K L K +H H++ +LGK Sbjct 64 --ARETEGPMIAALA-----RAMKADIEAASKALQPAKKRRIHTFIASSPIHMKYKLGKE 116 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIF 175 PKE V++ A+++ +++D + R+ P++++ L E + I Sbjct 117 PKE-------VLKMAVEAVTLCRQFVDDVEFSPEDATRSEPEFLRELCEAVIAAGATTIN 169 Query 176 LPDTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E F+ + S ++ I F H HND L+ ANSL A++ G + + Sbjct 170 IPDTVGYTTPAEYGGLFKFLLSNVRGAEKIIFSAHCHNDLGLATANSLAAVQNGARQIEC 229 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGNT +E +V + + ++ +T I I AS LV+ +G + N+ I Sbjct 230 TINGIGERAGNTAMEEVVMAMRTRKDTFGIQTQIKTEEIARASYLVKTITGMLVQPNKAI 289 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMV 348 VG + F +G+H DG K + PE G LG+ +G+A + + +LG Sbjct 290 VGANAFAHESGIHQDGVIKHRETYEIMKPETVGLSSNRMVLGRHSGRAGFKDRIVKLGFS 349 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPH 408 L+ +R +E+ D+ K + ED+ + ++ + ++ ++ + +G P Sbjct 350 PQVEELEAAYQRFLEIADRKKEIYDEDIRALFSEEARKSTGDRFQLEGFTVSTGTKSTPT 409 Query 409 AQIELEYQGKIHKEISEGDGGYDAFMNALTKIT 441 A + + G + +E + GDG DA A+ K T Sbjct 410 AGVRILIDGHVREESATGDGPVDAIYKAIQKTT 442 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Prochlorococcus marinus str. MIT 9515] Sequence ID: A2BX52.1 Length: 546 Range 1: 1 to 484 Score:170 bits(431), Expect:2e-45, Method:Compositional matrix adjust., Identities:147/495(30%), Positives:232/495(46%), Gaps:34/495(6%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M+K R+ I D TLRDGEQ+ G S + EKL IA L +L VD +E S G+ + Sbjct 1 MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAH-QLARLGVDVIEAGFPFASPGDFK 59 Query 61 TVQKIMEWAATEQ--LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGK 118 V KI E E + + D + I + K ++ S HL+ +L K Sbjct 60 AVNKISEVVGGENGPIICGLARASTSDIKACYEAIIPAPKKRIHTFIATSDIHLKHKLRK 119 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + K+ + V ++ YA I ED S R+ P+++ +++ I +PD Sbjct 120 SRKDVLSIVPEMVSYAKSLVDDIEFSCEDAS---RSDPEFLYEVIQLAITSGATTINIPD 176 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +P E + + + + P+I HGHND L+VAN L+A + G + L +IN Sbjct 177 TVGFTTPSEFGKLIFDINKNVPNIDEAVISVHGHNDLGLAVANFLEAAKNGARQLECTIN 236 Query 236 GLGERAGNTPLEALVTTIHDK-----------SNSKTNINEI---AITEASRLVEVFSGK 281 G+GERAGN LE LV +H + S+S T + I IT+ SRLV +G Sbjct 237 GIGERAGNASLEELVMALHVRKSFFNSFFGRSSDSPTPLTAIRTEEITKTSRLVSNLTGM 296 Query 282 RISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISE 340 + N+ IVG + F +G+H DG K L I + G +LGKL+G++++ Sbjct 297 NVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLNDNKISLGKLSGRSAVRA 356 Query 341 NVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIH 400 ++++G LS L R +L D+ + +T DL I+++ + E + + Sbjct 357 RLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPESRFQLSHVQVS 415 Query 401 SGIGIRPHAQIELEYQGKIHKE---ISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR 457 G +P A + + + H E ++ G G DA A+ N L +LI++ V+ Sbjct 416 CGSTSKPTATVTI-LNTETHTEDTSVAIGTGPVDAVCEAI----NELAKVPNELIEFSVK 470 Query 458 IPPGGKTDALVETRI 472 G DAL E I Sbjct 471 SVTEG-IDALGEVTI 484 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Neisseria gonorrhoeae FA 1090] Sequence ID: Q5F8D4.2 Length: 597 Range 1: 86 to 522 Score:171 bits(433), Expect:2e-45, Method:Compositional matrix adjust., Identities:132/449(29%), Positives:212/449(47%), Gaps:27/449(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G + + EK+ +A+ L+KL D +E A S G+ E V I Sbjct 86 RVIIFDTTLRDGEQSPGAAMTKEEKIRVAR-QLEKLGADIIEAGFAAASPGDFEAVNAIA 144 Query 67 EW---AATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 + + L+ IE D + + + K ++ S H+E +L PK+ Sbjct 145 KTITKSTVCSLSRAIE----RDIRQAGKAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQ- 199 Query 124 FTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 VIE A+K+ Y +D + R+ D++ + + + I +PDT Sbjct 200 ------VIEAAVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIPDT 253 Query 180 LGVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P +T + LI K P+ + + H HND L+VANSL A++ G + + ++NG Sbjct 254 VGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNG 313 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGN +E +V + HD +T I+ I +S+LV +G + N+ IVG + Sbjct 314 LGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGAN 373 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SE 351 F+ +G+H DG K + E G +LGKL+G+ + + LG+ L SE Sbjct 374 AFSHESGIHQDGVLKHRETYEIMSAESVGWSANRLSLGKLSGRNAFKTKLADLGIELESE 433 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L R EL D+ + + EDL +++D G + S I + G P A I Sbjct 434 EALNAAFARFKELADKKREIFDEDLHALVSDEMGNMNAESYKFISQKISTETGEEPRADI 493 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKI 440 +G+ + + G G DA A+ + Sbjct 494 VFGIKGEEKRASATGSGPVDAIFKAIESV 522 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Listeria monocytogenes HCC23] Sequence ID: B8DBU4.1 Length: 512 Range 1: 3 to 491 Score:169 bits(428), Expect:2e-45, Method:Compositional matrix adjust., Identities:144/507(28%), Positives:239/507(47%), Gaps:29/507(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 +++ D TLRDGEQT GV+F EK+ IA L+KL +D +E S G+ E V+ I Sbjct 3 KIQFFDTTLRDGEQTPGVNFDVKEKIQIA-LQLEKLGIDVIEAGFPISSPGDFECVKAIA 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ + L +E G +D + + +KD+ + +++ S H+E +L + E Sbjct 62 KAIKHCSVTGLARCVE--GDID--RAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + I YA + + ED + R+ ++ V+ I +PDT+G Sbjct 118 LASIKHHISYARQKFEVVQFSPEDAT---RSDRAFLIEAVQTAIDAGATVINIPDTVGYT 174 Query 184 SPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +P E FQ + I+++ DI F H H+D ++ AN+L AI G + + +ING+GER Sbjct 175 NPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGER 234 Query 241 AGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE + +H D ++TNI +S L+ SG + N+ ++G + + Sbjct 235 AGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAH 294 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I P G K S LGKL+GK + ++++G LSE L+ Sbjct 295 ESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFQTRMEEMGYNLSEQELKD 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EY 415 +R +L D K VT +DL +I S + + +K + G A + + E Sbjct 355 AFKRFKQLADAKKEVTEDDLHALILGQSSESADD-FELKHLQVQYVTGGVQGAIVRIAER 413 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 G + ++ + G G +A N + NRL +L +Y ++ G+ DA E + Sbjct 414 DGTLIEDAATGSGSIEAIYNTI----NRLMKQNIELTNYHIQAITAGQ-DAQAEVHVVIK 468 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHA 502 E F +G+ D A+ A Sbjct 469 DKSGAE----FHGIGIDFDVLTASAKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia cenocepacia J2315] Sequence ID: B4E5N2.1 Length: 514 Range 1: 4 to 502 Score:169 bits(427), Expect:3e-45, Method:Compositional matrix adjust., Identities:147/514(29%), Positives:238/514(46%), Gaps:25/514(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L +++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAKNL-ERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D + D +K + + ++ S H+EK+L TP + F Sbjct 63 GLVKDSTICS-LARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A K + ED G R+ D++ ++E + E I + DT+G PE Sbjct 122 ARLAVRFARKFTDNVEFSPED---GSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 V +L ++ P+ F H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + + + I+ I S+LV +G + N+ +VG + F + Sbjct 239 NTSLEEIVMAVKTRKDYFGLDVGIDTSQIVPTSKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQIELEYQ 416 R +L D+ + ED+ I+++ S E+ S + S G +P A++ + Sbjct 359 FMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHFKFVSLSQRSETGEQPQAKVVFAVE 418 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNK 476 GK + G+G DA NA I +G S +L+ Y V G T A E + +K Sbjct 419 GKEVTGEARGNGPVDATFNA---IEGEVG-SGSELLLYSVNAITTG-TQAQGEVTVRLSK 473 Query 477 SLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 S + +G PD A+ A LN++ Sbjct 474 S-----GRIVNGVGTDPDIVAASAKAYISALNKL 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Lactococcus cremoris subsp. cremoris SK11] Sequence ID: Q02YX5.1 Length: 513 Range 1: 3 to 479 Score:169 bits(427), Expect:3e-45, Method:Compositional matrix adjust., Identities:145/497(29%), Positives:232/497(46%), Gaps:29/497(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++E D +LRDGEQT GV FS +EK+ IAK L+K + +E S E V++I Sbjct 3 KIEFFDTSLRDGEQTPGVIFSIAEKVTIAK-QLEKWGISVIEAGFPAASPDSFEAVKQIS 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A E + D +K V+ ++++ +++ S H++ + +P E Sbjct 62 K-ALKETAVTALARCVITDIDKAVEAVREAQHPQIHVFIATSPIHMKYKFKISPDEVLKT 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + +A + + ED + R P+++ V+ I +PDT+G +PE Sbjct 121 IDKCVRHAHEQVEVVEFSPEDAT---RTEPEFLLKAVQTAVDAGATYINIPDTVGYTTPE 177 Query 187 E---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E F+ + I+ +I F H H+D ++VANSL AI+AG + ++NG+GERAGN Sbjct 178 EYGKIFKMLIDNIKADREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGN 237 Query 244 TPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 +E + +H D +K+ + + L+ FSG I N+ +VG + F +G Sbjct 238 AAIEEIAVALHIRKDYYQAKSPLVLAETMATAELISQFSGIAIPKNKAVVGANAFAHESG 297 Query 301 VHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K I PE G K S LGKL+G+ + +E + +L + L + E Sbjct 298 IHQDGVLKNAETYEIISPELVGIKHNSLPLGKLSGRHAFTEKLTELNISYDAKELPNLFE 357 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPH-AQIELEYQ-G 417 R L D+ K +T D+ + TGE V + I + + I H A +EL+ Q Sbjct 358 RFKRLADKKKEITDADIHALF------TGETVKNLAGF-ILNNVQIDGHKALVELKNQDA 410 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 +I+ EG G DA A+ K+ N KLI Y V G DA T ++ Sbjct 411 EIYVSQGEGSGSVDAIFQAIDKVFNYQ----LKLISYSVDAVTNG-IDAQATTVVSVE-- 463 Query 478 LDLEEDQTFKTMGVHPD 494 +L F GV D Sbjct 464 -NLATGTIFNAKGVDYD 479 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodopseudomonas palustris BisB18] Sequence ID: Q212A9.1 Length: 521 Range 1: 11 to 506 Score:169 bits(428), Expect:4e-45, Method:Compositional matrix adjust., Identities:139/514(27%), Positives:237/514(46%), Gaps:27/514(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKL +A LL + VD +E S G+ V +I Sbjct 11 RVIIFDTTLRDGEQCPGATMTFEEKLEVAS-LLDAMGVDVIEAGFPIASDGDFAAVHEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A + + G D ++ + I+ + ++ S H++ +L ++ + Sbjct 70 KRAKNAVICG-LSRAGAKDIDRCAEAIRPAKQGRIHTFLSTSPVHMKYKLQMDAEQVYQL 128 Query 127 VSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 V + A + +WS +G R D++ VE K I +PDT+G Sbjct 129 VISAVTRARNHTDNV-----EWSSEDGTRTEFDFLCKCVEAAIKAGATTINIPDTVGYSV 183 Query 185 PEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 PEE F + + P+ F H H+D ++VANSL IR G + + ++NG+GERA Sbjct 184 PEEYFDLFKRVRENVPNSDKAIFSVHCHDDLGMAVANSLAGIRGGARQIECTVNGIGERA 243 Query 242 GNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GNT LE +V + +DK I+ +T AS++V + + N+ IVG + F Sbjct 244 GNTALEEVVMAMRVRNDKLPFWNKIDTTMLTRASKVVSAATSFPVQYNKAIVGRNAFAHE 303 Query 299 AGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K + PE G K+ S +GK +G+ + ++++G L + L+ Sbjct 304 SGIHQDGMLKNAETYEIMRPESVGVKQTSLVMGKHSGRHAFVHKLEEMGYKLGQNQLEDA 363 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 R L D+ K + ED+ ++ ++ +++ + S + +G A ++L+ +G Sbjct 364 FVRFKALADRKKEIYDEDIEALVDQEIAQSHDRI-KLLSLTVIAGTHGPQRATMKLDVEG 422 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 + E +EG+G DA N + + + KL Y+V G TDA E + Sbjct 423 QTRIEEAEGNGPVDAVFNCIKALVPH----VAKLELYQVHAVTQG-TDAQAEVSVRL--- 474 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 E ++ PD VA+ A LN+I+ Sbjct 475 --AHEGRSMTARAADPDTLVASAKAYLSALNKIV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Verminephrobacter eiseniae EF01-2] Sequence ID: A1WNY5.1 Length: 512 Range 1: 4 to 501 Score:168 bits(426), Expect:5e-45, Method:Compositional matrix adjust., Identities:146/519(28%), Positives:240/519(46%), Gaps:36/519(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EKL IA+ L++L VD +E A S G+ + V+ I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKDEKLRIAR-QLERLKVDVIEAGFAASSNGDFDAVRAI- 61 Query 67 EWAATEQLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 A+T I N + ++ + +++ S H+EK+L TP Sbjct 62 --AST---IREATICSLARANDRDIARAAQALEGAANARIHIFIATSALHMEKKLRMTPG 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 + + +A I ED G+R+ PD++ ++E E I +PDT+G Sbjct 117 QVLEQSLQSVRFARNLVADIEFSPED---GYRSDPDFLCRVIEAAIAEGATTINVPDTVG 173 Query 182 VLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGL 237 PE + L ++ P+ + H HND ++VANSL ++ G + + +INGL Sbjct 174 YAIPELYGNFIKMLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKMGGARQVECTINGL 233 Query 238 GERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE +V + + + I I ASR+V +G + N+ IVG + Sbjct 234 GERAGNCSLEEVVMAVKTRRDYFGLDLGIATQHILAASRMVSQTTGFAVQLNKAIVGANA 293 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEV 352 F +G+H DG K + + G LGKL+G+++ + +++LG+ L SE Sbjct 294 FAHASGIHQDGVLKARDTYEIMRAQDVGWSANKMVLGKLSGRSAFKQRLQELGVSLDSEA 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 + R EL D+ + ED+ +++D S + S S G +PHA+I Sbjct 354 EINLAFARFKELADRKSEIFDEDILALVSDESVSGDNEQYGFVSLFQQSETGKQPHARIV 413 Query 413 LEYQGK-IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETR 471 G+ +H E ++G+G DA + A+ + S +++ Y V G T++ E Sbjct 414 FTVNGQNVHAE-AQGNGPVDASLKAIEAHVH----SGAEMVLYSVN-AISGSTESQGEVT 467 Query 472 ITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + S + +G PD VA+ A LN++ Sbjct 468 VRLQNS-----GRIVNGVGADPDIVVASAKAYFSALNKL 501 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitrosococcus oceani ATCC 19707] Sequence ID: Q3J877.1 Length: 511 Range 1: 4 to 503 Score:168 bits(426), Expect:5e-45, Method:Compositional matrix adjust., Identities:141/519(27%), Positives:241/519(46%), Gaps:31/519(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L + D TLRDGEQ+ G S + EK+ IAK L+++ VD +E S+G+ E VQ + Sbjct 4 KLIVFDTTLRDGEQSPGASMTREEKVRIAK-ALERMRVDVIEAGFPVASQGDFEAVQAVA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + LG D ++ + + ++ + ++ S H++++L P + Sbjct 63 RSVRESTVCGLARALG-ADIDRAGEALAEAESARIHTFIATSPIHMKRKLRMEPDQ---- 117 Query 127 VSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V+E+A+K+ + Y +D + R+ +++ ++E + + +PDT+G Sbjct 118 ---VLEHAVKAVKRAREYTDDVEFSPEDAGRSEIEFLCRILEAVIAAGARTVNIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 PE+ Q + +L ++ + F H HND ++VANSL A+ +G + + +INGLGE Sbjct 175 NLPEQFAQLIRTLRERVSNSDKAIFSVHCHNDLGMAVANSLAAVMSGARQVECTINGLGE 234 Query 240 RAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE +V + + +S TN++ I SRLV +G + N+ IVG + F Sbjct 235 RAGNAALEEVVMAVRTRQDSFPCDTNVDISQIVPTSRLVSGITGFSVQPNKAIVGANAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVL 354 +G+H DG K + E G LGK +G+ + +++LG+ L +E L Sbjct 295 HASGIHQDGVLKERQTYEIMSAEDVGWHANQMILGKHSGRNAFRARLRELGIELETEEEL 354 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 +R EL D+ ++ EDL ++ D + + + + S G A + L Sbjct 355 NAAFQRFKELADKKHVIYDEDLQALVTDANLAAENERFKLSWLKVVSETGETAIASVTLS 414 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 + + G G DA A+ I S +L+ Y V G TDA E + Sbjct 415 VDSIERQASAPGSGPVDAAYKAIDSILQ----SNTELLLYSVNSITSG-TDAQGEVTVRL 469 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQP 513 K+ + Q G D +A+ A LN+IL P Sbjct 470 KKNGRIANGQ-----GADTDIVMASAKAYVNALNKILYP 503 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Hydrogenovibrio crunogenus XCL-2] Sequence ID: Q31I16.1 Length: 514 Range 1: 5 to 502 Score:168 bits(425), Expect:8e-45, Method:Compositional matrix adjust., Identities:153/521(29%), Positives:241/521(46%), Gaps:40/521(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 L I D TLRDGEQ+ G S + EK+ IAK L+KL V+ +E S+G+ E+VQ + Sbjct 5 LVIFDTTLRDGEQSPGASMTKEEKVRIAK-QLEKLRVNVIEAGFPAASQGDFESVQAVA- 62 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKT 119 +A + T + G + D ++ + + L G +H H+EK+L + Sbjct 63 -SAVKDST----VCGLARAVEN-DIVR--AGEAIKLANSGRIHTFIATSPIHMEKKLKMS 114 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 P E + ++ A + ED R+ D++ ++E I +PDT Sbjct 115 PDEVVERAVWAVKRARDFTDNVEFSPEDAG---RSELDFLCRVIEAAIDAGATTINIPDT 171 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G PE+ + L+ + P+ F H HND L+VANSL A+++G + + +ING Sbjct 172 VGYNVPEQFGELFHQLLNRIPNADKAIFSAHCHNDLGLAVANSLAAVKSGARQVECTING 231 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGNT LE +V + D + T I+ I ASRLV +G + N+ IVG + Sbjct 232 LGERAGNTALEEVVMAVRTRQDWFDVDTRIHTPEILAASRLVAGITGFAVQPNKAIVGTN 291 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SE 351 F+ +G+H DG K + E G LGK +G+++ +K+LG+ +E Sbjct 292 AFSHESGIHQDGVLKHRETYEIMRAEDVGWSTNKMVLGKHSGRSAFRSRLKELGIEFETE 351 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE-KVLTIKSCNIHSGIGIRPHAQ 410 L EL D+ + ED+ ++ D + R E + + + + + G P A Sbjct 352 QELSDAFISFKELADRKHEIYDEDIQALVTDNNTRRVENETFRLVALKVGTQTGDAPTAT 411 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 I L G+ SEG G DA A+ K+ + S L Y V G TD+L ET Sbjct 412 ITLWIDGEEKTASSEGGGVVDATFKAIEKLVD----SGATLELYSVSNVTNG-TDSLGET 466 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + K+ + Q G D A+ A LN+++ Sbjct 467 TVRMEKAGRIVNGQ-----GADTDIVTASAKAYINALNKLI 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Dechloromonas aromatica RCB] Sequence ID: Q47BI0.1 Length: 513 Range 1: 5 to 500 Score:168 bits(425), Expect:8e-45, Method:Compositional matrix adjust., Identities:141/516(27%), Positives:240/516(46%), Gaps:33/516(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 L I D TLRDGEQ+ G S + EK+ +A+ L+K+ VD +E A S G+ + + I + Sbjct 5 LVIFDTTLRDGEQSPGASMTKEEKIRVAR-QLEKMRVDVIEAGFAAASPGDFDAIHSIAQ 63 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 + + D + + IK + + ++ S H+EK+L TP + Sbjct 64 TIKDSTVCS-LARANENDIRRAGEAIKPAQSGRIHTFIATSPIHMEKKLRMTPDQ----- 117 Query 128 SFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 V+E A+K+ Y +D + R+ D++ + E + K I +PDT+G Sbjct 118 --VVEQAVKAIGWAREYTDDIEFSAEDAGRSDLDFLCRIFEEVIKAGATTINVPDTVGYN 175 Query 184 SPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P + + + LI++ P+ + + H HND L+V+NSL A+ G + + +INGLGER Sbjct 176 IPSQYAETMRQLIERVPNSDKVVWSVHCHNDLGLAVSNSLAAVLCGARQVECTINGLGER 235 Query 241 AGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGN LE +V + +++ +T I+ I AS+LV +G + N+ +VG + F Sbjct 236 AGNAALEEIVMAVRTRADVFPVETRIDTTQIVPASKLVSQITGYPVQPNKAVVGANAFAH 295 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQ 355 +G+H DG K + + G + LGK +G+ + +++LG+ L S+ L Sbjct 296 ESGIHQDGVLKHRETYEIMRAQDVGWTQNKLVLGKHSGRNAFKNRLQELGIELESDEALN 355 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 R EL D+ + EDL +++D ++ + + S G P A + L Sbjct 356 AAFARFKELADKKHEIFDEDLHALVSDDLVTPDQEYYKLVYSRVCSETGEMPRASVILNI 415 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTDALVETRITW 474 G HK ++G G DA A+ I S +L+ Y V I G V TR++ Sbjct 416 GGVEHKAEADGGGPVDATFKAIESIAG----SGAELLLYSVNAITTGTDAQGEVTTRLS- 470 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + D+ G D +A+ + LN++ Sbjct 471 ------KGDRIVNGNGADTDIVIASARSYLNALNKL 500 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pyrobaculum aerophilum str. IM2] Sequence ID: Q8ZW35.2 Length: 384 Range 1: 6 to 350 Score:164 bits(416), Expect:9e-45, Method:Compositional matrix adjust., Identities:111/355(31%), Positives:178/355(50%), Gaps:11/355(3%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 +++I D TLRDGEQ GV+ S SEKL IA L VD +E A VS E E ++ I Sbjct 6 VQIKIFDTTLRDGEQMPGVALSISEKLEIA-MALDDAGVDMIEAGFAAVSDDEKEAIKLI 64 Query 66 MEWAATEQLTERIEILGFVDGNKT-VDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 + R +++ K+ VD ++ +++L S HL+ +LG T +E Sbjct 65 ------SKEVSRAKVVSLARMTKSDVDAAAEADVDMIHLFIATSDIHLKYKLGITREEAL 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 + V+ YA G++I ED + R+ +++ + + + I +PDT+GV++ Sbjct 119 RRIEEVVSYAKSYGVEILFSAEDAT---RSDLEFLAKAYKTAIEAGADEINVPDTVGVMT 175 Query 185 PEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 P + L ++ P I H H+D+ ++VAN++ AI G +N GERAGN Sbjct 176 PSRMAYLIKYLRERLPPIPMHVHCHDDFGMAVANTVTAIENGADVAQVVVNNFGERAGNA 235 Query 245 PLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 LE +V +H +TNI + S+LV G + N+ +VGE+ F+ AG+H Sbjct 236 ALEEVVAAVHYLLGLRTNIKLEKLYSLSQLVSKLFGVPVPPNKAVVGENAFSHEAGIHVH 295 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 G P+ PE G +R LGK +G+ S+ +K LG+ SE ++ VL+ Sbjct 296 GVLNNPFTYEPMRPEDVGNRRRIVLGKHSGRHSVIWALKNLGVEPSEDLVNYVLD 350 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitrobacter winogradskyi Nb-255] Sequence ID: Q3SQ49.1 Length: 519 Range 1: 11 to 510 Score:167 bits(424), Expect:1e-44, Method:Compositional matrix adjust., Identities:145/521(28%), Positives:239/521(45%), Gaps:33/521(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EK+ +A+ +L + VD +E S G+ E V +I Sbjct 11 RVVIFDTTLRDGEQCPGATMTFEEKIEVAE-MLDGMGVDIIEAGFPIASVGDFEAVAEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + + D + + ++ + ++ S HL Q+ K+ E Sbjct 70 RNARNAVIAGLARAIPG-DIARAGEAVRHARRGRIHTFVSTSPIHLAHQMRKSEAEVLEI 128 Query 127 VSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 ++ ++ A +ED WS + R DY+ VE I LPDT+G Sbjct 129 ITATVKQARN-------LVEDVEWSAMDATRTPIDYLCKCVEAAIAAGATTINLPDTVGY 181 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P+E + ++ ++ P F H H+D L+VANSL + G + + ++ING+GE Sbjct 182 AVPDEYRRMFKTIRERVPSADKAIFSVHCHDDLGLAVANSLAGVEGGARQVESTINGIGE 241 Query 240 RAGNTPLEALVTTIHDKSNSK---TNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE +V I +++ N+ +T AS++V + + N+ IVG + F Sbjct 242 RAGNAALEEVVMAIKTRADVMPYWCNVESTMLTRASKMVSAATSFPVQYNKAIVGRNAFA 301 Query 297 QTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K + PE G K+ S +GK +G+ + +++LG L+E LQ Sbjct 302 HESGIHQDGMLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLEELGYKLAENQLQ 361 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 R L D+ K + ED+ ++ + T +++ + S + +G A ++L Sbjct 362 DAFVRFKALADRKKDIYDEDIIALVDEEMAATHDRI-KLSSLTVIAGTHGPQRATMKLTV 420 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 G+ E +EG+G DA N + RL KL Y+V G TDA E Sbjct 421 SGQTRIEEAEGNGPVDAVFNCI----KRLVPHEAKLELYQVHAVTQG-TDAQAEV----- 470 Query 476 KSLDLEED-QTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 S+ L +D + + PD VA+ A LN+I+ Q Sbjct 471 -SVRLSQDGRAMTSKAADPDTLVASAKAYLGALNKIVMKHQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitrobacter hamburgensis X14] Sequence ID: Q1QJV3.1 Length: 520 Range 1: 11 to 510 Score:167 bits(424), Expect:1e-44, Method:Compositional matrix adjust., Identities:145/521(28%), Positives:240/521(46%), Gaps:33/521(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G + + EKL +A+ +L + +D +E S G+ E V +I Sbjct 11 RVVIFDTTLRDGEQCPGATMTFEEKLEVAE-MLDDMGIDIIEAGFPIASVGDFEAVAEIA 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A + + D + + ++ + ++ S HL Q+ K+ E Sbjct 70 KNAKNAVIAGLARAIPG-DIARAGEAVRHARRGRIHTFVSTSPIHLAHQMRKSEAE---- 124 Query 127 VSFVIEYAIKSGLKINVYLED--WS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V+E + + +ED WS + R DY+ VE + LPDT+G Sbjct 125 ---VLEIITATVTQARNLVEDVEWSAMDATRTPIDYLCKCVETAIAAGATTVNLPDTVGY 181 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P+E + ++ ++ P+ F H H+D L+VANSL + G + + ++ING+GE Sbjct 182 AVPDEYRRMFRTIRERVPNADKAIFSVHCHDDLGLAVANSLAGVEGGARQVESTINGIGE 241 Query 240 RAGNTPLEALVTTIHDKSNSK---TNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE +V I + + N+ +T AS+LV + + N+ IVG + F Sbjct 242 RAGNAALEEVVMAIKTRGDVMPYWCNVESTMLTRASKLVSAATSFPVQYNKAIVGRNAFA 301 Query 297 QTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K + PE G K+ S +GK +G+ + +++LG L+E LQ Sbjct 302 HESGIHQDGMLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLEELGYKLAENQLQ 361 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 R L D+ K + ED+ ++ + + +++ + S + +G A ++L Sbjct 362 DAFVRFKALADRKKDIYDEDIVALVDEEMAASHDRI-KLTSLTVIAGTHGPQRATMKLTV 420 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 G+ E +EG+G DA N + RL KL Y+V G TDA E Sbjct 421 DGQTRIEEAEGNGPVDAVFNCI----KRLVPHEAKLDLYQVHAVTHG-TDAQAEV----- 470 Query 476 KSLDLEED-QTFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 S+ L +D + + PD VA+ A LN+I+ Q Sbjct 471 -SVRLSQDGRAMTSKAADPDTLVASAKAYLGALNKIVMKHQ 510 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia pseudomallei 668] Sequence ID: A3N7K7.1 Length: 515 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia pseudomallei 1106a] Sequence ID: A3NT94.1 Length: 515 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia pseudomallei 1710b] Sequence ID: Q3JUB9.1 Length: 515 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia pseudomallei K96243] Sequence ID: Q63VP3.1 Length: 515 Range 1: 4 to 440 Score:167 bits(423), Expect:1e-44, Method:Compositional matrix adjust., Identities:129/442(29%), Positives:209/442(47%), Gaps:16/442(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L+++ VD +E A S G+ + +Q I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAK-QLERMKVDVIEAGFAASSNGDFDAIQTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D + D +K + + ++ S H+EK+L TP + F Sbjct 63 SQVKDSTICS-LARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A K I ED G R+ D++ ++E + E I + DT+G PE Sbjct 122 ARLAVRFARKFTDNIEFSPED---GSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 V +L ++ P+ F H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + + + I+ I AS+LV +G + N+ +VG + F + Sbjct 239 NTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNI--HSGIGIRPHAQIELEY 415 R +L D+ + ED+ I+ + ++ K ++ S G RP A++ Sbjct 359 FARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAV 418 Query 416 QGKIHKEISEGDGGYDAFMNAL 437 G + G+G DA NA+ Sbjct 419 DGDEVAGEASGNGPVDATFNAI 440 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Brevibacillus brevis NBRC 100599] Sequence ID: C0Z9C8.1 Length: 512 Range 1: 4 to 500 Score:167 bits(422), Expect:2e-44, Method:Compositional matrix adjust., Identities:141/515(27%), Positives:243/515(47%), Gaps:28/515(5%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 +EI D TLRDGEQ+ GV+ ST+EK+ IA L+KL V+R+E A S G+ ++V ++ + Sbjct 4 IEIFDTTLRDGEQSPGVNISTNEKVEIA-LQLEKLGVNRMEAGFAAASPGDQKSVAEVAK 62 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 + + D +K + ++++ L++ S H + +L + +E Sbjct 63 RVKNATVVSLARAVKD-DMDKAYEALRNAQNASLHVFLATSPIHRQFKLNMSKEEVLARA 121 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 + YA K ++ ED + R D++ +VE + K + +PDT+G ++P + Sbjct 122 VEAVTYAKKYFTEVQFSAEDAA---RTEIDFLAEVVEAVIKAGATTVNIPDTVGYMTPYQ 178 Query 188 TFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 L ++ P I H H+D ++VANSL A+ G + +ING+GERAGN Sbjct 179 YGNIFRELKKRVPSTDLIRLSCHCHDDLGMAVANSLAAVEGGATQVEGTINGIGERAGNA 238 Query 245 PLEALVTTIHDK-----SNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 LE + + + + +K N+ EIA T S+LV +G + N+ +VG + F + Sbjct 239 ALEEVALALETRKDYYQATTKLNLKEIART--SQLVSRLTGMIVPGNKAVVGANAFAHES 296 Query 300 GVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K I PE G K + LGK +G+ + E + LG L + + Sbjct 297 GIHQDGVLKEVTTYEIIRPESVGFKSNKLVLGKHSGRHAFKEKLVDLGYHLEQEEVNAAF 356 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQG 417 L D+ K +T +D+ + D G + ++S + G P A + L G Sbjct 357 AAFKVLCDKKKEITDDDI-LALVDSKMVRGPEAFQLESVQLAYGNISVPTASVRLVRADG 415 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 + +E + G+G D+ A+ + T L+DY++ G+ DAL E + Sbjct 416 SVCEEAACGNGSVDSIYKAIDRATGEE----VSLVDYKILSVTHGQ-DALGEVFVRLQ-- 468 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQ 512 ++D GV D A+ A + +N+I++ Sbjct 469 ---QDDLIVTGRGVSTDVLEASAIAYVRAVNKIME 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia ambifaria AMMD] Sequence ID: Q0BDB9.1 Length: 514 Range 1: 4 to 439 Score:167 bits(422), Expect:2e-44, Method:Compositional matrix adjust., Identities:128/441(29%), Positives:210/441(47%), Gaps:15/441(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L +++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAKHL-ERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D + D +K + + ++ S H+EK+L TP + F Sbjct 63 GLVKDSTICS-LARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPDQVFEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A K + ED G R+ D++ ++E + E I + DT+G PE Sbjct 122 ARLAVRFARKFTDNVEFSPED---GSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 V +L ++ P+ F H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + + + ++ I S+LV +G + N+ +VG + F + Sbjct 239 NTSLEEIVMAVKTRKDYFGLDVGLDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSETELNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQIELEYQ 416 R +L D+ + ED+ I+++ S E+ S + S G +P A++ L Sbjct 359 FMRFKDLADRKSDIFDEDIIAIVSEESAFAQEQEHYKFVSLSQRSETGEQPQAKVVLALD 418 Query 417 GKIHKEISEGDGGYDAFMNAL 437 GK + G+G DA NA+ Sbjct 419 GKEVTGEARGNGPVDATFNAI 439 >RecName: Full=Homocitrate synthase; Short=HCS [Sulfurisphaera tokodaii str. 7] Sequence ID: Q971S5.1 Length: 460 Range 1: 2 to 435 Score:165 bits(418), Expect:2e-44, Method:Compositional matrix adjust., Identities:134/450(30%), Positives:216/450(48%), Gaps:28/450(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ ILD TLR+GEQT GV F+ +++ IAK L + V +E VS E +++IM Sbjct 2 KVGILDSTLREGEQTPGVVFTIDQRVEIAK-ALSDVGVQMIEAGHPAVSSDIYEGIKRIM 60 Query 67 EWAATEQLTERIEILGFVDG-NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 + +T EI+G K ++ + + + S HL+ + T +E Sbjct 61 KLKREGLITS--EIVGHSRAVKKDIEVAAELEVDRIAIFYGVSDIHLKAKHHVTREEALN 118 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 ++ I YA G+K+ ED G R DY+ + + +R+ + DT+G+L P Sbjct 119 IIAETISYAKSHGVKVRFTAED---GSRTDLDYLIKVCKTARDAGADRVSIADTVGILYP 175 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 +T + +L+++ P + F+ H HND L+VAN+L AI G +H ++NGLGER G P Sbjct 176 TKTRELFSTLVREVPGLEFDIHAHNDLGLAVANALAAIEGGATIIHTTVNGLGERVGIVP 235 Query 246 LEALVTTI-HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 L+ + I + +N+ + + + LVE +SG + N PI G+ F AG+H Sbjct 236 LQVIAAAIKYHFGIEVVKLNK--LQQLASLVEKYSGIPMPPNYPITGDYAFIHKAGIHVA 293 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 G + PE FGR R Y + K GK ++ + ++LG+ LS+V L +VL + I+ Sbjct 294 GVLNDPSTYEFMPPETFGRSRDYVIDKYTGKHALKDRFEKLGVKLSDVELDQVLAK-IKS 352 Query 365 GDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSC-NIHSGIGIRPHAQIELEYQGKIH--- 420 + DL I V+GR VL K NI + I ++ + + Y + Sbjct 353 NPNVRFYRDVDLLEIAESVTGR----VLKPKPPENIEALISVKCESNV---YTTAVTRRL 405 Query 421 ------KEISEGDGGYDAFMNALTKITNRL 444 KE+ E G YD + K N L Sbjct 406 SVIPGVKEVMEISGDYDILVKVEAKDPNEL 435 >RecName: Full=2-isopropylmalate synthase 2; AltName: Full=Alpha-IPM synthase 2; AltName: Full=Alpha-isopropylmalate synthase 2 [Caldanaerobacter subterraneus subsp. tengcongensis MB4] Sequence ID: Q8RCF9.1 Length: 384 Range 1: 11 to 342 Score:163 bits(413), Expect:2e-44, Method:Compositional matrix adjust., Identities:111/349(32%), Positives:184/349(52%), Gaps:24/349(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I+D TLRDGEQT GV F+ +EK+ IA+ +L ++ +D++E+ + E ETV KI Sbjct 11 IVDTTLRDGEQTAGVVFANNEKIRIAQ-MLDEIGIDQLEVGIPTMGGDEKETVAKIA--- 66 Query 70 ATEQLTERIEILGFVDGNKTVDWIKD------SGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 +L + I+ + N+ V +KD G + + S H+E +L KT + Sbjct 67 ---KLGLKASIMAW---NRAV--VKDVQESLECGVDAVAISISTSDIHIEHKLKKTRQWV 118 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 ++ + +A K G+ ++V ED S R +++ + +R+ DT+G L Sbjct 119 LDSMTEAVRFAKKEGVYVSVNAEDAS---RTDMNFLIEFARCAKQAGADRLRFCDTVGFL 175 Query 184 SPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 P +T++ V + I+ DI E H HND+ ++ AN+L ++AG K + ++NGLGERAGN Sbjct 176 DPFKTYEMVKA-IKDAVDIEIEMHTHNDFGMATANALAGVKAGAKFVGVTVNGLGERAGN 234 Query 244 TPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 LE +V + I+ E S V + SG+ + ++ IVG++VF +G+H Sbjct 235 AALEEVVMALKYVYKMDLGIDTSRFREISEYVALASGRPLPPSKAIVGKNVFAHESGIHV 294 Query 304 DGDKKGNLYANPIL-PERFGRKRSYALGKLAGKASISENVKQLGMVLSE 351 DG K N Y + P+ G +R +GK +G A++ K+ G VL+E Sbjct 295 DGALK-NPYTYEVFDPQEVGLERQIVIGKHSGTAALINKFKEYGRVLTE 342 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Chromobacterium violaceum ATCC 12472] Sequence ID: Q7P0H2.1 Length: 512 Range 1: 4 to 500 Score:166 bits(421), Expect:3e-44, Method:Compositional matrix adjust., Identities:150/523(29%), Positives:231/523(44%), Gaps:45/523(8%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 RL I D TLRDGEQ+ G S S EK+ IA+ L++L VD +E A S G+ + + I Sbjct 4 RLYIFDTTLRDGEQSPGASMSKEEKIRIAR-QLERLGVDIIEAGFAAASPGDFDAIHAIA 62 Query 67 EW------AATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 E + + ER D + IK + ++ S H+EK+L +P Sbjct 63 ETIKDSTVCSLARANER-------DVRAAGEAIKPAARGRIHTFIATSPIHMEKKLRMSP 115 Query 121 KEFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFL 176 E V++ A+K+ Y +D + R+ D++ + + K + + Sbjct 116 DE-------VVDAAVKAVKIAREYTDDVEFSAEDALRSDIDFLARIFGEVIKAGATTLNV 168 Query 177 PDTLGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHAS 233 PDT+G P T LI + P + + H HND ++VANSL A+ G + + + Sbjct 169 PDTVGYAVPRLTEAFFRELIARTPGGDKVVWSAHCHNDLGMAVANSLAAVLGGARQVECT 228 Query 234 INGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 INGLGERAGN LE +V + D + ++ I AS+LV +G + N+ IV Sbjct 229 INGLGERAGNASLEEVVMAVKTRRDVFGVDSRVDATQIVPASKLVSTVTGYPVQPNKAIV 288 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL 349 G + F +G+H DG K + E G LGKL+G+ + + +LG+VL Sbjct 289 GANAFAHESGIHQDGVLKHRETYEIMSAESVGWSANRLTLGKLSGRNAFKTKLSELGIVL 348 Query 350 -SEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPH 408 SE L R EL D+ + + EDL +++D + + S + S G P Sbjct 349 DSEEALNAAFARFKELADKKREIFDEDLHALVSDEMVTIEREDYKLVSLKVVSETGEPPL 408 Query 409 AQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTDAL 467 A I G+ S G G DA A+ K+ S +L Y V I G ++ Sbjct 409 ASIVFVEHGQEQHGESSGSGPVDAAFKAIEKVVG----SGAELELYSVNAITKGTESQGE 464 Query 468 VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 V R++ E + G D VA+ A LN++ Sbjct 465 VTVRLS-------REGRIVNGQGADTDIIVASAKAYLSALNKL 500 >RecName: Full=Homocitrate synthase AksA; AltName: Full=(R)-homo(2)citrate synthase; AltName: Full=(R)-homo(3)citrate synthase [Methanothermobacter thermautotrophicus str. Delta H] Sequence ID: O27667.1 Length: 391 Range 1: 15 to 387 Score:163 bits(412), Expect:4e-44, Method:Compositional matrix adjust., Identities:119/386(31%), Positives:189/386(48%), Gaps:16/386(4%) Query 3 KVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV 62 K R+ I D TLRDGEQT GV T EKL IA+ L +L + ++E VS+ E +V Sbjct 15 KFPDRITIYDTTLRDGEQTPGVCLGTEEKLEIAR-KLDELGIHQIESGFPVVSEQERVSV 73 Query 63 QKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKE 122 + I A E L I L + I V+ + LH L+ +L T +E Sbjct 74 KSI----ANEGLNAEILALCRTKKDDIDAAIDCDVDGVITFMATSDLH-LKHKLKLTREE 128 Query 123 FFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 IEYA GL + ED + R D++K + +R+ + DT+G Sbjct 129 ALNVCMNSIEYAKDHGLFLAFSAEDAT---RTDLDFLKQIYRKAENYGADRVHIADTVGA 185 Query 183 LSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 +SP QG+D L+++ + H HND+ ++++NS+ + AG + ++NG+GE Sbjct 186 ISP----QGMDYLVRELRRDIKVDIALHCHNDFGMALSNSIAGLLAGGTAVSTTVNGIGE 241 Query 240 RAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 RAGNT LE L+ + N + E SRLVE + ++ N+PIVG +VF + Sbjct 242 RAGNTSLEELIMALRIIYEVDLGFNIGVLYELSRLVEKHTRMKVPENKPIVGRNVFRHES 301 Query 300 GVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 G+H D + L P LPE G +R LGK +G ++ +++ G+ ++ L +++E Sbjct 302 GIHVDAVIEEPLTYEPFLPEMIGHQRKIVLGKHSGCRAVKAKLEEYGIDVTRDELCRIVE 361 Query 360 RVIELGDQNKLVTPEDLPFIIADVSG 385 V + ++ K + E I+ V G Sbjct 362 EVKKNREKGKYINDELFYRIVKSVRG 387 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Burkholderia ambifaria MC40-6] Sequence ID: B1YTR7.1 Length: 514 Range 1: 4 to 439 Score:166 bits(419), Expect:4e-44, Method:Compositional matrix adjust., Identities:127/441(29%), Positives:209/441(47%), Gaps:15/441(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +L I D TLRDGEQ+ G S + EK+ IAK L +++ VD +E A S G+ + + I Sbjct 4 KLIIFDTTLRDGEQSPGASMTKEEKIRIAKHL-ERMKVDVIEAGFAASSNGDFDAIHTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + D + D +K + + ++ S H+EK+L TP + F Sbjct 63 GLVKDSTICS-LARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPDQVFEQ 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + +A K + ED G R+ D++ ++E + E I + DT+G PE Sbjct 122 ARLAVRFARKFTDNVEFSPED---GSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPE 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIR-AGVKGLHASINGLGERAG 242 V +L ++ P+ F H HND ++VANSL ++ G + + +INGLGERAG Sbjct 179 LYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAG 238 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 NT LE +V + + + ++ I S+LV +G + N+ +VG + F + Sbjct 239 NTSLEEIVMAVKTRKDYFGLDVGLDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHAS 298 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + E G LGKL+G+ + + +++LG+ L SE L Sbjct 299 GIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSETELNAA 358 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV-LTIKSCNIHSGIGIRPHAQIELEYQ 416 R +L D+ + ED+ I+++ S E+ S + S G +P A++ Sbjct 359 FMRFKDLADRKSEIFDEDIIAIVSEESALAQEQEHYKFVSLSQRSETGEQPQAKVVFALD 418 Query 417 GKIHKEISEGDGGYDAFMNAL 437 GK + G+G DA NA+ Sbjct 419 GKEVTGEARGNGPVDATFNAI 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitrosomonas eutropha C91] Sequence ID: Q0AGN5.1 Length: 510 Range 1: 4 to 470 Score:166 bits(419), Expect:5e-44, Method:Compositional matrix adjust., Identities:144/485(30%), Positives:229/485(47%), Gaps:33/485(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 RL I D TLRDGEQ+ G S + EK+ IA+ L+++ VD +E SKG+ E V+ + Sbjct 4 RLVIFDTTLRDGEQSPGASMTMEEKVRIAR-QLERMGVDVIEAGFPAASKGDFEAVKAVA 62 Query 67 EWAATEQ---LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 E + L+ IE D N+ + ++ + ++ S H++ +L +P Sbjct 63 EAVSNSTVCGLSRAIE----ADINRAGEALQANQNMRIHTFIATSPIHMKNKLRMSPDR- 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 VIE AIK+ Y ++ + R+ D++ ++E + + +PDT Sbjct 118 ------VIEQAIKAVKWARQYTDNVEFSPEDAGRSEIDFLCRILEAVIDAGARTLNIPDT 171 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P++ + +L ++ P+ F H HND L+VANSL A+ G + + +ING Sbjct 172 VGYTMPDQFGGLIRTLRERIPNSDKAVFSVHCHNDLGLAVANSLSAVMNGARQVECTING 231 Query 237 LGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 LGERAGN LE +V + + + T I+ I S+LV +G + N+ IVG + Sbjct 232 LGERAGNAALEEVVMAVRTRQDYFPCDTRIDTTQIVSTSKLVSGITGFPVQPNKAIVGAN 291 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SE 351 F +G+H DG K + E G LGK +G+ + +K+LG+ L SE Sbjct 292 AFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLKELGIELESE 351 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L + R +L D+ + EDL +++D + E+ + S HS G P AQ+ Sbjct 352 EKLNTIFIRFKDLADKKHEIFDEDLHALVSD-EAQIPEEHYRLLSLVAHSETGEIPFAQV 410 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETR 471 + + SEG G DA A+ KI N S +L + V G TDAL E Sbjct 411 VIATGNNEQQAESEGSGPVDATFRAIEKILN----SKAELQLFSVNNITSG-TDALGEVT 465 Query 472 ITWNK 476 + K Sbjct 466 VRLQK 470 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter fetus subsp. fetus 82-40] Sequence ID: A0RQK7.1 Length: 506 Range 1: 5 to 502 Score:165 bits(418), Expect:6e-44, Method:Compositional matrix adjust., Identities:148/519(29%), Positives:243/519(46%), Gaps:34/519(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ + D TLRDGEQ+ G S +T EK+ IA L++L VD +E A S G+ + + +I Sbjct 5 KIIVFDTTLRDGEQSPGASMNTEEKIQIA-LQLERLGVDVMEAGFAAASPGDFDAINQIA 63 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + ++ L D + I + + ++ S H+E +L TP E Sbjct 64 KQIHSIRIASLARALE-KDIKAAGEAISPAKNRRIHTFIATSPIHMEHKLKMTPDEVIKR 122 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++YA + ED R+ ++K + + + + LPDT+G P+ Sbjct 123 AVEAVKYAKTFVDDVEFSCEDAG---RSDIVFLKEICAAVVEAGARTLNLPDTVGFRMPD 179 Query 187 ETFQGVDSLIQKYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 E + V S++ D H HND L+VAN+L +I+AG + + +INGLGERAGN Sbjct 180 EIYNMVKSMVDFIGDRAIISVHNHNDLGLAVANTLASIKAGARQVECTINGLGERAGNAA 239 Query 246 LEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 LE +V TI +S+ T+I I SRLV +G N+ IVG++ F +G+ Sbjct 240 LEEIVMTIRTRSDEFAPLYTDIVTKEIYATSRLVASITGIEPQPNKAIVGKNAFAHESGI 299 Query 302 HADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLER 360 H DG K I E G K S LGK +G+ + + + LG L + + + + Sbjct 300 HQDGMLKCAQTYEIIKAEDIGAEKNSLVLGKHSGRHAFKDKLINLGFDLDDNEINEAFIK 359 Query 361 VIELGDQNKLVTPEDLPFIIADVSGRTGE----KVLTIKSCNI-HSGIGIRPHAQIELEY 415 EL D+ K + +D+ +++ + E + L+ SCN HS A + +++ Sbjct 360 FKELCDKKKEIFDDDIRALVSHEIIKIPEIYSIQTLSTSSCNAGHSS------AAVSIKF 413 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 I + + G+G DA + +I+ GIS +L DY+V GK DAL + + Sbjct 414 SDNIISDAALGNGTADAIFKVIDRIS---GIS-GELKDYKVNAVSQGK-DALAKITVKV- 467 Query 476 KSLDLEEDQTFKTM--GVHPDQTVAAVHATEKMLNQILQ 512 + E + T+ G+ D +A+ A LN L Sbjct 468 ----VFEGSSCATIGHGLDIDTMMASAKAYVSALNSYLS 502 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thermotoga sp. RQ2] Sequence ID: B1L8U2.1 Length: 513 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thermotoga maritima MSB8] Sequence ID: Q9WZ23.1 Length: 513 Range 1: 3 to 500 Score:165 bits(417), Expect:9e-44, Method:Compositional matrix adjust., Identities:149/516(29%), Positives:248/516(48%), Gaps:29/516(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R++I D TLRDGEQ+ G S S EK+ +A +L+ L VD +E S + E V+++ Sbjct 3 RIKIFDTTLRDGEQSPGASMSIEEKVEMA-LMLEDLGVDLIEAGFPVSSPVQFEAVKRVA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKD--SGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 A + + + D + + +KD +++++ S H + +L +E Sbjct 62 S-AVQKPIVVGLARCVEKDIDAAYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEKEEIL 120 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 + + YA + + ED S R ++ + + I +PDT+G Sbjct 121 ERIRRYVGYAKQFFDLVEFSAEDAS---RTEVPFLIEAYKTAIEAGATTINVPDTVGYAL 177 Query 185 PEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 P+E + + +L + P ++ H HND L+VANSL A++ G + ++NG+GERA Sbjct 178 PDEFGELIKTLREGVPGIENVDLSVHCHNDLGLAVANSLAAVQNGATQVEVTLNGIGERA 237 Query 242 GNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GN LE V + DK +T I I ASRL+ +G S N+PIVGE+VF Sbjct 238 GNCALEEFVMILKVRKDKLPYETGIKTELIYPASRLLTHITGLIPSRNKPIVGENVFLHE 297 Query 299 AGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K + P GR + LG+ +GK ++ + ++ G+ L E QKV Sbjct 298 SGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLETYGIKLDEETFQKV 357 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGR--TGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 E+ EL D+ K V +DL I+++V G K++ ++H+G + P A + L+ Sbjct 358 FEKFTELADRKKEVYDDDLFSIVSEVLREPINGYKLVHF---HVHTGNTLLPTAAVVLQV 414 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 + + G+G DA A+ K LGI PKL +Y ++ GK +A E ++T Sbjct 415 GNEKREAAEAGNGPVDAIFKAIDKA---LGIQ-PKLEEYIIQAVGTGK-NAQGEVKLTLR 469 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 +++ + GV D A+ A +N+ L Sbjct 470 I-----DNELYSGRGVSTDIVEASAIAYINAINKYL 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Geobacillus sp. WCH70] Sequence ID: C5D5M0.1 Length: 515 Range 1: 3 to 463 Score:165 bits(417), Expect:1e-43, Method:Compositional matrix adjust., Identities:143/477(30%), Positives:230/477(48%), Gaps:30/477(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ+ G++ + EKL IA+ L++L VD +E SKG+ + V++I Sbjct 3 KINIFDTTLRDGEQSAGINLNLQEKLEIAR-QLERLGVDIIEAGFPASSKGDFQAVKQIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 E T +T + V + W +K L+L S H++ +L TP++ Sbjct 62 ETIKTCSVTG---LARSVQSDIDAAWEALKGGAEPRLHLFIATSPIHMKYKLQMTPEQ-- 116 Query 125 TDVSFVIEYAIKSGLKINVYLE--DWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 VIE A++S Y WS + R+ ++ ++ + K I +PDT+ Sbjct 117 -----VIETAVESVKYAKRYFPIVQWSAEDACRSELPFLAKIITEVIKAGATVINIPDTV 171 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G ++P+E L P+I H H+D ++VANSL AI G + +ING+ Sbjct 172 GYITPKEYGNIFTFLSNNVPNIEKVSLSAHCHDDLGMAVANSLAAIEHGATQIEGTINGI 231 Query 238 GERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE + ++ D ++T +N I S LV +G I N+ ++G++ Sbjct 232 GERAGNAALEEIAVALYIRKDYYQAETRLNLQEIKRTSNLVSKLTGVVIPPNKAVIGKNA 291 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K I PE G + S LGK +G+ ++ V++LG LS+ Sbjct 292 FAHESGIHQDGVLKEKTTYEIISPELVGVQSNSMVLGKHSGRHALRNRVEELGYTLSDEE 351 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 + K+ R EL D+ K +T +DL +I + + + S + G P A + L Sbjct 352 VNKLFVRFKELADKKKDITDDDLVALIFEEKFDHFKDFYQLSSLQVQYGTNQIPTAVVVL 411 Query 414 -EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + QG +E + G G +A N L R + L+DY + GG+ DAL + Sbjct 412 KDGQGNEIQEAATGAGSVEALYNTL----ERCFKTSVTLLDYRIESVSGGR-DALAQ 463 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thermotoga petrophila RKU-1] Sequence ID: A5IJM2.1 Length: 513 Range 1: 3 to 500 Score:165 bits(417), Expect:1e-43, Method:Compositional matrix adjust., Identities:154/517(30%), Positives:251/517(48%), Gaps:31/517(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R++I D TLRDGEQ+ G S S EK+ +A +L+ L VD +E S + E V+++ Sbjct 3 RIKIFDTTLRDGEQSPGASMSVEEKVEMA-LMLEDLGVDLIEAGFPVSSPVQFEAVKRVA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKD--SGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 A + + + D + + +KD +++++ S H + +L +E Sbjct 62 S-AVQKPIVVGLARCVEKDIDAVYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEKEEIL 120 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 + + YA + + ED S R ++ + + I +PDT+G Sbjct 121 ERIRRYVGYAKQFFDLVEFSAEDAS---RTEVPFLIEAYKTAIEAGATTINVPDTVGYAL 177 Query 185 PEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 P+E + + +L + P ++ H HND L+VANSL A++ G + ++NG+GERA Sbjct 178 PDEFGELIKTLREGVPGIENVDLSVHCHNDLGLAVANSLAAVQNGATQVEVTLNGIGERA 237 Query 242 GNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GN LE V + DK +T I I ASRL+ +G S N+PIVGE+VF Sbjct 238 GNCALEEFVMILKVRKDKLPYETGIKTELIYPASRLLTHITGLIPSRNKPIVGENVFLHE 297 Query 299 AGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K + P GR + LG+ +GK ++ + ++ G+ L E QKV Sbjct 298 SGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLESYGIKLDEETFQKV 357 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGR--TGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 E+ EL D+ K V +DL I+++V G K++ ++H+G + P A + L+ Sbjct 358 FEKFTELADRKKEVYDDDLFSIVSEVLREPINGYKLVHF---HVHTGNTLLPTAAVVLQV 414 Query 416 QGKIHKEISE-GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 G KE +E G+G DA A+ K LGI PKL +Y ++ GK +A E ++T Sbjct 415 -GDEKKEAAEAGNGPVDAIFKAIDKA---LGIQ-PKLEEYIIQAVGTGK-NAQGEVKLTL 468 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + +L + GV D A+ A +N+ L Sbjct 469 RINGEL-----YSGRGVSTDIVEASAIAYINAINKYL 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Gloeobacter violaceus PCC 7421] Sequence ID: Q7NI93.1 Length: 538 Range 1: 3 to 514 Score:165 bits(418), Expect:1e-43, Method:Compositional matrix adjust., Identities:149/540(28%), Positives:243/540(45%), Gaps:62/540(11%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + RL I D TLRDGEQ+ G + + EK+ IA+ L +L VD +E A S G+ E V++ Sbjct 3 QDRLIIFDTTLRDGEQSPGATLNADEKVEIAR-QLARLGVDVIEAGFAYASPGDFEAVER 61 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKV------LNLLTKGSLH-------- 110 + TE DG + + + + +G +H Sbjct 62 VARTVGTE------------DGPVICSLARAIRSDIQAAAEAIRPAARGRIHTFISTSDI 109 Query 111 HLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH 170 HLE QL K+ E + ++ +A G +V G R++P+Y+ ++E Sbjct 110 HLEHQLRKSRAEVLAIAAEMVAFA--KGFVDDVEFSPMDAG-RSAPEYLYRVLEAAIAAG 166 Query 171 IERIFLPDTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGV 227 + +PDT+G L+P E +G+ ++ H HND L+VANSL AI G Sbjct 167 ATTVNIPDTVGYLTPAEFGGLIRGITQNVRGIERAVISVHCHNDLGLAVANSLAAIENGA 226 Query 228 KGLHASINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASR 273 + + ++NG+GERAGN LE +V +H D + + I+ I ++SR Sbjct 227 RQIECTVNGIGERAGNCSLEEIVMALHVRRQFFNPIFGRPADSTVPLSTIDTRQIYKSSR 286 Query 274 LVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKL 332 LV +G + N+ IVG + F +G+H DG K L + E G + LGK Sbjct 287 LVSHLTGMLVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIMDAETVGVNENRIVLGKH 346 Query 333 AGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVL 392 +G+ + + +LG L + L + R EL D+ K V+ D+ +I+D R + Sbjct 347 SGRNAFRTRLVELGYELGDADLNRAFLRFKELADKKKTVSDWDIEAVISD-EIRLIPEAY 405 Query 393 TIKSCNIHSGIGIRPHAQIELEYQGKIHK-EISEGDGGYDAFMNALTKITNRLGISIP-K 450 ++ + G P A + L + + + + G G DA A+ NRL I +P + Sbjct 406 RLEQVQVSCGEPGLPTATVRLTGPDGVERVDAAVGTGPVDAVYKAI----NRL-IELPNE 460 Query 451 LIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 LI++ V+ G DA+ E I ++ +TF + D VA+ A LN++ Sbjct 461 LIEFSVQSVTAG-IDAMGEVTIRVR-----QDGRTFSGHAANTDIIVASARAYLNALNKL 514 >RecName: Full=Homocitrate synthase AksA; AltName: Full=(R)-homo(2)citrate synthase; AltName: Full=(R)-homo(3)citrate synthase [Methanocaldococcus jannaschii DSM 2661] Sequence ID: Q57926.3 Length: 406 Range 1: 34 to 399 Score:162 bits(410), Expect:1e-43, Method:Compositional matrix adjust., Identities:116/384(30%), Positives:189/384(49%), Gaps:28/384(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQT GV F+ +KL IA+ L +L + ++E VS+ E + V+ I Sbjct 34 IYDTTLRDGEQTPGVCFTKEQKLEIAR-KLDELGLKQIEAGFPIVSEREADIVKTI---- 88 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A E L I L D +K ++ D ++ + LH K K+ E Sbjct 89 ANEGLNADILALCRALKKDIDKAIECDVDG---IITFIATSPLHLKYKFNNKSLDEILEM 145 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH-------IERIFLPDT 179 +EYA + GL + ED + ++ +E L K H +R+ + DT Sbjct 146 GVEAVEYAKEHGLFVAFSAEDAT----------RTPIEDLIKVHKAAEEAGADRVHIADT 195 Query 180 LGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 G +P+ +L + H H HND+ +V NS+ + G K + ++NG+GE Sbjct 196 TGCATPQSMEFICKTLKENLKKAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGE 255 Query 240 RAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 RAGN LE L+ + + +N + E R+VE +SG ++ N+PIVGE VF + Sbjct 256 RAGNAALEELIMALTVLYDVDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHES 315 Query 300 GVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 G+H D + L P LPE+ G KR+ LGK +G +++ +K +G+ +L ++++ Sbjct 316 GIHVDAVIENPLTYEPFLPEKIGLKRNILLGKHSGCRAVAYKLKLMGIDYDREMLCEIVK 375 Query 360 RVIELGDQNKLVTPEDLPFIIADV 383 +V E+ ++ K +T E I+ +V Sbjct 376 KVKEIREEGKFITDEVFKEIVEEV 399 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thermotoga neapolitana DSM 4359] Sequence ID: B9KB95.1 Length: 513 Range 1: 3 to 500 Score:164 bits(414), Expect:2e-43, Method:Compositional matrix adjust., Identities:151/522(29%), Positives:252/522(48%), Gaps:41/522(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R++I D TLRDGEQ+ G S S EK+ +A +L+ L VD +E S + E V+++ Sbjct 3 RIKIFDTTLRDGEQSPGASMSVEEKVEMA-LMLEDLGVDLIEAGFPVSSPVQFEAVKRVA 61 Query 67 EWAATEQLTERIEILGFV-----DGNKTVDWIKD--SGAKVLNLLTKGSLHHLEKQLGKT 119 E +R ++G D + + +KD +++++ S H + +L Sbjct 62 EA------VQRPIVVGLARCVEKDIDAAYEALKDRPKDKRMIHVFIATSPIHRKYKLRME 115 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 +E V + YA + + ED S R ++ + + I +PDT Sbjct 116 KEEILERVRKYVTYARQFFDLVEFSAEDAS---RTEVPFLIEVYRTAIESGATTINVPDT 172 Query 180 LGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P+E + + +L + P ++ H HND L+VANS+ A++ G + ++NG Sbjct 173 VGYALPDEFGELIRTLKEGVPGIENVDLSVHCHNDLGLAVANSIAAVQNGATQVEVTLNG 232 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 +GERAGN LE V + D+ +T I I ASRL+ +G + N+PIVGE+ Sbjct 233 IGERAGNCALEEFVMALKVRKDRLPYETGIRTELIYPASRLLTHITGLIPARNKPIVGEN 292 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGMVLSEV 352 VF +G+H DG K + P GR + LG+ +GK ++ + ++ G+ L + Sbjct 293 VFLHESGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLESYGIKLDDE 352 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADV--SGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 QKV E+ EL D+ K V +DL I+++V G +++ ++H+G + P A Sbjct 353 TFQKVFEKFTELADRKKEVYDDDLFSIVSEVLKEPLNGYRLVHF---HVHTGNTLLPTAA 409 Query 411 IELEYQGKIHKEISE-GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + L+ G KE +E G+G DA A+ K LG+ PKL +Y ++ GK +A E Sbjct 410 VVLQV-GNEKKEAAETGNGPVDAIFKAIDKA---LGLQ-PKLEEYIIQAVGTGK-NAQGE 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 ++T +L + GV D A+ A +N+ L Sbjct 464 VKLTLKIDGEL-----YSGRGVSTDIVEASAIAYINAINKYL 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Psychromonas ingrahamii 37] Sequence ID: A1SRG8.1 Length: 519 Range 1: 7 to 500 Score:164 bits(414), Expect:3e-43, Method:Compositional matrix adjust., Identities:150/518(29%), Positives:238/518(45%), Gaps:41/518(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA F L++L VD +E+ S G+ E+V+ I Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-FALERLGVDVMEVGFPISSPGDFESVKTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A E R+ L D + + +K + A ++ S H+E +L +T Sbjct 62 AREIKNSRVCGLSRALPKDIDAAWNALKGADAFRIHTFISTSTIHVENKLKRT------- 114 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V+E I + Y +D + R D + +VE K I +PDT+G Sbjct 115 FDAVLEMGINAVKHARNYTDDVEFSCEDAGRTPIDNLCRIVEEAIKAGATTINIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P E + +L + P+I H H+D +SVANS+ A+ G + + ++NGLGE Sbjct 175 TYPSEFGGIIKTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVENGARQIECTMNGLGE 234 Query 240 RAGNTPLE---ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE ++ T DK TN+N + I+ S+LV I AN+ IVG + F+ Sbjct 235 RAGNCSLEEVAMILQTRKDKLGFTTNVNPMEISRTSQLVSQLCNMPIQANKAIVGANAFS 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 ++G+H DG K + PE G L +G+ I +++LG ++ L+ Sbjct 295 HSSGIHQDGVLKSQNTYEIMTPESVGISTNKLNLTSRSGRHVIQHRMQELGYRDTDYDLE 354 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 ++ +EL D+ V DL ++ + + ++S N+ SG G+ A I + Sbjct 355 QLYASFVELADKKGQVFDYDLEALMFFNKVDSDPQHYRLESINVQSGSGLVATATIVMSI 414 Query 416 -QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRI 472 + K E + G+G DA L +I+ G+ I + DY + GK DAL V+ Sbjct 415 GEDKKVVEAATGNGPIDAAYQCLMRIS---GLDI-NMDDYHINAKGAGK-DALGQVDIVA 469 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 T+N Q F +G+ D ++ A ++N I Sbjct 470 TYNG-------QKFHGLGLSTDIIESSTKAMVHVMNHI 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitrosospira multiformis ATCC 25196] Sequence ID: Q2YBW0.1 Length: 510 Range 1: 5 to 499 Score:163 bits(413), Expect:3e-43, Method:Compositional matrix adjust., Identities:149/520(29%), Positives:244/520(46%), Gaps:42/520(8%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 L I D TLRDGEQ+ G S + EK+ IA+ L+++ VD +E S G+ E V+ + Sbjct 5 LIIFDTTLRDGEQSPGASMTREEKVRIAR-QLERMRVDVIEAGFPAASNGDFEAVKAVAA 63 Query 68 WAATEQ---LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 L IE D + + ++ + + ++ S H+EK+L +P + Sbjct 64 AIKGSTICGLARAIE----GDIRRAGEALRGANSARIHTFIATSPIHMEKKLRMSPDQ-- 117 Query 125 TDVSFVIEYAIKSGLKINVYLEDWS----NGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 V+E A+K+ Y +D + R+ ++ ++E + + +PDT+ Sbjct 118 -----VVEQAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTV 172 Query 181 GVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G P++ + + +L ++ P+ + F H HND L+VANSL A+ G + + ++NGL Sbjct 173 GYTMPQQFGELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGL 232 Query 238 GERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE +V + + + T I+ + I AS+LV +G + N+ IVG + Sbjct 233 GERAGNASLEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANA 292 Query 295 FTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEV 352 F +G+H DG K + E G LGK +G+ + + +LG+ L SE Sbjct 293 FAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLAELGIELESEE 352 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE--KVLTIKSCNIHSGIGIRPHAQ 410 L R EL D+ + EDL +++D + E K+L++ + HS G PHA Sbjct 353 TLNATFMRFKELADKKHDIFDEDLHALVSDDAAALQEHYKLLSLTA---HSETGETPHAS 409 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 I + +G+ + S+G G DA A+ KI N S +L Y V G TD+ E Sbjct 410 IVIGEEGRESRAESDGSGPVDATFRAIEKILN----SGVELQLYSVNAITSG-TDSQGEV 464 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQI 510 + KS + G D VA+ A LN++ Sbjct 465 TVRLQKS-----GRIVNGNGADTDIVVASAKAYLSALNKL 499 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Photorhabdus laumondii subsp. laumondii TTO1] Sequence ID: Q7N129.1 Length: 520 Range 1: 7 to 505 Score:164 bits(414), Expect:3e-43, Method:Compositional matrix adjust., Identities:146/522(28%), Positives:242/522(46%), Gaps:38/522(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S +EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLCVNEKLQIA-LALERMGVDIMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A +++ S H+E +L KT + Sbjct 62 AKQIKNSRVCALARCVEKDIDVAAEALKVADAFRIHVFLATSDLHIESKLKKTFEN---- 117 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V+E A +S + Y +D + R D + +VE+ K I +PDT+G Sbjct 118 ---VMEMATQSIKRARRYTDDVEFSCEDAGRTPIDNLCRIVENAIKAGATTINIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 +P + + +LI++ P+I H H+D +SVANS+ A+++G + + +INGLGE Sbjct 175 TTPYQFGGIITNLIERVPNIDKAIISVHCHDDLGMSVANSITAVQSGARQIEGTINGLGE 234 Query 240 RAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE ++ I + TNIN I S+LV I AN+ IVG + F+ Sbjct 235 RAGNCSLEEVIMAIKVRQQMLGVYTNINHQEIYRTSQLVSQLCNMPIPANKAIVGSNAFS 294 Query 297 QTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQ 355 ++G+H DG K + PE G K L +G+A++ ++++G + L Sbjct 295 HSSGIHQDGVLKNRETYEIMTPESIGLKEIQLNLTSRSGRAAVKHRMEEMGYQDKDYDLG 354 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 + E + L D+ V DL + + + + + NI SG + A + L Sbjct 355 SLYEAFLRLADKKGQVFDYDLEALAFINLQQQEPEFFHLDNFNIQSGSNVMATAAVCLVC 414 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRIPPGGKTDALVETRITW 474 ++ E + G+G DA A+++IT P +L+ Y++ GK +AL + I Sbjct 415 GKELKSEAATGNGPVDAVYQAISRIT-----EYPIELVSYQLSGKGQGK-NALGQVNIVV 468 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F MG+ D ++ A LN + + Q+ Sbjct 469 ECF-----GRRFHGMGLETDIVESSAKAMVHALNCVWRTEQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Candidatus Blochmanniella floridana] Sequence ID: Q7VQJ6.1 Length: 519 Range 1: 7 to 507 Score:163 bits(413), Expect:3e-43, Method:Compositional matrix adjust., Identities:152/521(29%), Positives:244/521(46%), Gaps:34/521(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ+ S S EKL IA F L+KL VD +E+ S G+ E+V I + Sbjct 7 IFDTTLRDGEQSLQTSLSVKEKLQIA-FALEKLGVDVMEVGFPISSPGDFESVHTIAQNI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 + L D + + +K + +++ S H++ +L K + + Sbjct 66 QNSCVCGLARCLE-KDIDIAAEALKSAKKFRIHIFLPTSAIHIQSKLRKNFDQIIDMTTH 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 I YA K + ED R S D + +VE K I +PDT+G P + Sbjct 125 SIRYARKYTDDVEFSCEDAG---RTSIDNLCRIVEIAIKSGARTINIPDTVGYTIPNQFS 181 Query 190 QGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + + SL +K P I H H+D ++V NS+ AI+AG + + +ING+GERAGNT L Sbjct 182 EIIYSLYKKVPIIDQAIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTAL 241 Query 247 EALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 E ++ I HD + TNI+ I + S++V I AN+ IVG + F+ ++G+H Sbjct 242 EEIIMAIKIRHDLLHVYTNIHHHEIYQTSQVVSQLCNMPIPANKAIVGSNAFSHSSGIHQ 301 Query 304 DGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVI 362 DG K + P+ G K+ L +G+A++ +++++G + + ++ + + Sbjct 302 DGVLKNKKNYEIMNPKNIGLKKVQLNLTSRSGRAAVKYHMEKMGYQEHDYNIDELYKVFL 361 Query 363 ELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG---KI 419 +L DQ V +L + + + ++S +IHS +A I L Y G KI Sbjct 362 KLADQKGRVFNYELEALAFTKYSQEYLEYFALESFHIHSTSSALSNAIINL-YCGKEKKI 420 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKL----IDYEVRIPPGGKTDALVETRITWN 475 H + G G DA ALT I+ +L I + K YE I G+ + +V Sbjct 421 HSCSTTGRGPIDAAYKALTLIS-KLPIKLEKYQLHSKKYEYNIL--GQVNIIVSY----- 472 Query 476 KSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + + F +G + D A++ A + LN I Q QI Sbjct 473 ------QGRHFHGIGSNIDIIKASIIAMIQALNNIWQTKQI 507 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola str. APS (Acyrthosiphon pisum)] Sequence ID: Q9ZEY8.3 Length: 519 Range 1: 1 to 506 Score:163 bits(413), Expect:3e-43, Method:Compositional matrix adjust., Identities:142/522(27%), Positives:244/522(46%), Gaps:25/522(4%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 +++++ I D TLRDGEQ S S EKL IA L+K +D +EI S G+ ++VQ Sbjct 1 MKSKVVIFDTTLRDGEQALQASLSVKEKLQIA-LSLEKCGIDILEIGFPVSSPGDFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 I + ++ + D + + + S + +++ S H+E +L K E Sbjct 60 TISKNIKNSRICSLARCIE-KDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEI 118 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 F ++ A++ I ED + R + D + +VE L K ++ I +PDT+G Sbjct 119 IDMAVFSVKKALRYTDDIEFSCEDAT---RTTMDNLCRIVETLIKSGVKTINIPDTVGYT 175 Query 184 SPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P E + +L ++ P+IH H H+D ++V NS+ AI+AG + + +ING+GER Sbjct 176 VPNELSCIIKNLFERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGER 235 Query 241 AGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE ++ I D + TNIN I S++V I +N+ IVG + F Sbjct 236 AGNTALEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAH 295 Query 298 TAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQK 356 ++G+H DG K + P G K L +G+A++ + ++G S+ + + Sbjct 296 SSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMGYNNSDYNIDE 355 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGE-KVLTIKSCNIHSGIGIRPHAQIELEY 415 + ++L D+ V DL +A ++ + E + ++K ++ S A ++L Sbjct 356 LYTAFLKLADKKGQVFDYDLE-ALAFINKQQDEWEYFSLKFFSVQSISNSLSTASVKLLC 414 Query 416 QGKIHKEIS-EGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 K + E S +G DA AL +I P ++ + G DAL + I Sbjct 415 GKKTYTESSTTSNGPVDAIYQALNRIA-----CFPIILQKFQLVAKGKGKDALGQVDI-- 467 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 L + + F +G+ D A+ A +LN I + Q+ Sbjct 468 ---LVEHKKRKFHGVGLATDIIEASAQAMINVLNNIWKAKQV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Lactococcus lactis subsp. lactis Il1403] Sequence ID: Q02141.1 Length: 513 Range 1: 3 to 479 Score:163 bits(412), Expect:4e-43, Method:Compositional matrix adjust., Identities:151/499(30%), Positives:237/499(47%), Gaps:33/499(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++E D +LRDGEQT GVSFS SEK+ IAK L+K + +E + S E V++I Sbjct 3 KIEFFDTSLRDGEQTPGVSFSISEKVTIAK-QLEKWRISVIEAGFSAASPDSFEAVKQIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + +T + D +K V+ +K + +++ S H++ +L +P+E + Sbjct 62 DSLNDTAVTALARCV-ISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEEVLKN 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + YA + + ED + R +++ V+ I +PDT+G +PE Sbjct 121 IDKCVRYARERVEVVEFSPEDAT---RTELNFLLEAVQTAVDAGATYINIPDTVGYTTPE 177 Query 187 ETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + LI +I F H H+D ++VANSL AI+AG + ++NG+GERAGN Sbjct 178 EYGKIFKFLIDNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGN 237 Query 244 TPLEALVTTIHDK-----SNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 LE + +H + + S ++E A T + L+ FSG I N+ IVG + F Sbjct 238 AALEEIAVALHIRKDFYQAQSPLKLSETAAT--AELISQFSGIAIPKNKAIVGANAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K I PE G K S LGKL+G+ + SE + +L + + L + Sbjct 296 SGIHQDGVLKNAETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNIAYDDESLAIL 355 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPH-AQIELEYQ 416 E+ +L D+ K +T D+ + TGE V + I + I H A ++L+ Q Sbjct 356 FEKFKKLADKKKEITDADIHALF------TGETVKNLAGF-ILDNVQIDGHKALVQLKNQ 408 Query 417 -GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWN 475 +I+ EG G DA A+ K+ N KLI Y V G DA T ++ Sbjct 409 EEEIYVSQGEGSGSVDAIFKAIDKVFNHQ----LKLISYSVDAVTDG-IDAQATTLVSVE 463 Query 476 KSLDLEEDQTFKTMGVHPD 494 +L F GV D Sbjct 464 ---NLSTGTIFNAKGVDYD 479 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Synechococcus sp. RCC307] Sequence ID: A5GRZ0.1 Length: 537 Range 1: 1 to 469 Score:163 bits(413), Expect:5e-43, Method:Compositional matrix adjust., Identities:136/483(28%), Positives:214/483(44%), Gaps:40/483(8%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M + R+ I D TLRDGEQ+ G S + EKL IA+ L +L VD +E S G+ + Sbjct 1 MARDPGRVLIFDTTLRDGEQSPGASLNLDEKLAIAQ-QLARLRVDIIEAGFPFASPGDFD 59 Query 61 TVQKIMEWAATEQLTERIEILGFVDGNK------TVDWIKDSGAKVLNLLTKGSLHHLEK 114 VQ I + I G + + ++ L +H LE Sbjct 60 AVQTIARQVGR---PDGPVICGLARATRGDIKACADAVAPAANQRIHTFLATSDIH-LEH 115 Query 115 QLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERI 174 +L K+ E V ++ YA + ED R+ P+++ ++E + I Sbjct 116 KLRKSRAEVLQIVPEMVAYARSLVDDVEFSCEDAG---RSDPEFMYQVIEAAIEAGATTI 172 Query 175 FLPDTLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLH 231 +PDT+G +P E G+D+ + HGHND L+VAN L+A++ G + L Sbjct 173 NIPDTVGYSTPAEFGALIAGIDAHVPNIGQAVISVHGHNDLGLAVANFLEAVKNGARQLE 232 Query 232 ASINGLGERAGNTPLEALVTTIH--------------DKSNSKTNINEIAITEASRLVEV 277 +ING+GERAGN LE LV +H D S T I I + SRLV Sbjct 233 CTINGIGERAGNASLEELVMALHVRRSYFNGYLGRAEDSSEPLTGIQTEEIYKTSRLVSN 292 Query 278 FSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKA 336 +G + N+ IVG + F +G+H DG K L I G +LGKL+G++ Sbjct 293 LTGMAVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDARTIGLTDNRISLGKLSGRS 352 Query 337 SISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKS 396 ++ +++LG L L R EL D+ + +T DL I+ + + E + Sbjct 353 AVRARLEELGYQLDGDDLNDAFARFKELADRKREITDRDLEAIVRQ-NAQQIEAYYQLAG 411 Query 397 CNIHSGIGIRPHAQIELEYQ-GKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDY 454 + G +R A + L G+ + + G G DA AL + + +P +L+++ Sbjct 412 VQVSCGRDLRATATVTLRTSDGEECSQAAIGTGPVDAVCQALNGL-----VQVPNELVEF 466 Query 455 EVR 457 V+ Sbjct 467 SVK 469 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus haemolyticus JCSC1435] Sequence ID: Q4L7U0.1 Length: 510 Range 1: 1 to 491 Score:162 bits(411), Expect:5e-43, Method:Compositional matrix adjust., Identities:147/513(29%), Positives:244/513(47%), Gaps:36/513(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 +E+ ++I D TLRDGEQT GV+FS E+L IAK L+ VD +E S G ++VQ Sbjct 1 MESHIQIFDTTLRDGEQTPGVNFSFDERLKIAK-QLETWGVDILEAGFPASSAGSFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGK 118 I + LT + + G K+ +D + KD+ V+++ S HL +L Sbjct 60 AI-----SNTLT-KTAVCGLARCKKSDIDAVYEATKDAVKPVIHVFIATSPIHLTHKLKM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T ++ + + YA + + ED + R D++ V+ I +PD Sbjct 114 TQQQVLESIKEHVSYAKQYFDVVQFSPEDAT---RTDTDFLIKCVQMAVDCGATIINIPD 170 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E F+ + I DI + H H+D ++VANSL AI G K + ++N Sbjct 171 TVGYSYPNEYGRIFKTLIENINSKQDITYSAHCHDDLGMAVANSLAAIENGAKRIEGTVN 230 Query 236 GLGERAGNTPLEALVTTIHDKSNSKTNINEIAITE---ASRLVEVFSGKRISANRPIVGE 292 G+GERAGNT +E L ++ + + N + ++E S ++ ++G R+ N+ IVG+ Sbjct 231 GIGERAGNTAIEELALALYVRKDHYGNETRLKLSETKNTSDIISRYAGIRVPRNKAIVGQ 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSE 351 + F+ +G+H DG K + P+ G K LGKL+GK + +E +K LG + Sbjct 291 NAFSHESGIHQDGVLKNPETYEIMTPQLVGISKNDLPLGKLSGKHAFAEKLKSLGYDIEP 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE--KVLTIKSCNIHSGIGIRPHA 409 ++ ++ + D+ K VT D+ II +V T++ + + G++ Sbjct 351 QNQAELFKQFKAIADKKKSVTDRDIHAIIQGTEHEQNAIYQVDTLQLQFVSN--GLQSAV 408 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + + G I+++ S G G A NA+ +I +LIDY + G TDA E Sbjct 409 VVIKDKNGNIYQDSSIGTGSIVAIYNAVDRIFKHKS----ELIDYRIDSVTEG-TDAQAE 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHA 502 + SL + E Q +G+ D A+ A Sbjct 464 VHV----SLTI-EGQPVNGIGIDHDVLYASCKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia enterocolitica subsp. enterocolitica 8081] Sequence ID: A1JJH7.1 Length: 520 Range 1: 7 to 505 Score:162 bits(411), Expect:7e-43, Method:Compositional matrix adjust., Identities:147/527(28%), Positives:240/527(45%), Gaps:48/527(9%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+V+ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVRTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A + R+ L + VD D A+ L + +H H+E +L K Sbjct 62 AQQMKNSRVCALA-----RCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKL----K 112 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 F DV + A+ S + Y +D + R D + +VE I +P Sbjct 113 RSFDDV---LAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRIVEAAINAGATTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G +P + + L Q+ P+I H H+D +SVANS+ A++AG + + +I Sbjct 170 DTVGYTTPYQFGGIITDLYQRVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTI 229 Query 235 NGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NGLGERAGN LE ++ I + N TNIN I S+LV I AN+ IVG Sbjct 230 NGLGERAGNCSLEEVIMAIKVRENMLGVHTNINHQEIYRTSQLVSKLCNMPIPANKAIVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLS 350 + F ++G+H DG K + P+ G K L +G+A++ ++++G Sbjct 290 SNAFAHSSGIHQDGVLKNRENYEIMTPQSIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDK 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + L + + ++L D+ V DL + + + + ++ SG + A Sbjct 350 DYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHYRLDYFSVQSGSSVMATAS 409 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRIPPGGKTDALVE 469 ++L +I E + G+G DA A+ +IT+ P +L+ Y++ GK DAL + Sbjct 410 VKLVCGEEIKSEAATGNGPVDAVYQAINRITD-----YPIELVKYQLSANGQGK-DALGQ 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 I + + + F +G+ D ++ A +LN I + Q+ Sbjct 464 VDIVVD-----HKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Diuraphis noxia)] Sequence ID: O85070.1 Length: 516 Range 1: 1 to 506 Score:162 bits(411), Expect:7e-43, Method:Compositional matrix adjust., Identities:144/532(27%), Positives:242/532(45%), Gaps:45/532(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + +++ I D TLRDGEQ S S EKL IA L+K +D +E+ S G+ ++VQ Sbjct 1 MSSKVIIFDTTLRDGEQALQASLSVKEKLQIA-LSLEKCGIDIIEVGFPISSPGDFKSVQ 59 Query 64 KIMEWAATEQLT-------ERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQL 116 I + ++ + IE+ G D + D+ + +++ S H+E +L Sbjct 60 TISKKIKNSRICSLARCVEKDIEVAG--DAMSSSDFFR------IHIFLATSTLHMESKL 111 Query 117 GKTPKEFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIE 172 K E +I+ A+ S K Y +D + R + D + +VE L K ++ Sbjct 112 RKNFDE-------IIDMAVSSVKKALRYTDDVEFSCEDASRTTMDNLCRIVEKLIKAGVK 164 Query 173 RIFLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKG 229 I +PDT+G P E + +L ++ P+IH H HND ++V NS+ AI+AG + Sbjct 165 TINIPDTVGYTIPNELSNIIKNLFERVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQ 224 Query 230 LHASINGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISAN 286 + +ING+GERAGNT LE ++ I D TNI I S+++ I AN Sbjct 225 IEGTINGIGERAGNTALEEIIMAIKVREDILGVSTNIVHKEIYRTSQIISQICNMPIPAN 284 Query 287 RPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQL 345 + IVG + F ++G+H DG K + P G K L +G+A++ + ++ Sbjct 285 KAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPNTIGVKEVKLNLTSRSGRAAVKYYMDKM 344 Query 346 GMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGI 405 G + + ++ ++L D+ V DL + + + +K ++ S Sbjct 345 GYKDDDYDIDELYSAFLKLADKKGQVFDYDLEALAIFSKKQENAEYFYLKFFSVQSISNG 404 Query 406 RPHAQIELEYQGKIHKEIS-EGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKT 464 A ++L+ K++ E S +G DA AL KI N P + + G Sbjct 405 LSTASVKLKCGKKVYTESSTTSNGPVDATYQALNKIIN-----FPITLQKFQLVAKGKGK 459 Query 465 DALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 DAL + I L E++ F +G+ D ++ A +LN I + Q+ Sbjct 460 DALGQVDI-----LVKYENRQFHGIGLATDIIESSAQAMINVLNNIWKSQQV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus subtilis subsp. subtilis str. 168] Sequence ID: P94565.1 Length: 518 Range 1: 3 to 467 Score:162 bits(411), Expect:8e-43, Method:Compositional matrix adjust., Identities:135/482(28%), Positives:226/482(46%), Gaps:33/482(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ D TLRDGEQ+ GV+ +T EKL IAK L++L D +E S+G+ VQ+I Sbjct 3 KINFFDTTLRDGEQSPGVNLNTQEKLAIAK-QLERLGADIIEAGFPASSRGDFLAVQEI- 60 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 A T + + V G+ W +KD +++ S HL+ +L T ++ Sbjct 61 --ARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVI 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 +++YA K + WS + R ++ +VE + I LPDT+G Sbjct 119 ERAVGMVKYA-----KERFPIVQWSAEDACRTELPFLAEIVEKVIDAGASVINLPDTVGY 173 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 L+P E + + P+IH H H+D ++VANSL AI G + ++NG+GE Sbjct 174 LAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGE 233 Query 240 RAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE + +H + + +T I I S LV +G + N+ +VG++ F Sbjct 234 RAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFA 293 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K I PE G + LGK +G+ + + + LG + Sbjct 294 HESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQFDSEEIN 353 Query 356 KVLERVIELGDQNKLVTPEDLPFIIAD---VSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 K EL ++ K +T EDL +I + + G + L+++ +H G P A + Sbjct 354 KFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQ---VHYGTSQVPTATLS 410 Query 413 LEYQ--GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 L+ Q ++ +E + G G +A N L + ++ +L+DY ++ G+ DA + Sbjct 411 LKNQENAQLIQEAATGAGSVEAIYNTLERCIDK----DVELLDYRIQSNRKGE-DAFAQV 465 Query 471 RI 472 + Sbjct 466 YV 467 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nitrosomonas europaea ATCC 19718] Sequence ID: Q820M0.1 Length: 510 Range 1: 5 to 439 Score:162 bits(410), Expect:8e-43, Method:Compositional matrix adjust., Identities:125/441(28%), Positives:214/441(48%), Gaps:14/441(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 L I D TLRDGEQ+ G S + EK+ IA+ L+++ VD +E S+G+ E V+ + E Sbjct 5 LVIFDTTLRDGEQSPGASMTMEEKVRIAR-QLERMGVDVIEAGFPAASRGDFEAVRAVAE 63 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 + + + D ++T + ++ + ++ S H++ +L +P + Sbjct 64 AVSNSTVCGLARAME-ADIDRTGEALQVNQNVRIHTFIATSPIHMKNKLRMSPDQVIDQA 122 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 +++A + + ED R+ D++ ++E + + +PDT+G P++ Sbjct 123 IKAVKWARQYTDNVEFSPEDAG---RSEIDFLCRVLEAVIDAGARTLNIPDTVGYTMPDQ 179 Query 188 TFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 + +L ++ P+ F H HND L+VANSL A+ G + + +INGLGERAGN Sbjct 180 FGGLIRTLRERIPNSDKAIFSVHCHNDLGLAVANSLSAVMNGARQVECTINGLGERAGNA 239 Query 245 PLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 LE +V + + + T I+ I AS+LV +G + N+ IVG + F +G+ Sbjct 240 ALEEIVMAVRTRQDYFPCDTRIDTTQIVPASKLVSGITGFPVQPNKAIVGANAFAHESGI 299 Query 302 HADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL-SEVVLQKVLE 359 H DG K + E G LGK +G+ + +K+LG+ L SE L + Sbjct 300 HQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLKELGIGLESEEKLNAIFL 359 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 R +L D+ + EDL +++D + E+ + S + S G P AQ+ + G Sbjct 360 RFKDLADKKHEIFDEDLHALVSD-EAQIPEEHYRLLSLHAVSETGEIPSAQVVIAVGGSE 418 Query 420 HKEISEGDGGYDAFMNALTKI 440 + +SEG G DA A+ KI Sbjct 419 KQAVSEGSGPVDATFRAIEKI 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Proteus mirabilis HI4320] Sequence ID: B4F194.1 Length: 519 Range 1: 7 to 505 Score:162 bits(410), Expect:9e-43, Method:Compositional matrix adjust., Identities:148/526(28%), Positives:237/526(45%), Gaps:46/526(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA + L++L VD +E S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-YALERLGVDIIEAGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A E RI L + VD D A+ LN+ +H H E +L K+ Sbjct 62 AREIKNSRICALA-----RCVDNDIDVAAESLNIAEAFRIHVFLATSALHAEHKLKKS-- 114 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 F D+ IE +S + Y +D + R D + +VE I +P Sbjct 115 --FDDI---IEMGTRSIKRARRYTDDVEFSCEDAGRTHIDNLCRIVESAINAGATTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G +P + + +L ++ P+I H H+D ++VANS+ A++AG + + +I Sbjct 170 DTVGYTTPYQFGGIITNLFERVPNIDKAVISVHCHDDLGMAVANSITAVQAGARQVEGTI 229 Query 235 NGLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NGLGERAGN LE ++ I + N +T IN I S+LV I AN+ IVG Sbjct 230 NGLGERAGNCALEEVIMAIKVREQMMNVQTRINHKEIYRTSQLVSQLCNTPIHANKSIVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLS 350 + F ++G+H DG K + PE G K L +G+A++ ++++G + Sbjct 290 SNAFAHSSGIHQDGVLKNRETYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYRET 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + L + + L D+ V DL + + + N SG A Sbjct 350 DYNLDSLYAAFLRLADKKGQVFDYDLEALAFMGQQQQEPDEFVMNYFNTQSGSSTVATAS 409 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 + + + + E + G+G DA A+++ T G + KL+ Y++ G+ DAL + Sbjct 410 VSISRKNEEITEAATGNGPVDAVYQAISRAT---GYPL-KLVTYQLTAKGEGR-DALGQV 464 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 I + + F MG+ D ++ +A ++N I + Q+ Sbjct 465 DIVVEY-----QGRKFHGMGLETDIVGSSANAMMHVINSIWRSEQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus velezensis FZB42] Sequence ID: A7Z7B8.1 Length: 518 Range 1: 3 to 472 Score:162 bits(410), Expect:1e-42, Method:Compositional matrix adjust., Identities:138/487(28%), Positives:233/487(47%), Gaps:35/487(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ + D TLRDGEQ+ GV+ ++ EKL IAK L++L VD +E S+G+ VQ+I Sbjct 3 KINVFDTTLRDGEQSPGVNLNSREKLAIAK-QLERLGVDIIEAGFPASSRGDFLAVQEI- 60 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 A T + + V G+ W +KD + +++ S HL+ +L T +E Sbjct 61 --ARTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDIHLKHKLKMTREEVK 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 +++YA K + WS + R ++ +VE + I LPDT+G Sbjct 119 EKAVEMVKYA-----KERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINLPDTVGY 173 Query 183 LSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 L+P+E F+ + + + H H+D ++VANSL AI G + +ING+GE Sbjct 174 LTPDEYGNIFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECAINGIGE 233 Query 240 RAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE + +H D + +++N + S LV +G + N+ IVG++ F Sbjct 234 RAGNAALEEIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIVGDNAFA 293 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K I PE G + LGK +G+ + + + LG + Sbjct 294 HESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLNTLGFQFDSDEIN 353 Query 356 KVLERVIELGDQNKLVTPEDLPFIIAD---VSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 K EL ++ K +T +DL +I + + G + L+++ +H G P A + Sbjct 354 KYFTMFKELTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQ---VHYGTSQVPTATVS 410 Query 413 LEYQ--GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE- 469 L+ Q ++ +E + G G +A N L + ++ +L DY ++ G+ DAL + Sbjct 411 LKNQENEQLMQEAATGAGSVEAVYNTLGRCIDK----NIELTDYRIQSNRKGE-DALAQV 465 Query 470 -TRITWN 475 R+T N Sbjct 466 FVRVTVN 472 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus carnosus subsp. carnosus TM300] Sequence ID: B9DMJ6.1 Length: 510 Range 1: 2 to 490 Score:162 bits(409), Expect:1e-42, Method:Compositional matrix adjust., Identities:145/512(28%), Positives:246/512(48%), Gaps:38/512(7%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 + +++ D TLRDGEQT GVSFS E+L IAK L+K VD +E S+G ++V+ I Sbjct 2 SHIQVFDTTLRDGEQTPGVSFSFDERLTIAK-QLEKWGVDVIEAGFPASSQGSFDSVKAI 60 Query 66 MEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGKTP 120 +E LT + ++G K+ +D + KD+ L++ S HLE +L T Sbjct 61 -----SETLT-KTAVVGLARCKKSDIDAVYEATKDAKYPQLHVFIASSPIHLEHKLKMTQ 114 Query 121 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 +E +++ + Y + ED + R D++ V+ I +PDT+ Sbjct 115 EELLENITENVSYGKSLFDVVQFSPEDAT---RTDLDFLVKCVQTAVDAGASIINIPDTV 171 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G P E LI+ H + H H+D L+VANS+ AI G + ++NG+ Sbjct 172 GFSYPSEFGNIFKVLIENVKSDHEVTYSAHCHDDLGLAVANSMAAIENGATRIEGAVNGI 231 Query 238 GERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGNT LE + ++ D +TN+ S LV F+G R+ N+ IVG++ Sbjct 232 GERAGNTALEEVALGLYVRRDHYGIETNLKLDETKATSDLVASFAGIRVPRNKAIVGQNA 291 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVV 353 F+ +G+H DG K + P+ G K S LGKL+GK + +E +KQLG ++ Sbjct 292 FSHESGIHQDGFLKHPETYEIMTPQLVGIKSSELPLGKLSGKHAFAEKLKQLGYDITAEK 351 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE--KVLTIKSCNIHSGIGIRPHAQI 411 ++ ++ + D+ K V+ D+ ++ S T +V T++ + G++ + Sbjct 352 QVELFKQFKSIADKKKNVSDHDVHALVQGHSHETNAAYQVETLQLQFVSE--GVQSAVVV 409 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV-RIPPGGKTDALVET 470 +++GK + + G G A NA+ +I + +L++Y++ + G A V Sbjct 410 LKDHEGKEYPSAAIGTGSIVAVYNAVDQIFK----APSELLNYQITSVTEGSDAQAQVNV 465 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHA 502 I + +T+ +GV D +A+ A Sbjct 466 EIRIDG-------KTYYGIGVDHDVLLASCKA 490 >RecName: Full=Homocitrate synthase [Rhodobacter capsulatus] Sequence ID: Q07179.1 Length: 382 Range 1: 7 to 373 Score:159 bits(401), Expect:1e-42, Method:Compositional matrix adjust., Identities:115/380(30%), Positives:190/380(50%), Gaps:28/380(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM- 66 L + D TLRDGEQT GV+FS +EK IA+ L + V +E+ A + E+ ++ ++ Sbjct 7 LALCDTTLRDGEQTAGVAFSLAEKKAIAR-ALDRAGVAEIEVGIAAMGWAEVAEIRAVVA 65 Query 67 EWA-ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 E A AT + R+ + +D + +G K ++ S LE +L Sbjct 66 EIAHATPVVWCRLRM-------HDLDMAQKTGVKRVHFAVPTSTAQLEGKLRVDRDWILR 118 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 + + ++ A GL+++V ED S R PD++ L E + R + DTLG+L P Sbjct 119 ETAALVFCASDRGLQVSVGAEDAS---RTDPDFLIRLAEVAAAAGAIRFRIADTLGLLDP 175 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 F+ V L + + E H HND+ ++ AN++ A AG L ++NGLGERAGN Sbjct 176 LGAFRLVAELSARI-SLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGNAA 234 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED-VFTQTAGVHAD 304 E + + + T ++ A+ E S +V SG+ A +PI G+D +F +G+H D Sbjct 235 CEEVGAAL-EAGGIDTGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLFAHESGIHVD 293 Query 305 GD-KKGNLYANP-ILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV----- 357 K+ + Y +P P RFGR+R +GK +G A + + + G+ + VL ++ Sbjct 294 AILKRADTYEDPRCAPARFGRERQIVIGKHSGSAGLRAALLEAGLPADDAVLDRLKPLLR 353 Query 358 -----LERVIELGDQNKLVT 372 ++R +E GD ++V Sbjct 354 AHAVRVKRPVEAGDLRRMVA 373 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Geobacillus thermodenitrificans NG80-2] Sequence ID: A4IRH8.1 Length: 515 Range 1: 3 to 463 Score:162 bits(409), Expect:1e-42, Method:Compositional matrix adjust., Identities:141/475(30%), Positives:226/475(47%), Gaps:26/475(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +++ D TLRDGEQ+ GV+ + EKL IA+ L++L VD +E SKG+ E V++I Sbjct 3 KIKFFDTTLRDGEQSAGVNLNLQEKLEIAR-QLERLQVDIIEAGFPASSKGDFEAVKQIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 E T +T + V + W +K L+L S H+ +L TP++ Sbjct 62 ETVRTCSVTG---LSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVI 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 ++YA K + WS + R+ ++ +V + K I +PDT+G Sbjct 119 EAAVEAVKYA-----KRFFPIVQWSAEDACRSELPFLAKIVTEVIKAGASVINIPDTVGY 173 Query 183 LSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 ++P+E F + + + +I H H+D ++V NSL AI G + +ING+GE Sbjct 174 ITPKEYGEIFLYLRNNVPNIENISLSAHCHDDLGMAVINSLSAIEHGATQVECTINGIGE 233 Query 240 RAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE + +H D +T +N I S LV +G + N+ +VG++ F Sbjct 234 RAGNAALEEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGMVVPPNKAVVGKNAFA 293 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K I PE G S LGK +G+ ++ V++LG LSE + Sbjct 294 HESGIHQDGVLKEKTTYEIISPELVGVSSNSMVLGKHSGRHALRNRVEELGYTLSEEEIN 353 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-E 414 ++ R EL D+ K VT +DL +I + + + S + G P A + L + Sbjct 354 QLFVRFKELADKKKDVTDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKD 413 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 +G +E + G G +A N L R + L+DY + GG+ DAL + Sbjct 414 GKGNTIQEAATGAGSVEALYNTL----ERCFQTAVTLLDYRIESVGGGR-DALAQ 463 >RecName: Full=Methylthioalkylmalate synthase 3, chloroplastic; AltName: Full=2-isopropylmalate synthase 2; AltName: Full=Methylthioalkylmalate synthase-like; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q9FN52.1 Length: 503 Range 1: 85 to 485 Score:161 bits(408), Expect:2e-42, Method:Compositional matrix adjust., Identities:120/405(30%), Positives:201/405(49%), Gaps:25/405(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + +LD TLRDGEQ+ G + + +KL IA+ L KL VD +E+ S+ E E ++ I + Sbjct 85 VRVLDTTLRDGEQSPGAALTPPQKLEIAR-QLAKLRVDIMEVGFPVSSEEEFEAIKTIAK 143 Query 68 WAATE--QLTERIEILGFVDGNKTVD----W--IKDSGAKVLNLLTKGSLHHLEKQLGKT 119 E + T + ++ + K D W +K + + L T S H++ +L KT Sbjct 144 TVGNEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSEIHMKYKLKKT 203 Query 120 PKEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 +E ++YA G K I ED G R D++ ++ K + D Sbjct 204 KEEVIEMAVNSVKYAKSLGFKDIQFGCED---GGRTEKDFICKILGESIKAGATTVGFAD 260 Query 179 TLGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G+ P+E + V +I+ P DI F H HND ++ AN++ I AG + + +IN Sbjct 261 TVGINMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGARQVEVTIN 320 Query 236 GLGERAGNTPLEALVTTIHDKSNS-----KTNINEIAITEASRLVEVFSGKRISANRPIV 290 G+GER+GN PLE +V + + S T I+ I S++V+ +G + ++PIV Sbjct 321 GIGERSGNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYVQPHKPIV 380 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLG 346 G++ F +G+H DG K + PE G +S LGKL+G+ ++ + +K+LG Sbjct 381 GDNCFVHESGIHQDGILKNRSTYEILSPEDVGIVKSENSGIVLGKLSGRHAVKDRLKELG 440 Query 347 MVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKV 391 +S+ + R EL K +T DL ++ + + + EK+ Sbjct 441 YEISDEKFNDIFSRYRELTKDKKRITDADLKALVVNGAEISSEKL 485 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pectobacterium atrosepticum SCRI1043] Sequence ID: Q6D0G8.1 Length: 532 Range 1: 7 to 505 Score:162 bits(409), Expect:2e-42, Method:Compositional matrix adjust., Identities:145/518(28%), Positives:238/518(45%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA F L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-FALERMGVDVMEVGFPVSSPGDFESVQTIARNI 65 Query 70 ATEQ---LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + LT +E D + + ++ + A ++ S H+ +L T E Sbjct 66 KNSRVCGLTRCVE----KDIDVAAEALRVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++I+ A + ED G PD + +VE I +PDT+G P Sbjct 122 AIYMIKRARNYTDDVEFSCEDA--GRTPIPDLCR-VVEAAINAGARTINIPDTVGYTMPH 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + SL Q P+I H H+D L+V N++ A+ AG + + ++NG+GERAGN Sbjct 179 EFGNIIASLYQHVPNIDKAIISVHTHDDLGLAVGNAMAAVHAGARQVEGTLNGIGERAGN 238 Query 244 TPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE ++ I HD N TNIN I S+LV I AN+ +VG + F ++G Sbjct 239 CSLEEVIMAIKTRHDILNVHTNINHQEIYRTSQLVSQICNMPIPANKAVVGANAFAHSSG 298 Query 301 VHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + PE G K L +G+A++ ++++G ++ L + Sbjct 299 IHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDNDYNLDDLYS 358 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGE-KVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 ++L D+ V DL +A +S + E + + ++ SG + A ++L + Sbjct 359 AFLKLADKKGQVFDYDLE-ALAFISRQQEEPEFYHLDYFSVQSGSSVMATASVKLICGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 E + G+G DA A+ +IT G + L+ Y++ G+ DAL + I + Sbjct 418 TQSEAATGNGPVDAVYQAINRIT---GYQV-SLVKYQLTAKGQGR-DALGQVDIVADY-- 470 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + + F +G+ D ++ A +LN I + Q+ Sbjct 471 ---QGRRFHGVGLATDIVESSAQAMVNVLNNIKRAQQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Geobacillus stearothermophilus] Sequence ID: Q8RL85.1 Length: 515 Range 1: 4 to 463 Score:161 bits(408), Expect:2e-42, Method:Compositional matrix adjust., Identities:140/474(30%), Positives:226/474(47%), Gaps:26/474(5%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 ++ D TLRDGEQ+ GV+ + EKL IA+ L++L VD +E SKG+ E V++I E Sbjct 4 IKFFDTTLRDGEQSAGVNLNLQEKLEIAR-QLERLRVDIIEAGFPASSKGDFEAVKQIAE 62 Query 68 WAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 T +T + V + W +K L+L S H+ +L TP++ Sbjct 63 TVRTCSVTG---LSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVIE 119 Query 126 DVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 ++YA K + WS + R+ ++ +V + K I +PDT+G + Sbjct 120 AAVEAVKYA-----KRFFPIVQWSAEDACRSELPFLAKIVAEVIKAGASVINIPDTVGYI 174 Query 184 SPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +P+E F + + +Q ++ H H+D ++V NSL AI G + +ING+GER Sbjct 175 TPKEYGEIFLYLQNNVQNIENVSLSAHCHDDLGMAVVNSLSAIEHGATQVECTINGIGER 234 Query 241 AGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGN LE + +H D +T +N I S LV +G + N+ +VG++ F Sbjct 235 AGNAALEEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGVVVPPNKAVVGKNAFAH 294 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K I PE G S LGK +G+ ++ V++LG LS+ + + Sbjct 295 ESGIHQDGVLKEKTTYEIISPELVGVPSNSMVLGKNSGRHALRYRVEELGYTLSDEEINQ 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY- 415 + R EL D+ K +T +DL +I + + + S + G P A + L+Y Sbjct 355 LFVRFKELADKKKDITDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKYG 414 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 +G +E + G G A N L R + L+DY + GG+ DAL + Sbjct 415 KGNEIQEAATGSGSVYALYNTL----ERCFQTEVTLLDYRIESVGGGR-DALAQ 463 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella oneidensis MR-1] Sequence ID: Q8E9N2.1 Length: 522 Range 1: 1 to 498 Score:161 bits(408), Expect:2e-42, Method:Compositional matrix adjust., Identities:144/526(27%), Positives:242/526(46%), Gaps:49/526(9%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ ++ ++YA + + ED R D + +VE I Sbjct 111 LKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAIHAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGSIIQTLFNRVPNIDQAIISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + + + N +T IN I S LV I +N+ I Sbjct 228 TMNGIGERAGNCSLEEIAMILATRKNLLGFETGINAKEIHRTSNLVSQLCNMPIQSNKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE------KVLTIKSCNIHSG 402 + L + E+ + L D+ V DL +A + + E + L ++S + G Sbjct 348 SQDYNLDALYEQFLHLADKKGQVFDYDLE-ALAFIEAQAAEDNFYQLRQLVVQS-DSTEG 405 Query 403 IGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGG 462 + A + +E G+I E + G+G DA NA+ + T+R +I Y++ G Sbjct 406 VAT---ATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGVG 458 Query 463 KTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 + DAL + IT + +Q F +G+ D A+ A ++N Sbjct 459 Q-DALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Sodalis glossinidius str. 'morsitans'] Sequence ID: Q2NVW3.1 Length: 525 Range 1: 7 to 505 Score:161 bits(408), Expect:2e-42, Method:Compositional matrix adjust., Identities:142/526(27%), Positives:241/526(45%), Gaps:46/526(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL +A+ L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQVAQ-ALERMGVDVMEVGFPVSSPGDFESVQTIARQI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 + + G + VD D A+ L + +H H+E +L K+ Sbjct 66 KNSR------VCGLA---RCVDRDIDVAAEALRVAEAFRIHLFLATSTLHVESKLKKSFD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + V+E A+ S + Y +D + R D + +VE K I +P Sbjct 117 Q-------VVEMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRIVEATIKAGARTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G +P + + SL Q P+I H H+D ++V NS+ AI++G + + ++ Sbjct 170 DTVGYTTPNQFGGIISSLYQHVPNIDKAIISVHCHDDLGMAVGNSIAAIQSGARQVEGTL 229 Query 235 NGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGNT LE ++ I D N T I+ I S++V I AN+ +VG Sbjct 230 NGIGERAGNTALEEVIMAIKVRQDLLNVHTGIHHQEIYRTSQVVSQLCNMPIPANKAVVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLS 350 + F ++G+H DG K + PE G K L +G+A++ ++++G S Sbjct 290 ANAFAHSSGIHQDGVLKNRQNYEIMTPEIIGLKEVQLNLTSRSGRAAVKHRMQEMGYQES 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 L ++ + ++L D+ V DL + + + + ++ ++ S A Sbjct 350 NYSLDELYDAFLKLADKKGQVFDYDLEALAFINNQQEQSEHFRLEYFSVQSSSADIATAS 409 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 ++L + ++H E + G+G DA AL +IT +L I + K Y++ G+ DAL + Sbjct 410 VKLAFGDEVHAEAATGNGPVDAVYEALNRIT-QLPIQLEK---YQLTAKGHGR-DALGQV 464 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 I E + F +G+ D ++ A +N I + Q+ Sbjct 465 DIVVEY-----EGRRFHGVGLATDIIESSALAMVNSMNTIWRARQV 505 >RecName: Full=Homocitrate synthase; Short=HCS [Sulfolobus acidocaldarius DSM 639] Sequence ID: Q4J989.1 Length: 468 Range 1: 6 to 358 Score:160 bits(404), Expect:2e-42, Method:Compositional matrix adjust., Identities:108/364(30%), Positives:183/364(50%), Gaps:16/364(4%) Query 3 KVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV 62 K+ ++ ILD TLR+GEQT GV F+T +++ IAK L + V +E VS E + Sbjct 6 KLHMKVGILDSTLREGEQTPGVVFTTDQRVEIAK-ALSDIGVQMIEAGHPAVSPDIYEGI 64 Query 63 QKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKV----LNLLTKGSLHHLEKQLGK 118 ++I++ + I V ++ V + GA++ + + S HL+ + Sbjct 65 RRIIKLKREGVIKSEI-----VAHSRAVKRDIEVGAEIEADRIAIFYGISDTHLKAKHHT 119 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T E ++ + YA G+K+ ED + R Y+ +++ + +R+ + D Sbjct 120 TRDEALRSIAETVSYAKSHGVKVRFTAEDAT---RADYQYLLEVIKTVRDAGADRVSIAD 176 Query 179 TLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 T+GVL P T + L ++PDI F+ H HND ++VAN L A G +H ++NGLG Sbjct 177 TVGVLYPSRTRELFKDLTSRFPDIEFDIHAHNDLGMAVANVLAAAEGGATIIHTTLNGLG 236 Query 239 ERAGNTPLEALVTTIHDKSNSKTNINEI-AITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 ER G PL+ + + K + + ++ ++E + LVE +SG + N PI G+ F Sbjct 237 ERVGIAPLQVVAAAL--KYHFGIEVVDLKKLSEVASLVEKYSGIALPPNFPITGDYAFVH 294 Query 298 TAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 AGVH G + PE FGR R Y + K GK ++ + +LG+ L++ + +V Sbjct 295 KAGVHVAGVLNDPKTYEFLPPETFGRSRDYVIDKYTGKHAVKDRFDRLGVKLTDSEIDQV 354 Query 358 LERV 361 L ++ Sbjct 355 LAKI 358 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Candidatus Endomicrobiellum trichonymphae] Sequence ID: B1H0A7.1 Length: 516 Range 1: 8 to 470 Score:161 bits(407), Expect:3e-42, Method:Compositional matrix adjust., Identities:141/479(29%), Positives:223/479(46%), Gaps:35/479(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 D TLRDGEQ+ G S + EKL +A L L VD +E S+G+ E V+ I + Sbjct 8 FFDTTLRDGEQSPGASMNLKEKLLVAN-QLAALGVDVIEAGFPISSQGDFEAVKTISQQI 66 Query 70 ATEQLTERIEILGFVDGNK---TVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 T I G ++ T W +K + +++ S H+EK+L KT + Sbjct 67 KTSS------IAGLCRASEKDITTCWNAVKYAKKPRIHIFLATSDLHIEKKLQKTRAQIL 120 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 I+Y + ED R+ D++ +VE + + +PDT+G + Sbjct 121 DMAVKTIKYGKSLCKDVEFSAEDAG---RSDMDFLCKVVEAVIDAGATTVNIPDTVGYTT 177 Query 185 PEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 P E + + ++ P+++ H HND L+VANSL AI G + + +ING+GERA Sbjct 178 PIEFGNKIAEIKRRVPNVNKAIISVHCHNDLGLAVANSLSAIENGARQIECTINGIGERA 237 Query 242 GNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GNT LE + T+ H N K + + S+LV +G + N+ +VG + F Sbjct 238 GNTSLEEIAMTLKVRHHYYNVKHTLKTNELYNTSKLVSRLTGILVQVNKAVVGANAFAHE 297 Query 299 AGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K + P G S LGK +G+ + + +K LG L E L+ + Sbjct 298 SGIHQDGVLKARETYEIMSPADVGVPESLLVLGKHSGRHAFFKRIKDLGYKLDEKTLEHL 357 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ- 416 E+ L D+ K V +D+ +I + + +G++ + + SG G P A +++ Sbjct 358 FEKFKILADKKKTVFDDDIIALIEEDTS-SGKETFILNYLSATSGTGTIPTATVKISKSE 416 Query 417 -GKIHKEI-----SEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 K K I + G G DA A+ KI N + I KL D+ +R G+ DAL E Sbjct 417 GNKKTKSITLQAAACGSGPVDATYKAIDKIIN-MDI---KLTDFSLRSVSSGE-DALGE 470 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pasteurella multocida subsp. multocida str. Pm70] Sequence ID: Q9CJN5.1 Length: 518 Range 1: 7 to 507 Score:161 bits(407), Expect:3e-42, Method:Compositional matrix adjust., Identities:147/528(28%), Positives:243/528(46%), Gaps:48/528(9%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA F L++L VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALKASLTVKEKLQIA-FALERLGVDVMEVGFPISSAGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A R+ L ++ VD D+ A+ L + +H H+E +L +T Sbjct 62 ARHIKHSRVCAL-----SRAVDKDIDAAAEALKVAEAFRIHTFIATSALHVEAKLRRT-- 114 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 F DV ++ AI + + Y +D + R D + +VE K + +P Sbjct 115 --FEDV---VDMAINAVKRARNYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G P + + +++ + P+I H HND ++ ANSL A++ G + + +I Sbjct 170 DTVGYCLPYQYGDIIANVMNRVPNIDKAIISVHCHNDLGMATANSLTAVQNGARQIECTI 229 Query 235 NGLGERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIV 290 NG+GERAGNT LE +V I + + T IN I S++V I N+ IV Sbjct 230 NGIGERAGNTALEEVVMAIKTRQDMFNGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIV 289 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVL 349 G + F ++G+H DG K + PE G +K L +G+A++ ++ ++G Sbjct 290 GSNAFAHSSGIHQDGMVKHKNTYEIMSPESIGLKKEKLNLTARSGRAAVKNHMSEMGYQE 349 Query 350 SEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 S+ L K+ E ++L D+ V DL + + E LT+ + A Sbjct 350 SDYDLDKLYEAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLTLDVITSQCISHLPASA 409 Query 410 QIELEYQGKIHKEISE-GDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALV 468 +++E GK ++S G+G DA NA+ IT G+ + K+++Y + G +AL Sbjct 410 FVQVELDGKKMSQVSNGGNGPVDAVYNAILAIT---GLEM-KMLNYNL-TAKGEGAEALG 464 Query 469 ETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + I E + F +G+ D ++ A +N I + ++ Sbjct 465 QVDIVVE-----HEGRRFHGVGLATDIVESSARALIHAINAIYRSQKV 507 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pectobacterium carotovorum subsp. carotovorum PC1] Sequence ID: C6DEV8.1 Length: 532 Range 1: 7 to 505 Score:161 bits(407), Expect:3e-42, Method:Compositional matrix adjust., Identities:142/517(27%), Positives:234/517(45%), Gaps:28/517(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA F L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-FALERMGVDVMEVGFPVSSPGDFESVQTIARNI 65 Query 70 ATEQ---LTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + LT +E D + + ++ + A ++ S H+ +L T E Sbjct 66 KNSRVCGLTRCVE----KDIDVAAEALRVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++I+ A + ED G PD + +VE I +PDT+G P Sbjct 122 AIYMIKRARNYTDDVEFSCEDA--GRTPIPDLCR-VVEAAINAGARTINIPDTVGYTMPH 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + SL Q P+I H H+D L+V N++ A+ AG + + ++NG+GERAGN Sbjct 179 EFGNIISSLYQHVPNIDKAIISVHTHDDLGLAVGNAMAAVHAGARQVEGTLNGIGERAGN 238 Query 244 TPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE ++ I H+ N TNIN I S+LV I AN+ +VG + F ++G Sbjct 239 CSLEEVIMAIKTRHNILNVHTNINHQEIYRTSQLVSQICNMPIPANKAVVGANAFAHSSG 298 Query 301 VHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + PE G K L +G+A++ ++++G S+ L + Sbjct 299 IHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDSDYNLDDLYS 358 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 ++L D+ V DL + + + + ++ SG + A ++L + Sbjct 359 AFLKLADKKGQVFDYDLEALAFINRQQEEPEFYHLDYFSVQSGSSVMATASVKLICGEET 418 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLD 479 E + G+G DA A+ +IT G + L+ Y++ G+ DAL + I + Sbjct 419 QSEAATGNGPVDAVYQAINRIT---GYQV-SLVKYQLTAKGQGR-DALGQVDIVADY--- 470 Query 480 LEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + + F +G+ D ++ A +LN I + Q+ Sbjct 471 --QGRRFHGVGLATDIVESSAQAMVNVLNNIKRAQQV 505 >RecName: Full=2-isopropylmalate synthase 1; AltName: Full=Alpha-IPM synthase 1; AltName: Full=Alpha-isopropylmalate synthase 1 [Caldanaerobacter subterraneus subsp. tengcongensis MB4] Sequence ID: Q8RDK3.1 Length: 397 Range 1: 5 to 380 Score:158 bits(399), Expect:3e-42, Method:Compositional matrix adjust., Identities:116/384(30%), Positives:190/384(49%), Gaps:18/384(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ + D TLRDGEQT GV+F++ +KL IA + L KL VD +E S G+ E V+ I Sbjct 5 RVIVFDTTLRDGEQTPGVNFNSRDKLEIA-YQLAKLGVDVIEAGFPAASNGDFEAVKNIA 63 Query 67 EWAATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ + +T I +G D ++ +K++ L++ S HL+ +L T E Sbjct 64 DY--VKGVT--IAAMGRAVKEDIDRASSALKNAEKSRLHVFIATSDIHLQYKLKMTRDEV 119 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 +++YA +I ED S R D++ + + I +PDT+G Sbjct 120 LKKAVEMVKYARGKFDEIEFSAEDAS---RTDWDFLVKVFSEVIDAGAHIINVPDTVGYA 176 Query 184 SPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P E + + + P+I H HND L+VANSL AI G + ++NG+GER Sbjct 177 MPREYGELIRYIRNNVPNIDGVTISAHCHNDLGLAVANSLSAIENGATQVEVTVNGIGER 236 Query 241 AGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGN +E ++ ++ + + IN I S+LV +G ++ N+ IVG + F Sbjct 237 AGNAAMEEVIMALNTRKDYFGLVHGINTKEIYNTSKLVSELTGIKLQPNKAIVGANAFRH 296 Query 298 TAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H G L + PE G ++ALGKL+G+ + V+QLG LS + + Sbjct 297 QSGIHQHGVINNRLTYEIMRPEDIGVVPDTFALGKLSGRNAFELKVRQLGYNLSPGEISE 356 Query 357 VLERVIELGDQNKLVTPEDLPFII 380 + +L D+ K + ED+ F++ Sbjct 357 AFRKFKDLADRKKTIVEEDIRFVV 380 >RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus islandicus L.S.2.15] Sequence ID: C3MPM7.1 Length: 461 Range 1: 3 to 436 Score:159 bits(403), Expect:3e-42, Method:Compositional matrix adjust., Identities:129/449(29%), Positives:220/449(48%), Gaps:26/449(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ ILD TLR+GEQT GV F+ +++ IAK L L V +E VS E +++I+ Sbjct 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAK-ALSDLGVSMIEAGHPAVSPDIYEGIKRIV 61 Query 67 EWAATEQLTERIEILGFVDG-NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 + +T EI+G + ++ + + + S HL+ + T +E Sbjct 62 KLKKEGIITS--EIVGHSRAVKRDIEIAAELEVNRIAIFYGVSDLHLKAKHKATREEALR 119 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 ++ I YA G+K+ ED G R D++ ++ + +R+ + DT+G+L P Sbjct 120 TIAETISYAKNHGVKVRFTAED---GSRTDFDFLVTVSKTARDAGADRVSIADTVGILYP 176 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 +T + +L ++ P++ F+ H HND L+VAN+L AI G +HA++NGLGER G P Sbjct 177 SKTKELFSALTREVPNLEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERVGIVP 236 Query 246 LEALVTTIHDKSNSKTNINEI-AITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 L+ + I K + + ++ + S LVE +SG + N PI G+ F AGVH Sbjct 237 LQQIAAAI--KYHFGIEVVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGVHVA 294 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 G + PE FGR R Y + K GK ++ + ++LG+ +S+ + ++L + I+ Sbjct 295 GVLNDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAK-IKS 353 Query 365 GDQNKLVTPEDLPFIIADVSGRTG--------EKVLTIKS-CNIHSGIGIRPHAQIELEY 415 + DL + +V+GR E ++++K N+++ R + I Sbjct 354 NTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEALISVKCDSNVYTTSVTRRLSVI---- 409 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRL 444 G KE+ E G YD + K +N L Sbjct 410 NGV--KEVMEISGDYDILVKVQAKDSNEL 436 >RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus islandicus M.14.25] Sequence ID: C3MYM1.1 Length: 461 >RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus islandicus M.16.27] Sequence ID: C3N5A3.1 Length: 461 >RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus islandicus Y.G.57.14] Sequence ID: C3NDV7.1 Length: 461 >RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus islandicus Y.N.15.51] Sequence ID: C3NHU6.1 Length: 461 >RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus islandicus M.16.4] Sequence ID: C4KGW9.1 Length: 461 Range 1: 3 to 436 Score:159 bits(403), Expect:3e-42, Method:Compositional matrix adjust., Identities:129/449(29%), Positives:220/449(48%), Gaps:26/449(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ ILD TLR+GEQT GV F+ +++ IAK L L V +E VS E +++I+ Sbjct 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAK-ALSDLGVSMIEAGHPAVSPDIYEGIKRIV 61 Query 67 EWAATEQLTERIEILGFVDG-NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 + +T EI+G + ++ + + + S HL+ + T +E Sbjct 62 KLKKEGIITS--EIVGHSRAVKRDIEIAAELEVDRIAIFYGVSDLHLKAKHKATREEALR 119 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 ++ I YA G+K+ ED G R D++ ++ + +R+ + DT+G+L P Sbjct 120 TIAETISYAKNHGVKVRFTAED---GSRTDFDFLVTVSKTARDAGADRVSIADTVGILYP 176 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 +T + +L ++ P++ F+ H HND L+VAN+L AI G +HA++NGLGER G P Sbjct 177 SKTKELFSALTREVPNLEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERVGIVP 236 Query 246 LEALVTTIHDKSNSKTNINEI-AITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 L+ + I K + + ++ + S LVE +SG + N PI G+ F AGVH Sbjct 237 LQQIAAAI--KYHFGIEVVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGVHVA 294 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 G + PE FGR R Y + K GK ++ + ++LG+ +S+ + ++L + I+ Sbjct 295 GVLNDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAK-IKS 353 Query 365 GDQNKLVTPEDLPFIIADVSGRTG--------EKVLTIKS-CNIHSGIGIRPHAQIELEY 415 + DL + +V+GR E ++++K N+++ R + I Sbjct 354 NTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEALISVKCDSNVYTTSVTRRLSVI---- 409 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRL 444 G KE+ E G YD + K +N L Sbjct 410 NGV--KEVMEISGDYDILVKVQAKDSNEL 436 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus cytotoxicus NVH 391-98] Sequence ID: A7GMU1.1 Length: 506 Range 1: 6 to 465 Score:160 bits(405), Expect:4e-42, Method:Compositional matrix adjust., Identities:137/482(28%), Positives:226/482(46%), Gaps:41/482(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEW- 68 +D TLRDGEQ+ GV+ + EKL IA+ L+KL +D +E A S+G+ ++V++I E Sbjct 6 FMDTTLRDGEQSPGVNLNEQEKLQIAR-QLEKLGIDVMEAGFAAASEGDFQSVKRIAESI 64 Query 69 --AATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A+ L E D K + +K + + L++ S H++ +L + ++ Sbjct 65 QNASVMSLARAKE----SDIRKAYEAVKRAVSPRLHVFLATSDIHMKYKLCMSKEDVLDS 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + + ED + R + ++ VE + + I +PDT+G PE Sbjct 121 IHRSVILGKSLFPTVQFSAEDAT---RTAQPFLAEAVEVAIRAGADVINIPDTVGYTHPE 177 Query 187 E---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E FQ + + Y F H H+D ++VANSL AI G + +ING+GERAGN Sbjct 178 EYYSLFQYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAIEGGALQVEGTINGIGERAGN 237 Query 244 TPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE + +H D ++++I I S LV +G I N+ IVG + F +G Sbjct 238 AALEEVAVALHIRKDHYKTQSSIILKEIKATSTLVSRLTGMMIPKNKAIVGANAFAHESG 297 Query 301 VHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K I PE G ++ + LGK +G+ + +E +K+LG L++ E Sbjct 298 IHQDGVLKEVTTYEIIAPELIGESQNLFVLGKHSGRHAFTERMKELGYELTQKERDAAFE 357 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVL-----TIKSCNIHSGIGIRPHAQIEL- 413 L D+ K +T EDL ++ GE L IK +H + H Q Sbjct 358 AFKALADRKKEITDEDLRALM------LGEAALLTQQYNIKQLQVHF---VSNHIQCATV 408 Query 414 ---EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 + +G +++ + G G +A +A+ +I KL+DY ++ G+ DAL Sbjct 409 VLQDGKGNKYEDAATGAGSIEAIYHAIQRILEME----CKLVDYRIQSITQGQ-DALAHV 463 Query 471 RI 472 + Sbjct 464 HV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pestis Pestoides F] Sequence ID: A4TQA2.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pseudotuberculosis IP 31758] Sequence ID: A7FM84.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pestis Angola] Sequence ID: A9R142.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pseudotuberculosis YPIII] Sequence ID: B1JK98.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pseudotuberculosis PB1/+] Sequence ID: B2K4C9.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pestis Antiqua] Sequence ID: Q1C1Z6.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pestis Nepal516] Sequence ID: Q1CMP5.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pseudotuberculosis IP 32953] Sequence ID: Q66EM1.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Yersinia pestis] Sequence ID: Q8ZIG8.1 Length: 520 Range 1: 7 to 505 Score:160 bits(405), Expect:5e-42, Method:Compositional matrix adjust., Identities:146/527(28%), Positives:239/527(45%), Gaps:48/527(9%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+V+ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDIMEVGFPVSSPGDFESVRTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A + R+ L + VD D A+ L + +H H+E +L K Sbjct 62 AQQVKNSRVCALA-----RCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKL----K 112 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 F DV + A+ S + Y +D + R D + +VE I +P Sbjct 113 RSFDDV---LAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G +P + + L ++ P+I H H+D +SVANS+ A++AG + + +I Sbjct 170 DTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTI 229 Query 235 NGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NGLGERAGN LE ++ I H+ TNIN I S+LV I N+ IVG Sbjct 230 NGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLS 350 + F ++G+H DG K + PE G K L +G+A++ ++++G Sbjct 290 SNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDK 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + L + + ++L D+ V DL + + + + ++ SG + A Sbjct 350 DYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATAS 409 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRIPPGGKTDALVE 469 ++L +I E + G+G DA A+ +IT+ P +L+ Y++ GK DAL + Sbjct 410 VKLVCGEEIKSEAATGNGPVDAVYQAINRITD-----YPIELVKYQLSAKGQGK-DALGQ 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 I + + + F +G+ D ++ A +LN I + Q+ Sbjct 464 VDIVVD-----HKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus licheniformis DSM 13 = ATCC 14580] Sequence ID: Q65GI8.1 Length: 518 Range 1: 3 to 467 Score:159 bits(403), Expect:8e-42, Method:Compositional matrix adjust., Identities:138/483(29%), Positives:229/483(47%), Gaps:35/483(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ D TLRDGEQ+ GV+ +T EKL IA+ L+KL V+ +E S G+ V++I Sbjct 3 KINFFDTTLRDGEQSPGVNLNTQEKLAIAQ-QLEKLGVNIMEAGFPASSPGDFNAVKEI- 60 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 A T + + V G+ W +KD L++ S HL+ +L KT ++ Sbjct 61 --ARTIKNCSVTGLARSVKGDIDSAWEALKDGAEPRLHIFIATSDIHLKYKLKKTREQVL 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 +++YA K + WS + R ++ +V + + + LPDT+G Sbjct 119 EQAVAMVKYA-----KERFPIVQWSAEDACRTDLPFLAEIVSEVIAAGADVVNLPDTVGY 173 Query 183 LSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 L+P E F+ + + + H H+D ++VANSL AI G + + ING+GE Sbjct 174 LAPAEYGNIFRYIKENARNADKVQLSAHCHDDLGMAVANSLAAIENGADQVESVINGIGE 233 Query 240 RAGNTPLEALVTTIHDKSN-----SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 RAGN LE + +H + + S +NEI T S LV +G + N+ +VG++ Sbjct 234 RAGNASLEEIAVALHIRKDFYQAESTIQLNEIKRT--SDLVSKLTGMAVPRNKAVVGDNA 291 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVV 353 F +G+H DG K I PE G K + LGK +G+ + + ++ LG L E Sbjct 292 FAHESGIHQDGFLKEKTTYEIISPELVGVKTDALVLGKHSGRHAFKDKLQNLGFQLGEEE 351 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIK--SCNIHSGIGIRPHAQI 411 + K EL + K T EDL +I + +T ++ + S +H G P A + Sbjct 352 INKFFNIFKELTGKKKEFTDEDLISLI--LEEKTADRKIGYDFISLQVHYGTSQVPTATV 409 Query 412 ELEYQ--GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 L+ Q ++ +E + G G +A N L + ++ +L+DY ++ G+ DA + Sbjct 410 SLKDQETDQVIQEAATGAGSVEAVYNTLKRCMDKE----VQLLDYRIQSNRKGQ-DAFAQ 464 Query 470 TRI 472 + Sbjct 465 VYV 467 >RecName: Full=Methylthioalkylmalate synthase 2, chloroplastic; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q8VX04.1 Length: 506 Range 1: 82 to 484 Score:159 bits(401), Expect:1e-41, Method:Compositional matrix adjust., Identities:123/407(30%), Positives:200/407(49%), Gaps:25/407(6%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 E + + D TLRDGEQ G S + +KL IA+ L KL VD +E+ S+ ELETV+ Sbjct 82 ENYVRVFDTTLRDGEQAPGGSLTPPQKLEIAR-QLAKLRVDIMEVGFPGSSEEELETVKT 140 Query 65 IMEWAATE--QLTERIEILGFVDGNKTVD----W--IKDSGAKVLNLLTKGSLHHLEKQL 116 I + E + T + ++ + +K D W +K + + + T S H++ +L Sbjct 141 IAKTVGNEVDEETGYVPVICAIARSKHRDIEAAWEAVKYAKRPRILIFTSTSDIHMKYKL 200 Query 117 GKTPKEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 KT +E I +A G I + ED G R+ D++ ++ K + + Sbjct 201 KKTQEEVIEMAVSSIRFAKSLGFNDIQLGCED---GGRSDKDFLCKILGEAIKADVTVVN 257 Query 176 LPDTLGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 + DT+G+ P E + V L P D+ F H HND L+ ANS+ IRAG + + Sbjct 258 VADTVGINMPHEYAELVTYLKANTPGIDDVVFSVHCHNDLGLATANSIAGIRAGARQVEV 317 Query 233 SINGLGERAGNTPLEALVTTIHDK-----SNSKTNINEIAITEASRLVEVFSGKRISANR 287 +ING+GER+GN LE +V + + + T I+ I S++V+ ++G + A++ Sbjct 318 TINGIGERSGNASLEEVVMALKCRGAYVINGVYTRIDTRQIMATSKMVQEYTGLYVQAHK 377 Query 288 PIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVK 343 PIVG + F +G+H DG K + PE G +S LGKL+G+ ++ + +K Sbjct 378 PIVGANCFVHESGIHQDGILKNRSTYEILSPEDIGIVKSQNSGLVLGKLSGRHAVKDRLK 437 Query 344 QLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEK 390 +LG L + L V +L K +T D+ ++ G + EK Sbjct 438 ELGYELDDEKLNAVFSLFRDLTKNKKRITDADMKALVTSSDGISLEK 484 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Histophilus somni 2336] Sequence ID: B0USF6.1 Length: 517 Range 1: 7 to 443 Score:158 bits(400), Expect:2e-41, Method:Compositional matrix adjust., Identities:130/453(29%), Positives:211/453(46%), Gaps:36/453(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME-- 67 I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALKASLTVKEKLQIA-LALERLGVDVMEVGFPVSSAGDFESVQTIARHI 65 Query 68 -----WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKE 122 A + + + I+I D +K + A ++ S H+E +L +T Sbjct 66 KNSRVCALSRAVDKDIDI--------AADALKVAEAFRIHTFIATSALHVEAKLRRT--- 114 Query 123 FFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 F DV +E AI++ + Y +D + R D + +VE K + +PD Sbjct 115 -FDDV---VEMAIQAVKRARRYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E +D ++ + P+I H HND ++ ANSL A++ G + + +IN Sbjct 171 TVGFCLPTEYGNIIDQVMNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTIN 230 Query 236 GLGERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVG 291 G+GERAGNT LE +V I + + T IN I S++V I N+ IVG Sbjct 231 GIGERAGNTALEEVVMAIKTRQDIFKGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVG 290 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLS 350 + F ++G+H DG K + PE G +K L +G+A++ ++ +G + Sbjct 291 SNAFAHSSGIHQDGMVKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKSHMDAMGYQQN 350 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + L K+ ++L D+ V DL + + E L++ + + A Sbjct 351 DYDLDKLYAAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLSLDVITSQTISNLPASAF 410 Query 411 IELEYQGKIHKEISE-GDGGYDAFMNALTKITN 442 +++E GK ++S G+G DA NA+ IT+ Sbjct 411 VQVELDGKKISQVSNGGNGPVDAVYNAILAITD 443 >RecName: Full=Homocitrate synthase AksA; AltName: Full=(R)-homo(2)citrate synthase; AltName: Full=(R)-homo(3)citrate synthase [Methanopyrus kandleri AV19] Sequence ID: Q8TW28.1 Length: 397 Range 1: 21 to 391 Score:155 bits(393), Expect:2e-41, Method:Compositional matrix adjust., Identities:119/384(31%), Positives:197/384(51%), Gaps:16/384(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 + D TLRDGEQT GVSF+ +KL IA LL +L V ++E VS+GE + V++I Sbjct 21 VYDTTLRDGEQTPGVSFTPEQKLEIA-HLLDELGVQQIEAGFPVVSEGERDAVRRI---- 75 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A E L I L D + +D D V+ + LH L+ +L + +E Sbjct 76 AHEGLNADILCLARTLRGDVDAALDCDVDG---VITFIATSELH-LKHKLRMSREEVLER 131 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++ +EYA GL + ED G R ++++ + + +R+ DT+GV+ P Sbjct 132 IADTVEYAKDHGLWVAFSAED---GTRTEFEFLERVYRTAEECGADRVHATDTVGVMIPA 188 Query 187 ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 V + I++ D+ H H+D+ ++VANSL A+ AG + + ++NG+GERAGN L Sbjct 189 AMRLFV-AKIREVVDLPIGVHCHDDFGMAVANSLAAVEAGAQAISTTVNGIGERAGNAAL 247 Query 247 EALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGD 306 E ++ + + N + E SR V +SG + N+ +VGE+ F +G+H Sbjct 248 EEVIMALKELYGIDPGFNTEVLAELSRKVSEYSGIDVPPNKAVVGENAFRHESGIHVAAV 307 Query 307 KKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGD 366 + PI P+ G R LGK G+ ++ +++LG+ E ++++VL+R+ LGD Sbjct 308 LEEPRTYEPIDPKEVGMNRKIVLGKHTGRKAVVAKLEELGVEPEEEIVEEVLKRIKALGD 367 Query 367 QNKLVTPEDLPFIIADVSGRTGEK 390 + VT L I+ +V G++ Sbjct 368 RRVRVTDSKLEEIVRNVLESRGDR 391 >RecName: Full=2-isopropylmalate synthase 1, chloroplastic; AltName: Full=Methylthioalkylmalate synthase-like 4; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q9LPR4.2 Length: 631 Range 1: 89 to 612 Score:160 bits(404), Expect:3e-41, Method:Compositional matrix adjust., Identities:151/534(28%), Positives:239/534(44%), Gaps:40/534(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + + D TLRDGEQ+ G + ++ EKL+IA+ L KL VD +E SK + E V+ I E Sbjct 89 VRVFDTTLRDGEQSPGATLTSKEKLDIAR-QLAKLGVDIIEAGFPAASKDDFEAVKTIAE 147 Query 68 WAA--TEQLTERIEILGFVDGNK-----TVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 ++ I G NK D +K + ++ S HLE +L KT Sbjct 148 TVGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKKTK 207 Query 121 KEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 E ++ +A G + + ED R+ +Y+ ++ + K + +PDT Sbjct 208 AEVIEIARSMVRFARSLGCEDVEFSPEDAG---RSEREYLYEILGEVIKAGATTLNIPDT 264 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G+ P E Q + L P I H ND LS AN+L AG + + +ING Sbjct 265 VGITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTING 324 Query 237 LGERAGNTPLEALVTTIHDKSNSK-----TNINEIAITEASRLVEVFSGKRISANRPIVG 291 +GERAGN LE +V I + + T I+ I S++VE ++G + ++ IVG Sbjct 325 IGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVG 384 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLGM 347 + F +G+H DG K I PE G +RS LGKL+G+ ++ + + +LG Sbjct 385 ANAFAHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALKDRLTELGY 444 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRP 407 L + L + R + +Q K VT D+ +++D + E V + I G Sbjct 445 QLDDEQLSTIFWRFKTVAEQKKRVTDADIIALVSDEVFQP-EAVWKLLDIQITCGTLGLS 503 Query 408 HAQIEL-EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDA 466 A ++L + GK H S G G D+ A+ I L++Y + G DA Sbjct 504 TATVKLADADGKEHVACSIGTGPVDSAYKAVDLIVKEPAT----LLEYSMNAVTEG-IDA 558 Query 467 LVETRI---------TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + TR+ + N E +TF G D V++V A LN+++ Sbjct 559 IATTRVLIRGSNKYSSTNAITGEEVQRTFSGTGAGMDIVVSSVKAYVGALNKMM 612 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Olsenella uli DSM 7084] Sequence ID: E1QWZ1.1 Length: 511 Range 1: 4 to 442 Score:158 bits(399), Expect:3e-41, Method:Compositional matrix adjust., Identities:124/452(27%), Positives:210/452(46%), Gaps:29/452(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +++I D TLRDGEQ+ G S +T EKL +A+ LL +++VD +E S G+ +VQ+I Sbjct 4 KIDIFDTTLRDGEQSPGASMNTEEKLIVAQQLL-RMHVDVIEAGFPISSPGDFRSVQEIG 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 A + + ++G + VD D A+ L+ + +H HL +L Sbjct 63 RLAGDDAV-----VVGL---TRAVDKDIDRAAEALSCAKRPRIHTGLGVSPQHLADKLRI 114 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + E + YA + + Y ED R +++ +++ + + + +PD Sbjct 115 SEDECVERAIRCVRYAKRYVEDVQFYAEDAG---RADQGFLERVIQAVIEAGATVVNIPD 171 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T G P +G+ ++ ++ H HND ++ A +L + G + +IN Sbjct 172 TTGYQMPAAFGARIKGLCDNVRGIENVTIAVHTHNDLGMATALALAGVENGATQIECTIN 231 Query 236 GLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 GLGERAGNT LE +V + D+ + T++ +T ASRLV +G ++ AN+ IVG Sbjct 232 GLGERAGNTALEEVVMALRMHGDELDGHTDVVTQELTRASRLVSRITGMQVQANKAIVGA 291 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F ++G+H DG K I P G S L +G A++ + +LG E Sbjct 292 NAFAHSSGIHQDGVLKSRGTYEIIDPADVGAAGSEIILSARSGHAALRHRLSELGYSFPE 351 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 V +R +E+ DQ K V EDL ++ + R + ++S + G P A + Sbjct 352 SEFDDVYQRFLEIADQKKEVFDEDLESMVQERQ-RDVTAIYALESVQVVCGDAAIPTATV 410 Query 412 ELEYQ-GKIHKEISEGDGGYDAFMNALTKITN 442 + + G H G G DA A+ K+ + Sbjct 411 HITDEVGGEHVVACTGTGPVDAAYKAIDKVVS 442 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Geobacillus kaustophilus HTA426] Sequence ID: Q5KWJ3.1 Length: 515 Range 1: 3 to 463 Score:158 bits(399), Expect:3e-41, Method:Compositional matrix adjust., Identities:140/475(29%), Positives:225/475(47%), Gaps:26/475(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +++ D TLRDGEQ+ GV+ + EKL IA+ L++L VD +E SKG+ E V++I Sbjct 3 KIKFFDTTLRDGEQSAGVNLNLQEKLEIAR-QLERLRVDIIEAGFPASSKGDFEAVKQIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 E T +T + V + W +K L+L S H+ +L TP++ Sbjct 62 ETVRTCSVTG---LSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVI 118 Query 125 TDVSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 ++YA K + WS + R+ ++ +V + K I +PDT+G Sbjct 119 EAAVEAVKYA-----KRFFPIVQWSAEDACRSELPFLAKIVAEVIKAGASVINIPDTVGY 173 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 ++P+E + L P+I H H+D ++V NSL AI G + +ING+GE Sbjct 174 ITPKEYGEIFLYLQNNVPNIENVSLSAHCHDDLGMAVVNSLSAIEHGATQVECTINGIGE 233 Query 240 RAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE + +H D +T +N I S LV +G + N+ +VG++ F Sbjct 234 RAGNAALEEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGVVVPPNKAVVGKNAFA 293 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K I PE G S LGK +G+ ++ V++LG LS+ + Sbjct 294 HESGIHQDGVLKEKTTYEIISPELVGVPSNSMVLGKHSGRHALRNRVEELGYTLSDEEIN 353 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-E 414 ++ R EL D+ K +T +DL +I + + + S + G P A + L + Sbjct 354 QLFVRFKELADKKKDITDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKD 413 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 +G +E + G G +A N L R + L+DY + GG+ DAL + Sbjct 414 GKGNEIQEAATGAGSVEALYNTL----ERCFQTPVTLLDYRIESVGGGR-DALAQ 463 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539] Sequence ID: Q9RUA9.1 Length: 522 Range 1: 10 to 508 Score:157 bits(398), Expect:4e-41, Method:Compositional matrix adjust., Identities:145/523(28%), Positives:239/523(45%), Gaps:37/523(7%) Query 2 TKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET 61 T + + I D TLRDGEQ+ GV+ + ++KL IA L ++ VD +E S G+LE Sbjct 10 TAPQQHIRIFDTTLRDGEQSPGVALNHAQKLEIAH-TLARMGVDVIEAGFPIASPGDLEG 68 Query 62 VQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 V +I +T + D ++ + ++ S H++K+L P Sbjct 69 VSRIAREVRGPVITA-LARANRADIEAAAKGVEAAEKSRIHTFIATSPIHMQKKLNLEPD 127 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 VIE A+++ Y++D + R+ D++ + + + I +P Sbjct 128 A-------VIERAVEAVRLARQYVDDVEFSAEDATRSEWDFLSRIFKAAVEAGATTINVP 180 Query 178 DTLGVLSPEETFQGVDSLIQKYP-DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 DT+G +PEE + L K P + H H+D ++VANS+ A G + + +ING Sbjct 181 DTVGYTTPEEMRKLFAYLKAKLPAHVILSSHCHDDLGMAVANSIAAAEGGARQIECTING 240 Query 237 LGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 +GERAGN LE +V H D +T I + ASRLV SG + N+ IVG++ Sbjct 241 IGERAGNASLEEIVMAFHTRRDVYGYETGIRTRELYRASRLVSRLSGMPVQPNKAIVGDN 300 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMV-LSE 351 F +G+H DG K + E GR+ + +GK +G+A+ + + LG + + Sbjct 301 AFAHESGIHQDGVIKARETYEIMNAELVGREAAVLVMGKHSGRAAFRKALTDLGYGDIPD 360 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII---ADVSGRTGEKVLTIKSCNIHSGIGIRPH 408 +Q + R +L D+ + EDL ++ +DV + +++ I SG+ + P Sbjct 361 DKVQHLFGRFKDLADRKGQIYAEDLRALVDARSDVP-----QTFSLEGFQITSGMNMMPV 415 Query 409 AQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALV 468 A + L + GDG +A A++KIT GIS P L Y ++ G DAL Sbjct 416 AFVRLHTPDGPVDATAHGDGPVEAAFQAISKIT---GIS-PTLESYRIQSVTRGD-DALG 470 Query 469 ETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 E I + GV D A+ A +++N I+ Sbjct 471 EVSIHVRHG-----ETQLNGTGVATDIVEASARAWIRVMNMIV 508 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter concisus 13826] Sequence ID: A7ZES2.1 Length: 504 Range 1: 3 to 500 Score:157 bits(396), Expect:7e-41, Method:Compositional matrix adjust., Identities:144/522(28%), Positives:235/522(45%), Gaps:38/522(7%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + ++ I D TLRDGEQ+ G S +T+EKL IA L++L VD +E A S G+ + V + Sbjct 3 KNKIIIFDTTLRDGEQSPGASMNTAEKLQIA-LQLERLGVDVMEAGFAAASPGDFDAVNQ 61 Query 65 IMEWAA---TEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPK 121 I + A+ L +E D + + + K ++ S H++ +L +P Sbjct 62 IAKQASNITVCSLARAVE----RDIKAAGEALAPAKNKRIHTFIATSPIHMQYKLKMSPD 117 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 E ++Y+ + ED R+ ++K + E + I +PDT+G Sbjct 118 EVIRCAVEAVQYSKTFCDDVEFSCEDAC---RSEMSFLKEICEAAINAGAKTINIPDTVG 174 Query 182 VLSPEETFQGVDSLIQKYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 L PEE + +++ D H HND ++ ANSL AI+AG + + +ING+GER Sbjct 175 YLYPEEITARISEIVKFIGDRAVVSVHNHNDLGMATANSLAAIKAGARQVEGTINGIGER 234 Query 241 AGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 AGN LE +V I + + T I I SRL+ +G N+ IVG++ F Sbjct 235 AGNAALEEIVMAIKTRQDVFAPLYTGIISKEIYPTSRLIASITGIEPQPNKAIVGKNAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 +G+H DG K I E G K S LGK +G+ + + + LG L L Sbjct 295 HESGIHQDGVLKHKETYEIISAESIGLEKNSLVLGKHSGRHAFKDKLASLGFDLDSDALN 354 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCN-----IHSGIGIRPHAQ 410 K E+ +L D+ K + +D+ ++A E++ I + S G A Sbjct 355 KAFEKFKDLADKKKEIFDDDIRALVA-------EEITKIPQAYEITDLLQSSGGSLASAS 407 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 + + + +I + + G+G DA + +I+ G L DY+V GK DAL + Sbjct 408 MSIRHNDEIVSDSALGNGTADAIFKVVDRISGINGT----LKDYKVTAVSQGK-DALAKV 462 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQ 512 + ++ E G+ D +A+ A LN L+ Sbjct 463 DV----KVEFEGKTAVMGHGLDIDTMMASAKAYVGALNSYLR 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Histophilus somni 129PT] Sequence ID: Q0I2G1.1 Length: 517 Range 1: 7 to 443 Score:157 bits(396), Expect:7e-41, Method:Compositional matrix adjust., Identities:129/453(28%), Positives:211/453(46%), Gaps:36/453(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME-- 67 I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALKASLTVKEKLQIA-LALERLGVDVMEVGFPVSSAGDFESVQTIARHI 65 Query 68 -----WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKE 122 A + + + I+I D +K + A ++ S H+E +L +T Sbjct 66 KNSRVCALSRAMDKDIDI--------AADALKVAEAFRIHTFIATSALHVEAKLRRT--- 114 Query 123 FFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 F DV +E AI++ + Y +D + R D + +VE K + +PD Sbjct 115 -FDDV---VEMAIQAVKRARRYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E ++ ++ + P+I H HND ++ ANSL A++ G + + +IN Sbjct 171 TVGFCLPTEYGNIINQVMNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTIN 230 Query 236 GLGERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVG 291 G+GERAGNT LE +V I + + T IN I S++V I N+ IVG Sbjct 231 GIGERAGNTALEEVVMAIKTRQDIFKGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVG 290 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLS 350 + F ++G+H DG K + PE G +K L +G+A++ ++ +G + Sbjct 291 SNAFAHSSGIHQDGMVKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKSHMDAMGYQQN 350 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + L K+ ++L D+ V DL + + E L++ + + A Sbjct 351 DYDLDKLYAAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLSLDVITSQTISNLPASAF 410 Query 411 IELEYQGKIHKEISE-GDGGYDAFMNALTKITN 442 +++E GK ++S G+G DA NA+ IT+ Sbjct 411 VQVELDGKKISQVSNGGNGPVDAVYNAILAITD 443 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Lysinibacillus sphaericus C3-41] Sequence ID: B1HR98.1 Length: 511 Range 1: 3 to 467 Score:157 bits(396), Expect:8e-41, Method:Compositional matrix adjust., Identities:136/480(28%), Positives:224/480(46%), Gaps:29/480(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +++I D TLRDGEQ+ G++ +T+EK+ IAK L++L V +E S G+ + V +I Sbjct 3 KIDIFDTTLRDGEQSAGINLNTAEKIEIAK-QLERLGVTIIEAGFPASSPGDFDAVHRIA 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 E +T + D + T + IK + +++ S H+E +L K+P++ Sbjct 62 ETVKNSVVTGLARCIQ-KDIDTTWEAIKGAQQPHIHIFLATSPIHMEYKLKKSPEQVIEQ 120 Query 127 VSFVIEYAIKSGLKINVYLEDWS--NGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 ++YA K L WS + FR+ +++ ++ + I +PDT+G S Sbjct 121 AVEAVKYAKKY-----FPLVQWSAEDAFRSDREFLVRIMNEVVTAGATTINVPDTVGYAS 175 Query 185 PEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERA 241 P E F+ + ++ + F H H+D ++ AN+L AI G + +ING+GERA Sbjct 176 PYEYGALFKYLLENVKGADKVKFSAHCHDDLGMATANTLAAIENGAAQVEGTINGIGERA 235 Query 242 GNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 GN LE + +H D +T I I S+LV + I N+ IVG + F Sbjct 236 GNVALEEIAVALHIRKDYYQVETGIQLQEIKRTSQLVSKLTNVVIQPNKAIVGRNAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K I P G LGK +G+A+ + + LG LS+ L K Sbjct 296 SGIHQDGVLKNPETYEIISPALIGEGEIPLVLGKHSGRAAFRDRAETLGFDLSDEKLNKA 355 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGE-KVLTIKSCNIHSGIGIRPHA-QIELEY 415 +L D+ K +T EDL ++ + + + + +K + G P A I L Sbjct 356 FVEFKKLADRKKEITEEDLLTLLTEQQIQLEDVPLFELKMVQVQYGTENIPTATAIVLTP 415 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPK---LIDYEVRIPPGGKTDALVETRI 472 +G ++ G G +A N L ++ +P +IDY V G+ DAL E + Sbjct 416 EGLEKTVVATGAGSVEAIFNTLEQL-------VPNAVHVIDYRVTSVGKGR-DALGEAVV 467 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Serratia proteamaculans 568] Sequence ID: A8G9R1.1 Length: 524 Range 1: 7 to 505 Score:157 bits(396), Expect:8e-41, Method:Compositional matrix adjust., Identities:142/528(27%), Positives:240/528(45%), Gaps:50/528(9%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EK+ IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKIQIA-MALERMGVDVMEVGFPVSSPGDFESVQTIARQI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 + + G + VD D A+ L + +H H+E +L ++ Sbjct 66 KNSR------VCGLA---RCVDKDIDVAAEALRVAEAFRIHVFLATSTLHIESKLKRSFD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 E V+E AI+S + Y +D + R D + +VE I +P Sbjct 117 E-------VLEMAIRSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAINAGATTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G +P + + +L + P+I H H+D ++V NS+ A++AG + + ++ Sbjct 170 DTVGYTTPNQFGGIITTLYDRVPNIDKAIISVHCHDDLGMAVGNSIAAVQAGARQVEGTL 229 Query 235 NGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGNT LE ++ I D N TNIN I S++V I AN+ IVG Sbjct 230 NGIGERAGNTSLEEVIMAIKVRQDIMNVHTNINHQEIFRTSQIVSQLCNMPIPANKAIVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLS 350 + F ++G+H DG K + P+ G K L +G+A++ ++ +G Sbjct 290 SNAFAHSSGIHQDGVLKNRENYEIMSPQTIGLKDVQLNLTSRSGRAAVKHRMEGMGYKEQ 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 + L + ++L D+ V DL + + + ++ ++ SG I A Sbjct 350 DYNLDNLYAAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFSLDYFSVQSGSSIMATAS 409 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--V 468 ++L + E + G+G DA A+ +IT G I +L+ Y++ G+ DAL V Sbjct 410 VKLICGEEEKAEAATGNGPVDAVYQAINRIT---GYPI-ELVKYQLTAKGQGR-DALGQV 464 Query 469 ETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + +++N + F +G+ D ++ A +LN I + Q+ Sbjct 465 DIVVSYN-------GRRFHGVGLATDIVESSAKAMVHVLNNIWRSQQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Macrosiphoniella ludovicianae)] Sequence ID: Q9EVG4.1 Length: 502 Range 1: 1 to 493 Score:156 bits(394), Expect:1e-40, Method:Compositional matrix adjust., Identities:145/514(28%), Positives:239/514(46%), Gaps:35/514(6%) Query 17 DGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQLTE 76 DGEQ S S EKL IA L+K+ VD +EI S G+ ++VQ I + ++ Sbjct 1 DGEQALQASLSVKEKLQIA-LCLEKIGVDIMEIGFPISSPGDFKSVQIISKNIKNSRICS 59 Query 77 RIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSFVIEYAIK 136 + D + + + S + +++ S H+E +L K E F ++ A++ Sbjct 60 LARCVE-KDIDAAGEAMSASNSFRIHIFLATSTLHMEYKLKKNFHEIIDMAIFAVKRALR 118 Query 137 SGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLI 196 I ED S R + D + +VE L ++ I +PDT+G P E + +L+ Sbjct 119 YTDDIEFSCEDAS---RTTIDNLCRIVEKLIYHGVKTINIPDTVGYTVPNELSYIIKNLL 175 Query 197 QKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTI 253 ++ P+IH H H+D ++V NS+ AI+AG + + +ING+GERAGNT LE ++ I Sbjct 176 ERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235 Query 254 ---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGN 310 D TNIN I S+++ I N+ IVG + F+ ++G+H DG K Sbjct 236 KVREDILGVSTNINYKEIYHTSKIISRICNMPIPPNKAIVGSNAFSHSSGIHQDGVLKNR 295 Query 311 LYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNK 369 I P G +K L +G+A++ + ++G ++ + ++ ++L D+ Sbjct 296 KNYEIIDPSSIGFKKLKLNLTSRSGRAAVKYYMSEMGYKDTDYNIDELYADFLKLADKKG 355 Query 370 LVTPEDLPFIIADVSGRTGE------KVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEI 423 V DL +A +S E K +++S I +G+ A I+L K++ E Sbjct 356 QVFDYDLES-LAFISKHPEELEHFCLKFFSVQS--ISNGLST---ASIKLLCGQKLYIES 409 Query 424 S-EGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEE 482 S +G DA AL KITN P ++ I G DAL + I L + Sbjct 410 STTSNGPVDAIYQALNKITN-----FPIILQKFQLIAKGKGKDALGQVNI-----LIEYK 459 Query 483 DQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I Q Q+ Sbjct 460 KRKFHGIGLATDFIESSAKAMVNVLNNIWQAEQV 493 >RecName: Full=Homocitrate synthase AksA; AltName: Full=(R)-homo(2)citrate synthase; AltName: Full=(R)-homo(3)citrate synthase [Methanosarcina acetivorans C2A] Sequence ID: Q8TKQ6.1 Length: 405 Range 1: 23 to 389 Score:154 bits(389), Expect:1e-40, Method:Compositional matrix adjust., Identities:117/379(31%), Positives:188/379(49%), Gaps:15/379(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 +EI DVTLRDGEQT GV F+ +KL +A L + ++ +E VS E E V++I Sbjct 23 IEICDVTLRDGEQTPGVVFTKEQKLAVAS-ELDSMGIEVIEAGFPVVSAYEKEIVKEI-- 79 Query 68 WAATEQLTERIEILG-FVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + RI L V G+ VD D ++++ S HL+ + +T ++ Sbjct 80 --ANQGYDSRICCLSRAVKGD--VDAALDCDVDIVSIFIAMSDMHLKYKYHRTLEDMLGC 135 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH-IERIFLPDTLGVLSP 185 IEYA GL + ED S R D +K + + E+ ++ + L DT+G+L+P Sbjct 136 AKEAIEYATDHGLNVRFAAEDAS---RTPIDRLKQAFKEVENEYKVQYVSLADTIGILNP 192 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 T V S I K + H H+D ++ AN+L A AG K LH ++NG+GERAGN Sbjct 193 TTTHYLV-SEIFKCVNTSICIHCHDDLGMATANTLAAAEAGAKQLHTTVNGIGERAGNAS 251 Query 246 LEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 LE ++ + + + + +T SR++ +S S N+ +VG++ FT +G+H Sbjct 252 LEEMLVALRVQYGIE-RYDTTKLTALSRMISEYSNITPSVNKAVVGQNAFTHESGIHVAA 310 Query 306 DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELG 365 + LPE G KR+ +GK G ++ + +G L L ++E+V Sbjct 311 ILEEPRTYELFLPEMVGGKRNLVVGKHTGTKALKGIINSIGFCLEREELCALIEKVKVCT 370 Query 366 DQNKL-VTPEDLPFIIADV 383 D+ + ++ E L +IA V Sbjct 371 DEKRRSISREQLEKLIAQV 389 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella sediminis HAW-EB3] Sequence ID: A8FQ83.1 Length: 523 Range 1: 1 to 498 Score:156 bits(394), Expect:2e-40, Method:Compositional matrix adjust., Identities:143/525(27%), Positives:238/525(45%), Gaps:47/525(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ +VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLTVKEKLQIA-LSLERLGVDVMEVGFPVSSPGDFNSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L + ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ANTVKNSRVCALA-----RALEKDIDAAAQSLSVADQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE K I Sbjct 111 LKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEEAIKAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E +++L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTIPSEFGGIIETLFNRVPNIDQAIISVHCHDDLGLSVANSITAVQQGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + + + +S +T IN I S LV + AN+ I Sbjct 228 TVNGIGERAGNCSLEEIAMILSTRKDSLGLETGINAKEIHRTSNLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKSQNTYEIMTPESIGLHRNNLNMTSRSGRHVIKHRMEEMGYG 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPED---LPFIIADVSGRTGEKVLTIKSCNIHS-GIG 404 + + + E ++L D+ V D L F+ A V K+ + +HS Sbjct 348 NKDYDMDTLYEAFLQLADKKGQVFDYDLEALAFMEAQVDEEADYKLAQLV---VHSDSTE 404 Query 405 IRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITN-RLGISIPKLIDYEVRIPPGGK 463 A ++LE GK E + G+G DA NA+ + + + I+ KL G Sbjct 405 GNATATVKLEIDGKTVTEAATGNGPVDAAYNAIARASQCEVNITSYKL------SAKGEG 458 Query 464 TDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 +AL + I N + +Q+F +G+ D A+V A ++N Sbjct 459 QNALGQVDIEANYN-----EQSFHGVGLATDVVEASVQALVHVMN 498 >RecName: Full=Homocitrate synthase [Cereibacter sphaeroides] Sequence ID: Q01181.1 Length: 391 Range 1: 19 to 384 Score:153 bits(387), Expect:2e-40, Method:Compositional matrix adjust., Identities:116/380(31%), Positives:179/380(47%), Gaps:20/380(5%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEI---ASARVSKGELETVQK 64 + + D TLRDGEQT GV+F+ +EK IA+ LQ V VE+ A + ++ V Sbjct 19 VALCDTTLRDGEQTAGVAFTRAEKRAIAE-ALQAAGVAEVEVGVPAMGEEERADIRAVAA 77 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 +++ AA R+ +T G L++ S + +LGK Sbjct 78 VLKTAAPVVWC-RLRAEDLAAAQRT-------GVVRLHIGVPVSERQISAKLGKDAAWVR 129 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 V ++ A +G K++V ED S R P ++ + ++ R + DTLGVL Sbjct 130 DKVEKLVRAASWAGHKVSVGAEDAS---RADPFFLAEIAHVAAEAGAIRFRISDTLGVLD 186 Query 185 PEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 P + V ++ + P + EFHGHND ++ ANSL A RAG L ++NGLGERAGN Sbjct 187 PFAAHELVGRVVTRCP-LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERAGNA 245 Query 245 PLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 V + + T + + S LV SG+ +S +PIVGE VFT G+H D Sbjct 246 -ALEEVAAALEAAGRATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIHVD 304 Query 305 G--DKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVI 362 G + + + PERFGR A+GK + A ++ + + G+ L ++ + Sbjct 305 GLMKDRATYESADLRPERFGRSHRIAIGKHSSAAGLARALAEAGLPADAATLAALMPALR 364 Query 363 ELGDQNK-LVTPEDLPFIIA 381 + K PEDL ++A Sbjct 365 DWAAITKRAAAPEDLAALLA 384 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Streptococcus gallolyticus UCN34] Sequence ID: D3HCJ2.1 Length: 520 Range 1: 3 to 379 Score:155 bits(393), Expect:2e-40, Method:Compositional matrix adjust., Identities:117/385(30%), Positives:187/385(48%), Gaps:18/385(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 ++E LD TLRDGEQT GV+FS EK+ IAK L+K + +E S E V++I Sbjct 3 KVEFLDTTLRDGEQTPGVNFSIKEKVAIAK-QLEKWGIASIEAGFPAASPDSFEAVRQIS 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 M A L ++ D + + +KD+ ++ S H E +L KT +E Sbjct 62 AAMTTTAVSGLARSVK----SDIDACYEALKDAKYPQCHVFIATSPIHREYKLKKTKEEI 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + + YA + ED + R DY+ +V+ I +PDT+G Sbjct 118 LDIIKEHVTYARSKFDVVEFSPEDAT---RTELDYLLQVVQTAVDAGATYINIPDTVGFT 174 Query 184 SPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +PEE LI+ +I F H H+D ++ AN+L AI+ G + ++NG+GER Sbjct 175 TPEEYGNIFKYLIENTKSDREIIFSPHCHDDLGMATANTLAAIKNGAGRVEGTVNGIGER 234 Query 241 AGNTPLEALVTTIHDKSNSKTNINEIAITE---ASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGN LE + ++ + + ++I + E S L+ FSG I N+ +VG + F+ Sbjct 235 AGNVALEEIAVALNIREDYYQATSDIVLNETVNTSELISRFSGISIPKNKAVVGGNAFSH 294 Query 298 TAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K L I PE G K S LGKL+G+ + E +K+L + E + Sbjct 295 ESGIHQDGVLKNPLTYEIITPELVGVKHNSLPLGKLSGRHAFVEKLKELELAFEESEIAT 354 Query 357 VLERVIELGDQNKLVTPEDLPFIIA 381 + + +L D+ +T D+ ++A Sbjct 355 LFGKFKKLADKKHEITDADIRALVA 379 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella sp. ANA-3] Sequence ID: A0L1R0.1 Length: 522 Range 1: 1 to 498 Score:155 bits(393), Expect:3e-40, Method:Compositional matrix adjust., Identities:141/526(27%), Positives:242/526(46%), Gaps:49/526(9%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ ++ ++YA + + ED R D + +VE I Sbjct 111 LKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAIHAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D +SVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + + + N +T IN I S LV I +N+ I Sbjct 228 TMNGIGERAGNCSLEEIAMILATRKNLLGVETGINAKEIHRTSNLVSQLCNMPIQSNKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE------KVLTIKSCNIHSG 402 + L + E+ + L D+ V DL +A + + E + L ++S + G Sbjct 348 EQDFNLDALYEQFLHLADKKGQVFDYDLE-ALAFMEAQAAEDNFYQLQQLVVQS-DSTEG 405 Query 403 IGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGG 462 + A + ++ G+I E + G+G DA NA+ + T+R +I Y++ G Sbjct 406 VAT---ATVRIDVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGEG 458 Query 463 KTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 + +AL + IT + +Q F +G+ D A+ A ++N Sbjct 459 Q-NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella sp. MR-4] Sequence ID: Q0HE65.1 Length: 522 Range 1: 1 to 498 Score:155 bits(392), Expect:3e-40, Method:Compositional matrix adjust., Identities:141/526(27%), Positives:242/526(46%), Gaps:49/526(9%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ ++ ++YA + + ED R D + +VE I Sbjct 111 LKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAIHAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D +SVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + + + N +T IN I S LV I +N+ I Sbjct 228 TMNGIGERAGNCSLEEIAMILATRKNLLGVETGINAKEIHRTSNLVSQLCNMPIQSNKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE------KVLTIKSCNIHSG 402 + L + E+ + L D+ V DL +A + + E + L ++S + G Sbjct 348 EQDYNLDALYEQFLHLADKKGQVFDYDLE-ALAFMEAQAAEDNFYQLQQLVVQS-DSTEG 405 Query 403 IGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGG 462 + A + ++ G+I E + G+G DA NA+ + T+R +I Y++ G Sbjct 406 VAT---ATVRIDVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGEG 458 Query 463 KTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 + +AL + IT + +Q F +G+ D A+ A ++N Sbjct 459 Q-NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xylella fastidiosa 9a5c] Sequence ID: Q9PCG3.1 Length: 519 Range 1: 11 to 444 Score:155 bits(392), Expect:3e-40, Method:Compositional matrix adjust., Identities:128/451(28%), Positives:215/451(47%), Gaps:33/451(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G S +KL +A+ L L VD +E S+ + E M Sbjct 11 RIRIFDTTLRDGEQSPGCSMPAQQKLVMAR-ALDALGVDIIETGFPASSQSDYEA----M 65 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 A E + +L ++ + ++ A+ L TK LH H E +L Sbjct 66 TLIARELRRPTLAVL-----SRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRM 120 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ V + + + ED + R D++ + I LPD Sbjct 121 SKEQVLESVHKHVSLSRTLIDDVEFSAEDAT---RTEEDFLIEVTRVAIAAGATTINLPD 177 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +PEE F + + ++ + F H H+D L+VANSL AI G + + +IN Sbjct 178 TVGFSTPEEIRNMFTRIIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTIN 237 Query 236 GLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE L + ++ N T+I+ I S+L++ G + N+ +VG Sbjct 238 GIGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGA 297 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRSY-ALGKLAGKASISENVKQLGMVLSE 351 + F +G+H G + + P+ G S+ LG+ +G+A++ + ++ LG +L E Sbjct 298 NAFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEE 357 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L+ V E +L ++ +LVT DL ++ D + + G ++ ++ S IG R +A + Sbjct 358 EDLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTI----SDIGNRANALV 413 Query 412 EL-EYQGKIHKEISEGDGGYDAFMNALTKIT 441 EL + QG+ E ++G+G DA AL T Sbjct 414 ELSDPQGQRVAETAQGNGPVDALFGALAAAT 444 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella sp. MR-7] Sequence ID: Q0HZT4.1 Length: 522 Range 1: 1 to 498 Score:155 bits(392), Expect:3e-40, Method:Compositional matrix adjust., Identities:141/526(27%), Positives:241/526(45%), Gaps:49/526(9%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ ++ ++YA + + ED R D + +VE I Sbjct 111 LKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAIHAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D +SVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + + + N +T IN I S LV I +N+ I Sbjct 228 TMNGIGERAGNCSLEEIAMILATRKNLLGVETGINAKEIHRTSNLVSQLCNMPIQSNKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE------KVLTIKSCNIHSG 402 L + E+ + L D+ V DL +A + + E + L ++S + G Sbjct 348 EQNYNLDALYEQFLHLADKKGQVFDYDLE-ALAFMEAQAAEDNFYQLQQLVVQS-DSTEG 405 Query 403 IGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGG 462 + A + ++ G+I E + G+G DA NA+ + T+R +I Y++ G Sbjct 406 VAT---ATVRIDVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLSAKGEG 458 Query 463 KTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 + +AL + IT + +Q F +G+ D A+ A ++N Sbjct 459 Q-NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus epidermidis RP62A] Sequence ID: Q5HMF9.1 Length: 511 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus epidermidis ATCC 12228] Sequence ID: Q8CNL3.1 Length: 511 Range 1: 1 to 471 Score:155 bits(391), Expect:3e-40, Method:Compositional matrix adjust., Identities:137/488(28%), Positives:228/488(46%), Gaps:33/488(6%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 +E ++I D TLRDGEQT GV+F+ E+L IAK L+K VD +E S G ++V+ Sbjct 1 MEEHIQIFDTTLRDGEQTPGVNFTFDERLKIAK-QLEKWGVDVLEAGFPASSTGSFKSVE 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGK 118 I + T + G K+ +D + K++ +++ S HLE +L Sbjct 60 AIAKTLTT------TAVCGLARCKKSDIDAVYEATKEAVKPQVHVFIATSPIHLEHKLKM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T E T + + YA + + ED + R ++ V+ I +PD Sbjct 114 TQDEVLTSIKEHVSYAKQFFEVVQFSPEDAT---RTEIPFLIECVQTAINAGATIINIPD 170 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E F+ + ++ I F H H+D ++VANSL AI G + + ++N Sbjct 171 TVGFSYPTEYGEIFKQLTQAVKSNSKIIFSAHCHDDLGMAVANSLAAIEGGARRIEGTVN 230 Query 236 GLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + ++ D ++ IN + S L+ ++G R+ N+ IVG+ Sbjct 231 GIGERAGNASLEEVALALYVRKDHYGLESQINLEETKKTSDLISRYAGIRVPRNKAIVGQ 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F+ +G+H DG K + P+ G + LGKL+GK + +E +K LG + Sbjct 291 NAFSHESGIHQDGVLKHRETYEIMTPQLVGVNTTELPLGKLSGKHAFAEKLKALGYEIKL 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNI---HSGIGIRPH 408 + ++ E+ D+ K V+ D+ II G E + N+ + G++ Sbjct 351 EDQVTLFKQFKEIADKKKNVSDRDIHAII---HGSEHEHNAIFQLDNLQLQYVSKGLQSA 407 Query 409 AQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEV-RIPPGGKTDAL 467 + E G++ ++ S G G A NA+ +I + +LIDY + + G A Sbjct 408 VVVIKERNGQVKQDSSIGTGSIVAIYNAVDRIFKKDA----ELIDYRIDSVTEGTDAQAE 463 Query 468 VETRITWN 475 V RI N Sbjct 464 VHVRIIIN 471 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus cereus Q1] Sequence ID: B9IUZ0.1 Length: 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus cereus ATCC 10987] Sequence ID: Q73BA0.1 Length: 506 Range 1: 6 to 465 Score:155 bits(391), Expect:4e-40, Method:Compositional matrix adjust., Identities:128/474(27%), Positives:225/474(47%), Gaps:25/474(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI---M 66 +D TLRDGEQ+ GV+ + EKL IA+ L++L + +E A S+G+ ++V++I + Sbjct 6 FMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGIHVMEAGFAAASEGDFQSVKRIANTI 64 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A L E D + + +K + + L++ S H++ +L + ++ Sbjct 65 QNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDS 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + + ED + R + D++ VE + I +PDT+G +PE Sbjct 121 IHRSVTLGKSLFPTVQFSAEDAT---RTARDFLAEAVEVAIRAGANVINIPDTVGYTNPE 177 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + L + P F H H+D ++VANSL A+ G + +ING+GERAGN Sbjct 178 EYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGN 237 Query 244 TPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE + +H D ++ ++ I S LV +G + N+ IVG + F +G Sbjct 238 AALEEVAVALHIRKDFYQAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESG 297 Query 301 VHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K I PE G ++ + LGK +G+ + +E +K+LG + V E Sbjct 298 IHQDGVLKEVTTYEIIEPELVGESQNLFVLGKHSGRHAFTEKMKELGYEFTTEERDAVFE 357 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQGK 418 +L D+ K +T EDL ++ + ++ I +H A + L + +G Sbjct 358 AFKKLADRKKEITEEDLRALMLGEAAFAAQQ-YNITQLQVHFVSNSTQCATVVLKDEEGN 416 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + ++ + G G +A NA+ +I LG+ +L DY ++ G+ DAL + Sbjct 417 VFEDAATGSGSIEAIYNAIQRI---LGLEC-ELADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus anthracis str. CDC 684] Sequence ID: C3L9Q7.1 Length: 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus anthracis str. A0248] Sequence ID: C3P4Z6.1 Length: 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus anthracis] Sequence ID: Q81T68.1 Length: 506 Range 1: 6 to 465 Score:154 bits(390), Expect:4e-40, Method:Compositional matrix adjust., Identities:130/476(27%), Positives:226/476(47%), Gaps:29/476(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI---M 66 +D TLRDGEQ+ GV+ + EKL IA+ L++L + +E A S+G+ ++V++I + Sbjct 6 FMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGIHVMEAGFAAASEGDFQSVKRIANTI 64 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A L E D + + +K + + L++ S H++ +L + ++ Sbjct 65 QNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDS 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + + ED + R + D++ VE + I +PDT+G +PE Sbjct 121 IYRSVTLGKSLFPTVQFSAEDAT---RTARDFLAEAVEVAIRAGANVINIPDTVGYTNPE 177 Query 187 ET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E F+ + + Y F H H+D ++VANSL A+ G + +ING+GERAGN Sbjct 178 EYYALFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGN 237 Query 244 TPLEALVTTIH-----DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 LE + +H K+ + EI T S LV +G +S N+ IVG + F Sbjct 238 AALEEVAVALHIRKDFYKAEPSMTLKEIKAT--STLVSRLTGMVVSKNKAIVGANAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K I P G ++ + LGK +G+ + +E +K+LG + V Sbjct 296 SGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAV 355 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQ 416 E +L D+ K +T EDL ++ + ++ I +H A + L + + Sbjct 356 FEAFKKLADRKKEITEEDLRALMLGEAAFAAQQ-YNITQLQVHFVSNSTQCATVVLKDEE 414 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G + ++ + G G +A NA+ +I LG+ +L DY ++ G+ DAL + Sbjct 415 GNVFEDAATGSGSIEAIYNAIQRI---LGLEC-ELADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=Methylthioalkylmalate synthase 1-2, chloroplastic; Short=EjMAM1-2; Flags: Precursor [Eutrema japonicum] Sequence ID: P0DO78.1 Length: 503 Range 1: 85 to 474 Score:154 bits(390), Expect:5e-40, Method:Compositional matrix adjust., Identities:116/393(30%), Positives:195/393(49%), Gaps:23/393(5%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + + D TLRDGEQ G + + +KL IA+ L KL VD +E+ S+ E ETV+ I + Sbjct 85 VRVFDTTLRDGEQAPGGALTPPQKLEIAR-KLAKLRVDVMEVGFPGSSEEEFETVKTIAK 143 Query 68 WAATE--QLTERIEILGFVDGNKTVD----W--IKDSGAKVLNLLTKGSLHHLEKQLGKT 119 E + T I ++ + +K D W +K + + + T S H++ +L KT Sbjct 144 TVGNEVDEETGYIPVICAIARSKQRDIEAAWEAVKYAKRPKILIFTSTSDIHMKYKLKKT 203 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 +E + I +A G I+V L +G R+ +++ ++ K + + DT Sbjct 204 KEEVIEMATSSIRFAKSLGF-IDVQL-GCEDGGRSEKEFLCKILGEAIKAGATAVNVADT 261 Query 180 LGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G+ PEE + V L P DI F H HND ++ AN++ + AG + + ++NG Sbjct 262 VGINMPEEYGELVRYLKANTPGIDDIVFSVHCHNDLGVATANTIAGVCAGARQVEVTVNG 321 Query 237 LGERAGNTPLEALVTTIHDKS-----NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 +GER+GN PLE +V + + T I+ I S++V+ ++G + ++PIVG Sbjct 322 IGERSGNAPLEEVVMALKCRGAYVMDGVYTRIDTRQIMATSKMVQEYTGLYVQPHKPIVG 381 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLGM 347 + F +GVH DG K + PE G +S LGKL+G+ ++ + +K+LG Sbjct 382 ANCFVHESGVHQDGILKNRSTYEILSPEDVGVVKSQNSGIVLGKLSGRHAVKDRLKELGY 441 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFII 380 L + + R +L Q K +T DL ++ Sbjct 442 ELDDEKFNDIFSRFRDLTKQKKRITDADLKALV 474 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus MW2] Sequence ID: P58899.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus MSSA476] Sequence ID: Q6G7Q1.1 Length: 509 Range 1: 1 to 491 Score:154 bits(389), Expect:6e-40, Method:Compositional matrix adjust., Identities:138/513(27%), Positives:243/513(47%), Gaps:36/513(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + + ++I D TLRDGEQT GV+F+ E+L IA L+K VD +E S G ++VQ Sbjct 1 MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIA-LQLEKWGVDVIEAGFPASSTGSFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGK 118 I + T + G K+ +D + KD+ V+++ S HLE +L Sbjct 60 AIAQTLTT------TAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ + + YA + + ED + R ++ V+ I +PD Sbjct 114 SQEDVLASIKEHVTYAKQLFDVVQFSPEDAT---RTELPFLVKCVQTAVDAGATVINIPD 170 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +E F+ + + +I + H H+D ++V+NSL AI G + + ++N Sbjct 171 TVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVN 230 Query 236 GLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + ++ D ++T +N + S L+ ++G R+ N+ IVG+ Sbjct 231 GIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQ 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F+ +G+H DG K + P+ G + LGKL+GK + SE +K LG + + Sbjct 291 NAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYGIDK 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII--ADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 + ++ + D+ K V+ D+ II ++ + K+ T++ + S G++ Sbjct 351 EAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSS--GLQSAV 408 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + + +G I+++ S G G A NA+ +I + +LIDY + G TDA E Sbjct 409 VVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKE----TELIDYRINSVTEG-TDAQAE 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHA 502 + L E +T G+ D A+ A Sbjct 464 VHVNL-----LIEGKTVNGFGIDHDILQASCKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella loihica PV-4] Sequence ID: A3QIP0.1 Length: 523 Range 1: 1 to 498 Score:154 bits(390), Expect:6e-40, Method:Compositional matrix adjust., Identities:141/521(27%), Positives:235/521(45%), Gaps:39/521(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLTVKEKLQIA-LSLERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L + ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCALA-----RALEKDIDAAAQSLSVAEQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE K + I Sbjct 111 LKRSFDQVLDMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAIKAGAKTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGGIIQNLFDRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + I + S +T IN I S LV + AN+ I Sbjct 228 TVNGIGERAGNCSLEEIAMIIATRKASLGLETGINAKEIHRTSNLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGVLKSQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYG 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHS-GIGIRP 407 + + + E ++L D+ V DL ++ + E ++ +HS + Sbjct 348 EQDYDMDTLYEAFLKLADKKGQVFDYDLEALVYVEAQAEDENHYGLQQLVVHSDSTQGQA 407 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 A + L GK E + G+G DA A+ + + G I + Y++ G+ DAL Sbjct 408 TATVTLSIDGKAVTEAATGNGPVDAAYKAIARAS---GCEI-NISSYQLSAKGQGQ-DAL 462 Query 468 VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 + IT DQ+F +G+ D A+ A ++N Sbjct 463 GQVDITAKY-----HDQSFHGVGLATDVVEASAAALIHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus thuringiensis str. Al Hakam] Sequence ID: A0RBL2.1 Length: 506 Range 1: 3 to 465 Score:154 bits(389), Expect:7e-40, Method:Compositional matrix adjust., Identities:130/479(27%), Positives:226/479(47%), Gaps:29/479(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 ++ +D TLRDGEQ+ GV+ + EKL IA+ L++L + +E A S+G+ ++V++I Sbjct 3 KILFMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGIHVMEAGFAAASEGDFQSVKRIA 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ A L E D + + +K + + L++ S H++ +L + ++ Sbjct 62 NTIQNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + + + ED + R S D++ VE + I +PDT+G Sbjct 118 LDSIYRSVTLGKSLFPTVQFSAEDAT---RTSRDFLAEAVEVAIRAGANVINIPDTVGYT 174 Query 184 SPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +PEE + L + P F H H+D ++VANSL A+ G + +ING+GER Sbjct 175 NPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGER 234 Query 241 AGNTPLEALVTTIH-----DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 AGN LE + +H K+ + EI T S LV +G + N+ IVG + F Sbjct 235 AGNAALEEVAVALHIRKDFYKAEPSMTLKEIKAT--STLVSRLTGMVVPKNKAIVGANAF 292 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVL 354 +G+H DG K I P G ++ + LGK +G+ + +E +K+LG + Sbjct 293 AHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDER 352 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL- 413 V E +L D+ K +T EDL ++ + ++ I +H A + L Sbjct 353 DAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQ-YNITQLQVHFVSNSTQCATVVLK 411 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + +G + ++ + G G +A NA+ +I LG+ +L DY ++ G+ DAL + Sbjct 412 DEEGNVFEDAATGSGSIEAIYNAIQRI---LGLEC-ELADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus str. Newman] Sequence ID: A6QIQ3.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus USA300_TCH1516] Sequence ID: A8Z4W0.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus USA300] Sequence ID: Q2FF67.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus NCTC 8325] Sequence ID: Q2FWK3.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus COL] Sequence ID: Q5HEE4.1 Length: 509 Range 1: 1 to 491 Score:154 bits(388), Expect:8e-40, Method:Compositional matrix adjust., Identities:138/513(27%), Positives:243/513(47%), Gaps:36/513(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + + ++I D TLRDGEQT GV+F+ E+L IA L+K VD +E S G ++VQ Sbjct 1 MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIA-LQLEKWGVDVIEAGFPASSTGSFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGK 118 I + T + G K+ +D + KD+ V+++ S HLE +L Sbjct 60 AIAQTLTT------TAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ + + YA + + ED + R ++ V+ I +PD Sbjct 114 SQEDVLASIKEHVTYAKQLFDVVQFSPEDAT---RTELPFLVKCVQTAVDAGATVINIPD 170 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +E F+ + + +I + H H+D ++V+NSL AI G + + ++N Sbjct 171 TVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVN 230 Query 236 GLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + ++ D ++T +N + S L+ ++G R+ N+ IVG+ Sbjct 231 GIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQ 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F+ +G+H DG K + P+ G + LGKL+GK + SE +K LG + + Sbjct 291 NAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYDIDK 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII--ADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 + ++ + D+ K V+ D+ II ++ + K+ T++ + S G++ Sbjct 351 EAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSS--GLQSAV 408 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + + +G I+++ S G G A NA+ +I + +LIDY + G TDA E Sbjct 409 VVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKE----TELIDYRINSVTEG-TDAQAE 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHA 502 + L E +T G+ D A+ A Sbjct 464 VHVNL-----LIEGKTVNGFGIDHDILQASCKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus JH9] Sequence ID: A5IUK3.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus JH1] Sequence ID: A6U3E2.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus Mu3] Sequence ID: A7X4N1.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus Mu50] Sequence ID: P63476.1 Length: 509 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus N315] Sequence ID: P63477.1 Length: 509 Range 1: 1 to 491 Score:154 bits(388), Expect:8e-40, Method:Compositional matrix adjust., Identities:138/513(27%), Positives:243/513(47%), Gaps:36/513(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + + ++I D TLRDGEQT GV+F+ E+L IA L+K VD +E S G ++VQ Sbjct 1 MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIA-LQLEKWGVDVIEAGFPASSTGSFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGK 118 I + T + G K+ +D + KD+ V+++ S HLE +L Sbjct 60 AIAQTLTT------TAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ + + YA + + ED + R ++ V+ I +PD Sbjct 114 SQEDVLASIKEHVTYAKQLFDVVQFSPEDAT---RTELPFLVKCVQTAVDAGATVINIPD 170 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +E F+ + + +I + H H+D ++V+NSL AI G + + ++N Sbjct 171 TVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVN 230 Query 236 GLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + ++ D ++T +N + S L+ ++G R+ N+ IVG+ Sbjct 231 GIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQ 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F+ +G+H DG K + P+ G + LGKL+GK + SE +K LG + + Sbjct 291 NAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYNIDK 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII--ADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 + ++ + D+ K V+ D+ II ++ + K+ T++ + S G++ Sbjct 351 EAQIDLFKQFKTIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSS--GLQSAV 408 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + + +G I+++ S G G A NA+ +I + +LIDY + G TDA E Sbjct 409 VVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKE----TELIDYRINSVTEG-TDAQAE 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHA 502 + L E +T G+ D A+ A Sbjct 464 VHVNL-----LIEGKTVNGFGIDHDILQASCKA 491 >RecName: Full=2-isopropylmalate synthase 2, chloroplastic; AltName: Full=2-isopropylmalate synthase 1; AltName: Full=Methylthioalkylmalate synthase-like 3; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q9C550.1 Length: 631 Range 1: 87 to 610 Score:155 bits(392), Expect:1e-39, Method:Compositional matrix adjust., Identities:149/534(28%), Positives:240/534(44%), Gaps:40/534(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ+ G + ++ EKL+IA+ L KL VD +E SK + E V+ I E Sbjct 87 VRIFDTTLRDGEQSPGATLTSKEKLDIAR-QLAKLGVDIIEAGFPAASKDDFEAVKTIAE 145 Query 68 WAA--TEQLTERIEILGFVDGNKT---VDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 ++ I G NK W +K + ++ S HL+ +L K+ Sbjct 146 TVGNTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKKSK 205 Query 121 KEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 +E ++ +A G + + ED R+ +Y+ ++ + K + +PDT Sbjct 206 EEVIEIARNMVRFARSLGCEDVEFSPEDAG---RSEREYLYEILGEVIKAGATTLNIPDT 262 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G+ P E Q + + P I H ND LS AN+L +G + + +ING Sbjct 263 VGITLPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTING 322 Query 237 LGERAGNTPLEALVTTIHDKSNSK-----TNINEIAITEASRLVEVFSGKRISANRPIVG 291 +GERAGN LE +V I + + T I+ I S++VE ++G + ++ IVG Sbjct 323 IGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVG 382 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLGM 347 + F +G+H DG K + PE G +RS LGKL+G+ ++ + + +LG Sbjct 383 ANAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKDRLNELGY 442 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSG-IGIR 406 VL + L + R + +Q K VT DL +++D + E V + I G +G+ Sbjct 443 VLDDGQLSNLFWRFKAVAEQKKRVTDADLIALVSDEVFQP-EAVWKLLDMQITCGTLGLS 501 Query 407 PHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDA 466 + GK H S G G DA A+ I L++Y + G DA Sbjct 502 TSTVKLADSDGKEHVACSVGTGPVDAAYKAVDLIVKEPAT----LLEYSMNAVTEG-IDA 556 Query 467 LVETRI---------TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 + TR+ + N ++TF G D V++V A LN++L Sbjct 557 IATTRVLIRGDNNYSSTNAVTGESVERTFSGTGAGMDIVVSSVKAYVGALNKML 610 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus mycoides KBAB4] Sequence ID: A9VLG7.1 Length: 506 Range 1: 6 to 465 Score:153 bits(387), Expect:1e-39, Method:Compositional matrix adjust., Identities:129/476(27%), Positives:226/476(47%), Gaps:29/476(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI---M 66 +D TLRDGEQ+ GV+ + EKL IA+ L++L ++ +E A S+G+ ++V++I + Sbjct 6 FMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGINVMEAGFAAASEGDFQSVKRIANTI 64 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A L E D + + +K + + L++ S H++ +L + ++ Sbjct 65 QNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDS 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + + ED + R S ++ VE + I +PDT+G +PE Sbjct 121 IHRSVTLGKSLFPTVQFSAEDAT---RTSRAFLAEAVEVAIRAGANVINIPDTVGYTNPE 177 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + L + P F H H+D ++VANSL A+ G + +ING+GERAGN Sbjct 178 EYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGN 237 Query 244 TPLEALVTTIHDK-----SNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 LE + +H + + S + EI T S LV +G + N+ IVG + F Sbjct 238 AALEEVAVALHIRKDFYEAESSMTLKEIKAT--STLVSRLTGMVVPKNKAIVGANAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K I P G ++ + LGK +G+ + +E +K+LG ++ V Sbjct 296 SGIHQDGVLKEVTTYEIIEPSLIGESQNLFVLGKHSGRHAFTEKMKELGYEFTKEERDVV 355 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQ 416 E L D+ K +T EDL ++ + ++ +I +H A + L + + Sbjct 356 FEAFKNLADRKKEITEEDLRALMLGEAAFAAQQ-YSITQLQVHFVSNSTQCATVVLKDEE 414 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G ++++ + G G +A NA+ +I LG+ L DY ++ G+ DAL + Sbjct 415 GNMYEDAATGSGSIEAIYNAIQRI---LGLECD-LADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=Homocitrate synthase [Azotobacter vinelandii] Sequence ID: P05342.2 Length: 385 Range 1: 6 to 360 Score:150 bits(380), Expect:1e-39, Method:Compositional matrix adjust., Identities:107/367(29%), Positives:179/367(48%), Gaps:14/367(3%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ+ GV+F+ EK+ IA+ L +L V +EI + + E E + I Sbjct 6 IDDTTLRDGEQSAGVAFNADEKIAIAR-ALAELGVPELEIGIPSMGEEEREVMHAIAGLG 64 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 + +L + + + + +G +++L S L +L + +V+ Sbjct 65 LSSRLLAWCRLC-----DVDLAAARSTGVTMVDLSLPVSDLMLHHKLNRDRDWALREVAR 119 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 ++ A +GL++ + ED S R ++V + E R+ DT+GV+ P F Sbjct 120 LVGEARMAGLEVCLGCEDAS---RADLEFVVQVGEVAQAAGARRLRFADTVGVMEP---F 173 Query 190 QGVDSL--IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 +D + + D+ E H H+D+ L+ AN+L A+ G ++ ++NGLGERAGN LE Sbjct 174 GMLDRFRFLSRRLDMELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAGNAALE 233 Query 248 ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDK 307 V + + T I+ I S LVE SG++++ + +VG VFT AG+H DG Sbjct 234 ECVLALKNLHGIDTGIDTRGIPAISALVERASGRQVAWQKSVVGAGVFTHEAGIHVDGLL 293 Query 308 KGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQ 367 K + P+ GR S LGK +G + + LG+ L++ Q +L R+ + Sbjct 294 KHRRNYEGLNPDELGRSHSLVLGKHSGAHMVRNTYRDLGIELADWQSQALLGRIRAFSTR 353 Query 368 NKLVTPE 374 K +P+ Sbjct 354 TKRRSPQ 360 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella baltica OS185] Sequence ID: A6WIB5.1 Length: 522 Range 1: 1 to 498 Score:154 bits(388), Expect:1e-39, Method:Compositional matrix adjust., Identities:142/525(27%), Positives:238/525(45%), Gaps:47/525(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE I Sbjct 111 LKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAILAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGNIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE + + + +T IN I S LV + AN+ I Sbjct 228 TINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFII-----ADVSGRTGEKVLTIKSCNIHSGI 403 + + + E ++L D+ V DL + A+ + L ++S S Sbjct 348 EHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQS---DSTE 404 Query 404 GIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK 463 G+ A + +E G+I E + G+G DA NA+ + T+R +I Y++ G+ Sbjct 405 GVAT-ATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGVGQ 459 Query 464 TDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 +AL + IT + +Q F +G+ D A+ A ++N Sbjct 460 -NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella baltica OS155] Sequence ID: A3CZK5.1 Length: 522 Range 1: 1 to 498 Score:153 bits(387), Expect:1e-39, Method:Compositional matrix adjust., Identities:141/525(27%), Positives:238/525(45%), Gaps:47/525(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE I Sbjct 111 LKRSFDQVLEMAVSAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAILAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGTIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE + + + +T IN I S LV + AN+ I Sbjct 228 TINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFII-----ADVSGRTGEKVLTIKSCNIHSGI 403 + + + E ++L D+ V DL + A+ + L ++S + G+ Sbjct 348 EHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQS-DSTEGV 406 Query 404 GIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK 463 A + +E G+I E + G+G DA NA+ + T+R +I Y++ G+ Sbjct 407 AT---ATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGVGQ 459 Query 464 TDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 +AL + IT + +Q F +G+ D A+ A ++N Sbjct 460 -NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella sp. W3-18-1] Sequence ID: A1REY0.1 Length: 522 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella putrefaciens CN-32] Sequence ID: A4Y2M0.1 Length: 522 Range 1: 1 to 498 Score:153 bits(387), Expect:1e-39, Method:Compositional matrix adjust., Identities:141/525(27%), Positives:238/525(45%), Gaps:47/525(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE I Sbjct 111 LKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAILAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGNIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE + + + +T IN I S LV + AN+ I Sbjct 228 TINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFII-----ADVSGRTGEKVLTIKSCNIHSGI 403 + + + E ++L D+ V DL + A+ + L ++S + G+ Sbjct 348 EHDYNMDTLYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQS-DSTEGV 406 Query 404 GIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK 463 A + +E G+I E + G+G DA NA+ + T+R +I Y++ G+ Sbjct 407 AT---ATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGVGQ 459 Query 464 TDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 +AL + IT + +Q F +G+ D A+ A ++N Sbjct 460 -NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Photobacterium profundum SS9] Sequence ID: Q6LV24.1 Length: 514 Range 1: 7 to 439 Score:153 bits(387), Expect:1e-39, Method:Compositional matrix adjust., Identities:124/443(28%), Positives:206/443(46%), Gaps:21/443(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA + L++L VD +E S G+ E+VQ I + Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-YALERLGVDVIEAGFPISSPGDFESVQTIAKHI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + + +K + A ++ S H++ +L ++ + Sbjct 66 KNSRVCALSRAVA-KDIDVAAESLKVAEAFRIHTFISTSTIHVQDKLRRSYDD------- 117 Query 130 VIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 VIE AI + + Y +D + R D + +VE I +PDT+G P Sbjct 118 VIEMAIAAVKRARNYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTLP 177 Query 186 EETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E V L + P+I H H+D +SVANS+ A++AG + + +INGLGERAG Sbjct 178 SEFGGIVAQLFNRVPNIDKAIISVHCHDDLGMSVANSMAAVQAGARQVEGTINGLGERAG 237 Query 243 NTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE + I +S+ +TNI I S++V I AN+ IVG + F ++ Sbjct 238 NCSLEEIAMIIKTRSDFLGVETNIKHEEIHRTSKMVSQLCNMPIQANKAIVGANAFNHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G K ++ L +G+A++ ++ LG + + L + Sbjct 298 GIHQDGMIKNKNTYEIMTPESIGLKSQALNLTSRSGRAAVKNHMDTLGYIDGDYNLDTLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 ++L D+ V DL ++ + R + + ++ SG I I+L+ + Sbjct 358 ADFLKLADRKGQVFDYDLEALMYFANLRDEDDFFKLNYLSVQSG-SIMATTSIKLQCGDE 416 Query 419 IHKEISEGDGGYDAFMNALTKIT 441 E + G+G DA + ++T Sbjct 417 EKCEAAVGNGPVDALYQCIYRLT 439 >PUTATIVE PSEUDOGENE: RecName: Full=Putative 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola str. Bp (Baizongia pistaciae)] Sequence ID: Q89A49.1 Length: 390 Range 1: 4 to 380 Score:150 bits(380), Expect:2e-39, Method:Compositional matrix adjust., Identities:113/394(29%), Positives:189/394(47%), Gaps:36/394(9%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ+ +S S +KL IA F L+KL VD +E S G+ E+V+KI Sbjct 4 KIIIFDTTLRDGEQSLKMSLSVKKKLKIA-FALEKLGVDVIEAGFPISSPGDFESVKKI- 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 +ERI+ + +D D AK + +H H++ +L K Sbjct 62 --------SERIKDAKICSLARCIDGDIDIAAKAMKKANSFRIHIFLGTSALHVQSKLKK 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERI 174 T + +I+ + S + Y +D + R S D + ++E ++ I Sbjct 114 TFDQ-------IIDMMVSSVKRAQKYTDDVEFSCEDAGRTSLDDLCRIIELAIDLGVKTI 166 Query 175 FLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLH 231 +PDT+G P E + S+ +K P+I H H+D ++VANS+ AI+ G + + Sbjct 167 NIPDTVGYTIPYEFSNIISSIYKKVPNIDKAIISVHCHDDLGMAVANSISAIQVGARQIE 226 Query 232 ASINGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRP 288 +I G+GERAGN LE ++ I D N KTNI I R++ + N+ Sbjct 227 GTITGVGERAGNAALEEILMAIKIRKDILNFKTNIKYQEIYSTCRVISSICNIPVPVNKA 286 Query 289 IVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGM 347 I+G + F+ ++G+H DG K I+PE G + L +G+A++ +K++G Sbjct 287 IIGSNAFSHSSGIHQDGILKDKKTYEIIVPESIGFVSQPLNLTSRSGRAAVKYRMKKIGY 346 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIA 381 S+ + + R ++L D+ V+ DL ++ Sbjct 347 KDSDYNIDILYSRFLKLADKKGRVSDSDLKQLVC 380 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus cereus E33L] Sequence ID: Q63DX8.1 Length: 506 Range 1: 3 to 465 Score:153 bits(386), Expect:2e-39, Method:Compositional matrix adjust., Identities:129/479(27%), Positives:226/479(47%), Gaps:29/479(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 ++ +D TLRDGEQ+ GV+ + EKL IA+ L++L + +E A S+G+ ++V++I Sbjct 3 KILFMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGIHVMEAGFAAASEGDFQSVKRIA 61 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ A L E D + + +K + + L++ S H++ +L + ++ Sbjct 62 NTIQNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDV 117 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + + + ED + R + D++ VE + I +PDT+G Sbjct 118 LDSIYRSVTLGKSLFPTVQFSAEDAT---RTARDFLAEAVEVAIRAGANVINIPDTVGYT 174 Query 184 SPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 +PEE + L + P F H H+D ++VANSL A+ G + +ING+GER Sbjct 175 NPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGER 234 Query 241 AGNTPLEALVTTIH-----DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 AGN LE + +H K+ + EI T S LV +G + N+ IVG + F Sbjct 235 AGNAALEEVAVALHIRKDFYKAEPSMTLKEIKAT--STLVSRLTGMVVPKNKAIVGANAF 292 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVL 354 +G+H DG K I P G ++ + LGK +G+ + +E +K+LG + Sbjct 293 AHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDER 352 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL- 413 V E +L D+ K +T EDL ++ + ++ I +H A + L Sbjct 353 DAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQ-YNITQLQVHFVSNSTQCATVVLK 411 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + +G + ++ + G G +A NA+ +I LG+ +L DY ++ G+ DAL + Sbjct 412 DEEGNVFEDAATGSGSIEAIYNAIQRI---LGLEC-ELADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [[Bacillus thuringiensis] serovar konkukian str. 97-27] Sequence ID: Q6HLF3.1 Length: 506 Range 1: 6 to 465 Score:153 bits(386), Expect:2e-39, Method:Compositional matrix adjust., Identities:127/474(27%), Positives:224/474(47%), Gaps:25/474(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI---M 66 +D TLRDGEQ+ GV+ + EKL IA+ L++L + +E A S+G+ ++V++I + Sbjct 6 FMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGIHVMEAGFAAASEGDFQSVKRIANTI 64 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A L E D + + +K + + L++ S H++ +L + ++ Sbjct 65 QNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDS 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + + ED + R + D++ +E + I +PDT+G +PE Sbjct 121 IHRSVTLGKSLFPTVQFSAEDAT---RTARDFLAEAIEVAIRAGANVINIPDTVGYTNPE 177 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + L + P F H H+D ++VANSL A+ G + +ING+GERAGN Sbjct 178 EYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGN 237 Query 244 TPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE + +H D ++ +I I S LV +G + N+ IVG + F +G Sbjct 238 AALEEVAVALHIRKDFYKAEPSITLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESG 297 Query 301 VHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K I P G ++ + LGK +G+ + +E +K+LG + V E Sbjct 298 IHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFE 357 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQGK 418 +L D+ K +T EDL ++ + ++ I +H A + L + +G Sbjct 358 AFKKLADRKKEITEEDLRALMLGEAAFAAQQ-YNITQLQVHFVSNSTQCATVVLKDEEGN 416 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + ++ + G G +A NA+ +I LG+ +L DY ++ G+ DAL + Sbjct 417 VFEDAATGSGSIEAIYNAIQRI---LGLEC-ELADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus cereus 03BB102] Sequence ID: C1EMA9.1 Length: 506 Range 1: 6 to 465 Score:153 bits(386), Expect:2e-39, Method:Compositional matrix adjust., Identities:129/476(27%), Positives:224/476(47%), Gaps:29/476(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI---M 66 +D TLRDGEQ+ GV+ + EKL IA+ L++L + +E A S+G+ ++V++I + Sbjct 6 FMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGIHVMEAGFAAASEGDFQSVKRIANTI 64 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A L E D + + +K + + L++ S H++ +L + ++ Sbjct 65 QNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDS 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + + ED + R + D++ VE + I +PDT+G +PE Sbjct 121 IYRSVTLGKSLFPTVQFSAEDAT---RTARDFLAEAVEVAIRAGANVINIPDTVGYTNPE 177 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + L + P F H H+D ++VANSL A+ G + +ING+GERAGN Sbjct 178 EYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGN 237 Query 244 TPLEALVTTIH-----DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 LE + +H K+ + EI T S LV +G + N+ IVG + F Sbjct 238 AALEEVAVALHIRKDFYKAEPSMTLKEIKAT--STLVSRLTGMVVPKNKAIVGANAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K I P G ++ + LGK +G+ + +E +K+LG + V Sbjct 296 SGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAV 355 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQ 416 E +L D+ K +T EDL ++ + ++ I +H A + L + + Sbjct 356 FEAFKKLADRKKEITEEDLRALMLGEAAFAAQQ-YNITQLQVHFVSNSTQCATVVLKDEE 414 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G + ++ + G G +A NA+ +I LG+ +L DY ++ G+ DAL + Sbjct 415 GNVFEDAATGSGSIEAIYNAIQRI---LGLEC-ELADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xylella fastidiosa M23] Sequence ID: B2I596.1 Length: 519 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xylella fastidiosa Temecula1] Sequence ID: Q87CL8.1 Length: 519 Range 1: 12 to 444 Score:153 bits(386), Expect:2e-39, Method:Compositional matrix adjust., Identities:127/450(28%), Positives:214/450(47%), Gaps:33/450(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ+ G S +KL +A+ L L VD +E S+ + E M Sbjct 12 IRIFDTTLRDGEQSPGCSMPAQQKLVMAR-ALDALGVDIIETGFPASSQSDYEA----MT 66 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKT 119 A E + +L ++ + ++ A+ L TK LH H E +L + Sbjct 67 LIARELRRPTLAVL-----SRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMS 121 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 ++ V + + + ED + R D++ + I LPDT Sbjct 122 KEQVLESVHKHVSLSRTLIDDVEFSAEDAT---RTEEDFLIEVTRVAIAAGATTINLPDT 178 Query 180 LGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G +PEE F V + ++ + F H H+D L+VANSL AI G + + +ING Sbjct 179 VGFSTPEEIRNMFTRVIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTING 238 Query 237 LGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 +GERAGN LE L + ++ N T+I+ I S+L++ G + N+ +VG + Sbjct 239 IGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGAN 298 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFGRKRSY-ALGKLAGKASISENVKQLGMVLSEV 352 F +G+H G + + P+ G S+ LG+ +G+A++ + ++ LG +L E Sbjct 299 AFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEE 358 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 L+ V E +L ++ +LVT DL ++ D + + G ++ ++ S +G R +A +E Sbjct 359 DLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTI----SDVGNRANALVE 414 Query 413 L-EYQGKIHKEISEGDGGYDAFMNALTKIT 441 L + QG+ E ++G+G DA AL T Sbjct 415 LSDPQGQRVAETAQGNGPVDALFGALAAAT 444 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Stenotrophomonas maltophilia K279a] Sequence ID: B2FT78.1 Length: 528 Range 1: 1 to 449 Score:153 bits(386), Expect:2e-39, Method:Compositional matrix adjust., Identities:134/464(29%), Positives:215/464(46%), Gaps:38/464(8%) Query 1 MTKVE----TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSK 56 MT +E R+ I D TLRDGEQ+ G S S +KL +A+ L +L VD +E S+ Sbjct 1 MTTIERITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMAR-ALDELGVDIIETGFPASSQ 59 Query 57 GELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH------ 110 + E + I L+ + +L ++ + ++ A+ L LH Sbjct 60 SDREAMALIGRELRRPSLS--LAVL-----SRCLQADIETSARALEAAANPRLHVFLSTS 112 Query 111 --HLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSK 168 H E +L T ++ V + A + ED + R DY+ + Sbjct 113 PLHREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDAT---RTELDYLIEVARVAIA 169 Query 169 EHIERIFLPDTLGVLSPEE---TFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQA 222 I LPDT+G +PEE FQ V + + P+ + F H HND L+VANSL A Sbjct 170 AGATTINLPDTVGFTTPEEIRAMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAA 229 Query 223 IRAGVKGLHASINGLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFS 279 I G + + ++NG+GERAGN LE + + + ++IN I S+L++ Sbjct 230 IEGGARQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLV 289 Query 280 GKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASI 338 G + N+ IVG + F +G+H G + + PE G + S LG+ +G+A++ Sbjct 290 GMPVQRNKAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAV 349 Query 339 SENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCN 398 ++ LG L E L+ V E+ L +Q ++VT DL ++ S G ++ ++ Sbjct 350 EARLRALGFWLDEDELKLVFEQFKGLCEQQRVVTDADLQTLMQGGSNAQGYRLASMTI-- 407 Query 399 IHSGIGIRPHAQIEL-EYQGKIHKEISEGDGGYDAFMNALTKIT 441 S +G R +A +EL + G E ++GDG DA AL+ T Sbjct 408 --SDVGSRANALVELSDPDGNRVAETAQGDGPVDALFGALSAAT 449 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus cereus AH820] Sequence ID: B7JFY5.1 Length: 506 Range 1: 6 to 465 Score:152 bits(385), Expect:2e-39, Method:Compositional matrix adjust., Identities:129/476(27%), Positives:225/476(47%), Gaps:29/476(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI---M 66 +D TLRDGEQ+ GV+ + EKL IA+ L++L + +E A S+G+ ++V++I + Sbjct 6 FMDTTLRDGEQSPGVNLNEQEKLQIAR-QLERLGIHVMEAGFAAASEGDFQSVKRIANTI 64 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + A L E D + + +K + + L++ S H++ +L + ++ Sbjct 65 QNATVMSLARAKE----SDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDS 120 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + + + ED + R + D++ VE + I +PDT+G +PE Sbjct 121 IYRSVTLGKSLFPTVQFSAEDAT---RTARDFLAEAVEVAIRAGANVINIPDTVGYTNPE 177 Query 187 ET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E F+ + + Y F H H+D ++VANSL A+ G + +ING+GERAGN Sbjct 178 EYYALFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGN 237 Query 244 TPLEALVTTIH-----DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQT 298 LE + +H K+ + EI T S LV +G + N+ IVG + F Sbjct 238 AALEEVAVALHIRKDFYKAEPSMTLKEIKAT--STLVSRLTGMVVPKNKAIVGANAFAHE 295 Query 299 AGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H DG K I P G ++ + LGK +G+ + +E +K+LG + V Sbjct 296 SGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAV 355 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQ 416 E +L D+ K +T EDL ++ + ++ I +H A + L + + Sbjct 356 FEAFKKLADRKKEITEEDLRALMLGEAAFAAQQ-YNITQLQVHFVSNSTQCATVVLKDEE 414 Query 417 GKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G + ++ + G G +A NA+ +I LG+ +L DY ++ G+ DAL + Sbjct 415 GNVFEDAATGSGSIEAIYNAIQRI---LGLEC-ELADYRIQSITQGQ-DALAHVHV 465 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus RF122] Sequence ID: Q2YUF2.1 Length: 509 Range 1: 1 to 491 Score:152 bits(385), Expect:2e-39, Method:Compositional matrix adjust., Identities:138/513(27%), Positives:242/513(47%), Gaps:36/513(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + + ++I D TLRDGEQT GV+F+ E+L IA L+K VD +E S G ++VQ Sbjct 1 MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIA-LQLEKWGVDVIEAGFPASSTGSFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGK 118 I + T + G K+ +D + KD+ V+++ S HLE +L Sbjct 60 AIAQTLTT------TAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ + + YA + + ED + R ++ V+ I +PD Sbjct 114 SQEDVLASIKEHVTYAKQLFDVVQFSPEDAT---RTELPFLVKCVQTAVDAGATVINIPD 170 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +E F+ + +I + H H+D ++V+NSL AI G + + ++N Sbjct 171 TVGYSYHDEYAHIFKTLTESATSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVN 230 Query 236 GLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + ++ D ++T +N + S L+ ++G R+ N+ IVG+ Sbjct 231 GIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQ 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F+ +G+H DG K + P+ G + LGKL+GK + SE +K LG + + Sbjct 291 NAFSHESGIHQDGVLKHRETYEIMTPQLVGVSMTELPLGKLSGKHAFSEKLKALGYDIDK 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII--ADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 + ++ + D+ K V+ D+ II ++ + K+ T++ + S G++ Sbjct 351 EAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSS--GLQSAV 408 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + + +G I+++ S G G A NA+ +I + +LIDY + G TDA E Sbjct 409 VVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKE----TELIDYRINSVTEG-TDAQAE 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHA 502 + L E +T G+ D A+ A Sbjct 464 VHVNL-----LIEGKTVNGFGIDHDILQASCKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella frigidimarina NCIMB 400] Sequence ID: Q07WG9.1 Length: 522 Range 1: 1 to 506 Score:152 bits(385), Expect:3e-39, Method:Compositional matrix adjust., Identities:136/532(26%), Positives:241/532(45%), Gaps:45/532(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ ++VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLTVKEKLQIA-LALERLGVDVMEVGFPVSSPGDFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I + ++ ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TIAKTIKNSRVCAL---------SRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE K I Sbjct 111 LKRSFDDVLEMAVNAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEEAIKAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A+ G + + Sbjct 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSIAAVEMGARQVEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE + + + + IN I S LV I AN+ I Sbjct 228 TINGIGERAGNCSLEEIAMILATRKGLLDLDCGINAKEIHRTSSLVSQLCNMPIQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + F+ ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGTNAFSHSSGIHQDGMLKAKNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYK 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHS----GIG 404 ++ + + E+ + L D+ V DL ++ S + ++ +HS G+ Sbjct 348 PTDYDMDSLYEQFLTLADKKGQVFDYDLEALVFMESQAQDDDKYQLQHMMVHSDSTEGVA 407 Query 405 IRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKT 464 A + + GK E + G+G DA NA+ + T+R I+I +Y++ G+ Sbjct 408 T---ATVRIAVDGKDITEAATGNGPVDAAYNAIARATDR-KINIT---NYKLSAKGEGQ- 459 Query 465 DALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 +AL + IT + +Q F +G+ D A+ A ++N + + ++ Sbjct 460 NALGQVDITAKYN-----EQMFHGVGLATDVVEASAQALVHVMNLVYRADKV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella woodyi ATCC 51908] Sequence ID: B1KKZ4.1 Length: 523 Range 1: 4 to 498 Score:152 bits(385), Expect:3e-39, Method:Compositional matrix adjust., Identities:137/518(26%), Positives:239/518(46%), Gaps:39/518(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ ++V+ I Sbjct 4 RVIIFDTTLRDGEQALAASLTVKEKLQIA-LSLERLGVDVMEVGFPVSSPGDFKSVETI- 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 A R+ L + ++ D+ A+ L++ + +H H+E +L + Sbjct 62 ---ARTVKNSRVCALA-----RALEKDIDAAAQSLSVADQFRIHTFISTSTIHVESKLKR 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + + ++YA + + ED R D + +VE K + I +PD Sbjct 114 SFDQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEEAIKAGAKTINIPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E +++L + P+I H H+D LSVANS+ A++ G + + ++N Sbjct 171 TVGYTVPSEFGGIIETLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQQGARQIECTVN 230 Query 236 GLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + + + + +T IN I S LV + AN+ IVG Sbjct 231 GIGERAGNCSLEEIAMILSTRKAALGLETGINAKEIHRTSSLVSQLCNMPVQANKAIVGA 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSE 351 + FT ++G+H DG K + PE G R + + +G+ I ++++G + Sbjct 291 NAFTHSSGIHQDGMLKSQNTYEIMTPESIGLPRNNLNMTSRSGRHVIKHRMEEMGYGEHD 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHS-GIGIRPHAQ 410 + + E ++L D+ V DL + + E +K +HS A Sbjct 351 YDMDVLYESFLKLADKKGQVFDYDLEALTFMEAQAEEESFYQLKQLVVHSDSTQGNATAT 410 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 +++E G++ E + G+G DA NA+ + ++ I+I Y++ G+ DAL + Sbjct 411 VKIELDGEVVTEAATGNGPVDAAYNAIAR-ASKCEINITS---YKLSAKGEGQ-DALGQV 465 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 I + + Q+F +G+ D A+V A ++N Sbjct 466 DIEASY-----QQQSFHGVGLATDVVEASVQALIHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella baltica OS223] Sequence ID: B8E4K4.1 Length: 522 Range 1: 1 to 498 Score:152 bits(384), Expect:3e-39, Method:Compositional matrix adjust., Identities:141/525(27%), Positives:238/525(45%), Gaps:47/525(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE I Sbjct 111 LKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAILVGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGTIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE + + + +T IN I S LV + AN+ I Sbjct 228 TINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFII-----ADVSGRTGEKVLTIKSCNIHSGI 403 + + + E ++L D+ V DL + A+ + L ++S + G+ Sbjct 348 EHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQS-DSTEGV 406 Query 404 GIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK 463 A + +E G+I E + G+G DA NA+ + T+R +I Y++ G+ Sbjct 407 AT---ATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGVGQ 459 Query 464 TDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 +AL + IT + +Q F +G+ D A+ A ++N Sbjct 460 -NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus aureus subsp. aureus MRSA252] Sequence ID: Q6GF16.1 Length: 509 Range 1: 1 to 491 Score:152 bits(384), Expect:4e-39, Method:Compositional matrix adjust., Identities:137/513(27%), Positives:243/513(47%), Gaps:36/513(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + + ++I D TLRDGEQT GV+F+ E+L IA L+K VD +E S G ++VQ Sbjct 1 MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIA-LQLEKWGVDVIEAGFPASSTGSFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKT-VDWI----KDSGAKVLNLLTKGSLHHLEKQLGK 118 I + T + G K+ +D + KD+ V+++ S HLE +L Sbjct 60 AIAQTLTT------TAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKM 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ + + YA + + ED + R ++ V+ I +PD Sbjct 114 SQEDVLASIKEHVTYAKQLFDVVQFSPEDAT---RTELPFLVKCVQTAVDAGATVINIPD 170 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +E F+ + + +I + H H+D ++V+NSL AI G + + ++N Sbjct 171 TVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVN 230 Query 236 GLGERAGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + ++ D ++T +N + S L+ ++G R+ N+ IVG+ Sbjct 231 GIGERAGNAALEEVALALYIRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQ 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F+ +G+H DG K + P+ G + LGKL+GK + S+ +K LG + + Sbjct 291 NAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSKKLKALGYDIDK 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII--ADVSGRTGEKVLTIKSCNIHSGIGIRPHA 409 + ++ + D+ K V+ D+ II ++ + K+ T++ + S G++ Sbjct 351 EAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSS--GLQSAV 408 Query 410 QIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 + + +G I+++ S G G A NA+ +I + +LIDY + G TDA E Sbjct 409 VVIKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKE----TELIDYRINSVTEG-TDAQAE 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHA 502 + L E +T G+ D A+ A Sbjct 464 VHVNL-----LIEGKTVNGFGIDHDILQASCKA 491 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella baltica OS195] Sequence ID: A9KY13.1 Length: 522 Range 1: 1 to 498 Score:152 bits(384), Expect:4e-39, Method:Compositional matrix adjust., Identities:140/525(27%), Positives:238/525(45%), Gaps:47/525(8%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLSVKEKLQIA-MALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----ARTIKNSRVCAL-----SRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R + + +VE I Sbjct 111 LKRSFDQVLEMAVSAVKYARRFTDDVEFSCEDAG---RTPIENLCRMVEAAILAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGNIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE + + + +T IN I S LV + AN+ I Sbjct 228 TINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I ++++G Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYS 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFII-----ADVSGRTGEKVLTIKSCNIHSGI 403 + + + E ++L D+ V DL + A+ + L ++S + G+ Sbjct 348 EHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQS-DSTEGV 406 Query 404 GIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK 463 A + +E G+I E + G+G DA NA+ + T+R +I Y++ G+ Sbjct 407 AT---ATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRR----IDIISYKLGAKGVGQ 459 Query 464 TDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 +AL + IT + +Q F +G+ D A+ A ++N Sbjct 460 -NALGQVDITA-----VYHEQNFHGVGLATDVVEASARALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292] Sequence ID: Q49Z12.1 Length: 511 Range 1: 1 to 466 Score:152 bits(383), Expect:5e-39, Method:Compositional matrix adjust., Identities:130/478(27%), Positives:228/478(47%), Gaps:21/478(4%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + + ++I D TLRDGEQT GV+FS E+L IAK L+K VD +E S G ++V+ Sbjct 1 MSSHIQIFDTTLRDGEQTPGVNFSFDERLKIAK-QLEKWGVDIIEAGFPASSSGSFKSVE 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 I + T + + D + + K + +++ S H + +L + +E Sbjct 60 AIAKTLTTTAVCGLARCVK-KDIDAVYESTKAAAKPRIHVFIATSPIHRDSKLMMSKEEV 118 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + + YA + + ED + R ++ V+ I +PDT+G Sbjct 119 LASIKEHVSYAKQYFDVVQFSPEDAT---RTELPFLIECVQTAVDAGASVINIPDTVGFS 175 Query 184 SPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P+E F+ + + D+ + H H+D L+VANS+ AI G K + ++NG+GER Sbjct 176 YPKEYGEIFKTLQESVHADHDVIYSAHCHDDLGLAVANSMAAIENGAKRIEGTLNGIGER 235 Query 241 AGNTPLEALVTTIH---DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE + ++ D +++T IN + S L+ F+G R+ N+ IVG++ F+ Sbjct 236 AGNTALEEVALGLYVRQDHYDNQTQINLEETKQTSDLIARFAGIRVPRNKAIVGQNAFSH 295 Query 298 TAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQK 356 +G+H DG K + P+ G K + LGKL+GK + +E + LG + + Sbjct 296 ESGIHQDGVLKNPETYEIMTPQLVGVKTTELPLGKLSGKHAFAEKLTALGYDVDPEEQKT 355 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGE--KVLTIKSCNIHSGIGIRPHAQIELE 414 + ++ + D+ K VT D+ +I KV T++ + + G++ + + Sbjct 356 LFKQFKTVADKKKAVTDRDIHALIQGTEHEQNAIYKVETLQLQFVSN--GLQSAVVVIKD 413 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 G +++ S G G + NA+ +I +R +LI+Y + G TDA E + Sbjct 414 IDGNTYQDSSIGTGSIVSVYNAVDRIFDRK----TELIEYRIDSVTEG-TDAQAEVHV 466 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Stenotrophomonas maltophilia R551-3] Sequence ID: B4SI67.1 Length: 528 Range 1: 1 to 449 Score:152 bits(383), Expect:7e-39, Method:Compositional matrix adjust., Identities:133/464(29%), Positives:215/464(46%), Gaps:38/464(8%) Query 1 MTKVE----TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSK 56 MT +E R+ I D TLRDGEQ+ G S S +KL +A+ L +L VD +E S+ Sbjct 1 MTTIERITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMAR-ALDELGVDIIETGFPASSQ 59 Query 57 GELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH------ 110 + + + I L+ + +L ++ + ++ A+ L LH Sbjct 60 SDRDAMALIGRELRRPSLS--LAVL-----SRCLQADIETSARALEAAANPRLHVFLSTS 112 Query 111 --HLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSK 168 H E +L T ++ V + A + ED + R DY+ + Sbjct 113 PLHREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDAT---RTELDYLIEVSRAAIS 169 Query 169 EHIERIFLPDTLGVLSPEE---TFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQA 222 I LPDT+G +PEE FQ V + + P+ + F H HND L+VANSL A Sbjct 170 AGATTINLPDTVGFTTPEEIREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAA 229 Query 223 IRAGVKGLHASINGLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFS 279 I G + + ++NG+GERAGN LE + + + ++IN I S+L++ Sbjct 230 IEGGARQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLV 289 Query 280 GKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASI 338 G + N+ IVG + F +G+H G + + PE G + S LG+ +G+A++ Sbjct 290 GMPVQRNKAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAV 349 Query 339 SENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCN 398 ++ LG L E L+ V E+ L +Q ++VT DL ++ S G ++ ++ Sbjct 350 EARLRALGFWLEEDELKLVFEQFKGLCEQQRVVTDADLQTLMQGGSNAQGYRLASMTI-- 407 Query 399 IHSGIGIRPHAQIEL-EYQGKIHKEISEGDGGYDAFMNALTKIT 441 S +G R +A +EL + G E ++GDG DA AL+ T Sbjct 408 --SDVGSRANALVELSDPDGNRVAETAQGDGPVDALFGALSAAT 449 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Citrobacter koseri ATCC BAA-895] Sequence ID: A8ALM5.1 Length: 523 Range 1: 7 to 505 Score:150 bits(380), Expect:1e-38, Method:Compositional matrix adjust., Identities:144/518(28%), Positives:232/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVADAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R D + +VE + I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIDDLARVVEAAINAGAKTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L V N+L A+ AG + + ++NG+GERAG Sbjct 179 E-FGGIISGLYERVPNIDKAIISVHTHDDLGLGVGNALAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRQDILNVHTRINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L Sbjct 358 DAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSNDIATASVKLACGDD 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 I E + G+G DA A+ +IT+ +I +L+ Y + GK DAL + I N + Sbjct 418 IKAEAANGNGPVDAIYQAINRITD---YNI-ELVKYSLSAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Paratyphi C str. RKS4594] Sequence ID: C0Q5H1.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67] Sequence ID: Q57TE6.1 Length: 523 Range 1: 7 to 505 Score:150 bits(380), Expect:1e-38, Method:Compositional matrix adjust., Identities:139/515(27%), Positives:230/515(44%), Gaps:24/515(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +I+ A + ED R D + +VE I +PDT+G P E F Sbjct 125 MIKRARNYTDDVEFSCEDAG---RTPVDDLARVVEAAINAGARTINIPDTVGYTMPFE-F 180 Query 190 QGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 G+ S L ++ P+I H H+D ++V NSL A+ AG + + ++NG+GERAGN Sbjct 181 AGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCA 240 Query 246 LEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 LE ++ I D N TNIN I S+ V I AN+ IVG F ++G+H Sbjct 241 LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIH 300 Query 303 ADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 DG K + PE G + L +G+A++ ++++G ++ + + + Sbjct 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAF 360 Query 362 IELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHK 421 ++L D+ V DL + + + + ++ SG A ++L +I Sbjct 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKA 420 Query 422 EISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLE 481 E + G+G DA A+ +IT G + +L+ Y++ GK DAL + I N Sbjct 421 EAANGNGPVDAIYQAINRIT---GYDV-ELVKYDLNAKGQGK-DALGQVDIVVN-----H 470 Query 482 EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 471 HGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=Methylthioalkylmalate synthase 1, chloroplastic; AltName: Full=2-isopropylmalate synthase 3; Flags: Precursor [Arabidopsis thaliana] Sequence ID: Q9FG67.1 Length: 506 Range 1: 85 to 474 Score:150 bits(379), Expect:1e-38, Method:Compositional matrix adjust., Identities:118/394(30%), Positives:193/394(48%), Gaps:25/394(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + + D TLRDGEQ+ G S + +KL IA+ L KL VD +E+ S+ ELET++ I + Sbjct 85 VRVFDTTLRDGEQSPGGSLTPPQKLEIAR-QLAKLRVDIMEVGFPGSSEEELETIKTIAK 143 Query 68 WAATE--QLTERIEILGFVDGNKTVD----W--IKDSGAKVLNLLTKGSLHHLEKQLGKT 119 E + T + ++ + K D W +K + + + T S H++ +L KT Sbjct 144 TVGNEVDEETGYVPVICAIARCKHRDIEATWEALKYAKRPRILVFTSTSDIHMKYKLKKT 203 Query 120 PKEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 +E I +A G I ED G R+ D++ ++ K + + + D Sbjct 204 QEEVIEMAVSSIRFAKSLGFNDIQFGCED---GGRSDKDFLCKILGEAIKAGVTVVTIGD 260 Query 179 TLGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G+ P E + V L P D+ H HND L+ ANS+ IRAG + + +IN Sbjct 261 TVGINMPHEYGELVTYLKANTPGIDDVVVAVHCHNDLGLATANSIAGIRAGARQVEVTIN 320 Query 236 GLGERAGNTPLEALVTTIHDK-----SNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 G+GER+GN LE +V + + + T I+ I S++V+ ++G + A++PIV Sbjct 321 GIGERSGNASLEEVVMALKCRGAYVINGVYTKIDTRQIMATSKMVQEYTGLYVQAHKPIV 380 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLG 346 G + F +G+H DG K + PE G +S LGKL+G+ ++ + +K+LG Sbjct 381 GANCFVHESGIHQDGILKNRSTYEILSPEDIGIVKSQNSGLVLGKLSGRHAVKDRLKELG 440 Query 347 MVLSEVVLQKVLERVIELGDQNKLVTPEDLPFII 380 L + L V +L K +T DL ++ Sbjct 441 YELDDEKLNAVFSLFRDLTKNKKRITDADLKALV 474 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Uroleucon ambrosiae)] Sequence ID: Q9EVH0.1 Length: 503 Range 1: 1 to 493 Score:150 bits(379), Expect:2e-38, Method:Compositional matrix adjust., Identities:137/510(27%), Positives:232/510(45%), Gaps:27/510(5%) Query 17 DGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQLTE 76 DGEQ S S EKL IA L+K VD +E+ S G+ ++VQ I + ++ Sbjct 1 DGEQALQASLSVKEKLQIA-LCLEKSGVDIMEVGFPISSPGDFKSVQTISQKIKNSRVCS 59 Query 77 RIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSFVIEYAIK 136 + D + + + S + +++ S H+E +L K E F ++ A++ Sbjct 60 LARCIE-KDIDVAGEAMSASNSFRIHIFLATSTLHMESKLRKNFNEIIDMAIFSVKRALR 118 Query 137 SGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLI 196 I ED S R + D + +VE L ++ I +PDT+G P E + +L Sbjct 119 YTDDIEFSCEDAS---RTTIDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSFIIKNLF 175 Query 197 QKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTI 253 +K P+IH H H+D ++V NS+ AI+AG + + +ING+GERAGNT LE ++ I Sbjct 176 EKVPNIHKSTISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235 Query 254 ---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGN 310 D TNIN I S++V I +N+ IVG + F ++G+H DG K Sbjct 236 KVREDILGVSTNINHKEIYRTSQIVSSICNMPIPSNKAIVGSNAFAHSSGIHQDGVLKNR 295 Query 311 LYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNK 369 I P G K+ L +G+A++ + ++G ++ + ++ ++L D+ Sbjct 296 ENYEIIDPISIGLKKVKLNLTSRSGRAAVKHYMNEMGYKENDYNIDELYTDFLKLADKKG 355 Query 370 LVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEIS-EGDG 428 V DL + + + ++K ++ S A + L KI+ E S +G Sbjct 356 QVFDYDLEALAFINKQQDESEYFSLKFFSVQSISNNLSTASVTLLCGKKIYTEASTTSNG 415 Query 429 GYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRITWNKSLDLEEDQTF 486 DA AL +IT+ P ++ + G DAL V+ + + K + F Sbjct 416 PVDAIYQALNRITH-----FPIVLQKFQLVAKGKGKDALGQVDILVEYKK-------RKF 463 Query 487 KTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 +G+ D ++ A +LN I + Q+ Sbjct 464 HGVGLATDIMESSAKAMVNVLNNIWKAKQV 493 >RecName: Full=Homocitrate synthase [Pantoea agglomerans] Sequence ID: Q52070.1 Length: 400 Range 1: 20 to 375 Score:148 bits(373), Expect:2e-38, Method:Compositional matrix adjust., Identities:112/378(30%), Positives:179/378(47%), Gaps:34/378(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ------ 63 I D TLRDGEQ+ GV+F SEKL IA+ L+ N E+ + + GE E V+ Sbjct 20 INDTTLRDGEQSPGVAFRASEKLEIAQALV---NAGVRELEAGTPALGEEECVRLAILRR 76 Query 64 -----KIMEWAATEQLTERIEILGFVDGNKT-VDWIKDSGAKVLNLLTKGSLHHLEKQLG 117 +M W R+ D + +DW+ D +LL + LH Sbjct 77 QLPDTVMMSWC-------RMNSAEIHDSARVGMDWV-DISVPASDLLREQKLH------- 121 Query 118 KTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + + +++ A + G+++ + ED S R++ + + L E + IER+ Sbjct 122 RPWPAVIASLKPLVQLAHRLGMRVCMGCEDAS---RSADETLHMLAEVAADLGIERMRFA 178 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 DTLG+L P TF + +L Q + E H HND ++ AN+L A+RAG ++ ++ GL Sbjct 179 DTLGILDPFSTFTRISALRQHWHG-GLEIHAHNDLGMATANTLAAVRAGATHVNTTVLGL 237 Query 238 GERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 GERAGN LE++ ++ + I+ + RLV +G+ I P+VG VFT Sbjct 238 GERAGNAALESVTLSLDRCLHLDCGIDFTELPALCRLVAAAAGRTIDVQHPLVGGQVFTH 297 Query 298 TAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H + I P GR+ + LGK +G+ ++S +LG +LSE + Sbjct 298 ESGLHVAALLRDPRSYQGIDPSLVGREFNLVLGKHSGRQAVSGICARLGYILSETQTLLM 357 Query 358 LERVIELGDQNKLVTPED 375 L+ V + K ED Sbjct 358 LQEVKRFAEHFKRNPGED 375 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas citri subsp. citri 306] Sequence ID: P58900.1 Length: 520 Range 1: 11 to 444 Score:150 bits(379), Expect:2e-38, Method:Compositional matrix adjust., Identities:122/443(28%), Positives:208/443(46%), Gaps:17/443(3%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G S + +KL +A+ L +L VD +E S + E V + Sbjct 11 RIRIFDTTLRDGEQSPGCSMTPQQKLVMAR-ALDELGVDIIETGFPASSHSDREAVAMMG 69 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 L L D + ++ + L++ S H E +L + ++ Sbjct 70 RELRRPTLAVLSRCLQ-ADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLES 128 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 V + A + ED + R D++ + I LPDT+G +PE Sbjct 129 VHRHVTLARGYVDDVEFSAEDAT---RTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPE 185 Query 187 E---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E F + + ++ + F H HND L+VANSL AI G + + +ING+GERAGN Sbjct 186 EIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGN 245 Query 244 TPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE + + + N + IN I S+L++ G + N+ +VG + F +G Sbjct 246 CALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESG 305 Query 301 VHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H G + + PE G + S LG+ +G+A++ + ++ LG +L E ++ V E Sbjct 306 IHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEEEVKLVFE 365 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQGK 418 + L ++ ++VT DL ++ D + + G ++ ++ S +G R +A +EL + +G Sbjct 366 QFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTI----SDVGSRANALVELSDPEGN 421 Query 419 IHKEISEGDGGYDAFMNALTKIT 441 E ++G+G DA AL T Sbjct 422 RVAETAQGNGPVDALFGALASAT 444 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter jejuni subsp. jejuni 81116] Sequence ID: A8FP35.1 Length: 511 Range 1: 3 to 505 Score:150 bits(378), Expect:2e-38, Method:Compositional matrix adjust., Identities:140/525(27%), Positives:232/525(44%), Gaps:35/525(6%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + ++ I D TLRDGEQ G S ++KL IA L+ L VD +E S+G+ + VQK Sbjct 3 DNKIIIFDTTLRDGEQALGSSLGINQKLQIA-LALENLGVDVIEAGFPVSSQGDFKAVQK 61 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + +L D + + +K + ++ S H++ +L K Sbjct 62 IASKVKNSTICALSRVLD-KDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKK------ 114 Query 125 TDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 D ++ A ++ ++ Y +D + R D + +VE+ K + I +PDT+ Sbjct 115 -DFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTV 173 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G P E + L K P+I H HND ++ NSL AI G + + +INGL Sbjct 174 GYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 GERAGN LE +V I + + T+I I + S+LV + + I +++ IVG + Sbjct 234 GERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEV 352 F+ ++G+H DG K I P G + + +G+A I ++ LG + Sbjct 294 AFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTY 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 L V ER + L D+ V DL ++ E ++ ++ SG I P A + Sbjct 354 NLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENKFILEKLSVISG-NI-PTACVC 411 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + + ++ E G+G +A N + +ITN P L Y + G DA + + Sbjct 412 MRIKEELKTEACTGNGPVEAVFNCIARITNLK----PALKAYSINAKSSG-VDAQGQVDV 466 Query 473 TWNKSLDLE-EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 DLE + + F G+ D A+ A N I + ++ Sbjct 467 ------DLEFKGRKFHGKGISTDVIEASAQAFVSAYNAIYRSLKV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Paratyphi A str. AKU_12601] Sequence ID: B5BLB5.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150] Sequence ID: Q5PDG1.1 Length: 523 Range 1: 7 to 505 Score:150 bits(379), Expect:2e-38, Method:Compositional matrix adjust., Identities:142/523(27%), Positives:232/523(44%), Gaps:40/523(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A R+ L + V+ D A+ L + +H H+ +L T Sbjct 62 ARTIKNSRVCALA-----RCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLG 181 E ++++ A + ED R D + +VE I +PDT+G Sbjct 117 EVIERAVYMVKRARNYTDDVEFSCEDAG---RTPVDDLARVVEAAINAGARTINIPDTVG 173 Query 182 VLSPEETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 P E F G+ S L ++ P+I H H+D ++V NSL A+ AG + + ++NG+ Sbjct 174 YTMPFE-FAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGI 232 Query 238 GERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GERAGN LE ++ I D N TNIN I S+ V I AN+ IVG Sbjct 233 GERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGA 292 Query 295 FTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVV 353 F ++G+H DG K + PE G + L +G+A++ ++++G ++ Sbjct 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYN 352 Query 354 LQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL 413 + + + ++L D+ V DL + + + + ++ SG A ++L Sbjct 353 MDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKL 412 Query 414 EYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRIT 473 +I E + G+G DA A+ +IT G + +L+ Y++ GK DAL + I Sbjct 413 ACGEEIKAEAANGNGPVDAIYQAINRIT---GYDV-ELVKYDLNAKGQGK-DALGQVDIV 467 Query 474 WNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 N + F +G+ D ++ A +LN I + ++ Sbjct 468 VN-----HHGRRFHGVGLATDIVESSAKAMMHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas euvesicatoria pv. vesicatoria str. 85-10] Sequence ID: Q3BPJ9.1 Length: 520 Range 1: 11 to 444 Score:150 bits(378), Expect:2e-38, Method:Compositional matrix adjust., Identities:124/451(27%), Positives:211/451(46%), Gaps:33/451(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ+ G S + +KL +A+ L +L VD +E S + E V + Sbjct 11 RIRIFDTTLRDGEQSPGCSMTPQQKLVMAR-ALDELGVDIIETGFPASSHSDREAVAMM- 68 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 E + +L ++ + ++ AK L LH H E +L Sbjct 69 ---GRELRRPTLAVL-----SRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRM 120 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ V + A + ED + R D++ + I LPD Sbjct 121 SREQVLESVHRHVTLARGYIDDVEFSAEDAT---RTEEDFLAEVTRVAIAAGATTINLPD 177 Query 179 TLGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G +PEE F + + ++ + F H HND L+VANSL AI G + + +IN Sbjct 178 TVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTIN 237 Query 236 GLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + + + N + IN I S+L++ G + N+ +VG Sbjct 238 GIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGG 297 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSE 351 + F +G+H G + + PE G + S LG+ +G+A++ + ++ LG +L E Sbjct 298 NAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEE 357 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 ++ V E+ L ++ ++VT DL ++ D + + G ++ ++ S +G R +A + Sbjct 358 EEVKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTI----SDVGSRANALV 413 Query 412 EL-EYQGKIHKEISEGDGGYDAFMNALTKIT 441 EL + +G E ++G+G DA AL T Sbjct 414 ELSDPEGNRVAETAQGNGPVDALFGALASAT 444 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7] Sequence ID: A9MZK0.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Heidelberg str. SL476] Sequence ID: B4TJ72.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633] Sequence ID: B4TWW1.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853] Sequence ID: B5FI58.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Enteritidis str. P125109] Sequence ID: B5R2K9.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91] Sequence ID: B5RGE4.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase; Flags: Precursor [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Sequence ID: P15875.4 Length: 523 Range 1: 7 to 505 Score:150 bits(378), Expect:3e-38, Method:Compositional matrix adjust., Identities:138/515(27%), Positives:230/515(44%), Gaps:24/515(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +++ A + ED R D + +VE I +PDT+G P E F Sbjct 125 MVKRARNYTDDVEFSCEDAG---RTPVDDLARVVEAAINAGARTINIPDTVGYTMPFE-F 180 Query 190 QGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 G+ S L ++ P+I H H+D ++V NSL A+ AG + + ++NG+GERAGN Sbjct 181 AGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCA 240 Query 246 LEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 LE ++ I D N TNIN I S+ V I AN+ IVG F ++G+H Sbjct 241 LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIH 300 Query 303 ADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 DG K + PE G + L +G+A++ ++++G ++ + + + Sbjct 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAF 360 Query 362 IELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHK 421 ++L D+ V DL + + + + ++ SG A ++L +I Sbjct 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKA 420 Query 422 EISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLE 481 E + G+G DA A+ +IT G + +L+ Y++ GK DAL + I N Sbjct 421 EAANGNGPVDAIYQAINRIT---GYDV-ELVKYDLNAKGQGK-DALGQVDIVVN-----H 470 Query 482 EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 471 HGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Erwinia tasmaniensis Et1/99] Sequence ID: B2VDA7.1 Length: 522 Range 1: 7 to 505 Score:150 bits(378), Expect:3e-38, Method:Compositional matrix adjust., Identities:142/524(27%), Positives:236/524(45%), Gaps:42/524(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + ++ + A ++ S H+ +L T E Sbjct 62 ARQIKNSRVCGLARCVEKDIDAAYEALRVADAYRIHTFLATSPMHIATKLRSTLPE---- 117 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 VIE A+K + Y +D +G R D + +VE I +PDT+G Sbjct 118 ---VIERAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTINIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P E +L + P+I H H+D ++V N+L A+ AG + + ++NGLGE Sbjct 175 TLPYEYANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEGAMNGLGE 234 Query 240 RAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE + I + N T IN I + V I A++ I+G + F Sbjct 235 RAGNCALEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAIIGSNAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQ 355 ++G+H DG K + PE G K+ L +G+A++ ++++G +E + Sbjct 295 HSSGIHQDGVLKNRENYEILTPESIGLKQVQLNLTSRSGRAAVKHRMEEMGYGETEYNMD 354 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGE-KVLTIKSCNIHSGIGIRPHAQIELE 414 ++ + L D+ V DL +A ++ ++ E + + + N+ SG + A ++L Sbjct 355 RLYDAFKALADKKGQVFDYDLE-ALAFINQQSEEPEYFRLDTFNVQSGSSVIATATVQLR 413 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRI 472 + E + G+G DA A+ NRL +L+ Y++ GK DAL V+ + Sbjct 414 CGDEQKTEAATGNGPVDAVYQAI----NRLTEFDAELVSYQLTAKGHGK-DALGQVDIVV 468 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 +N + F +G+ D ++ A LN I + Q+ Sbjct 469 QYN-------GRKFHGVGLATDIVESSAKAMVNALNTIWRARQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Newport str. SL254] Sequence ID: B4SU36.1 Length: 523 Range 1: 7 to 505 Score:150 bits(378), Expect:3e-38, Method:Compositional matrix adjust., Identities:138/515(27%), Positives:230/515(44%), Gaps:24/515(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +++ A + ED R D + +VE I +PDT+G P E F Sbjct 125 MVKRARNYTDDVEFSCEDAG---RTPVDDLARVVEAAINAGARTINIPDTVGYTMPFE-F 180 Query 190 QGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 G+ S L ++ P+I H H+D ++V NSL A+ AG + + ++NG+GERAGN Sbjct 181 AGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCA 240 Query 246 LEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 LE ++ I D N TNIN I S+ V I AN+ IVG F ++G+H Sbjct 241 LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIH 300 Query 303 ADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 DG K + PE G + L +G+A++ ++++G ++ + + + Sbjct 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNIDHLYDAF 360 Query 362 IELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHK 421 ++L D+ V DL + + + + ++ SG A ++L +I Sbjct 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKA 420 Query 422 EISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLE 481 E + G+G DA A+ +IT G + +L+ Y++ GK DAL + I N Sbjct 421 EAANGNGPVDAIYQAINRIT---GYDV-ELVKYDLNAKGQGK-DALGQVDIVVN-----H 470 Query 482 EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 471 HGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. arizonae serovar 62:z4,z23:-] Sequence ID: A9MQD8.1 Length: 523 Range 1: 7 to 505 Score:149 bits(377), Expect:3e-38, Method:Compositional matrix adjust., Identities:137/517(26%), Positives:231/517(44%), Gaps:28/517(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ---KIM 66 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ +I+ Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARII 65 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + + L +E D + +K + A ++ S H+ +L T E Sbjct 66 KNSRVCALARCVE----KDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + + +VE I +PDT+G P Sbjct 122 AVYMVKRARNYTDDVEFSCEDAG---RTPVNDLARVVEAAINAGARTINIPDTVGYTMPF 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + + L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAGN Sbjct 179 EFARIISGLYERVPNIDNAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGN 238 Query 244 TPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE ++ I D N TNIN I S+ V I N+ IVG F ++G Sbjct 239 CALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPTNKAIVGSGAFAHSSG 298 Query 301 VHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + PE G + L +G+A++ ++++G S+ L ++ + Sbjct 299 IHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDRLYD 358 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 ++L D+ V DL + + + + ++ SG A ++L + Sbjct 359 AFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEET 418 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLD 479 E + G+G DA A+ +IT G + +L+ Y++ GK DAL + I N Sbjct 419 KAEAANGNGPVDAIYQAINRIT---GYDV-ELVKYDLNAKGQGK-DALGQVDIVVN---- 469 Query 480 LEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 470 -HHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=Homocitrate synthase AksA; AltName: Full=(R)-homo(2)citrate synthase; AltName: Full=(R)-homo(3)citrate synthase [Methanosarcina mazei Go1] Sequence ID: P58967.1 Length: 405 Range 1: 23 to 389 Score:147 bits(371), Expect:3e-38, Method:Compositional matrix adjust., Identities:116/383(30%), Positives:190/383(49%), Gaps:23/383(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 +EI DVTLRDGEQT GV FS +KL +A L + ++ +E VS E E V++I Sbjct 23 IEICDVTLRDGEQTPGVVFSKEQKLAVAS-ELDSMGIEVIEAGFPVVSADEKEIVKEI-- 79 Query 68 WAATEQLTERIEILG-FVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + RI L V G+ VD + ++++ S HL+ + ++ ++ Sbjct 80 --ANQGFNSRICCLSRAVKGD--VDAALECDVDIVSIFIAMSDMHLKYKYHRSLEDMLGC 135 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH-IERIFLPDTLGVLSP 185 IEYA GLK+ ED S R + +K + + E+ ++ + L DT+G+L+P Sbjct 136 AKEAIEYATDHGLKVRFAAEDAS---RTPVERLKQAFKEVENEYKVQYVSLADTVGILNP 192 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 T V S I K + H H+D ++ AN+L A AG K LH ++N +GERAGN Sbjct 193 TTTNYLV-SEIFKSVNTAICIHCHDDLGMATANTLAAAEAGAKQLHTTVNAIGERAGNAS 251 Query 246 LEALVTTIHDKSN----SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 LE ++ + + T +N + S +V +SG S N+ +VG++ FT +G+ Sbjct 252 LEEVLVALRVQYGIERYDTTKLNSL-----SEMVSEYSGITPSVNKAVVGKNAFTHESGI 306 Query 302 HADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 H + LPE G KR+ +GK GK ++ + +G L L ++E+V Sbjct 307 HVAAILEEPRTYELFLPEMVGGKRNLVVGKHTGKKALKGIINSIGFCLEREELCALIEKV 366 Query 362 -IELGDQNKLVTPEDLPFIIADV 383 + +++K ++ + L +I V Sbjct 367 KVCTEEKHKSISRDQLERLITQV 389 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter jejuni subsp. jejuni 81-176] Sequence ID: A1W1X2.1 Length: 511 Range 1: 3 to 505 Score:149 bits(376), Expect:4e-38, Method:Compositional matrix adjust., Identities:141/525(27%), Positives:231/525(44%), Gaps:35/525(6%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + ++ I D TLRDGEQ G S ++KL IA L+ L VD +E S+G+ + VQK Sbjct 3 DNKIIIFDTTLRDGEQALGSSLGINQKLQIA-LALENLGVDVIEAGFPVSSQGDFKAVQK 61 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + L D + + +K + ++ S H++ +L K Sbjct 62 IASKVKNSTICALSRALD-KDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKK------ 114 Query 125 TDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 D ++ A ++ ++ Y +D + R D + +VE+ K + I +PDT+ Sbjct 115 -DFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTV 173 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G P E + L K P+I H HND ++ NSL AI G + + +INGL Sbjct 174 GYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGVATGNSLSAILQGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 GERAGN LE +V I + + T+I I + S+LV + + I +++ IVG + Sbjct 234 GERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEV 352 F+ ++G+H DG K I P G + + +G+A I ++ LG + Sbjct 294 AFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTY 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 L V ER + L D+ V DL ++ E I+ ++ SG I P A + Sbjct 354 NLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENEFVIEKLSVISG-NI-PTACVC 411 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + + ++ E G+G +A N + +ITN P L Y + G DA + + Sbjct 412 MRIKEELKTEACTGNGPVEAVFNCIARITNLK----PALKAYSINAKSSG-VDAQGQVDV 466 Query 473 TWNKSLDLE-EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 DLE + + F G+ D A+ A N I + ++ Sbjct 467 ------DLEFKGRKFHGKGISTDVIEASAQAFVSAYNAIYRSLKV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella amazonensis SB2B] Sequence ID: A1S2E0.1 Length: 522 Range 1: 4 to 498 Score:149 bits(376), Expect:4e-38, Method:Compositional matrix adjust., Identities:140/523(27%), Positives:233/523(44%), Gaps:49/523(9%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S S EKL +A L++L VD +E+ S G+ E+VQ I Sbjct 4 RVIIFDTTLRDGEQALAASLSVKEKLQVA-LALERLGVDVMEVGFPVSSPGDFESVQTI- 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 A R+ L ++ ++ D+ A+ L++ + +H H+E +L + Sbjct 62 ---ARHIKNSRVCAL-----SRALEKDIDAAAQALSVAEQFRIHTFISTSNIHVESKLKR 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + + ++YA + + ED R D + +VE I +PD Sbjct 114 SFDQVLDMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAISAGARTINIPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E + +L + P+I H H+D LSVANS+ A++AG + + ++N Sbjct 171 TVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSIAAVQAGARQIECTVN 230 Query 236 GLGERAGNTPLE---ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE ++ T D TNIN I S LV I N+ IVG Sbjct 231 GIGERAGNCSLEEIAMILATRKDMLGLYTNINAREIHRTSSLVSQLCNMPIQPNKAIVGS 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSE 351 + FT ++G+H DG K + PE G R + + +G+ I ++++G + Sbjct 291 NAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYGAGD 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFII-----ADVSGRTGEKVLTIKSCNIHSGIGIR 406 + + ++L D+ V DL + A+ + L ++S + + Sbjct 351 YDMDTLYAAFLKLADKKGQVFDYDLEALAFMEAQAEDDDHYVMEQLVVQSDSTEG----K 406 Query 407 PHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNR-LGISIPKLIDYEVRIPPGGKTD 465 A + + ++ E + G+G DA NA+ + T+R + IS KL G + Sbjct 407 ATATVRMRVGDEVITEAATGNGPVDAAYNAIARATHRTINISSYKL------GAKGEGQN 460 Query 466 ALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 AL + IT +D+ F +G+ D A+ A ++N Sbjct 461 ALGQVDITARY-----DDRNFHGVGLATDVVEASAQALVHVMN 498 >RecName: Full=Methylthioalkylmalate synthase 1-1, chloroplastic; Short=EjMAM1-1; Flags: Precursor [Eutrema japonicum] Sequence ID: P0DO77.1 Length: 509 Range 1: 91 to 480 Score:149 bits(376), Expect:5e-38, Method:Compositional matrix adjust., Identities:112/394(28%), Positives:192/394(48%), Gaps:25/394(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + + D TLRDGEQ G + + +K+ IA L KL VD +E+ S+ E ET++ I + Sbjct 91 VRVYDTTLRDGEQAPGAALTPPQKIEIA-LQLAKLRVDVMEVGFPVSSEEEFETIKTIAK 149 Query 68 WAATE--QLTERIEILGFVDGNKTVD----W--IKDSGAKVLNLLTKGSLHHLEKQLGKT 119 E + T + ++ + + D W +K + + + T S H++ +L KT Sbjct 150 TVGNEVDEETGYVPVISALARSIQRDIEAAWESVKYAKRPRVGIFTPTSDIHMKYKLQKT 209 Query 120 PKEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 +E V+ + +A G K I ED R+ +++ ++ K + + D Sbjct 210 REEVIEMVASSVRFAKSLGCKDIQFGCEDAG---RSEKEFLCKILGEAIKAGATAVNVAD 266 Query 179 TLGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G+ PEE + V L P DI F H HND ++ AN++ + AG + + ++N Sbjct 267 TVGINMPEEYGELVRYLKANTPGIDDIVFSVHCHNDLGVATANTIAGVCAGARQVEVTVN 326 Query 236 GLGERAGNTPLEALVTTIHDKS-----NSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 G+GER+GN PLE +V + + T I+ I S++V+ ++G + ++PIV Sbjct 327 GIGERSGNAPLEEVVMALKCRGAYVMDGVYTRIDTRQIMATSKMVQEYTGLYVQPHKPIV 386 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLG 346 G + F +GVH DG K + PE G +S LGKL+G+ ++ + +K+LG Sbjct 387 GANCFVHESGVHQDGILKNRSTYEILSPEDVGVVKSQNSGIVLGKLSGRHAVKDRLKELG 446 Query 347 MVLSEVVLQKVLERVIELGDQNKLVTPEDLPFII 380 L + + R +L Q K +T DL ++ Sbjct 447 YELDDEKFNDIFSRFRDLTKQKKRITDADLKALV 480 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Typhi] Sequence ID: Q8Z9I0.3 Length: 523 Range 1: 7 to 505 Score:149 bits(376), Expect:5e-38, Method:Compositional matrix adjust., Identities:138/515(27%), Positives:230/515(44%), Gaps:24/515(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +++ A + ED R D + +VE I +PDT+G P E F Sbjct 125 MVKRARNYTDDVEFSCEDAG---RTPVDDLARVVEAAINAGARTINIPDTVGYTMPFE-F 180 Query 190 QGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 G+ S L ++ P+I H H+D ++V NSL A+ AG + + ++NG+GERAGN Sbjct 181 AGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCA 240 Query 246 LEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 LE ++ I D N TNIN I S+ V I AN+ IVG F ++G+H Sbjct 241 LEEVIMAIKVRKDIINVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIH 300 Query 303 ADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 DG K + PE G + L +G+A++ ++++G ++ + + + Sbjct 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMGHLYDAF 360 Query 362 IELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHK 421 ++L D+ V DL + + + + ++ SG A ++L +I Sbjct 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKA 420 Query 422 EISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLE 481 E + G+G DA A+ +IT G + +L+ Y++ GK DAL + I N Sbjct 421 EAANGNGPVDAIYQAINRIT---GYDV-ELVKYDLNAKGQGK-DALGQVDIVVN-----H 470 Query 482 EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 471 HGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Vibrio cholerae M66-2] Sequence ID: C3LR32.1 Length: 516 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Vibrio cholerae O1 biovar El Tor str. N16961] Sequence ID: Q9KP83.1 Length: 516 Range 1: 7 to 439 Score:149 bits(375), Expect:6e-38, Method:Compositional matrix adjust., Identities:121/443(27%), Positives:205/443(46%), Gaps:21/443(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA + L++L VD +E S G+ E+VQ I + Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-YALERLGVDIIEAGFPVSSPGDFESVQTIAKNI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + + +K + A ++ S H++ +L ++ + Sbjct 66 KNSRVCALSRAVA-KDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDD------- 117 Query 130 VIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 V+ A+K+ Y +D + R D + +VE I +PDT+G P Sbjct 118 VVAMAVKAVKHARQYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVP 177 Query 186 EETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E + +L + P+I H H+D +SVANS+ AI+AG + + +ING+GERAG Sbjct 178 SEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAIQAGARQVEGTINGIGERAG 237 Query 243 NTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE + I + T I I+ S+LV I +N+ IVG + F+ ++ Sbjct 238 NCALEEIAMIIKTRQELLGVTTGIKHDEISRTSKLVSQLCNMPIQSNKAIVGANAFSHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G K ++ L +G+A++ ++ +G +E L + Sbjct 298 GIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDSMGYNENEYNLDALY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 E ++L D+ V DL ++ + R + + ++ SG + I+L G+ Sbjct 358 EDFLKLADRKGQVFDYDLEALMHFSNLREEDDFYKLNYLSVQSG-SVMATTSIKLLCGGE 416 Query 419 IHKEISEGDGGYDAFMNALTKIT 441 E + G+G DA + +IT Sbjct 417 EKCEAAVGNGPVDALYQCIYRIT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salmonella enterica subsp. enterica serovar Agona str. SL483] Sequence ID: B5F7U9.1 Length: 523 Range 1: 7 to 505 Score:149 bits(375), Expect:6e-38, Method:Compositional matrix adjust., Identities:137/515(27%), Positives:230/515(44%), Gaps:24/515(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +++ A + ED R D + +VE I +PDT+G P E F Sbjct 125 MVKRARNYTDDVEFSCEDAG---RTPVDDLARVVEAAINAGARTINIPDTVGYTMPFE-F 180 Query 190 QGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 G+ S L ++ P+I H H+D ++V NSL A+ AG + + ++NG+GERAGN Sbjct 181 AGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCA 240 Query 246 LEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 LE ++ I D N TNIN I S+ V I AN+ IVG F ++G+H Sbjct 241 LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIH 300 Query 303 ADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 DG K + PE G + L +G+A++ ++++G ++ + + + Sbjct 301 QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAF 360 Query 362 IELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHK 421 ++L D+ V DL + + + + ++ SG A ++L +I Sbjct 361 LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKA 420 Query 422 EISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLE 481 E + G+G DA A+ ++T G + +L+ Y++ GK DAL + I N Sbjct 421 EAANGNGPVDAIYQAINRLT---GYDV-ELVKYDLNAKGQGK-DALGQVDIVVN-----H 470 Query 482 EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 471 HGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=Probable 2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase; AltName: Full=Late nodulin-56; Short=N-56 [Glycine max] Sequence ID: Q39891.1 Length: 565 Range 1: 33 to 559 Score:149 bits(377), Expect:6e-38, Method:Compositional matrix adjust., Identities:145/537(27%), Positives:241/537(44%), Gaps:39/537(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + ILD TLRDGEQ+ G + + EKL+IA+ L+ KL VD ++ S + V+ I + Sbjct 33 VRILDTTLRDGEQSPGATMTAKEKLDIARQLV-KLGVDIIQPGFPSASNSDFMAVKMIAQ 91 Query 68 WA--ATEQLTERIEILGF---VDGNKTVDWIKDSGAKVLNLLTK--GSLHHLEKQLGKTP 120 A + I GF V+ + + W AK L T S H+E +L K+ Sbjct 92 EVGNAVDDDGYVPVIAGFCRCVEKDISTAWEAVKYAKRPRLCTSIATSPIHMEHKLRKSK 151 Query 121 KEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 + ++++A G I ED + R+ +++ ++ + + + + DT Sbjct 152 DQVIQIARDMVKFARSLGCNDIQFGAEDAT---RSDREFLYEILGVVIEAGATTVNIADT 208 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G++ P E + + + P I H HND L+ AN+++ R G + L +ING Sbjct 209 VGIVMPLELGKLIVDIKDNTPGIANVIISTHCHNDLGLATANTIEGARTGARQLEVTING 268 Query 237 LGERAGNTPLEALVTTIHDKSNSKTN-----INEIAITEASRLVEVFSGKRISANRPIVG 291 +GERAGN LE +V + K + N IN I E S++VE +SG + ++P+VG Sbjct 269 IGERAGNASLEEVVMALASKGDHALNGLYTRINTRHILETSKMVEEYSGMHLQPHKPLVG 328 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLGM 347 + F +G+H DG K I PE G KR+ LGKL+G ++ + +++LG Sbjct 329 ANAFVHASGIHQDGMLKHKGTYETISPEEIGHKRTTRIGIVLGKLSGSQALRKRLEELGY 388 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSG-IGIR 406 L E + V + + ++ K+VT DL +++ E + + + G IG+ Sbjct 389 DLKEDEVDSVFWQFKAMAEKKKVVTDVDLKALVS-YKAFHAESIWKLGDLQVTCGTIGLS 447 Query 407 PHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVR-IPPGGKTD 465 + G H S G G D+ A+ I KL+DY + + G + Sbjct 448 TATVKLVNIDGSTHVACSIGIGAVDSTYKAINLIVKEP----TKLLDYSLNSVTEGIGVN 503 Query 466 ALVETRIT----WNKSLDLEEDQ---TFKTMGVHPDQTVAAVHATEKMLNQILQPWQ 515 I + ED TF + D V+ V A LN++L+ W+ Sbjct 504 VTARVVICRENNHTSTYAFTEDANYPTFSGIAAEMDVVVSTVKAYLVALNKLLR-WK 559 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Tolumonas auensis DSM 9187] Sequence ID: C4LAV7.1 Length: 521 Range 1: 4 to 505 Score:149 bits(375), Expect:7e-38, Method:Compositional matrix adjust., Identities:142/525(27%), Positives:234/525(44%), Gaps:38/525(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ E+VQ I Sbjct 4 RVIIFDTTLRDGEQALPASLTVREKLQIA-LALERLGVDVMEVGFPVSSPGDFESVQTI- 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 A + R+ L ++ + D+ A+ L + + +H H+E +L K Sbjct 62 ---ARQIKNSRVCAL-----SRALQKDIDAAAEALKVADQFRIHTFLATSTIHVESKLKK 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++ ++YA + + ED R D + +VE I +PD Sbjct 114 SFEDVLEMGINAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAINAGARTINIPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E + +L + P+I H H+D LSVANS+ A++ G + + +IN Sbjct 171 TVGYTIPSEFGGIIHNLFNRVPNIDKAVISVHCHDDLGLSVANSISAVQMGARQVECTIN 230 Query 236 GLGERAGNTPLE---ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGNT LE ++ T D TNI I S+LV + N+ IVG Sbjct 231 GIGERAGNTSLEEVAMILRTRQDLIGVHTNIKHQEIHRTSQLVSQLCNMPVQPNKAIVGA 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSE 351 + F+ ++G+H DG K I PE G + + L +G+ I + LG Sbjct 291 NAFSHSSGIHQDGVLKAKNTYEIITPESVGLNQNTLNLTSRSGRHVIKHRLALLGYPEGS 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L ++ ++L D+ V DL ++ + + + ++ SG I A + Sbjct 351 YDLDQIYTSFLQLADKKGQVFDYDLEALLFFSQIQEEPEHFKLNYLSVQSGGSIMATASV 410 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETR 471 ++ + E + G+G DA + +IT I+I K Y+++ GK DAL + Sbjct 411 RMKVGDEEVTEAATGNGPVDAVYQCINRITG-YEINISK---YDLKSKGIGK-DALGQVD 465 Query 472 ITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 I + + F MG+ D ++ A ++N I + Q+ Sbjct 466 IVAEF-----KGRKFHGMGLATDIVESSAQALVHVINNIYRALQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola str. Sg (Schizaphis graminum)] Sequence ID: O85063.1 Length: 518 Range 1: 1 to 506 Score:148 bits(374), Expect:1e-37, Method:Compositional matrix adjust., Identities:135/523(26%), Positives:237/523(45%), Gaps:27/523(5%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + +++ I D TLRDGEQ S S +KL IA L+ +D +E+ S G+ ++VQ Sbjct 1 MNSQVIIFDTTLRDGEQALQASLSVKQKLQIA-LSLENAGIDIIEVGFPISSPGDFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 I + ++ L D + + + S +++ S H+E +L K + Sbjct 60 TISKNIKNSRICSLARCLN-KDIDTAAEAMSSSNTFRIHIFLATSTLHMESKLKKNFDQI 118 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 ++ A++ + ED S R + D + +VE L K ++ I +PDT+G Sbjct 119 IDMAISSVKRALRYTDDVEFSCEDAS---RTTMDNLCRIVEQLIKAGVKTINIPDTVGYT 175 Query 184 SPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P E + +L ++ P+I H HND ++V NS+ AI+AG + + +ING+GER Sbjct 176 VPNELSTIIHNLFKRVPNIDQSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGER 235 Query 241 AGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE ++ I D TNI I S+++ I N+ IVG + F Sbjct 236 AGNTALEEVIMAIKVREDILGVSTNIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAH 295 Query 298 TAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQK 356 ++G+H DG K + P G K L +G+A++ + Q+G + + + Sbjct 296 SSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKYYMTQMGYKECDYNIDE 355 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQ 416 + ++L D+ V DL + + + ++ ++ S A ++L Sbjct 356 LYTSFLKLADKKGQVFDYDLEALAFINMQQEESEYFSLSFFSVQSISNGLSTASVKLLCG 415 Query 417 GKIHKE-ISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRIT 473 K+ E + +G DA AL +ITN I++ K Y++ + G DAL V+ + Sbjct 416 KKVSIESATTSNGPIDAIYQALNRITN-FPITLQK---YQL-VAKGKGRDALGQVDILVE 470 Query 474 WNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + K + F +G+ D ++ A +LN I + Q+ Sbjct 471 YKK-------RKFHGVGLATDIIESSAQAMVNVLNNIWKANQV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter jejuni RM1221] Sequence ID: Q5HS76.1 Length: 511 Range 1: 3 to 505 Score:148 bits(373), Expect:1e-37, Method:Compositional matrix adjust., Identities:141/525(27%), Positives:230/525(43%), Gaps:35/525(6%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + ++ I D TLRDGEQ G S ++KL IA L+ L VD +E S+G+ + VQK Sbjct 3 DNKIIIFDTTLRDGEQALGSSLGINQKLQIA-LALENLGVDVIEAGFPVSSQGDFKAVQK 61 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + L D + + +K + ++ S H++ +L K Sbjct 62 IASKVKNSTICALSRALD-KDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKK------ 114 Query 125 TDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 D ++ A ++ ++ Y +D + R D + +VE+ K + I +PDT+ Sbjct 115 -DFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTV 173 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G P E + L K P+I H HND ++ NSL AI G + + +INGL Sbjct 174 GYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 GERAGN LE +V I + + T+I I + S+LV + + I +++ IVG + Sbjct 234 GERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEV 352 F+ ++G+H DG K I P G + +G+A I ++ LG + Sbjct 294 AFSHSSGIHQDGVLKNRQTYEIISPSAIGIHDNRMLMTARSGRAMIKTCLENLGYDENTY 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 L V ER + L D+ V DL ++ E I+ ++ SG I P A + Sbjct 354 NLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENEFVIEKLSVISG-NI-PTACVC 411 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + + ++ E G+G +A N + +ITN P L Y + G DA + + Sbjct 412 MRIKEELKTEACTGNGPVEAVFNCIARITNLK----PVLKAYSINAKSSG-VDAQGQVDV 466 Query 473 TWNKSLDLE-EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 DLE + + F G+ D A+ A N I + ++ Sbjct 467 ------DLEFKGRKFHGKGLSTDVIEASAQAFASAYNAIYRSLKV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aeromonas hydrophila subsp. hydrophila ATCC 7966] Sequence ID: A0KGM9.1 Length: 524 Range 1: 4 to 505 Score:148 bits(374), Expect:1e-37, Method:Compositional matrix adjust., Identities:139/518(27%), Positives:234/518(45%), Gaps:24/518(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S + EKL IA+ L++L VD +E+ S G+ ++VQ I Sbjct 4 RVIIFDTTLRDGEQALAASLTVKEKLQIAQ-ALERLGVDVMEVGFPVSSPGDFQSVQTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 ++ L D + + ++ + A ++ S H+E +L K+ ++ Sbjct 63 RHIKQSRVCALARALP-KDIDAAGEALRVAEAFRIHTFISTSSIHVESKLKKSFEDVLEM 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 I++A + + ED R D + +VE K I +PDT+G P Sbjct 122 GVSAIKHARRYTDDVEFSCEDAG---RTPIDNLCRMVEAAIKAGARTINIPDTVGYTVPT 178 Query 187 ETFQGV-DSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ +L + P+I H H+D LSVANS+ A++ G + + +ING+GERAG Sbjct 179 E-FSGIIQTLFNRVPNIDQAIISVHCHDDLGLSVANSIGAVQMGARQIECTINGIGERAG 237 Query 243 NTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE + + +++ TNI I S LV + N+ IVG + F+ ++ Sbjct 238 NCSLEEVAMILKTRADLLGVHTNIRHSEIHRTSALVSQLCNMPVQPNKAIVGANAFSHSS 297 Query 300 GVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K I PE G + + + +G+ I ++ +G S L + Sbjct 298 GIHQDGVLKAKNTYEIITPESIGLTQNNLNMTSRSGRHVIKHRMESMGYAESSYDLDDLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + + L D+ V DL + + ++ + SG + A ++L+ + Sbjct 358 GKFLTLADKKGQVFDYDLEALAFFSQIHEEPEHFKLEYLGVQSGSSVMATASVKLKVGQE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 I E + G+G DA + +IT ISI K YE++ GK +AL + I Sbjct 418 IVSEAATGNGPVDAVYQCINRITG-YEISIDK---YELKGKGEGK-NALGQVDIVAQY-- 470 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + + F MG+ D ++ A ++N I + Q+ Sbjct 471 ---KGRKFHGMGLATDIIESSAQALIHVINSIWRADQV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Paraglaciecola sp. T6c] Sequence ID: Q15QR4.1 Length: 519 Range 1: 1 to 506 Score:148 bits(374), Expect:1e-37, Method:Compositional matrix adjust., Identities:137/528(26%), Positives:232/528(43%), Gaps:37/528(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + +++I D TLRDGEQ S S EKL IA L++L VD +E S G+ +V+ Sbjct 1 MSNQVKIFDTTLRDGEQALAASLSMKEKLQIA-LALERLGVDIIEAGFPVSSPGDFRSVR 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I Q + + G ++ ++ D+ + L++ +H H+ + Sbjct 60 SIA------QEVKNATVCGL---SRALEKDIDACGEALSVADNFRIHTFIATSDIHVANK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L K+ E I++A + I ED R DY+ +VE + Sbjct 111 LRKSQDEVVEMAVNAIKHAGRYTDDIEFSCEDAG---RTPIDYLCRMVESAINAGATTVN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G +P E + +L + P+I H HND L+VANSL A+ G + + Sbjct 168 IPDTVGYTTPTEFGGIIQNLFNRVPNIDKATISVHCHNDLGLAVANSLVAVEYGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 +ING+GERAGN LE + + + TNI I+ S+LV + +N+ I Sbjct 228 TINGIGERAGNCSLEEIAMILQTRQAMLGLNTNIRSHEISRTSKLVSQLCNMPVQSNKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMV 348 VG + F+ ++G+H DG K + PE G K + L +G+ I +++LG Sbjct 288 VGANAFSHSSGIHQDGVLKAQNTYEIMTPESVGINKNNLNLTSRSGRHVIKHRLEELGYK 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPH 408 + L + ++L D+ V DL ++ + ++ + SG I P Sbjct 348 AEDYDLDTLYASFVKLADKKGQVFDYDLEALLFFDKQKPADEHYKLLYLQASSGKEIIPS 407 Query 409 AQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALV 468 A ++L+ + E G+G DA A+ K+ LG +++D+++ G DAL Sbjct 408 ATVKLQVGEEEIIESCTGNGPVDAAYKAIIKV---LGHEQLEIVDFKLD-SKGEGADALA 463 Query 469 ETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + + + + F +G+ D + V A +LN QI Sbjct 464 QVSVIVEYN-----GRRFNGIGLATDIVESGVKALIHVLNNTHLADQI 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli O127:H6 str. E2348/69] Sequence ID: B7UIC4.1 Length: 523 Range 1: 7 to 505 Score:148 bits(373), Expect:1e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:231/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E++ G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEVANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella denitrificans OS217] Sequence ID: Q12SE7.1 Length: 522 Range 1: 4 to 506 Score:148 bits(373), Expect:1e-37, Method:Compositional matrix adjust., Identities:135/522(26%), Positives:232/522(44%), Gaps:31/522(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S S EKL IA L++L VD +E+ S G+ +VQ I Sbjct 4 RVIIFDTTLRDGEQALAASLSVKEKLQIA-LALERLGVDVMEVGFPVSSPGDFNSVQTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + ++ L ++ ++ ++H +E +L ++ + Sbjct 63 KTIKNSRVCALARALPADIDAAAQALAVAEQFRIHTFISTSTIH-VESKLKRSFDDVLAM 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++YA + + ED R D + +VE I +PDT+G P Sbjct 122 AVNAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEAAITAGARTINIPDTVGYTIPS 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E +++L + P+I H H+D LSVANS+ AI G + + ++NG+GERAGN Sbjct 179 EFSTIIETLFNRVPNIDQAIISVHCHDDLGLSVANSIGAIEKGARQVECTVNGIGERAGN 238 Query 244 TPLE---ALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE ++ T DK +T I I S LV + AN+ IVG + F+ ++G Sbjct 239 CSLEEIAMILATRKDKLGLETGIVAKEIHRTSNLVSQLCNMPVQANKAIVGSNAFSHSSG 298 Query 301 VHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + PE G R + + +G+ I ++++G + + + E Sbjct 299 IHQDGMLKAKNTYEIMTPESIGLHRNNLNMTSRSGRHVIKHRMEEMGYHTDDFDIDSLYE 358 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHS----GIGIRPHAQIELEY 415 + ++L D+ V DL I+ + + ++ ++HS G+ A + ++ Sbjct 359 QFLKLADKKGQVFDYDLEAIVFMATQVAEDDHYRLQHLSVHSDSSEGVAT---ATVRIKV 415 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNR-LGISIPKLIDYEVRIPPGGKTDALVETRITW 474 +G+ E + G+G DA A+ + + R + IS KL G DAL + IT Sbjct 416 EGEDLTEAAIGNGPVDAAYKAIARASGREVEISSYKL------SAKGQGQDALGQVDITA 469 Query 475 NKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + +TF +G+ D A+ A ++N I + ++ Sbjct 470 KY-----QGRTFHGVGLATDVVEASAQALVHVMNLICRADKV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819] Sequence ID: Q9PLV9.1 Length: 511 Range 1: 3 to 505 Score:147 bits(372), Expect:2e-37, Method:Compositional matrix adjust., Identities:140/525(27%), Positives:231/525(44%), Gaps:35/525(6%) Query 5 ETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQK 64 + ++ I D TLRDGEQ G S ++KL IA L+ L VD +E S+G+ + VQK Sbjct 3 DNKIIIFDTTLRDGEQALGSSLGINQKLQIA-LALENLGVDVIEAGFPVSSQGDFKAVQK 61 Query 65 IMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 I + L D + + +K + ++ S H++ +L K Sbjct 62 IASKVKNSTICALSRALD-KDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKK------ 114 Query 125 TDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 D ++ A ++ ++ Y +D + R D + +VE+ K + I +PDT+ Sbjct 115 -DFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTV 173 Query 181 GVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 G P E + L K P+I H HND ++ NSL AI G + + +INGL Sbjct 174 GYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGL 233 Query 238 GERAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 GERAGN LE +V I + + T+I I + S+LV + + I +++ IVG + Sbjct 234 GERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSN 293 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEV 352 F+ ++G+H DG K I P G + + +G+A I ++ LG + Sbjct 294 AFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTY 353 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 L V ER + L D+ V DL ++ E ++ ++ SG I P A + Sbjct 354 NLDDVYERFLRLADKKGQVYDYDLEALMFLSYESEEENEFVLEKLSVISG-NI-PTACVC 411 Query 413 LEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 + + ++ E G+G +A N + +ITN P L Y + G DA + + Sbjct 412 MRIKEELKTEACTGNGPVEAVFNCIARITNLK----PALKAYSINAKSSG-VDAQGQVDV 466 Query 473 TWNKSLDLE-EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 DLE + + F G+ D A+ A N I + ++ Sbjct 467 ------DLEFKGRKFHGKGLSTDVIEASAQAFVSAYNAIYRSLKV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aliivibrio salmonicida LFI1238] Sequence ID: B6ELK0.1 Length: 515 Range 1: 7 to 439 Score:147 bits(372), Expect:2e-37, Method:Compositional matrix adjust., Identities:120/450(27%), Positives:207/450(46%), Gaps:35/450(7%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME-- 67 I D TLRDGEQ S + EKL IA F L++L VD +E S G+ E+V+ I + Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-FALERLGVDVIEAGFPISSPGDFESVRTIAKHI 65 Query 68 -----WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKE 122 A + +T+ I++ D +K + A ++ S H++ +L ++ + Sbjct 66 KNSRICALSRAVTKDIDV--------AADALKVAEAFRIHTFISTSTVHVQDKLRRSYDD 117 Query 123 FFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 V+E +K+ + Y +D + R D + +VE I +PD Sbjct 118 -------VVEMGVKAVQRARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGANTINIPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E + +L + P+I H H+D +SVANS+ A++AG + + +IN Sbjct 171 TVGYTIPGEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTIN 230 Query 236 GLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + + +S T++ I S+LV I +N+ IVG Sbjct 231 GIGERAGNCSLEEIAMILQTRSEYLGVHTSLKNDEIHRTSKLVSQLCNMPIQSNKAIVGA 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSE 351 + F+ ++G+H DG K + PE G K ++ L +G+A++ ++ +G E Sbjct 291 NAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNKALNLTSRSGRAAVKSHMDSMGYKAEE 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQI 411 L + ++L D+ V DL ++ + R + + ++ SG + I Sbjct 351 YNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSG-SVMATTSI 409 Query 412 ELEYQGKIHKEISEGDGGYDAFMNALTKIT 441 +L + E + G+G DA + K+T Sbjct 410 KLLCGDEEKCEAAVGNGPVDALYQCIYKLT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Campylobacter jejuni subsp. doylei 269.97] Sequence ID: A7H667.1 Length: 511 Range 1: 5 to 505 Score:147 bits(371), Expect:2e-37, Method:Compositional matrix adjust., Identities:140/523(27%), Positives:231/523(44%), Gaps:35/523(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ G S ++KL IA L+ L VD +E S+G+ + VQKI Sbjct 5 KIIIFDTTLRDGEQALGSSLGINQKLQIA-LALENLGVDVIEAGFPVSSQGDFKAVQKIA 63 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + L D + + +K + ++ S H++ +L K D Sbjct 64 SKVKNSTICALSRALD-KDIDMAYEALKVAKHFRIHTFIATSTLHIQDKLKK-------D 115 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 ++ A ++ ++ Y +D + R D + +VE+ K + I +PDT+G Sbjct 116 FDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGY 175 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P E + L K P+I H HND ++ NSL AI G + + +INGLGE Sbjct 176 TLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGE 235 Query 240 RAGNTPLEALVTTIHDKSNS----KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 RAGN LE +V I + + T+I I++ S+LV + + I +++ IVG + F Sbjct 236 RAGNCALEEVVMAIKTRKDYLQGFYTDIKCENISKTSKLVSAITNESIPSHKAIVGSNAF 295 Query 296 TQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVL 354 + ++G+H DG K I P G + + +G+A I ++ LG + L Sbjct 296 SHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNL 355 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 V ER + L D+ V DL ++ E ++ ++ SG I P A + + Sbjct 356 DDVYERFLRLADKKGQVYDYDLEALMFLSYESEEENEFVLEKLSVISG-NI-PTACVCMR 413 Query 415 YQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITW 474 + ++ E G+G +A N + +ITN P L Y + G DA + + Sbjct 414 IKEELKTEACTGNGPVEAVFNCIARITNLK----PVLKAYSINAKSSG-VDAQGQVDV-- 466 Query 475 NKSLDLE-EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 DLE + + F G+ D A+ A N I + ++ Sbjct 467 ----DLEFKGRKFHGKGLSTDVIEASAQAFVSAYNAIYRSLKV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas oryzae pv. oryzae PXO99A] Sequence ID: B2SNG9.2 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas oryzae pv. oryzae MAFF 311018] Sequence ID: Q2P761.1 Length: 520 Range 1: 12 to 444 Score:147 bits(371), Expect:2e-37, Method:Compositional matrix adjust., Identities:121/442(27%), Positives:206/442(46%), Gaps:17/442(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ+ G S + +KL +A+ L +L VD +E S + E V + Sbjct 12 IRIFDTTLRDGEQSPGCSMTPQQKLVMAR-ALDELGVDIIETGFPASSHSDREAVAMMGR 70 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 L L D + ++ + L++ S H E +L + ++ V Sbjct 71 ELRRPTLAVLSRCLQ-ADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESV 129 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 + A + ED + R D++ + I LPDT+G +PEE Sbjct 130 HRHVTLARGYIDDVEFSAEDAT---RTEEDFLAEVTRVAVAAGATTINLPDTVGFTTPEE 186 Query 188 ---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 F + + ++ + F H HND L+VANSL AI G + + +ING+GERAGN Sbjct 187 IRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNC 246 Query 245 PLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 LE + + + N + IN I S+L++ G + N+ +VG + F +G+ Sbjct 247 ALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGI 306 Query 302 HADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLER 360 H G + + PE G + S LG+ +G+A++ ++ LG +L E ++ + E+ Sbjct 307 HQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEEEVKLMFEQ 366 Query 361 VIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQGKI 419 L ++ +LVT DL ++ D + + G ++ ++ S +G R +A +EL + +G Sbjct 367 FKALCEKQRLVTDADLQALMQDATVQEGYRLASMTI----SDVGSRANALVELSDPEGNR 422 Query 420 HKEISEGDGGYDAFMNALTKIT 441 E ++G+G DA AL T Sbjct 423 VAETAQGNGPVDALFGALASAT 444 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shigella sonnei Ss046] Sequence ID: Q3Z5T6.1 Length: 523 Range 1: 7 to 505 Score:147 bits(371), Expect:3e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:230/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSSAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli ED1a] Sequence ID: B7MNT2.1 Length: 523 Range 1: 7 to 505 Score:147 bits(370), Expect:3e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:230/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ALQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli SMS-3-5] Sequence ID: B1LG11.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia fergusonii ATCC 35469] Sequence ID: B7LWE2.1 Length: 523 Range 1: 7 to 505 Score:147 bits(370), Expect:3e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:230/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSAKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas oryzae pv. oryzae KACC 10331] Sequence ID: Q5H4C6.1 Length: 520 Range 1: 12 to 444 Score:147 bits(370), Expect:3e-37, Method:Compositional matrix adjust., Identities:122/450(27%), Positives:209/450(46%), Gaps:33/450(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ+ G S + +KL +A+ L L VD +E S + E V + Sbjct 12 IRIFDTTLRDGEQSPGCSMTPQQKLVMAR-ALDALGVDIIETGFPASSHSDREAVAMM-- 68 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKT 119 E + +L ++ + ++ A+ L + LH H E +L + Sbjct 69 --GRELRRPTLAVL-----SRCLQADIETSARALETVANPRLHVFLSTSPLHREHKLRMS 121 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 ++ V + A + ED + R D++ + I LPDT Sbjct 122 REQVLESVHRHVTLARGYIDDVEFSAEDAT---RTEEDFLAEVTRVAVAAGATTINLPDT 178 Query 180 LGVLSPEE---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G +PEE F + + ++ + F H HND L+VANSL AI G + + +ING Sbjct 179 VGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTING 238 Query 237 LGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 +GERAGN LE + + + N + IN I S+L++ G + N+ +VG + Sbjct 239 IGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGN 298 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEV 352 F +G+H G + + PE G + S LG+ +G+A++ ++ LG +L E Sbjct 299 AFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEE 358 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 ++ + E+ L ++ +LVT DL ++ D + + G ++ ++ S +G R +A +E Sbjct 359 EVKLMFEQFKALCEKQRLVTDADLQALMQDATVQEGYRLASMTI----SDVGSRANALVE 414 Query 413 L-EYQGKIHKEISEGDGGYDAFMNALTKIT 441 L + +G E ++G+G DA AL T Sbjct 415 LSDPEGNRVAETAQGNGPVDALFGALASAT 444 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli APEC O1] Sequence ID: A1A7C2.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli O139:H28 str. E24377A] Sequence ID: A7ZHG6.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli HS] Sequence ID: A7ZW25.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli ATCC 8739] Sequence ID: B1IRA4.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shigella boydii CDC 3083-94] Sequence ID: B2U281.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli SE11] Sequence ID: B6HZ24.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli 55989] Sequence ID: B7LFU5.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli IAI1] Sequence ID: B7M119.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli S88] Sequence ID: B7MAJ9.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli IAI39] Sequence ID: B7NHI2.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli 536] Sequence ID: Q0TLR5.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli UTI89] Sequence ID: Q1RGC3.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shigella boydii Sb227] Sequence ID: Q326G1.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli CFT073] Sequence ID: Q8FL75.3 Length: 523 Range 1: 7 to 505 Score:147 bits(370), Expect:3e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:230/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Vibrio atlanticus LGP32] Sequence ID: B7VIF2.1 Length: 515 Range 1: 7 to 439 Score:146 bits(369), Expect:4e-37, Method:Compositional matrix adjust., Identities:123/451(27%), Positives:208/451(46%), Gaps:37/451(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA + L++L VD +E S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALAASLTVKEKLQIA-YALERLGVDVIEAGFPISSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A RI L ++ V D+ A+ L + + +H H++ +L ++ Sbjct 62 AKHIKDSRICAL-----SRAVAKDIDAAAEALKVADQFRIHTFISTSTVHVQDKLRRSYD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + V+E A+K+ Y +D + R D + +VE + I +P Sbjct 117 D-------VVEMAVKAVKHARNYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGAKTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G P E + +L + P+I H H+D +SVANS+ A++AG + + +I Sbjct 170 DTVGYTVPNEFGGIIKTLFDRVPNIDQAIISVHCHDDLGMSVANSIAAVQAGARQIEGTI 229 Query 235 NGLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGN LE + I + T ++ I S+LV I N+ IVG Sbjct 230 NGIGERAGNCSLEEIAMIIKTRQELLGVHTGLDHKEIHRTSKLVSQLCHMPIQDNKAIVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLS 350 + F+ ++G+H DG K + PE G K ++ L +G+A++ ++ +G + Sbjct 290 ANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNKALNLTSRSGRAAVKSHMDAMGYKDN 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 E L + E ++L D+ V DL ++ + R + + ++ SG + Sbjct 350 EYNLDSLYEDFLKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSG-SVMSTTS 408 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKIT 441 I+L+ + E + G+G DA + ++T Sbjct 409 IKLQCGDEEKCEAAVGNGPVDALYQCIYRLT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4115] Sequence ID: B5YZB0.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli UMN026] Sequence ID: B7N7U9.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli O157:H7] Sequence ID: Q8X9Z8.3 Length: 523 Range 1: 7 to 505 Score:147 bits(370), Expect:4e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:230/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRATEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shigella flexneri] Sequence ID: Q83SP0.3 Length: 523 Range 1: 7 to 505 Score:146 bits(369), Expect:4e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:230/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVTNYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Uroleucon erigeronensis)] Sequence ID: Q9EVH6.1 Length: 503 Range 1: 1 to 493 Score:146 bits(368), Expect:5e-37, Method:Compositional matrix adjust., Identities:139/518(27%), Positives:237/518(45%), Gaps:43/518(8%) Query 17 DGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQLT- 75 DGEQ S S EKL IA L+K VD +E+ S G+ ++VQ I + Q+ Sbjct 1 DGEQALQASLSVEEKLXIA-LCLEKTGVDIMEVGFPISSPGDFKSVQTISKKIKNSQICS 59 Query 76 ------ERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 + I+I G + D+ + +++ S H++ +L K E F Sbjct 60 LARCIEKDIDIAG--EAMSVCDFFR------IHIFLATSRLHMKSKLRKNFDEIIDMAIF 111 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 ++ A++ + ED S R + D + +VE L ++ I +PDT+G P E Sbjct 112 SVKRALRYTDDVQFSCEDAS---RTTIDNLCRIVEKLINSGVKTINIPDTVGYSIPNELS 168 Query 190 QGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + +L Q+ P+I H H+D ++V NS+ AI+AG + + +ING+GERAGNT L Sbjct 169 FIIKNLFQRVPNIDKAVISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTAL 228 Query 247 EALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 E ++ I + + TNIN I S+++ I +N+ IVG + F+ ++G+H Sbjct 229 EEVIMAIKVREKNLGVYTNINHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQ 288 Query 304 DGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVI 362 DG K I P G K L +G+A++ + ++G S+ + ++ + Sbjct 289 DGVLKNRENYEIIDPVSIGLKNVQLNLTSRSGRAAVKYYMNEMGYKDSDYNIDELYSDFL 348 Query 363 ELGDQNKLVTPEDLPFIIADVSGRTGE-KVLTIKSCNIHSGIGIRPHAQIELEYQGKIHK 421 +L D+ V DL +A +S + E + +K ++ S A ++L K++ Sbjct 349 KLADKKGQVFDYDLES-LAFISKQQDELEYFCLKFFSVQSISNGLSTASVKLLCGKKVYT 407 Query 422 EIS-EGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRITWNKSL 478 E S +G DA AL +IT+ P + I G DAL V+ + + K Sbjct 408 ESSTTSNGPVDAIYQALNRITH-----FPITLQKFQLIAKGKGKDALGQVDILVEYKK-- 460 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + Q+ Sbjct 461 -----RKFHGVGLATDIIESSAKAMINVLNNIWKAKQV 493 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shigella flexneri 5 str. 8401] Sequence ID: Q0T8C4.1 Length: 523 Range 1: 7 to 505 Score:146 bits(369), Expect:5e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:230/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIGKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella piezotolerans WP3] Sequence ID: B8CM39.1 Length: 523 Range 1: 4 to 498 Score:146 bits(369), Expect:5e-37, Method:Compositional matrix adjust., Identities:134/518(26%), Positives:230/518(44%), Gaps:39/518(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ E+VQ I Sbjct 4 RVIIFDTTLRDGEQALAASLTVKEKLQIA-LALERLGVDVMEVGFPVSSPGDFESVQTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 ++ ++ ++ D+ A+ L++ + +H H+E +L + Sbjct 63 RTVKNSRVCAL---------SRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKR 113 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + + ++YA + + ED R D + +VE K I +PD Sbjct 114 SFDQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEEAIKAGARTINIPD 170 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 T+G P E + +L + P+I H H+D LSVANS+ A++ G + + ++N Sbjct 171 TVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTVN 230 Query 236 GLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 G+GERAGN LE + + + +T IN I S LV + AN+ IVG Sbjct 231 GIGERAGNCSLEEIAMILSTRKGELGLETGINAKEIHRTSSLVSQLCNMPVQANKAIVGA 290 Query 293 DVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSE 351 + FT ++G+H DG K + PE G R + + +G+ I + +LG + Sbjct 291 NAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMSELGYGDQD 350 Query 352 VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHS-GIGIRPHAQ 410 + + E + L D+ V DL + + + ++ +HS A Sbjct 351 YDMDVLYEDFLVLADKKGQVFDYDLEALAFMEAQAEDDDHFKLQQLVVHSDSTEGSATAT 410 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVET 470 +++E G+ E + G+G DA A+ + + G I + Y++ G+ +AL + Sbjct 411 VKVEVNGETVTEAAIGNGPVDAAYKAVARAS---GCEI-DITSYQLGAKGEGQ-NALGQV 465 Query 471 RITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 IT + +Q F +G+ D A+V A ++N Sbjct 466 DITASY-----RNQNFHGVGLATDVVEASVKALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Rhopalosiphum padi)] Sequence ID: P48571.1 Length: 518 Range 1: 1 to 506 Score:146 bits(368), Expect:5e-37, Method:Compositional matrix adjust., Identities:137/527(26%), Positives:237/527(44%), Gaps:35/527(6%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + +++ I D TLRDGEQ S S +KL IA L+ +D +E+ S G+ ++VQ Sbjct 1 MNSQVIIFDTTLRDGEQALQASLSVKQKLQIA-LSLENTGIDIIEVGFPISSPGDFKSVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 I + ++ L D + + + S A +++ S+ H+E +L K + Sbjct 60 TISKNIKNSRICSLARCLD-KDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQI 118 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 ++ A++ + ED S R + D + +VE L ++ I +PDT+G Sbjct 119 IDMAITSVKRALRYTDDVEFSCEDAS---RTTMDNLCRIVEKLINAGVKTINIPDTVGYT 175 Query 184 SPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P E + +L Q+ P+I H HND ++V NS+ AI+AG + + +ING+GER Sbjct 176 VPNELSSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGER 235 Query 241 AGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE ++ I D T I I S+++ I N+ IVG + F Sbjct 236 AGNTALEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAH 295 Query 298 TAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQK 356 ++G+H DG K + P G K L +G+A++ + ++G + + + Sbjct 296 SSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECDYKIDE 355 Query 357 VLERVIELGDQNKLVTPEDLPFIIADVSGRTGE------KVLTIKSCNIHSGIGIRPHAQ 410 + ++L D+ V DL +A ++ + E +++S I +G+ A Sbjct 356 LYASFLKLADKKGQVFDYDLE-ALAFINQQQEELEHFSLSFFSVQS--ISNGLST---AS 409 Query 411 IELEYQGKIHKE-ISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVE 469 ++L K E + +G DA AL +IT+ P ++ I G DAL + Sbjct 410 VKLLCGKKTFIESATTSNGPIDAIYQALNRITH-----FPIILQKYQLIAKGKGKDALGQ 464 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 I L + + F MG+ D ++ A +LN I + Q+ Sbjct 465 VDI-----LVEHKKRKFHGMGLATDIIESSAQAMVNVLNNIWKANQV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Edwardsiella ictaluri 93-146] Sequence ID: C5B7R4.1 Length: 526 Range 1: 7 to 506 Score:146 bits(369), Expect:5e-37, Method:Compositional matrix adjust., Identities:127/519(24%), Positives:235/519(45%), Gaps:31/519(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ +V+ I + Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPISSPGDFASVRAIAQRV 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + ++ L +LH LE +L ++ F D Sbjct 66 KQSRVCALARCVDADIDAAAEALRAADAFRIHTFLATSTLH-LESKLRRS----FDDAIA 120 Query 130 VIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 + +AI L+ Y +D + R D + +VE + + +PDT+G +P Sbjct 121 MARHAI---LRARRYTDDVEFSCEDAGRTPIDNLCRIVEAAIDAGAKTVNIPDTVGYTTP 177 Query 186 EETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 + + +L ++ P+I H H+D ++ ANS+ AI++G + + ++NG+GERAG Sbjct 178 YQFGGIIHTLFERVPNIDKAVISVHCHDDLGMACANSISAIQSGARQVEGTLNGIGERAG 237 Query 243 NTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I + + T I I S+LV I AN+ +VG + F ++ Sbjct 238 NCALEEVIMAIRTRQDLLRVHTGIRHQEIYRTSQLVSQLCNMPIPANKAVVGANAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVL-SEVVLQKV 357 G+H DG K + PE G ++ L +G+A++ ++++G ++ L+++ Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLPQTQLNLTSRSGRAAVKHRMEEMGYCEGNDFDLERL 357 Query 358 LERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQG 417 + + L D+ V DL + + ++ ++ SG + A + L Sbjct 358 YQAFLRLADKKGQVFDYDLEALAFIDRQQEEADHFRLEYFSVQSGSSVMATASVRLICGA 417 Query 418 KIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKS 477 + E + G+G DA A+++IT+ IS+ ++ Y++ G+ DAL + I Sbjct 418 ETRAEAATGNGPVDAVYQAISRITD---ISV-DIVKYQLSAKGQGR-DALGQVDIVAE-- 470 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + + F +G+ D ++ A +LN I + Q+ Sbjct 471 ---HQGRRFHGVGLTTDIVESSAQALIHVLNHIWRARQV 506 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Vibrio vulnificus YJ016] Sequence ID: Q7MP77.1 Length: 515 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Vibrio vulnificus CMCP6] Sequence ID: Q8DEE1.1 Length: 515 Range 1: 7 to 439 Score:146 bits(368), Expect:5e-37, Method:Compositional matrix adjust., Identities:122/451(27%), Positives:206/451(45%), Gaps:37/451(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA + L++L VD +E S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-YALERLGVDVIEAGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A R+ L ++ V+ D+ A+ L + +H H++ +L ++ Sbjct 62 ARNIKNSRVCAL-----SRAVEKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + V+E +++ Y +D + R D + +VE I +P Sbjct 117 D-------VVEMGVRAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G P E + +L + P+I H H+D +SVANS+ A++AG + + +I Sbjct 170 DTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTI 229 Query 235 NGLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGN LE + I + +T IN I S+LV I AN+ IVG Sbjct 230 NGIGERAGNCSLEEIAMIIKTRQELLGVRTGINHEEIHRTSKLVSQLCNMPIQANKAIVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLS 350 + F+ ++G+H DG K + PE G K ++ L +G+A++ ++ +G Sbjct 290 ANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDAMGYKED 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 E L + + ++L D+ V DL ++ + R + + ++ SG + Sbjct 350 EYNLDALYQDFLKLADRKGQVFDYDLEALMHFSNLREEDDYYKLNYLSVQSG-SVMATTS 408 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKIT 441 I+L + E + G+G DA + ++T Sbjct 409 IKLLCGDEEKCEAAVGNGPVDALYQCIYRLT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Uroleucon sonchi)] Sequence ID: Q9EVI8.1 Length: 502 Range 1: 1 to 493 Score:145 bits(367), Expect:6e-37, Method:Compositional matrix adjust., Identities:137/515(27%), Positives:235/515(45%), Gaps:37/515(7%) Query 17 DGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQLTE 76 DGEQ S S EKL IA L+K VD +E+ S G+ ++VQ I + ++ Sbjct 1 DGEQALQASLSVKEKLQIA-LCLEKAGVDIMEVGFPISSPGDFKSVQTISQNIKNSRICS 59 Query 77 RIEILGFVDGNKTVDWIKDSGAKV----LNLLTKGSLHHLEKQLGKTPKEFFTDVSFVIE 132 + K +D ++ + +++ S H+E +L K E F ++ Sbjct 60 LARCI-----EKDIDTAGEAMSHCDFFRIHVFLATSTLHMESKLRKNFDEIIDMAIFSVK 114 Query 133 YAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGV 192 A++ + ED S R + D + +VE L ++ I +PDT+G P E + Sbjct 115 RALRYTDDVEFSCEDAS---RTTMDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSLII 171 Query 193 DSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEAL 249 +L ++ P+IH H HND ++V NS+ AI+AG + + +ING+GERAGNT LE + Sbjct 172 KNLFERVPNIHKSTISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEV 231 Query 250 VTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGD 306 + I D TNIN I S+++ I +N+ IVG + F+ ++G+H DG Sbjct 232 IMAIKVREDILGLSTNINHKEIYRTSQVISRICNMPIPSNKAIVGSNAFSHSSGIHQDGV 291 Query 307 KKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELG 365 K + P G K+ L +G+A++ + ++G S+ + ++ ++L Sbjct 292 LKNRENYEIMDPSSIGLKKVKLNLTSRSGRAAVKYYMNEMGYKDSDYNIDELYVDFLKLA 351 Query 366 DQNKLVTPEDLPFIIADVSGRTGE-KVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEIS 424 D+ V DL +A ++ + E + +K ++ S A + L KI+ E S Sbjct 352 DKKGQVFDYDLE-ALAFINKKQDELEHFCLKFFSVQSISNNLSTASVTLLCGDKIYTESS 410 Query 425 -EGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRITWNKSLDLE 481 +G A AL +IT+ P ++ I G DAL V+ + + K Sbjct 411 TTSNGPVXAIYQALNRITH-----FPIILQKFQLIAKGQGKDALGQVDILVKYKK----- 460 Query 482 EDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + Q+ Sbjct 461 --RQFHGVGLATDIIESSAQAMINVLNNIWKVKQV 493 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli BW2952] Sequence ID: C4ZPZ7.1 Length: 523 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Escherichia coli K-12] Sequence ID: P09151.5 Length: 523 Range 1: 7 to 505 Score:146 bits(368), Expect:6e-37, Method:Compositional matrix adjust., Identities:142/518(27%), Positives:229/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ SG A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITEYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=Homocitrate synthase; Short=HCS [Saccharolobus solfataricus P2] Sequence ID: Q97ZE0.1 Length: 461 Range 1: 3 to 436 Score:145 bits(365), Expect:7e-37, Method:Compositional matrix adjust., Identities:129/449(29%), Positives:221/449(49%), Gaps:26/449(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ ILD TLR+GEQT GV F+ +++ IAK L L V +E VS E +++I+ Sbjct 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAK-ALSDLGVSMIEAGHPAVSPDIYEGIKRIV 61 Query 67 EWAATEQLTERIEILGFVDG-NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 + +T EI+G + ++ + + + S HL+ + T +E Sbjct 62 KLKKEGIITS--EIVGHSRAVKRDIEIAAELEVDRIAIFYGVSDIHLKAKHKATREEALR 119 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 ++ I YA G+K+ ED G R D++ ++ +R+ + DT+G+L P Sbjct 120 VIAETISYARSHGVKVRFTAED---GSRTDFDFLVTVSRTARDAGADRVSIADTVGILYP 176 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 +T + +LI++ P++ ++ H HND L+VAN+L A+ G +HA++NGLGER G P Sbjct 177 SKTKELFSALIREVPNLEYDIHAHNDLGLAVANALAAVEGGATIVHATVNGLGERVGIVP 236 Query 246 LEALVTTIHDKSNSKTNINEI-AITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 L+ +V I K + + ++ + S L+E +SG + N PI G+ F AGVH Sbjct 237 LQQIVAAI--KYHFGIEVVKLDKLQYVSSLIEKYSGIPMPPNYPITGDYAFLHKAGVHVA 294 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 G + PE FGR R Y + K GK ++ + ++LG+ +SE + ++L + I+ Sbjct 295 GVLSDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISEAEMDQILAK-IKS 353 Query 365 GDQNKLVTPEDLPFIIADVSGRTG--------EKVLTIKS-CNIHSGIGIRPHAQIELEY 415 + DL + +V+GR E ++++K N+++ R + I Sbjct 354 NTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEALISVKCDSNVYTTSVTRRLSVI---- 409 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRL 444 G KE+ E G YD + K +N L Sbjct 410 NGV--KEVMEISGDYDILVKVQAKDSNEL 436 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola BCc] Sequence ID: Q5WQ01.1 Length: 516 Range 1: 4 to 507 Score:145 bits(367), Expect:7e-37, Method:Compositional matrix adjust., Identities:141/524(27%), Positives:241/524(45%), Gaps:34/524(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I D TLRDGEQ S +++EK+ IA L++L VD +E+ S G+ ++VQ + Sbjct 4 KIIIFDTTLRDGEQALLTSLTSNEKIQIA-LALERLGVDVIEVGFPVSSPGDFKSVQMLS 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + ++ L D D ++ S ++L S H+ +L K E Sbjct 63 KIIKNSKICSLARCLP-NDITIAADAMQFSKNFRIHLFLGTSDLHVSSKLKKNFNE---- 117 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 +IE A+ S + + D + R + + ++E + K + +PDT+G Sbjct 118 ---IIEMAVASVKQAKKFTNDIEFSCEDAGRTTLQNLYCIIEAVIKAGATTVNIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 +P + + + L +IH H HND ++VANS+ A+ AGV+ + ++NGLGE Sbjct 175 TTPTQFKKIITMLFNHVKNIHQAIISVHCHNDLGMAVANSISAVEAGVRQIEGTMNGLGE 234 Query 240 RAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE ++ T++ NS T+IN I S++V F I N+ I+G++VF+ Sbjct 235 RAGNAALEEVIMTLNVHKNSLKVSTDINIKEIHRTSKIVSQFCNTPIPLNKAIIGKNVFS 294 Query 297 QTAGVHADGDKKGNLYANPILPERFGRK--RSYALGKLAGKASISENVKQLGMVLSEVVL 354 ++G+H DG K I P G S L +G+A++ ++K++G S+ L Sbjct 295 HSSGIHQDGVLKNRKNYEIIDPNSIGFTDYCSLNLTSRSGRAAVKHHMKKMGYENSDYNL 354 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 ++ ++L D+ + DL + + E+ ++ ++ S + A I L Sbjct 355 NELYIDFLKLADKKGRIFDYDLEALAFFKKQQNTEEYYKLEYFDVQSKLSGLSTAYIVLI 414 Query 415 Y--QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRI 472 Q I K + +G DA AL K T I + K + + GK DAL + I Sbjct 415 CGSQTNIQKATTY-NGPVDAIYQALNKAT-LYSIVLKK---FHLEANGEGK-DALGKVNI 468 Query 473 TWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 L + F +G+ D A+ A +LN I + Q+ Sbjct 469 IVQYKL-----RNFHGVGLATDIIEASAQAMVNVLNYIWKSQQV 507 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aeromonas salmonicida subsp. salmonicida A449] Sequence ID: A4SR62.1 Length: 524 Range 1: 4 to 505 Score:146 bits(368), Expect:7e-37, Method:Compositional matrix adjust., Identities:138/527(26%), Positives:230/527(43%), Gaps:42/527(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S + EKL IA+ L++L VD +E+ S G+ ++VQ I Sbjct 4 RVIIFDTTLRDGEQALAASLTVKEKLQIAQ-ALERLGVDIMEVGFPVSSPGDFQSVQTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 ++ L D + + ++ + A ++ S H+E +L K+ F D Sbjct 63 RHIKNSRVCALARALP-QDIDAAGEALRVAEAFRIHTFISTSSIHVESKLKKS----FED 117 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V + AIK L+ Y +D + R D + +VE K I +PDT+G Sbjct 118 VLEMGVSAIKHALR---YTDDVEFSCEDAGRTPIDNLCRMVEAAIKAGARTINIPDTVGY 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P E + +L + P+I H H+D LSVANS+ A++ G + + +ING+GE Sbjct 175 TVPTEFSGIIQTLFNRVPNIDKAIISVHCHDDLGLSVANSIGAVQMGARQIECTINGIGE 234 Query 240 RAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGN LE + + +++ TNI I S LV + N+ IVG + F+ Sbjct 235 RAGNCSLEEVAMILKTRADLLGVHTNIRHSEIHRTSALVSQLCNMPVQPNKAIVGANAFS 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 ++G+H DG K I PE G + + + +G+ I ++ +G S L Sbjct 295 HSSGIHQDGVLKAKNTYEIITPESIGLPQNNLNMTSRSGRHVIKHRMESMGYAESSYDLD 354 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 + + + L D+ V DL + + ++ + SG + A ++L+ Sbjct 355 HLYGKFLTLADKKGQVFDYDLEALAFFSQIHEEPEHFKLEYLGVQSGSSVLATASVKLKV 414 Query 416 QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRI------PPGGKTDALVE 469 + E + G+G DA + +IT YE+RI G +AL + Sbjct 415 GQDLVCEAATGNGPVDAVYQCINRITG-----------YEIRIDKYALKAKGEGKNALGQ 463 Query 470 TRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 I + + F MG+ D ++ A ++N I + Q+ Sbjct 464 VDIVAEY-----KGRKFHGMGLATDIIESSAQALIHVINSIWRADQV 505 >RecName: Full=2-isopropylmalate synthase A; AltName: Full=Alpha-IPM synthase A; AltName: Full=Alpha-isopropylmalate synthase A [Solanum pennellii] Sequence ID: O04973.1 Length: 589 Range 1: 48 to 571 Score:146 bits(369), Expect:1e-36, Method:Compositional matrix adjust., Identities:143/545(26%), Positives:244/545(44%), Gaps:62/545(11%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ+ G + +T EKL++A+ L KL VD +E S+ + E+V+ I Sbjct 48 VRIFDTTLRDGEQSPGATMTTKEKLDVAR-QLAKLGVDIIEAGFPASSEADFESVKLI-- 104 Query 68 WAATEQLTERIEILGFV------------DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 E++ + GFV D +K + +K + ++ S H++ + Sbjct 105 ---AEEIGNNTDENGFVPVICGLSRCNKSDIDKAWEAVKYAKKPRVHTFIATSEIHMKYK 161 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERI 174 L + ++ ++ YA G + + ED R+ +++ ++ + K + Sbjct 162 LKMSREQVVEKARSMVAYARSLGCEDVEFSPEDAG---RSDREFLYDILGEVIKAGATTL 218 Query 175 FLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLH 231 +PDT+G P E Q + + P I H ND LS AN+L AG + L Sbjct 219 NIPDTVGYTVPSEFGQLITDIKANTPGIENVIISTHCQNDLGLSTANTLAGACAGARQLE 278 Query 232 ASINGLGERAGNTPLEALVTTIHDKSNS-----KTNINEIAITEASRLVEVFSGKRISAN 286 +ING+GERAGN LE +V + + T IN I +S++VE +SG ++ + Sbjct 279 VTINGIGERAGNASLEEVVMALKCRGEQVLGGLYTGINTQHIVPSSKMVEEYSGLQVQPH 338 Query 287 RPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENV 342 + IVG + F +G+H DG K I P+ G RS LGKL+G+ ++ + Sbjct 339 KAIVGANAFAHESGIHQDGMLKHKDTYEIISPDDVGLSRSNEAGIVLGKLSGRHALKSKM 398 Query 343 KQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIAD------VSGRTGEKVLTIKS 396 +LG + L+ + R + ++ K +T +DL +++D V + G+ + S Sbjct 399 LELGYDIDGKELEDLFWRFKSVAEKKKKITDDDLIALMSDEVLQPNVYWKLGDVQIMCGS 458 Query 397 CNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYE 455 +G+ + G+ H S G G DA A+ I + +P L++Y Sbjct 459 ------LGLSTATVKLINTDGQEHIACSVGTGPVDAAYKAVDLI-----VKVPITLLEYS 507 Query 456 VRIPPGGKTDALVETRIT---------WNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKM 506 + G DA+ TR++ N S +TF G D +++V A Sbjct 508 MNAVTEG-IDAIASTRVSICSIDRHTIMNGSTGQTIHRTFSGTGADMDVVISSVRAYIGA 566 Query 507 LNQIL 511 LN++L Sbjct 567 LNKML 571 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Enterobacter sp. 638] Sequence ID: A4W6H9.1 Length: 523 Range 1: 7 to 505 Score:145 bits(366), Expect:1e-36, Method:Compositional matrix adjust., Identities:134/516(26%), Positives:231/516(44%), Gaps:26/516(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAVY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +I+ A + ED R + +VE + I +PDT+G P E Sbjct 125 MIKRARHYTDDVEFSCEDAG---RTPIADLARVVEAAINAGAKTINIPDTVGYTMPFEFS 181 Query 190 QGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + L ++ P+I H H+D L+V N++ A+ AG + + ++NG+GERAGN L Sbjct 182 NIITGLYERVPNIDQAIISVHTHDDLGLAVGNAIAAVHAGARQVEGAMNGIGERAGNCSL 241 Query 247 EALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 E ++ I D N +T IN I S+ V I AN+ IVG F ++G+H Sbjct 242 EEVIMAIKVRKDIMNVQTRINHNEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQ 301 Query 304 DGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVI 362 DG K + PE G + L +G+A++ ++++G ++ + + + + Sbjct 302 DGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYKETDYNMDHLYDAFL 361 Query 363 ELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKE 422 +L D+ V DL I + + + ++ SG A ++L +I E Sbjct 362 KLADKKGQVFDYDLEAIAFINKQQEEPEHFRMDYFSVQSGSSDIATASVKLACGDEIKAE 421 Query 423 ISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRITWNKSLDL 480 + G+G DA A+ ++T G + +L+ Y++ GK DAL V+ +T+N Sbjct 422 AANGNGPVDAIYQAINRVT---GYDV-ELVKYDLSAKGHGK-DALGQVDIVVTYN----- 471 Query 481 EEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 --GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aliivibrio fischeri MJ11] Sequence ID: B5FGH4.1 Length: 515 Range 1: 7 to 439 Score:145 bits(365), Expect:1e-36, Method:Compositional matrix adjust., Identities:118/443(27%), Positives:204/443(46%), Gaps:21/443(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA + L++L VD +E S G+ E+V+ I + Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-YALERLGVDVIEAGFPVSSPGDFESVRTIAQHI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + + +K + A ++ S H++ +L ++ + Sbjct 66 KNSRICGLSRAVA-KDIDAAAEALKVAEAFRIHTFISTSTVHVQDKLRRSYDD------- 117 Query 130 VIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 V+E +K+ Y +D + R D + +VE I +PDT+G P Sbjct 118 VVEMGVKAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGANTINIPDTVGYTVP 177 Query 186 EETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E V +L + P+I H H+D +SVANS+ A++AG + + +ING+GERAG Sbjct 178 GEFGGIVQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAG 237 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE + + +S TN+ I S+LV I +N+ IVG + F+ ++ Sbjct 238 NCSLEEIAMILKTRSEYLGVHTNLKHDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G K ++ L +G+A++ ++ ++G E L + Sbjct 298 GIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDEMGYKEDEYNLDTLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 ++L D+ V DL ++ + R + + ++ SG + I+L + Sbjct 358 ADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSG-SVMATTSIKLLCGDE 416 Query 419 IHKEISEGDGGYDAFMNALTKIT 441 E + G+G DA + K+T Sbjct 417 EKCEAAVGNGPVDALYQCIYKLT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Aliivibrio fischeri ES114] Sequence ID: Q5E856.1 Length: 515 Range 1: 7 to 439 Score:144 bits(364), Expect:2e-36, Method:Compositional matrix adjust., Identities:118/443(27%), Positives:204/443(46%), Gaps:21/443(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA + L++L VD +E S G+ E+V+ I + Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-YALERLGVDVIEAGFPVSSPGDFESVKTIAQHI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + + +K + A ++ S H++ +L ++ + Sbjct 66 KNSRICGLSRAVA-KDIDAAAEALKVAEAFRIHTFISTSTVHVQDKLRRSYDD------- 117 Query 130 VIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 V+E +K+ Y +D + R D + +VE I +PDT+G P Sbjct 118 VVEMGVKAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAIDAGANTINIPDTVGYTVP 177 Query 186 EETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E V +L + P+I H H+D +SVANS+ A++AG + + +ING+GERAG Sbjct 178 GEFGGIVQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAG 237 Query 243 NTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE + + +S TN+ I S+LV I +N+ IVG + F+ ++ Sbjct 238 NCSLEEIAMILKTRSEYLGVHTNLKHDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G K ++ L +G+A++ ++ ++G E L + Sbjct 298 GIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDEMGYKEDEYNLDTLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 ++L D+ V DL ++ + R + + ++ SG + I+L + Sbjct 358 ADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSG-SVMATTSIKLLCGDE 416 Query 419 IHKEISEGDGGYDAFMNALTKIT 441 E + G+G DA + K+T Sbjct 417 EKCEAAVGNGPVDALYQCIYKLT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Haemophilus influenzae 86-028NP] Sequence ID: Q4QLS4.1 Length: 515 Range 1: 4 to 441 Score:144 bits(364), Expect:2e-36, Method:Compositional matrix adjust., Identities:129/455(28%), Positives:204/455(44%), Gaps:37/455(8%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S+G+ E+VQ I Sbjct 4 RVIIFDTTLRDGEQALKASLTVKEKLQIA-LALERLGVDVMEVGFPVSSQGDFESVQTI- 61 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGK 118 A R+ L ++ VD D+ + L + +H H+E +L Sbjct 62 ---ARHIKNARVAAL-----SRAVDKDIDAAYQALKVAEAFRIHTFIASSALHVEAKL-- 111 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERI 174 K F DV + A+K + Y +D + R D + +VE + Sbjct 112 --KRSFDDVVGMAVAAVK---RARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTV 166 Query 175 FLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLH 231 +PDT+G P E + + + P+I H HND ++ ANSL A++ G + + Sbjct 167 NIPDTVGFCLPNEYGNIIAQVRNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIE 226 Query 232 ASINGLGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRP 288 +ING+GERAGNT LE +V + D T IN I S++V I N+ Sbjct 227 CTINGIGERAGNTSLEEVVMAMKVRQDFMGVDTRINTQEIHRVSQMVSQLCNMPIQPNKA 286 Query 289 IVGEDVFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGM 347 IVG + F ++G+H DG K + PE G +K L +G+A++ ++ +G Sbjct 287 IVGSNAFAHSSGIHQDGMLKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKGHMADMGY 346 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRP 407 + L K+ + ++L D+ V DL + + E L + + HS Sbjct 347 NEQDYDLDKLYDAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPA 406 Query 408 HAQIELEYQG-KIHKEISEGDGGYDAFMNALTKIT 441 A ++L+ G K+ G+G DA NA+ +T Sbjct 407 TAFVQLKLDGEKLSTSSIGGNGPVDAVYNAILNLT 441 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shigella dysenteriae Sd197] Sequence ID: Q32K20.1 Length: 523 Range 1: 7 to 505 Score:144 bits(363), Expect:3e-36, Method:Compositional matrix adjust., Identities:141/518(27%), Positives:229/518(44%), Gaps:30/518(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AIYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPF 178 Query 187 ETFQGVDS-LIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAG 242 E F G+ S L ++ P+I H H+D L+V NSL A+ AG + + ++NG+GERAG Sbjct 179 E-FAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAG 237 Query 243 NTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTA 299 N LE ++ I D N T IN I S+LV I AN+ IVG F ++ Sbjct 238 NCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSS 297 Query 300 GVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVL 358 G+H DG K + PE G + L +G+A++ + ++G SE L + Sbjct 298 GIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLY 357 Query 359 ERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGK 418 + ++L D+ V DL + + + + ++ S A ++L + Sbjct 358 DAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSSSNDIATAAVKLACGEE 417 Query 419 IHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSL 478 + E + G+G DA A+ +IT+ +L+ Y + GK DAL + I N + Sbjct 418 VKAEAANGNGPVDAVYQAINRITDYN----VELVKYSLTAKGHGK-DALGQVDIVANYN- 471 Query 479 DLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 ----GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Haemophilus influenzae PittEE] Sequence ID: A5UD85.1 Length: 515 Range 1: 4 to 441 Score:144 bits(363), Expect:3e-36, Method:Compositional matrix adjust., Identities:126/447(28%), Positives:202/447(45%), Gaps:21/447(4%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S+G+ E+VQ I Sbjct 4 RVIIFDTTLRDGEQALKASLTVKEKLQIA-LALERLGVDVMEVGFPVSSQGDFESVQTIA 62 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 ++T + D + + +K + A ++ S H+E +L K F D Sbjct 63 RHIKNARVTALSRAVD-KDIDAAYEALKVAEAFRIHTFIASSALHVEAKL----KRSFDD 117 Query 127 VSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGV 182 V + A+K Y +D + R D + +VE + +PDT+G Sbjct 118 VVGMAVAAVKRARN---YTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGF 174 Query 183 LSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 P E + + + P+I H HND ++ ANSL A++ G + + +ING+GE Sbjct 175 CLPNEYGNIIAQVRNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGE 234 Query 240 RAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 RAGNT LE +V + D T IN I S++V I N+ IVG + F Sbjct 235 RAGNTSLEEVVMAMKVRQDFMGVDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFA 294 Query 297 QTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEVVLQ 355 ++G+H DG K + PE G +K L +G+A++ ++ +G + L Sbjct 295 HSSGIHQDGMLKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYDLD 354 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEY 415 K+ + ++L D+ V DL + + E L + + HS A ++L+ Sbjct 355 KLYDAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQLKL 414 Query 416 QG-KIHKEISEGDGGYDAFMNALTKIT 441 G K+ G+G DA NA+ +T Sbjct 415 DGNKLITSSIGGNGPVDAVYNAILNLT 441 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Haemophilus influenzae Rd KW20] Sequence ID: P43861.1 Length: 515 Range 1: 4 to 441 Score:144 bits(362), Expect:3e-36, Method:Compositional matrix adjust., Identities:127/450(28%), Positives:205/450(45%), Gaps:27/450(6%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI- 65 R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S+G+ E+VQ I Sbjct 4 RVIIFDTTLRDGEQALKASLTVKEKLQIA-LALERLGVDVMEVGFPVSSQGDFESVQTIA 62 Query 66 --MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 ++ A L+ ++ D + + +K + A ++ S H+E +L K Sbjct 63 RHIKNARVAALSRAVD----KDIDAAYEALKVAEAFRIHTFIASSALHVEAKL----KRS 114 Query 124 FTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 F DV + A+K Y +D + R D + +VE + +PDT Sbjct 115 FDDVVGMAVAAVKRARN---YTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDT 171 Query 180 LGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G P E + + P+I H HND ++ ANSL A++ G + + +ING Sbjct 172 VGFCLPNEYGNIIAQVRNCVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTING 231 Query 237 LGERAGNTPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 +GERAGNT LE +V + D T+IN I S++V I N+ IVG + Sbjct 232 IGERAGNTSLEEVVMAMKVRQDFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGSN 291 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFG-RKRSYALGKLAGKASISENVKQLGMVLSEV 352 F ++G+H DG K + PE G +K L +G+A++ ++ +G + Sbjct 292 AFAHSSGIHQDGMLKNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDY 351 Query 353 VLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIE 412 L K+ + ++L D+ V DL + + E L + + HS A ++ Sbjct 352 DLDKLYDEFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQ 411 Query 413 LEYQG-KIHKEISEGDGGYDAFMNALTKIT 441 L+ G K+ G+G DA NA+ +T Sbjct 412 LKLDGEKLSTSSIGGNGPVDAVYNAILNLT 441 >RecName: Full=Homocitrate synthase 2 [Nostoc sp. PCC 7120 = FACHB-418] Sequence ID: P58637.1 Length: 376 Range 1: 6 to 347 Score:141 bits(355), Expect:4e-36, Method:Compositional matrix adjust., Identities:109/358(30%), Positives:172/358(48%), Gaps:22/358(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ GV+FS EK+ IAKFL + V +E+ + K E E + I+ Sbjct 6 INDTTLRDGEQAAGVAFSVEEKIAIAKFL-DAIGVHEIEVGIPAMGKAEQEAIANIV--- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKD------SGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 +L +LG+ N+ V I D G + +++ S + + + Sbjct 62 ---KLDLSANLLGW---NRAV--IADIQASIACGLQRVHISIPVSAIQIAVKFHGQWQVV 113 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 + I +A+ GL +++ ED S R ++ +V + R DT+G+L Sbjct 114 LQKLHDSISFAVDQGLFVSIGGEDSS---RAEESFLLDVVLAAQEWGASRFRFCDTVGIL 170 Query 184 SPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 P T V L+ I E H HND+ L+ AN+L +AG ++ ++NGLGERAGN Sbjct 171 DPFTTHAKVKQLVASLT-IPVEMHTHNDFGLATANALAGTKAGALSVNTTVNGLGERAGN 229 Query 244 TPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 LE +V + + I+ + E S+LV SG + + IVGE+ F +G+HA Sbjct 230 AALEEVVMALKHLYHHDLGIDTRRLLEISQLVASASGHPVPPWKAIVGENTFAHESGIHA 289 Query 304 DGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 G + P PE GR+R +GK +G+ +S ++Q ++L+ Q VL+ V Sbjct 290 HGVLQNPQTYEPFAPEEVGRERRLVVGKHSGRHLLSSILQQHDIILNHEETQFVLDAV 347 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Klebsiella pneumoniae subsp. pneumoniae MGH 78578] Sequence ID: A6T4L9.1 Length: 523 Range 1: 7 to 505 Score:143 bits(361), Expect:5e-36, Method:Compositional matrix adjust., Identities:135/514(26%), Positives:227/514(44%), Gaps:22/514(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +++ A + ED R + +VE I +PDT+G P E Sbjct 125 MVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPFEYA 181 Query 190 QGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + L + P+I H H+D ++V N+L A+ AG + + ++NG+GERAGN L Sbjct 182 NIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCAL 241 Query 247 EALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 E ++ I D N TNIN I S+ V I AN+ IVG F ++G+H Sbjct 242 EEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQ 301 Query 304 DGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVI 362 DG K + PE G + L +G+A++ ++++G S+ L + + + Sbjct 302 DGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAFL 361 Query 363 ELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKE 422 +L D+ V DL + + + + N+ SG A I+L +I E Sbjct 362 KLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFNVQSGSSDIATASIKLVCGDEIKTE 421 Query 423 ISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEE 482 + G+G DA A+ ++T+ +I +L+ Y + GK DAL + I + + Sbjct 422 AANGNGPVDAIYQAINRVTD---YNI-ELVKYGLSAKGHGK-DALGQVDIVVDYN----- 471 Query 483 DQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 GRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas campestris pv. campestris str. B100] Sequence ID: B0RP28.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas campestris pv. campestris str. ATCC 33913] Sequence ID: P58901.1 Length: 520 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Xanthomonas campestris pv. campestris str. 8004] Sequence ID: Q4UYG1.1 Length: 520 Range 1: 12 to 444 Score:143 bits(361), Expect:5e-36, Method:Compositional matrix adjust., Identities:122/442(28%), Positives:203/442(45%), Gaps:17/442(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ+ G S + +KL +A+ L L VD +E S + E V + Sbjct 12 IRIFDTTLRDGEQSPGCSMTPQQKLVMAR-ALDALGVDIIETGFPASSYSDREAVAMMGR 70 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 L L D + ++ + L++ S H E +L + ++ V Sbjct 71 ELRRPTLAVLSRCLQ-ADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESV 129 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 + A I ED + R D++ + I LPDT+G +PEE Sbjct 130 HKHVTLARGYIDDIEFSAEDAT---RTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEE 186 Query 188 ---TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 F + + ++ + F H HND L+ ANSL AI G + + +ING+GERAGN Sbjct 187 IRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNC 246 Query 245 PLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 LE + + + N T IN I S+L++ G + N+ +VG + F +G+ Sbjct 247 ALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGI 306 Query 302 HADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQKVLER 360 H G + + PE G + S LG+ +G+A++ + ++ LG +L E + V E+ Sbjct 307 HQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQ 366 Query 361 VIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIEL-EYQGKI 419 L ++ ++VT DL ++ D + + G ++ ++ S +G R +A +EL + G Sbjct 367 FKALCEKQRVVTDADLQALMQDATVQEGYRLASMTI----SDVGSRANALVELSDPDGNR 422 Query 420 HKEISEGDGGYDAFMNALTKIT 441 E ++G+G DA AL T Sbjct 423 VAETAQGNGPVDALFGALASAT 444 >RecName: Full=2-phosphonomethylmalate synthase [Streptomyces rubellomurinus] Sequence ID: Q0ZQ46.1 Length: 373 Range 1: 9 to 351 Score:140 bits(353), Expect:6e-36, Method:Compositional matrix adjust., Identities:98/353(28%), Positives:175/353(49%), Gaps:10/353(2%) Query 12 DVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAAT 71 D TLRDGEQT GV+FS K I L++ V +EI + EL+ ++ +++ Sbjct 9 DTTLRDGEQTPGVAFSKETKTAILNALIEA-GVTSIEIGIPAMGGEELDFIKSVVDRQDE 67 Query 72 EQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSFVI 131 +L ++ + V+ D G +++ S HL+ + K ++ Sbjct 68 ARL-----VVWHRGVREDVERSLDLGFTSVHVGLPTSAGHLKASVRKDRTWLLATARDMV 122 Query 132 EYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQG 191 + A G +++ ED + R +++ +++ +R+ L DT+G+L PE + Sbjct 123 KMAKDRGAFVSISAEDIA---RTEISFLQEYAGVVAEAGADRLRLSDTVGLLGPEAYGER 179 Query 192 VDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVT 251 V +++ DI + H HND+ L+ AN+L ++AG + H ++N +GERAG L +V Sbjct 180 VAAVLSA-ADIDVQCHAHNDFGLATANTLAGLKAGARYFHVTVNAIGERAGMADLAQVVV 238 Query 252 TIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNL 311 + + I+ + + SRLV +G ++ +PI G++VF +G+HA+G + Sbjct 239 ALKKLYDRDLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNVFAHESGIHANGMFRDTS 298 Query 312 YANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 P PE G +R Y LGK +G+A ++ ++Q G+ E +L LE V L Sbjct 299 SFEPFPPEHVGGERRYVLGKHSGRALVAWALEQEGITPREELLPHCLEEVRAL 351 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Klebsiella variicola 342] Sequence ID: B5Y1W2.1 Length: 523 Range 1: 7 to 505 Score:143 bits(360), Expect:7e-36, Method:Compositional matrix adjust., Identities:136/516(26%), Positives:226/516(43%), Gaps:26/516(5%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQSIARTI 65 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 ++ + D + + +K + A ++ S H+ +L T E + Sbjct 66 KNSRVCALARCVE-KDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIY 124 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 +++ A + ED R + +VE I +PDT+G P E Sbjct 125 MVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTMPFEYA 181 Query 190 QGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + L + P+I H H+D ++V N+L A+ AG + + ++NG+GERAGN L Sbjct 182 NIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCAL 241 Query 247 EALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 E ++ I D N TNIN I S+ V I AN+ IVG F ++G+H Sbjct 242 EEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQ 301 Query 304 DGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVI 362 DG K + PE G + L +G+A++ ++++G S+ L + + + Sbjct 302 DGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAFL 361 Query 363 ELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKE 422 +L D+ V DL + + + + ++ SG A I+L +I E Sbjct 362 KLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASIKLVCGDEIKTE 421 Query 423 ISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRITWNKSLDL 480 + G+G DA A+ ++TN I L+ Y + GK DAL V+ + +N Sbjct 422 AANGNGPVDAIYQAINRVTN-YNID---LVKYGLSAKGHGK-DALGQVDIVVDYNG---- 472 Query 481 EEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 473 ---RRFHGVGLATDIVESSAKAMVHVLNNIWRAAEV 505 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella pealeana ATCC 700345] Sequence ID: A8H9A1.1 Length: 523 Range 1: 1 to 498 Score:143 bits(360), Expect:8e-36, Method:Compositional matrix adjust., Identities:135/521(26%), Positives:230/521(44%), Gaps:39/521(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLTVKEKLQIA-LALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----AKTIKNSRVCAL-----SRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE K I Sbjct 111 LKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEEAIKAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + + + +T IN I S LV + AN+ I Sbjct 228 TVNGIGERAGNCSLEEIAMILSTRKGELGLETGINAKEIHRTSSLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I + +LG Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMSELGYG 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHS-GIGIRP 407 + + + E + L D+ V DL + + + ++ +HS Sbjct 348 EQDYNMDVLYEEFLTLADKKGQVFDYDLEALAFMEAQAETDDHYKLQQLVVHSDSTEGSA 407 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 A +++ G+ E + G+G DA A+ + + G I + Y++ G+ +AL Sbjct 408 TATVKVAVNGETITEAATGNGPVDAAYKAVARAS---GCEI-NISSYQLSAKGEGQ-NAL 462 Query 468 VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLN 508 + IT +Q F +G+ D A+ A ++N Sbjct 463 GQVDITAKY-----REQNFHGVGLATDVVEASAKALVHVMN 498 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Shewanella halifaxensis HAW-EB4] Sequence ID: B0TQM0.1 Length: 523 Range 1: 1 to 441 Score:142 bits(359), Expect:1e-35, Method:Compositional matrix adjust., Identities:120/454(26%), Positives:203/454(44%), Gaps:29/454(6%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 + R+ I D TLRDGEQ S + EKL IA L++L VD +E+ S G+ E+VQ Sbjct 1 MSNRVIIFDTTLRDGEQALAASLTVKEKLQIA-LALERLGVDVMEVGFPVSSPGDFESVQ 59 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQ 115 I A R+ L ++ ++ D+ A+ L++ + +H H+E + Sbjct 60 TI----AKTIKNSRVCAL-----SRALESDIDAAAQALSVAEQFRIHTFISTSTIHVENK 110 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L ++ + ++YA + + ED R D + +VE K I Sbjct 111 LKRSFDQVLDMAVGAVKYARRFTDDVEFSCEDAG---RTPIDNLCRMVEEAIKAGARTIN 167 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +PDT+G P E + +L + P+I H H+D LSVANS+ A++ G + + Sbjct 168 IPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIEC 227 Query 233 SINGLGERAGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPI 289 ++NG+GERAGN LE + + + +T IN I S LV + AN+ I Sbjct 228 TVNGIGERAGNCSLEEIAMILSTRKGELGLETGINAKEIHRTSSLVSQLCNMPVQANKAI 287 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMV 348 VG + FT ++G+H DG K + PE G R + + +G+ I + +LG Sbjct 288 VGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMSELGYG 347 Query 349 LSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHS-GIGIRP 407 + + + E + L D+ V DL + + + ++ +HS Sbjct 348 EQDYDMDVLYEEFLALADKKGQVFDYDLEALAFMEAQAEDDDHFELQQLVVHSDSTEGSA 407 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKIT 441 A +++ G+ E + G+G DA A+ + + Sbjct 408 TATVKVAVNGETITEAATGNGPVDAAYKAVARAS 441 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Paenibacillus sp. Y412MC10] Sequence ID: D3EBC1.1 Length: 518 Range 1: 1 to 462 Score:142 bits(358), Expect:1e-35, Method:Compositional matrix adjust., Identities:125/478(26%), Positives:228/478(47%), Gaps:34/478(7%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ 63 +E + +LD TLRDGEQ G + +K+ A+ L++LNVD +E S G+ + VQ Sbjct 1 MERNIIVLDTTLRDGEQVPGAKLNVQQKIEFAQ-QLKRLNVDIIEAGFPASSAGDFQAVQ 59 Query 64 KIMEWAATEQLTERIEILGFV-----DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGK 118 +I + + + I D + + IK + +++++ S H+EK+ + Sbjct 60 EI-----ARTVGDSVSITALARAVKGDIDAVYESIKLAQNPLIHIVLGTSNIHVEKKFNR 114 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 + ++YA ++ ED S R+ +Y+ +E + K I +PD Sbjct 115 SKDAVLQMGVDAVKYAKTLLPQVQYSTEDAS---RSDFEYLWKTIEAVVKAGATMINVPD 171 Query 179 TLGVLSPEETFQGVDSLIQKYPDIH----FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 T+G P+E + + + ++ +++ H HND L+ AN+L A+R G + + +I Sbjct 172 TVGYAVPDEFGELIRKINERLKNLNDQVILSVHCHNDLGLATANTLSAVRNGAEKVECTI 231 Query 235 NGLGERAGNTPLEALVTTIHDKSN---SKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NGLGERAGNT LE +V + + N + TN+ + SRL+ +G + N+ I G Sbjct 232 NGLGERAGNTSLEEVVMGLKVRENHFKASTNVRLKELIRTSRLLTHLTGLDVQVNKAITG 291 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENVKQLGMVLS 350 E+ F ++G+H DG K + PE G L +G+ + V++LG Sbjct 292 ENAFAHSSGIHQDGLLKDKQVYEIMSPEEVGADSMELILTARSGRHAFKNAVEKLGFETG 351 Query 351 E-VVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLT----IKSCNIHSGIGI 405 E + + E+ + L D K V D+ +++ RT E+V + + S + + + Sbjct 352 EGDDFEALFEKFLLLADAKKEVYDHDVFYLV--TQHRTHEEVSSHLYELDSFQVVTN-DM 408 Query 406 RPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGK 463 P A ++L+ + ++ GDG DA +A+ + +G+ + +L DY++ GK Sbjct 409 YPTATVKLKKGSETFRDSMVGDGPIDALYSAIKAL---VGLDV-QLKDYKINSLSRGK 462 >RecName: Full=2-isopropylmalate synthase B; AltName: Full=Alpha-IPM synthase B; AltName: Full=Alpha-isopropylmalate synthase B [Solanum pennellii] Sequence ID: O04974.1 Length: 612 Range 1: 71 to 594 Score:143 bits(360), Expect:2e-35, Method:Compositional matrix adjust., Identities:144/535(27%), Positives:239/535(44%), Gaps:42/535(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ+ G + +T EKL++A+ KL VD +E S+ +LE V+ I + Sbjct 71 VRIFDTTLRDGEQSPGATMTTKEKLDVAR-QSAKLGVDIIEAGFPASSEADLEAVKLIAK 129 Query 68 WAATEQLTERIE--ILGFVDGNKT-VD--W--IKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 E I G NK +D W +K + ++ S H+ +L + Sbjct 130 EVGNGVYEEEYVPVICGLARCNKKDIDKAWEAVKYAKKPRIHTFIATSEVHMNYKLKMSR 189 Query 121 KEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDT 179 + ++ YA G + + ED R+ P+++ ++ + K + +PDT Sbjct 190 DQVVEKARSMVAYARSIGCEDVEFSPEDAG---RSDPEFLYHILGEVIKAGATTLNIPDT 246 Query 180 LGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 +G PEE Q + + P D+ H ND LS AN+L AG + L +ING Sbjct 247 VGYTVPEEFGQLIAKIKANTPGVEDVIISTHCQNDLGLSTANTLAGACAGARQLEVTING 306 Query 237 LGERAGNTPLEALVTTIHDKSNS-----KTNINEIAITEASRLVEVFSGKRISANRPIVG 291 +GERAGN LE +V + + T IN I +S++VE SG + ++ IVG Sbjct 307 IGERAGNASLEEVVMALKCRGEQVLGGLYTGINTQHILMSSKMVEGISGLHVQPHKAIVG 366 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKRS----YALGKLAGKASISENVKQLGM 347 + F +G+H DG K I PE G R+ GKL+G + +LG Sbjct 367 ANAFVHESGIHQDGMLKHKDTYEIISPEDIGLNRANESGIVFGKLSGVMLCKPKMLELGY 426 Query 348 VLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSG-IGIR 406 + L + R + ++ K +T +DL +++D + + V +++ + G +G+ Sbjct 427 EIEGKELDDLFWRFKSVAEKKKKITDDDLVALMSDEVFQP-QFVWQLQNVQVTCGSLGLS 485 Query 407 PHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP-KLIDYEVRIPPGGKTD 465 ++ G+ H S G G DA A+ I + +P L++Y + G D Sbjct 486 TATVKLIDADGREHISCSVGTGPVDAAYKAVDLI-----VKVPVTLLEYSMNAVTQG-ID 539 Query 466 ALVETRI--------TWNKSLDLEE-DQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 A+ TR+ T +L E +TF G D +++V A LN+++ Sbjct 540 AIASTRVLIRGENGHTSTHALTGETVHRTFSGTGADMDIVISSVRAYVGALNKMM 594 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Vibrio parahaemolyticus RIMD 2210633] Sequence ID: Q87SS7.1 Length: 515 Range 1: 7 to 439 Score:141 bits(355), Expect:3e-35, Method:Compositional matrix adjust., Identities:119/451(26%), Positives:203/451(45%), Gaps:37/451(8%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S + EKL IA + L++L VD +E S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALSASLTVKEKLQIA-YALERLGVDVIEAGFPISSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--------HLEKQLGKTPK 121 A R+ L ++ V D+ A+ L + + +H H++ +L ++ Sbjct 62 AKHIKNSRVCAL-----SRAVAKDIDAAAEALKVADQFRIHTFLATSTIHVQDKLRRSYD 116 Query 122 EFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + V+E A+ + Y +D + R D + +VE I +P Sbjct 117 D-------VLEMAVNAVKHARNYTDDVEFSCEDAGRTPIDNLCRMVEAAIDAGASTINIP 169 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 DT+G P E + +L + P+I H H+D +SVANS+ A++AG + + +I Sbjct 170 DTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQIEGTI 229 Query 235 NGLGERAGNTPLEALVTTIHDKS---NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 NG+GERAGN LE + I + T I I S+LV I +N+ +VG Sbjct 230 NGIGERAGNCSLEEIAMIIKTRQELLGVSTGIKHEEIHRTSKLVSQLCNMPIQSNKAVVG 289 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRK-RSYALGKLAGKASISENVKQLGMVLS 350 + F+ ++G+H DG K + PE G K ++ L +G+A++ ++ +G Sbjct 290 ANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDSMGYKED 349 Query 351 EVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQ 410 E L + ++L D+ V DL ++ + R + + ++ SG + Sbjct 350 EYNLDALYADFLKLADRKGQVFDYDLEALMHFSNLREEDDFYKLNYLSVQSG-SVMATTS 408 Query 411 IELEYQGKIHKEISEGDGGYDAFMNALTKIT 441 I+++ E + G+G DA + ++T Sbjct 409 IKMQCGDAEMCEAAVGNGPVDALYQCIYRVT 439 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Cronobacter sakazakii ATCC BAA-894] Sequence ID: A7MIC5.1 Length: 523 Range 1: 7 to 505 Score:140 bits(352), Expect:9e-35, Method:Compositional matrix adjust., Identities:132/519(25%), Positives:232/519(44%), Gaps:32/519(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ S S EKL IA L+++ VD +E+ S G+ E+VQ I Sbjct 7 IFDTTLRDGEQALQASLSVKEKLQIA-LALERMGVDVMEVGFPVSSPGDFESVQTI---- 61 Query 70 ATEQLTERIEILGFV---DGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A + R+ L D + + +K + A ++ S H+ +L T E Sbjct 62 ARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIER 121 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 ++++ A + ED R + +VE I +PDT+G P Sbjct 122 AVYMVKRARNYTDDVEFSCEDAG---RTPIADLARVVEAAINAGATTINIPDTVGYTLPF 178 Query 187 ETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 E + L ++ P+I H H+D ++V N+L A++AG + + ++NG+GERAGN Sbjct 179 EFSNIISGLYERVPNIDKAVISVHTHDDLGMAVGNALAAVQAGARQVEGTLNGIGERAGN 238 Query 244 TPLEALVTTI---HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAG 300 LE ++ I + N T IN I S+ V I AN+ +VG F ++G Sbjct 239 CALEEVIMAIKLRQNLMNVHTRINHQEIWRTSQTVSQICNMPIPANKAVVGSGAFAHSSG 298 Query 301 VHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 +H DG K + PE G + L +G+A++ ++++G ++ L + + Sbjct 299 IHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYHENDYNLDDLYD 358 Query 360 RVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKI 419 ++L D+ V DL + + + ++ ++ SG A ++L +I Sbjct 359 AFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLEYFSVQSGSNAMATASVKLACGEEI 418 Query 420 HKEISEGDGGYDAFMNALTKITNRLGISIPKLIDYEVRIPPGGKTDAL--VETRITWNKS 477 E + G+G DA A+ +IT+ +L+ Y++ GK +AL V+ +++N Sbjct 419 KAEAANGNGPVDAVYQAINRITDY----DIELVKYQLGAKGHGK-NALGQVDIVVSYN-- 471 Query 478 LDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQPWQI 516 + F +G+ D ++ A +LN I + ++ Sbjct 472 -----GRHFHGVGLTTDIVESSARAMINVLNNIWRAGEV 505 >RecName: Full=Homocitrate synthase 1 [Nostoc sp. PCC 7120 = FACHB-418] Sequence ID: Q44290.2 Length: 377 Range 1: 6 to 347 Score:137 bits(344), Expect:1e-34, Method:Compositional matrix adjust., Identities:106/355(30%), Positives:168/355(47%), Gaps:16/355(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ GV F+ EK+ IAKFL + V +E+ + + E+ + Sbjct 6 INDTTLRDGEQAAGVVFTLEEKVAIAKFL-DTIGVPELEVGIPAMGEEEMRAI------C 58 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDS---GAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 A L + +L + + IK S G + +++ S + + + Sbjct 59 AISNLGLKANLLAW--NRAVISDIKASVACGMERVHIAIPVSGIQIAAKFHGQWRVSLQR 116 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 + I +A+ GL + V ED S R +++ + + + R DT+GVL P Sbjct 117 LKDCISFAVDQGLWVAVGGEDSS---RADENFLLDVALYAQEWGASRFRFCDTVGVLDPF 173 Query 187 ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 T+ V L+ I E H HND+ ++ AN+L I+AG ++ ++ GLGERAGN L Sbjct 174 TTYGKVKLLVSAL-TIPVEVHTHNDFGMATANALAGIKAGASSVNTTVIGLGERAGNAAL 232 Query 247 EALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGD 306 E +V I I+ + E S+LV SG + + IVGE+ F +G+HA G Sbjct 233 EEVVMAIKRIYGVDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFAHESGIHAHGV 292 Query 307 KKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 + P PE G +R +GK +G+ S+S ++Q G+ L+ Q VL+ V Sbjct 293 LQNPDTYEPFAPEEVGWERRLVVGKHSGRHSVSNLLEQHGIFLNPEETQSVLDAV 347 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Salinibacter ruber M8] Sequence ID: D5HB86.1 Length: 546 Range 1: 5 to 497 Score:139 bits(350), Expect:2e-34, Method:Compositional matrix adjust., Identities:131/516(25%), Positives:221/516(42%), Gaps:69/516(13%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D TLRDGEQ G S + EK++IA L LNVD +E S + E V +I Sbjct 5 ITIFDTTLRDGEQAPGASMTVPEKVHIAH-KLADLNVDVIEAGFPISSPAQTEAVTRI-- 61 Query 68 WAATEQLTERIEILGFVDGNKTVDWIK------DSGAKVLNLLTKGSLH--------HLE 113 ATE VDG T + D+ + L T LH H+E Sbjct 62 --ATE-----------VDGPVTCALARTKEDDIDAAGEALADGTDTRLHTFIATSDVHIE 108 Query 114 KQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLED----WSNGFRNSPDYVKSLVEHLSKE 169 + K +I+ A+++ + Y ++ + R P+++ +V+ ++ Sbjct 109 AKFDKLGNTMAEKREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEA 168 Query 170 HIERIFLPDTLGVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAG 226 I +PDT G +P E +++++ PD + H H+D L+ AN+L IRAG Sbjct 169 GATTINIPDTTGYCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAG 228 Query 227 VKGLHASINGLGERAGNTPLEALV---TTIHDKSNSKTNINEIAITEASRLVEVFSGKRI 283 + + +ING+GERAGN LE +V T D + +++ +T S+ V +G + Sbjct 229 ARQVECTINGIGERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPV 288 Query 284 SANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGR-KRSYALGKLAGKASISENV 342 N+ IVG + F+ AG+H G + + G+ LG+ +G+ + + Sbjct 289 QPNKAIVGSNAFSHEAGIHQHGVLEERTTYEIMSATDVGQDAEQIRLGRHSGRHGLFNRL 348 Query 343 KQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRT--------------- 387 + +G + E + +R ++L D+ K V EDL ++ D G Sbjct 349 EAMGYAVPEGHRDALYDRFLDLADRKKEVFEEDLEQMMNDFGGDAVAAATGLPDNGVALN 408 Query 388 -GEKVLTIKSCNIHSGIGIRPHAQIELEYQ---GKIHKEISEGDGGYDAFMNALTKITNR 443 G + ++H + A++ + Q G +E + G+G DA AL Sbjct 409 GGTPAYRLDQFSVH--LSSDDEAKVSVRLQRDDGSAREEQATGEGPVDALYRALDH---- 462 Query 444 LGISIP-KLIDYEVR-IPPGGKTDALVETRITWNKS 477 + P L+DY +R I G VE I + ++ Sbjct 463 -AVDAPHTLVDYSIRSISEGADAQGEVEVTIRYGEN 497 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Uroleucon rurale)] Sequence ID: Q9EVE3.1 Length: 437 Range 1: 1 to 436 Score:137 bits(344), Expect:4e-34, Method:Compositional matrix adjust., Identities:122/451(27%), Positives:213/451(47%), Gaps:28/451(6%) Query 30 EKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQLTERIEILGFVDGNKT 89 EKL IA L+K+ VD +E+ S G+ ++VQ I + ++ L K Sbjct 1 EKLQIA-LSLEKIGVDIMEVGFPISSPGDFKSVQTISKNIKNSRICSLARCL-----EKD 54 Query 90 VDWIKDSGAKVLN----LLTKGSLHHLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYL 145 +D ++ + N + S H+E +L K E F ++ A++ + Sbjct 55 IDAAGEAMSVCDNFRIHIFLATSTLHIESKLRKNFNEIIEMAIFSVKKALRYTNDVEFSC 114 Query 146 EDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIH-- 203 ED S R + D + +VE L K ++ I +PDT+G +P+E + +L ++ P+IH Sbjct 115 EDAS---RTNIDNLCRIVEKLIKSGVKTINIPDTVGYSTPDELTFIIKNLFERVPNIHKS 171 Query 204 -FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSN---S 259 H H+D ++V NS+ AI+AG + + +ING+GERAGNT LE ++ I + N Sbjct 172 IISVHCHDDLGMAVGNSIAAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVRKNILGV 231 Query 260 KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPE 319 TNIN I S+++ I +N+ IVG + F+ ++G+H DG K + P Sbjct 232 STNINHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDPR 291 Query 320 RFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPF 378 G K+ L +G+A++ + ++G S+ + ++ ++L D+ V DL Sbjct 292 SIGLKKVKLNLTSRSGRAAVKYYMSEMGYKDSDYNIDELYTDFLKLADKKGQVFDYDLES 351 Query 379 IIADVSGRTGE-KVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEIS-EGDGGYDAFMNA 436 +A ++ + E + ++ ++ S A ++L K + E S +G DA A Sbjct 352 -LAFINKQQDELEYFRLQFFSVQSISNNLSTASVKLLCGNKTYTESSTTSNGPVDAIYQA 410 Query 437 LTKITNRLGISIPKLIDYEVRIPPGGKTDAL 467 L +IT+ P ++ I G DAL Sbjct 411 LNRITH-----FPIILQKFQLIAKGKGKDAL 436 >RecName: Full=Homocitrate synthase [Frankia sp. FaC1] Sequence ID: P54610.1 Length: 401 Range 1: 16 to 379 Score:134 bits(338), Expect:1e-33, Method:Compositional matrix adjust., Identities:105/381(28%), Positives:187/381(49%), Gaps:22/381(5%) Query 2 TKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET 61 T+ + + D TLRDGEQ GV+F+ +EKL IA L + V ++E + E + Sbjct 16 TQPDAVVRFCDTTLRDGEQAPGVAFTAAEKLAIAG-ALDAIGVHQIEAGIPGMGVTERDV 74 Query 62 VQKIMEWAATEQLTERIEILGFVDGN-KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 +++I+ AT+ + EI+G+ + + V+ G +L S HL+ +L + Sbjct 75 LREIL---ATDP---KAEIVGWCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLERDR 128 Query 121 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 V + G++++V ED S R +V L L + R+ DT+ Sbjct 129 AWARRRVRDCVVDGTDRGMRVSVGFEDAS---RADDAFVTDLAGELRDVGVTRLRWADTV 185 Query 181 GVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 G+L P + + L++ P +E H H+D+ L+ AN++ A++AG + ++ GLGER Sbjct 186 GLLDPVSAYDRLGRLVRAVPG-PWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGER 244 Query 241 AGNTPLEALVTTIHDKSNSKTNINEIAITEASRLV---EVFSGKRISANRPIVGEDVFTQ 297 AGN P+E + + +++ + ++LV + +GK+ +VGE VF Sbjct 245 AGNAPIEEVAMALRHLLKLPIDLDTTSFRTLAQLVVGWPLPAGKKA-----VVGESVFAH 299 Query 298 TAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKV 357 +G+H G + P PE GR+R +GK +G+AS+ ++Q G+ E L+ + Sbjct 300 ESGIHVHGILRHPATYEPFDPEVGGRRR-LTVGKHSGRASLRHALEQCGITAEESELEPL 358 Query 358 LERVIELGDQNKL-VTPEDLP 377 +E+V ++K + DLP Sbjct 359 VEQVRLAATRHKRGLDSRDLP 379 >RecName: Full=Homocitrate synthase [Azotobacter chroococcum (strain mcd 1)] Sequence ID: P23122.1 Length: 382 Range 1: 6 to 353 Score:134 bits(336), Expect:2e-33, Method:Compositional matrix adjust., Identities:103/360(29%), Positives:171/360(47%), Gaps:12/360(3%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D TLRDGEQ+ GV+F+ EK+ I + L +L V +EI + + E E ++ I Sbjct 6 IDDTTLRDGEQSAGVAFNADEKIAIRR-ALAELGVPELEIGIPSMGEEEREVMRAIAGLG 64 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 + +L + F + + +G +++L S L +L + +V+ Sbjct 65 LSSRLLAWCRLCDF-----DLSAARSTGVTMVDLSLPISDLMLRHKLNRDRDWALGEVAR 119 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 ++ A +GL++ + ED S R D++ V +++ DT+GV+ P Sbjct 120 LVSEARMAGLEVCLGCEDAS---RADQDFIVR-VGAVAQAARPPPAFADTVGVMEPFGML 175 Query 190 QGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEAL 249 L Q+ D+ E H H+D+ L+ AN+L A+ G ++ ++NGLGERA N LE Sbjct 176 DRFRFLRQRL-DVELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAANAALEEC 234 Query 250 VTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 V + + T I+ I S LVE SG++ R + VFT AG+H DG K Sbjct 235 VLALKNLHGIDTGIDTRGIPAISALVERASGRQWPGRRAWLAP-VFTHEAGIHVDGLLKH 293 Query 310 NLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNK 369 + P+ GR S LGK +G + + ++LG+ L++ Q +L R+ + K Sbjct 294 RRNYEGLNPDELGRSHSLVLGKHSGAHMVRNSYRELGIELADWQSQALLGRIRAFSTRTK 353 >RecName: Full=Homocitrate synthase; Short=HCS [Pyrococcus horikoshii OT3] Sequence ID: O59390.1 Length: 361 Range 1: 2 to 340 Score:132 bits(333), Expect:3e-33, Method:Compositional matrix adjust., Identities:105/352(30%), Positives:172/352(48%), Gaps:13/352(3%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 ILD TLR+GEQT GV++S ++L IA L ++ VD +E+ VSK ++ I Sbjct 2 ILDSTLREGEQTPGVNYSPEQRLRIA-LALDEIGVDFIEVGHPAVSKDVFIGIKLIASQD 60 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 L L + +D++ + + + + S L K+ + + +S Sbjct 61 LNANLLAHSRAL-----LEDIDYVIQADVEWVGIFFCLSNACLRKRFRMSLSQALERISK 115 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 IEYA GLK+ ED + R + ++ +E + ++RI + DT G P + Sbjct 116 AIEYAKDHGLKVRFTPEDTT---RTEWENLRRAIELAKELKVDRISVADTTGGTHPLRFY 172 Query 190 QGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEAL 249 V ++ I H HND L++AN++ I G + A++NGLGERAG L + Sbjct 173 TLVKKVVNF--GIPVNVHCHNDLGLALANAIMGIEGGATVVDATVNGLGERAGIVDLAQI 230 Query 250 VTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 VT ++ K + + E SR+V +G + N PIVGE+ FT AG+H K Sbjct 231 VTVLYYHYGVKKYRLD-KLYEISRMVSEITGIALQPNYPIVGENAFTHKAGLHVSAVLKD 289 Query 310 NLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERV 361 + + E FGR+R+ + + AGK +I +++LG+ E V + +L+RV Sbjct 290 PRFYEFLPAEVFGRERTIYVDRFAGKDTIRYYLQKLGINDEEFV-KVLLKRV 340 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Acidimicrobium ferrooxidans DSM 10331] Sequence ID: C7M0E4.1 Length: 516 Range 1: 9 to 444 Score:134 bits(336), Expect:1e-32, Method:Compositional matrix adjust., Identities:116/447(26%), Positives:202/447(45%), Gaps:23/447(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 R+ I D TLRDGEQ G+S EKL IA+ L +L VD +E S+G+ + V++I Sbjct 9 RIRIFDTTLRDGEQAPGISLDPLEKLEIAE-QLARLGVDIIEAGFPVASQGDFDAVRQIA 67 Query 67 EWAATEQLT--ERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 + R + D + + ++D+ +++ S HLE L + + Sbjct 68 RQVHGPVICGLSRTHV---ADIERCYEAVRDAEHHRIHVFISTSPSHLEHMLRMSEDQ-- 122 Query 125 TDVSFVIEYAIKSGLKINVYLEDW----SNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 V+E ++ + ++D + R ++ +++ E + +PDT+ Sbjct 123 -----VVEAVRRAIARARELVDDVEFSPQDATRTPLPFLYRVLQVAVDEGASTLNIPDTV 177 Query 181 GVLSPEETFQGVDSLIQKYPDIH-FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGE 239 G P + + V+S+ ++ + H HND L+ ANSL A+ AG + + ING+GE Sbjct 178 GYGIPWDFARMVESVRREVAGSYVISCHCHNDLGLATANSLAAVAAGARQVECCINGIGE 237 Query 240 RAGNTPLEALVTTIHDKS----NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVF 295 RAGN LE +V + +S + T I+ + SRLV +G + N+ +VG + F Sbjct 238 RAGNAALEEVVMGLAIRSDVIGDVTTGIDTRELARTSRLVSRLTGYPVQYNKAVVGRNAF 297 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVL 354 +G+H G I G++ + LGK +G+ + E + ++G+ L L Sbjct 298 AHESGIHQHGVLTDRSTYEVIDAASVGQEAAQIVLGKHSGRHAFQEALARMGIALEGDAL 357 Query 355 QKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELE 414 +R EL D+ ++ DL I+A+ G T + S + +G G A + Sbjct 358 NATFQRFKELADRKVELSEADLEAIVAEELGTTLADRFELVSFRVEAGTGREAVASATVL 417 Query 415 YQGKIHKEISEGDGGYDAFMNALTKIT 441 G + + G+G DA L + T Sbjct 418 VDGTPVEASASGNGMVDALGRVLAEAT 444 >RecName: Full=Homocitrate synthase [Frankia alni] Sequence ID: Q47884.1 Length: 351 Range 1: 23 to 351 Score:129 bits(325), Expect:4e-32, Method:Compositional matrix adjust., Identities:92/340(27%), Positives:165/340(48%), Gaps:12/340(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 ++ D TLRDGEQ GV+F T+ + L + V ++E + E + +++I+ Sbjct 23 IKFCDTTLRDGEQAPGVAF-TAAEKLAIAAALDAIGVHQIEAGIPAMGVTERDVLREIL- 80 Query 68 WAATEQLTERIEILGFVDGN-KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 AT+ +I+G+ + + V+ G +L S HL+ +LG+ Sbjct 81 --ATDP---HADIVGWCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLGRDRAWARLR 135 Query 127 VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPE 186 V + A G++++V ED S R +V L L + + R+ DT+G+L P Sbjct 136 VRDCVADATDRGMRVSVGFEDAS---RADDAFVTDLAGELRELGVTRLRWADTVGLLDPV 192 Query 187 ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPL 246 + L++ P +E H H+D+ L+ AN++ A++AG + ++ GLGERAGN P+ Sbjct 193 SAHDRLGRLVRAVPGP-WEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPI 251 Query 247 EALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGD 306 E + + +++ + +RLV + + + A + +VGE VF +G+H G Sbjct 252 EEVAMALRHLLKLPVDLDTTSFRSLARLVSRAARRPLPAGKAVVGESVFAHESGIHVHGI 311 Query 307 KKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLG 346 + P P G +R A+GK +G+AS+ ++Q G Sbjct 312 LRHPATYEPFDPAEVGGRRRLAIGKHSGRASVRYALEQYG 351 >RecName: Full=Homocitrate synthase; Short=HCS [Pyrococcus abyssi GE5] Sequence ID: Q9V1J1.1 Length: 361 Range 1: 2 to 327 Score:129 bits(324), Expect:5e-32, Method:Compositional matrix adjust., Identities:100/343(29%), Positives:162/343(47%), Gaps:22/343(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 +LD TLR+GEQT GV+++ ++L IA L ++ VD +EI VS+ ++ I E Sbjct 2 VLDSTLREGEQTPGVNYTPEQRLEIA-IALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 +L L + +D++ +G + + S L K+ T +S Sbjct 61 LNVELLAHSRAL-----IEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISR 115 Query 130 VIEYAIKSGLKINVYLED-----WSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 IEYA GLK+ ED W+N +K + + ++RI + DT G Sbjct 116 AIEYAKDHGLKVRFTPEDTTRTEWAN--------LKRAIRLAKELKVDRISVADTTGSTH 167 Query 185 PEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 P + V ++ I H HND L++AN++ I AG + A++NGLGERAG Sbjct 168 PLRFYTLVKKIVNF--GIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIV 225 Query 245 PLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHAD 304 L ++T ++ K ++ + S LV +G N PIVGE+ FT AG+H Sbjct 226 DLAQIITVLYYHYGIKKYRLDL-LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVS 284 Query 305 GDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGM 347 K + + E FGR+R+ + + AGK +I +++ G+ Sbjct 285 AVLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327 >RecName: Full=(R)-citramalate synthase [Synechocystis sp. PCC 6803 substr. Kazusa] Sequence ID: P74269.1 Length: 547 Range 1: 1 to 500 Score:131 bits(329), Expect:2e-31, Method:Compositional matrix adjust., Identities:127/509(25%), Positives:213/509(41%), Gaps:48/509(9%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M +T L + D TLRDG Q G+S S ++KL IA+ L Q L + +E + +++ Sbjct 1 MATKKTSLWLYDTTLRDGAQREGISLSLTDKLTIARRLDQ-LGIPFIEGGWPGANPKDVQ 59 Query 61 TVQKIMEWAATEQLTERIEILGF---------VDGNKTVDWIKDSGAKVLNLLTKGSLHH 111 W E+ E+ EI+ F V+ +K + I +G + + + K H Sbjct 60 FF-----WQLQEEPLEQAEIVAFCSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLH 114 Query 112 LEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHI 171 + + L + E +S I Y G ++ E W +G+R +PDY + + + Sbjct 115 VLEGLQTSLAENLAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGA 174 Query 172 ERIFLPDTLGVLSPEETFQ---------GVDSLIQKYPDIHFEFHGHNDYDLSVANSLQA 222 E + + DT G P + + G+D + P + H HND +VANSL A Sbjct 175 EWLVMCDTNGGTLPGQISEITTKVRRSLGLDGQSDRQPQLGI--HAHNDSGTAVANSLLA 232 Query 223 IRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINE--IAITEASRLVEVFSG 280 + AG + +ING GER GN L L+ + K + E +T SRL+ Sbjct 233 VEAGATMVQGTINGYGERCGNANLCTLIPNLQLKLDYDCIEPEKLAHLTSTSRLISEIVN 292 Query 281 KRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISE 340 + P VG F G+H ++ I P G +R + + AG +++ Sbjct 293 LAPDDHAPFVGRSAFAHKGGIHVSAVQRNPFTYEHIAPNLVGNERRIVVSEQAGLSNVLS 352 Query 341 NVKQLGMVLSE--VVLQKVLERVIELGDQNKLVTPEDLPF-IIADVSGRTGEKVLTIKSC 397 + G+ L + +L + +L Q + F ++ + + + ++ Sbjct 353 KAELFGIALDRQNPACRTILATLKDLEQQGYQFEAAEASFELLMRQAMGDRQPLFLVQGF 412 Query 398 NIHSGIGIRPH---------AQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISI 448 +H + + P A +++ G+ E++EG+G A AL K R I Sbjct 413 QVHCDL-LTPAENPAYRNALATVKVTVNGQNILEVAEGNGPVSALDQALRKALTRFYPQI 471 Query 449 P--KLIDYEVRIPPGG-----KTDALVET 470 L DY+VRI GG KT LVE+ Sbjct 472 ADFHLTDYKVRILDGGAGTSAKTRVLVES 500 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Pemphigus spyrothecae)] Sequence ID: P58898.1 Length: 515 Range 1: 4 to 442 Score:130 bits(328), Expect:2e-31, Method:Compositional matrix adjust., Identities:129/451(29%), Positives:205/451(45%), Gaps:27/451(5%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGEL---ETVQ 63 ++ I D TLRDGEQ S +T +KL IA L+++ +D +E S G+ ET+ Sbjct 4 KIIIFDTTLRDGEQALQASLTTKKKLKIA-LSLEEMGIDIIEAGFPISSPGDFKSVETIS 62 Query 64 KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 K + + L +E D + + ++ + +++ S H++ +L K E Sbjct 63 KEFKSSIICSLARCVE----KDIDIAAEAMRFAKHFRIHIFLGTSPLHVKSKLKKNFSEI 118 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVL 183 F I+ A + I ED N Y+ VE++ K I +PDT+G Sbjct 119 IDMAIFAIKKAKRYTBDIEFSCEDAGRTPINQLCYI---VENVIKAGATTINIPDTVGFT 175 Query 184 SPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 P E Q + SL K P+I H HN ++ ANS+ AI+AG + + ++NG+GER Sbjct 176 IPYEFNQIIKSLYNKVPNIDKVILSVHCHNGLGMATANSITAIQAGARQIEXTMNGMGER 235 Query 241 AGNTPLEALVTTIHDKSNS---KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 AGNT LE ++ I K N+ TNI I + +L+ I +N+ I+G + F+ Sbjct 236 AGNTALEEVIIAIKLKKNNLNLHTNIKHKKIYKTRKLISEICNTVIPSNKAIIGTNAFSH 295 Query 298 TAGVHADGDKKGNLYANPILPERFGRKR-SYALGKLAGKASISENVKQLGMVLSEVVLQK 356 ++G+H DG K I P+ G K L +G+A++ ++ ++G L Sbjct 296 SSGIHQDGILKNRKNYEIITPKSIGLKPIKLNLTSRSGRAAVKYHMTEMGYDEKLYKLDI 355 Query 357 VLERVIELGDQNKLVTP---EDLPFIIADVSGRTGEKVLTIKSCNI-HSGIGIRPHAQIE 412 + ++L D+ V E L FI D T E +K N+ H GI + IE Sbjct 356 LYNSFLKLADRKGQVFDYELESLAFI--DQKENTTEH-FRLKKFNVQHQSTGITI-SSIE 411 Query 413 LEYQGKIHKEISEGDGGY-DAFMNALTKITN 442 L KI + G ++ L KITN Sbjct 412 LYCGKKIKTANTRTKKGLVNSIYITLNKITN 442 >RecName: Full=(R)-citramalate synthase [Thermotoga maritima MSB8] Sequence ID: Q9WZ22.1 Length: 538 Range 1: 3 to 476 Score:125 bits(315), Expect:8e-30, Method:Compositional matrix adjust., Identities:127/484(26%), Positives:225/484(46%), Gaps:43/484(8%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVE----------IASARVSKG 57 +++ D TLRDG Q GVSFS +K+ IA+ L L V +E IA KG Sbjct 3 IKVYDTTLRDGAQAFGVSFSLEDKIRIAE-ALDDLGVHYLEGGWPGSNPKDIAFFEAVKG 61 Query 58 ELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLG 117 K+ +++T + +IE D N + + + V + K H+EK L Sbjct 62 MNFKNLKVAAFSSTRRPDVKIE----EDAN--IQTLIKAETPVYTIFGKSWDLHVEKALR 115 Query 118 KTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 T +E + + Y + ++ E + +G++ + +Y ++ + + + L Sbjct 116 TTLEENLKMIYDTVSYLKRFADEVIYDAEHFFDGYKANREYALKTLKVAEEAGADCLVLA 175 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 DT G P E + ++ ++K+ H HND D++VAN+L A+R G + +INGL Sbjct 176 DTNGGTLPHEIEEIIED-VKKHVKAPLGIHAHNDSDVAVANTLAAVRKGAVHVQGTINGL 234 Query 238 GERAGNTPLEALVTTIHDKSN----SKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 GER GN L +++ + K K N+ + + + + LV SG+ N P VG+ Sbjct 235 GERCGNANLCSVIPNLVLKMGLEVIPKENLKK--LFDVAHLVAELSGRPHIENMPYVGDY 292 Query 294 VFTQTAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVV 353 F GVH K+ I PE G +R ++ +L+GK+++ E +K++G + E Sbjct 293 AFAHKGGVHVSAIKRDPRTYEHIDPELVGNRRIISISELSGKSNVLEKIKEMGFEIDESS 352 Query 354 --LQKVLERVIELGDQNKLVTPEDLPF--IIADVSGRT-------GEKVLTIKSCNIHS- 401 ++++L+++ EL Q + F ++ D+ G+ G V+TIK+ + S Sbjct 353 PKVREILKKIKELEAQGYHFEGAEASFELLVRDMLGKRKKYFEFLGFTVMTIKNRDEESF 412 Query 402 ---GIGIRPHAQI--ELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP--KLIDY 454 + +R ++ L + +EG+G +A A+ K + S+ KL DY Sbjct 413 SEATVKVRVPDEVAKRLGHDEPFEHTAAEGEGPVEALDRAVRKALEKFYPSLKDTKLTDY 472 Query 455 EVRI 458 +VRI Sbjct 473 KVRI 476 >RecName: Full=Homocitrate synthase; Short=HCS [Thermus thermophilus HB27] Sequence ID: O87198.2 Length: 376 Range 1: 5 to 365 Score:122 bits(306), Expect:2e-29, Method:Compositional matrix adjust., Identities:97/370(26%), Positives:173/370(46%), Gaps:13/370(3%) Query 9 EILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEW 68 +I+D TLR+GEQ +FST +K+ IAK L + ++ +E+ + S + + + Sbjct 5 KIIDSTLREGEQFEKANFSTQDKVEIAK-ALDEFGIEYIEVTTPVASPQSRKDAEVLASL 63 Query 69 AATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVS 128 ++ I+ +D K ++G + ++LL G+ +L G+ + Sbjct 64 GLKAKVVTHIQCR--LDAAKVA---VETGVQGIDLLF-GTSKYLRAAHGRDIPRIIEEAK 117 Query 129 FVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEET 188 VI Y ++ + V + FR+ + ++ E ++ +++R+ L DT+GV +P + Sbjct 118 EVIAYIREAAPHVEVRF-SAEDTFRSEEQDLLAVYEAVAP-YVDRVGLADTVGVATPRQV 175 Query 189 FQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 + V + + P + EFHGHND ++AN+ +AI AG + +I G+GER G TPL Sbjct 176 YALVREVRRVVGPRVDIEFHGHNDTGCAIANAYEAIEAGATHVDTTILGIGERNGITPLG 235 Query 248 ALVTTIH--DKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADG 305 + ++ + + E R+V G I N I GE F+ AG+H Sbjct 236 GFLARMYTLQPEYVRRKYKLEMLPELDRMVARMVGVEIPFNNYITGETAFSHKAGMHLKA 295 Query 306 DKKGNLYANPILPERFGRKRSYALG-KLAGKASISENVKQLGMVLSEVVLQKVLERVIEL 364 P PE FG KR + +L G+ +I ++LG+ E L +V + + L Sbjct 296 IYINPEAYEPYPPEVFGVKRKLIIASRLTGRHAIKARAEELGLHYGEEELHRVTQHIKAL 355 Query 365 GDQNKLVTPE 374 D+ +L E Sbjct 356 ADRGQLTLEE 365 >RecName: Full=(R)-citramalate synthase [Aquifex aeolicus VF5] Sequence ID: O66682.1 Length: 528 Range 1: 4 to 470 Score:123 bits(309), Expect:6e-29, Method:Compositional matrix adjust., Identities:118/480(25%), Positives:210/480(43%), Gaps:41/480(8%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVE-----------IASARVS 55 ++ I D TLRDG Q GVSFS +K+ IA+ L + +E + + Sbjct 4 KVYIYDTTLRDGSQMEGVSFSLEDKIRIAE-KLDDFGIHYIEGGWPYANPKDNLFFQKAK 62 Query 56 KGELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 K + K+ + +T + ++ V + V+ + + V+ + K H+ Sbjct 63 KMNFKNA-KLTAFGSTRRPNKK------VSEDPQVESLIKAETPVVTIFGKSWDLHVTDA 115 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 L T +E + +EY + ++ E + +G++++P+Y ++E K + + Sbjct 116 LKTTLEENLNMIYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVV 175 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASIN 235 L DT G P E ++ + +++ D + H HND + +VANSL A+ AG + +H +IN Sbjct 176 LCDTNGGTLPHEIYEITKKVKERFKDANVGIHAHNDSETAVANSLMAVLAGARQVHGTIN 235 Query 236 GLGERAGNTPLEALVTTIHDKSN----SKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 G+GER GN L +++ + K + N+ + +TE + V + N P VG Sbjct 236 GIGERTGNANLCSIIPNLQLKLGFDVIPQENLKK--LTELANFVAEIINMPLPRNMPYVG 293 Query 292 EDVFTQTAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSE 351 E F GVHA K I PE G KR + LAG++++ +K+ G+ + Sbjct 294 ESAFAHKGGVHASAVLKNAKTYEHINPELVGNKRKITVSDLAGRSNLVHKLKEFGIEIDP 353 Query 352 VV--LQKVLERVIELGDQNKLVTPEDLPF---------IIADVSGRTGEKVLTIKSCNIH 400 L+K+++++ EL + + ++ D +VL K + Sbjct 354 KSPELKKLIDKIKELEKEGYHFEAAEASLELLIKRHFGLVKDYFDFDAYRVLIAKRRDDS 413 Query 401 SGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP--KLIDYEVRI 458 A + L +G S G+G A AL K ++ +LIDY+VRI Sbjct 414 LPTS---EATVRLSVEGVEEHTASLGNGPISALDRALRKALEEFYPNLKELQLIDYKVRI 470 >RecName: Full=(R)-citramalate synthase [Streptomyces coelicolor A3(2)] Sequence ID: O86511.1 Length: 534 Range 1: 5 to 479 Score:123 bits(309), Expect:6e-29, Method:Compositional matrix adjust., Identities:130/489(27%), Positives:217/489(44%), Gaps:43/489(8%) Query 2 TKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET 61 ++++ + D TLRDG Q G++ + ++KL IA+ L V +E + + E Sbjct 5 SELDDSFHVFDTTLRDGAQREGINLTVADKLAIARHL-DDFGVGFIEGGWPGANPRDTEF 63 Query 62 VQKIMEWAATEQLTERIEILGFVDGNKT---------VDWIKDSGAKVLNLLTKGSLHHL 112 + A E + +++ F + V + DSGA+V+ L+ K H+ Sbjct 64 FAR----ARQEIDFKHAQLVAFGSTRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHV 119 Query 113 EKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIE 172 E L T E V+ + + G ++ V E + +G+R +P+Y KS+V S+ + Sbjct 120 ELALRTTLDENLAMVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGAD 179 Query 173 RIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 + L DT G + P + Q V + + H +D +VAN+L A+ AG + Sbjct 180 VVVLCDTNGGMLPAQ-IQAVVATVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQC 238 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFS---GKRISANRPI 289 + NG GER GN L +V + K K + E + E +R+ + S ++P Sbjct 239 TANGYGERVGNANLFPVVAALELKYG-KQVLPEGRLREMTRISHAIAEVVNLTPSTHQPY 297 Query 290 VGEDVFTQTAGVHADGDK-KGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMV 348 VG F AG+HA K +LY + I PE G + +AG+ASI K+LG+ Sbjct 298 VGVSAFAHKAGLHASAIKVDPDLYQH-IDPELVGNTMRMLVSDMAGRASIELKGKELGID 356 Query 349 LS--EVVLQKVLERVIELGDQNKLVTPEDLPF---IIADVSGRTGEKVLTIKSCNIHSGI 403 L ++ +V+ERV E D F + A+ GR +K + S Sbjct 357 LGGDRELVGRVVERVKERELAGYTYEAADASFELLLRAEAEGR------PLKYFEVESWR 410 Query 404 GI---RP------HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPK--LI 452 I RP A ++L +G+ +EG+G +A +L ++ + K L+ Sbjct 411 AITEDRPDGSHANEATVKLWAKGERIVATAEGNGPVNALDRSLRVALEKIYPELAKLDLV 470 Query 453 DYEVRIPPG 461 DY+VRI G Sbjct 471 DYKVRILEG 479 >RecName: Full=Homocitrate synthase [Klebsiella pneumoniae] Sequence ID: P05345.2 Length: 381 Range 1: 3 to 365 Score:117 bits(293), Expect:1e-27, Method:Compositional matrix adjust., Identities:98/383(26%), Positives:170/383(44%), Gaps:30/383(7%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ--- 63 R+ I D TLRDGEQ+ GV+F TSEK+ IA+ L + +E+ + + E+ +Q Sbjct 3 RVLINDTTLRDGEQSPGVAFRTSEKVAIAEALYAA-GITAMEVGTPAMGDEEIARIQLVR 61 Query 64 ------KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLG 117 +M W L R + +DW+ ++ S + +L Sbjct 62 RQLPDATLMTWCRMNALEIR------QSADLGIDWV--------DISIPASDKLRQYKLR 107 Query 118 KTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + ++ I A GLK+ + ED S R S ++++ E R+ Sbjct 108 EPLAVLLERLAMFIHLAHTLGLKVCIGCEDAS---RASGQTLRAIAEVAQNAPAARLRYA 164 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 DT+G+L P T + +L + E H HND ++ AN+L A+ AG ++ ++ GL Sbjct 165 DTVGLLDPFTTAAQISALRDVWSG-EIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGL 223 Query 238 GERAGN-TPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFT 296 GERAGN + + +T ++ A+ + V + + I +P+VGE VFT Sbjct 224 GERAGNAAAWKPSALGLERCLGVETGVHFSALPALCQRVAEAAQRAIDPQQPLVGELVFT 283 Query 297 QTAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQK 356 +GVH + + I P GR LGK +G+ +++ Q+G L+ + + Sbjct 284 HESGVHVAALLRDSESYQSIAPSLMGRSYRLVLGKHSGRQAVNGVFDQMGYHLNAAQINQ 343 Query 357 VLERVIELGDQNKLVTPEDLPFI 379 +L + + K +P+D + Sbjct 344 LLPAIRRFAENWKR-SPKDYELV 365 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Buchnera aphidicola (Thelaxes suberi)] Sequence ID: O31287.1 Length: 375 Range 1: 2 to 358 Score:114 bits(284), Expect:2e-26, Method:Compositional matrix adjust., Identities:102/370(28%), Positives:176/370(47%), Gaps:25/370(6%) Query 153 RNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGH 209 R S D + +VE K I +PDT+G P + + +L K P+I+ H H Sbjct 2 RTSIDNLCRIVESAIKAGATTINIPDTVGYTIPSQFKTIIKNLFNKVPNINNAIISAHCH 61 Query 210 NDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKS---NSKTNINEI 266 +D L+V N++ +I AGV+ + +I+G+GERAGNT LE ++ TI K N TNI Sbjct 62 DDLGLAVGNAIASIEAGVRQIEGTISGIGERAGNTALEEVILTIKLKEELLNVFTNIKHN 121 Query 267 AITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRKR- 325 + S+L+ I AN+ I+G + F ++G+H DG K I P+ G K Sbjct 122 ELYRTSQLISQLCNTPIPANKSIIGSNAFAHSSGIHQDGILKNRANYEIIDPKTIGVKAV 181 Query 326 SYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSG 385 L +G+A++ ++ ++G + L ++ ++L D+ V DL +A +S Sbjct 182 QLNLTSRSGRAAVKHHMHEMGYQDDDYDLNQLYVNFLKLADKKGQVFDYDLE-ALAFISN 240 Query 386 R--TGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKE-ISEGDGGYDAFMNALTKITN 442 + ++ +K +IHSG A ++L KI E I+ +G ++ AL I Sbjct 241 QEDKDQEHFQLKYFSIHSGSTGVSTASVKLLCGNKILNEIITTRNGPINSIYQALNNIA- 299 Query 443 RLGISIPKLIDYEVRIPPGGKTDAL--VETRITWNKSLDLEEDQTFKTMGVHPDQTVAAV 500 +P +++ + G DAL V+ + +N ++ F +G+ D +++ Sbjct 300 ----GLPIVLEKFHLVGKGEGRDALGQVDIVVKYN-------NRKFHGIGLATDIIESSI 348 Query 501 HATEKMLNQI 510 A +LN I Sbjct 349 KAMLNVLNNI 358 >RecName: Full=(R)-citramalate synthase; AltName: Full=Citramalate synthase; Short=CMS [Sulfolobus acidocaldarius DSM 639] Sequence ID: Q4J6H1.1 Length: 523 Range 1: 6 to 350 Score:114 bits(285), Expect:7e-26, Method:Compositional matrix adjust., Identities:95/350(27%), Positives:166/350(47%), Gaps:15/350(4%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 +E+LD TLRDG QT +SF+ ++K+ IA LL +L VD +E + + E ++I + Sbjct 6 VEVLDTTLRDGAQTANISFTLNDKIRIA-LLLDELGVDYIEGGWPSSNPKDEEFFKEIKK 64 Query 68 WAATEQLTERIEILG-------FVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 + T+ RI G +++++ I + V L K H+ L + Sbjct 65 YKLTKA---RIAAFGSTRKKESTAKEDQSLNSIIKADVDVGVLFGKSWSLHVTDVLKISL 121 Query 121 KEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTL 180 +E + + Y GL++ E + G++ + +Y V+ + + I L DT Sbjct 122 EENLDIIYDSVNYLKSHGLRVVYDAEHFYQGYKENREYALKAVKTAEEAGADVIVLCDTN 181 Query 181 GVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGER 240 G P E + ++ + + H HND +VAN++ + AG + + +ING+GER Sbjct 182 GGTLPHEVYNITKDVVN-HVKVKIGLHMHNDSGGAVANTVMGVVAGARHVQGTINGIGER 240 Query 241 AGNTPLEALVTTIHDK---SNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQ 297 GN L ++ I K ++ K N + + E SR+V G + +P VG+ FT Sbjct 241 TGNADLIQVIPNIMLKLGLNSLKGNESLKKLKEVSRVVYEIIGVHPNPYQPYVGDFAFTH 300 Query 298 TAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGM 347 AGVHAD K I P G R + + ++AG +++ +++LG+ Sbjct 301 KAGVHADAVMKVTRAYEHIDPTLVGNNRRFVISEVAGSSNVIYYLEKLGI 350 >RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS; Flags: Precursor [Saccharomyces cerevisiae S288C] Sequence ID: Q12122.1 Length: 440 Range 1: 37 to 403 Score:108 bits(269), Expect:4e-24, Method:Compositional matrix adjust., Identities:104/387(27%), Positives:176/387(45%), Gaps:32/387(8%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 +++D TLR+GEQ F T +K+ IA+ L VD +E+ S S+ + + I + Sbjct 37 FQLIDSTLREGEQFANAFFDTEKKIEIAR-ALDDFGVDYIELTSPVASEQSRKDCEAICK 95 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 ++ I D V+ +G ++++ S + GK Sbjct 96 LGLKAKILTHIR-CHMDDARVAVE----TGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSA 150 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 VIE+ G++I ED FR+ + ++ + + K + R+ + DT+G +P + Sbjct 151 VEVIEFVKSKGIEIRFSSED---SFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQ 207 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 ++ + +L + E H HND ++AN+ A+ G + + S+ G+GER G TPL Sbjct 208 VYELIRTL-KSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG 266 Query 248 AL----VTTIHDKSNSKTNINEIAITE--ASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 L + D SK +++I E + VEV I N PI G FT AG+ Sbjct 267 GLMARMIVAAPDYVRSKYKLHKIRDIENLVADAVEV----NIPFNNPITGFCAFTHKAGI 322 Query 302 HADGDKKGNLYANP-----ILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQ 355 HA + ANP + P FG KR + +L G +I V QL + L++ ++ Sbjct 323 HAKA-----ILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIK 377 Query 356 KVLERVIELGDQNKLVTPEDLPFIIAD 382 +V ++ +LGD L +D+ II D Sbjct 378 EVTAKIKKLGDVRPL-NIDDVDSIIKD 403 >RecName: Full=Homocitrate synthase, cytosolic isozyme; Short=HCS [Saccharomyces cerevisiae S288C] Sequence ID: P48570.1 Length: 428 Range 1: 23 to 378 Score:107 bits(268), Expect:4e-24, Method:Compositional matrix adjust., Identities:100/375(27%), Positives:171/375(45%), Gaps:31/375(8%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 +++D TLR+GEQ F T +K+ IA+ L VD +E+ S S+ + + I + Sbjct 23 FQLIDSTLREGEQFANAFFDTEKKIEIAR-ALDDFGVDYIELTSPVASEQSRKDCEAICK 81 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 ++ I +D K ++G ++++ S + GK Sbjct 82 LGLKAKILTHIRC--HMDDAKVA---VETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSA 136 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 VIE+ G++I ED FR+ + ++ + + K + R+ + DT+G +P + Sbjct 137 VEVIEFVKSKGIEIRFSSED---SFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQ 193 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 ++ + +L + E H HND ++AN+ A+ G + + S+ G+GER G TPL Sbjct 194 VYELIRTL-KSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG 252 Query 248 AL----VTTIHDKSNSKTNINEIAITE--ASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 L + D SK +++I E + VEV I N PI G FT AG+ Sbjct 253 GLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEV----NIPFNNPITGFCAFTHKAGI 308 Query 302 HADGDKKGNLYANP-----ILPERFGRKRS-YALGKLAGKASISENVKQLGMVLSEVVLQ 355 HA + ANP + P FG KR + +L G +I V QL + L++ ++ Sbjct 309 HAKA-----ILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIK 363 Query 356 KVLERVIELGDQNKL 370 +V ++ +LGD L Sbjct 364 EVTAKIKKLGDVRSL 378 >RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS; Flags: Precursor [Schizosaccharomyces pombe 972h-] Sequence ID: Q9Y823.1 Length: 418 Range 1: 35 to 390 Score:107 bits(267), Expect:6e-24, Method:Compositional matrix adjust., Identities:100/373(27%), Positives:170/373(45%), Gaps:27/373(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 I++ TLR+GEQ F T +K+ IAK L VD +E+ S S+ + + I + Sbjct 35 FSIIESTLREGEQFANAFFDTEKKIQIAK-ALDNFGVDYIELTSPVASEQSRQDCEAICK 93 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 ++ I D V+ +G ++++ S + + GK Sbjct 94 LGLKCKILTHIR-CHMDDARVAVE----TGVDGVDVVIGTSQYLRKYSHGKDMTYIIDSA 148 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 + VI + G+++ ED FR+ + SL + + K + R+ + DT+G +P + Sbjct 149 TEVINFVKSKGIEVRFSSED---SFRSDLVDLLSLYKAVDKIGVNRVGIADTVGCATPRQ 205 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 + + +L + E H HND +++AN+ A+ AG + SI G+GER G TPL Sbjct 206 VYDLIRTL-RGVVSCDIECHFHNDTGMAIANAYCALEAGATHIDTSILGIGERNGITPLG 264 Query 248 ALVTTIH--DKS--NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 AL+ ++ D+ K +N+ + E LV +I N I G FT AG+HA Sbjct 265 ALLARMYVTDREYITHKYKLNQ--LRELENLVADAVEVQIPFNNYITGMCAFTHKAGIHA 322 Query 304 DGDKKGNLYANP-----ILPERFGRKRSYALG-KLAGKASISENVKQLGMVLSEVVLQKV 357 + ANP + PE FG R +G +L G +I +QL + L++ +++ Sbjct 323 KA-----ILANPSTYEILKPEDFGMSRYVHVGSRLTGWNAIKSRAEQLNLHLTDAQAKEL 377 Query 358 LERVIELGDQNKL 370 R+ +L D L Sbjct 378 TVRIKKLADVRTL 390 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thermus thermophilus] Sequence ID: Q56216.1 Length: 331 Range 1: 9 to 296 Score:104 bits(260), Expect:1e-23, Method:Compositional matrix adjust., Identities:89/299(30%), Positives:144/299(48%), Gaps:16/299(5%) Query 201 DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIH---DKS 257 D+ H H+D ++ AN+L + G + +ING+GERAGN LE +V ++ D Sbjct 9 DVVISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMALYVRRDWY 68 Query 258 NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPIL 317 + T IN I SRLVE ++G + N+ IVG++ F +G+H DG K + Sbjct 69 KAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKHRATYEIMD 128 Query 318 PERFGRKRS-YALGKLAGKASISENVKQLGMV-LSEVVLQKVLERVIELGDQNKLVTPED 375 E GR+ + LGK +G+A+ + ++ LG LSE ++K+ R E+ ++ ++ E+ Sbjct 129 AELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFKEIAEKKGPLSAEE 188 Query 376 LPFIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMN 435 L ++ T ++ SG G+ P A ++++ GDG DA Sbjct 189 LQALVESEREPTSH-FFQLEHVQFFSGSGLLPTATVKVKTPDGERLATHTGDGPVDAVYK 247 Query 436 ALTKITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPD 494 A I +G+ P+L Y V G T+AL + + L L E Q +GV PD Sbjct 248 A---IQEAIGLR-PELELYRVEAIT-GSTEALGQVTV----RLRLGELQAVG-VGVSPD 296 >RecName: Full=Homocitrate synthase [Azospirillum brasilense] Sequence ID: P70728.1 Length: 376 Range 1: 7 to 341 Score:105 bits(261), Expect:2e-23, Method:Compositional matrix adjust., Identities:92/350(26%), Positives:156/350(44%), Gaps:15/350(4%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 I D RDGEQT GV+F+ EK+ IA+ L + V +EI + + E E ++ + Sbjct 7 INDTHARDGEQTAGVAFTLDEKIAIAQ-ALDEAGVAELEIGIPAMGREERERIRAV---- 61 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF 129 A+ L R+ + + D S A +L S H+ K+L + ++ Sbjct 62 ASLGLKARLMVWCRM---HDTDLKARSTAVAPSLSVPVSDIHITKKLNGSRAWALREIER 118 Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETF 189 ++ A GL++++ ED S R D+ L+ + R DTLGVL P + Sbjct 119 KVKTARDHGLEVSLGGEDSS---RADMDF---LIAAATVAQRPRFRFADTLGVLDPFQHA 172 Query 190 QGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEAL 249 + + P+I + H + + +L A+ G ++ ++NGLGERAGN PLE + Sbjct 173 RLHLTAAATDPEIGYHAHTPRLANATAWVTLAAVLGGATHVNTTVNGLGERAGNAPLEEV 232 Query 250 VTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 V ++ ++ A+ S LVE S + ++ N+ IV + VFT AG+H DG Sbjct 233 VVSLKVLYGQDCGVDTRALGAISDLVERASNRPVAVNKSIVRDAVFTHEAGIHVDGLLTD 292 Query 310 NLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLSEVVLQKVLE 359 P R+G + + + + ++QLG+ + Q Sbjct 293 RAPTRISTPPRWGASTASCWASIPARGG-EDGLRQLGIACDDATAQACCR 341 >RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS; Flags: Precursor [Penicillium rubens Wisconsin 54-1255] Sequence ID: O94225.1 Length: 474 Range 1: 65 to 418 Score:101 bits(251), Expect:1e-21, Method:Compositional matrix adjust., Identities:97/370(26%), Positives:164/370(44%), Gaps:25/370(6%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 +R +I++ TLR+GEQ F T++K+ IAK L VD +E+ S S+ Q Sbjct 65 SRFQIIESTLREGEQFANAFFDTAKKIEIAK-ALDDFGVDYIELTSPCASE------QSR 117 Query 66 MEWAATEQLTERIEILGFVDGNKTVDWIK-DSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 + A +L + +IL + + I ++G ++++ S + E GK Sbjct 118 ADCEAICKLGLKAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSYLREHSHGKDMTYIK 177 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 VIE+ G++I ED FR+ + S+ + K + R+ + DT+G S Sbjct 178 NAAIEVIEFVKSKGIEIRFSSED---SFRSDLVDLLSIYSAVDKVGVNRVGIADTVGCAS 234 Query 185 PEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNT 244 P + ++ V +++ E H HND ++AN+ A+ AG + S+ G+GER G T Sbjct 235 PRQVYELV-RVLRGVVGCDIETHFHNDTGCAIANAFCALEAGATHIDTSVLGIGERNGIT 293 Query 245 PLEALVT--TIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVH 302 PL L+ + D+ K+ + E LV I N I G FT AG+H Sbjct 294 PLGGLMARMMVADREYVKSKYKLEKLKEIEDLVAEAVEVNIPFNNYITGFCAFTHKAGIH 353 Query 303 ADGDKKGNLYANP-----ILPERFGRKRSYALG-KLAGKASISENVKQLGMVLSEVVLQK 356 A + NP I P FG R +L G +I +QL + +++ ++ Sbjct 354 AKA-----ILNNPSTYEIINPADFGMSRYVHFASRLTGWNAIKSRAQQLKLEMTDTQYKE 408 Query 357 VLERVIELGD 366 ++ + D Sbjct 409 CTAKIKAMAD 418 >RecName: Full=Homocitrate synthase, mitochondrial; Short=HCS; Flags: Precursor [Yarrowia lipolytica CLIB122] Sequence ID: Q12726.1 Length: 446 Range 1: 46 to 403 Score:99.4 bits(246), Expect:5e-21, Method:Compositional matrix adjust., Identities:98/375(26%), Positives:162/375(43%), Gaps:27/375(7%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 ++ ++++ TLR+GEQ F T K+ IAK L VD +E+ S S+ + I Sbjct 46 SKFQLIESTLREGEQFASAFFDTETKIEIAK-ALDDFGVDYIELTSPAASEQSRSDCEAI 104 Query 66 MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 + ++ I D V +G ++++ S + GK Sbjct 105 CKLGLKAKILTHIR-CHMDDARLAVS----TGVDGVDVVIGTSQFLRQYSHGKDMNYIAQ 159 Query 126 DVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSP 185 VIE+ G++I ED FR+ + ++ + K + R+ + DT+G +P Sbjct 160 SAVEVIEFVKSHGIEIRFSSED---SFRSDLVDLLNIYRTVDKIGVNRVGIADTVGCANP 216 Query 186 EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTP 245 + ++ V +L + E H HND ++AN+ A+ AG + S+ G+GER G T Sbjct 217 RQVYELVRTL-KSVVSCDIECHFHNDTGCAIANAYTALEAGANLIDVSVLGIGERNGITS 275 Query 246 LEALVTTI----HDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGV 301 L L+ + D SK ++++ E LV I N PI G FT AG+ Sbjct 276 LGGLMARMIAADRDYVLSKYKLHKLRDLE--NLVADAVQVNIPFNNPITGFCAFTHKAGI 333 Query 302 HADGDKKGNLYANP-----ILPERFGRKRSYALG-KLAGKASISENVKQLGMVLSEVVLQ 355 HA + ANP + P FG R +L G +I V QL + L++ + Sbjct 334 HAKA-----ILANPSTYEILNPADFGLTRYIHFANRLTGWNAIKSRVDQLNLHLTDAQCK 388 Query 356 KVLERVIELGDQNKL 370 V ++ +LGD L Sbjct 389 DVTAKIKKLGDVRSL 403 >RecName: Full=Homocitrate synthase subunit alpha [Clostridium pasteurianum] Sequence ID: Q00853.1 Length: 269 Range 1: 3 to 245 Score:95.9 bits(237), Expect:5e-21, Method:Compositional matrix adjust., Identities:72/253(28%), Positives:129/253(50%), Gaps:10/253(3%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I+D TLRDGEQ G++ S +K+ IAK ++ ++ V ++E + E +V KI Sbjct 3 INIVDTTLRDGEQKAGIALSVQDKVEIAK-IISEMGVHQIEAGIPAMGGDEKISVSKI-- 59 Query 68 WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 A L +I + K +D + G ++++ + S ++ +L K K ++ Sbjct 60 --AALGLPSKIAAWNRM-STKDIDTSIECGVDIVHISSPVSDLQIKTKLEKDRKWVAENL 116 Query 128 SFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 + YA++ ++ V LED S R +++ L E + ++R+ DT+G++ P+E Sbjct 117 KRTVIYALEKDCEVTVGLEDSS---RADLNFLIQLCEMIFALGVKRVRYADTVGIMEPKE 173 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 + + + K P I E H HND+ ++++NS A +AG K +I G+GERAGN Sbjct 174 LYSQIKKIRDKVP-IDIEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGERAGNCDFL 232 Query 248 ALVTTIHDKSNSK 260 V I + + K Sbjct 233 KFVKVIQELTGEK 245 >RecName: Full=(R)-citramalate synthase; AltName: Full=Citramalate synthase [Geobacter sulfurreducens PCA] Sequence ID: Q74C76.1 Length: 528 Range 1: 4 to 476 Score:99.4 bits(246), Expect:7e-21, Method:Compositional matrix adjust., Identities:108/481(22%), Positives:208/481(43%), Gaps:30/481(6%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVE----------IASARVSKG 57 +++ D TLRDG Q +SF +K+ IA L ++ + +E +A + K Sbjct 4 VKLYDTTLRDGTQAEDISFLVEDKIRIAH-KLDEIGIHYIEGGWPGSNPKDVAFFKDIKK 62 Query 58 ELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLG 117 E + KI + +T R ++ D + + + + V + K H+ + L Sbjct 63 EKLSQAKIAAFGSTR----RAKVTP--DKDHNLKTLIQAEPDVCTIFGKTWDFHVHEALR 116 Query 118 KTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + +E + +EY + ++ E + +G++ +PDY ++ + I L Sbjct 117 ISLEENLELIFDSLEYLKANVPEVFYDAEHFFDGYKANPDYAIKTLKAAQDAKADCIVLC 176 Query 178 DTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGL 237 DT G P E + + ++K+ H HND + +VANSL A+ G+ + +ING Sbjct 177 DTNGGTMPFELVEIIRE-VRKHITAPLGIHTHNDSECAVANSLHAVSEGIVQVQGTINGF 235 Query 238 GERAGNTPLEALVTTIHDKSNSKTNINE--IAITEASRLVEVFSGKRISANRPIVGEDVF 295 GER GN L +++ + K + ++ + + SR V + + ++ VG F Sbjct 236 GERCGNANLCSIIPALKLKMKRECIGDDQLRKLRDLSRFVYELANLSPNKHQAYVGNSAF 295 Query 296 TQTAGVHADGDKKGNLYANPILPERFGRKRSYALGKLAGKASISENVKQLGMVLS--EVV 353 GVH ++ + PE G + L+G+++I ++ + + + V Sbjct 296 AHKGGVHVSAIQRHPETYEHLRPELVGNMTRVLVSDLSGRSNILAKAEEFNIKMDSKDPV 355 Query 354 LQKVLERVIELGDQNKLVTPEDLPF-IIADVSGRTGEKVLTIKSCNI-----HSGIGIRP 407 ++LE + E+ ++ + F ++ + T K ++ + H Sbjct 356 TLEILENIKEMENRGYQFEGAEASFELLMKRALGTHRKFFSVIGFRVIDEKRHEDQKPLS 415 Query 408 HAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIP--KLIDYEVRIPPGGKTD 465 A I ++ GKI +EG+G +A NAL K + + KL+DY+VR+ P G+ Sbjct 416 EATIMVKVGGKIEHTAAEGNGPVNALDNALRKALEKFYPRLKEVKLLDYKVRVLPAGQGT 475 Query 466 A 466 A Sbjct 476 A 476 >RecName: Full=2-phosphinomethylmalate synthase; Short=PMS; AltName: Full=PMM synthase [Streptomyces hygroscopicus] Sequence ID: Q9LCB4.1 Length: 440 Range 1: 120 to 394 Score:95.1 bits(235), Expect:1e-19, Method:Compositional matrix adjust., Identities:88/284(31%), Positives:132/284(46%), Gaps:33/284(11%) Query 90 VDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSF-VIEYAIKSGLKINVYLEDW 148 V+ IK G LL+ S +H + G + + + A+ G++ V+LED Sbjct 120 VELIKRIGVIETGLLSSSSDYHTFHKFGSGGRTQAASMYLDAVTMALDHGIRPRVHLEDT 179 Query 149 SNGFRNSPDYVKSLVEHLSK-------EHIERIFLPDTLGVLSPEETFQGVDSLIQKYPD 201 + R+SPD+V++LVE + K E R + DTLG+ P + SL + P Sbjct 180 T---RSSPDFVRALVEEVLKTAERYPAELQPRFRVCDTLGIGLPYDDV----SLPRSIPR 232 Query 202 I------------HFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEAL 249 E H HND L VAN L AIR G + + G GER GN PLEA+ Sbjct 233 WIRLLRGFGLSPSQIELHPHNDTWLVVANCLAAIREGCGVISGTTLGTGERTGNAPLEAV 292 Query 250 VTTIHDKSNSKTNINEIAITEASRLVEVFS--GKRISANRPIVGEDVFTQTAGVHADG-D 306 + +H + + + ++LVE++ G S P G D + AG+HADG + Sbjct 293 M--VHLLGMGYWSGARVNLPAVNKLVELYEGIGAGPSQKYPFFGRDAYVTRAGIHADGLN 350 Query 307 KKGNLYANPILPERFGRKRSYALGKLAGKASISENV-KQLGMVL 349 K +YA P GR+ AL K +G+A + + K+LG+ L Sbjct 351 KFWWMYAPFNAPLLTGRELDVALTKDSGQAGLLFVLNKRLGLQL 394 >RecName: Full=Citrate (Re)-synthase; AltName: Full=Re-citrate synthase [Clostridium kluyveri DSM 555] Sequence ID: A5N6T4.1 Length: 453 Range 1: 46 to 387 Score:94.0 bits(232), Expect:2e-19, Method:Compositional matrix adjust., Identities:97/351(28%), Positives:153/351(43%), Gaps:28/351(7%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME 67 + I D T RDG+Q+ +++ E + I +L + N S + + E K Sbjct 46 IYITDTTFRDGQQSMP-PYTSREIVRIFDYLHELDN------NSGIIKQTEFFLYTKKDR 98 Query 68 WAA---TEQLTERIEILGFVDGNK-TVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 AA E+ E E+ ++ +K + +KD G K +L S +H+ K+L T KE Sbjct 99 KAAEVCMERGYEFPEVTSWIRADKEDLKLVKDMGIKETGMLMSCSDYHIFKKLKMTRKET 158 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIE-----RIFLPD 178 + A+ +G++ +LED + + +V V L K E +I D Sbjct 159 MDMYLDLAREALNNGIRPRCHLEDITRA--DFYGFVVPFVNELMKMSKEANIPIKIRACD 216 Query 179 TLGVLSPE---ETFQGVDSLIQ------KYPDIHFEFHGHNDYDLSVANSLQAIRAGVKG 229 TLG+ P E + V +I + P E+HGHND+ V NS A G Sbjct 217 TLGLGVPYNGVEIPRSVQGIIHGLRNICEVPSESIEWHGHNDFYGVVTNSSTAWLYGASS 276 Query 230 LHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPI 289 ++ S G+GER GN PLEA++ + N+ ITE ++ E + P Sbjct 277 INTSFLGIGERTGNCPLEAMIFEYAQIKGNTKNMKLHVITELAQYFEKEIKYSVPVRTPF 336 Query 290 VGEDVFTQTAGVHADGDKKGNLYANPILPER-FGRKRSYALGKLAGKASIS 339 VG D AG+HADG K N ++ GR A+ + +G+A I+ Sbjct 337 VGTDFNVTRAGIHADGILKDEEIYNIFDTDKILGRPVVVAVSQYSGRAGIA 387 >RecName: Full=2-isopropylmalate synthase 2; AltName: Full=Alpha-IPM synthase 2; AltName: Full=Alpha-isopropylmalate synthase 2 [Leptospira interrogans serovar Lai str. 56601] Sequence ID: Q8F8T4.1 Length: 428 Range 1: 42 to 341 Score:90.5 bits(223), Expect:3e-18, Method:Compositional matrix adjust., Identities:80/305(26%), Positives:136/305(44%), Gaps:11/305(3%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA 69 +DVTLRDG Q ++ +K I K LL KL V +E+ A + E E + + A Sbjct 42 FMDVTLRDGNQALRRPWNLEQKETIFKQLL-KLGVQGIEVGFASSNNQEFEACKYLSSIA 100 Query 70 ATEQLTERIEILGFVDGNKTVDW--IKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 + + V+ V W I+ + ++++ S ++ L +P++ + Sbjct 101 PDNVVISSLS--RAVEKEIEVSWKAIRFAPKPRIHIVYPVSAFTIQNVLKISPEKVLDRI 158 Query 128 SFVIEYA---IKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLS 184 S + YA + S ++ E + + N D+ + + + LP+T+ Sbjct 159 SQSVAYAKSLVGSKGEVQFSGEHFGDSLENL-DFAAEAFQIALNNGADVVNLPNTVERYR 217 Query 185 PEETFQGVDSLIQKYP-DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGN 243 P V ++ P D H HND ++ A ++++ AG L ++NGLGERAGN Sbjct 218 PWLFVSMVKAVANLLPEDTRISIHTHNDLGMATATTVESYFAGAVQLETALNGLGERAGN 277 Query 244 TPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHA 303 T + +H+ + +N I E SRLV S I P++GEDV + +G+H Sbjct 278 TNTYEVAIALHN-CGVEVPLNFSTIYETSRLVSYLSEIPIYEKAPLIGEDVISHRSGIHQ 336 Query 304 DGDKK 308 DG K Sbjct 337 DGVAK 341 >RecName: Full=Citrate (Re)-synthase; AltName: Full=Re-citrate synthase [Syntrophus aciditrophicus SB] Sequence ID: Q2LTE1.2 Length: 629 Range 1: 61 to 365 Score:85.1 bits(209), Expect:3e-16, Method:Compositional matrix adjust., Identities:77/311(25%), Positives:143/311(45%), Gaps:21/311(6%) Query 10 ILDVTLRDGEQTRGVSFSTSEKLNIAKFL--LQKLNVDRVEIASARVSKGELETVQKIME 67 I D T RDG+Q R ++T + +++ + + L N + S + E V+ + Sbjct 61 ITDTTFRDGQQARP-PYTTQQIVDLYQMMSRLGGYNGIIRQTEFFLYSNRDKEAVRMCQD 119 Query 68 WAATEQLTERIEILGFVDGNK-TVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + EI G++ + + +K++G K +LT S +H+ +L T + + Sbjct 120 LG-----LQYPEITGWIRAAREDIPLVKEAGLKETGILTSVSDYHIFLKLNMTRSQALEE 174 Query 127 VSFVIEYAIKSGLKINVYLEDWSNG--FRNSPDYVKSLVEHLSKEHIE-RIFLPDTLG-- 181 +++ + +G+ + ED + + + L++ + ++ +I L DT+G Sbjct 175 YLGIVKAILDAGIVPRCHFEDITRADIYGFCIPFAIELMKLREESGVDIKIRLCDTMGYG 234 Query 182 VLSPEETF-QGVDSLIQKY------PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 V P + +GVD L++ + P E+HGHND+ ++ N+ A G ++++ Sbjct 235 VTYPGASLPRGVDKLVRAFIDDADVPGRLLEWHGHNDFHKALINATTAWLYGCSAANSTL 294 Query 235 NGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDV 294 GLGER GN P+E L+ I+ IT+ + + +I +N P VG D Sbjct 295 LGLGERTGNPPIEGLIIEYIGLMGKTNGIDTTVITDIANYFKNEIEYKIPSNYPFVGADF 354 Query 295 FTQTAGVHADG 305 AGVHADG Sbjct 355 NVTRAGVHADG 365 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Rhodococcus jostii RHA1] Sequence ID: Q0S815.1 Length: 339 Range 1: 145 to 262 Score:70.9 bits(172), Expect:5e-12, Method:Compositional matrix adjust., Identities:40/119(34%), Positives:64/119(53%), Gaps:2/119(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYD 213 +P+ + ++ + +++ D+ G L E+ V++L+Q+ D FHGH + Sbjct 145 APEKLAKQARIMADAGCQCVYVVDSAGALVLEQVSDRVEALVQELGSDAQVGFHGHENLG 204 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 L VANS+ A+RAG K + S G AGN P+EA V + DK KT I+ AI +A+ Sbjct 205 LGVANSIAAVRAGAKQIDGSTRRFGAGAGNAPVEAFV-GVCDKIGVKTGIDFFAIADAA 262 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Rhodococcus opacus B4] Sequence ID: C1BAJ4.1 Length: 339 Range 1: 146 to 262 Score:70.1 bits(170), Expect:8e-12, Method:Compositional matrix adjust., Identities:40/118(34%), Positives:63/118(53%), Gaps:2/118(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E+ V++L+Q+ D FHGH + L Sbjct 146 PEKLARQARIMADAGCQCVYVVDSAGALVLEQVSDRVEALVQELGADAQVGFHGHENLGL 205 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 VANS+ A+RAG K + S G AGN P+EA V + DK KT I+ AI +A+ Sbjct 206 GVANSIAAVRAGAKQIDGSTRRFGAGAGNAPVEAFV-GVCDKIGVKTGIDFFAIADAA 262 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 6; Short=HOA 6; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 6; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 6 [Rhodococcus jostii RHA1] Sequence ID: Q0RXC3.1 Length: 354 Range 1: 1 to 268 Score:69.7 bits(169), Expect:1e-11, Method:Compositional matrix adjust., Identities:83/295(28%), Positives:133/295(45%), Gaps:47/295(15%) Query 1 MTKVETR--LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIAS------- 51 MT+ E R + I+D TLRDG + F+ S+ + + L V+ +E+ Sbjct 1 MTRPELRDDVRIVDTTLRDGSHAQSHQFTESQVRDTVR-ALDGAGVEVIEVTHGDGLGGS 59 Query 52 ------ARVSKGELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIK---DSGAKVLN 102 +R+S +LE VQ + A EQ +I +L V G T D ++ D GA+V+ Sbjct 60 TFNYGFSRIS--DLELVQVAADTA--EQ--AKIAVL-LVPGIGTADDLRKAADRGAEVVR 112 Query 103 LLTKGSLHHLEKQLGKTPKEFFTDVSFV-IEYAIKSGLKINVYLEDWSNGFRNSPDYVKS 161 + T H E DVS E A G++ +L R +P+ + Sbjct 113 IAT----HCTE-----------ADVSLQHFEIARDLGMQTCGFL---MMAHRTTPEELAR 154 Query 162 LVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHF-EFHGHNDYDLSVANSL 220 + + ++ D+ G L E D+LI + D + +HGH + L VANS+ Sbjct 155 QARLMVDAGCQVPYVTDSAGALLMHEAKDRFDALITEVGDDAWVGYHGHQNMSLGVANSV 214 Query 221 QAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLV 275 A AGV+ + S+ LG AGN+P E L+ I D+ N T ++ +A +A+ V Sbjct 215 IAYEAGVRYIDGSLCALGAGAGNSPTE-LLAAIFDRMNIATGLDVMATLDAAETV 268 >RecName: Full=Citrate (Re)-synthase; AltName: Full=Re face-specific citrate synthase; AltName: Full=Re-citrate synthase [Dehalococcoides mccartyi CBDB1] Sequence ID: P0DO96.1 Length: 415 Range 1: 3 to 311 Score:70.1 bits(170), Expect:1e-11, Method:Compositional matrix adjust., Identities:85/328(26%), Positives:140/328(42%), Gaps:48/328(14%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 ++ I+DVT RDG QT + S EK + L ++ + + E +K E V+ + Sbjct 3 KIFIIDVTNRDGVQTARLGLSKLEK-TLINIYLDEMGIFQSEFGFP-TTKHERGYVEANL 60 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKV-LNLLTKGSLHHLEKQLG-------- 117 E A +G + + WI+ A V L SL HL + Sbjct 61 ELAK----------MGVIKNLRLEGWIRAIVADVDLAFRRAPSLKHLNLSISTSEQMING 110 Query 118 -----KTPKEFFTDVSFVIEYAIKSGLK-INVYLEDWSNGFRNSPDYVKSLVEH--LSKE 169 K K+ D++ + A G + + V ED S R S + +L+E +KE Sbjct 111 KFQGRKVFKDIIEDMTIAVNAAYAKGAETVGVNAEDAS---RTS---IVNLIEFGKAAKE 164 Query 170 -HIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVK 228 R+ DTLG +P ++ +L +K + E H H D +++ NSL + + Sbjct 165 VGATRLRYCDTLGYDNPFTIYETARTLAEKV-GMPIEIHCHGDLGMAIGNSLAGAKGVID 223 Query 229 G-----LHASINGLGERAGNTPLEALVTTIHDKSNSKTNI---NEIAITEA---SRLVEV 277 G ++ ++NG+GERAGN L A + I +E+ +++A +R Sbjct 224 GGQDVYVNTTVNGIGERAGNADLVAFLLAILKSKGFGEKYQLGHEVDLSKAWKIARFASY 283 Query 278 FSGKRISANRPIVGEDVFTQTAGVHADG 305 I N+P VG + F +G+HADG Sbjct 284 AFDVEIPINQPGVGRNCFAHASGIHADG 311 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Rhodococcus erythropolis PR4] Sequence ID: C0ZPX1.1 Length: 347 Range 1: 152 to 268 Score:69.7 bits(169), Expect:1e-11, Method:Compositional matrix adjust., Identities:40/118(34%), Positives:63/118(53%), Gaps:2/118(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYP-DIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E+ V++L+Q+ D FHGH + L Sbjct 152 PEKLAKQARIMADAGCQCVYVVDSAGALVLEQVSDRVEALVQELGNDAQVGFHGHENLGL 211 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 VANS+ A+RAG K + S G AGN P+EA V + DK KT I+ AI +A+ Sbjct 212 GVANSIAAVRAGAKQIDGSTRRFGAGAGNAPVEAFV-GVCDKIGVKTGIDFFAIADAA 268 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Nocardia farcinica IFM 10152] Sequence ID: Q5Z2N2.1 Length: 345 Range 1: 148 to 264 Score:69.3 bits(168), Expect:2e-11, Method:Compositional matrix adjust., Identities:40/118(34%), Positives:64/118(54%), Gaps:2/118(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E+ V +++ + D FHGH + DL Sbjct 148 PEVLAKQARIMADAGCQCVYIVDSAGALVLEQVSDRVAAVVAELGDDAQVGFHGHENLDL 207 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 +VANS+ AIRAG + S G AGNTP+EALV + DK +T I+ AI +A+ Sbjct 208 AVANSIYAIRAGATQIDGSARRFGAGAGNTPVEALV-GVCDKLGIRTGIDFFAIADAA 264 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Streptomyces coelicolor A3(2)] Sequence ID: Q99PZ1.1 Length: 338 Range 1: 144 to 263 Score:68.2 bits(165), Expect:3e-11, Method:Compositional matrix adjust., Identities:38/122(31%), Positives:64/122(52%), Gaps:2/122(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDL 214 +PD + + + + + + + D+ G PE+ + ++ D+ FHGHN+ + Sbjct 144 APDELAAQCQRMVGYGAQAVCIFDSAGTYLPEDVTARITAITTAV-DVPVAFHGHNNLGM 202 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRL 274 +VANSL A+RAG + L A G G AGNT LE LV + ++ T I+ + +A+ L Sbjct 203 AVANSLAAVRAGARVLDACARGFGAGAGNTQLEVLVAVL-ERYGHPTGIDLRLVAQAADL 261 Query 275 VE 276 E Sbjct 262 AE 263 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Desulfitobacterium hafniense Y51] Sequence ID: Q24PE3.1 Length: 557 Range 1: 34 to 552 Score:68.9 bits(167), Expect:3e-11, Method:Compositional matrix adjust., Identities:121/541(22%), Positives:216/541(39%), Gaps:61/541(11%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEW-A 69 V LRDG Q V S EKL LL K+ +E+ S+ E ++ ++E Sbjct 34 CSVDLRDGNQALVVPMSLEEKLEYYHMLL-KIGFKEIEVGFPAASETEYAFLRTLIEQNL 92 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH-HLEKQLGKTPKEFFTDVS 128 E +T I++L ++ D I + K L + K +H + + + + F Sbjct 93 IPEDVT--IQVL-----TQSRDHIIEKTFKALVGVKKAVVHLYNSTSVAQREQVFKMSRE 145 Query 129 FVIEYAIKSGLKINVYLEDWSNGFR--NSPDYVKSLVEHLSKEHIERIF----------- 175 ++E A+ + Y + F+ SP+ + E ++ Sbjct 146 EIVEIAVSGARLLKKYAAETEGNFQFEYSPESFTGTEMEFALEICNQVLDVFEPTPENKV 205 Query 176 ---LPDTLGVLSPEETFQGVDSLIQ--KYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKG 229 LP T+ + P ++ + + KY D + H HND +VA++ + AG + Sbjct 206 IINLPATVSLSMPHVYASQIEYMSEHLKYRDNVILSLHPHNDRGTAVADAELGLLAGGQR 265 Query 230 LHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPI 289 + ++ G GER GN + L + +N ++ E + E + ++ +P Sbjct 266 IEGTLFGNGERTGNVDIVTLALNLFSHG-VDPGLNFASMLEITAKYEALTRMKVHDRQPY 324 Query 290 VGEDVFTQTAGVHADGDKKG---------NLYANPIL---PERFGRKRS---YALGKLAG 334 G+ VF +G H D KG + + P L P+ GR+ + +G Sbjct 325 GGKLVFAAFSGSHQDAITKGIKWREEHECHYWNVPYLLIDPQDIGREYEGDVIRINSQSG 384 Query 335 KASISENVKQ-LGMVLSEVVLQKVLERVIELGDQ-NKLVTPEDLPFIIADVSGRTGEKVL 392 K I+ ++Q + L + + +V + D +K + PE+ I D+ + + Sbjct 385 KGGIAYMLEQHYALDLPAKMREAFGYKVKNVSDNLHKELMPEE----IKDIFFKEYVNIE 440 Query 393 T-IKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKL 451 IK N H + LE++G+I + EGDG DA NAL RLG+S L Sbjct 441 NPIKFLNFHFLNHDDFQTTVTLEFKGEIQELSGEGDGRLDAISNALQA---RLGLSYSNL 497 Query 452 IDYEVRIPPGGKTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQIL 511 I E + G K+ A+ +T + G+H D ++V A +N ++ Sbjct 498 IYKEHALELGSKSQAVSYVGVTGPDGV------IHWGCGIHTDIFTSSVKALISAINTMI 551 Query 512 Q 512 + Sbjct 552 K 552 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Desulfitobacterium hafniense DCB-2] Sequence ID: B8G187.1 Length: 333 Range 1: 3 to 249 Score:66.6 bits(161), Expect:1e-10, Method:Compositional matrix adjust., Identities:65/266(24%), Positives:113/266(42%), Gaps:27/266(10%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIM 66 +++I D+TLRDG + F+ + +A+ +D +A+ G + Sbjct 3 KVKIFDLTLRDGSHAKSHQFTPEQMAVLAE------QIDSTGVAAIEFGHGNGLGGSALQ 56 Query 67 EWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLH--HLEKQLGKTPKEFF 124 A E +E + V +K++ ++ L G+ H HL K+ G Sbjct 57 YGFAAATDREYMEAVAPV--------VKNADLSIIILPGVGTRHELHLAKEFGAKYARMC 108 Query 125 TDVSFV------IEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T ++ V I+ A + G+ L G D V+ + E I+L D Sbjct 109 TQITEVDIAEQHIKMAKQLGMIPIAVLP--CAGIIPVKDTVR-YTQMAESYGAEVIYLLD 165 Query 179 TLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLG 238 G PE+T++ + ++ +K D+ FHGHN+ L+VANS A+ AG + + + G G Sbjct 166 GGGYQLPEQTYERIAAM-KKAVDVPIGFHGHNNLQLAVANSKAAVEAGAEYIDCCLKGFG 224 Query 239 ERAGNTPLEALVTTIHDKSNSKTNIN 264 AGN P E + + D+ I+ Sbjct 225 AGAGNCPTE-IFAAVMDRMEIDCGID 249 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Mycolicibacterium gilvum PYR-GCK] Sequence ID: A4T7U4.1 Length: 352 Range 1: 152 to 272 Score:66.2 bits(160), Expect:1e-10, Method:Compositional matrix adjust., Identities:40/122(33%), Positives:63/122(51%), Gaps:2/122(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYD 213 SP+ + ++ + +++ D+ G L E V +L+ + D FHGH + Sbjct 152 SPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVSALVAELGDDAQVGFHGHENLG 211 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASR 273 L VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 212 LGVANSIEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAE 270 Query 274 LV 275 V Sbjct 271 EV 272 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Acetoanaerobium sticklandii DSM 519] Sequence ID: E3PVH7.1 Length: 567 Range 1: 23 to 499 Score:67.0 bits(162), Expect:2e-10, Method:Compositional matrix adjust., Identities:117/497(24%), Positives:210/497(42%), Gaps:65/497(13%) Query 3 KVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV 62 K+E + V LRDG Q +KL ++L+ K+ +EI S E E Sbjct 23 KIEKAPQWCSVDLRDGNQALITPMGLKQKLRFFEYLV-KMGFKTIEIGFPAASDTEYEFT 81 Query 63 QKIMEWAATEQ------LTE-RIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQ 115 + ++E + LT+ RI+I+ NKT + +K + V++L S E Sbjct 82 RTLIEEGYIPEDVTIQVLTQSRIQII-----NKTFEALKGTKNAVVHLYNSTSTLQREVV 136 Query 116 LGKTPKEFFTDVSF----VIEYAIKSGLKINVYLEDWSNGFRNSP-DYVKSLVEHL---- 166 + +E F + E A+K+ + N E F + D+ + + Sbjct 137 FRNSKEETIELAVFGARAIKELALKNP-ETNFTFEYSPESFTGTEMDFAAEICNSVIDVW 195 Query 167 --SKEHIERIFLPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQ 221 +K+ I LP T+ + +P ++ + ++ +I H HND VA + Sbjct 196 KPTKDKKVIINLPSTVEMATPNTYADQIEYMCRNLKSRENIIVSLHAHNDRGTGVAATEL 255 Query 222 AIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNIN-EIAITEASRLVEVF-- 278 + AG + ++ G GER GN + L ++ + IN E+ ++ + ++E++ Sbjct 256 GLMAGADRVEGTLFGNGERTGNADILNLGMNLYTQG-----INPELDFSDINSMIEIYEE 310 Query 279 -SGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYAN-----------PILPERFGRKRS 326 + + P G+ VFT +G H D KKG N P+ P+ G +S Sbjct 311 STAMNVHPRHPYAGDLVFTAFSGSHQDAIKKGMARMNKQAQYWEVPYLPLDPKDIG--KS 368 Query 327 YA----LGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVT---PEDLP-- 377 Y + +GK +S ++Q + QK RVI +K+ T E++ Sbjct 369 YEPIIRINSQSGKGGVSFILEQNYGLYIPKDFQKDAGRVI-TAYSDKMQTEIGAEEIYEV 427 Query 378 FIIADVSGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNAL 437 F+ V RT ++ K+ ++ S + + E+EY + H +EG+G AF N+L Sbjct 428 FLNEYVDIRTPLQLNYHKTQSVDSDWDL-VFIEAEIEYNMQKHYVQAEGNGVVSAFCNSL 486 Query 438 TKITNRLGISIPKLIDY 454 +I +G+ I ++DY Sbjct 487 KEI---IGMDI-DIVDY 499 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Mycolicibacterium smegmatis MC2 155] Sequence ID: A0R4S6.1 Length: 349 Range 1: 150 to 270 Score:65.9 bits(159), Expect:2e-10, Method:Compositional matrix adjust., Identities:40/122(33%), Positives:63/122(51%), Gaps:2/122(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYD 213 SP+ + ++ + +++ D+ G L E V +L+ + D FHGH + Sbjct 150 SPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVQALVAELGSDAQVGFHGHENLG 209 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASR 273 L VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 210 LGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAE 268 Query 274 LV 275 V Sbjct 269 EV 270 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Mycobacterium ulcerans Agy99] Sequence ID: A0PUX2.1 Length: 347 Range 1: 145 to 262 Score:65.5 bits(158), Expect:3e-10, Method:Compositional matrix adjust., Identities:37/119(31%), Positives:64/119(53%), Gaps:2/119(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYD 213 +P+ + + ++ + +++ D+ G L + V +L+ + D FHGH + Sbjct 145 APEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAALVAELGEDAQVGFHGHENLG 204 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 L VANS++A+RAG K + S+ G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 205 LGVANSVEAVRAGAKQIDGSVRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAA 262 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Mycobacterium marinum M] Sequence ID: B2HI25.1 Length: 347 Range 1: 145 to 262 Score:65.5 bits(158), Expect:3e-10, Method:Compositional matrix adjust., Identities:37/119(31%), Positives:64/119(53%), Gaps:2/119(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYD 213 +P+ + + ++ + +++ D+ G L + V +L+ + D FHGH + Sbjct 145 APEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAALVAELGEDAQVGFHGHENLG 204 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 L VANS++A+RAG K + S+ G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 205 LGVANSVEAVRAGAKQIDGSVRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAA 262 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Marinomonas sp. MWYL1] Sequence ID: A6W1X1.1 Length: 339 Range 1: 164 to 244 Score:64.7 bits(156), Expect:4e-10, Method:Compositional matrix adjust., Identities:32/81(40%), Positives:48/81(59%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 ++ D+ G + P+E + +L P I FHGH++ L VANS+ AI++G + + Sbjct 164 VYCTDSAGYMLPDEVSLKISALRDTLPSSIDIGFHGHHNLALGVANSVAAIQSGARRIDG 223 Query 233 SINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE LV + Sbjct 224 SVAGLGAGAGNTPLEVLVAVM 244 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Mycolicibacterium vanbaalenii PYR-1] Sequence ID: A1TFQ5.1 Length: 350 Range 1: 153 to 272 Score:64.3 bits(155), Expect:6e-10, Method:Compositional matrix adjust., Identities:39/121(32%), Positives:62/121(51%), Gaps:2/121(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E V +L+ + D FHGH + L Sbjct 153 PEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVAALVAELGSDAQVGFHGHENLGL 212 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRL 274 VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 213 GVANSIEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAEE 271 Query 275 V 275 V Sbjct 272 V 272 >RecName: Full=Homocitrate synthase, omega subunit [Clostridium pasteurianum] Sequence ID: Q00852.1 Length: 352 Range 1: 171 to 331 Score:64.3 bits(155), Expect:7e-10, Method:Compositional matrix adjust., Identities:42/165(25%), Positives:78/165(47%), Gaps:4/165(2%) Query 205 EFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNIN 264 +F N Y+++ A + A G + N A +E ++ + N + + Sbjct 171 DFCASNKYNMATAIIINAFLNGSDIITTEFNSNDYAA----MEEVIIALKSIRNIEIRGD 226 Query 265 EIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGRK 324 I++ +R+ E + +R+ + +PI+GED+F +G+HADG K P PE G Sbjct 227 LKLISKLTRIYEKITSERVYSMKPILGEDIFKYESGIHADGIAKNPKNYEPFNPELIGTN 286 Query 325 RSYALGKLAGKASISENVKQLGMVLSEVVLQKVLERVIELGDQNK 369 R +GK +GKA++ K+L + + + + L+ + E Q K Sbjct 287 RKLYIGKHSGKAALVVKFKELNLNCNNIDMNLFLQDIREKSIQEK 331 >RecName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase; AltName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2] Sequence ID: A1KPL9.1 Length: 346 >RecName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase; AltName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA [Mycobacterium tuberculosis H37Ra] Sequence ID: A5U8K8.1 Length: 346 >RecName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase; AltName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172] Sequence ID: C1AHZ2.1 Length: 346 >RecName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase; AltName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA [Mycobacterium tuberculosis CDC1551] Sequence ID: P9WMK4.1 Length: 346 >RecName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase; AltName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA [Mycobacterium tuberculosis H37Rv] Sequence ID: P9WMK5.1 Length: 346 >RecName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase; AltName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA [Mycobacterium tuberculosis variant bovis AF2122/97] Sequence ID: Q7TW97.1 Length: 346 Range 1: 145 to 262 Score:63.9 bits(154), Expect:7e-10, Method:Compositional matrix adjust., Identities:37/119(31%), Positives:62/119(52%), Gaps:2/119(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYD 213 +P+ + + ++ + +++ D+ G L + V +L+ + D FHGH + Sbjct 145 APEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLG 204 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 L VANS+ A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 205 LGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAA 262 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Salinispora arenicola CNS-205] Sequence ID: A8M6W8.1 Length: 348 Range 1: 161 to 242 Score:63.9 bits(154), Expect:9e-10, Method:Compositional matrix adjust., Identities:32/83(39%), Positives:46/83(55%), Gaps:1/83(1%) Query 172 ERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLH 231 E + L D+ G +PE + V L++K DI FH HN+ LSV NS+ A+RAG + Sbjct 161 EAVVLMDSAGAYTPEMVREKVGELVEKL-DIAIGFHAHNNLGLSVINSITAVRAGASIVD 219 Query 232 ASINGLGERAGNTPLEALVTTIH 254 + G G AGN P+E + +H Sbjct 220 VTARGFGAGAGNAPIELVAANLH 242 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Mycobacterium sp. JLS] Sequence ID: A3Q6M9.1 Length: 353 Range 1: 153 to 272 Score:63.9 bits(154), Expect:9e-10, Method:Compositional matrix adjust., Identities:39/121(32%), Positives:62/121(51%), Gaps:2/121(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E V +L+ + D FHGH + L Sbjct 153 PEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGSDAQVGFHGHENLGL 212 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRL 274 VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 213 GVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAEE 271 Query 275 V 275 V Sbjct 272 V 272 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Mycobacterium avium 104] Sequence ID: A0QAG9.1 Length: 352 Range 1: 152 to 271 Score:63.5 bits(153), Expect:1e-09, Method:Compositional matrix adjust., Identities:39/121(32%), Positives:62/121(51%), Gaps:2/121(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E V +L+ + D FHGH + L Sbjct 152 PEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGL 211 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRL 274 VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 212 GVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAEE 270 Query 275 V 275 V Sbjct 271 V 271 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Mycobacterium avium subsp. paratuberculosis K-10] Sequence ID: Q743Q8.1 Length: 352 Range 1: 152 to 271 Score:63.5 bits(153), Expect:1e-09, Method:Compositional matrix adjust., Identities:39/121(32%), Positives:62/121(51%), Gaps:2/121(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E V +L+ + D FHGH + L Sbjct 152 PEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGL 211 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRL 274 VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 212 GVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAEE 270 Query 275 V 275 V Sbjct 271 V 271 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Mycobacterium sp. JLS] Sequence ID: A3Q4B9.1 Length: 363 Range 1: 152 to 271 Score:63.5 bits(153), Expect:1e-09, Method:Compositional matrix adjust., Identities:39/121(32%), Positives:62/121(51%), Gaps:2/121(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E V +L+ + D FHGH + L Sbjct 152 PEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGL 211 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRL 274 VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 212 GVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAEE 270 Query 275 V 275 V Sbjct 271 V 271 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 5; Short=HOA 5; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 5; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 5 [Dechloromonas aromatica RCB] Sequence ID: Q479E5.1 Length: 354 Range 1: 148 to 248 Score:63.5 bits(153), Expect:1e-09, Method:Compositional matrix adjust., Identities:33/101(33%), Positives:54/101(53%), Gaps:1/101(0%) Query 154 NSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDY 212 N+P+ + + + + +++ D+ G + P + V +L P+ FHGH++ Sbjct 148 NTPEGLAQQGKLMESYGAQTVYITDSAGYMLPGDVKARVSALRDVLKPETEIGFHGHHNM 207 Query 213 DLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTI 253 + +ANS+ AI AG + AS+ GLG AGNTPLEA V Sbjct 208 GMGIANSIAAIEAGASRIDASVGGLGAGAGNTPLEAFVAVC 248 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Mycobacterium sp. KMS] Sequence ID: A1UM80.1 Length: 353 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Mycobacterium sp. MCS] Sequence ID: Q1B2X1.1 Length: 353 Range 1: 153 to 272 Score:63.5 bits(153), Expect:1e-09, Method:Compositional matrix adjust., Identities:39/121(32%), Positives:62/121(51%), Gaps:2/121(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L E V +L+ + D FHGH + L Sbjct 153 PEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGL 212 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRL 274 VANS++A+RAG K + S G AGN P+EAL+ + DK KT I+ I +A+ Sbjct 213 GVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALI-GVFDKIGVKTGIDFFDIADAAEE 271 Query 275 V 275 V Sbjct 272 V 272 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Alkalilimnicola ehrlichii MLHE-1] Sequence ID: Q0A5T5.1 Length: 342 Range 1: 164 to 244 Score:63.2 bits(152), Expect:2e-09, Method:Compositional matrix adjust., Identities:30/81(37%), Positives:46/81(56%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKYPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +++ D+ G + PEE + V +L + D FHGH++ + VANS+ A+ AG K + Sbjct 164 VYMTDSAGYMLPEEVREKVSALREGLADETEVGFHGHHNLAMGVANSVAAVEAGAKRIDG 223 Query 233 SINGLGERAGNTPLEALVTTI 253 S+ G G AGNTPLE + Sbjct 224 SVAGFGAGAGNTPLEVFIAVC 244 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Thermus thermophilus HB8] Sequence ID: Q53WI0.1 Length: 347 Range 1: 150 to 268 Score:62.4 bits(150), Expect:2e-09, Method:Compositional matrix adjust., Identities:31/120(26%), Positives:60/120(50%), Gaps:1/120(0%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLS 215 P+++ + + +++ D+ G + PE+ + V +L + FH HN+ L+ Sbjct 150 PEFLAEQARLMEGYGADVVYIVDSAGAMLPEDAYARVKALKEALSRAKVGFHAHNNLGLA 209 Query 216 VANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLV 275 + N+L A+ AG + A++ G G AGN PLE L + DK+ ++ + +A+ V Sbjct 210 IGNTLAALAAGADWVDATLRGYGAGAGNAPLEVLAAVL-DKAGLNPGLDVFKLLDAAEYV 268 >RecName: Full=Oxaloacetate decarboxylase; Short=OAA decarboxylase [Mycobacterium tuberculosis H37Rv] Sequence ID: O06334.1 Length: 336 Range 1: 125 to 248 Score:62.4 bits(150), Expect:2e-09, Method:Compositional matrix adjust., Identities:38/128(30%), Positives:68/128(53%), Gaps:4/128(3%) Query 131 IEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQ 190 +E A GL++++ L S+ F PD + + + + +++ DT G PE+ + Sbjct 125 VERAQSKGLEVSIQLVK-SHLF--EPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARR 181 Query 191 GVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALV 250 V++L + D+ FHGHN+ ++VAN+L+A AG L ++ G G AGN +E LV Sbjct 182 YVEAL-RGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLV 240 Query 251 TTIHDKSN 258 + + + Sbjct 241 AALQRRGH 248 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Shewanella pealeana ATCC 700345] Sequence ID: A8H4E9.1 Length: 340 Range 1: 146 to 245 Score:62.0 bits(149), Expect:3e-09, Method:Compositional matrix adjust., Identities:34/100(34%), Positives:53/100(53%), Gaps:1/100(1%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYD 213 SPD + + + I+ D+ G + P + ++ L + D FHGH++ Sbjct 146 SPDKLLEQAKLMESYGANCIYCTDSAGYMLPGDVTSHIERLRGELKSDTQIGFHGHHNMG 205 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTI 253 +S+ANSL AI+AG + + S+ GLG AGNTPLE V + Sbjct 206 MSIANSLAAIQAGAERIDGSVAGLGAGAGNTPLEVFVAVL 245 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Stutzerimonas stutzeri] Sequence ID: Q9ZI56.1 Length: 346 Range 1: 165 to 245 Score:62.0 bits(149), Expect:3e-09, Method:Compositional matrix adjust., Identities:31/81(38%), Positives:45/81(55%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I+ D+ G + P+E + + L + P FHGH++ +++ANSL AI AG + Sbjct 165 IYCTDSAGYMLPDEVSEKIGLLRAELNPATEIGFHGHHNMGMAIANSLAAIEAGASRIDG 224 Query 233 SINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE V Sbjct 225 SVAGLGAGAGNTPLEVFVAVC 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bordetella petrii DSM 12804] Sequence ID: A9HW07.1 Length: 568 Range 1: 212 to 522 Score:62.8 bits(151), Expect:4e-09, Method:Compositional matrix adjust., Identities:82/322(25%), Positives:135/322(41%), Gaps:36/322(11%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ +P + + + + + I H HND +VA + A+ AG + Sbjct 212 LPATIEATTPNLYADQIEWMHKNLARRDSIVLSVHPHNDRGTAVAAAEFAVMAGADRIEG 271 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L ++ + ++ I E R E + + P G+ Sbjct 272 CLFGSGERTGNVDLVTLALNLYTQ-GVHPGLDFSDIDEVRRCAEYCNQLPVHPRHPYAGD 330 Query 293 DVFTQTAGVHADGDKKGNLYAN----------PILPERFGRKRSYAL--GKLAGKASISE 340 VFT +G H D KKG PI P GR + +GK +S Sbjct 331 LVFTAFSGSHQDAIKKGFAQQKPDAVWEVPYLPIDPADLGRSYDAVIRVNSQSGKGGVSY 390 Query 341 NVKQ-LGMVLS---EVVLQKVLERVIELGDQNKLVTPEDLPFIIAD--VSGRTGEKVLTI 394 ++Q G+VL ++ + ++RV + + + VT +D+ I + + K++ Sbjct 391 LLEQEHGLVLPRRLQIEFSRAIQRVTD--ETGREVTADDVHTIFNREYLEQHSPWKLVRH 448 Query 395 K-SCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLID 453 + + G G + Q+EL+Y G+ GDG AF+ A LGI + +++D Sbjct 449 RIDGDPAGGQGKQFSIQVELDYNGERRVVTGSGDGAISAFVAA-------LGIPV-RIMD 500 Query 454 Y-EVRIPPGGKTDA--LVETRI 472 Y E I G T A VE R+ Sbjct 501 YHEHAIGTGTDTRAASYVELRV 522 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Pseudomonas putida] Sequence ID: P51017.1 Length: 346 Range 1: 165 to 245 Score:61.6 bits(148), Expect:4e-09, Method:Compositional matrix adjust., Identities:31/81(38%), Positives:45/81(55%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I+ D+ G + P+E + + L + P FHGH++ +++ANSL AI AG + Sbjct 165 IYCTDSAGYMLPDEVSEKIGLLRAELNPATEVGFHGHHNMGMAIANSLAAIEAGAARIDG 224 Query 233 SINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE V Sbjct 225 SVAGLGAGAGNTPLEVFVAVC 245 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Burkholderia pseudomallei 1710b] Sequence ID: Q3JK55.1 Length: 347 Range 1: 141 to 261 Score:60.8 bits(146), Expect:8e-09, Method:Compositional matrix adjust., Identities:40/123(33%), Positives:61/123(49%), Gaps:2/123(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLS 215 PD + + + + + + + L D+ G +P V+ L+ DI FH HN+ L+ Sbjct 141 PDALLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLVDGL-DIDVGFHAHNNLGLA 199 Query 216 VANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLV 275 VANSL A+ AG + + A + G G AGNT LE LV + + + E +T A R Sbjct 200 VANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAMEREGHDTRTTFERVMTLA-RGT 258 Query 276 EVF 278 E F Sbjct 259 ETF 261 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Burkholderia pseudomallei K96243] Sequence ID: Q63JB1.1 Length: 347 Range 1: 141 to 261 Score:60.8 bits(146), Expect:8e-09, Method:Compositional matrix adjust., Identities:40/123(33%), Positives:61/123(49%), Gaps:2/123(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLS 215 PD + + + + + + + L D+ G +P V+ L+ DI FH HN+ L+ Sbjct 141 PDALLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLVDGL-DIDVGFHAHNNLGLA 199 Query 216 VANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLV 275 VANSL A+ AG + + A + G G AGNT LE LV + + + E +T A R Sbjct 200 VANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAMEREGHDTRTTFERVMTLA-RGT 258 Query 276 EVF 278 E F Sbjct 259 ETF 261 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Shewanella halifaxensis HAW-EB4] Sequence ID: B0TTS9.1 Length: 340 Range 1: 165 to 245 Score:60.8 bits(146), Expect:8e-09, Method:Compositional matrix adjust., Identities:31/81(38%), Positives:46/81(56%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I+ D+ G + P + ++ L + D FHGH++ +S+ANSL AI AG + + Sbjct 165 IYCTDSAGYMLPGDVTSHIERLRGELKSDTQIGFHGHHNMGMSIANSLAAIEAGAERIDG 224 Query 233 SINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE V + Sbjct 225 SVAGLGAGAGNTPLEVFVAVL 245 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Burkholderia pseudomallei 668] Sequence ID: A3NML2.1 Length: 347 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Burkholderia pseudomallei 1106a] Sequence ID: A3P825.1 Length: 347 Range 1: 141 to 261 Score:60.8 bits(146), Expect:8e-09, Method:Compositional matrix adjust., Identities:40/123(33%), Positives:61/123(49%), Gaps:2/123(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLS 215 PD + + + + + + + L D+ G +P V+ L+ DI FH HN+ L+ Sbjct 141 PDTLLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLVDGL-DIDVGFHAHNNLGLA 199 Query 216 VANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLV 275 VANSL A+ AG + + A + G G AGNT LE LV + + + E +T A R Sbjct 200 VANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAMEREGHDTRTTFERVMTLA-RGT 258 Query 276 EVF 278 E F Sbjct 259 ETF 261 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088] Sequence ID: B7GT76.1 Length: 638 Range 1: 77 to 398 Score:61.2 bits(147), Expect:1e-08, Method:Compositional matrix adjust., Identities:80/332(24%), Positives:134/332(40%), Gaps:32/332(9%) Query 13 VTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATE 72 V LRDG Q + KL LL + +E+ S+ + + ++ ++E E Sbjct 77 VDLRDGNQALVNPMDSERKLRFWN-LLVSMGFKEIEVGFPSASETDFDFIRMLIE---RE 132 Query 73 QLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKE---FF 124 + + + I+ +T + +K + +++ S+ E K +E Sbjct 133 LIPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEEIKKLA 192 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNS-PDYVKSLVEHL------SKEHIERIFLP 177 TD + + + I++Y E F + P+Y + + + EH I LP Sbjct 193 TDAAELCKDLENEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIKPTPEHPMIINLP 252 Query 178 DTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 T+ + +P + + V + + + H HND + VA + A+ AG + + Sbjct 253 ATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADRVEGCL 312 Query 235 NGLGERAGNTPLEAL----VTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 G GER GN L L +T D +N+ EI T VE + +IS P Sbjct 313 LGNGERTGNVDLVTLGLNWLTQGIDPQLDLSNVPEIRKT-----VEYCNQIKISERHPYA 367 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPERFG 322 G VFT +G H D KKG L A + ER G Sbjct 368 GNFVFTAFSGSHQDAIKKG-LEARQVAAERAG 398 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Paraburkholderia xenovorans LB400] Sequence ID: Q13WM0.1 Length: 572 Range 1: 34 to 351 Score:60.8 bits(146), Expect:1e-08, Method:Compositional matrix adjust., Identities:82/335(24%), Positives:137/335(40%), Gaps:47/335(14%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA- 69 + LRDG Q+ K+ + K L+Q + +E+A S+ + V++++E Sbjct 34 MSTDLRDGNQSLFEPMDAQRKMRMFKTLVQ-IGFKEIEVAFPSASQTDFNFVRELIEGGH 92 Query 70 ------------ATEQLTER-IEILGFVDGNKTVDWIKDSGA----KVLNLLTKGSLHHL 112 A + L ER E L V + + + ++ A K++ L K + L Sbjct 93 IPDDVTIEVLTQARDDLIERTFESLRGVP--RAIVHLYNATAPEFRKIVFNLEKSGVKEL 150 Query 113 EKQLGKTPKEF---FTDVSFVIEYA--IKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLS 167 + +T K + F +Y+ + SG +I E D V + E + Sbjct 151 AQNAARTMKRIAATMPETQFTFQYSPEVFSGTEIEFAKE--------VCDAVFDIWEP-T 201 Query 168 KEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIR 224 EH + LP T+ + +P + + + +++ + H HND +VA + A+ Sbjct 202 PEHKAIVNLPATVEMSTPNIYADQIEWMHRNLKRRDSLVISVHPHNDRGTAVAAAELAVM 261 Query 225 AGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNSKTNINEIAITEASRLVEVFSG 280 AG + + G GER GN L L ++ D +NINE+A R E + Sbjct 262 AGADRIEGCLFGNGERTGNVDLVTLALNLYTQGVDPGLDFSNINEVA-----RTAEECTQ 316 Query 281 KRISANRPIVGEDVFTQTAGVHADGDKKGNLYANP 315 I P VG+ VFT +G H D KKG P Sbjct 317 LPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKP 351 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Paraburkholderia phytofirmans PsJN] Sequence ID: B2SXZ9.1 Length: 572 Range 1: 34 to 351 Score:60.8 bits(146), Expect:1e-08, Method:Compositional matrix adjust., Identities:81/335(24%), Positives:134/335(40%), Gaps:47/335(14%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA- 69 + LRDG Q+ K+ + K L+Q + +E+A S+ + V++++E Sbjct 34 MSTDLRDGNQSLFEPMDAQRKMRMFKTLVQ-IGFKEIEVAFPSASQTDFNFVRELIEGGH 92 Query 70 ------------ATEQLTER-IEILGFVDGNKTVDWIKDSGA----KVLNLLTKGSLHHL 112 A + L ER E L V + + + ++ A K++ L K + L Sbjct 93 IPDDVTIEVLTQARDDLIERTFESLRGVP--RAIVHLYNATAPEFRKIVFNLEKSGVKEL 150 Query 113 EKQLGKTPKEF---FTDVSFVIEYA--IKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLS 167 + +T K + F +Y+ + SG +I E F V + Sbjct 151 AQNAARTMKRIAATMPETQFTFQYSPEVFSGTEIEFAKEVCDAVFD---------VWQPT 201 Query 168 KEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIR 224 EH + LP T+ + +P + + + + + + H HND +VA + A+ Sbjct 202 PEHKAIVNLPATVEMSTPNIYADQIEWMHRNLARRDSLIISVHPHNDRGTAVAAAELAVM 261 Query 225 AGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNSKTNINEIAITEASRLVEVFSG 280 AG + + G GER GN L L ++ D +NINE+A R E + Sbjct 262 AGADRIEGCLFGNGERTGNVDLVTLALNLYTQGVDPGLDFSNINEVA-----RTAEECTQ 316 Query 281 KRISANRPIVGEDVFTQTAGVHADGDKKGNLYANP 315 I P VG+ VFT +G H D KKG P Sbjct 317 LPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKP 351 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Azotobacter vinelandii DJ] Sequence ID: C1DN55.1 Length: 350 Range 1: 168 to 250 Score:59.7 bits(143), Expect:2e-08, Method:Compositional matrix adjust., Identities:29/83(35%), Positives:46/83(55%), Gaps:1/83(1%) Query 172 ERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 + +++ D+ G + PE+ V +L + P+ FHGH++ + +ANS+ AI AG + Sbjct 168 QTVYVTDSAGYMLPEDVKARVGALREVLAPETGIGFHGHHNLGMGIANSIAAIEAGASRI 227 Query 231 HASINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE Sbjct 228 DGSVAGLGAGAGNTPLEVFAAVC 250 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Mycobacteroides abscessus ATCC 19977] Sequence ID: B1MH40.1 Length: 359 Range 1: 208 to 281 Score:58.9 bits(141), Expect:4e-08, Method:Compositional matrix adjust., Identities:32/75(43%), Positives:43/75(57%), Gaps:1/75(1%) Query 201 DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSK 260 D FHGH + L VANS++A+RAG K + S G AGN P+EAL+ + DK K Sbjct 208 DAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSTRRFGAGAGNAPVEALI-GVFDKIGVK 266 Query 261 TNINEIAITEASRLV 275 T I+ I +A+ V Sbjct 267 TGIDFFDIADAAEEV 281 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Streptosporangium roseum DSM 43021] Sequence ID: D2ATJ4.1 Length: 579 Range 1: 36 to 348 Score:59.3 bits(142), Expect:5e-08, Method:Compositional matrix adjust., Identities:77/329(23%), Positives:129/329(39%), Gaps:46/329(13%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAA 70 L LRDG Q+ S KL + + LL + +E+ S+ + + ++ ++E Sbjct 36 LSTDLRDGNQSLATPMSPDRKLAMFE-LLVSMGYKEIEVGFPVASQDDFDFLRVLIE--- 91 Query 71 TEQLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF-- 123 E++ E + I V +TV+ ++ + ++L S G + E Sbjct 92 QERIPEDVRISVLVQARDELIRRTVESLEGAPRATIHLYNATSPLFRRVVFGMSRNECKD 151 Query 124 --FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF------ 175 +++YA K+ L D GF+ SP+ S E E + Sbjct 152 LAVQGTRLMMKYAEKT-------LGDCDLGFQYSPELFSDTELDFSLEVCEAVMDVWQPE 204 Query 176 --------LPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIR 224 P T+ P ++ L + + + H HND +VA++ A+ Sbjct 205 PGRGIILNFPTTVERSLPNVFADQIEWLSRNLSRREHVCLSIHPHNDRGTAVASAELALL 264 Query 225 AGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNSKTNINEIAITEASRLVEVFSG 280 AG + + + G GERAGN L L + D ++INEI R VE +G Sbjct 265 AGAERIEGCLFGNGERAGNVCLVTLGLNMFTHGVDPGIDFSDINEI-----RRTVERCNG 319 Query 281 KRISANRPIVGEDVFTQTAGVHADGDKKG 309 + P G+ V+T +G H D KKG Sbjct 320 LAVHPRHPYGGDLVYTSFSGSHQDAIKKG 348 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Herbaspirillum seropedicae SmR1] Sequence ID: D8J0Q1.1 Length: 575 Range 1: 208 to 356 Score:58.9 bits(141), Expect:5e-08, Method:Compositional matrix adjust., Identities:42/150(28%), Positives:70/150(46%), Gaps:4/150(2%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I LP T+ V +P + + +D +++ + H HND +VA + QA+ AG + + Sbjct 208 INLPTTVEVSTPNVFADQIEWMDRRLERREHLILSVHPHNDRGTAVACAEQAMLAGAQRV 267 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 + G GER+GN + L ++ + + ++ I +R+ E + I P V Sbjct 268 EGCLFGNGERSGNVDVVTLALNLYTQGIAP-GLDFSDIAALARVAEECTALPIHPRHPYV 326 Query 291 GEDVFTQTAGVHADGDKKGNLYANPILPER 320 G+ VFT +G H D KG P P R Sbjct 327 GDLVFTAFSGSHQDAIAKGFAAQRPDAPWR 356 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Clostridium acetobutylicum ATCC 824] Sequence ID: Q97MC5.1 Length: 558 Range 1: 31 to 344 Score:58.9 bits(141), Expect:6e-08, Method:Compositional matrix adjust., Identities:82/332(25%), Positives:133/332(40%), Gaps:51/332(15%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAA 70 V LRDG Q + EK+ + K L+ + +EI S+ E E +K++E Sbjct 31 CSVDLRDGNQALPKPMNVDEKIKMFKMLVD-IGFKEIEIGFPSASETEYEFTRKLIE--- 86 Query 71 TEQLTERIEILGFVDG-----NKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFT 125 + + E + I KT + +K G K + S L++++ F Sbjct 87 DKLIPEDVTIQVLTQAREHLVKKTFEALK--GVKTAIVHVYNSTSELQRRVV-----FKK 139 Query 126 DVSFVIEYAIKSGLKINVYLE--DWSNG---FRNSP--------DYVKSLVEHL------ 166 D V AIK + Y E ++S F SP DY + E + Sbjct 140 DKDEVKSLAIKGAQMVKKYSEYTEYSESKFVFEYSPESFTGTELDYALEVCEAVLNVWKP 199 Query 167 SKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY---PDIHFEFHGHNDYDLSVANSLQAI 223 SKE+ I LP T+ + +P ++ +K + H HND A+S I Sbjct 200 SKENKAIINLPSTVEMATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGI 259 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNSKTNINEI--AITEASRLVEV 277 AG + ++ G GER GN + + ++ D +N+N+I A E +++V Sbjct 260 LAGADRVEGTLFGNGERTGNLDIMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMV-- 317 Query 278 FSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 + P G+ VFT +G H D +KG Sbjct 318 -----VHERHPYAGKLVFTAFSGSHQDAIRKG 344 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Burkholderia thailandensis E264] Sequence ID: Q2T7S9.1 Length: 347 Range 1: 157 to 255 Score:58.2 bits(139), Expect:7e-08, Method:Compositional matrix adjust., Identities:35/100(35%), Positives:52/100(52%), Gaps:5/100(5%) Query 172 ERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLH 231 + + L D+ G +P V+ L+ DI FH HN+ L+VANSL A+ AG + + Sbjct 157 QAVVLMDSAGYSTPSLVRAKVERLVDGL-DIDVGFHAHNNLGLAVANSLVALEAGARIVD 215 Query 232 ASINGLGERAGNTPLEALVTTI----HDKSNSKTNINEIA 267 A + G G AGNT LE LV + HD + ++ +A Sbjct 216 ACVKGFGAGAGNTQLETLVAAMEREGHDTRTTFEHVMALA 255 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Pseudomonas sp.] Sequence ID: Q9KWS0.1 Length: 343 Range 1: 1 to 319 Score:58.2 bits(139), Expect:7e-08, Method:Compositional matrix adjust., Identities:86/346(25%), Positives:145/346(41%), Gaps:48/346(13%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M ++ I DVTLRDG ++ + IA+ L + VD +E+A KG Sbjct 1 MIDQAKKIYISDVTLRDGMHAIRHRYTLNHVSQIAR-ALDEAGVDSIEVAHGDGLKGSSF 59 Query 61 T----VQKIMEW--AATEQLTE-RIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSLH 110 +EW AA E + + +I L + G TV ++ D+GA+V+ + T + Sbjct 60 NYGFGAYSDLEWISAAAEAVKQAKIATL-LLPGIGTVHDLREAYDAGARVVRVATHCTEA 118 Query 111 HLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH 170 + +Q IEYA G+ +L +P + + + Sbjct 119 DVSRQH--------------IEYARGLGMDTVGFL---MMSHMQTPVGLAQQAKLMENYG 161 Query 171 IERIFLPDTLGVLSP---EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGV 227 + I++ D+ G ++ E F+ + ++ P H H++ L VANSL A+ G Sbjct 162 AQCIYVVDSGGAMNMWDIAERFKALKDVLD--PATQTGMHAHHNLSLGVANSLVALENGC 219 Query 228 KGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISAN 286 + AS+ G+G AGN PLE + N ++ ++ I A +V + + + Sbjct 220 DRVDASLTGMGAGAGNAPLEVFIAAAERMGLNHGCDVKKL-INAAEDIVRPLQERPVRVD 278 Query 287 RPIVGEDVFTQTAGVHAD-------GDKKGNLYANPILPERFGRKR 325 R E + AGV++ KK NL A IL E G++R Sbjct 279 R----ETLALGYAGVYSSFLRHAETAAKKYNLSAFDILVE-LGKRR 319 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Azoarcus olearius] Sequence ID: A1K6L9.1 Length: 347 Range 1: 166 to 248 Score:58.2 bits(139), Expect:7e-08, Method:Compositional matrix adjust., Identities:28/83(34%), Positives:45/83(54%), Gaps:1/83(1%) Query 172 ERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 + +++ D+ G + P + V +L + P+ FHGH++ + +ANS+ AI AG + Sbjct 166 QTVYVTDSAGYMLPADVTARVRALREVLNPETEIGFHGHHNLGMGIANSIAAIEAGATRI 225 Query 231 HASINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE Sbjct 226 DGSVAGLGAGAGNTPLEVFAAVC 248 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Metapseudomonas furukawaii] Sequence ID: Q4F8H9.1 Length: 347 Range 1: 166 to 246 Score:57.8 bits(138), Expect:9e-08, Method:Compositional matrix adjust., Identities:29/81(36%), Positives:43/81(53%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I+ D+ G + P+E + + L + P FHGH++ +++ANSL R G + Sbjct 166 IYCTDSAGYMLPDEVSEKIGLLRAELNPATEIGFHGHHNMGMAIANSLAGHRGGASRIDG 225 Query 233 SINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE V Sbjct 226 SVAGLGAGAGNTPLEVFVAVC 246 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Magnetococcus marinus MC-1] Sequence ID: A0LBW3.1 Length: 559 Range 1: 211 to 364 Score:58.2 bits(139), Expect:9e-08, Method:Compositional matrix adjust., Identities:44/156(28%), Positives:72/156(46%), Gaps:15/156(9%) Query 176 LPDTLGVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P ++ ++ D I H HND +VA + A+ AG + Sbjct 211 LPATVEMSTPNIYADQIEWMLSHLSDPQSIIISLHAHNDRGTAVAATELAMLAGAGRVEG 270 Query 233 SINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 ++ G GER GNT + A+ +H + ++ N +E+ A+ E +G + +P G Sbjct 271 TLFGNGERTGNTDVVAVAMNLHSQGIDAGLNFSEMPRIIATS--EACTGMSVPPRQPYAG 328 Query 292 EDVFTQTAGVHADGDKKG---------NLYANPILP 318 E VFT +G H D +KG +A P LP Sbjct 329 ELVFTAFSGSHQDAIRKGLHLHKQEQAQQWAVPYLP 364 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Methylibium petroleiphilum PM1] Sequence ID: A2SL35.1 Length: 358 Range 1: 133 to 263 Score:57.4 bits(137), Expect:1e-07, Method:Compositional matrix adjust., Identities:37/135(27%), Positives:65/135(48%), Gaps:5/135(3%) Query 131 IEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQ 190 I YA K G+ +L N P+ + + + + +++ D+ G + P + Sbjct 133 IAYARKLGMDTVGFL---MMAHLNDPEGLAKQGKLMEDYGAQTVYVTDSAGYMLPADVRA 189 Query 191 GVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEAL 249 V +L P+ FHGH++ + +ANS+ AI G + S+ GLG AGNTPLE Sbjct 190 RVAALRAVLKPETEIGFHGHHNLGMGIANSIAAIEEGASRIDGSVAGLGAGAGNTPLEVF 249 Query 250 VTTIHDKSNSKTNIN 264 + + D+ +T ++ Sbjct 250 L-AVCDRMGIETGVD 263 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Parvibaculum lavamentivorans DS-1] Sequence ID: A7HP03.1 Length: 563 Range 1: 185 to 361 Score:57.0 bits(136), Expect:2e-07, Method:Compositional matrix adjust., Identities:52/182(29%), Positives:79/182(43%), Gaps:25/182(13%) Query 157 DYVKSLVEHLSK------EHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFH 207 D+ K +V+ +++ E I LP T+ + +P + + + +++ I H Sbjct 185 DFAKEVVDAVTEIWEAGPERKVVINLPATVEMATPNIYADQIEWMHRNLERRDGIILSVH 244 Query 208 GHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNSKTNI 263 HND +VA + AI AG + + G GER GN L L ++ D I Sbjct 245 PHNDRGTAVAAAELAIMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGIDPGLDFAQI 304 Query 264 NEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKK-------GNLYANPI 316 NEIA R E + I P VG+ VFT +G H D KK G+++ P Sbjct 305 NEIA-----RTAEYCTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGLAAYKAGDIWQVPY 359 Query 317 LP 318 LP Sbjct 360 LP 361 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Thermomicrobium roseum DSM 5159] Sequence ID: B9L2J0.1 Length: 356 Range 1: 2 to 288 Score:56.2 bits(134), Expect:3e-07, Method:Compositional matrix adjust., Identities:67/314(21%), Positives:129/314(41%), Gaps:40/314(12%) Query 3 KVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEI------ASARVSK 56 K T + D TLRDG F T E++ L + V +E+ A + + Sbjct 2 KTLTPPRVTDTTLRDGSHAMRHQF-TREQVRAIVAALDEAGVPVIEVTHGDGLAGSSIQY 60 Query 57 G-----ELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHH 111 G ELE +++ + A ++ + L + + + + G KV+ + T+ + Sbjct 61 GFSATSELELIEEAAKTAKRAKIAALL--LPGIGTRRELSAAIERGIKVVRIATQCTEAD 118 Query 112 LEKQLGKTPKEF-FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH 170 + +Q KE V F++ ++ P+++ + Sbjct 119 ISEQHFGMAKEMGLETVGFLMMAHMRP------------------PEFLAEQAALMESYG 160 Query 171 IERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 + +++ D+ G + P++ + V +L ++ I FH HN+ L++ N+L AI G + Sbjct 161 ADCVYIVDSAGAMLPDDVRRRVAALKERL-SIQVGFHAHNNLGLAIGNTLAAIEEGADQV 219 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 + GLG AGN P E L+ + DK ++ + +A+ + I +PI Sbjct 220 DGCLRGLGAGAGNAPTE-LIAAVLDKLGINPGLDVFKLMDAAEYIVA----PIMPYQPIP 274 Query 291 GEDVFT-QTAGVHA 303 D T AGV++ Sbjct 275 DRDAITIGYAGVYS 288 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Marinomonas sp. MWYL1] Sequence ID: A6VSA9.1 Length: 558 Range 1: 38 to 495 Score:56.6 bits(135), Expect:3e-07, Method:Compositional matrix adjust., Identities:110/481(23%), Positives:185/481(38%), Gaps:76/481(15%) Query 15 LRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQL 74 LRDG Q +K+ K L++ +E+A S+ + + V+ ++E + + Sbjct 38 LRDGNQALANPMDHVKKMAFFKHLIE-CGFKEIEVAFPAASQTDFDFVRLLIE---GKHI 93 Query 75 TERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKE--FFTDVSFVIE 132 + + I V VD I+ + ++ K ++ H+ +E F D +E Sbjct 94 PDDVTIQ--VMTQSRVDLIERTIQSLVG--AKKAIVHIYNATAPVFREIVFCQDKPATLE 149 Query 133 YAIKSGLKINVYLED-----WSNGFR------NSPDYVKSLVEHLSK---EHIER---IF 175 A++ I E W+ + PD+ + E +K +ER + Sbjct 150 LAVQGVKHIRQLCEQYPDTQWTLQYSPETFCFTEPDFALEVCEAAAKTWQPSLERPMILN 209 Query 176 LPDTLGVLSPEETFQGVDSLIQKYP---DIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V +P ++ I + +I H HND VA + AI AG + + Sbjct 210 LPTTVEVNTPNVFADQIEHFITSFSSLENITISVHPHNDRGTGVATAEMAILAGAQRVEG 269 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L ++ + N++ + LVE + + P G Sbjct 270 CLFGNGERTGNVDLVTLAMNLYSQ-GVYPNLDFSDMRRTVELVEECNELPVHPRHPYAGA 328 Query 293 DVFTQTAGVHADGDKKG---------NLYANPILP----------ERFGRKRSYALGKLA 333 FT +G H D KKG ++ P LP E R S + GK Sbjct 329 LAFTAFSGSHQDAIKKGFASQKSTSSMIWQIPYLPLDPKDIGCTYEEVIRVNSQS-GKSG 387 Query 334 GKASISENVKQLGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADV---------- 383 + EN G+ L + ++V DQ T ++P +ADV Sbjct 388 AAWLLQEN---HGLFLPRKLQIDFSKKVKNHTDQ----TGHEMP--LADVWRLFRESYRL 438 Query 384 --SGRTGEKVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKIT 441 + K++ +S HS G++ + L YQ K + + EG G A ++AL K Sbjct 439 NPDDKGQMKLMDYRS---HSSNGLQ-EIRATLRYQEKTWQLVGEGKGLLSAMLDALRKRF 494 Query 442 N 442 N Sbjct 495 N 495 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Pseudomonas putida W619] Sequence ID: B1J6Y1.1 Length: 339 Range 1: 1 to 244 Score:54.7 bits(130), Expect:7e-07, Method:Compositional matrix adjust., Identities:68/265(26%), Positives:107/265(40%), Gaps:34/265(12%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M ++ I DVTLRDG +S + IA+ L Q VD +E+A +G Sbjct 1 MINTNKKIHISDVTLRDGMHAVRHRYSLEQVAGIAQALDQA-GVDSIEVAHGDGLQGSSF 59 Query 61 T----VQKIMEWAATEQLT---ERIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSLH 110 EW A RI L + G TV +K D+GA+++ + T H Sbjct 60 NYGFGAHTDFEWIAAVAAVVQRARIATL-LLPGIGTVHDLKAAYDAGARIVRVAT----H 114 Query 111 HLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH 170 E + + IEYA G+ +L +P + + + Sbjct 115 CTEADVSRQH----------IEYARSLGMDTVGFL---MMSHMQTPAGLARQGKLMESYG 161 Query 171 IERIFLPDTLGVLSP---EETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGV 227 + I++ D+ G ++ E F+ + ++ P H H++ L VANSL A+ G Sbjct 162 AQCIYVVDSGGAMNMWDIAERFKAMKDVLD--PATQTGMHAHHNLSLGVANSLVALEHGC 219 Query 228 KGLHASINGLGERAGNTPLEALVTT 252 + AS+ G+G AGN PLE Sbjct 220 DRVDASLTGMGAGAGNAPLEVFAAA 244 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Nocardia farcinica IFM 10152] Sequence ID: Q5YVA5.1 Length: 580 Range 1: 239 to 374 Score:55.1 bits(131), Expect:1e-06, Method:Compositional matrix adjust., Identities:40/137(29%), Positives:61/137(44%), Gaps:4/137(2%) Query 176 LPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V +P ++ + + + + H HND +A + A+ AG + + Sbjct 239 LPATVEVATPNVYADQIEYMHRNLARRDSVILSVHPHNDRGTGIACAELAVLAGAQRVEG 298 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN + L +H + I+ I E R VE + I A P VG+ Sbjct 299 CVFGNGERTGNVDIATLALNLHAQGVDPM-IDFSDIDEIRRTVEYCNRVEIHARHPYVGD 357 Query 293 DVFTQTAGVHADGDKKG 309 V T +G H D KKG Sbjct 358 LVHTAFSGTHQDAIKKG 374 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Rhodococcus jostii RHA1] Sequence ID: Q0SJD5.1 Length: 346 Range 1: 15 to 270 Score:53.9 bits(128), Expect:1e-06, Method:Compositional matrix adjust., Identities:74/281(26%), Positives:113/281(40%), Gaps:41/281(14%) Query 8 LEILDVTLRDG-EQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV---- 62 L I DVTLRDG TR T E + + L VD +E++ G T Sbjct 15 LYIQDVTLRDGMHATR--HHITPENVAVIAGALDSAGVDAIEVSHGDGLAGHSLTYGPGS 72 Query 63 QKIMEW---AATEQLTERIEILGFVDGNKTVDWIKDS---GAKVLNLLTKGSLHHLEKQL 116 EW AA ++ L + G TV +K + G + + + T + + Q Sbjct 73 NTDWEWIEAAAAVVHCAKLTTL-LLPGIGTVAELKRARALGVQSVRVATHCTEADVSAQH 131 Query 117 GKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFL 176 T +E DVS G + +L + P + + + +++ Sbjct 132 ISTARELGMDVS---------GFLMMSHLAE--------PQQLAEQAKLMESYGAHCVYV 174 Query 177 PDTLGVLSPEETFQGVDSLIQKYPDI-----HFEFHGHNDYDLSVANSLQAIRAGVKGLH 231 D+ G L T GV ++ Y DI H H + LSVANS+ A+ GV + Sbjct 175 TDSGGRL----TMDGVRQRVRAYRDILDAETQIGIHAHQNLSLSVANSVVAVEEGVTRVD 230 Query 232 ASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 AS+ G G AGN P+E V + D K N + A+ +A+ Sbjct 231 ASLAGHGAGAGNCPIEPFV-AVADLHGWKHNCDLFALQDAA 270 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Bacillus pumilus SAFR-032] Sequence ID: A8FAK7.1 Length: 553 Range 1: 36 to 347 Score:54.3 bits(129), Expect:2e-06, Method:Compositional matrix adjust., Identities:73/321(23%), Positives:131/321(40%), Gaps:30/321(9%) Query 13 VTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATE 72 V LRDG Q + + EKL + + L++ + +EIA S E ++ +++ Sbjct 36 VDLRDGNQALPIPMNLEEKLEMFQLLVE-IGFKEIEIAFPAASDTEFRLLRTLID---HH 91 Query 73 QLTERIEILGFVDGN-----KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP---KEFF 124 + + + I+ +T + IK +++L S + KT K+ Sbjct 92 MIPDDVTIMVITQAREHIIRRTFEAIKGVPKAIVHLYNSTSEAQRRQVFKKTKDEVKQMA 151 Query 125 TDVSFVIEYAIKSGLKINVYLEDWSNGFRNSP-DYVKSLVEHL------SKEHIERIFLP 177 D + +++ + + ++Y + F + DY + + + H I +P Sbjct 152 MDGAILVK-ELAEKTESDIYFQYSPESFPGTEVDYALDICNSVLDIWKPTPNHKAIINIP 210 Query 178 DTLGVLSPEETFQGVDSLIQK---YPD-IHFEFHGHNDYDLSVANSLQAIRAGVKGLHAS 233 T+ P F I K Y D + H HND V+++ + AG + + + Sbjct 211 TTVEYSMPH-IFASQIEYIHKNLSYRDSVTLSVHPHNDRGSGVSDAEFGVLAGAERVEGT 269 Query 234 INGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASR-LVEVFSGKRISANRPIVG 291 + G+GER GN L L ++ + + K N N + EA R E + + +P G Sbjct 270 LFGIGERTGNVDLITLAMNMYSQGYDPKLNFNNL---EAIRKQYEKLTNITVHERQPYSG 326 Query 292 EDVFTQTAGVHADGDKKGNLY 312 E VFT +G H D KG Y Sbjct 327 EMVFTAFSGSHQDAISKGMKY 347 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Streptomyces avermitilis MA-4680 = NBRC 14893] Sequence ID: Q82BV3.1 Length: 573 Range 1: 40 to 354 Score:53.9 bits(128), Expect:2e-06, Method:Compositional matrix adjust., Identities:77/331(23%), Positives:126/331(38%), Gaps:48/331(14%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIME--- 67 L LRDG Q S + K + LL K+ +E+ + + + V+ I+E Sbjct 40 LSTDLRDGNQALIDPMSPARKREMFD-LLVKMGYKEIEVGFPASGQTDFDFVRSIIEDET 98 Query 68 -----------WAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLN-LLTKGSLHHLEKQ 115 A E L ER + V + + ++ A V ++ +GS + KQ Sbjct 99 AIPDDVTISVLTQAREDLIERT-VESLVGAKRATVHLYNATAPVFRRVVFRGSKDQI-KQ 156 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 + V+EYA K + E + G++ SP+ + E E + Sbjct 157 IA------VDGTRLVVEYAEK------LLDERTTFGYQYSPEIFTDTELDFALEVCEAVM 204 Query 176 --------------LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVAN 218 LP T+ +P + F+ + + + + H HND +VA Sbjct 205 DVWQPGPDREIILNLPATVERSTPSTHADRFEWMSRNLSRREYVCLSVHPHNDRGTAVAA 264 Query 219 SLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVF 278 + A+ AG + + G GER GN L L + + I+ I E R E Sbjct 265 AELALMAGADRIEGCLFGQGERTGNVDLVTLGMNLFSQ-GVDPQIDFSNIDEVRRTAEYC 323 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 + + A P VG+ V+T +G H D KKG Sbjct 324 NQMEVHARHPYVGDLVYTSFSGSHQDAIKKG 354 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Azoarcus olearius] Sequence ID: A1KBD3.1 Length: 572 Range 1: 216 to 359 Score:53.5 bits(127), Expect:2e-06, Method:Compositional matrix adjust., Identities:41/145(28%), Positives:64/145(44%), Gaps:4/145(2%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I LP T+ + +P + + + + + + H HND +VA + A+ AG + Sbjct 216 INLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADRV 275 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 + G GER GN L L ++ + ++ I E +R VE + I P V Sbjct 276 EGCLFGNGERTGNVDLVTLALNLYSQ-GVHPGLDFSRINEVARTVEHCTQLPIHPRHPYV 334 Query 291 GEDVFTQTAGVHADGDKKGNLYANP 315 G+ VFT +G H D KKG P Sbjct 335 GDLVFTAFSGSHQDAIKKGFAVQQP 359 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Ralstonia pickettii 12J] Sequence ID: B2UJY9.1 Length: 570 Range 1: 25 to 354 Score:53.5 bits(127), Expect:3e-06, Method:Compositional matrix adjust., Identities:78/345(23%), Positives:137/345(39%), Gaps:44/345(12%) Query 3 KVETRLEI-LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET 61 K TR I + LRDG Q + K+ + K L+Q + +E A S+ + + Sbjct 25 KTITRAPIWMSTDLRDGNQALFEPMNAERKMRMFKMLVQ-IGFKEIEAAFPAASQTDFDF 83 Query 62 VQKIMEWA------ATEQLTERIEIL------GFVDGNKTVDWIKDSGAKVLNLLT---- 105 V++++E A E LT+ E L + + + ++ A V Sbjct 84 VRELIEGGHIPDGVAIEVLTQAREDLIRRTMESLRGAKRAIIHVYNATAPVFRRTVFNTD 143 Query 106 KGSLHHLEKQLGKTPKEF---FTDVSFVIEYA--IKSGLKINVYLEDWSNGFRNSPDYVK 160 + + + Q K +E + + +Y+ + SG +++ LE + Sbjct 144 REGVKRIAVQSAKLIREIAQTMPETQWTYQYSPEVFSGTELDFALEVCN---------AV 194 Query 161 SLVEHLSKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVA 217 + V + EH LP T+ + +P + + + + + I H HND +VA Sbjct 195 TEVWEPTPEHKIIFNLPATVEMATPNIYADQIEWMHRNLARRDSIILSVHPHNDRGTAVA 254 Query 218 NSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNSKTNINEIAITEASR 273 + A+ AG + + G GER GN + L ++ D ++IN++A R Sbjct 255 AAELAVMAGADRVEGCLFGNGERTGNVDIVTLALNLYSQGVDPELDFSHINDVA-----R 309 Query 274 LVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILP 318 E + + P VG+ VFT +G H D KKG P P Sbjct 310 TCEDCTQLPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKPDAP 354 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 5; Short=HOA 5; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 5; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 5 [Rhodococcus opacus B4] Sequence ID: C1AYB4.1 Length: 352 Range 1: 148 to 264 Score:52.8 bits(125), Expect:3e-06, Method:Compositional matrix adjust., Identities:33/118(28%), Positives:57/118(48%), Gaps:2/118(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L V +L+ + D FHGH + L Sbjct 148 PEVLAKQARIMADAGCQCVYVVDSAGALILNAVSDRVSALVAELGDDAQVGFHGHENLGL 207 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 VANS+ A+ AG + S G AGNTP+EA + +K +T I+ + I +A+ Sbjct 208 GVANSVLAVEAGALQIDGSTRRFGAGAGNTPVEAF-AAVTEKLGIRTGIDTLKIIDAA 264 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 4; Short=HOA 4; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 4; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 4 [Rhodococcus jostii RHA1] Sequence ID: Q0S4F8.1 Length: 352 Range 1: 148 to 264 Score:52.8 bits(125), Expect:3e-06, Method:Compositional matrix adjust., Identities:33/118(28%), Positives:57/118(48%), Gaps:2/118(1%) Query 156 PDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDL 214 P+ + ++ + +++ D+ G L V +L+ + D FHGH + L Sbjct 148 PEVLAKQARIMADAGCQCVYVVDSAGALILNAVSDRVSALVAELGDDAQVGFHGHENLGL 207 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 VANS+ A+ AG + S G AGNTP+EA + +K +T I+ + I +A+ Sbjct 208 GVANSVLAVEAGALQIDGSTRRFGAGAGNTPVEAF-AAVTEKLGIRTGIDTLKIIDAA 264 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Renibacterium salmoninarum ATCC 33209] Sequence ID: A9WML8.1 Length: 582 Range 1: 35 to 354 Score:53.1 bits(126), Expect:4e-06, Method:Compositional matrix adjust., Identities:77/336(23%), Positives:132/336(39%), Gaps:45/336(13%) Query 3 KVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV 62 ++ T V LRDG Q S + KL + + L+ K+ +E+ S+ + + V Sbjct 35 RITTAPRWCAVDLRDGNQALIDPMSPARKLKMFELLV-KMGYKEIEVGFPSASQTDFDFV 93 Query 63 QKIMEWA-------------ATEQLTERIEILGFVDGNKTVDWIKDSGA----------- 98 +++++ A E L ER V + + + +S + Sbjct 94 RQLIQGGHIPEDVTIQVLTQAREHLIERT-YESLVGAKQAIVHLYNSTSVLQRRVVFNED 152 Query 99 --KVLNLLTKGSLHHLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSP 156 ++ L T+G+L L K +E TD EY+ +S + D++ N+ Sbjct 153 QDGIMALATQGAL------LCKKYQETLTDTKITYEYSPESFTGTEL---DYAVRVCNA- 202 Query 157 DYVKSLVEHLSKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYD 213 V + E + + + LP T+ +++P ++ + + + I H HND Sbjct 203 --VADIFEASADNQV-IVNLPATVEMITPNVYADSIEWMSHNLHPREGIILSLHPHNDRG 259 Query 214 LSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASR 273 VA + AG + + G GERAGN L L + + I+ I E R Sbjct 260 TGVAAAELGYLAGADRIEGCLFGNGERAGNVDLVTLGLNMFSQGVDPM-IDFSDIDEIRR 318 Query 274 LVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 VE + P G+ VFT +G H D KKG Sbjct 319 TVEYCNQLPAPERMPYGGDLVFTAFSGSHQDAIKKG 354 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Pseudoalteromonas translucida TAC125] Sequence ID: Q3IEQ9.1 Length: 344 Range 1: 165 to 245 Score:52.0 bits(123), Expect:6e-06, Method:Compositional matrix adjust., Identities:27/81(33%), Positives:42/81(51%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I+ D+ G + P++ + L + + FHGH++ +S+ NSL AI G + Sbjct 165 IYCTDSAGYMLPDDVSTRIALLRSELNSETEIGFHGHHNLGMSIPNSLAAIEMGANRIDG 224 Query 233 SINGLGERAGNTPLEALVTTI 253 S+ GLG AGNTPLE + Sbjct 225 SVAGLGAGAGNTPLEVFTAVL 245 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 5; Short=HOA 5; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 5; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 5 [Rhodococcus jostii RHA1] Sequence ID: Q0S006.1 Length: 342 Range 1: 3 to 260 Score:51.6 bits(122), Expect:7e-06, Method:Compositional matrix adjust., Identities:73/282(26%), Positives:118/282(41%), Gaps:39/282(13%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASAR-VSKGELET--- 61 TRL I DVTLRDG + + I L VD +E+A ++ G L Sbjct 3 TRLFIQDVTLRDGMHAVRHRITPDDVGKIVAAL-DAAGVDGIEVAHGDGLAGGSLNYGPG 61 Query 62 VQKIMEW--AATEQLTE-RIEILGFVDGNKTVDWIKDS---GAKVLNLLTKGSLHHLEKQ 115 EW AA + LT R+ L + G T+ ++ + G + + + T + + Q Sbjct 62 SNTDWEWIEAAADNLTHARLTTL-LLPGIGTIAELEHAYVLGVRSIRIATHCTEADVSAQ 120 Query 116 LGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF 175 +E DVS G + ++ SP + + + + ++ Sbjct 121 HIGKARELGMDVS---------GFLMMSHMA--------SPAELAAQAKLMESYGAHCVY 163 Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIHFE-----FHGHNDYDLSVANSLQAIRAGVKGL 230 + D+ G L T GV ++ Y D+ E H H + LSVANS+ A+ GV + Sbjct 164 VTDSGGRL----TMDGVRERVRAYRDVLDEATEIGIHAHENLSLSVANSVVAVEEGVTRV 219 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 AS+ G G AGN P+E + + D K N + A+ +A+ Sbjct 220 DASLAGHGAGAGNCPIEPFI-AVADLQGWKHNSDLFALQDAA 260 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Nocardioides sp. JS614] Sequence ID: A1SIM3.1 Length: 342 Range 1: 1 to 243 Score:51.6 bits(122), Expect:8e-06, Method:Compositional matrix adjust., Identities:69/266(26%), Positives:112/266(42%), Gaps:38/266(14%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEI------ASARV 54 M + T + + DVTLRDG + E IA L VD +EI A + + Sbjct 1 MNETRTTVFVQDVTLRDGMHAIRHQLAPGEVAQIAAAL-DVAGVDAIEISHGDGLAGSSL 59 Query 55 SKGE-LETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSLH 110 + G T + +E AA R+ L + G TVD ++ D G + + + T + Sbjct 60 NYGPGSHTDWEWIEAAAANIQRARLTTL-LLPGIGTVDELRKAHDLGVRSVRVATHCTEA 118 Query 111 HLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH 170 + Q +T ++ DV+ G + ++ ++ ++S H Sbjct 119 DVSAQHIETARDLGMDVA---------GFLMMSHMAA-ASELAAQAALMESYGAHC---- 164 Query 171 IERIFLPDTLGVLSPEETFQGVDSLIQKYPDI-----HFEFHGHNDYDLSVANSLQAIRA 225 +++ D+ G L T V ++ Y D+ H H + LSVANS+ A+ A Sbjct 165 ---VYVTDSGGRL----TMDAVRDRVRAYRDVLDATTEIGIHAHENLSLSVANSVVAVEA 217 Query 226 GVKGLHASINGLGERAGNTPLEALVT 251 GV + AS+ G G AGN P+EA V Sbjct 218 GVTRVDASLAGQGAGAGNCPIEAFVA 243 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Xanthobacter versatilis] Sequence ID: A7IDU6.1 Length: 344 Range 1: 8 to 249 Score:51.2 bits(121), Expect:1e-05, Method:Compositional matrix adjust., Identities:63/260(24%), Positives:109/260(41%), Gaps:28/260(10%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET----V 62 +L I DVTLRDG + + IA+ L + VD +EI+ G Sbjct 8 KLYIQDVTLRDGMHALRHQYDLAATRAIARAL-DRARVDAIEISHGDGLTGSTFNYGFGA 66 Query 63 QKIMEW--AATEQLTERIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSLHHLEKQLG 117 EW A E+ + + + + G TV +K ++GA+ + + T + + +Q Sbjct 67 HDDAEWIAAVAEECSHAVVTVLLIPGIGTVHDLKHAYEAGARSVRVCTHCTEADVSRQHI 126 Query 118 KTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 + +E D + + A P+ + + E +++ Sbjct 127 EAARELGMDTATFLMMA-----------------HMIPPEALAEQARLMESYGAECVYVT 169 Query 178 DTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 D+ G L PE+ V +L P+ H H++ L +AN++ I AG + AS+ G Sbjct 170 DSAGALLPEDYTARVKTLRDALRPETEIGVHTHHNLTLGIANAVAGIEAGAVRVDASLAG 229 Query 237 LGERAGNTPLEALVTTIHDK 256 +G AGN PLEAL+ ++ K Sbjct 230 MGAGAGNAPLEALIAVLNRK 249 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Rhodococcus opacus B4] Sequence ID: C1B7L0.1 Length: 340 Range 1: 161 to 245 Score:51.2 bits(121), Expect:1e-05, Method:Compositional matrix adjust., Identities:33/89(37%), Positives:46/89(51%), Gaps:11/89(12%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKYPDI-----HFEFHGHNDYDLSVANSLQAIRAGVK 228 +++ D+ G L T GV ++ Y DI H H + LSVANS+ A+ GV Sbjct 161 VYVTDSGGRL----TMNGVRDRVRAYRDILDPGTQIGIHAHENLSLSVANSVVAVEEGVT 216 Query 229 GLHASINGLGERAGNTPLEAL--VTTIHD 255 + AS+ G G AGN P+EA V +HD Sbjct 217 RVDASLAGHGAGAGNCPIEAFIAVANLHD 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Ralstonia pseudosolanacearum GMI1000] Sequence ID: Q8XSZ5.1 Length: 576 Range 1: 210 to 351 Score:51.6 bits(122), Expect:1e-05, Method:Compositional matrix adjust., Identities:40/147(27%), Positives:64/147(43%), Gaps:12/147(8%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P + + + + + I H HND +VA + A+ AG + Sbjct 210 LPATVEMATPNVYADQIEWMHRHLARRDSILLSVHPHNDRGTAVAAAELAVMAGADRVEG 269 Query 233 SINGLGERAGNTPLEALVTTIH----DKSNSKTNINEIAITEASRLVEVFSGKRISANRP 288 + G GER GN L L ++ D +++N++A R E + + P Sbjct 270 CLFGNGERTGNVDLVTLALNLYSQGIDPGLDFSHVNDVA-----RTCEDCTQLPVHPRHP 324 Query 289 IVGEDVFTQTAGVHADGDKKGNLYANP 315 VG+ VFT +G H D KKG P Sbjct 325 YVGDLVFTAFSGSHQDAIKKGFAVQKP 351 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Serratia proteamaculans 568] Sequence ID: A8GG86.1 Length: 333 Range 1: 141 to 238 Score:50.1 bits(118), Expect:2e-05, Method:Compositional matrix adjust., Identities:32/101(32%), Positives:50/101(49%), Gaps:5/101(4%) Query 155 SPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQ--KYPDIHFEFHGHNDY 212 SP + E L + + + D+ G L P++ + ++ K P I FH HN+ Sbjct 141 SPAELADQAELLVGYGAQAVGIMDSAGSLLPQDVTARITAMRMQVKVPLI---FHAHNNL 197 Query 213 DLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTI 253 ++VANSL A++AG + G G AGNT LE L+ + Sbjct 198 GMAVANSLAAVQAGAGIIDGCARGFGAGAGNTQLEVLIPVL 238 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Agrobacterium fabrum str. C58] Sequence ID: Q8UD63.2 Length: 558 Range 1: 33 to 490 Score:50.1 bits(118), Expect:4e-05, Method:Compositional matrix adjust., Identities:107/483(22%), Positives:192/483(39%), Gaps:80/483(16%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQ------- 63 V LRDG Q+ K + K LL+ + +EI S+ + + + Sbjct 33 CSVDLRDGNQSLVNPMGHDRKARMFKLLLE-MGFKEIEIGFPSASQTDFDFARWCVEEGN 91 Query 64 -------KIMEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQL 116 +++ E +T E L NK + +S +++ + G H KQ+ Sbjct 92 VPDDVSLQVLVQCRPELITRTFEALE--GANKPIIHFYNSTSELQRRVVFGKDVHGIKQI 149 Query 117 GKTPKEFFTDVS------FVIEYAIKS--GLKINVYLEDWSNGFRNSPDYVKSLVEHLSK 168 + TD++ F EY+ +S G ++ V LE ++VE + Sbjct 150 AVDAAKMITDMAAKAGGGFRFEYSPESFTGTELEVALE-----------ICNAVVEVVKP 198 Query 169 EHIERIFL--PDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAI 223 ++ L P T+ + +P ++ + I ++ H HND +A + A+ Sbjct 199 TADNKLILNLPSTVEMATPNIYADQIEWMCRNIDNRENVIISLHPHNDRGTGIAATELAL 258 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKR 282 AG + ++ G GER GN + L ++ + + + + +I +A + E + Sbjct 259 MAGADRVEGTLFGNGERTGNVDVVTLALNMYTQGVDPELDCRDIERIKA--VYEYSNEMT 316 Query 283 ISANRPIVGEDVFTQTAGVHADGDKKGN---LYAN---------PILPERFGRKRSYA-- 328 I P VGE V+T +G H D KG AN PI P+ G RSY Sbjct 317 IPERHPYVGELVYTAFSGSHQDAINKGMKAIKVANHPVWEVPYLPIDPKDVG--RSYEAI 374 Query 329 --LGKLAGKASISENVKQ-LGMVLSEVVLQKVLERVIELGDQNKLVTPEDLPFIIADVSG 385 + +GK I+ ++Q G+ L + + E + + D+ + P + Sbjct 375 IRINSQSGKGGIAYILQQDYGINLPRNLQVEFREDIQRITDEEGVELPA------KRIYE 428 Query 386 RTGEKVLT-----IKSCNIHSGI-----GIRPHAQIELEYQGKIHKEISEGDGGYDAFMN 435 R E+ +T IK + H+ G+R A E+ G++ + +G G D F+N Sbjct 429 RFIERYVTQPNARIKFVDHHTYPAGDFKGVRIVAA-EITDNGEVKRIEGKGTGPIDGFIN 487 Query 436 ALT 438 AL+ Sbjct 488 ALS 490 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Streptomyces coelicolor A3(2)] Sequence ID: O31046.2 Length: 573 Range 1: 219 to 354 Score:49.7 bits(117), Expect:4e-05, Method:Compositional matrix adjust., Identities:38/137(28%), Positives:59/137(43%), Gaps:4/137(2%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ +P + F+ + + + + H HND +VA + A+ AG + Sbjct 219 LPATVERSTPSTHADRFEWMGRNLSRREHVCLSVHPHNDRGTAVAAAELALMAGADRIEG 278 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L + + I+ I E R E + + P VG+ Sbjct 279 CLFGQGERTGNVDLVTLGMNLFSQ-GVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGD 337 Query 293 DVFTQTAGVHADGDKKG 309 V+T +G H D KKG Sbjct 338 LVYTSFSGSHQDAIKKG 354 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Cupriavidus taiwanensis LMG 19424] Sequence ID: B2AHM5.1 Length: 569 Range 1: 210 to 486 Score:49.7 bits(117), Expect:4e-05, Method:Compositional matrix adjust., Identities:63/278(23%), Positives:108/278(38%), Gaps:17/278(6%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ +P + + + + + I H HND +VA + A+ AG + Sbjct 210 LPTTVECSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADRVEG 269 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L ++ + + ++ I + VE + + P VG+ Sbjct 270 CLFGNGERTGNVDLVTLALNLYTQGVAP-ELDFSDIDAVRQCVEHCNQLPVHPRHPYVGD 328 Query 293 DVFTQTAGVHADGDKKGNLYAN----------PILPERFGRKRSYAL--GKLAGKASISE 340 VFT +G H D +KG PI P GR + +GK ++ Sbjct 329 LVFTAFSGSHQDAIRKGFAQQQPDAIWEVPYLPIDPADLGRSYDAVIRVNSQSGKGGMAY 388 Query 341 NVKQLGMVLSEVVLQKVLERVIE-LGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNI 399 ++Q+ + LQ R ++ + D L D + + E L S + Sbjct 389 LLEQVHGLYLPRRLQIEFSRAVQAMTDDTGLEASADDLYGLFRREYLARETPLRYVSHQL 448 Query 400 HSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNAL 437 S +++E G+ G+G DAF++AL Sbjct 449 ASDATGATAITVQMERDGQPCTVRGTGNGPIDAFIDAL 486 >RecName: Full=Isopropyl malate synthase gloH; AltName: Full=L-homotyrosine biosynthesis sub-cluster protein gloH; AltName: Full=Pneumocandin biosynthesis cluster protein H [Glarea lozoyensis ATCC 20868] Sequence ID: S3D9F8.1 Length: 617 Range 1: 50 to 365 Score:49.7 bits(117), Expect:5e-05, Method:Compositional matrix adjust., Identities:68/321(21%), Positives:127/321(39%), Gaps:27/321(8%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAA 70 L LRDG Q + +K + + LL + ++E++ S+ E + ++++E Sbjct 50 LSTDLRDGNQALPNPMTLQQKWRMFQ-LLVSIGFTQIEVSFPCASQTEFDFTRQLIETPG 108 Query 71 TEQLTERIEILGFVDGNK---TVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDV 127 +E+L + +V +K + +L L S ++ E L + E+ Sbjct 109 ATPDDVTLEVLSPCREDAIATSVRSLKGAKQAILFLYLATSDNYRETVLQLSEAEWLDQA 168 Query 128 SFVIEYA----------IKSGLKINVYLEDWSNGFRNSPDYVKSLVEHL------SKEHI 171 +EYA ++ ED++N P+ L E + SK++ Sbjct 169 KRCVEYARSITKDDPENCRTKWSFGFGFEDFANA---RPEAALRLGETIKTAWGPSKDNP 225 Query 172 ERIFLPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVK 228 + L ++ +P V+ I + + H HND +VA++ A AG Sbjct 226 VILGLATSVEATTPNVFADQVEYFSRNITEREKVCISIHTHNDRGGAVASAELACLAGGD 285 Query 229 GLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRP 288 + + G GERAGN L + + +T ++ + E R+ E + + +P Sbjct 286 RVEGCLFGNGERAGNLDLITCSMNMFTQ-GIETGLDFSDLLEIRRVYEEVTNLPVHPRQP 344 Query 289 IVGEDVFTQTAGVHADGDKKG 309 G+ F AG H D +KG Sbjct 345 YSGDFYFRAFAGAHQDAIRKG 365 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Corynebacterium glutamicum R] Sequence ID: A4QAP0.1 Length: 616 Range 1: 62 to 381 Score:49.3 bits(116), Expect:7e-05, Method:Compositional matrix adjust., Identities:75/334(22%), Positives:134/334(40%), Gaps:41/334(12%) Query 3 KVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV 62 K+ + V LRDG Q S K + + L+Q + +E+ S+ + + V Sbjct 62 KITVAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVQ-MGFKEIEVGFPSASQTDFDFV 120 Query 63 QKIMEWAATEQLTERIEILGFVDGNKTV---DWIKDSGAKVLNLLTKGSLHHLEKQLGKT 119 ++I+E + + + + I V + + + GAK + + S L++ + Sbjct 121 REIIE---KDMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNV--- 174 Query 120 PKEFFTDVSFVIEYAIKSGLKINVYLEDWSNG---FRNSPD--------YVKSLVEHL-- 166 F D V + A + I +D+ + ++ SP+ Y K +V+ + Sbjct 175 --VFRMDKDQVKKLATDAAELIKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDAVVE 232 Query 167 ----SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANS 219 + E+ I LP T+ +++P ++ + + + + I H HND V + Sbjct 233 VMDPTPENPMIINLPSTVEMITPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAA 292 Query 220 LQAIRAGVKGLHASINGLGERAGNTPLEAL----VTTIHDKSNSKTNINEIAITEASRLV 275 AG + + G GER GN L L +T D T+I +I T V Sbjct 293 ELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFTDIRQIRST-----V 347 Query 276 EVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 E + R+ P G+ VFT +G H D KG Sbjct 348 EYCNQLRVPERHPYAGDLVFTAFSGSHQDAVNKG 381 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 6; Short=HOA 6; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 6; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 6 [Rhodococcus opacus B4] Sequence ID: C1BE28.1 Length: 339 Range 1: 162 to 260 Score:48.5 bits(114), Expect:7e-05, Method:Compositional matrix adjust., Identities:34/104(33%), Positives:52/104(50%), Gaps:10/104(9%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKYPDIHFE-----FHGHNDYDLSVANSLQAIRAGVK 228 +++ D+ G L T GV ++ Y D+ E H H + LSVANS+ A+ GV Sbjct 162 VYVTDSGGRL----TMDGVRDRVRAYRDVLDEGTEIGIHAHENLSLSVANSVVAVEEGVT 217 Query 229 GLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 + AS+ G G AGN P+E + + D K N A+ +A+ Sbjct 218 RVDASLAGHGAGAGNCPIEPFI-AVADLQGWKHNSALFALQDAA 260 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 7; Short=HOA 7; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 7; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 7 [Rhodococcus jostii RHA1] Sequence ID: Q0RWN1.1 Length: 336 Range 1: 2 to 239 Score:48.1 bits(113), Expect:8e-05, Method:Compositional matrix adjust., Identities:64/260(25%), Positives:105/260(40%), Gaps:36/260(13%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV--- 62 TRL I DVTLRDG + ++ IA L VD +E++ G T Sbjct 2 TRLYIQDVTLRDGMHAIRHRLAPAQLRTIAAAL-DAAGVDAIEVSHGDGLAGSSLTYGPG 60 Query 63 -QKIMEW--AATEQLTERIEILGFVDGNKTVDWIKDS---GAKVLNLLTKGSLHHLEKQL 116 EW AA + +T + G T+ ++ + G + + + T + + Q Sbjct 61 SNTDWEWITAAADVVTNAKLTTLLLPGIGTIAELEHAHTLGVRSVRVATHATEADIAVQH 120 Query 117 GKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFL 176 +E DVS G + ++ +P + + + + +++ Sbjct 121 ISRARELGMDVS---------GFLMMSHMA--------APAELARQAKLMEQAGAHCVYV 163 Query 177 PDTLGVLSPEETFQGVDSLIQKYPDIHFE-----FHGHNDYDLSVANSLQAIRAGVKGLH 231 D+ G L T V ++ Y D+ E H H + LSVANS+ A+ GV + Sbjct 164 TDSGGRL----TMSDVRDRVRAYRDVLDEATQIGIHAHENLSLSVANSVVAVEEGVTRVD 219 Query 232 ASINGLGERAGNTPLEALVT 251 AS+ G G AGN P+EA + Sbjct 220 ASLAGQGAGAGNCPIEAFIA 239 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Thermobifida fusca YX] Sequence ID: Q47RM9.1 Length: 568 Range 1: 247 to 567 Score:48.1 bits(113), Expect:1e-04, Method:Compositional matrix adjust., Identities:81/353(23%), Positives:135/353(38%), Gaps:74/353(20%) Query 202 IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIH----DKS 257 + H HND +VA + A+ AG + + G GER GN L L + D Sbjct 247 VCLSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGHGERTGNVCLVTLGLNLFSQGIDPM 306 Query 258 NSKTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG-------- 309 +NI+EI R VE + ++ P G+ V+T +G H D KKG Sbjct 307 IDFSNIDEI-----RRTVEHCTQLPVNPRHPYGGDLVYTAFSGSHQDAIKKGFHALEADA 361 Query 310 ------------NLYANPILPERFGRKRSYAL--GKLAGKASISENVKQLGMVLSEVVLQ 355 N+ PI P+ GR + +GK +S +++ + LQ Sbjct 362 AAAGVPVDEYRWNMPYLPIDPKDVGRTYEAVIRVNSQSGKGGVSYVLQRDYSIDLPRRLQ 421 Query 356 KVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVL-----TIKSCNIHSGIGIRPHAQ 410 RV++ F A+ +GE++ T S + + R Sbjct 422 IEFSRVVQQ-------------FADAEGGEFSGERIWEIFTDTYLSEGVVGVMAYRSETS 468 Query 411 IELEY--------QGKIHKEISEGDGGYDAFMNALTKITNRLGISIPKLIDY-EVRIPPG 461 + EY +G+I + G+G AF++AL + +L +++DY E + G Sbjct 469 EDGEYCISADVRLRGEIREITGTGNGPISAFVDALAGVGFKL-----RVLDYSEHALSEG 523 Query 462 G--KTDALVETRITWNKSLDLEEDQTFKTMGVHPDQTVAAVHATEKMLNQILQ 512 G + A VE + N +G+ + T A++ A +N+ Q Sbjct 524 GDARAAAYVEAEVDGN---------VLWGVGISSNITTASLKAVCSAVNRAQQ 567 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Rhodococcus erythropolis PR4] Sequence ID: C0ZU50.1 Length: 342 Range 1: 163 to 241 Score:47.4 bits(111), Expect:2e-04, Method:Compositional matrix adjust., Identities:30/83(36%), Positives:43/83(51%), Gaps:9/83(10%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKYPDIHFE-----FHGHNDYDLSVANSLQAIRAGVK 228 +++ D+ G L V ++ Y DI E H H + LSVANS+ A++ GV Sbjct 163 VYVTDSGGRL----VMNDVADRVRAYRDILDEGTEIGIHAHENLSLSVANSVVAVQNGVT 218 Query 229 GLHASINGLGERAGNTPLEALVT 251 + AS+ G G AGN PLEA + Sbjct 219 RVDASLAGHGAGAGNCPLEAFIA 241 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Azoarcus olearius] Sequence ID: A1K893.1 Length: 346 Range 1: 6 to 263 Score:47.0 bits(110), Expect:2e-04, Method:Compositional matrix adjust., Identities:70/276(25%), Positives:118/276(42%), Gaps:27/276(9%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 TR+ + D+TLRDG + + + IA+ L D+ I V+ G+ + Sbjct 6 TRITVHDMTLRDGMHPKRHLMTLEQMKTIAQGL------DQAGIPLIEVTHGDGLGGSSV 59 Query 66 MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLE--KQLGKTPKEF 123 + E E LG V + +K + L L G++ HL+ +LG Sbjct 60 -NYGFPAHTDE--EYLGAV-----IPLMKQAKVSALLLPGIGTVDHLKMAHELGVNTIRV 111 Query 124 FTDVSFV------IEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 T + I YA K G+ +L NSP+ + + + I++ Sbjct 112 ATHCTEADVSEQHIRYARKLGMDTVGFL---MMAHMNSPEGLVQQAKLMESYGANCIYVT 168 Query 178 DTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 D+ G L P+ + ++ P+ FHGH++ + VANS+ AI AG + A+ G Sbjct 169 DSAGHLLPDTVKARIGAVRAALKPETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAG 228 Query 237 LGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 LG AGNTP+E L+ + D +T ++ I + + Sbjct 229 LGAGAGNTPMEVLI-AVCDLMGIETGVDVFKIQDVA 263 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Azoarcus olearius] Sequence ID: A1K6Y4.1 Length: 342 Range 1: 6 to 263 Score:47.0 bits(110), Expect:2e-04, Method:Compositional matrix adjust., Identities:70/276(25%), Positives:118/276(42%), Gaps:27/276(9%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKI 65 TR+ + D+TLRDG + + + IA+ L D+ I V+ G+ + Sbjct 6 TRITVHDMTLRDGMHPKRHLMTLEQMKTIAQGL------DQAGIPLIEVTHGDGLGGSSV 59 Query 66 MEWAATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLE--KQLGKTPKEF 123 + E E LG V + +K + L L G++ HL+ +LG Sbjct 60 -NYGFPAHTDE--EYLGAV-----IPLMKQAKVSALLLPGIGTVDHLKMAHELGVNTIRV 111 Query 124 FTDVSFV------IEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLP 177 T + I YA K G+ +L NSP+ + + + I++ Sbjct 112 ATHCTEADVSEQHISYARKLGMDTVGFL---MMAHMNSPEGLVQQAKLMESYGANCIYVT 168 Query 178 DTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASING 236 D+ G L P+ + ++ P+ FHGH++ + VANS+ AI AG + A+ G Sbjct 169 DSAGHLLPDTVKARISAVRDALKPETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAG 228 Query 237 LGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 LG AGNTP+E L+ + D +T ++ I + + Sbjct 229 LGAGAGNTPMEVLI-AVCDLMGIETGVDVFKIQDVA 263 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Mycobacteroides abscessus ATCC 19977] Sequence ID: B1MJT9.1 Length: 333 Range 1: 161 to 239 Score:46.6 bits(109), Expect:3e-04, Method:Compositional matrix adjust., Identities:31/83(37%), Positives:43/83(51%), Gaps:9/83(10%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKYPDI---HFEF--HGHNDYDLSVANSLQAIRAGVK 228 +++ D+ G L T V ++ Y D+ H E H H + LSVANS+ A+ G Sbjct 161 VYVTDSGGRL----TMPMVRDRVRAYRDVLDSHTEIGIHAHENLSLSVANSVVAVEEGAT 216 Query 229 GLHASINGLGERAGNTPLEALVT 251 + AS+ G G AGN PLEA V Sbjct 217 RIDASLAGHGAGAGNCPLEAFVA 239 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Paenarthrobacter aurescens TC1] Sequence ID: A1R6V4.1 Length: 579 Range 1: 45 to 354 Score:47.0 bits(110), Expect:3e-04, Method:Compositional matrix adjust., Identities:77/330(23%), Positives:125/330(37%), Gaps:53/330(16%) Query 13 VTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA--- 69 V LRDG Q S + KL + + L+ K+ +E+ S+ + + V++++E Sbjct 45 VDLRDGNQALIDPMSPARKLKMFQLLV-KMGYKEIEVGFPSASQTDFDFVRQLIEGGHIP 103 Query 70 ----------ATEQLTERIEILGFVDGNKTVDWIKDSGA-------------KVLNLLTK 106 A E L ER V + + + +S + +L++ + Sbjct 104 DDVSIQVLTQAREHLIERT-YESLVGAKQAIVHLYNSTSVLQRRVVFNQDEDGILDIALQ 162 Query 107 GSLHHLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINV-YLEDWSNGFRNSPDYVKSLVEH 165 G+ +L K +E TD EY+ +S + Y N + V Sbjct 163 GA------RLCKKYEETLTDTHITYEYSPESFTGTELEYAARVCNAIAD--------VFE 208 Query 166 LSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIH------FEFHGHNDYDLSVANS 219 S + I LP T+ + +P DS+ + ++H H HND VA + Sbjct 209 ASADKQVIINLPATVEMATPNVY---ADSIEWMHRNLHPREGIIISLHPHNDRGTGVAAA 265 Query 220 LQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFS 279 AG + + G GER GN L L + + I+ I E R VE + Sbjct 266 ELGYLAGADRIEGCLFGNGERTGNVDLVTLGLNMFVQGVDPM-IDFSDIDEIRRTVEYCN 324 Query 280 GKRISANRPIVGEDVFTQTAGVHADGDKKG 309 + P G+ VFT +G H D KKG Sbjct 325 QLPVPERSPYGGDLVFTAFSGSHQDAIKKG 354 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Catenulispora acidiphila DSM 44928] Sequence ID: C7QJN7.1 Length: 573 Range 1: 36 to 352 Score:47.0 bits(110), Expect:3e-04, Method:Compositional matrix adjust., Identities:72/327(22%), Positives:130/327(39%), Gaps:40/327(12%) Query 13 VTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATE 72 V LRDG Q T+ K + L ++ +E+A S+ + + V+ + A + Sbjct 36 VDLRDGNQALAEPMDTARKTKMFDLFL-RMGYKEIEVAYPSASQTDFDFVRSL---AVRD 91 Query 73 QLTERIEILGF--------------VDG--NKTVDWIKDSGAKVLNLLTKGS----LHHL 112 + E + I F V+G N V + +L+ +GS L + Sbjct 92 DIPEDVTISVFTPARPELIERTFESVEGLPNVLVHLYTATAPAWRDLVLRGSRAEVLALI 151 Query 113 EKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSK---E 169 E G K D ++ +G + + N PDYV + + +++ Sbjct 152 EDAAGLVAK--LADQRLGTKHGPGAGRMRFEFSPEVFN--LTEPDYVIEVCDRVTEIWDA 207 Query 170 HIERIF---LPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAI 223 +R LP T+ V +P ++ + + + + H HND VA + A+ Sbjct 208 CADRPVVHNLPATVEVATPNVYADQIEYMSRSLARREHVILSVHPHNDRGTGVACAELAV 267 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKR 282 AG + + + G GER GN L L +H + + ++++I +A +VE + Sbjct 268 LAGAQRVEGCLFGNGERTGNVDLVTLALNLHAQGVDPMIDLSDIDAVKA--VVEECNRIP 325 Query 283 ISANRPIVGEDVFTQTAGVHADGDKKG 309 + P G+ V+T +G H D KG Sbjct 326 VHVRHPYGGDLVYTAFSGTHQDAISKG 352 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Kocuria rhizophila DC2201] Sequence ID: B2GHT7.1 Length: 584 Range 1: 219 to 524 Score:47.0 bits(110), Expect:4e-04, Method:Compositional matrix adjust., Identities:74/314(24%), Positives:125/314(39%), Gaps:43/314(13%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P ++ + + + + DI H HND VA + AG + Sbjct 219 LPATVEMATPNVYADSIEWMGRHLYQREDIILSLHPHNDRGTGVAAAELGYLAGADRIEG 278 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L + + I+ I E R VE + + P G+ Sbjct 279 CLFGNGERTGNVDLVTLGLNLLTQ-GVDPQIDFSDIEEIRRTVEYCNQLPVPERSPYGGD 337 Query 293 DVFTQTAGVHADGDKKG--------------------NLYANPILPERFGRKRSYAL--G 330 VFT +G H D KKG + PI P+ GR + Sbjct 338 LVFTAFSGSHQDAIKKGFEAMERDAEQQGVGVDELEWAVPYLPIDPKDVGRSYEAVIRVN 397 Query 331 KLAGKASISENVK-QLGMVL---SEVVLQKVLERVIELGDQNKLVTPEDLPFIIAD--VS 384 +GK ++ +K + G+ L +++ V+++ E V+ + L I D + Sbjct 398 SQSGKGGVAYLLKSEYGIDLPRRAQIEFSGVVQKFTETSGSE--VSAQQLWTIFRDEYLP 455 Query 385 GRTGEKV----LTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTKI 440 R G I S + H+ +I L+ G+ + ++G G DA +N + Sbjct 456 SRDGSGSTWGHYRITSISTHAEDQANTVLEIGLDVGGEHKERTAQGTGPIDALIN----L 511 Query 441 TNRLGISIPKLIDY 454 NR G+ + +L+DY Sbjct 512 FNREGMDV-RLLDY 524 >RecName: Full=2-isopropylmalate synthase 2, mitochondrial; AltName: Full=Alpha-IPM synthase 2; AltName: Full=Alpha-isopropylmalate synthase 2; AltName: Full=Alpha-isopropylmalate synthase II; Flags: Precursor [Saccharomyces cerevisiae S288C] Sequence ID: Q12166.1 Length: 604 Range 1: 240 to 375 Score:46.6 bits(109), Expect:4e-04, Method:Compositional matrix adjust., Identities:38/137(28%), Positives:59/137(43%), Gaps:4/137(2%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V SP + + + I + + H HND VA + + AG + Sbjct 240 LPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEG 299 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L + ++ + S N++ +T S +V + I P GE Sbjct 300 CLFGNGERTGNVDLVTVAMNMYTQGVSP-NLDFSDLTSISEIVHRCNKIPIPPRAPYGGE 358 Query 293 DVFTQTAGVHADGDKKG 309 V + +G H D KKG Sbjct 359 LVVSAFSGSHQDAIKKG 375 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Parafrankia sp. EAN1pec] Sequence ID: A8LEP8.1 Length: 336 Range 1: 190 to 241 Score:46.2 bits(108), Expect:4e-04, Method:Compositional matrix adjust., Identities:22/52(42%), Positives:27/52(51%), Gaps:0/52(0%) Query 200 PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVT 251 PD H H + LSVANS A+ G + AS+ G G AGN P+E V Sbjct 190 PDTQIGIHAHENLSLSVANSFAAVEEGAYRVDASLAGQGAGAGNCPIEPFVA 241 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Shewanella woodyi ATCC 51908] Sequence ID: B1KJK9.1 Length: 339 Range 1: 165 to 263 Score:46.2 bits(108), Expect:4e-04, Method:Compositional matrix adjust., Identities:33/100(33%), Positives:53/100(53%), Gaps:2/100(2%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I+ D+ G + ++ F+ + L PD FHGH++ L VANSL A+ AG + + Sbjct 165 IYCTDSAGYMLQDDVFERISVLRDGLKPDTQIGFHGHHNLALGVANSLTAVEAGAERIDG 224 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 S GLG AGNTPLE + + + T+++ + A+ Sbjct 225 SAAGLGAGAGNTPLEVF-NAVATRMGASTDVDVFKLMAAA 263 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Corynebacterium efficiens YS-314] Sequence ID: Q8FU05.1 Length: 581 Range 1: 209 to 346 Score:46.6 bits(109), Expect:4e-04, Method:Compositional matrix adjust., Identities:37/139(27%), Positives:58/139(41%), Gaps:4/139(2%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I LP T+ +++P ++ + + + + I H HND VA + AG + Sbjct 209 INLPATVEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVAAAELGYMAGADRI 268 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 + G GER GN L L + + ++ I R VE + R+ P Sbjct 269 EGCLFGNGERTGNVCLVTLALNMLTQG-VDPQLDFSDIKHIRRTVEYCNQLRVPERHPYG 327 Query 291 GEDVFTQTAGVHADGDKKG 309 G+ VFT +G H D KG Sbjct 328 GDLVFTAFSGSHQDAINKG 346 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Corynebacterium glutamicum ATCC 13032] Sequence ID: P42455.1 Length: 616 Range 1: 62 to 381 Score:46.6 bits(109), Expect:4e-04, Method:Compositional matrix adjust., Identities:75/339(22%), Positives:130/339(38%), Gaps:51/339(15%) Query 3 KVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV 62 K+ + V LRDG Q S K + + L+Q + +E+ S+ + + V Sbjct 62 KITVAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVQ-MGFKEIEVGFPSASQTDFDFV 120 Query 63 QKIMEWA-------------ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSL 109 ++I+E A E L R N V + + N++ + Sbjct 121 REIIEKGMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDK 180 Query 110 HHLEK------QLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLV 163 ++K +L KT + + D ++ +Y+ +S V +Y K +V Sbjct 181 VQVKKLATDAAELIKTIAQDYPDTNWRWQYSPESFTGTEV-------------EYAKEVV 227 Query 164 EHL------SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDL 214 + + + E+ I LP T+ +++P ++ + + + + I H HND Sbjct 228 DAVVEVMDPTPENPMIINLPSTVEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGT 287 Query 215 SVANSLQAIRAGVKGLHASINGLGERAGNTPLEAL----VTTIHDKSNSKTNINEIAITE 270 V + AG + + G GER GN L L +T D T+I +I T Sbjct 288 GVGAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFTDIRQIRST- 346 Query 271 ASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 VE + R+ P G+ VFT +G H D KG Sbjct 347 ----VEYCNQLRVPERHPYGGDLVFTAFSGSHQDAVNKG 381 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Helicobacter hepaticus ATCC 51449] Sequence ID: Q7VH30.1 Length: 558 Range 1: 33 to 369 Score:46.6 bits(109), Expect:5e-04, Method:Compositional matrix adjust., Identities:80/359(22%), Positives:137/359(38%), Gaps:68/359(18%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEW-- 68 V LRDG Q S EK+ K LL K+ +E+ S+ E ++ ++E Sbjct 33 CSVDLRDGNQALITPMSLEEKITFFKLLL-KVGFKEIEVGFPAASETEYRFLRTLIEEDL 91 Query 69 ----AATEQLTE-RIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 + + LT+ R I+ KT + ++ ++++ S E+ K+ E Sbjct 92 IPDDVSVQVLTQAREHII-----KKTFESLEGCKNAIVHVYNSTSYAQREQVFRKSKDEI 146 Query 124 ----------------FTDVSFVIEYAIKS--GLKINVYLEDWSNGFRN--SPDYVKSLV 163 T +F EY+ +S G +++ LE N + P K L+ Sbjct 147 KHIACEGAICLKESAAATKGNFRFEYSPESFSGTEVDYALE-VCNAVIDIFEPTLEKKLI 205 Query 164 EHLSKEHIERIFLPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSL 220 I LP T+ + P V+ + ++ ++ H HND ++A++ Sbjct 206 ----------INLPVTVEMSLPHIYASQVEYMSKHLKNRENVLISLHPHNDRGCAIADAE 255 Query 221 QAIRAGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNSKTNINEIAITEASRLVE 276 + AG + ++ G GER GN + L +H D +NI I + E Sbjct 256 LGLLAGADRIEGTLFGNGERTGNVDIITLAMNMHSHGVDPKLDFSNIPSIC-----DVYE 310 Query 277 VFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYAN------------PILPERFGR 323 + ++ +P G+ VF +G H D KG Y PI P+ GR Sbjct 311 KVTKMQVYERQPYSGKLVFAAFSGSHQDAIAKGMAYHKEHNLSTWSVPYLPIDPKDVGR 369 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Mycobacterium sp. KMS] Sequence ID: A1UQA1.1 Length: 349 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Mycobacterium sp. MCS] Sequence ID: Q1B0P6.1 Length: 349 Range 1: 16 to 271 Score:46.2 bits(108), Expect:5e-04, Method:Compositional matrix adjust., Identities:66/279(24%), Positives:109/279(39%), Gaps:37/279(13%) Query 8 LEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETV----Q 63 L I DVTLRDG S EK+ L VD +E+ G T Sbjct 16 LYIQDVTLRDGMHAMRHRIS-PEKVAAIAGALDTAGVDAIEVTHGDGLAGHSLTYGPGSN 74 Query 64 KIMEW-AATEQLTERIEILGFV-DGNKTVDWIKDS---GAKVLNLLTKGSLHHLEKQLGK 118 EW A + R ++ + G TV ++ + G + + T + + Q Sbjct 75 TDWEWIEAAADVVHRAKLTTLLLPGVGTVRELEHAYKLGVTSVRVATHCTEADVSAQHIG 134 Query 119 TPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIFLPD 178 T +E DVS G + +L + P ++ + + + +++ D Sbjct 135 TARELGMDVS---------GFLMMSHLAE--------PSHLAAQAKLMESYGAHCVYVTD 177 Query 179 TLGVLSPEETFQGVDSLIQKYPDI-----HFEFHGHNDYDLSVANSLQAIRAGVKGLHAS 233 + G L T V ++ Y D+ H H + LSVAN++ A+ GV + AS Sbjct 178 SGGRL----TMGSVRDRVRAYRDVLDAGTQIGIHAHQNLSLSVANTVVAVEEGVTRVDAS 233 Query 234 INGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 + G G AGN P+E + + D K N + + +A+ Sbjct 234 LAGHGAGAGNCPIEPFI-AVADLHGWKHNCDLFGLQDAA 271 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Cupriavidus metallidurans CH34] Sequence ID: Q1LNS4.1 Length: 348 Range 1: 145 to 263 Score:45.8 bits(107), Expect:5e-04, Method:Compositional matrix adjust., Identities:32/120(27%), Positives:64/120(53%), Gaps:2/120(1%) Query 154 NSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDY 212 NSP+ + + + +++ D+ G + P++ + ++ + P+ FHGH++ Sbjct 145 NSPEGLVGQAKLMESYGANCVYITDSAGYMLPDDVRARLGAVREALKPETELGFHGHHNL 204 Query 213 DLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 + +ANS+ A+ G + A+ GLG AGNTP+E LV + D+ +T ++ AI + + Sbjct 205 AMGIANSIAAVECGATRIDAASAGLGAGAGNTPMEVLV-AVCDRMGIQTGVDVWAIQDVA 263 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Azotobacter vinelandii DJ] Sequence ID: C1DE40.1 Length: 557 Range 1: 36 to 353 Score:46.2 bits(108), Expect:6e-04, Method:Compositional matrix adjust., Identities:70/327(21%), Positives:126/327(38%), Gaps:31/327(9%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA- 69 L LRDG Q+ ++K+ K L+Q + + +E+ S+ + + V++++E Sbjct 36 LSTDLRDGNQSLIEPMDAAKKMRFFKTLVQ-VGLKEIEVGFPSASQTDFDFVRELIEGGH 94 Query 70 ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF-TDVS 128 + +T I++L + D + + + L K +H+ + F D Sbjct 95 IPDDVT--IQVL-----TQARDDLIERTFESLKGAKKAIVHYYNACAPSFRRIVFDQDKE 147 Query 129 FVIEYAIKSGLKIN---VYLEDWSNGFRNSPDYVKS------------LVEHLSKEHIER 173 V A+ +G I + GF SP+ S +VE R Sbjct 148 GVKRIAVAAGRTIKRLAAAAPETRWGFEYSPEVFSSTESDFAVEVCNAVVEVFQPTPANR 207 Query 174 IFL--PDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVK 228 + L P T+ +P ++ + + + H HND VA S + AG Sbjct 208 LILNLPATIECATPNHYADQIEWFCRHVDRRDSVIVSLHTHNDRGTGVAASELGLMAGAD 267 Query 229 GLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRP 288 + + G GER GN L L ++ + ++ I ++VE + + P Sbjct 268 RVEGCLFGNGERTGNVDLVTLALNLYTQ-GVDPGLDFSDIDAVRKVVEECNQLPVHPRHP 326 Query 289 IVGEDVFTQTAGVHADGDKKGNLYANP 315 VG+ V T +G H D +KG +P Sbjct 327 YVGDLVHTAFSGSHQDAIRKGFAQQDP 353 >RecName: Full=Pyruvate carboxylase 1; AltName: Full=Pyruvic carboxylase 1; Short=PCB 1 [Caenorhabditis elegans] Sequence ID: O17732.1 Length: 1175 Range 1: 695 to 838 Score:46.2 bits(108), Expect:6e-04, Method:Compositional matrix adjust., Identities:40/151(26%), Positives:68/151(45%), Gaps:14/151(9%) Query 130 VIEYAIKSGLKINVYLEDWSNGFRNSPD--YVKSLVEHLSKEHIERIFLPDTLGVLSPEE 187 V+E AI Y D ++ R+ D Y +L + L K + + D GVL PE Sbjct 695 VVEAAI-------AYTGDVTDKSRDKYDLKYYLNLADQLVKAQAHILSIKDMAGVLKPEA 747 Query 188 TFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLE 247 + +L K+PDI H H+ VA L+ +AG + A+++ + + Sbjct 748 AKLLIGALRDKFPDIPIHVHTHDTSGAGVAAMLECAKAGADVVDAAVDSMSGMTSQPSMG 807 Query 248 ALVTTI----HDKSNSKTNINEI-AITEASR 273 A+V ++ HD S +I++ A E++R Sbjct 808 AIVASLQGTKHDTGLSLDDISKYSAYWESTR 838 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Methylocella silvestris BL2] Sequence ID: B8ESV2.1 Length: 346 Range 1: 8 to 280 Score:45.4 bits(106), Expect:7e-04, Method:Compositional matrix adjust., Identities:74/296(25%), Positives:129/296(43%), Gaps:38/296(12%) Query 7 RLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET----V 62 +L + DVTLRDG + +S IA+ L + +VD +EI+ G Sbjct 8 KLYVQDVTLRDGMHSVRHQYSLDAVRAIARAL-DRAHVDAIEISHGDGITGSTFNYGFGA 66 Query 63 QKIMEWAAT---EQLTERIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSLHHLEKQL 116 EW A E RI +L + G TV +K ++GA+ + + T + + +Q Sbjct 67 HDDTEWIAAVAGECKFSRITVL-LLPGIGTVHDLKYACEAGARSVRVATHCTEADVSRQ- 124 Query 117 GKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEH---LSKEHIER 173 I++G K+ + + +P V+ LVE + E Sbjct 125 -----------------HIEAGRKLGMDTVGFLMMAHMAP--VEKLVEQALLMESYGAEC 165 Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +++ D+ G L P++ + V ++ P+ H H++ L VAN++ I AG + A Sbjct 166 VYVTDSAGALLPKQYAERVKAVRGALKPETEIGVHTHHNLTLGVANAVAGIEAGAVRVDA 225 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNIN-EIAITEASRLVEVFSGKRISANR 287 S+ G+G AGN PLEAL+ + D+ +T + + + A LV + + +R Sbjct 226 SLAGMGAGAGNAPLEALIAVL-DRMGIETGCDLHMLMDAADDLVRPLQDRPVRVDR 280 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Brucella suis 1330] Sequence ID: Q8FZC4.2 Length: 555 Range 1: 241 to 343 Score:45.8 bits(107), Expect:8e-04, Method:Compositional matrix adjust., Identities:30/107(28%), Positives:49/107(45%), Gaps:7/107(6%) Query 206 FHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINE 265 H HND +A + + AG + ++ G GER GN + L ++ + Sbjct 241 LHPHNDRGTGIAATELGLMAGADRVEGTLFGNGERTGNVDVVTLALNMYTQGIDPG---- 296 Query 266 IAITEASRLVEVFSGK---RISANRPIVGEDVFTQTAGVHADGDKKG 309 + T+ +R+ EV+ +I+ P VGE V+T +G H D KG Sbjct 297 LDCTDINRMKEVYEYSNQLKIAERHPYVGELVYTAFSGSHQDAINKG 343 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Mycobacterium leprae TN] Sequence ID: Q9CB76.1 Length: 607 Range 1: 254 to 389 Score:45.8 bits(107), Expect:8e-04, Method:Compositional matrix adjust., Identities:36/137(26%), Positives:57/137(41%), Gaps:4/137(2%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P ++ + + + + H HND +VA + AG + Sbjct 254 LPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYHAGADRIEG 313 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L + + I+ I E R VE + R+ P G+ Sbjct 314 CLFGNGERTGNVCLVTLGLNLFSR-GVDPQIDFSNIDEIRRTVEYCNKLRVHERHPYGGD 372 Query 293 DVFTQTAGVHADGDKKG 309 V+T +G H D KG Sbjct 373 LVYTAFSGSHQDAINKG 389 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Stutzerimonas stutzeri A1501] Sequence ID: A4VNV6.1 Length: 556 Range 1: 36 to 363 Score:45.4 bits(106), Expect:0.001, Method:Compositional matrix adjust., Identities:75/345(22%), Positives:135/345(39%), Gaps:54/345(15%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWA- 69 L LRDG Q+ ++K+ K L+Q + + +E+ S+ + + V++++E Sbjct 36 LSSDLRDGNQSLIEPMDAAKKMRFFKTLVQ-VGLKEIEVGFPSASQTDFDFVRELIEGGH 94 Query 70 -----ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFF 124 + LT+ E L +T + +K GAK + +H+ + F Sbjct 95 IPDDVTIQVLTQAREDLI----TRTFESLK--GAK------QAIVHYYNATAPSFRRIVF 142 Query 125 T-DVSFVIEYAIKSGLKINVYLE-----DWSNGFRNSPDYVKSLVEHLSKEHIERIF--- 175 D + VI+ A+ +G I E +W F SP+ S + E + Sbjct 143 NQDKAGVIQIAVNAGRIIKRLAEQNPETNWR--FEYSPEIFSSTEPEFAVEVCNAVIEVF 200 Query 176 -----------LPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQ 221 LP T+ +P ++ I + + H HND VA + Sbjct 201 QPTPEQKLILNLPATVEAATPNVYADQIEWFCRHIDRRDSVLVSLHTHNDRGTGVAATEL 260 Query 222 AIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSG 280 + AG + + G GER GN L + ++ + + + + ++ I ++VE + Sbjct 261 GLMAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGVDPQLDFSD--IDAVRKVVEECNQ 318 Query 281 KRISANRPIVGEDVFTQTAGVHADGDKKG-------NLYANPILP 318 + P VG+ V T +G H D +KG L+ P LP Sbjct 319 LPVHPRHPYVGDLVHTAFSGSHQDAIRKGFSQQDPNGLWEVPYLP 363 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Acidovorax sp. JS42] Sequence ID: A1W2K3.1 Length: 342 Range 1: 162 to 252 Score:45.1 bits(105), Expect:0.001, Method:Compositional matrix adjust., Identities:32/92(35%), Positives:53/92(57%), Gaps:2/92(2%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I++ D+ G L P++ + + ++ P+ FH H++ + VANS+ AI+AG + A Sbjct 162 IYVTDSAGYLLPDQVTERIAAVRAALKPETELGFHCHHNLAMGVANSIAAIQAGANRIDA 221 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNIN 264 + GLG AGNTPLE LV + D+ T ++ Sbjct 222 AAAGLGAGAGNTPLEVLVAVL-DRMGIDTGVD 252 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Ralstonia pickettii 12J] Sequence ID: B2UJF1.1 Length: 348 Range 1: 146 to 256 Score:45.1 bits(105), Expect:0.001, Method:Compositional matrix adjust., Identities:32/112(29%), Positives:60/112(53%), Gaps:2/112(1%) Query 154 NSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDY 212 NSP+ + + + I++ D+ G + P++ + ++ + P+ FHGH++ Sbjct 146 NSPEGLVKQAKLMESYGANCIYITDSAGYMLPDDVKVRLSAVREALKPETELGFHGHHNL 205 Query 213 DLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNIN 264 + +ANS+ AI G + A+ GLG AGNTP+E LV + D+ +T ++ Sbjct 206 AMGIANSIAAIECGATRIDAAAAGLGAGAGNTPMEVLV-AVCDRMGIRTGVD 256 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Burkholderia vietnamiensis G4] Sequence ID: A4JW25.1 Length: 348 Range 1: 145 to 263 Score:44.7 bits(104), Expect:0.001, Method:Compositional matrix adjust., Identities:32/120(27%), Positives:63/120(52%), Gaps:2/120(1%) Query 154 NSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDY 212 NSP+ + + + +++ D+ G + P++ + ++ P+ FHGH++ Sbjct 145 NSPEGLVRQAKLMESYGANCVYITDSAGYMLPDDVRARLGAVRDALKPETELGFHGHHNL 204 Query 213 DLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 + +ANS+ A+ G + A+ GLG AGNTP+E LV + D+ +T ++ AI + + Sbjct 205 AMGIANSIAAVECGATRIDAASAGLGAGAGNTPMEVLV-AVCDRMGIQTGVDVWAIQDVA 263 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas syringae pv. tomato str. DC3000] Sequence ID: Q886Y1.2 Length: 556 Range 1: 212 to 363 Score:45.1 bits(105), Expect:0.001, Method:Compositional matrix adjust., Identities:39/154(25%), Positives:65/154(42%), Gaps:13/154(8%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V +P + + I + + H HND VA + + AG + Sbjct 212 LPATVEVATPNIYADQIEWFGRHITRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEG 271 Query 233 SINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 + G GER GN L + ++ + N + + ++ I ++VE + + P VG Sbjct 272 CLFGNGERTGNVDLVTVALNLYTQGINPELDFSD--IDGVRKVVEECNQIPVHPRHPYVG 329 Query 292 EDVFTQTAGVHADG-------DKKGNLYANPILP 318 + V T +G H D K+G L+ P LP Sbjct 330 DLVHTAFSGSHQDAIRKGFTQQKEGELWEVPYLP 363 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Comamonas testosteroni] Sequence ID: Q83VZ3.1 Length: 350 Range 1: 165 to 245 Score:44.7 bits(104), Expect:0.001, Method:Compositional matrix adjust., Identities:28/81(35%), Positives:47/81(58%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I++ D+ G + P++ + + ++ Q P+ FHGH++ + +ANSL A+ G + A Sbjct 165 IYITDSAGYMLPDDVKERLSAVRQALKPETELGFHGHHNLAMGIANSLAAVEVGANRIDA 224 Query 233 SINGLGERAGNTPLEALVTTI 253 + GLG AGNTP+E LV Sbjct 225 AAAGLGAGAGNTPMEVLVAVC 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Schizosaccharomyces pombe 972h-] Sequence ID: O59736.2 Length: 584 Range 1: 48 to 363 Score:44.7 bits(104), Expect:0.002, Method:Compositional matrix adjust., Identities:71/323(22%), Positives:122/323(37%), Gaps:31/323(9%) Query 11 LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAA 70 L LRDG Q + EKL K LL + +E+ S+ + V+ ++E Sbjct 48 LSTDLRDGNQALPDPMNGQEKLRYFK-LLCSIGFKEIEVGFPSASQTDFAFVRHLIETPG 106 Query 71 -------TEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEF 123 LT E L +T++ ++ + ++L S E + +E Sbjct 107 LIPDDVTISALTPSREPLIL----RTIEALRGAKNATVHLYNACSPLFREVVFRNSKQET 162 Query 124 FTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIER---------- 173 D++ + + K + ++ + GF SP+ + E E Sbjct 163 L-DLAIKGSKIVTAATKNALESKETNWGFEYSPETFSDTEPDFALEVCEAVKGMWKPSAA 221 Query 174 ---IF-LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAG 226 IF LP T+ + +P + + + I + + H HND +VA + AG Sbjct 222 QPIIFNLPATVEMSTPNTYADLIEYFSTNISEREKVCVSLHPHNDRGTAVAAAELGQLAG 281 Query 227 VKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISAN 286 + + G GER GN L L ++ + S N++ + E R+ E + + Sbjct 282 GDRIEGCLFGNGERTGNVDLVTLAFNLYTQGVSP-NLDFSKLDEIIRITEDCNKINVHPR 340 Query 287 RPIVGEDVFTQTAGVHADGDKKG 309 P G VFT +G H D KG Sbjct 341 HPYAGNLVFTAFSGSHQDAISKG 363 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Rhodospirillum rubrum ATCC 11170] Sequence ID: Q2RT17.1 Length: 558 Range 1: 211 to 346 Score:44.7 bits(104), Expect:0.002, Method:Compositional matrix adjust., Identities:42/145(29%), Positives:61/145(42%), Gaps:20/145(13%) Query 176 LPDTLGVLSPEETFQGVDSLIQKYPD---IHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P ++ + P + H HND +VA + A+ AG + Sbjct 211 LPSTVEMATPNVYADQIEWFCRALPHRDRVLISLHPHNDRGTAVAAAELALMAGADRIEG 270 Query 233 SINGLGERAGNTPLEALVTTIH--------DKSNSKTNINEIAITEASRLVEVFSGKRIS 284 ++ G GER GN L L + D SN +I EIA E +RL + Sbjct 271 TLFGNGERTGNVDLVTLGMNMFTQGIDPGIDFSNID-HIREIA-EECNRL-------PVH 321 Query 285 ANRPIVGEDVFTQTAGVHADGDKKG 309 P G+ VFT +G H D KG Sbjct 322 PRHPYAGDLVFTAFSGSHQDAINKG 346 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas protegens Pf-5] Sequence ID: Q4K6V7.1 Length: 559 Range 1: 212 to 363 Score:44.7 bits(104), Expect:0.002, Method:Compositional matrix adjust., Identities:39/154(25%), Positives:65/154(42%), Gaps:13/154(8%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V +P + + I + + H HND VA + + AG + Sbjct 212 LPATVEVATPNIYADQIEWFCRNINRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEG 271 Query 233 SINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 + G GER GN L + ++ + N + + ++ I ++VE + + P VG Sbjct 272 CLFGNGERTGNVDLVTVALNLYTQGVNPELDFSD--IDGVRKVVEECNQIAVHPRHPYVG 329 Query 292 EDVFTQTAGVHADGDKKG-------NLYANPILP 318 + V T +G H D +KG L+ P LP Sbjct 330 DLVHTAFSGSHQDAIRKGFAQQKADGLWEVPYLP 363 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Verminephrobacter eiseniae EF01-2] Sequence ID: A1WLL2.1 Length: 344 Range 1: 165 to 245 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:31/81(38%), Positives:46/81(56%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I++ D+ G L PE V ++ + P+ FHGH++ + VANS+ AI AG + A Sbjct 165 IYVTDSAGHLLPETVKTRVGAVREALKPETELGFHGHHNLAMGVANSIAAIEAGANRIDA 224 Query 233 SINGLGERAGNTPLEALVTTI 253 + GLG AGNTP+E L+ Sbjct 225 AAAGLGAGAGNTPMEVLIAVC 245 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Comamonas testosteroni] Sequence ID: Q9RHN1.1 Length: 345 Range 1: 165 to 245 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:28/81(35%), Positives:47/81(58%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +++ D+ G L P++ + + ++ P+ FHGH++ + VANS+ A+ AG + A Sbjct 165 VYVTDSAGYLLPDQVKERIAAVRAALKPETELGFHGHHNLAMGVANSIAAVEAGANRIDA 224 Query 233 SINGLGERAGNTPLEALVTTI 253 + GLG AGNTP+E LV Sbjct 225 AAAGLGAGAGNTPMEVLVAVC 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas fluorescens Pf0-1] Sequence ID: Q3K7C3.1 Length: 559 Range 1: 203 to 363 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:40/163(25%), Positives:68/163(41%), Gaps:13/163(7%) Query 167 SKEHIERIFLPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAI 223 + EH + LP T+ +P ++ I + + H HND VA + + Sbjct 203 TPEHKIILNLPATVECATPNVYADQIEWFHRNINRRDSVIISLHTHNDRGTGVAATELGL 262 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKR 282 AG + + G GER GN L + ++ + N + ++ I ++VE + + Sbjct 263 MAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGINPDLDFSD--IDGVRKVVEECNQIQ 320 Query 283 ISANRPIVGEDVFTQTAGVHADGDKKG-------NLYANPILP 318 + P VG+ V T +G H D +KG L+ P LP Sbjct 321 VHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQKPDTLWEVPYLP 363 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Nocardioides sp. JS614] Sequence ID: A1SH77.1 Length: 339 Range 1: 163 to 241 Score:43.9 bits(102), Expect:0.002, Method:Compositional matrix adjust., Identities:28/83(34%), Positives:40/83(48%), Gaps:9/83(10%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKYPDI-----HFEFHGHNDYDLSVANSLQAIRAGVK 228 +++ D+ G L T V + Y D+ H H + LSVANS+ A+ G Sbjct 163 VYVTDSGGRL----TMNDVRDRVAAYRDVLDPATEIGIHAHENLSLSVANSVVAVETGAV 218 Query 229 GLHASINGLGERAGNTPLEALVT 251 + AS+ G G AGN P+EA V Sbjct 219 RVDASLAGHGAGAGNCPIEAFVA 241 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Cupriavidus taiwanensis LMG 19424] Sequence ID: B2AIJ5.1 Length: 341 Range 1: 162 to 260 Score:43.9 bits(102), Expect:0.002, Method:Compositional matrix adjust., Identities:31/100(31%), Positives:56/100(56%), Gaps:2/100(2%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +++ D+ G + P + + + ++ Q P+ FHGH++ + VANSL AI G + A Sbjct 162 LYITDSAGHMLPHDVTEKLTAVRQALRPETELGFHGHHNLAMGVANSLAAITCGATRIDA 221 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 + GLG AGNTP+E LV + ++ +T ++ I + + Sbjct 222 AAAGLGAGAGNTPMEVLV-AVCERMGIETGVDVFRIADVA 260 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Clavibacter sepedonicus] Sequence ID: B0RCQ8.1 Length: 588 Range 1: 45 to 354 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:70/323(22%), Positives:127/323(39%), Gaps:39/323(12%) Query 13 VTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAAT- 71 V LRDG Q + + E+ I LL ++ +E+ S+ + + V+ ++E A Sbjct 45 VDLRDGNQAL-IDPMSPERKRIMFNLLVRMGYKEIEVGFPSASQTDFDFVRSLIEEGAIP 103 Query 72 -----EQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + LT+ E L +T + I+ + +++L S+ L++++ F TD Sbjct 104 DDVTIQVLTQAREHLI----ARTYESIRGAKQAIVHLYNSTSV--LQREV-----VFRTD 152 Query 127 VSFVIEYAIKSGLKINVYLEDWSNG---FRNSPDYVKSLVEHLSKEHIERIF-------- 175 +I+ A++ Y E + SP+ + E R+ Sbjct 153 RQGIIDIALEGARLCKRYEETIPETDVYYEYSPESYTGTELEFAAEICNRVVEVFDPTPE 212 Query 176 ------LPDTLGVLSPEETFQGVDSLIQ---KYPDIHFEFHGHNDYDLSVANSLQAIRAG 226 LP T+ + +P ++ + + + +I H HND +VA + AG Sbjct 213 RKVILNLPATVEMATPNVYADSIEWMCRHLDRRDEILVSLHPHNDRGTAVAAAELGYLAG 272 Query 227 VKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISAN 286 + + G GER GN L AL + + I+ + R E + + Sbjct 273 ADRIEGCLFGNGERTGNVDLVALGINLFTQ-GIDPQIDFSDLDGIKRTAEHCNQLAVPER 331 Query 287 RPIVGEDVFTQTAGVHADGDKKG 309 P G+ V+T +G H D KKG Sbjct 332 SPWAGDLVYTAFSGSHQDAIKKG 354 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Mesorhizobium japonicum MAFF 303099] Sequence ID: Q98HN3.1 Length: 558 Range 1: 241 to 361 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:33/125(26%), Positives:54/125(43%), Gaps:16/125(12%) Query 206 FHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINE 265 H HND +A + + AG + ++ G GER GN + L ++ + Sbjct 241 LHPHNDRGTGIATTELGLMAGADRVEGTLFGNGERTGNVDIVTLALNMYTQGVDPG---- 296 Query 266 IAITEASRLVEVFSGK---RISANRPIVGEDVFTQTAGVHADGDKKG---------NLYA 313 I ++ +R+ +V+ +I P VGE V+T +G H D KG +L+ Sbjct 297 IDCSDINRMKDVYEYSNQLKIPERHPYVGELVYTAFSGSHQDAINKGMKALKKANTSLWE 356 Query 314 NPILP 318 P LP Sbjct 357 VPYLP 361 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas putida W619] Sequence ID: B1JDI2.1 Length: 557 Range 1: 203 to 363 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:40/163(25%), Positives:68/163(41%), Gaps:13/163(7%) Query 167 SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAI 223 + EH + LP T+ V +P + + I + + H HND +A + + Sbjct 203 TPEHKVILNLPATVEVATPNIYADQIEWFCRNISRRDSVIISLHCHNDRGTGIAATELGL 262 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKR 282 AG + G GER GN L L ++ + + + + ++ I ++VE + Sbjct 263 MAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPQLDFSD--IDGVRKVVEECNQLP 320 Query 283 ISANRPIVGEDVFTQTAGVHADGDKK-------GNLYANPILP 318 + P VG+ V T +G H D +K G L+ P LP Sbjct 321 VHPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQDGELWEVPYLP 363 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas syringae pv. syringae B728a] Sequence ID: Q4ZX14.1 Length: 556 Range 1: 212 to 363 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:39/154(25%), Positives:64/154(41%), Gaps:13/154(8%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V +P + + I + + H HND VA + + AG + Sbjct 212 LPATVEVATPNIYADQIEWFGRNITRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEG 271 Query 233 SINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 + G GER GN L + ++ + N + ++ I ++VE + + P VG Sbjct 272 CLFGNGERTGNVDLVTVALNLYTQGINPGLDFSD--IDGVRKVVEECNQIPVHPRHPYVG 329 Query 292 EDVFTQTAGVHADG-------DKKGNLYANPILP 318 + V T +G H D K+G L+ P LP Sbjct 330 DLVHTAFSGSHQDAIRKGFTQQKEGELWEVPYLP 363 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Parafrankia sp. EAN1pec] Sequence ID: A8L551.1 Length: 565 Range 1: 246 to 370 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:35/126(28%), Positives:50/126(39%), Gaps:10/126(7%) Query 202 IHFEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKT 261 + H HND +VA + + AG + + G GER GN L L + + Sbjct 246 VVLSLHPHNDRGCAVAAAELGVMAGADRVEGCLFGNGERTGNVCLVTLGMNLFSQGIDPM 305 Query 262 NINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG---------NLY 312 I+ I R VE + + P G+ V+T +G H D KKG L+ Sbjct 306 -IDLSDIDGVRRTVEYCNQLPVHPRHPYGGDLVYTAFSGSHQDAIKKGFEAMERTGQTLW 364 Query 313 ANPILP 318 P LP Sbjct 365 EVPYLP 370 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas entomophila L48] Sequence ID: Q1I5K2.1 Length: 557 Range 1: 40 to 363 Score:44.3 bits(103), Expect:0.002, Method:Compositional matrix adjust., Identities:69/332(21%), Positives:132/332(39%), Gaps:36/332(10%) Query 15 LRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAATEQL 74 LRDG Q+ + +KL K L+Q + V +E + S+ + + V+ ++E Sbjct 40 LRDGNQSLIEPMDSEKKLRFWKTLVQ-VGVKEIEASFPSASQTDFDFVRTLIEDGHIPDD 98 Query 75 TERIEILGFVDGN---KTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTDVSFVI 131 T I++L + +T + ++ + +++L + + + K+ D++ Sbjct 99 TT-IQVLTQAREDLIARTFESLRGAKKAIVHLY-NATCPSFRRIVFNQDKQGVKDIAV-- 154 Query 132 EYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF--------------LP 177 A K +K D F+ SP+ + +KE + + LP Sbjct 155 -NAAKLFVKYAAQQPDTHWTFQYSPETFSATELEFAKEVCDAVIEVWNPTPEHKIILNLP 213 Query 178 DTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHASI 234 T+ V +P ++ I + + H HND +A + + AG + Sbjct 214 ATVEVATPNVYADQIEWFCRNINRRDSVIISLHTHNDRGTGIAATELGLMAGADRAEGCL 273 Query 235 NGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVGED 293 G GER GN L L ++ + + + + ++ I ++VE + + P VG+ Sbjct 274 FGNGERTGNVDLVTLALNLYTQGIDPQLDFSD--IDGVRKVVEECNQLPVHPRHPYVGDL 331 Query 294 VFTQTAGVHADGDKK-------GNLYANPILP 318 V T +G H D +K G L+ P LP Sbjct 332 VHTAFSGSHQDAIRKGFAKQQEGELWEVPYLP 363 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Burkholderia cenocepacia J2315] Sequence ID: B4EFI7.1 Length: 347 Range 1: 1 to 244 Score:43.9 bits(102), Expect:0.002, Method:Compositional matrix adjust., Identities:65/265(25%), Positives:109/265(41%), Gaps:34/265(12%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M E +L I DVTLRDG +S IA L VD +E+A +G Sbjct 1 MNSAEKKLYISDVTLRDGSHAIRHQYSVDHVRAIAA-ALDDAGVDSIEVAHGDGLQGSSF 59 Query 61 T----VQKIMEW-AATEQLTERIEILGF-VDGNKTVDWIK---DSGAKVLNLLTKGSLHH 111 +EW AA Q ++ +I + G T ++ D+GA+V+ + T + Sbjct 60 NYGFGAHTDVEWIAAAAQSVKKAKIATLLIPGIGTTHDLRHAFDAGARVVRVATHCTEAD 119 Query 112 LEKQLGKTPKEFFTD-VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEH 170 + +Q +E D V F++ + +P + + + Sbjct 120 VSRQHLDFARELGMDAVGFLMMSHM------------------TTPQKLAEQAKMMETFG 161 Query 171 IERIFLPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGV 227 +++ D+ G L E F+ + ++++ D H H++ L VANSL A+ G Sbjct 162 ATCVYVVDSGGALGMNEVRDRFRALKAVLKS--DTQTGMHAHHNLSLGVANSLVAVEEGC 219 Query 228 KGLHASINGLGERAGNTPLEALVTT 252 + AS+ G+G AGN PLE + Sbjct 220 DRIDASLAGMGAGAGNAPLEVFIAA 244 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Cupriavidus necator H16] Sequence ID: Q0K3N2.1 Length: 341 Range 1: 162 to 242 Score:43.5 bits(101), Expect:0.003, Method:Compositional matrix adjust., Identities:29/81(36%), Positives:46/81(56%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 +++ D+ G + P + + + ++ Q P+ FHGH++ + VANSL AI G + A Sbjct 162 LYITDSAGHMLPHDVTEKLGAVRQALRPETELGFHGHHNLAMGVANSLAAIACGASRIDA 221 Query 233 SINGLGERAGNTPLEALVTTI 253 + GLG AGNTP+E LV Sbjct 222 AAAGLGAGAGNTPMEVLVAVC 242 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas [fluorescens] SBW25] Sequence ID: C3K1K7.1 Length: 559 Range 1: 203 to 363 Score:43.9 bits(102), Expect:0.003, Method:Compositional matrix adjust., Identities:39/163(24%), Positives:69/163(42%), Gaps:13/163(7%) Query 167 SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAI 223 + EH + LP T+ +P + + I + + H HND VA + + Sbjct 203 TPEHKMILNLPATVECATPNIYADQIEWFGRHINRRDSVIISLHTHNDRGTGVAATELGL 262 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKR 282 AG + + G GER GN L + ++ + + + + ++ I ++VE + + Sbjct 263 MAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGLDPQLDFSD--IDGVRKVVEECNQIQ 320 Query 283 ISANRPIVGEDVFTQTAGVHADGDKKG-------NLYANPILP 318 + P VG+ V T +G H D +KG L+ P LP Sbjct 321 VHPRHPYVGDLVHTAFSGSHQDAIRKGFTQQKDDALWEVPYLP 363 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Saccharomyces cerevisiae S288C] Sequence ID: P06208.1 Length: 619 Range 1: 241 to 376 Score:43.9 bits(102), Expect:0.003, Method:Compositional matrix adjust., Identities:37/137(27%), Positives:59/137(43%), Gaps:4/137(2%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V SP + + + I + + H HND VA + + AG + Sbjct 241 LPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEG 300 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L + ++ + S N++ +T +VE + +S P G+ Sbjct 301 CLFGNGERTGNVDLVTVAMNMYTQGVSP-NLDFSDLTSVLDVVERCNKIPVSQRAPYGGD 359 Query 293 DVFTQTAGVHADGDKKG 309 V +G H D KKG Sbjct 360 LVVCAFSGSHQDAIKKG 376 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Ectopseudomonas mendocina ymp] Sequence ID: A4XY24.1 Length: 556 Range 1: 27 to 347 Score:43.9 bits(102), Expect:0.003, Method:Compositional matrix adjust., Identities:71/331(21%), Positives:128/331(38%), Gaps:34/331(10%) Query 3 KVETRLEI-LDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELET 61 KV R I L LRDG Q+ +K+ K L+ + + +E+ S+ + + Sbjct 27 KVIDRAPIWLSTDLRDGNQSLIEPMDAEKKMRFFKCLV-AVGLKEIEVGFPSASQTDFDF 85 Query 62 VQKIMEWA-ATEQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTP 120 V++++E + +T I++L + D + + + L + +H+ Sbjct 86 VRELIEGGHIPDDVT--IQVL-----TQARDDLIERTFESLKGAKRAIVHYYNACAPSFR 138 Query 121 KEFFT-DVSFVIEYAIKSGLKIN---VYLEDWSNGFRNSPDYVKSLVEHLSKEHIERIF- 175 K F D + V A+ +G I D GF SP+ S + E + Sbjct 139 KIVFNQDKAGVKAIAVAAGKTIKRLAAAQPDTQWGFEYSPEVFSSTETDFAVEVCNAVIE 198 Query 176 -------------LPDTLGVLSPEETFQGVDSL---IQKYPDIHFEFHGHNDYDLSVANS 219 LP T+ +P ++ + + + H HND VA S Sbjct 199 VFQPTPANKLILNLPATVECATPNNYADQIEWFGRHVDRRDSVLISVHTHNDRGTGVAAS 258 Query 220 LQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVF 278 A+ AG + + G GER GN L L ++ + + + + ++ I ++VE Sbjct 259 ELAVMAGADRVEGCLFGNGERTGNVCLVTLALNLYTQGVDPQLDFSD--IDAVRKVVEDC 316 Query 279 SGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 + + P G+ V T +G H D +KG Sbjct 317 NQIPVHPRHPYAGDLVHTAFSGSHQDAIRKG 347 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Brucella melitensis bv. 1 str. 16M] Sequence ID: Q8YIJ3.2 Length: 555 Range 1: 241 to 343 Score:43.9 bits(102), Expect:0.003, Method:Compositional matrix adjust., Identities:30/107(28%), Positives:48/107(44%), Gaps:7/107(6%) Query 206 FHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINE 265 H HND +A + + AG ++ G GER GN + L ++ + Sbjct 241 LHPHNDRGTGIAATELGLMAGADRGEGTLFGNGERTGNVDVVTLALNMYTQGIDPG---- 296 Query 266 IAITEASRLVEVFSGK---RISANRPIVGEDVFTQTAGVHADGDKKG 309 + T+ +R+ EV+ +I+ P VGE V+T +G H D KG Sbjct 297 LDCTDINRMKEVYEYSNQLKIAERHPYVGELVYTAFSGSHQDAINKG 343 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Burkholderia lata] Sequence ID: Q390P6.1 Length: 348 Range 1: 145 to 245 Score:43.5 bits(101), Expect:0.003, Method:Compositional matrix adjust., Identities:33/103(32%), Positives:50/103(48%), Gaps:5/103(4%) Query 154 NSPDYVKSLVEHLSKEHIERIFLPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHN 210 NSP+ + + + I++ D+ G + P++ V +Q P FHGH+ Sbjct 145 NSPEGLVKQAKLMESYGANCIYITDSAGYMLPDDVKARLGAVRDALQ--PQTELGFHGHH 202 Query 211 DYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTI 253 + + VANS+ AI AG + + GLG AGNTPLE V Sbjct 203 NLAMGVANSIAAIEAGANRIDGAAAGLGAGAGNTPLEVFVAVC 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Mycobacterium ulcerans Agy99] Sequence ID: A0PVE6.1 Length: 566 Range 1: 211 to 346 Score:43.5 bits(101), Expect:0.003, Method:Compositional matrix adjust., Identities:37/141(26%), Positives:58/141(41%), Gaps:12/141(8%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P ++ + + + + H HND +VA + AG + Sbjct 211 LPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEG 270 Query 233 SINGLGERAGNTPLEALVTTIH----DKSNSKTNINEIAITEASRLVEVFSGKRISANRP 288 + G GER GN L L + D +NI+EI R VE + + P Sbjct 271 CLFGNGERTGNVCLATLGLNLFSRGVDPQIDFSNIDEI-----RRTVEYCNQLPVPERHP 325 Query 289 IVGEDVFTQTAGVHADGDKKG 309 G+ V+T +G H D KG Sbjct 326 YGGDLVYTAFSGSHQDAINKG 346 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Mycolicibacterium smegmatis MC2 155] Sequence ID: A0QZU2.1 Length: 346 Range 1: 4 to 241 Score:43.1 bits(100), Expect:0.004, Method:Compositional matrix adjust., Identities:66/261(25%), Positives:114/261(43%), Gaps:38/261(14%) Query 6 TRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGEL------ 59 TRL I DVTLRDG G + + IA L + VD +E+ G Sbjct 4 TRLFITDVTLRDGMHAIGHRYDRGQVREIAA-ALDEAGVDAIEVGHGDGLNGSSLAYGFS 62 Query 60 --ETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSLHHLEK 114 + I E A+ + + +L + G T++ +K DSG +++ + T H E Sbjct 63 RHSDLSYIHEAASVTRRAKLACVL--LPGIGTIEDLKRARDSGIELVRIAT----HCTE- 115 Query 115 QLGKTPKEFFTDVSFV-IEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKEHIER 173 DVS I A++ G ++ +L S +P+ + + + Sbjct 116 ----------ADVSAQHISAAVELGFHVSGFLMMSSA---TTPENIGVQAAKMESYGAQC 162 Query 174 IFLPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 +++ D+ G L+P T FQ +++ + H H + LSVAN++ A+ G + + Sbjct 163 VYIADSAGNLTPAGTTARFQALEAALDGAT--QRGIHAHENLSLSVANTVVAVENGARRV 220 Query 231 HASINGLGERAGNTPLEALVT 251 A++ G+G AGN P+EA + Sbjct 221 DAALAGMGAGAGNCPIEAFIA 241 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Clavibacter michiganensis subsp. michiganensis NCPPB 382] Sequence ID: A5CRB9.1 Length: 588 Range 1: 45 to 354 Score:43.1 bits(100), Expect:0.005, Method:Compositional matrix adjust., Identities:68/323(21%), Positives:133/323(41%), Gaps:39/323(12%) Query 13 VTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELETVQKIMEWAAT- 71 V LRDG Q + + E+ I LL ++ +E+ S+ + + V+ ++E A Sbjct 45 VDLRDGNQAL-IDPMSPERKRIMFDLLVRMGYKEIEVGFPSASQTDFDFVRSLIEEGAIP 103 Query 72 -----EQLTERIEILGFVDGNKTVDWIKDSGAKVLNLLTKGSLHHLEKQLGKTPKEFFTD 126 + LT+ E L +T + ++ + +++L S+ L++++ F TD Sbjct 104 DDVTIQVLTQAREHLI----ARTYESLRGAKQAIVHLYNSTSV--LQREV-----VFRTD 152 Query 127 VSFVIEYAIKSGL----------KINVYLEDWSNGFRN-----SPDYVKSLVEHLSKEHI 171 +I+ A++ +++VY E + + + +VE L Sbjct 153 KQGIIDIALEGARLCKRYEETIPEVDVYYEYSPESYTGTELEFAAEICNRVVEVLEPTPE 212 Query 172 ERIFL--PDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAG 226 ++ L P T+ + +P ++ + + + + ++ H HND +VA + AG Sbjct 213 RKVILNLPATVEMATPNVYADSIEWMCRHLDRRDEVIVSLHPHNDRGTAVAAAELGYLAG 272 Query 227 VKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISAN 286 + + G GER GN L AL + + I+ + R E + + Sbjct 273 ADRIEGCLFGNGERTGNVDLVALGINLFTQ-GIDPQIDFSDLDGIKRTAEHCNQLAVPER 331 Query 287 RPIVGEDVFTQTAGVHADGDKKG 309 P G+ V+T +G H D KKG Sbjct 332 SPWAGDLVYTAFSGSHQDAIKKG 354 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 4; Short=HOA 4; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 4; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 4 [Dechloromonas aromatica RCB] Sequence ID: Q479H0.1 Length: 343 Range 1: 165 to 245 Score:42.7 bits(99), Expect:0.005, Method:Compositional matrix adjust., Identities:31/83(37%), Positives:46/83(55%), Gaps:5/83(6%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I++ D+ G L PE E V + ++ P+ FHGH++ + VANS+ AI G + Sbjct 165 IYVTDSAGHLLPEGVKERLSAVRAALK--PETELGFHGHHNLAMGVANSIAAIEVGANRI 222 Query 231 HASINGLGERAGNTPLEALVTTI 253 A+ GLG AGNTP+E L+ Sbjct 223 DAAAAGLGAGAGNTPMEVLIAVC 245 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Dechloromonas aromatica RCB] Sequence ID: Q47GC6.1 Length: 341 Range 1: 165 to 245 Score:42.7 bits(99), Expect:0.005, Method:Compositional matrix adjust., Identities:31/83(37%), Positives:46/83(55%), Gaps:5/83(6%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I++ D+ G L PE E V + ++ P+ FHGH++ + VANS+ AI G + Sbjct 165 IYVTDSAGHLLPEGVKERLSAVRAALK--PETELGFHGHHNLAMGVANSIAAIEVGANRI 222 Query 231 HASINGLGERAGNTPLEALVTTI 253 A+ GLG AGNTP+E L+ Sbjct 223 DAAAAGLGAGAGNTPMEVLIAVC 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Arthrobacter sp. FB24] Sequence ID: A0JX36.1 Length: 579 Range 1: 217 to 354 Score:43.1 bits(100), Expect:0.005, Method:Compositional matrix adjust., Identities:38/139(27%), Positives:58/139(41%), Gaps:4/139(2%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I LP T+ + +P ++ + + + I H HND VA + AG + Sbjct 217 INLPATVEMATPNVYADSIEWMSRHLHPREGIILSLHPHNDRGTGVAAAELGYLAGADRI 276 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 + G GER GN L L + + I+ I + R VE + ++ P Sbjct 277 EGCLFGNGERTGNVDLVTLGLNMFVQGIDPM-IDFSDIDDVRRTVEYCNQLPVAERSPYG 335 Query 291 GEDVFTQTAGVHADGDKKG 309 G+ VFT +G H D KKG Sbjct 336 GDLVFTAFSGSHQDAIKKG 354 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudarthrobacter chlorophenolicus A6] Sequence ID: B8H8Q9.1 Length: 579 Range 1: 217 to 354 Score:42.7 bits(99), Expect:0.006, Method:Compositional matrix adjust., Identities:38/139(27%), Positives:57/139(41%), Gaps:4/139(2%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I LP T+ + +P ++ + + + I H HND VA + AG + Sbjct 217 INLPATVEMATPNVYADSIEWMSRHLHPREGIILSLHPHNDRGTGVAAAELGYMAGADRI 276 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 + G GER GN L L + + I+ I + R VE + + P Sbjct 277 EGCLFGNGERTGNVDLVTLGLNLFVQGIDPM-IDFSDIDDVRRTVEYCNQLPVPERSPYG 335 Query 291 GEDVFTQTAGVHADGDKKG 309 G+ VFT +G H D KKG Sbjct 336 GDLVFTAFSGSHQDAIKKG 354 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas aeruginosa PAO1] Sequence ID: Q9HXK5.2 Length: 556 Range 1: 212 to 347 Score:42.7 bits(99), Expect:0.007, Method:Compositional matrix adjust., Identities:34/137(25%), Positives:56/137(40%), Gaps:4/137(2%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ +P + + + K + H HND VA + + AG + Sbjct 212 LPATVECATPNVYADQIEWFGRHVDKRDSVIISLHTHNDRGTGVAATELGLMAGADRVEG 271 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L ++ + ++ I ++VE + + P VG+ Sbjct 272 CLFGNGERTGNVDLVTLALNMYTQ-GLHPQLDFSDIDAVRKVVEECNQLPVHPRHPYVGD 330 Query 293 DVFTQTAGVHADGDKKG 309 V T +G H D +KG Sbjct 331 LVHTAFSGSHQDAIRKG 347 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas savastanoi pv. phaseolicola 1448A] Sequence ID: Q48LY5.1 Length: 556 Range 1: 212 to 363 Score:42.7 bits(99), Expect:0.007, Method:Compositional matrix adjust., Identities:38/154(25%), Positives:65/154(42%), Gaps:13/154(8%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ V +P + + I + + H HND VA + + AG + Sbjct 212 LPATVEVATPNIYADQIEWFGRNITRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEG 271 Query 233 SINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKRISANRPIVG 291 + G GER GN L + ++ + + + + ++ I ++VE + + P VG Sbjct 272 CLFGNGERTGNVDLVTVALNLYTQGIDPELDFSD--IDGVRKVVEECNQIPVHPRHPYVG 329 Query 292 EDVFTQTAGVHADGDKK-------GNLYANPILP 318 + V T +G H D +K G L+ P LP Sbjct 330 DLVHTAFSGSHQDAIRKGFTQQKDGELWEVPYLP 363 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas paraeruginosa PA7] Sequence ID: A6V0X2.1 Length: 556 Range 1: 203 to 347 Score:42.7 bits(99), Expect:0.007, Method:Compositional matrix adjust., Identities:35/146(24%), Positives:60/146(41%), Gaps:4/146(2%) Query 167 SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAI 223 + EH + LP T+ +P + + + + + H HND VA + + Sbjct 203 TPEHKIILNLPATVECATPNVYADQIEWFGRHVNRRDSVIISLHTHNDRGTGVAATELGL 262 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRI 283 AG + + G GER GN L L ++ + ++ I ++VE + + Sbjct 263 MAGADRVEGCLFGNGERTGNVDLVTLALNMYTQ-GLHPQLDFSDIDAVRKVVEECNQLPV 321 Query 284 SANRPIVGEDVFTQTAGVHADGDKKG 309 P VG+ V T +G H D +KG Sbjct 322 HPRHPYVGDLVHTAFSGSHQDAIRKG 347 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Leifsonia xyli subsp. xyli str. CTCB07] Sequence ID: Q6AED3.1 Length: 590 Range 1: 217 to 354 Score:42.4 bits(98), Expect:0.009, Method:Compositional matrix adjust., Identities:37/139(27%), Positives:58/139(41%), Gaps:4/139(2%) Query 174 IFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I LP T+ + +P ++ + + + ++ H HND +VA + AG + Sbjct 217 INLPATVEMATPNVYADSIEWMSRHLNHRENVILSLHPHNDRGTAVAAAELGYLAGADRI 276 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIV 290 + G GER GN L L + + I+ I R VE + + P Sbjct 277 EGCLFGNGERTGNVDLVTLGVNLFTQ-GIDPQIDFSDIDHIKRTVEHCNQLPVGERSPWG 335 Query 291 GEDVFTQTAGVHADGDKKG 309 G+ VFT +G H D KKG Sbjct 336 GDLVFTAFSGSHQDAIKKG 354 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 3; Short=HOA 3; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 3; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 3 [Paraburkholderia xenovorans LB400] Sequence ID: Q13QH6.1 Length: 338 Range 1: 1 to 241 Score:42.0 bits(97), Expect:0.009, Method:Compositional matrix adjust., Identities:62/266(23%), Positives:114/266(42%), Gaps:42/266(15%) Query 4 VETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKG------ 57 ++ +L I DVTLRDG +S IA+ L VD +E+A +G Sbjct 1 MDRKLYISDVTLRDGSHAIRHQYSIDNVQQIAR-ALDSAKVDSIEVAHGDGLQGSSFNYG 59 Query 58 -----ELETVQKIMEWAATEQLTERIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSL 109 +LE ++ + + Q+ + + G T+ +K +GA+++ + T Sbjct 60 FGAHSDLEWIEAVADVVGHAQIATLL-----LPGIGTIHDLKAAYQAGARIVRVAT---- 110 Query 110 HHLEKQLGKTPKEFFTDVSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKE 169 H E + K IEYA + G+ +L +P+ + + + Sbjct 111 HCTEADISKQH----------IEYARELGMDTVGFL---MMSHMTTPENLAVEAKKMESY 157 Query 170 HIERIFLPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAG 226 I++ D+ G ++ + F+ + ++++ P+ H H++ L VANSL A+ G Sbjct 158 GATCIYVVDSGGAMNMNDVRARFRALKAVLK--PETKTGMHAHHNLSLGVANSLVAVEEG 215 Query 227 VKGLHASINGLGERAGNTPLEALVTT 252 + AS+ G+G AGN PLE + Sbjct 216 CDRIDASLAGMGAGAGNAPLEVFIAA 241 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Sinorhizobium meliloti 1021] Sequence ID: Q9X7L2.3 Length: 558 Range 1: 206 to 343 Score:42.0 bits(97), Expect:0.011, Method:Compositional matrix adjust., Identities:36/143(25%), Positives:62/143(43%), Gaps:12/143(8%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY---PDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I LP T+ + +P ++ + + ++ H HND +A + + AG + Sbjct 206 INLPSTVEMATPNIYADQIEWMCRNLDNRENLIVSLHPHNDRGTGIAATELGLMAGADRV 265 Query 231 HASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKR---ISAN 286 ++ G GER GN + L + + + K + ++I R+ EV+ I Sbjct 266 EGTLFGNGERTGNVDVVTLALNMFTQGVDPKLDCSDI-----ERIKEVYEYSNQMVIPER 320 Query 287 RPIVGEDVFTQTAGVHADGDKKG 309 P VGE V+T +G H D KG Sbjct 321 HPYVGELVYTAFSGSHQDAINKG 343 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Leptothrix cholodnii SP-6] Sequence ID: B1Y2E5.1 Length: 345 Range 1: 165 to 271 Score:41.6 bits(96), Expect:0.011, Method:Compositional matrix adjust., Identities:32/110(29%), Positives:60/110(54%), Gaps:8/110(7%) Query 174 IFLPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I++ D+ G + P + + V + ++ P+ FHGH++ + VANS+ A+ AG + Sbjct 165 IYVTDSAGYMLPGDVKLRLEAVRAALR--PETELGFHGHHNLAMGVANSVAAVEAGANRI 222 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS--RLVEVF 278 A+ GLG AGNTP+E + + D+ +T ++ I + + R+V + Sbjct 223 DAAAAGLGAGAGNTPMEVFI-AVCDRMGIETGVDVFKIQDVAEDRVVPIM 271 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas putida KT2440] Sequence ID: Q88P28.1 Length: 557 Range 1: 203 to 363 Score:42.0 bits(97), Expect:0.011, Method:Compositional matrix adjust., Identities:39/162(24%), Positives:65/162(40%), Gaps:11/162(6%) Query 167 SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAI 223 + EH + LP T+ V +P + + + + + H HND +A + + Sbjct 203 TPEHKIILNLPATVEVSTPNIYADQIEWFCRNVSRRDSVIISLHCHNDRGTGIAATELGL 262 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRI 283 AG + G GER GN L L ++ + ++ I ++VE + + Sbjct 263 MAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPL-LDFSDIDGVRKVVEECNQLPV 321 Query 284 SANRPIVGEDVFTQTAGVHADGDKK-------GNLYANPILP 318 P VG+ V T +G H D +K G L+ P LP Sbjct 322 HPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQDGELWEVPYLP 363 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas putida F1] Sequence ID: A5VZB6.1 Length: 557 Range 1: 203 to 363 Score:42.0 bits(97), Expect:0.012, Method:Compositional matrix adjust., Identities:39/162(24%), Positives:65/162(40%), Gaps:11/162(6%) Query 167 SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAI 223 + EH + LP T+ V +P + + + + + H HND +A + + Sbjct 203 TPEHKIILNLPATVEVSTPNIYADQIEWFCRNVSRRDSVIISLHCHNDRGTGIAATELGL 262 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRI 283 AG + G GER GN L L ++ + ++ I ++VE + + Sbjct 263 MAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPL-LDFSDIDGVRKVVEECNQLPV 321 Query 284 SANRPIVGEDVFTQTAGVHADGDKK-------GNLYANPILP 318 P VG+ V T +G H D +K G L+ P LP Sbjct 322 HPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQDGELWEVPYLP 363 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Dechloromonas aromatica RCB] Sequence ID: Q47HL8.1 Length: 343 Range 1: 165 to 245 Score:41.6 bits(96), Expect:0.013, Method:Compositional matrix adjust., Identities:29/81(36%), Positives:46/81(56%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I++ D+ G L PE + + ++ + P+ FHGH++ + VANS+ AI G + A Sbjct 165 IYVTDSAGHLLPEGVKERLGAVRKALKPETELGFHGHHNLAMGVANSIAAIEVGANRIDA 224 Query 233 SINGLGERAGNTPLEALVTTI 253 + GLG AGNTP+E L+ Sbjct 225 AAAGLGAGAGNTPMEVLIAVC 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Hydrogenovibrio crunogenus XCL-2] Sequence ID: Q31EF5.1 Length: 539 Range 1: 207 to 366 Score:41.6 bits(96), Expect:0.013, Method:Compositional matrix adjust., Identities:40/164(24%), Positives:64/164(39%), Gaps:20/164(12%) Query 176 LPDTLGVLSPEETFQGVDSLIQKYPDIH---FEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ SP V+ I + H HND +VA + ++ AG + Sbjct 207 LPATVESTSPNRFADQVEYFITHLKNRESAIISIHTHNDRGCAVAAAELSLLAGADRVEG 266 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVF---SGKRISANRPI 289 ++ G GER GN + L ++ + E+ +++ V V + P Sbjct 267 TLLGNGERTGNMDIVTLAMNLYSEGIDP----ELNLSDPDSWVPVIEEVTKIDTHVRHPW 322 Query 290 VGEDVFTQTAGVHADG----------DKKGNLYANPILPERFGR 323 VGE V+T +G H D D+ N+ PI P+ R Sbjct 323 VGEAVYTAYSGSHQDAIRKCLMRQKDDEPWNVAYLPIDPKDLNR 366 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Mycobacterium tuberculosis CDC1551] Sequence ID: P9WQB2.1 Length: 644 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Mycobacterium tuberculosis H37Rv] Sequence ID: P9WQB3.1 Length: 644 Range 1: 251 to 386 Score:42.0 bits(97), Expect:0.014, Method:Compositional matrix adjust., Identities:35/137(26%), Positives:56/137(40%), Gaps:4/137(2%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P ++ + + + + H HND +VA + AG + Sbjct 251 LPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEG 310 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L + + I+ I E R VE + + P G+ Sbjct 311 CLFGNGERTGNVCLVTLGLNLFSR-GVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGD 369 Query 293 DVFTQTAGVHADGDKKG 309 V+T +G H D KG Sbjct 370 LVYTAFSGSHQDAINKG 386 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 4; Short=HOA 4; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 4; AltName: Full=4-hydroxy-2-oxohexanoate aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 4 [Paraburkholderia xenovorans LB400] Sequence ID: P51015.2 Length: 346 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 2; Short=HOA 2; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 2; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 2 [Metapseudomonas furukawaii] Sequence ID: Q52040.1 Length: 346 Range 1: 165 to 245 Score:41.2 bits(95), Expect:0.015, Method:Compositional matrix adjust., Identities:28/83(34%), Positives:46/83(55%), Gaps:5/83(6%) Query 174 IFLPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I++ D+ G + P++ V + ++ P+ FHGH++ + VANS+ AI AG + Sbjct 165 IYVTDSAGYMLPDDVKARLSAVRAALK--PETELGFHGHHNLAMGVANSIAAIEAGATRI 222 Query 231 HASINGLGERAGNTPLEALVTTI 253 A+ GLG AGNTP+E + Sbjct 223 DAAAAGLGAGAGNTPMEVFIAVC 245 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Methylibium petroleiphilum PM1] Sequence ID: A2SI33.1 Length: 349 Range 1: 166 to 264 Score:41.2 bits(95), Expect:0.016, Method:Compositional matrix adjust., Identities:30/102(29%), Positives:55/102(53%), Gaps:6/102(5%) Query 174 IFLPDTLGVLSPEET---FQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGL 230 I++ D+ G + P++ + V ++ P+ FHGH++ + VANS+ A+ AG + Sbjct 166 IYVTDSAGYMLPDDVTVRLRAVRGALK--PETELGFHGHHNLAMGVANSIAAVDAGANRI 223 Query 231 HASINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEAS 272 A+ GLG AGNTP+E + + D+ T ++ I + + Sbjct 224 DAAAAGLGAGAGNTPMEVFI-AVCDRMGIATGVDVFRIQDVA 264 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Kineococcus radiotolerans SRS30216 = ATCC BAA-149] Sequence ID: A6WDF2.1 Length: 575 Range 1: 219 to 354 Score:41.6 bits(96), Expect:0.016, Method:Compositional matrix adjust., Identities:36/137(26%), Positives:57/137(41%), Gaps:4/137(2%) Query 176 LPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 LP T+ + +P ++ + + + + ++ H HND VA + AG + Sbjct 219 LPATVEMATPNVYADSIEWMSRHLDQRENVIISLHPHNDRGTGVAAAELGYLAGADRIEG 278 Query 233 SINGLGERAGNTPLEALVTTIHDKSNSKTNINEIAITEASRLVEVFSGKRISANRPIVGE 292 + G GER GN L L + + I+ I R VE + + P G+ Sbjct 279 CLFGNGERTGNVDLVTLGMNLFSQ-GIDPQIDFSDIDHIRRTVEHCNQLPVGERVPYGGD 337 Query 293 DVFTQTAGVHADGDKKG 309 VFT +G H D KKG Sbjct 338 LVFTAFSGSHQDAIKKG 354 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Pseudomonas putida GB-1] Sequence ID: B0KRD9.1 Length: 557 Range 1: 203 to 347 Score:41.2 bits(95), Expect:0.018, Method:Compositional matrix adjust., Identities:35/147(24%), Positives:63/147(42%), Gaps:6/147(4%) Query 167 SKEHIERIFLPDTLGVLSPE---ETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAI 223 + EH + LP T+ V +P + + + + + H HND +A + + Sbjct 203 TPEHKIILNLPATVEVSTPNIYADQIEWFCRNVSRRDSVIISLHCHNDRGTGIAATELGL 262 Query 224 RAGVKGLHASINGLGERAGNTPLEALVTTIHDKS-NSKTNINEIAITEASRLVEVFSGKR 282 AG + G GER GN L L ++ + + + + ++ I ++VE + Sbjct 263 MAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPQLDFSD--IDGVRKVVEECNQLP 320 Query 283 ISANRPIVGEDVFTQTAGVHADGDKKG 309 + P VG+ V T +G H D +KG Sbjct 321 VHPRHPYVGDLVHTAFSGSHQDAIRKG 347 >RecName: Full=4-hydroxy-2-oxovalerate aldolase 1; Short=HOA 1; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase 1; AltName: Full=4-hydroxy-2-oxopentanoate aldolase 1 [Burkholderia lata] Sequence ID: Q397Q9.1 Length: 355 Range 1: 1 to 244 Score:40.8 bits(94), Expect:0.019, Method:Compositional matrix adjust., Identities:64/263(24%), Positives:108/263(41%), Gaps:30/263(11%) Query 1 MTKVETRLEILDVTLRDGEQTRGVSFSTSEKLNIAKFLLQKLNVDRVEIASARVSKGELE 60 M +L I DVTLRDG +S + IA L + VD +E+A +G Sbjct 1 MNDARKKLYISDVTLRDGSHAIRHQYSIANVKAIAA-ALDRAGVDSIEVAHGDGIEGSSF 59 Query 61 T----VQKIMEW---AATEQLTERIEILGFVDGNKTVDWIK---DSGAKVLNLLTKGSLH 110 +EW AA +I L + G T+ ++ D+GA+V+ + T + Sbjct 60 NYGFGAHSDVEWIEAAAASVKHAKIATL-LIPGIGTIHDLRNAYDAGARVVRVATHCTEA 118 Query 111 HLEKQLGKTPKEFFTD-VSFVIEYAIKSGLKINVYLEDWSNGFRNSPDYVKSLVEHLSKE 169 + +Q + +E D V F++ + + K+ + L+E Sbjct 119 DVSRQHLEYAREIGMDPVGFLMMSHMTTPQKLAEQAK---------------LMESYGAT 163 Query 170 HIERIFLPDTLGVLSPEETFQGVDSLIQKYPDIHFEFHGHNDYDLSVANSLQAIRAGVKG 229 + + LG+ + F+ ++ P+ H H++ L VANSL A+ G Sbjct 164 CVYVVDSGGALGMNDIRDRFRAFKEALK--PETQTGMHAHHNLSLGVANSLVAVEEGCDR 221 Query 230 LHASINGLGERAGNTPLEALVTT 252 + AS+ G+G AGN PLE + Sbjct 222 IDASLAGMGAGAGNAPLEVFIAA 244 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Polaromonas naphthalenivorans CJ2] Sequence ID: A1VUV1.1 Length: 346 Range 1: 165 to 245 Score:40.8 bits(94), Expect:0.022, Method:Compositional matrix adjust., Identities:27/81(33%), Positives:45/81(55%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I++ D+ G + P++ + ++ P+ FHGH++ + VANS+ AI AG + A Sbjct 165 IYVTDSAGYMLPDDVKARLGAVRAALKPETELGFHGHHNMAMGVANSIAAIEAGANRIDA 224 Query 233 SINGLGERAGNTPLEALVTTI 253 + GLG AGNTP+E + Sbjct 225 AAAGLGAGAGNTPMEVFIAVC 245 >RecName: Full=2-isopropylmalate synthase; AltName: Full=Alpha-IPM synthase; AltName: Full=Alpha-isopropylmalate synthase [Mycobacterium tuberculosis variant bovis AF2122/97] Sequence ID: Q7TVV6.1 Length: 701 Range 1: 282 to 386 Score:41.2 bits(95), Expect:0.022, Method:Compositional matrix adjust., Identities:33/110(30%), Positives:45/110(40%), Gaps:9/110(8%) Query 204 FEFHGHNDYDLSVANSLQAIRAGVKGLHASINGLGERAGNTPLEALVTTIH----DKSNS 259 H HND +VA + AG + + G GER GN L L + D Sbjct 282 LSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQID 341 Query 260 KTNINEIAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKG 309 +NI+EI R VE + + P G+ V+T +G H D KG Sbjct 342 FSNIDEI-----RRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKG 386 >RecName: Full=4-hydroxy-2-oxovalerate aldolase; Short=HOA; AltName: Full=4-hydroxy-2-keto-pentanoic acid aldolase; AltName: Full=4-hydroxy-2-oxopentanoate aldolase [Rhodoferax ferrireducens T118] Sequence ID: Q221U7.1 Length: 342 Range 1: 165 to 245 Score:39.7 bits(91), Expect:0.047, Method:Compositional matrix adjust., Identities:26/81(32%), Positives:44/81(54%), Gaps:1/81(1%) Query 174 IFLPDTLGVLSPEETFQGVDSLIQKY-PDIHFEFHGHNDYDLSVANSLQAIRAGVKGLHA 232 I++ D+ G + P E + ++ P+ FHGH++ + VANS+ A+ +G + A Sbjct 165 IYITDSAGYMLPAEVKEKTSAVRAALRPETELGFHGHHNLAMGVANSVVAVESGATRIDA 224 Query 233 SINGLGERAGNTPLEALVTTI 253 + GLG AGNTP+E + Sbjct 225 AAAGLGAGAGNTPMEVFIAVC 245